SCGB2A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular ketone body metabolic process (GO:0046950)5.23227737
2regulation of type B pancreatic cell apoptotic process (GO:2000674)4.71739662
3ketone body metabolic process (GO:1902224)4.61961798
4endocrine pancreas development (GO:0031018)4.51689105
5insulin secretion (GO:0030073)4.44089103
6peptide hormone processing (GO:0016486)4.31064543
7L-alpha-amino acid transmembrane transport (GO:1902475)4.28520180
8negative regulation of execution phase of apoptosis (GO:1900118)4.27389191
9auditory receptor cell differentiation (GO:0042491)4.14487018
10positive regulation of glycolytic process (GO:0045821)4.13431336
11glycerophospholipid catabolic process (GO:0046475)4.12991068
12positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.02353243
13inositol phosphate catabolic process (GO:0071545)4.01821677
14negative regulation of cytosolic calcium ion concentration (GO:0051481)4.00692745
15regulation of glucokinase activity (GO:0033131)3.98869126
16regulation of hexokinase activity (GO:1903299)3.98869126
17epithelial cell fate commitment (GO:0072148)3.97728402
18positive regulation of insulin secretion (GO:0032024)3.84382551
19phosphorylated carbohydrate dephosphorylation (GO:0046838)3.79607827
20inositol phosphate dephosphorylation (GO:0046855)3.79607827
21water-soluble vitamin biosynthetic process (GO:0042364)3.77347832
22lactate metabolic process (GO:0006089)3.77015830
23positive regulation of gluconeogenesis (GO:0045722)3.74491984
24detection of calcium ion (GO:0005513)3.69913895
25nitric oxide biosynthetic process (GO:0006809)3.59254661
26nitric oxide mediated signal transduction (GO:0007263)3.52262609
27signal peptide processing (GO:0006465)3.49968885
28sphingomyelin metabolic process (GO:0006684)3.45751643
29positive regulation of peptide hormone secretion (GO:0090277)3.44569233
30respiratory chain complex IV assembly (GO:0008535)3.40910554
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.40786510
32L-phenylalanine catabolic process (GO:0006559)3.40786510
33polyol catabolic process (GO:0046174)3.39400536
34cytochrome complex assembly (GO:0017004)3.39300552
35zinc ion homeostasis (GO:0055069)3.38635767
36glandular epithelial cell differentiation (GO:0002067)3.33579112
37positive regulation of peptide secretion (GO:0002793)3.30239444
38negative regulation of neurological system process (GO:0031645)3.25997909
39regulation of autophagic vacuole assembly (GO:2000785)3.25277303
40negative regulation of hormone biosynthetic process (GO:0032353)3.18173180
41regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.17976720
42positive regulation of calcium ion import (GO:0090280)3.13865999
43axoneme assembly (GO:0035082)3.12542440
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.05086324
45L-phenylalanine metabolic process (GO:0006558)3.05086324
46macroautophagy (GO:0016236)3.03858602
47nephron epithelium morphogenesis (GO:0072088)3.03540692
48nephron tubule morphogenesis (GO:0072078)3.03540692
49positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.02955472
50negative regulation of protein oligomerization (GO:0032460)3.02377606
51regulation of insulin secretion (GO:0050796)2.98025861
52prostate gland growth (GO:0060736)2.96370999
53zinc ion transmembrane transport (GO:0071577)2.95304722
54peptide hormone secretion (GO:0030072)2.91931550
55regulation of energy homeostasis (GO:2000505)2.91754773
56negative regulation of complement activation (GO:0045916)2.89646897
57positive regulation of macroautophagy (GO:0016239)2.87836492
58positive regulation of histone H3-K4 methylation (GO:0051571)2.87095510
59peptide secretion (GO:0002790)2.84199406
60cellular zinc ion homeostasis (GO:0006882)2.82645379
61proline transport (GO:0015824)2.79350800
62chemosensory behavior (GO:0007635)2.79199634
63renal tubule morphogenesis (GO:0061333)2.78543517
64positive regulation of meiosis (GO:0045836)2.78246663
65positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.77614060
66negative regulation of hormone metabolic process (GO:0032351)2.77107462
67regulation of peptide hormone secretion (GO:0090276)2.76986710
68Golgi to endosome transport (GO:0006895)2.76674819
69purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.75788258
703-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.75788258
71zinc ion transport (GO:0006829)2.75157191
72regulation of vacuole organization (GO:0044088)2.74274762
73retinol metabolic process (GO:0042572)2.74114522
74alanine transport (GO:0032328)2.73350465
75dendritic spine morphogenesis (GO:0060997)2.72514963
76parturition (GO:0007567)2.71932799
77regulation of peptide secretion (GO:0002791)2.70347627
78phenylpropanoid metabolic process (GO:0009698)2.68233355
79dentate gyrus development (GO:0021542)2.67075026
80potassium ion export (GO:0071435)2.64524032
81aromatic amino acid family catabolic process (GO:0009074)2.64232273
82astrocyte differentiation (GO:0048708)2.62943440
83protein localization to cilium (GO:0061512)2.61142621
84regulation of acrosome reaction (GO:0060046)2.61121076
85positive regulation of response to nutrient levels (GO:0032109)2.60762300
86positive regulation of response to extracellular stimulus (GO:0032106)2.60762300
87nodal signaling pathway (GO:0038092)2.60335415
88regulation of heart rate by cardiac conduction (GO:0086091)2.59937925
89positive regulation of hormone secretion (GO:0046887)2.59505437
90positive regulation of meiotic cell cycle (GO:0051446)2.58837863
91toxin transport (GO:1901998)2.58060190
92regulation of Rac protein signal transduction (GO:0035020)2.57194831
93response to dietary excess (GO:0002021)2.55633103
94magnesium ion transport (GO:0015693)2.54325415
95negative regulation of protein activation cascade (GO:2000258)2.53879466
96kidney morphogenesis (GO:0060993)2.52388185
97brain morphogenesis (GO:0048854)2.52156035
98protein complex biogenesis (GO:0070271)2.52019006
99epithelial cilium movement (GO:0003351)2.51212886
100regulation of hormone secretion (GO:0046883)2.49417534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human2.48934854
2POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40625285
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19946298
4IGF1R_20145208_ChIP-Seq_DFB_Human2.08220196
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.8372391
6ZNF274_21170338_ChIP-Seq_K562_Hela1.98214522
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93215630
8FLI1_27457419_Chip-Seq_LIVER_Mouse1.90052318
9EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.88423013
10AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78801883
11PIAS1_25552417_ChIP-Seq_VCAP_Human1.77644147
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71945956
13TAF15_26573619_Chip-Seq_HEK293_Human1.69956044
14HTT_18923047_ChIP-ChIP_STHdh_Human1.68551691
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67968886
16P300_19829295_ChIP-Seq_ESCs_Human1.66078858
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62245166
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62181961
19SMAD4_21799915_ChIP-Seq_A2780_Human1.61650497
20VDR_22108803_ChIP-Seq_LS180_Human1.60925187
21FUS_26573619_Chip-Seq_HEK293_Human1.59173601
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54318071
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47806432
24RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46300583
25AR_25329375_ChIP-Seq_VCAP_Human1.46159603
26BCAT_22108803_ChIP-Seq_LS180_Human1.45272771
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44846627
28ER_23166858_ChIP-Seq_MCF-7_Human1.40101280
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40089454
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39809751
31STAT3_23295773_ChIP-Seq_U87_Human1.38613029
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37441247
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.35336629
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.34350134
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33634248
36CDX2_22108803_ChIP-Seq_LS180_Human1.31966515
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31344442
38* TP53_22573176_ChIP-Seq_HFKS_Human1.31178019
39EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28903380
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28539019
41* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26322925
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25795028
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24324023
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.24030301
45TCF4_23295773_ChIP-Seq_U87_Human1.23404471
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20680527
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19895465
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19091248
49P53_22387025_ChIP-Seq_ESCs_Mouse1.18899758
50SOX2_18555785_Chip-Seq_ESCs_Mouse1.15331424
51STAT3_18555785_Chip-Seq_ESCs_Mouse1.14678603
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14532560
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.14392829
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14265628
55CBP_20019798_ChIP-Seq_JUKART_Human1.14244606
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14244606
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12727885
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12232462
59FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.10903185
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09861670
61EWS_26573619_Chip-Seq_HEK293_Human1.09789549
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.09616172
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09616172
64* FOXA1_25552417_ChIP-Seq_VCAP_Human1.09574249
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.09271042
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08557396
67SOX2_19829295_ChIP-Seq_ESCs_Human1.07923770
68NANOG_19829295_ChIP-Seq_ESCs_Human1.07923770
69EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07520455
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.07516869
71TCF4_22108803_ChIP-Seq_LS180_Human1.07343859
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.06526920
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04101087
74REST_21632747_ChIP-Seq_MESCs_Mouse1.02564608
75AR_20517297_ChIP-Seq_VCAP_Human1.02473857
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01911609
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.01720674
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00173880
79RUNX2_22187159_ChIP-Seq_PCA_Human1.00079945
80CTCF_18555785_Chip-Seq_ESCs_Mouse0.99954713
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99943519
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99683796
83P300_18555785_Chip-Seq_ESCs_Mouse0.99591332
84EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99127699
85* SMAD4_21741376_ChIP-Seq_EPCs_Human0.98088107
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97234283
87NMYC_18555785_Chip-Seq_ESCs_Mouse0.96229331
88SOX2_21211035_ChIP-Seq_LN229_Gbm0.96228644
89SOX2_20726797_ChIP-Seq_SW620_Human0.96186329
90KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94949705
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94284136
92TBL1_22424771_ChIP-Seq_293T_Human0.94229839
93FLI1_21867929_ChIP-Seq_TH2_Mouse0.93892010
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93452438
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.93353596
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.93330337
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93151558
98NCOR_22424771_ChIP-Seq_293T_Human0.93103050
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92517349
100OCT4_18555785_Chip-Seq_ESCs_Mouse0.92226316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.65757465
2MP0005379_endocrine/exocrine_gland_phen4.33957854
3MP0009780_abnormal_chondrocyte_physiolo4.12894841
4MP0002163_abnormal_gland_morphology3.71078106
5MP0003195_calcinosis3.60100654
6MP0002254_reproductive_system_inflammat3.57734278
7MP0010386_abnormal_urinary_bladder3.42398851
8MP0002909_abnormal_adrenal_gland3.37855736
9MP0003787_abnormal_imprinting3.33616887
10MP0005645_abnormal_hypothalamus_physiol2.76478967
11MP0001944_abnormal_pancreas_morphology2.74194217
12MP0010234_abnormal_vibrissa_follicle2.73899269
13MP0000013_abnormal_adipose_tissue2.66665222
14MP0002693_abnormal_pancreas_physiology2.61894253
15MP0002876_abnormal_thyroid_physiology2.41092698
16MP0002139_abnormal_hepatobiliary_system2.21003970
17MP0005646_abnormal_pituitary_gland2.20191011
18MP0004019_abnormal_vitamin_homeostasis2.10355486
19MP0003283_abnormal_digestive_organ2.08314424
20MP0003122_maternal_imprinting2.06132500
21MP0008877_abnormal_DNA_methylation2.00997394
22MP0009046_muscle_twitch1.95646469
23MP0001756_abnormal_urination1.90410603
24MP0006072_abnormal_retinal_apoptosis1.85774737
25MP0010329_abnormal_lipoprotein_level1.82735553
26MP0005220_abnormal_exocrine_pancreas1.72365465
27MP0005332_abnormal_amino_acid1.71540268
28MP0002078_abnormal_glucose_homeostasis1.70632795
29MP0004270_analgesia1.67276129
30MP0001984_abnormal_olfaction1.64511062
31MP0003123_paternal_imprinting1.63704423
32MP0005365_abnormal_bile_salt1.58722554
33MP0004043_abnormal_pH_regulation1.54221946
34MP0002638_abnormal_pupillary_reflex1.52639142
35MP0002160_abnormal_reproductive_system1.40663336
36MP0005389_reproductive_system_phenotype1.37013776
37MP0005636_abnormal_mineral_homeostasis1.30810051
38MP0001765_abnormal_ion_homeostasis1.30272894
39MP0001501_abnormal_sleep_pattern1.26477294
40MP0000003_abnormal_adipose_tissue1.24062984
41MP0005448_abnormal_energy_balance1.21309107
42MP0003953_abnormal_hormone_level1.19887452
43MP0000631_abnormal_neuroendocrine_gland1.16666937
44MP0009745_abnormal_behavioral_response1.15528672
45MP0003172_abnormal_lysosome_physiology1.15433677
46MP0005551_abnormal_eye_electrophysiolog1.15375700
47MP0005084_abnormal_gallbladder_morpholo1.14292980
48MP0003121_genomic_imprinting1.12030801
49MP0002928_abnormal_bile_duct1.11616289
50MP0000639_abnormal_adrenal_gland1.11564901
51MP0004133_heterotaxia1.09281321
52MP0000538_abnormal_urinary_bladder1.04628204
53MP0003879_abnormal_hair_cell1.03601098
54MP0005253_abnormal_eye_physiology1.01748589
55MP0000372_irregular_coat_pigmentation1.00798121
56MP0002118_abnormal_lipid_homeostasis0.98832968
57MP0001905_abnormal_dopamine_level0.98470639
58MP0010678_abnormal_skin_adnexa0.98041169
59MP0005535_abnormal_body_temperature0.98003332
60MP0003633_abnormal_nervous_system0.96588301
61MP0002557_abnormal_social/conspecific_i0.96436474
62MP0002938_white_spotting0.95981221
63MP0002064_seizures0.94879581
64MP0002272_abnormal_nervous_system0.93018463
65MP0003868_abnormal_feces_composition0.92816142
66MP0004215_abnormal_myocardial_fiber0.92488636
67MP0005367_renal/urinary_system_phenotyp0.89897847
68MP0000516_abnormal_urinary_system0.89897847
69MP0000427_abnormal_hair_cycle0.89616187
70MP0001661_extended_life_span0.86423217
71MP0001764_abnormal_homeostasis0.85370988
72MP0002090_abnormal_vision0.85036798
73MP0005386_behavior/neurological_phenoty0.84883746
74MP0004924_abnormal_behavior0.84883746
75MP0004885_abnormal_endolymph0.84294743
76MP0001919_abnormal_reproductive_system0.83850898
77MP0005174_abnormal_tail_pigmentation0.83812771
78MP0003011_delayed_dark_adaptation0.81948736
79MP0004085_abnormal_heartbeat0.81017925
80MP0009643_abnormal_urine_homeostasis0.80651429
81MP0001502_abnormal_circadian_rhythm0.80390024
82MP0001970_abnormal_pain_threshold0.80373237
83MP0006036_abnormal_mitochondrial_physio0.77864519
84MP0008875_abnormal_xenobiotic_pharmacok0.77780120
85MP0002229_neurodegeneration0.77605142
86MP0002734_abnormal_mechanical_nocicepti0.76377736
87MP0002277_abnormal_respiratory_mucosa0.74734847
88MP0008961_abnormal_basal_metabolism0.74214275
89MP0002138_abnormal_hepatobiliary_system0.73684419
90MP0008872_abnormal_physiological_respon0.71048831
91MP0005075_abnormal_melanosome_morpholog0.68896027
92MP0002572_abnormal_emotion/affect_behav0.68820445
93MP0003252_abnormal_bile_duct0.67001395
94MP0000230_abnormal_systemic_arterial0.66562775
95MP0002069_abnormal_eating/drinking_beha0.66145301
96MP0000613_abnormal_salivary_gland0.65115541
97MP0003045_fibrosis0.65078043
98MP0010352_gastrointestinal_tract_polyps0.64707960
99MP0002733_abnormal_thermal_nociception0.63518504
100MP0002295_abnormal_pulmonary_circulatio0.63241687

Predicted human phenotypes

RankGene SetZ-score
1Ketoacidosis (HP:0001993)4.48550778
2Hypoglycemic coma (HP:0001325)4.42801181
3Hypoglycemic seizures (HP:0002173)4.34267628
4Hyperglycemia (HP:0003074)4.28528101
5Hyperinsulinemic hypoglycemia (HP:0000825)4.24127133
6Large for gestational age (HP:0001520)3.88610522
7Hypothermia (HP:0002045)3.63953447
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.52839686
9Vascular calcification (HP:0004934)3.49483411
10Ketosis (HP:0001946)3.24241387
11Intestinal atresia (HP:0011100)3.17881985
12Hemiparesis (HP:0001269)3.06951599
13Insulin-resistant diabetes mellitus (HP:0000831)3.06667142
14Hypomagnesemia (HP:0002917)3.05635256
15Enlarged penis (HP:0000040)3.03690663
16Cardiovascular calcification (HP:0011915)3.03061447
17Abnormality of vitamin B metabolism (HP:0004340)2.99960738
18Late onset (HP:0003584)2.96184530
19Abnormality of endocrine pancreas physiology (HP:0012093)2.96130882
20Abnormality of the pancreatic islet cells (HP:0006476)2.96130882
21Increased CSF protein (HP:0002922)2.85789261
22Polydipsia (HP:0001959)2.77561627
23Abnormal drinking behavior (HP:0030082)2.77561627
24Symptomatic seizures (HP:0011145)2.76396224
25Proximal tubulopathy (HP:0000114)2.74932570
26Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.70722046
27Congenital malformation of the right heart (HP:0011723)2.70467866
28Double outlet right ventricle (HP:0001719)2.70467866
29Glycosuria (HP:0003076)2.64613098
30Abnormality of urine glucose concentration (HP:0011016)2.64613098
31Pancreatic cysts (HP:0001737)2.58956202
32Tubular atrophy (HP:0000092)2.58903139
33Pancreatic fibrosis (HP:0100732)2.57036215
34Abnormality of vitamin metabolism (HP:0100508)2.51248035
35Abnormality of the renal cortex (HP:0011035)2.51064382
36Agitation (HP:0000713)2.50669876
37EEG with generalized epileptiform discharges (HP:0011198)2.45992714
38Tongue fasciculations (HP:0001308)2.44685911
39Vacuolated lymphocytes (HP:0001922)2.42782831
40Congenital sensorineural hearing impairment (HP:0008527)2.40376580
41Hamartoma of the eye (HP:0010568)2.39715965
42Epileptiform EEG discharges (HP:0011182)2.38866898
43Nephronophthisis (HP:0000090)2.38301254
44Conjunctival hamartoma (HP:0100780)2.37645153
45Hyperphosphatemia (HP:0002905)2.34803434
46Furrowed tongue (HP:0000221)2.33248930
47Medial flaring of the eyebrow (HP:0010747)2.31400132
48Abnormality of renal excretion (HP:0011036)2.30992710
49Hypsarrhythmia (HP:0002521)2.30695795
50Hypokinesia (HP:0002375)2.29111411
51Aplasia/hypoplasia of the uterus (HP:0008684)2.27886910
52Progressive macrocephaly (HP:0004481)2.27601878
53Neoplasm of the adrenal cortex (HP:0100641)2.24561097
54Abnormality of magnesium homeostasis (HP:0004921)2.24129300
55Hematochezia (HP:0002573)2.20203492
56True hermaphroditism (HP:0010459)2.18583830
57Abnormality of midbrain morphology (HP:0002418)2.16616870
58Molar tooth sign on MRI (HP:0002419)2.16616870
59Hypoalbuminemia (HP:0003073)2.14734087
60Abnormal albumin level (HP:0012116)2.14734087
61Testicular neoplasm (HP:0010788)2.12992765
62Hyperthyroidism (HP:0000836)2.12690663
63Abnormal sex determination (HP:0012244)2.12268978
64Sex reversal (HP:0012245)2.12268978
65Muscular hypotonia of the trunk (HP:0008936)2.09548498
66Abnormality of calcium-phosphate metabolism (HP:0100530)2.08964888
67Pancreatic islet-cell hyperplasia (HP:0004510)2.05749901
68Unilateral renal agenesis (HP:0000122)2.05631979
69Abnormality of the renal medulla (HP:0100957)2.04670189
70Progressive neurologic deterioration (HP:0002344)2.04429379
71Polyphagia (HP:0002591)2.02809874
72Methylmalonic acidemia (HP:0002912)2.02573526
73Abnormal pancreas size (HP:0012094)2.02355897
74Disproportionate short-trunk short stature (HP:0003521)2.01672720
75Aqueductal stenosis (HP:0002410)2.01667269
76Muscle fibrillation (HP:0010546)2.00657846
77Hypoplasia of the fovea (HP:0007750)2.00390142
78Aplasia/Hypoplasia of the fovea (HP:0008060)2.00390142
79Mitral stenosis (HP:0001718)1.98050502
80Urethral obstruction (HP:0000796)1.97159830
81Abnormal urine output (HP:0012590)1.95897806
82Renal cortical cysts (HP:0000803)1.95400664
83Increased circulating renin level (HP:0000848)1.94473525
84Type II lissencephaly (HP:0007260)1.92285705
85Polyuria (HP:0000103)1.91819706
86Gaze-evoked nystagmus (HP:0000640)1.89655989
87Neuroendocrine neoplasm (HP:0100634)1.85917057
88Methylmalonic aciduria (HP:0012120)1.81205680
89Hyperphosphaturia (HP:0003109)1.80861496
90Severe muscular hypotonia (HP:0006829)1.78922650
91Decreased circulating renin level (HP:0003351)1.78139467
92Rhinitis (HP:0012384)1.78056594
93Palpitations (HP:0001962)1.77953692
94Abnormality of renal resorption (HP:0011038)1.77433154
95Hepatic necrosis (HP:0002605)1.76707441
96Hyperventilation (HP:0002883)1.73679270
97Macroorchidism (HP:0000053)1.73049225
98Hepatoblastoma (HP:0002884)1.72530006
99Attenuation of retinal blood vessels (HP:0007843)1.71972348
100Acute necrotizing encephalopathy (HP:0006965)1.71635596

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.10668093
2FGFR23.69232965
3MST43.34090447
4MAP4K22.59270241
5PHKG12.46000528
6PHKG22.46000528
7GRK12.38444102
8STK242.16380900
9NLK2.16077656
10TRPM72.10313502
11DAPK22.07847046
12NTRK32.04389726
13ADRBK21.96118859
14FGFR31.93772263
15PAK31.90987226
16MAP2K61.88990618
17STK31.83699485
18WNK31.78823621
19PINK11.57760689
20MAP3K41.53347158
21BMPR1B1.46613874
22MAP3K21.45693729
23FER1.35840259
24PRKCE1.33690891
25INSRR1.31320554
26ACVR1B1.26273676
27ERBB31.26263115
28EPHA31.26155876
29STK38L1.19525792
30CSNK1G11.16710782
31MAPKAPK31.09389980
32PASK1.06858351
33CAMK2D1.06146116
34CASK1.03957081
35WNK40.92610024
36PNCK0.91404070
37PTK2B0.88322416
38PRKCG0.88077940
39MAP3K120.87718995
40NUAK10.86339167
41HIPK20.85425696
42IRAK10.85197704
43STK110.79807786
44PRKCI0.77362316
45PRKAA20.74805715
46YES10.73230537
47TAOK10.71774244
48CSNK1G30.70343478
49PLK20.68731771
50OXSR10.68379621
51STK390.68325577
52AKT30.64755649
53PRKAA10.63200316
54CSNK1G20.60139925
55BMPR20.58760956
56MAPK150.57055458
57ZAK0.55032070
58PDK20.54650808
59EPHB10.53600985
60GSK3A0.53366070
61MAPK130.53344211
62LATS10.51065621
63TNIK0.50924167
64MAP2K70.50865918
65PTK20.49171587
66SGK20.49054650
67TNK20.48990512
68STK160.48780741
69CAMKK20.47175527
70MKNK20.46578940
71EIF2AK30.45940830
72STK40.45578984
73CSNK1A10.41367809
74TAOK30.40618150
75PRKD20.40501268
76PIK3CA0.39757452
77PRKG10.39705773
78PRKACA0.38868730
79STK380.38767418
80TLK10.37998605
81JAK10.37608297
82CAMK2A0.37111706
83PRKCZ0.36789133
84ADRBK10.36648657
85PRKG20.36015720
86LIMK10.35176833
87SGK10.34707492
88PRKCA0.33498200
89CHUK0.33196045
90PLK30.33163563
91UHMK10.32857956
92TEC0.31530777
93PDK10.31356992
94PRKCH0.31062656
95PRKACB0.30324155
96CAMK1G0.30082341
97SGK2230.29757475
98SGK4940.29757475
99MAP2K10.29347522
100EIF2AK10.27810028

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.10358906
2Vitamin B6 metabolism_Homo sapiens_hsa007503.19520260
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.04238879
4Butanoate metabolism_Homo sapiens_hsa006502.82714394
5Sulfur metabolism_Homo sapiens_hsa009202.80185504
6Protein export_Homo sapiens_hsa030602.73556066
7Insulin secretion_Homo sapiens_hsa049112.59000318
8Collecting duct acid secretion_Homo sapiens_hsa049662.16484364
9Folate biosynthesis_Homo sapiens_hsa007902.16139085
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05218079
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92864088
12Selenocompound metabolism_Homo sapiens_hsa004501.87690708
13Oxidative phosphorylation_Homo sapiens_hsa001901.86922285
14Tryptophan metabolism_Homo sapiens_hsa003801.68997732
15Sphingolipid metabolism_Homo sapiens_hsa006001.64827760
16Type I diabetes mellitus_Homo sapiens_hsa049401.58503396
17Circadian rhythm_Homo sapiens_hsa047101.52058327
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50656557
19Fatty acid elongation_Homo sapiens_hsa000621.41193841
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41168158
21Peroxisome_Homo sapiens_hsa041461.41118801
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.37381830
23Propanoate metabolism_Homo sapiens_hsa006401.33218857
24Regulation of autophagy_Homo sapiens_hsa041401.31033391
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29901716
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26951042
27Type II diabetes mellitus_Homo sapiens_hsa049301.22051688
28Ether lipid metabolism_Homo sapiens_hsa005651.18837353
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17937288
30Synaptic vesicle cycle_Homo sapiens_hsa047211.16558371
31Mineral absorption_Homo sapiens_hsa049781.16189977
32ABC transporters_Homo sapiens_hsa020101.16109762
33Renin secretion_Homo sapiens_hsa049241.12012402
34beta-Alanine metabolism_Homo sapiens_hsa004101.06778035
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05328247
36Other glycan degradation_Homo sapiens_hsa005111.05190357
37Phototransduction_Homo sapiens_hsa047440.98917253
38Vibrio cholerae infection_Homo sapiens_hsa051100.98294590
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98280887
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96673506
41Serotonergic synapse_Homo sapiens_hsa047260.91730850
42Glycosaminoglycan degradation_Homo sapiens_hsa005310.91068847
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.88936437
44Circadian entrainment_Homo sapiens_hsa047130.88497599
45Fatty acid metabolism_Homo sapiens_hsa012120.87812345
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87240227
47Amphetamine addiction_Homo sapiens_hsa050310.87071877
48Starch and sucrose metabolism_Homo sapiens_hsa005000.85447105
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83088655
50Glucagon signaling pathway_Homo sapiens_hsa049220.83083425
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80709597
52Linoleic acid metabolism_Homo sapiens_hsa005910.80283633
53Fatty acid degradation_Homo sapiens_hsa000710.79118356
54Parkinsons disease_Homo sapiens_hsa050120.76814039
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72181123
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71215369
57Retinol metabolism_Homo sapiens_hsa008300.70441223
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70349550
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68575216
60Dopaminergic synapse_Homo sapiens_hsa047280.66510056
61Ovarian steroidogenesis_Homo sapiens_hsa049130.65736848
62Chemical carcinogenesis_Homo sapiens_hsa052040.65445984
63Lysosome_Homo sapiens_hsa041420.65133406
64Long-term depression_Homo sapiens_hsa047300.64950066
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64834845
66Salivary secretion_Homo sapiens_hsa049700.64091158
67Alzheimers disease_Homo sapiens_hsa050100.64087120
68GABAergic synapse_Homo sapiens_hsa047270.62236886
69Metabolic pathways_Homo sapiens_hsa011000.61485301
70Cardiac muscle contraction_Homo sapiens_hsa042600.61137239
71Arginine biosynthesis_Homo sapiens_hsa002200.60742389
72Nitrogen metabolism_Homo sapiens_hsa009100.59867317
73Caffeine metabolism_Homo sapiens_hsa002320.59411628
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58393382
75Histidine metabolism_Homo sapiens_hsa003400.57667659
76Cocaine addiction_Homo sapiens_hsa050300.56769164
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56270078
78Dorso-ventral axis formation_Homo sapiens_hsa043200.55308369
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53268027
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51860905
81Thyroid hormone synthesis_Homo sapiens_hsa049180.51232127
82Pancreatic secretion_Homo sapiens_hsa049720.50016511
83Glutathione metabolism_Homo sapiens_hsa004800.47054712
84Insulin resistance_Homo sapiens_hsa049310.45836986
85Renin-angiotensin system_Homo sapiens_hsa046140.44983798
86Glutamatergic synapse_Homo sapiens_hsa047240.44275844
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.43601063
88Arachidonic acid metabolism_Homo sapiens_hsa005900.43391748
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42805054
90Complement and coagulation cascades_Homo sapiens_hsa046100.42553572
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42114948
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.41687931
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40813083
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40676910
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39707646
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39584204
97Huntingtons disease_Homo sapiens_hsa050160.39180343
98N-Glycan biosynthesis_Homo sapiens_hsa005100.39124981
99Inositol phosphate metabolism_Homo sapiens_hsa005620.38946163
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.38271703

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »