SCGB1C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)8.70372324
2protein neddylation (GO:0045116)8.67591175
3regulation of skeletal muscle contraction (GO:0014819)8.28461049
4uronic acid metabolic process (GO:0006063)7.49984109
5glucuronate metabolic process (GO:0019585)7.49984109
6neutrophil activation involved in immune response (GO:0002283)7.27194127
7cellular glucuronidation (GO:0052695)6.93795066
8glutathione derivative metabolic process (GO:1901685)6.89721345
9glutathione derivative biosynthetic process (GO:1901687)6.89721345
10negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)6.73522733
11one-carbon compound transport (GO:0019755)6.64761046
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.43436796
13benzene-containing compound metabolic process (GO:0042537)6.37566931
14regulation of platelet aggregation (GO:0090330)6.36519976
15blood coagulation, intrinsic pathway (GO:0007597)6.10399981
16regulation of platelet activation (GO:0010543)6.07230392
17relaxation of cardiac muscle (GO:0055119)5.99182130
18adenosine receptor signaling pathway (GO:0001973)5.75945501
19negative regulation of homotypic cell-cell adhesion (GO:0034111)5.64815427
20regulation of integrin-mediated signaling pathway (GO:2001044)5.63766316
21regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.55403688
22negative regulation of platelet activation (GO:0010544)5.47188896
23platelet aggregation (GO:0070527)5.44700234
24negative regulation of norepinephrine secretion (GO:0010700)5.37292020
25negative regulation of thymocyte apoptotic process (GO:0070244)5.35825042
26response to dietary excess (GO:0002021)5.30531101
27positive regulation of endothelial cell differentiation (GO:0045603)5.23408915
28leukocyte migration involved in inflammatory response (GO:0002523)5.22245975
29regulation of cardioblast proliferation (GO:0003264)5.19918156
30regulation of secondary heart field cardioblast proliferation (GO:0003266)5.19918156
31sensory perception of smell (GO:0007608)5.16913513
32negative regulation of heart rate (GO:0010459)5.12923982
33lipoxygenase pathway (GO:0019372)5.12603843
34low-density lipoprotein particle remodeling (GO:0034374)5.10380135
35negative regulation of macrophage derived foam cell differentiation (GO:0010745)5.09486813
36renal absorption (GO:0070293)5.07855988
37sulfate transmembrane transport (GO:1902358)4.96674964
38glutathione metabolic process (GO:0006749)4.90365744
39response to caffeine (GO:0031000)4.82994313
40negative regulation of fatty acid transport (GO:2000192)4.74455109
41nucleotide transmembrane transport (GO:1901679)4.71137783
42positive regulation of actin filament depolymerization (GO:0030836)4.49733168
43positive regulation of mast cell activation (GO:0033005)4.37566683
44negative regulation of protein localization to cell surface (GO:2000009)4.33842904
45G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.33186554
46platelet degranulation (GO:0002576)4.30625805
47angiogenesis involved in wound healing (GO:0060055)4.27996674
48neutrophil activation (GO:0042119)4.27325507
49fusion of sperm to egg plasma membrane (GO:0007342)4.25233302
50L-ascorbic acid metabolic process (GO:0019852)4.22016602
51mesenchyme morphogenesis (GO:0072132)4.17401074
52regulation of Golgi to plasma membrane protein transport (GO:0042996)4.15404434
53purinergic nucleotide receptor signaling pathway (GO:0035590)4.13710668
54regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.13368350
55relaxation of muscle (GO:0090075)4.09466880
56beta-amyloid metabolic process (GO:0050435)4.08404591
57androgen biosynthetic process (GO:0006702)4.07711275
58negative regulation of appetite (GO:0032099)4.07073744
59negative regulation of response to food (GO:0032096)4.07073744
60regulation of integrin activation (GO:0033623)4.06783543
61regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.06232424
62positive regulation of cAMP-mediated signaling (GO:0043950)4.05489385
63purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.05396308
643-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.05396308
65generation of neurons (GO:0048699)4.04906630
66regulation of lipoprotein metabolic process (GO:0050746)4.03473454
67sulfate transport (GO:0008272)4.02902175
68positive regulation of Rho protein signal transduction (GO:0035025)4.02056947
69pharyngeal system development (GO:0060037)3.98763236
70positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.89074745
71polyamine biosynthetic process (GO:0006596)3.88937973
72long-chain fatty acid biosynthetic process (GO:0042759)3.88061306
73regulation of homotypic cell-cell adhesion (GO:0034110)3.86707166
74positive regulation of systemic arterial blood pressure (GO:0003084)3.85293408
75positive regulation of macrophage differentiation (GO:0045651)3.85099421
76platelet activation (GO:0030168)3.84771774
77phenylpropanoid metabolic process (GO:0009698)3.83575216
78positive regulation of receptor recycling (GO:0001921)3.80374825
79endocardial cushion morphogenesis (GO:0003203)3.79618519
80regulation of macrophage derived foam cell differentiation (GO:0010743)3.78476341
81negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.76003404
82platelet formation (GO:0030220)3.75949320
83homotypic cell-cell adhesion (GO:0034109)3.74927324
84granulocyte activation (GO:0036230)3.74160322
85positive regulation of steroid biosynthetic process (GO:0010893)3.73460011
86sulfation (GO:0051923)3.73260922
87high-density lipoprotein particle remodeling (GO:0034375)3.72313013
88megakaryocyte development (GO:0035855)3.71340034
89phospholipid homeostasis (GO:0055091)3.69901629
90regulation of norepinephrine secretion (GO:0014061)3.68363155
91extracellular fibril organization (GO:0043206)3.68021592
92negative regulation of heart contraction (GO:0045822)3.65806501
93purinergic receptor signaling pathway (GO:0035587)3.60136012
94regulation of cholesterol biosynthetic process (GO:0045540)3.57520431
95regulation of cholesterol efflux (GO:0010874)3.52845796
96hormone catabolic process (GO:0042447)3.52609404
97reverse cholesterol transport (GO:0043691)3.52592560
98positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.52552228
99regulation of endothelial cell differentiation (GO:0045601)3.52310374
100positive regulation of blood coagulation (GO:0030194)3.49714527
101positive regulation of hemostasis (GO:1900048)3.49714527
102negative regulation of neural precursor cell proliferation (GO:2000178)3.47942954
103bicarbonate transport (GO:0015701)3.47048629
104negative regulation of cation channel activity (GO:2001258)3.46040026
105G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.45521113
106negative regulation of calcium ion transmembrane transport (GO:1903170)3.43789687
107negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.43789687
108mitochondrial calcium ion transport (GO:0006851)3.43118341
109prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.41891623
110regulation of MHC class II biosynthetic process (GO:0045346)3.38310129
111cell differentiation involved in metanephros development (GO:0072202)3.37824419
112negative regulation of catecholamine secretion (GO:0033604)3.36076306
113negative regulation of T cell apoptotic process (GO:0070233)3.35691277
114outer ear morphogenesis (GO:0042473)3.28369175
115termination of G-protein coupled receptor signaling pathway (GO:0038032)3.26497348
116regulation of female receptivity (GO:0045924)3.25506664
117autophagic vacuole fusion (GO:0000046)3.24339836
118negative regulation of chondrocyte differentiation (GO:0032331)3.23925558
119termination of signal transduction (GO:0023021)3.22734892
120surfactant homeostasis (GO:0043129)3.19469522
121response to food (GO:0032094)3.19047311
122polyol transport (GO:0015791)3.14566256
123negative regulation of JUN kinase activity (GO:0043508)3.14213838
124vesicle targeting (GO:0006903)3.13530223
125aorta morphogenesis (GO:0035909)3.12398438
126Notch signaling involved in heart development (GO:0061314)3.11296969
127positive regulation of coagulation (GO:0050820)3.09403955
128plasma membrane fusion (GO:0045026)3.08700479
129regulation of phospholipase A2 activity (GO:0032429)3.08630823
130thrombin receptor signaling pathway (GO:0070493)3.08601016
131regulation of receptor recycling (GO:0001919)3.08261130
132regulation of hemostasis (GO:1900046)3.05058393
133regulation of blood coagulation (GO:0030193)3.05058393
134fibril organization (GO:0097435)3.04241903
135negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.03933041
136spermatid nucleus differentiation (GO:0007289)3.03322229
137negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.01963624
138negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.01326986
139metanephric mesenchyme development (GO:0072075)3.00864707
140cyclooxygenase pathway (GO:0019371)2.99183453
141activation of MAPKKK activity (GO:0000185)2.96686912
142relaxation of smooth muscle (GO:0044557)2.92303428
143negative regulation of stress fiber assembly (GO:0051497)2.91388647
144negative regulation of T-helper cell differentiation (GO:0045623)2.91333337
145negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.91333337
146erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.91295568
147L-phenylalanine catabolic process (GO:0006559)2.91295568
148regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.90477816
149leukocyte degranulation (GO:0043299)2.88787551
150negative regulation of protein localization to plasma membrane (GO:1903077)2.88389007
151chemical homeostasis within a tissue (GO:0048875)2.87899178
152phagocytosis, engulfment (GO:0006911)2.87007879
153negative regulation of calcium ion transport into cytosol (GO:0010523)2.86469974
154negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.85677991
155negative regulation of axon extension involved in axon guidance (GO:0048843)2.85489441
156sequestering of actin monomers (GO:0042989)2.85486372
157endothelium development (GO:0003158)2.84936587
158positive regulation of T cell migration (GO:2000406)2.83903096
159sulfur compound transport (GO:0072348)2.83783443
160fat-soluble vitamin biosynthetic process (GO:0042362)2.83531690
161Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83060483
162positive regulation of mast cell activation involved in immune response (GO:0033008)2.82934565
163positive regulation of mast cell degranulation (GO:0043306)2.82934565
164pyrimidine nucleoside catabolic process (GO:0046135)2.82793878
165female mating behavior (GO:0060180)2.82464783
166negative regulation of osteoblast proliferation (GO:0033689)2.80944640
167cellular biogenic amine biosynthetic process (GO:0042401)2.80035807
168negative regulation of cell junction assembly (GO:1901889)2.79500397
169adenine nucleotide transport (GO:0051503)2.79455231
170positive regulation of catenin import into nucleus (GO:0035413)2.79064352
171regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.77389121
172xenobiotic metabolic process (GO:0006805)2.77310366
173regulation of cell proliferation involved in kidney development (GO:1901722)2.77082976
174purine ribonucleotide transport (GO:0015868)2.73596986
175prostaglandin metabolic process (GO:0006693)2.73456166
176prostanoid metabolic process (GO:0006692)2.73456166
177ureteric bud development (GO:0001657)2.72973008
178C21-steroid hormone biosynthetic process (GO:0006700)2.67848833
179positive regulation of gastrulation (GO:2000543)2.65603918
180toxin metabolic process (GO:0009404)2.65467634
181regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.60900511
182establishment of epithelial cell polarity (GO:0090162)2.60227383
183hyperosmotic salinity response (GO:0042538)2.59703075
184kidney mesenchyme development (GO:0072074)2.59009043
185regulation of glomerulus development (GO:0090192)2.58863615
186sensory perception of chemical stimulus (GO:0007606)2.57894087
187nucleotide transport (GO:0006862)2.56170932
188positive regulation of steroid metabolic process (GO:0045940)2.55131262
189branching involved in salivary gland morphogenesis (GO:0060445)2.53376323
190regulation of endothelial cell chemotaxis (GO:2001026)2.52767185
191cell proliferation involved in kidney development (GO:0072111)2.52488168
192positive regulation of cation channel activity (GO:2001259)2.51477419
193negative regulation of protein acetylation (GO:1901984)2.51448603
194purine nucleotide transport (GO:0015865)2.48909929
195regulation of podosome assembly (GO:0071801)2.48552777
196response to interferon-beta (GO:0035456)2.47344931
197response to nitrosative stress (GO:0051409)15.7818365
198xenobiotic catabolic process (GO:0042178)15.6168620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human5.16511348
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.44068725
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.99439258
4SCL_19346495_ChIP-Seq_HPC-7_Human3.94425552
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.50523369
6GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.21701358
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.18784644
8GATA1_19941826_ChIP-Seq_K562_Human3.07285450
9CLOCK_20551151_ChIP-Seq_293T_Human3.06193934
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.04412103
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.84889435
12LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.81046934
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.80938979
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.79927046
15EZH2_22144423_ChIP-Seq_EOC_Human2.77065775
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.69645291
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67444308
18GATA2_19941826_ChIP-Seq_K562_Human2.67242619
19SRY_22984422_ChIP-ChIP_TESTIS_Rat2.62956758
20GATA1_19941827_ChIP-Seq_MEL_Mouse2.55214540
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.50380186
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.45334703
23GATA2_21666600_ChIP-Seq_HMVEC_Human2.35097018
24GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.18637131
25SPI1_23127762_ChIP-Seq_K562_Human2.18068988
26HTT_18923047_ChIP-ChIP_STHdh_Human2.17211821
27TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.16402191
28GBX2_23144817_ChIP-Seq_PC3_Human2.11068879
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10278565
30ELK4_26923725_Chip-Seq_MESODERM_Mouse2.09668747
31GATA1_22383799_ChIP-Seq_G1ME_Mouse2.09460118
32IRF8_21731497_ChIP-ChIP_J774_Mouse2.08416959
33MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07336788
34RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06977301
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06551315
36ZNF217_24962896_ChIP-Seq_MCF-7_Human2.01876421
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96877698
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95029860
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93016713
40* TAF15_26573619_Chip-Seq_HEK293_Human1.92972230
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.89805295
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.86763384
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.86763384
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.86763384
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.84961662
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80051343
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79946369
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79066000
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75279511
50GATA1_22025678_ChIP-Seq_K562_Human1.74076842
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73531283
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65101989
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64068065
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64068065
55* RUNX1_22412390_ChIP-Seq_EML_Mouse1.63093531
56GATA1_19941827_ChIP-Seq_MEL86_Mouse1.62426443
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.62167865
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.60192577
59AHR_22903824_ChIP-Seq_MCF-7_Human1.59791255
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59446032
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59322744
62ZNF263_19887448_ChIP-Seq_K562_Human1.58993106
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56528252
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55456576
65DROSHA_22980978_ChIP-Seq_HELA_Human1.53658780
66AR_21572438_ChIP-Seq_LNCaP_Human1.51261726
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50522583
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50503790
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50503790
70KLF5_25053715_ChIP-Seq_YYC3_Human1.47332433
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46905538
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46788479
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.45910720
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.45811136
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44091616
76EED_16625203_ChIP-ChIP_MESCs_Mouse1.43839129
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.42397719
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41393818
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41133036
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40212302
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38419727
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37715004
83SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36359397
84NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36265224
85PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36027924
86SOX2_20726797_ChIP-Seq_SW620_Human1.35255738
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35156538
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34714552
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.33662974
90JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29643200
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29431293
92TP53_18474530_ChIP-ChIP_U2OS_Human1.26963571
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26244155
94TCF4_18268006_ChIP-ChIP_LS174T_Human1.24849197
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.24526832
96KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24099283
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.23850233
98LXR_22158963_ChIP-Seq_LIVER_Mouse1.23447233
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21462663
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21247557
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20707378
102SALL4_22934838_ChIP-ChIP_CD34+_Human1.19608469
103RUNX_20019798_ChIP-Seq_JUKART_Human1.19352607
104PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19082897
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18942594
106SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18891172
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17435894
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16887453
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16676121
110* CDX2_20551321_ChIP-Seq_CACO-2_Human1.16303878
111CJUN_26792858_Chip-Seq_BT549_Human1.15838243
112TP53_20018659_ChIP-ChIP_R1E_Mouse1.15247800
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.15049639
114VDR_24787735_ChIP-Seq_THP-1_Human1.12841710
115SPI1_20517297_ChIP-Seq_HL60_Human1.12841425
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12563742
117STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10585165
118ETS1_22383799_ChIP-Seq_G1ME_Mouse1.09392799
119ESR1_20079471_ChIP-ChIP_T-47D_Human1.07701353
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07571651
121BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06862688
122ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06134610
123SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05977486
124FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05200692
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.04887119
126PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04328818
127LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04278976
128MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04163570
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02178510
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01617671
131EZH2_27294783_Chip-Seq_ESCs_Mouse1.00025797
132NCOR1_26117541_ChIP-Seq_K562_Human0.99814310
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99038362
134SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98843389
135VDR_22108803_ChIP-Seq_LS180_Human0.98460525
136LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97998028
137RUNX1_27514584_Chip-Seq_MCF-7_Human0.97569087
138EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97292973
139EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96856052
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.96071682
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95748095
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95148588
143HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94741141
144RXR_22108803_ChIP-Seq_LS180_Human0.93953255
145STAT1_20625510_ChIP-Seq_HELA_Human0.93845484
146TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93591481
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93405498
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93226655
149CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93164240
150GATA4_25053715_ChIP-Seq_YYC3_Human0.92801058
151SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92360857
152JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92257830
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91998532
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91998532
155RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91024735
156RING1B_27294783_Chip-Seq_ESCs_Mouse0.90555201
157EZH2_27304074_Chip-Seq_ESCs_Mouse0.90469109
158GATA3_21878914_ChIP-Seq_MCF-7_Human0.90146176
159PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89685213
160TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88546187
161FOXO3_23340844_ChIP-Seq_DLD1_Human0.87942929
162NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87673348
163TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86328892
164SMAD4_21799915_ChIP-Seq_A2780_Human0.86053265
165VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84527868
166JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84527025
167ERG_20517297_ChIP-Seq_VCAP_Human0.82346385
168AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82190199
169BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81632357
170STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81362004
171OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80175694
172* OCT1_27270436_Chip-Seq_PROSTATE_Human0.79683640
173EZH2_27294783_Chip-Seq_NPCs_Mouse0.77984180
174PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77914364
175GF1_26923725_Chip-Seq_HPCs_Mouse0.77757298
176EWS_26573619_Chip-Seq_HEK293_Human0.77615849
177FLI1_27457419_Chip-Seq_LIVER_Mouse0.76620857
178* AR_25329375_ChIP-Seq_VCAP_Human0.75818262
179NANOG_19829295_ChIP-Seq_ESCs_Human0.75142587
180SOX2_19829295_ChIP-Seq_ESCs_Human0.75142587
181P53_22387025_ChIP-Seq_ESCs_Mouse0.74734048
182SMRT_27268052_Chip-Seq_Bcells_Human0.73000715
183RUNX1_26923725_Chip-Seq_HPCs_Mouse0.72975576
184SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.72482568
185CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70303152
186CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.69305771
187NANOG_20526341_ChIP-Seq_ESCs_Human0.68991677

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium6.19331850
2MP0010030_abnormal_orbit_morphology5.94944518
3MP0005499_abnormal_olfactory_system5.62274502
4MP0005394_taste/olfaction_phenotype5.62274502
5MP0008004_abnormal_stomach_pH5.48109242
6MP0008875_abnormal_xenobiotic_pharmacok5.42229508
7MP0002877_abnormal_melanocyte_morpholog4.20131597
8MP0001984_abnormal_olfaction3.60235580
9MP0001346_abnormal_lacrimal_gland3.23443855
10MP0006292_abnormal_olfactory_placode3.16229181
11MP0000678_abnormal_parathyroid_gland3.13534504
12MP0004043_abnormal_pH_regulation3.10042531
13MP0009379_abnormal_foot_pigmentation3.06723116
14MP0002254_reproductive_system_inflammat2.78598977
15MP0004510_myositis2.53090822
16MP0000343_altered_response_to2.46038749
17MP0003566_abnormal_cell_adhesion2.44980727
18MP0000762_abnormal_tongue_morphology2.41002090
19MP0002736_abnormal_nociception_after2.31828471
20MP0000230_abnormal_systemic_arterial2.30812443
21MP0003303_peritoneal_inflammation2.22902642
22MP0010368_abnormal_lymphatic_system2.20706077
23MP0002233_abnormal_nose_morphology2.17198909
24MP0001879_abnormal_lymphatic_vessel2.04516136
25MP0004084_abnormal_cardiac_muscle2.03878458
26MP0001835_abnormal_antigen_presentation2.03876639
27MP0002249_abnormal_larynx_morphology2.03374825
28MP0000049_abnormal_middle_ear2.02180367
29MP0005464_abnormal_platelet_physiology10.5217562
30MP0000534_abnormal_ureter_morphology1.96998934
31MP0005410_abnormal_fertilization1.92705705
32MP0003638_abnormal_response/metabolism_1.90184621
33MP0000566_synostosis1.81346812
34MP0005167_abnormal_blood-brain_barrier1.79088356
35MP0008775_abnormal_heart_ventricle1.77698924
36MP0003879_abnormal_hair_cell1.72783367
37MP0005058_abnormal_lysosome_morphology1.72767241
38MP0002234_abnormal_pharynx_morphology1.70843582
39MP0008872_abnormal_physiological_respon1.70288151
40MP0004130_abnormal_muscle_cell1.65576923
41MP0010155_abnormal_intestine_physiology1.58675795
42MP0005671_abnormal_response_to1.58640961
43MP0001851_eye_inflammation1.58412887
44MP0004147_increased_porphyrin_level1.57187260
45MP0005365_abnormal_bile_salt1.53076765
46MP0009053_abnormal_anal_canal1.51362245
47MP0001501_abnormal_sleep_pattern1.49983666
48MP0003186_abnormal_redox_activity1.49721699
49MP0002148_abnormal_hypersensitivity_rea1.49493033
50MP0004036_abnormal_muscle_relaxation1.46318837
51MP0002098_abnormal_vibrissa_morphology1.43251709
52MP0001968_abnormal_touch/_nociception1.41801627
53MP0002733_abnormal_thermal_nociception1.40877541
54MP0009250_abnormal_appendicular_skeleto1.36656638
55MP0001905_abnormal_dopamine_level1.35867210
56MP0001663_abnormal_digestive_system1.32967340
57MP0004947_skin_inflammation1.31167980
58MP0000613_abnormal_salivary_gland1.31090960
59MP0000249_abnormal_blood_vessel1.30088174
60MP0002398_abnormal_bone_marrow1.27120962
61MP0005000_abnormal_immune_tolerance1.26284635
62MP0001545_abnormal_hematopoietic_system1.22423862
63MP0005397_hematopoietic_system_phenotyp1.22423862
64MP0009763_increased_sensitivity_to1.18827588
65MP0004215_abnormal_myocardial_fiber1.17277228
66MP0009697_abnormal_copulation1.12468727
67MP0003942_abnormal_urinary_system1.10053517
68MP0003938_abnormal_ear_development1.09706206
69MP0003941_abnormal_skin_development1.08761306
70MP0008874_decreased_physiological_sensi1.08168245
71MP0003136_yellow_coat_color1.06684056
72MP0001270_distended_abdomen1.06346149
73MP0005501_abnormal_skin_physiology1.06036074
74MP0001533_abnormal_skeleton_physiology1.04859314
75MP0003937_abnormal_limbs/digits/tail_de1.03616645
76MP0000858_altered_metastatic_potential1.02387237
77MP0010329_abnormal_lipoprotein_level1.01718492
78MP0005409_darkened_coat_color0.99961264
79MP0009642_abnormal_blood_homeostasis0.98734014
80MP0002751_abnormal_autonomic_nervous0.96706649
81MP0001765_abnormal_ion_homeostasis0.95676527
82MP0002723_abnormal_immune_serum0.95147728
83MP0006276_abnormal_autonomic_nervous0.94962218
84MP0000015_abnormal_ear_pigmentation0.94631657
85MP0000681_abnormal_thyroid_gland0.94578503
86MP0001970_abnormal_pain_threshold0.94574025
87MP0005666_abnormal_adipose_tissue0.93840097
88MP0003866_abnormal_defecation0.93587743
89MP0000467_abnormal_esophagus_morphology0.93407425
90MP0005646_abnormal_pituitary_gland0.92299429
91MP0009780_abnormal_chondrocyte_physiolo0.92061578
92MP0009764_decreased_sensitivity_to0.91555763
93MP0009765_abnormal_xenobiotic_induced0.90789737
94MP0003690_abnormal_glial_cell0.90040059
95MP0002429_abnormal_blood_cell0.89233084
96MP0005085_abnormal_gallbladder_physiolo0.88538708
97MP0002277_abnormal_respiratory_mucosa0.88460166
98MP0000689_abnormal_spleen_morphology0.86987710
99MP0005165_increased_susceptibility_to0.86609697
100MP0003806_abnormal_nucleotide_metabolis0.86478841
101MP0003436_decreased_susceptibility_to0.86382813
102MP0002972_abnormal_cardiac_muscle0.86046728
103MP0005248_abnormal_Harderian_gland0.85826926
104MP0005381_digestive/alimentary_phenotyp0.85437243
105MP0005023_abnormal_wound_healing0.84380960
106MP0002452_abnormal_antigen_presenting0.82920421
107MP0001800_abnormal_humoral_immune0.82588453
108MP0006138_congestive_heart_failure0.82448939
109MP0003656_abnormal_erythrocyte_physiolo0.81944670
110MP0005408_hypopigmentation0.81842399
111MP0001544_abnormal_cardiovascular_syste0.80939392
112MP0005385_cardiovascular_system_phenoty0.80939392
113MP0004019_abnormal_vitamin_homeostasis0.79772788
114MP0003724_increased_susceptibility_to0.79646026
115MP0004883_abnormal_blood_vessel0.78368021
116MP0003453_abnormal_keratinocyte_physiol0.78092005
117MP0003890_abnormal_embryonic-extraembry0.77893500
118MP0001664_abnormal_digestion0.77119834
119MP0002722_abnormal_immune_system0.76657700
120MP0005084_abnormal_gallbladder_morpholo0.75661683
121MP0009333_abnormal_splenocyte_physiolog0.75622105
122MP0001177_atelectasis0.75124418
123MP0001845_abnormal_inflammatory_respons0.74677144
124MP0002998_abnormal_bone_remodeling0.74590203
125MP0004264_abnormal_extraembryonic_tissu0.73614829
126MP0002060_abnormal_skin_morphology0.73448394
127MP0003755_abnormal_palate_morphology0.72937317
128MP0006054_spinal_hemorrhage0.72760030
129MP0000383_abnormal_hair_follicle0.72736986
130MP0002128_abnormal_blood_circulation0.72402059
131MP0002697_abnormal_eye_size0.72000563
132MP0008995_early_reproductive_senescence0.70413790
133MP0002177_abnormal_outer_ear0.70411229
134MP0002420_abnormal_adaptive_immunity0.70377600
135MP0002735_abnormal_chemical_nociception0.70270626
136MP0009840_abnormal_foam_cell0.69279905
137MP0001819_abnormal_immune_cell0.69068939
138MP0005174_abnormal_tail_pigmentation0.68461165
139MP0000716_abnormal_immune_system0.68379592
140MP0002118_abnormal_lipid_homeostasis0.67881690
141MP0000358_abnormal_cell_content/0.67238598
142MP0000631_abnormal_neuroendocrine_gland0.66752164
143MP0002132_abnormal_respiratory_system0.66746012
144MP0002090_abnormal_vision0.66621848
145MP0005535_abnormal_body_temperature0.66510553
146MP0005620_abnormal_muscle_contractility0.66490126
147MP0003279_aneurysm0.66067488
148MP0006036_abnormal_mitochondrial_physio0.66065197
149MP0005197_abnormal_uvea_morphology0.65940682
150MP0003828_pulmonary_edema0.65494118
151MP0003011_delayed_dark_adaptation0.65351471
152MP0001188_hyperpigmentation0.65133617
153MP0005171_absent_coat_pigmentation0.65027423
154MP0005187_abnormal_penis_morphology0.64594976
155MP0002938_white_spotting0.64566390
156MP0004484_altered_response_of0.63094374
157MP0005164_abnormal_response_to0.63031301
158MP0000685_abnormal_immune_system0.63022045
159MP0002876_abnormal_thyroid_physiology0.62809955
160MP0000428_abnormal_craniofacial_morphol0.62780221
161MP0004134_abnormal_chest_morphology0.62663185
162MP0010678_abnormal_skin_adnexa0.61945312
163MP0001849_ear_inflammation0.60867893
164MP0002295_abnormal_pulmonary_circulatio0.60425438
165MP0002133_abnormal_respiratory_system0.59761744
166MP0005388_respiratory_system_phenotype0.59761744
167MP0000372_irregular_coat_pigmentation0.58947832
168MP0001340_abnormal_eyelid_morphology0.58670859
169MP0003786_premature_aging0.58430503
170MP0000579_abnormal_nail_morphology0.57280384
171MP0000465_gastrointestinal_hemorrhage0.56233587
172MP0003075_altered_response_to0.55609482
173MP0000537_abnormal_urethra_morphology0.53762555
174MP0000163_abnormal_cartilage_morphology0.53314071
175MP0001485_abnormal_pinna_reflex0.52608588
176MP0003385_abnormal_body_wall0.52150284
177MP0002557_abnormal_social/conspecific_i0.50963837
178MP0005083_abnormal_biliary_tract0.49522960
179MP0001502_abnormal_circadian_rhythm0.49279314
180MP0001756_abnormal_urination0.48071604
181MP0004782_abnormal_surfactant_physiolog0.47218021
182MP0009278_abnormal_bone_marrow0.47121550
183MP0009672_abnormal_birth_weight0.45043624

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)9.73884268
2Purpura (HP:0000979)9.13571075
3Epistaxis (HP:0000421)7.80050905
4Hyperlipoproteinemia (HP:0010980)7.17439904
5Gingival bleeding (HP:0000225)6.52675693
6Lip pit (HP:0100267)6.40929976
7Stomach cancer (HP:0012126)5.73267381
8Abnormal platelet function (HP:0011869)5.57569362
9Impaired platelet aggregation (HP:0003540)5.57569362
10Bifid scrotum (HP:0000048)5.36992143
11Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.89734433
12Dyschromatopsia (HP:0007641)4.87764881
13Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)4.77381419
14Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)4.43930718
15Acanthocytosis (HP:0001927)4.41278556
16Abnormality of the phalanges of the 2nd finger (HP:0009541)4.32121925
17Poikilocytosis (HP:0004447)4.29276138
18Abnormality of the middle phalanges of the toes (HP:0010183)4.19698006
19Spontaneous hematomas (HP:0007420)4.02473740
20Abnormality of the middle phalanx of the 5th finger (HP:0004219)4.02467030
21Conjunctival telangiectasia (HP:0000524)3.79845385
22Abnormal pupillary function (HP:0007686)3.71401144
23Abnormality of the phalanges of the 5th finger (HP:0004213)3.69440089
24Synostosis involving the elbow (HP:0003938)3.65487401
25Humeroradial synostosis (HP:0003041)3.65487401
26Stenosis of the external auditory canal (HP:0000402)3.61198117
27Down-sloping shoulders (HP:0200021)3.59652348
28Abnormality of the common coagulation pathway (HP:0010990)3.51042061
29Short middle phalanx of the 5th finger (HP:0004220)3.45171706
30Bruising susceptibility (HP:0000978)3.38946805
31Abnormality of the distal phalanges of the toes (HP:0010182)3.38506834
32Paralysis (HP:0003470)3.36047152
33Hyperventilation (HP:0002883)3.33313238
34Split foot (HP:0001839)3.30083183
35Alveolar cell carcinoma (HP:0006519)3.28414707
36Abnormality of the vasculature of the conjunctiva (HP:0008054)3.27993807
37Aplasia involving bones of the extremities (HP:0009825)3.18427930
38Aplasia involving bones of the upper limbs (HP:0009823)3.18427930
39Aplasia of the phalanges of the hand (HP:0009802)3.18427930
40Abnormal hemoglobin (HP:0011902)3.18311477
41Abnormality of the heme biosynthetic pathway (HP:0010472)3.17998185
42Distal lower limb muscle weakness (HP:0009053)3.05154800
43Neoplasm of the tracheobronchial system (HP:0100552)3.04788524
44Bronchomalacia (HP:0002780)3.03100335
45Abnormality of lateral ventricle (HP:0030047)3.03065936
46Cheilitis (HP:0100825)2.99077428
47Short hallux (HP:0010109)2.89390345
48Abnormal auditory evoked potentials (HP:0006958)2.88421347
49Hepatoblastoma (HP:0002884)2.87699319
50Decreased central vision (HP:0007663)2.84643503
51Fibular aplasia (HP:0002990)2.83818730
52Morphological abnormality of the middle ear (HP:0008609)2.78655252
53Xanthomatosis (HP:0000991)2.76371138
54Renal tubular acidosis (HP:0001947)2.74824157
55Aplasia/Hypoplasia of the hallux (HP:0008362)2.73924347
56Upper limb muscle weakness (HP:0003484)2.73295610
57Abnormality of the 2nd finger (HP:0004100)2.71477707
58Short middle phalanx of finger (HP:0005819)2.71343855
59Urethral obstruction (HP:0000796)2.71251765
60Bowing of the arm (HP:0006488)2.68915389
61Bowed forearm bones (HP:0003956)2.68915389
62Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.65163506
63Periauricular skin pits (HP:0100277)2.62372482
64Preauricular pit (HP:0004467)2.62372482
65Increased density of long bones (HP:0006392)2.62050722
66Joint swelling (HP:0001386)2.59211302
67Hepatosplenomegaly (HP:0001433)2.54207734
68Mesomelia (HP:0003027)2.51623230
69Growth hormone excess (HP:0000845)2.49638407
70Abnormal pancreas size (HP:0012094)2.45612460
71Neoplasm of the adrenal cortex (HP:0100641)2.45350576
72Papillary thyroid carcinoma (HP:0002895)2.45030979
73Joint hemorrhage (HP:0005261)2.43870797
74Male infertility (HP:0003251)2.41351933
75Flat acetabular roof (HP:0003180)2.40012144
76Increased IgM level (HP:0003496)2.39662477
77Plantar hyperkeratosis (HP:0007556)2.38692255
78Sex reversal (HP:0012245)2.37688661
79Abnormal sex determination (HP:0012244)2.37688661
80Short nail (HP:0001799)2.37248349
81Ulnar bowing (HP:0003031)2.36997895
82Narrow nasal bridge (HP:0000446)2.36174208
83Generalized aminoaciduria (HP:0002909)2.35058521
84Eczematoid dermatitis (HP:0000976)2.34085871
85Popliteal pterygium (HP:0009756)2.33216821
86Septo-optic dysplasia (HP:0100842)2.30986456
87Cupped ear (HP:0000378)2.27011971
88Stomatitis (HP:0010280)2.26599890
89Tinnitus (HP:0000360)2.25876956
90Long clavicles (HP:0000890)2.23169835
91Abnormality of cochlea (HP:0000375)2.22890755
92Long foot (HP:0001833)2.21169452
93Hypoplastic labia majora (HP:0000059)2.21161913
94Nausea (HP:0002018)2.18798774
95Hydroureter (HP:0000072)2.17802366
96Ventricular fibrillation (HP:0001663)2.17752320
97Scapular winging (HP:0003691)2.17655051
98Sleep apnea (HP:0010535)2.17533555
99Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.17378093
100Short 1st metacarpal (HP:0010034)2.17378093
101Abnormality of macrophages (HP:0004311)2.16923769
102Thyroid-stimulating hormone excess (HP:0002925)2.15938927
103Spontaneous abortion (HP:0005268)2.13833152
104Submucous cleft hard palate (HP:0000176)2.12509614
105Palmar hyperkeratosis (HP:0010765)2.12290867
106Abnormality of iron homeostasis (HP:0011031)2.09548764
107Abnormality of the renal collecting system (HP:0004742)2.09476250
108Abnormality of the proximal phalanges of the hand (HP:0009834)2.08988005
109Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.08277038
110Skin pits (HP:0100276)2.08142226
111Abnormality of the middle phalanges of the hand (HP:0009833)2.07454710
112Hypoplastic scapulae (HP:0000882)2.04434799
113Aplasia/Hypoplasia of the scapulae (HP:0006713)2.04434799
114Nasolacrimal duct obstruction (HP:0000579)2.04098322
115Abnormal ciliary motility (HP:0012262)2.02661509
116Median cleft lip (HP:0000161)2.02526610
117Palmoplantar hyperkeratosis (HP:0000972)2.01859426
118Absent toe (HP:0010760)2.00476959
119Prolonged bleeding time (HP:0003010)11.9016054
120Menorrhagia (HP:0000132)11.1328114
121Increased mean platelet volume (HP:0011877)10.8055370
122Abnormal platelet volume (HP:0011876)10.1145974
123Advanced eruption of teeth (HP:0006288)1.98826280
124Femoral bowing (HP:0002980)1.97736741
125Degeneration of the lateral corticospinal tracts (HP:0002314)1.97082350
126Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97082350
127Right ventricular cardiomyopathy (HP:0011663)1.96651040
128Abnormality of the labia majora (HP:0012881)1.95289493
129Tongue fasciculations (HP:0001308)1.94569942
130Abnormal glucose tolerance (HP:0001952)1.94466412
131Adactyly (HP:0009776)1.92781344
132Dysautonomia (HP:0002459)1.92605161
133Bifid uvula (HP:0000193)1.91851766
134Fragile nails (HP:0001808)1.91505951
135Mixed hearing impairment (HP:0000410)1.91159874
136Distal lower limb amyotrophy (HP:0008944)1.90515237
137Hypophosphatemic rickets (HP:0004912)1.90271982
138Male pseudohermaphroditism (HP:0000037)1.89271504
139Cutaneous syndactyly (HP:0012725)1.88983841
140Pulmonary artery stenosis (HP:0004415)1.86490848
141Abnormality of the 1st metacarpal (HP:0010009)1.86483128
142Broad-based gait (HP:0002136)1.86265879
143Hallux valgus (HP:0001822)1.86244604
144Hyperthyroidism (HP:0000836)1.85992024
145Abnormality of transition element cation homeostasis (HP:0011030)1.84438831
146Absent eyebrow (HP:0002223)1.84099194
147Ridged nail (HP:0001807)1.83658952
148Cutaneous finger syndactyly (HP:0010554)1.82692279
149Milia (HP:0001056)1.81378786
150Biliary tract neoplasm (HP:0100574)1.80329305
151Deviation of the hallux (HP:0010051)1.79874256
152Osteolytic defects of the hand bones (HP:0009699)1.79671914
1533-Methylglutaconic aciduria (HP:0003535)1.76078781
154Muscle fibrillation (HP:0010546)1.75880719
155Arterial thrombosis (HP:0004420)1.70556610
156Myocardial infarction (HP:0001658)1.70205690
157Episodic fever (HP:0001954)1.66288787
158Thyroid carcinoma (HP:0002890)1.64956350
159Abnormal respiratory epithelium morphology (HP:0012253)1.64794658
160Abnormal respiratory motile cilium morphology (HP:0005938)1.64794658
161Increased serum ferritin (HP:0003281)1.64391532
162Encephalitis (HP:0002383)1.62459669
163Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.60138413
164Polycythemia (HP:0001901)1.57996209
165Infertility (HP:0000789)1.57871016
166Leiomyosarcoma (HP:0100243)1.56960939
167Uterine leiomyosarcoma (HP:0002891)1.56960939
168Polyphagia (HP:0002591)1.55764702
169Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.54736889
170Basal ganglia calcification (HP:0002135)1.54435118
171Arthropathy (HP:0003040)1.53645043
172Transitional cell carcinoma of the bladder (HP:0006740)1.52070846
173Vertigo (HP:0002321)1.51884551
174Lower limb amyotrophy (HP:0007210)1.50164812
175Testicular neoplasm (HP:0010788)1.49832372
176Renal Fanconi syndrome (HP:0001994)1.49768046
177Chronic obstructive pulmonary disease (HP:0006510)1.49323442
178Obstructive lung disease (HP:0006536)1.49323442
179Abnormality of the prostate (HP:0008775)1.49299952
180Autoimmune hemolytic anemia (HP:0001890)1.47270757
181Termporal pattern (HP:0011008)1.45655541
182Insidious onset (HP:0003587)1.45655541
183Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.41728260
184Mitral stenosis (HP:0001718)1.38392235
185Bladder carcinoma (HP:0002862)1.35655046
186Bladder neoplasm (HP:0009725)1.35655046
187Back pain (HP:0003418)1.35538003
188Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.34954217
189Abnormality of alanine metabolism (HP:0010916)1.34954217
190Hyperalaninemia (HP:0003348)1.34954217
191Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.33864207
192Absent/shortened dynein arms (HP:0200106)1.33113429
193Dynein arm defect of respiratory motile cilia (HP:0012255)1.33113429
194Abnormality of the Achilles tendon (HP:0005109)1.30125639
195Mucosal telangiectasiae (HP:0100579)1.29667626
196Abnormal respiratory motile cilium physiology (HP:0012261)1.28705888
197Abnormal spermatogenesis (HP:0008669)1.28248983
198Central scotoma (HP:0000603)1.27616387
199Ileus (HP:0002595)1.27375361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.98637420
2RIPK14.49704562
3MAP3K23.66405804
4MAP3K33.45821215
5EIF2AK13.15676819
6TEC2.96565567
7ZAK2.93901516
8BTK2.91792142
9HIPK22.86439538
10PTK2B2.81910924
11MAP2K22.79120829
12MKNK22.72306814
13MAPK152.58379587
14GRK52.27105753
15TAOK32.26769710
16SGK22.26624307
17EPHB22.21438762
18CSF1R2.17061442
19STK38L2.16256794
20MAPKAPK52.09225150
21SYK2.05682601
22PIK3CG1.99800177
23ZAP701.96149986
24PAK31.87664798
25SGK2231.76860293
26SGK4941.76860293
27GRK61.75936625
28STK31.70796354
29RPS6KA41.58850762
30DYRK31.56636867
31MST41.56524728
32BMPR21.55891511
33MAP3K121.55320369
34SGK31.54926410
35INSRR1.50989665
36MAP3K141.50778694
37PDK21.49639008
38TESK11.49242303
39EPHB11.48121833
40PLK21.40931286
41RPS6KB21.40222833
42WNK11.35043653
43DAPK31.34159977
44PNCK1.33213646
45PAK11.31779294
46ADRBK21.30967710
47HCK1.30610675
48FGFR21.29623159
49RPS6KA21.29038277
50NLK1.25941137
51MKNK11.25687821
52CAMK2B1.20868390
53PBK1.19234046
54CAMK2D1.18891390
55ACVR1B1.15478493
56NEK61.13194582
57STK241.09997737
58DMPK1.09433209
59MAPK71.08763170
60MYLK1.07079515
61PIM21.05946411
62TLK11.04736021
63PRKG21.03428123
64LYN1.02943819
65RPS6KL11.02937443
66RPS6KC11.02937443
67CAMK41.02089468
68BLK0.99176704
69TNK20.98250095
70FES0.96221605
71MAP2K10.94449678
72SIK10.93723424
73RPS6KA60.93690911
74MATK0.93479348
75GSK3A0.93003450
76CAMK2G0.90594378
77FRK0.90017405
78BMPR1B0.89334801
79ILK0.87965363
80DAPK20.87964471
81RET0.86266574
82TRIM280.86142129
83MAP3K50.84594859
84ADRBK10.83915113
85BCKDK0.83525893
86ERBB30.82680970
87ITK0.81926232
88PKN10.78401835
89EPHA20.77909748
90FER0.73786528
91PRPF4B0.72715386
92MARK30.71462086
93ALK0.69293904
94TESK20.69201113
95TXK0.68940803
96TAOK20.67460160
97MINK10.66218733
98ROCK20.65006084
99SIK30.63440612
100ROCK10.62371545
101ERBB40.62152013
102IKBKE0.61651581
103PDGFRB0.60323880
104ERBB20.60222657
105DAPK10.59757846
106TAOK10.59706802
107MARK20.59481882
108ARAF0.58865932
109MAPKAPK20.56157512
110CSK0.56080490
111MAPKAPK30.54213238
112OXSR10.54062571
113STK380.54048287
114TNIK0.53135910
115PRKACG0.52836010
116STK40.50077606
117LMTK20.50045218
118PDK10.49799713
119IKBKB0.48343908
120RPS6KA10.47725769
121CDK60.46280105
122LIMK10.45870436
123MAP4K20.45565295
124MAP2K30.44783165
125FGR0.44605932
126DYRK1A0.44445964
127PRKCE0.44273630
128PRKD10.43472567
129CSNK1G10.43371407
130EPHA30.43339392
131IRAK40.43326930
132MAPK40.43107371
133PRKG10.41314000
134FYN0.39629439
135CSNK1A10.39236792
136MAPK130.38267103
137GRK10.37869716
138ATR0.37394232
139SGK10.37352918
140CAMK2A0.36727341
141PDPK10.35841701
142AKT20.35267488
143STK100.34728770
144BMX0.34574386
145TYK20.34465487
146LCK0.34089557
147NUAK10.33994642
148TTN0.33127857
149PRKCD0.32552965
150PTK60.32012573
151IRAK10.31808928
152CSNK1D0.31247287
153YES10.30018991
154PRKCB0.29124543
155MAPK120.29043105
156CDK140.28953555
157IRAK20.27979250
158PRKCA0.27624169
159IRAK30.27554406
160JAK20.27068562
161JAK10.26616138
162SRC0.26020538
163CLK10.25835369
164IGF1R0.24763190
165PRKCQ0.21609937
166CDK80.20613578
167PAK20.20390595
168PIM10.19713445

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009826.02153123
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.86645679
3Platelet activation_Homo sapiens_hsa046115.73167148
4Chemical carcinogenesis_Homo sapiens_hsa052045.08707587
5Pentose and glucuronate interconversions_Homo sapiens_hsa000404.65633040
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.44385845
7Glutathione metabolism_Homo sapiens_hsa004804.35416578
8Steroid hormone biosynthesis_Homo sapiens_hsa001404.08625625
9ECM-receptor interaction_Homo sapiens_hsa045122.54296208
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.48781128
11Sulfur metabolism_Homo sapiens_hsa009202.48158842
12Hematopoietic cell lineage_Homo sapiens_hsa046402.26690442
13Nitrogen metabolism_Homo sapiens_hsa009102.17222593
14Serotonergic synapse_Homo sapiens_hsa047261.87391883
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.85360749
16Chemokine signaling pathway_Homo sapiens_hsa040621.82916612
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.80847339
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.75150017
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.71094920
20Butanoate metabolism_Homo sapiens_hsa006501.65280885
21Retinol metabolism_Homo sapiens_hsa008301.65246863
22Alcoholism_Homo sapiens_hsa050341.59670409
23Circadian rhythm_Homo sapiens_hsa047101.58838555
24Sulfur relay system_Homo sapiens_hsa041221.57544490
25Starch and sucrose metabolism_Homo sapiens_hsa005001.51031872
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48840199
27Systemic lupus erythematosus_Homo sapiens_hsa053221.45738115
28Endocytosis_Homo sapiens_hsa041441.40502515
29Rheumatoid arthritis_Homo sapiens_hsa053231.37481124
30Shigellosis_Homo sapiens_hsa051311.35710012
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26929716
32Regulation of actin cytoskeleton_Homo sapiens_hsa048101.24551425
33Caffeine metabolism_Homo sapiens_hsa002321.23836259
34Fatty acid elongation_Homo sapiens_hsa000621.15109762
35beta-Alanine metabolism_Homo sapiens_hsa004101.12129562
36Phospholipase D signaling pathway_Homo sapiens_hsa040721.11682217
37TNF signaling pathway_Homo sapiens_hsa046681.11577367
38Linoleic acid metabolism_Homo sapiens_hsa005911.10420060
39B cell receptor signaling pathway_Homo sapiens_hsa046621.08712109
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07630125
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.03834075
42Gastric acid secretion_Homo sapiens_hsa049711.00282284
43Long-term depression_Homo sapiens_hsa047300.99404943
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94418529
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.93244714
46Prostate cancer_Homo sapiens_hsa052150.92859066
47Olfactory transduction_Homo sapiens_hsa047400.92006571
48Focal adhesion_Homo sapiens_hsa045100.91623111
49Morphine addiction_Homo sapiens_hsa050320.91049752
50African trypanosomiasis_Homo sapiens_hsa051430.90259946
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89390033
52T cell receptor signaling pathway_Homo sapiens_hsa046600.86523327
53Rap1 signaling pathway_Homo sapiens_hsa040150.84280261
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83582669
55Choline metabolism in cancer_Homo sapiens_hsa052310.75769214
56Fat digestion and absorption_Homo sapiens_hsa049750.74495302
57Mismatch repair_Homo sapiens_hsa034300.73011966
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71528557
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70972593
60Collecting duct acid secretion_Homo sapiens_hsa049660.70658162
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69807984
62Ras signaling pathway_Homo sapiens_hsa040140.68874516
63Renin-angiotensin system_Homo sapiens_hsa046140.68186289
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67631019
65Phenylalanine metabolism_Homo sapiens_hsa003600.67313822
66GABAergic synapse_Homo sapiens_hsa047270.66849786
67Malaria_Homo sapiens_hsa051440.66108218
68Calcium signaling pathway_Homo sapiens_hsa040200.65068365
69Primary immunodeficiency_Homo sapiens_hsa053400.64192661
70ABC transporters_Homo sapiens_hsa020100.63968537
71Endometrial cancer_Homo sapiens_hsa052130.63088676
72Thyroid hormone synthesis_Homo sapiens_hsa049180.62954663
73Pancreatic cancer_Homo sapiens_hsa052120.61161800
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.60794831
75Histidine metabolism_Homo sapiens_hsa003400.60382554
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60333941
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.58908453
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56301624
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55980021
80Melanoma_Homo sapiens_hsa052180.55398712
81Viral carcinogenesis_Homo sapiens_hsa052030.54018224
82Bile secretion_Homo sapiens_hsa049760.53494871
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51107456
84Dilated cardiomyopathy_Homo sapiens_hsa054140.51088893
85Phototransduction_Homo sapiens_hsa047440.50613097
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50370995
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49976184
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48604873
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48403069
90Synaptic vesicle cycle_Homo sapiens_hsa047210.47967199
91Galactose metabolism_Homo sapiens_hsa000520.47375819
92Non-small cell lung cancer_Homo sapiens_hsa052230.47272264
93Glioma_Homo sapiens_hsa052140.46208155
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46031429
95Axon guidance_Homo sapiens_hsa043600.45459317
96Insulin resistance_Homo sapiens_hsa049310.45407685
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45269851
98Small cell lung cancer_Homo sapiens_hsa052220.43176378
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43134231
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43101138
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41952047
102Sphingolipid metabolism_Homo sapiens_hsa006000.41928283
103Thyroid cancer_Homo sapiens_hsa052160.41274498
104Adherens junction_Homo sapiens_hsa045200.39945016
105Glutamatergic synapse_Homo sapiens_hsa047240.39520047
106Salmonella infection_Homo sapiens_hsa051320.38899942
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38447644
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38285358
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38002361
110Prolactin signaling pathway_Homo sapiens_hsa049170.36954077
111Cocaine addiction_Homo sapiens_hsa050300.36940219
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35813239
113Amphetamine addiction_Homo sapiens_hsa050310.34970225
114Vibrio cholerae infection_Homo sapiens_hsa051100.34673220
115Arachidonic acid metabolism_Homo sapiens_hsa005900.34662445
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34497570
117Staphylococcus aureus infection_Homo sapiens_hsa051500.34227721
118Apoptosis_Homo sapiens_hsa042100.33833568
119Oxytocin signaling pathway_Homo sapiens_hsa049210.33292631
120Circadian entrainment_Homo sapiens_hsa047130.33092916
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33057343
122Mineral absorption_Homo sapiens_hsa049780.33042543
123Amoebiasis_Homo sapiens_hsa051460.31801768
124Hippo signaling pathway_Homo sapiens_hsa043900.31255172
125Cholinergic synapse_Homo sapiens_hsa047250.30506111
126Fatty acid degradation_Homo sapiens_hsa000710.30430507
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29908687
128Estrogen signaling pathway_Homo sapiens_hsa049150.29543338
129Tryptophan metabolism_Homo sapiens_hsa003800.28758792
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28404380
131Prion diseases_Homo sapiens_hsa050200.27717675
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27201570
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27035448
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.25996310
135Renin secretion_Homo sapiens_hsa049240.25398062
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24815377
137Peroxisome_Homo sapiens_hsa041460.24405811
138FoxO signaling pathway_Homo sapiens_hsa040680.24194794
139TGF-beta signaling pathway_Homo sapiens_hsa043500.23968733
140Phagosome_Homo sapiens_hsa041450.23378527
141Toxoplasmosis_Homo sapiens_hsa051450.23011541
142Chronic myeloid leukemia_Homo sapiens_hsa052200.22313515
143Osteoclast differentiation_Homo sapiens_hsa043800.22088745
144Pertussis_Homo sapiens_hsa051330.22005890
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21727018
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.21679765
147Tight junction_Homo sapiens_hsa045300.21432124
148PPAR signaling pathway_Homo sapiens_hsa033200.21009670
149Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.20836257
150Leishmaniasis_Homo sapiens_hsa051400.20656064
151Insulin secretion_Homo sapiens_hsa049110.20508550
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17615190
153Propanoate metabolism_Homo sapiens_hsa006400.17067922
154cAMP signaling pathway_Homo sapiens_hsa040240.16714227
155Gap junction_Homo sapiens_hsa045400.16382642
156Glycerolipid metabolism_Homo sapiens_hsa005610.16288354
157Pancreatic secretion_Homo sapiens_hsa049720.15528116
158Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15052230
159Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14986579
160Glycosaminoglycan degradation_Homo sapiens_hsa005310.13632768
161Salivary secretion_Homo sapiens_hsa049700.13294533
162SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13196804
163Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13034476
164Graft-versus-host disease_Homo sapiens_hsa053320.12622595
165Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.12537036
166Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.11963373

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