SCLT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an adaptor protein. Studies of a related gene in rat suggest that the encoded protein functions to link clathrin to the sodium channel protein type 10 subunit alpha protein. The encoded protein has also been identified as a component of distal appendages of centrioles that is necessary for ciliogenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.83333166
2fusion of sperm to egg plasma membrane (GO:0007342)7.93557835
3axonemal dynein complex assembly (GO:0070286)7.91137087
4epithelial cilium movement (GO:0003351)7.76472927
5sperm motility (GO:0030317)7.47866846
6cell wall macromolecule catabolic process (GO:0016998)7.41382444
7cell wall macromolecule metabolic process (GO:0044036)7.41382444
8cilium movement (GO:0003341)7.18474653
9motile cilium assembly (GO:0044458)7.05911151
10multicellular organism reproduction (GO:0032504)6.90540291
11acrosome assembly (GO:0001675)6.49920476
12sperm-egg recognition (GO:0035036)6.48470113
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.38249044
14acrosome reaction (GO:0007340)6.35208957
15plasma membrane fusion (GO:0045026)6.07995053
16cell-cell recognition (GO:0009988)5.85790722
17binding of sperm to zona pellucida (GO:0007339)5.81439211
18spermatid development (GO:0007286)5.68832782
19microtubule depolymerization (GO:0007019)5.68367020
20male meiosis (GO:0007140)5.67467204
21piRNA metabolic process (GO:0034587)5.59367318
22reproduction (GO:0000003)5.58372417
23neural tube formation (GO:0001841)4.84574853
24single fertilization (GO:0007338)4.74854687
25synaptonemal complex organization (GO:0070193)4.73281771
26synaptonemal complex assembly (GO:0007130)4.63665978
27regulation of cilium movement (GO:0003352)4.57507290
28mitotic sister chromatid cohesion (GO:0007064)4.57374637
29centriole assembly (GO:0098534)4.41436621
30meiotic chromosome segregation (GO:0045132)4.35971601
31DNA methylation involved in gamete generation (GO:0043046)4.23439106
32male meiosis I (GO:0007141)4.09760923
33monoubiquitinated protein deubiquitination (GO:0035520)4.09499050
34ventricular system development (GO:0021591)4.06074045
35centriole replication (GO:0007099)4.04698864
36sperm capacitation (GO:0048240)3.99612354
37meiotic cell cycle (GO:0051321)3.93979197
38axoneme assembly (GO:0035082)3.93041832
39fertilization (GO:0009566)3.91274670
40spermatogenesis (GO:0007283)3.89886423
41spermatid nucleus differentiation (GO:0007289)3.89677011
42male gamete generation (GO:0048232)3.89300392
43chromosome organization involved in meiosis (GO:0070192)3.87342620
44microglial cell activation (GO:0001774)3.67975053
45protein K11-linked deubiquitination (GO:0035871)3.67004341
46gamete generation (GO:0007276)3.66796489
47hepatocyte apoptotic process (GO:0097284)3.64725382
48sister chromatid cohesion (GO:0007062)3.59043417
49meiotic nuclear division (GO:0007126)3.57334477
50positive regulation of mast cell activation (GO:0033005)3.56152758
51establishment of protein localization to Golgi (GO:0072600)3.55297453
52regulation of B cell receptor signaling pathway (GO:0050855)3.49586255
53protein neddylation (GO:0045116)3.47901365
54* cilium organization (GO:0044782)3.41792574
55single strand break repair (GO:0000012)3.41540341
56kinetochore organization (GO:0051383)3.41057778
57presynaptic membrane organization (GO:0097090)3.39205193
58intraciliary transport (GO:0042073)3.38067522
59replication fork processing (GO:0031297)3.37089245
60germ cell development (GO:0007281)3.36846251
61* cilium assembly (GO:0042384)3.36233473
62cellular process involved in reproduction in multicellular organism (GO:0022412)3.31211770
63histone exchange (GO:0043486)3.29697903
64regulation of DNA endoreduplication (GO:0032875)3.23378758
65meiosis I (GO:0007127)3.20567911
66protein targeting to Golgi (GO:0000042)3.19716276
67negative regulation of inclusion body assembly (GO:0090084)3.18247117
68neutrophil activation involved in immune response (GO:0002283)3.16560147
69response to X-ray (GO:0010165)3.15854436
70regulation of MHC class II biosynthetic process (GO:0045346)3.14959897
71cell recognition (GO:0008037)3.14164615
72behavioral response to nicotine (GO:0035095)3.13744792
73regulation of centriole replication (GO:0046599)3.12131826
74histone mRNA catabolic process (GO:0071044)3.11953755
75DNA double-strand break processing (GO:0000729)3.07569733
76DNA packaging (GO:0006323)3.06558819
77DNA synthesis involved in DNA repair (GO:0000731)3.03410139
78RNA destabilization (GO:0050779)3.03195132
79microtubule polymerization or depolymerization (GO:0031109)3.01112192
80nuclear pore complex assembly (GO:0051292)2.99938925
81phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.99927338
82regulation of spindle checkpoint (GO:0090231)2.99622586
83calcium ion-dependent exocytosis (GO:0017156)2.97745409
84retrograde transport, vesicle recycling within Golgi (GO:0000301)2.97596140
85prenylation (GO:0097354)2.97000945
86protein prenylation (GO:0018342)2.97000945
87histone H3-K9 methylation (GO:0051567)2.95421956
88regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.95404731
89regulation of mitotic spindle checkpoint (GO:1903504)2.95404731
90chromosome condensation (GO:0030261)2.95048583
91intra-S DNA damage checkpoint (GO:0031573)2.94270324
92kinetochore assembly (GO:0051382)2.94044246
93meiotic cell cycle process (GO:1903046)2.93934922
94indolalkylamine metabolic process (GO:0006586)2.93184530
95reciprocal DNA recombination (GO:0035825)2.90294436
96reciprocal meiotic recombination (GO:0007131)2.90294436
97activated T cell proliferation (GO:0050798)2.89358447
98neutrophil mediated immunity (GO:0002446)2.88238033
99protein localization to cilium (GO:0061512)2.87813468
100positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.86263062
101maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85218220
102dopamine transport (GO:0015872)2.84902381
103regulation of meiosis I (GO:0060631)2.84132389
104left/right axis specification (GO:0070986)2.83773571
105negative regulation of translation, ncRNA-mediated (GO:0040033)2.83272812
106regulation of translation, ncRNA-mediated (GO:0045974)2.83272812
107negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83272812
108recombinational repair (GO:0000725)2.82822169
109multicellular organismal reproductive process (GO:0048609)2.82675013
110presynaptic membrane assembly (GO:0097105)2.82662917
111double-strand break repair via homologous recombination (GO:0000724)2.82241748
112detection of molecule of bacterial origin (GO:0032490)2.81403671
113protein K63-linked deubiquitination (GO:0070536)2.80770949
114* cellular component assembly involved in morphogenesis (GO:0010927)2.79607383
115genitalia morphogenesis (GO:0035112)2.78866117
116positive regulation of mast cell activation involved in immune response (GO:0033008)2.78157899
117positive regulation of mast cell degranulation (GO:0043306)2.78157899
118regulation of mast cell activation (GO:0033003)2.76925987
119regulation of memory T cell differentiation (GO:0043380)2.76409481
120platelet dense granule organization (GO:0060155)2.75937669
121interkinetic nuclear migration (GO:0022027)2.74988815
122protein K6-linked ubiquitination (GO:0085020)2.74932990
123negative regulation of DNA-dependent DNA replication (GO:2000104)2.74757402
124pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.74498847
125microtubule severing (GO:0051013)2.72197718
126chromatin remodeling at centromere (GO:0031055)2.68982641
127fucose catabolic process (GO:0019317)2.68707074
128L-fucose metabolic process (GO:0042354)2.68707074
129L-fucose catabolic process (GO:0042355)2.68707074
130adenosine metabolic process (GO:0046085)2.68389551
131peptidyl-lysine trimethylation (GO:0018023)2.68034035
132microtubule anchoring (GO:0034453)2.66064699
133negative regulation of neurotransmitter transport (GO:0051589)2.65148666
134left/right pattern formation (GO:0060972)2.64425054
135neutrophil activation (GO:0042119)2.63619189
136protein polyglutamylation (GO:0018095)2.63551975
137rRNA catabolic process (GO:0016075)2.57325818
138organic cation transport (GO:0015695)2.56795292
139RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54839802
140CENP-A containing nucleosome assembly (GO:0034080)2.54116006
141cellular response to gamma radiation (GO:0071480)2.53097261
142attachment of spindle microtubules to kinetochore (GO:0008608)2.52494423
143resolution of meiotic recombination intermediates (GO:0000712)2.49124757
144synapsis (GO:0007129)2.48939765
145histone H3-K4 trimethylation (GO:0080182)2.48628311
146CTP metabolic process (GO:0046036)2.46604146
147CTP biosynthetic process (GO:0006241)2.46604146
148histone H3-K36 demethylation (GO:0070544)2.46406047
149DNA ligation (GO:0006266)2.45933334
150purinergic nucleotide receptor signaling pathway (GO:0035590)2.45672580
151regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.44087426
152myeloid leukocyte mediated immunity (GO:0002444)2.43247823
153photoreceptor cell maintenance (GO:0045494)2.40938645
154positive regulation of gamma-delta T cell activation (GO:0046645)2.38735439
155interferon-gamma production (GO:0032609)2.37700870
156tryptophan metabolic process (GO:0006568)2.34863877
157response to pheromone (GO:0019236)2.34645056
158cellular extravasation (GO:0045123)2.33837143
159negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.33810897
160cilium morphogenesis (GO:0060271)2.33167230
161leukocyte migration involved in inflammatory response (GO:0002523)2.29621875
162positive regulation by symbiont of host defense response (GO:0052509)2.29497420
163modulation by symbiont of host defense response (GO:0052031)2.29497420
164modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.29497420
165modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.29497420
166positive regulation by organism of defense response of other organism involved in symbiotic interact2.29497420
167modulation by symbiont of host immune response (GO:0052553)2.29497420
168centrosome organization (GO:0051297)2.28519498
169microtubule organizing center organization (GO:0031023)2.28097080
170positive regulation of toll-like receptor signaling pathway (GO:0034123)2.27946390
171regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.27935049
172natural killer cell activation involved in immune response (GO:0002323)2.27362231
173mast cell activation (GO:0045576)2.23756934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.02987915
2EZH2_22144423_ChIP-Seq_EOC_Human3.41748666
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17750452
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.16125157
5FLI1_27457419_Chip-Seq_LIVER_Mouse3.03133226
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.94860950
7E2F7_22180533_ChIP-Seq_HELA_Human2.88503768
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.82384541
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.74622731
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66360284
11GBX2_23144817_ChIP-Seq_PC3_Human2.52183506
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43436933
13FUS_26573619_Chip-Seq_HEK293_Human2.36148946
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.31293845
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.30387645
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25473202
17NFE2_27457419_Chip-Seq_LIVER_Mouse2.22404755
18* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.13461422
19TAF15_26573619_Chip-Seq_HEK293_Human2.12707648
20* NANOG_18555785_Chip-Seq_ESCs_Mouse2.06834624
21* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.98955953
22EZH2_27294783_Chip-Seq_NPCs_Mouse1.95809653
23P53_22387025_ChIP-Seq_ESCs_Mouse1.90417052
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.87675360
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85797040
26CMYC_18555785_Chip-Seq_ESCs_Mouse1.83066981
27SUZ12_18555785_Chip-Seq_ESCs_Mouse1.82082230
28E2F1_18555785_Chip-Seq_ESCs_Mouse1.81855324
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81799560
30* STAT3_18555785_Chip-Seq_ESCs_Mouse1.76076062
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75790304
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73882081
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73759939
34IRF1_19129219_ChIP-ChIP_H3396_Human1.73741151
35* OCT4_18555785_Chip-Seq_ESCs_Mouse1.73642427
36P300_18555785_Chip-Seq_ESCs_Mouse1.72347852
37EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.70425907
38TAL1_26923725_Chip-Seq_HPCs_Mouse1.68283188
39RNF2_27304074_Chip-Seq_NSC_Mouse1.62505479
40* P300_19829295_ChIP-Seq_ESCs_Human1.61421641
41NMYC_18555785_Chip-Seq_ESCs_Mouse1.60767838
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60625340
43EWS_26573619_Chip-Seq_HEK293_Human1.59672218
44SOX2_18555785_Chip-Seq_ESCs_Mouse1.58480473
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58477143
46CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.56131186
47RUNX1_27457419_Chip-Seq_LIVER_Mouse1.55329374
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55006039
49VDR_22108803_ChIP-Seq_LS180_Human1.54568655
50IGF1R_20145208_ChIP-Seq_DFB_Human1.53191097
51ZFX_18555785_Chip-Seq_ESCs_Mouse1.52819202
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52546388
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.52160040
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52021903
55BCAT_22108803_ChIP-Seq_LS180_Human1.51913152
56* KLF4_18555785_Chip-Seq_ESCs_Mouse1.50603291
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50362929
58* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.50014900
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49048407
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.48844142
61SMAD4_21799915_ChIP-Seq_A2780_Human1.48277302
62CTCF_18555785_Chip-Seq_ESCs_Mouse1.48102841
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46178432
64PU1_27457419_Chip-Seq_LIVER_Mouse1.45645318
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45088638
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43905721
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43881384
68* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43247796
69ELK1_19687146_ChIP-ChIP_HELA_Human1.42293192
70OCT4_21477851_ChIP-Seq_ESCs_Mouse1.41985515
71KDM2B_26808549_Chip-Seq_REH_Human1.41400270
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40809849
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40809849
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.40427460
75SMAD1_18555785_Chip-Seq_ESCs_Mouse1.38931314
76ER_23166858_ChIP-Seq_MCF-7_Human1.38176260
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37071790
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36293952
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35120581
80CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.31738548
81* TCF4_23295773_ChIP-Seq_U87_Human1.28037499
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.27864940
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27804080
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.27804020
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27586898
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.26967381
87ZNF274_21170338_ChIP-Seq_K562_Hela1.25550484
88* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24477329
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.23679533
90TP53_22573176_ChIP-Seq_HFKS_Human1.23160333
91STAT3_23295773_ChIP-Seq_U87_Human1.23092093
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22772204
93* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22035544
94SOX9_26525672_Chip-Seq_HEART_Mouse1.20406234
95SCL_19346495_ChIP-Seq_HPC-7_Human1.20321052
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19970378
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18429397
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18243930
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17901922
100CBP_20019798_ChIP-Seq_JUKART_Human1.17898827
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17898827
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.17158137
103SOX2_19829295_ChIP-Seq_ESCs_Human1.17090235
104NANOG_19829295_ChIP-Seq_ESCs_Human1.17090235
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16807092
106KAP1_22055183_ChIP-Seq_ESCs_Mouse1.14847671
107TCF4_22108803_ChIP-Seq_LS180_Human1.13788617
108FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13424842
109* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12427778
110HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11893778
111* RUNX2_22187159_ChIP-Seq_PCA_Human1.10303853
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09301882
113SALL4_22934838_ChIP-ChIP_CD34+_Human1.09219317
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08369534
115GATA1_22025678_ChIP-Seq_K562_Human1.07689256
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07256010
117GATA1_26923725_Chip-Seq_HPCs_Mouse1.07214265
118GATA3_26560356_Chip-Seq_TH2_Human1.06854609
119VDR_23849224_ChIP-Seq_CD4+_Human1.06348159
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05350114
121* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04059632
122STAT1_17558387_ChIP-Seq_HELA_Human1.02077957
123LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01123791
124CDX2_22108803_ChIP-Seq_LS180_Human1.00779705
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00361228
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00353682
127* SMAD4_21741376_ChIP-Seq_EPCs_Human1.00307005
128RUNX_20019798_ChIP-Seq_JUKART_Human0.99789019
129GF1_26923725_Chip-Seq_HPCs_Mouse0.98148178
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95777249
131FLI1_21867929_ChIP-Seq_TH2_Mouse0.95582511
132GF1B_26923725_Chip-Seq_HPCs_Mouse0.94560906
133RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94555189
134AR_25329375_ChIP-Seq_VCAP_Human0.94352017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.31001301
2MP0008877_abnormal_DNA_methylation4.42828591
3MP0008057_abnormal_DNA_replication3.63173365
4MP0003698_abnormal_male_reproductive3.48044364
5MP0001929_abnormal_gametogenesis3.42071187
6MP0008058_abnormal_DNA_repair3.19449671
7MP0003787_abnormal_imprinting3.17281719
8MP0003724_increased_susceptibility_to3.16840208
9MP0001188_hyperpigmentation3.04773271
10MP0006292_abnormal_olfactory_placode2.95290814
11MP0010094_abnormal_chromosome_stability2.77101868
12MP0002102_abnormal_ear_morphology2.76498533
13MP0002210_abnormal_sex_determination2.67931318
14MP0005464_abnormal_platelet_physiology2.39239096
15MP0001835_abnormal_antigen_presentation2.21427583
16MP0000569_abnormal_digit_pigmentation2.18681566
17MP0001145_abnormal_male_reproductive2.15078114
18MP0005409_darkened_coat_color2.13671447
19MP0000653_abnormal_sex_gland2.01855935
20MP0003121_genomic_imprinting1.89573511
21MP0005671_abnormal_response_to1.87338022
22MP0002161_abnormal_fertility/fecundity1.86801136
23MP0008995_early_reproductive_senescence1.86311408
24MP0003111_abnormal_nucleus_morphology1.82109662
25MP0000015_abnormal_ear_pigmentation1.80819495
26MP0003136_yellow_coat_color1.71409497
27MP0003693_abnormal_embryo_hatching1.68980848
28MP0003195_calcinosis1.57898140
29MP0001800_abnormal_humoral_immune1.55996626
30MP0004142_abnormal_muscle_tone1.53253425
31MP0002160_abnormal_reproductive_system1.48462364
32MP0004147_increased_porphyrin_level1.42938166
33MP0003077_abnormal_cell_cycle1.41739583
34MP0003890_abnormal_embryonic-extraembry1.40134510
35MP0003786_premature_aging1.39549869
36MP0009764_decreased_sensitivity_to1.38524056
37MP0008007_abnormal_cellular_replicative1.37613026
38MP0002938_white_spotting1.33256242
39MP0005174_abnormal_tail_pigmentation1.29853475
40MP0005646_abnormal_pituitary_gland1.29067720
41MP0005084_abnormal_gallbladder_morpholo1.28787921
42MP0008872_abnormal_physiological_respon1.28483477
43MP0005645_abnormal_hypothalamus_physiol1.22386411
44MP0000465_gastrointestinal_hemorrhage1.22202966
45MP0002095_abnormal_skin_pigmentation1.19662947
46MP0002723_abnormal_immune_serum1.17486649
47MP0001485_abnormal_pinna_reflex1.15101667
48MP0003656_abnormal_erythrocyte_physiolo1.15004398
49MP0006072_abnormal_retinal_apoptosis1.11982995
50MP0000566_synostosis1.11402326
51MP0002452_abnormal_antigen_presenting1.11346625
52MP0002398_abnormal_bone_marrow1.08942177
53MP0002837_dystrophic_cardiac_calcinosis1.08785961
54MP0001119_abnormal_female_reproductive1.08103126
55MP0004808_abnormal_hematopoietic_stem1.07479678
56MP0003941_abnormal_skin_development1.06647938
57MP0009046_muscle_twitch1.05656091
58MP0002420_abnormal_adaptive_immunity1.04797916
59MP0005310_abnormal_salivary_gland1.04664263
60MP0003937_abnormal_limbs/digits/tail_de1.04300959
61MP0001819_abnormal_immune_cell1.03004135
62MP0006035_abnormal_mitochondrial_morpho1.00678417
63MP0005253_abnormal_eye_physiology0.99767592
64MP0009697_abnormal_copulation0.99272506
65MP0002638_abnormal_pupillary_reflex0.98959704
66MP0001986_abnormal_taste_sensitivity0.98832146
67MP0000689_abnormal_spleen_morphology0.98463807
68MP0001293_anophthalmia0.97396577
69MP0005075_abnormal_melanosome_morpholog0.94039995
70MP0003122_maternal_imprinting0.93551130
71MP0001529_abnormal_vocalization0.93323244
72MP0008004_abnormal_stomach_pH0.93064245
73MP0003183_abnormal_peptide_metabolism0.92435566
74MP0002272_abnormal_nervous_system0.92392579
75MP0005551_abnormal_eye_electrophysiolog0.92150299
76MP0000631_abnormal_neuroendocrine_gland0.91719237
77MP0002736_abnormal_nociception_after0.91388159
78MP0001502_abnormal_circadian_rhythm0.90868568
79MP0003303_peritoneal_inflammation0.90493314
80MP0001919_abnormal_reproductive_system0.89866699
81MP0003718_maternal_effect0.89340906
82MP0005000_abnormal_immune_tolerance0.89155174
83MP0009250_abnormal_appendicular_skeleto0.89057062
84MP0002148_abnormal_hypersensitivity_rea0.88079327
85MP0000716_abnormal_immune_system0.88063567
86MP0002282_abnormal_trachea_morphology0.87625858
87MP0005389_reproductive_system_phenotype0.86243526
88MP0008932_abnormal_embryonic_tissue0.86083620
89MP0009785_altered_susceptibility_to0.85432671
90MP0000685_abnormal_immune_system0.84070665
91MP0001486_abnormal_startle_reflex0.83764384
92MP0000230_abnormal_systemic_arterial0.83152265
93MP0005187_abnormal_penis_morphology0.82659636
94MP0002419_abnormal_innate_immunity0.81980777
95MP0004883_abnormal_blood_vessel0.81563595
96MP0004484_altered_response_of0.80451260
97MP0000372_irregular_coat_pigmentation0.80205708
98MP0000490_abnormal_crypts_of0.79758682
99MP0002735_abnormal_chemical_nociception0.79374007
100MP0002722_abnormal_immune_system0.78876003
101MP0001984_abnormal_olfaction0.78440395
102MP0000427_abnormal_hair_cycle0.78256410
103MP0000026_abnormal_inner_ear0.78028901
104MP0005423_abnormal_somatic_nervous0.77527834
105MP0002733_abnormal_thermal_nociception0.76956422
106MP0001970_abnormal_pain_threshold0.76848378
107MP0005266_abnormal_metabolism0.76682236
108MP0000383_abnormal_hair_follicle0.76423244
109MP0004134_abnormal_chest_morphology0.75110922
110MP0005171_absent_coat_pigmentation0.75050481
111MP0002009_preneoplasia0.74964760
112MP0000703_abnormal_thymus_morphology0.74490597
113MP0005167_abnormal_blood-brain_barrier0.74416409
114MP0003880_abnormal_central_pattern0.73980327
115MP0002928_abnormal_bile_duct0.73858338
116MP0002177_abnormal_outer_ear0.73711684
117MP0004885_abnormal_endolymph0.73542230
118MP0005397_hematopoietic_system_phenotyp0.72531632
119MP0001545_abnormal_hematopoietic_system0.72531632
120MP0001324_abnormal_eye_pigmentation0.72457485
121MP0000778_abnormal_nervous_system0.70628144
122MP0005379_endocrine/exocrine_gland_phen0.68253352
123MP0001963_abnormal_hearing_physiology0.66477531
124MP0006276_abnormal_autonomic_nervous0.66465348
125MP0005391_vision/eye_phenotype0.66343318
126MP0002234_abnormal_pharynx_morphology0.64963617
127MP0002163_abnormal_gland_morphology0.64943892
128MP0005647_abnormal_sex_gland0.64797879
129MP0000432_abnormal_head_morphology0.64435797
130MP0002572_abnormal_emotion/affect_behav0.64125046
131MP0004742_abnormal_vestibular_system0.64074701
132MP0002277_abnormal_respiratory_mucosa0.63610929
133MP0000462_abnormal_digestive_system0.61525126
134MP0002116_abnormal_craniofacial_bone0.60843268
135MP0000049_abnormal_middle_ear0.58203079
136MP0004381_abnormal_hair_follicle0.58041818
137MP0002876_abnormal_thyroid_physiology0.57698011
138MP0002557_abnormal_social/conspecific_i0.57281562
139MP0001270_distended_abdomen0.57169553
140MP0005623_abnormal_meninges_morphology0.56818873
141MP0001968_abnormal_touch/_nociception0.56383617
142MP0002109_abnormal_limb_morphology0.55428429
143MP0002075_abnormal_coat/hair_pigmentati0.55369163
144MP0003699_abnormal_female_reproductive0.54694102
145MP0003123_paternal_imprinting0.54352121
146MP0001765_abnormal_ion_homeostasis0.52927299
147MP0001286_abnormal_eye_development0.51364791
148MP0009745_abnormal_behavioral_response0.51059726
149MP0002067_abnormal_sensory_capabilities0.50961774
150MP0001186_pigmentation_phenotype0.50645712

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.08029034
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.72505367
3Absent/shortened dynein arms (HP:0200106)8.72505367
4Abnormal respiratory motile cilium physiology (HP:0012261)7.38101609
5Abnormal ciliary motility (HP:0012262)7.04759340
6Abnormal respiratory epithelium morphology (HP:0012253)6.69685906
7Abnormal respiratory motile cilium morphology (HP:0005938)6.69685906
8Rhinitis (HP:0012384)5.54646198
9Nephronophthisis (HP:0000090)4.06038753
10Chronic bronchitis (HP:0004469)4.05153806
11Infertility (HP:0000789)3.65152649
12Bronchiectasis (HP:0002110)3.64496772
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.42513545
14Abnormality of the renal medulla (HP:0100957)3.42436034
15Tubulointerstitial nephritis (HP:0001970)3.39926367
16Hyperventilation (HP:0002883)3.37644401
17Chromsome breakage (HP:0040012)3.35957354
18Molar tooth sign on MRI (HP:0002419)3.11032757
19Abnormality of midbrain morphology (HP:0002418)3.11032757
20True hermaphroditism (HP:0010459)3.06931879
21Prolonged bleeding time (HP:0003010)2.96751669
22Recurrent sinusitis (HP:0011108)2.91074354
23Pancreatic fibrosis (HP:0100732)2.90332463
24Chronic hepatic failure (HP:0100626)2.85853222
25Medial flaring of the eyebrow (HP:0010747)2.79866170
26Abnormal hair whorl (HP:0010721)2.72010711
27Postaxial foot polydactyly (HP:0001830)2.68679135
28Nasal polyposis (HP:0100582)2.65104932
29Bronchitis (HP:0012387)2.52970723
30Stomatitis (HP:0010280)2.49359167
31Congenital hepatic fibrosis (HP:0002612)2.47768794
32Stomach cancer (HP:0012126)2.43285147
33Abnormal spermatogenesis (HP:0008669)2.42094760
34Hypothermia (HP:0002045)2.38917100
35Pancreatic cysts (HP:0001737)2.34640112
36Median cleft lip (HP:0000161)2.34491978
37Abnormality of chromosome stability (HP:0003220)2.31363700
38Genetic anticipation (HP:0003743)2.29021553
39Renal dysplasia (HP:0000110)2.26356195
40Occipital encephalocele (HP:0002085)2.26025826
41Male infertility (HP:0003251)2.23710307
42Gaze-evoked nystagmus (HP:0000640)2.22275332
43Hypochromic microcytic anemia (HP:0004840)2.19142273
44Supernumerary spleens (HP:0009799)2.18506688
45Abnormality of the renal cortex (HP:0011035)2.18394262
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.18156733
47Volvulus (HP:0002580)2.17872850
48Facial cleft (HP:0002006)2.16822639
49Oligodactyly (hands) (HP:0001180)2.15161888
50Preaxial hand polydactyly (HP:0001177)2.11276047
51Nephroblastoma (Wilms tumor) (HP:0002667)2.10950337
52Abnormality of the preputium (HP:0100587)2.10509938
53Congenital stationary night blindness (HP:0007642)2.06956735
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06934399
55Progressive cerebellar ataxia (HP:0002073)2.06762140
563-Methylglutaconic aciduria (HP:0003535)2.06338728
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.05551734
58Congenital primary aphakia (HP:0007707)2.04677397
59Increased mean platelet volume (HP:0011877)2.02336995
60Abolished electroretinogram (ERG) (HP:0000550)2.01951299
61Bell-shaped thorax (HP:0001591)2.01850339
62Protruding tongue (HP:0010808)2.01641803
63Ectopic kidney (HP:0000086)2.01316199
64Fibular hypoplasia (HP:0003038)2.00458889
65Gait imbalance (HP:0002141)2.00003939
66Attenuation of retinal blood vessels (HP:0007843)1.98991896
67Recurrent otitis media (HP:0000403)1.98356316
68Meckel diverticulum (HP:0002245)1.98031338
69Progressive macrocephaly (HP:0004481)1.96482699
70Thyroiditis (HP:0100646)1.95762988
71Nephrogenic diabetes insipidus (HP:0009806)1.95004198
72Type II lissencephaly (HP:0007260)1.94582087
73Abnormal platelet volume (HP:0011876)1.94538490
74Fair hair (HP:0002286)1.94370389
75Abnormal rod and cone electroretinograms (HP:0008323)1.92507424
76Embryonal renal neoplasm (HP:0011794)1.92431810
77Lissencephaly (HP:0001339)1.92026686
78Furrowed tongue (HP:0000221)1.91010035
79Petechiae (HP:0000967)1.88730676
80Abnormality of the ileum (HP:0001549)1.88131643
81Hypoplastic iliac wings (HP:0002866)1.87850293
82Intestinal atresia (HP:0011100)1.87383579
83Papillary thyroid carcinoma (HP:0002895)1.87008912
84Gingival bleeding (HP:0000225)1.86524045
85Neoplasm of the adrenal cortex (HP:0100641)1.86245068
86Encephalitis (HP:0002383)1.85957497
87Postaxial hand polydactyly (HP:0001162)1.85512019
88Recurrent bacterial skin infections (HP:0005406)1.85339630
89Abnormality of T cell number (HP:0011839)1.83613833
90Cystic liver disease (HP:0006706)1.82361243
91Congenital, generalized hypertrichosis (HP:0004540)1.82248375
92Decreased central vision (HP:0007663)1.82183460
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.82170736
94Retinal dysplasia (HP:0007973)1.82110905
95Male pseudohermaphroditism (HP:0000037)1.81170944
96Abnormality of the nasal mucosa (HP:0000433)1.80862048
97Abnormality of the renal collecting system (HP:0004742)1.80614663
98Epistaxis (HP:0000421)1.80214788
99Azoospermia (HP:0000027)1.80045565
100Widely spaced teeth (HP:0000687)1.79487014
101Tubulointerstitial abnormality (HP:0001969)1.79482089
102Sloping forehead (HP:0000340)1.79416092
103Chronic sinusitis (HP:0011109)1.79163631
104Methylmalonic acidemia (HP:0002912)1.78874371
105Poikilocytosis (HP:0004447)1.78677197
106Anencephaly (HP:0002323)1.78655531
107Aqueductal stenosis (HP:0002410)1.78116045
108Prostate neoplasm (HP:0100787)1.77478964
109Acute necrotizing encephalopathy (HP:0006965)1.77463542
110Sclerocornea (HP:0000647)1.76889964
111Drooling (HP:0002307)1.76787637
112T lymphocytopenia (HP:0005403)1.76096765
113Febrile seizures (HP:0002373)1.76057871
114Keratoconjunctivitis (HP:0001096)1.75735148
115Duplicated collecting system (HP:0000081)1.74726025
116Limb hypertonia (HP:0002509)1.74558755
117Acanthocytosis (HP:0001927)1.74453745
118Dyschromatopsia (HP:0007641)1.73548791
119Tubular atrophy (HP:0000092)1.73316022
120Progressive inability to walk (HP:0002505)1.73264950
121IgG deficiency (HP:0004315)1.72600977
122Keratoconjunctivitis sicca (HP:0001097)1.71151624
123Abnormal biliary tract physiology (HP:0012439)1.69019382
124Bile duct proliferation (HP:0001408)1.69019382
125Excessive salivation (HP:0003781)1.68504698
126Abnormality of the heme biosynthetic pathway (HP:0010472)1.68158176
127Astigmatism (HP:0000483)1.67696661
128Genital tract atresia (HP:0001827)1.67559304
129Acute encephalopathy (HP:0006846)1.66797628
130Clubbing of toes (HP:0100760)1.66099329
131Recurrent fungal infections (HP:0002841)1.65707811
132Polydipsia (HP:0001959)1.64967484
133Abnormal drinking behavior (HP:0030082)1.64967484
134Abnormality of DNA repair (HP:0003254)1.63544999
135Absent speech (HP:0001344)1.63199536
136Severe visual impairment (HP:0001141)1.62670905
137Poor coordination (HP:0002370)1.62148900
138Renal cortical cysts (HP:0000803)1.62017595
139Vaginal atresia (HP:0000148)1.60821371
140Absent frontal sinuses (HP:0002688)1.59707739
141Optic nerve hypoplasia (HP:0000609)1.58311815
142Abnormality of incisor morphology (HP:0011063)1.54328161
143Stage 5 chronic kidney disease (HP:0003774)1.54005311
144Aplasia cutis congenita (HP:0001057)1.51950987
145Recurrent bronchitis (HP:0002837)1.51515335
146Aplasia/Hypoplasia of the lens (HP:0008063)1.51302270
147Lip pit (HP:0100267)1.50830273
148Retrobulbar optic neuritis (HP:0100654)1.50570088
149Optic neuritis (HP:0100653)1.50570088
15011 pairs of ribs (HP:0000878)1.49245766
151Myelodysplasia (HP:0002863)1.48685254
152Abnormality of the carotid arteries (HP:0005344)1.48682734
153Duodenal stenosis (HP:0100867)1.47777551
154Small intestinal stenosis (HP:0012848)1.47777551
155Acute myeloid leukemia (HP:0004808)1.46448241
156Acute lymphatic leukemia (HP:0006721)1.45800796
157White forelock (HP:0002211)1.43978780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.42561187
2PDK44.42561187
3PNCK3.02644430
4CASK2.61048944
5PDK22.49597461
6CDC72.44665929
7TNIK2.26084996
8CAMK1G2.13305616
9INSRR2.08075827
10TLK12.00682811
11NUAK11.97859739
12MST41.89480836
13CDK31.78818469
14MKNK21.74237015
15SRPK11.69318114
16MAP4K21.68139839
17MAP2K71.68126292
18MAP3K61.61527100
19NEK21.61284492
20BMPR21.56599968
21EIF2AK21.56397273
22CHEK21.55679645
23BLK1.55643367
24YES11.53570793
25BRD41.52718183
26VRK11.52173871
27RIPK41.47998707
28PLK41.37968306
29CAMK1D1.37964124
30OXSR11.37871089
31STK31.37630872
32ZAK1.35190687
33STK38L1.34779669
34TTK1.34762856
35PRKD31.32098160
36MKNK11.31194989
37PIK3CG1.29152457
38ERBB31.28334081
39ATR1.27488604
40MAPK151.27042886
41PINK11.22075638
42IRAK11.19261083
43GRK61.14972766
44ATM1.14528573
45PAK31.11975145
46SYK1.09841798
47STK161.08493523
48IKBKE1.05591366
49DYRK31.04350177
50MUSK0.99070498
51TEC0.98844796
52CCNB10.98614616
53ADRBK10.97696246
54FGR0.96381859
55MAP3K120.95223933
56BRSK20.94517374
57WNK40.93557627
58EIF2AK10.90958376
59PASK0.90518307
60CHEK10.89852354
61MARK30.89423701
62MAP3K40.89343003
63LYN0.89278445
64CDK190.88637066
65PLK10.87850811
66LATS10.85440853
67NEK60.84425023
68BMPR1B0.80903951
69WEE10.80656219
70TAOK30.80349116
71IRAK40.79288585
72MAPK130.78003706
73TRIM280.75935687
74WNK10.74201685
75CDK90.73429194
76CDK120.73261488
77AKT30.72113669
78CSK0.71605097
79MAP3K140.70546763
80PLK30.68871854
81SIK20.68840820
82IKBKB0.68412470
83IRAK20.68266508
84BCR0.68265662
85BRAF0.67848974
86MATK0.66688786
87PIM10.64578996
88GRK50.61862123
89ERBB20.61014336
90PTK2B0.60881262
91SGK20.59241286
92STK110.59238136
93ADRBK20.58708967
94PLK20.58638921
95STK380.57544021
96MAP3K20.56482160
97ITK0.55955383
98DYRK1A0.55652167
99MAP2K40.55632748
100AURKB0.54921887
101CSF1R0.54363548
102RPS6KB10.53197654
103CAMKK20.52829483
104PKN10.52112858
105RPS6KA50.51009207
106WNK30.50393487
107EIF2AK30.49986671
108STK390.49785526
109CDK10.48813313
110NTRK30.48378005
111BTK0.48295431
112HCK0.47336075
113FRK0.47322452
114STK40.47288649
115RAF10.47157253
116STK240.46895725
117CSNK1G20.46251099
118JAK20.46112093
119CHUK0.45546663
120FES0.45406565
121PRKCQ0.43547863
122TXK0.43231928
123TGFBR10.43160640
124PRKG10.42384655
125DYRK20.42102770
126PRKDC0.41580783
127KIT0.40963204
128SGK10.40395538
129NTRK20.38156576
130ACVR1B0.35979272
131PRKCE0.35559907
132NLK0.33847058
133GRK10.33224868
134EPHA30.32081754
135GSK3B0.31921194
136MAPKAPK50.31881512
137CDK40.31858669
138CDK20.31371210
139IRAK30.30690928
140CDK70.30142485
141PBK0.29010535

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.79797292
2Fanconi anemia pathway_Homo sapiens_hsa034603.66699230
3Non-homologous end-joining_Homo sapiens_hsa034502.81191370
4Homologous recombination_Homo sapiens_hsa034402.60338547
5Basal transcription factors_Homo sapiens_hsa030222.49969898
6Nicotine addiction_Homo sapiens_hsa050332.12910164
7Cell cycle_Homo sapiens_hsa041101.92623157
8Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.81548908
9Mismatch repair_Homo sapiens_hsa034301.77152275
10DNA replication_Homo sapiens_hsa030301.76044664
11Nucleotide excision repair_Homo sapiens_hsa034201.73184192
12Platelet activation_Homo sapiens_hsa046111.72282015
13Olfactory transduction_Homo sapiens_hsa047401.52969133
14Nitrogen metabolism_Homo sapiens_hsa009101.51451420
15RNA degradation_Homo sapiens_hsa030181.50000890
16Regulation of autophagy_Homo sapiens_hsa041401.44572445
17mRNA surveillance pathway_Homo sapiens_hsa030151.42930813
18Pyrimidine metabolism_Homo sapiens_hsa002401.40152318
19Purine metabolism_Homo sapiens_hsa002301.37395415
20Systemic lupus erythematosus_Homo sapiens_hsa053221.32496821
21Taste transduction_Homo sapiens_hsa047421.31758728
22Oxidative phosphorylation_Homo sapiens_hsa001901.29042007
23Linoleic acid metabolism_Homo sapiens_hsa005911.28478238
24RNA transport_Homo sapiens_hsa030131.27264647
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26621225
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24852520
27Base excision repair_Homo sapiens_hsa034101.24838951
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20376997
29Parkinsons disease_Homo sapiens_hsa050121.20141479
30Oocyte meiosis_Homo sapiens_hsa041141.19036901
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16253589
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12846529
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10755662
34Amphetamine addiction_Homo sapiens_hsa050311.09813674
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06877330
36Spliceosome_Homo sapiens_hsa030401.06862932
37RNA polymerase_Homo sapiens_hsa030201.01095172
38Phototransduction_Homo sapiens_hsa047441.01007455
39Chemokine signaling pathway_Homo sapiens_hsa040620.99448193
40Herpes simplex infection_Homo sapiens_hsa051680.99290368
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99225067
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.99163675
43Dorso-ventral axis formation_Homo sapiens_hsa043200.98450664
44Leishmaniasis_Homo sapiens_hsa051400.97177646
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95292156
46Morphine addiction_Homo sapiens_hsa050320.92766870
47Type I diabetes mellitus_Homo sapiens_hsa049400.92443799
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91527881
49GABAergic synapse_Homo sapiens_hsa047270.91146706
50Selenocompound metabolism_Homo sapiens_hsa004500.90094200
51Butanoate metabolism_Homo sapiens_hsa006500.89984318
52Arachidonic acid metabolism_Homo sapiens_hsa005900.89589859
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89486897
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89379637
55Ether lipid metabolism_Homo sapiens_hsa005650.88344234
56Protein export_Homo sapiens_hsa030600.86947808
57Glutamatergic synapse_Homo sapiens_hsa047240.86879104
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86739901
59T cell receptor signaling pathway_Homo sapiens_hsa046600.85974219
60Huntingtons disease_Homo sapiens_hsa050160.83793542
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.82507826
62Renin secretion_Homo sapiens_hsa049240.82180359
63Circadian entrainment_Homo sapiens_hsa047130.82047852
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.81094348
65Vitamin B6 metabolism_Homo sapiens_hsa007500.80260104
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79997854
67Measles_Homo sapiens_hsa051620.79698674
68Serotonergic synapse_Homo sapiens_hsa047260.79652529
69Calcium signaling pathway_Homo sapiens_hsa040200.78507369
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77787219
71Propanoate metabolism_Homo sapiens_hsa006400.77612943
72Autoimmune thyroid disease_Homo sapiens_hsa053200.76102379
73Inositol phosphate metabolism_Homo sapiens_hsa005620.75949556
74Osteoclast differentiation_Homo sapiens_hsa043800.74811596
75Alcoholism_Homo sapiens_hsa050340.74403163
76cAMP signaling pathway_Homo sapiens_hsa040240.73444661
77Tuberculosis_Homo sapiens_hsa051520.72976246
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71801080
79Legionellosis_Homo sapiens_hsa051340.71791494
80Insulin secretion_Homo sapiens_hsa049110.71112422
81Primary immunodeficiency_Homo sapiens_hsa053400.70930932
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70403836
83Sulfur metabolism_Homo sapiens_hsa009200.70340588
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69220990
85Tryptophan metabolism_Homo sapiens_hsa003800.68375619
86Cholinergic synapse_Homo sapiens_hsa047250.67194016
87One carbon pool by folate_Homo sapiens_hsa006700.66960476
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66928652
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66414987
90FoxO signaling pathway_Homo sapiens_hsa040680.66215360
91Epstein-Barr virus infection_Homo sapiens_hsa051690.64270782
92Wnt signaling pathway_Homo sapiens_hsa043100.62574787
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62398932
94Sphingolipid metabolism_Homo sapiens_hsa006000.61574415
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60934583
96Dopaminergic synapse_Homo sapiens_hsa047280.60180629
97Alzheimers disease_Homo sapiens_hsa050100.60174805
98Staphylococcus aureus infection_Homo sapiens_hsa051500.59841766
99ABC transporters_Homo sapiens_hsa020100.58937990
100Hedgehog signaling pathway_Homo sapiens_hsa043400.58875851
101Hematopoietic cell lineage_Homo sapiens_hsa046400.58334402
102Viral carcinogenesis_Homo sapiens_hsa052030.56598723
103Allograft rejection_Homo sapiens_hsa053300.56346335
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.56104452
105p53 signaling pathway_Homo sapiens_hsa041150.55827242
106Ovarian steroidogenesis_Homo sapiens_hsa049130.54826339
107Graft-versus-host disease_Homo sapiens_hsa053320.53559243
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53222109
109Glucagon signaling pathway_Homo sapiens_hsa049220.52890423
110Long-term potentiation_Homo sapiens_hsa047200.52493425
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51542642
112Glycerolipid metabolism_Homo sapiens_hsa005610.51034407
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50830437
114Malaria_Homo sapiens_hsa051440.48941128
115HTLV-I infection_Homo sapiens_hsa051660.48715018
116Salivary secretion_Homo sapiens_hsa049700.47737783
117Circadian rhythm_Homo sapiens_hsa047100.46872202
118Influenza A_Homo sapiens_hsa051640.46629530
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45850033
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45421936
121Asthma_Homo sapiens_hsa053100.44642810
122Cocaine addiction_Homo sapiens_hsa050300.44309976
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42700873
124Peroxisome_Homo sapiens_hsa041460.40608773
125Basal cell carcinoma_Homo sapiens_hsa052170.39937679
126Antigen processing and presentation_Homo sapiens_hsa046120.39884486
127MAPK signaling pathway_Homo sapiens_hsa040100.39538533
128African trypanosomiasis_Homo sapiens_hsa051430.38842340
129Long-term depression_Homo sapiens_hsa047300.38167639
130Rheumatoid arthritis_Homo sapiens_hsa053230.37741273
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.36756645
132TNF signaling pathway_Homo sapiens_hsa046680.36535890
133B cell receptor signaling pathway_Homo sapiens_hsa046620.35717920
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33648098
135Collecting duct acid secretion_Homo sapiens_hsa049660.33454310
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32719226
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32342374
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.32228080

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