SCG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular ketone body metabolic process (GO:0046950)4.73688743
2glycerophospholipid catabolic process (GO:0046475)4.60827012
3detection of calcium ion (GO:0005513)4.55573274
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.39257065
5synaptic vesicle exocytosis (GO:0016079)4.35295416
6neuron cell-cell adhesion (GO:0007158)4.33552536
7inositol phosphate catabolic process (GO:0071545)4.32655808
8ketone body metabolic process (GO:1902224)4.17918506
9epithelial cell fate commitment (GO:0072148)4.13155024
10negative regulation of execution phase of apoptosis (GO:1900118)4.05632559
11inositol phosphate dephosphorylation (GO:0046855)4.04737881
12phosphorylated carbohydrate dephosphorylation (GO:0046838)4.04737881
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.04072473
14positive regulation of insulin secretion (GO:0032024)4.03168225
15protein maturation by protein folding (GO:0022417)4.02124134
16regulation of hexokinase activity (GO:1903299)4.01850122
17regulation of glucokinase activity (GO:0033131)4.01850122
18regulation of synaptic vesicle exocytosis (GO:2000300)4.01028508
19L-alpha-amino acid transmembrane transport (GO:1902475)3.98526079
20neuronal action potential propagation (GO:0019227)3.94927957
21vocalization behavior (GO:0071625)3.92897760
22positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.88206249
23presynaptic membrane assembly (GO:0097105)3.83029150
24lactate metabolic process (GO:0006089)3.82555902
25negative regulation of cytosolic calcium ion concentration (GO:0051481)3.79270789
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.77226010
27positive regulation of glycolytic process (GO:0045821)3.66107773
28water-soluble vitamin biosynthetic process (GO:0042364)3.65549478
29ATP hydrolysis coupled proton transport (GO:0015991)3.64766021
30energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.64766021
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.60703126
32positive regulation of peptide hormone secretion (GO:0090277)3.57850514
33Golgi transport vesicle coating (GO:0048200)3.55121907
34COPI coating of Golgi vesicle (GO:0048205)3.55121907
35signal peptide processing (GO:0006465)3.54307844
36regulation of synaptic vesicle transport (GO:1902803)3.52835802
37respiratory chain complex IV assembly (GO:0008535)3.51257347
38presynaptic membrane organization (GO:0097090)3.49704846
39protein localization to synapse (GO:0035418)3.48492256
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.48472407
41positive regulation of peptide secretion (GO:0002793)3.45861640
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43792522
43regulation of glutamate receptor signaling pathway (GO:1900449)3.43331573
44nitric oxide mediated signal transduction (GO:0007263)3.42300112
45auditory receptor cell differentiation (GO:0042491)3.41769473
46polyol catabolic process (GO:0046174)3.41169039
47glandular epithelial cell differentiation (GO:0002067)3.40274444
48glutamate secretion (GO:0014047)3.37016069
49positive regulation of gluconeogenesis (GO:0045722)3.35692517
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.35106869
51insulin secretion (GO:0030073)3.33816904
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32575525
53neuron-neuron synaptic transmission (GO:0007270)3.31158821
54neurotransmitter secretion (GO:0007269)3.30366663
55regulation of vesicle fusion (GO:0031338)3.29662140
56dopamine biosynthetic process (GO:0042416)3.27758489
57cytochrome complex assembly (GO:0017004)3.25046183
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.24616575
59negative regulation of hormone biosynthetic process (GO:0032353)3.24380490
60transferrin transport (GO:0033572)3.21804514
61macroautophagy (GO:0016236)3.21033268
62nitric oxide biosynthetic process (GO:0006809)3.20036240
63peptide hormone secretion (GO:0030072)3.19367074
64ionotropic glutamate receptor signaling pathway (GO:0035235)3.17305176
65ATP synthesis coupled proton transport (GO:0015986)3.15614235
66energy coupled proton transport, down electrochemical gradient (GO:0015985)3.15614235
67neuron recognition (GO:0008038)3.12161491
68glutamate receptor signaling pathway (GO:0007215)3.11084051
69regulation of dopamine metabolic process (GO:0042053)3.11029916
70regulation of catecholamine metabolic process (GO:0042069)3.11029916
71positive regulation of macroautophagy (GO:0016239)3.09865288
72postsynaptic membrane organization (GO:0001941)3.09849867
73peptide secretion (GO:0002790)3.08404487
74synaptic transmission, glutamatergic (GO:0035249)3.02227114
75long-term synaptic potentiation (GO:0060291)3.02065212
76trivalent inorganic cation transport (GO:0072512)3.01651432
77ferric iron transport (GO:0015682)3.01651432
78positive regulation of response to nutrient levels (GO:0032109)3.00856372
79positive regulation of response to extracellular stimulus (GO:0032106)3.00856372
80regulation of neurotransmitter uptake (GO:0051580)2.99442552
81ER overload response (GO:0006983)2.98256033
82positive regulation of histone H3-K4 methylation (GO:0051571)2.96536630
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95307484
84* peptide hormone processing (GO:0016486)2.94757513
85locomotory exploration behavior (GO:0035641)2.92617075
86zinc ion homeostasis (GO:0055069)2.92434881
87neurotransmitter transport (GO:0006836)2.92113412
88positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91878518
89startle response (GO:0001964)2.91223821
90regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.90488287
91positive regulation of calcium ion import (GO:0090280)2.90325119
92regulation of peptide secretion (GO:0002791)2.89246892
93synaptic vesicle maturation (GO:0016188)2.88132653
94regulation of autophagic vacuole assembly (GO:2000785)2.87970977
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.86965875
96L-phenylalanine catabolic process (GO:0006559)2.86965875
97innervation (GO:0060384)2.85655357
98positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.83137777
99regulation of long-term neuronal synaptic plasticity (GO:0048169)2.83042822
100proline transport (GO:0015824)2.82896699
101endocrine pancreas development (GO:0031018)2.82646651
102positive regulation of exocytosis (GO:0045921)2.82513343
103positive regulation of vesicle fusion (GO:0031340)2.82244213
104regulation of insulin secretion (GO:0050796)2.81922005
105regulation of oxidative phosphorylation (GO:0002082)2.80899202
106negative regulation of protein oligomerization (GO:0032460)2.80429819
107synaptic vesicle endocytosis (GO:0048488)2.80102622
108regulation of calcium ion-dependent exocytosis (GO:0017158)2.79692182
109exploration behavior (GO:0035640)2.79540498
110response to histamine (GO:0034776)2.79399024
111regulation of glutamate secretion (GO:0014048)2.79268970
112establishment of synaptic vesicle localization (GO:0097480)2.78514798
113synaptic vesicle transport (GO:0048489)2.78514798
114activation of protein kinase A activity (GO:0034199)2.78270045
115positive regulation of synapse assembly (GO:0051965)2.77757749
116positive regulation of meiosis (GO:0045836)2.77459459
117positive regulation of neurotransmitter transport (GO:0051590)2.77047433
118regulation of excitatory postsynaptic membrane potential (GO:0060079)2.76015770
119serotonin metabolic process (GO:0042428)2.75714720
120negative regulation of hormone metabolic process (GO:0032351)2.74832870
121regulation of neuronal synaptic plasticity (GO:0048168)2.73470312
122neuromuscular process controlling posture (GO:0050884)2.72944353
123negative regulation of amine transport (GO:0051953)2.72875062
124protein targeting to Golgi (GO:0000042)2.72679657
125protein localization to Golgi apparatus (GO:0034067)2.72339828
126regulation of postsynaptic membrane potential (GO:0060078)2.71362428
127alanine transport (GO:0032328)2.70665350
128respiratory electron transport chain (GO:0022904)2.70349094
129regulation of exocytosis (GO:0017157)2.70321806
130kidney morphogenesis (GO:0060993)2.70076809
131positive regulation of hormone secretion (GO:0046887)2.69297394
132synaptic transmission, dopaminergic (GO:0001963)2.68697445
133positive regulation of membrane potential (GO:0045838)2.68050787
134negative regulation of neurotransmitter transport (GO:0051589)2.67872889
135behavioral response to cocaine (GO:0048148)2.67023544
136electron transport chain (GO:0022900)2.66436432
137protein localization to cilium (GO:0061512)2.65689858
138dendritic spine morphogenesis (GO:0060997)2.65524457
139type B pancreatic cell development (GO:0003323)2.65033031
140calcium ion import (GO:0070509)2.64749184
141regulation of type B pancreatic cell apoptotic process (GO:2000674)2.63401884
142chemosensory behavior (GO:0007635)2.63383899
143dentate gyrus development (GO:0021542)2.63378457
144erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.63137365
145L-phenylalanine metabolic process (GO:0006558)2.63137365
146calcium-mediated signaling using intracellular calcium source (GO:0035584)2.62583785
147nephron tubule morphogenesis (GO:0072078)2.62528692
148nephron epithelium morphogenesis (GO:0072088)2.62528692
149synaptic vesicle docking involved in exocytosis (GO:0016081)2.62488391
150calcium ion-dependent exocytosis (GO:0017156)2.62280110
151transmission of nerve impulse (GO:0019226)2.62258394
152negative regulation of catecholamine secretion (GO:0033604)2.61699643
153cellular zinc ion homeostasis (GO:0006882)2.60907661
154cellular response to glucagon stimulus (GO:0071377)2.60867424
155peptide transport (GO:0015833)2.60442037
156renal tubule morphogenesis (GO:0061333)2.60105548
157regulation of vacuole organization (GO:0044088)2.60083053
158striatum development (GO:0021756)2.59918054
159regulation of energy homeostasis (GO:2000505)2.58823891
160positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.58602206
161mating behavior (GO:0007617)2.58218711
162regulation of neurotransmitter levels (GO:0001505)2.57693180
163positive regulation of amino acid transport (GO:0051957)2.57544175
164regulation of peptide hormone secretion (GO:0090276)2.57067929
165regulation of neurotransmitter secretion (GO:0046928)2.56717528
166regulation of synaptic transmission, glutamatergic (GO:0051966)2.56666986
167brain morphogenesis (GO:0048854)2.56065863
168adult feeding behavior (GO:0008343)2.55674533
169positive regulation of meiotic cell cycle (GO:0051446)2.55495935
170pteridine-containing compound biosynthetic process (GO:0042559)2.53654056
171intra-Golgi vesicle-mediated transport (GO:0006891)2.53454330
172negative regulation of neurological system process (GO:0031645)2.53229061
173establishment of protein localization to Golgi (GO:0072600)2.53066425
174regulation of protein glycosylation (GO:0060049)2.52402675
175* regulation of hormone secretion (GO:0046883)2.51568440
176phenylpropanoid metabolic process (GO:0009698)2.48271928
177retinol metabolic process (GO:0042572)2.48068939
178hormone secretion (GO:0046879)2.48056066
179protein complex biogenesis (GO:0070271)2.46528602
180astrocyte differentiation (GO:0048708)2.45516193
181cardiac left ventricle morphogenesis (GO:0003214)2.44060852
182nodal signaling pathway (GO:0038092)2.43807631
183axoneme assembly (GO:0035082)2.43459433
184regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.43415264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.40746581
2GBX2_23144817_ChIP-Seq_PC3_Human3.98369528
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.38106742
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86137842
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69968551
6REST_21632747_ChIP-Seq_MESCs_Mouse2.66812388
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58288990
8TAF15_26573619_Chip-Seq_HEK293_Human2.43180964
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37938481
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36256641
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32826747
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27941750
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.27921371
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27144456
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25683560
16VDR_22108803_ChIP-Seq_LS180_Human2.20682601
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16832564
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.16383453
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13193051
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13007838
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07741735
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04198484
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04198484
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.03566813
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02896262
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96164847
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95281284
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.94763294
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92224109
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.89940413
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87898112
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.86932351
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.86551533
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85627855
35SMAD4_21799915_ChIP-Seq_A2780_Human1.84201361
36IGF1R_20145208_ChIP-Seq_DFB_Human1.78296715
37P300_19829295_ChIP-Seq_ESCs_Human1.75822565
38ZNF274_21170338_ChIP-Seq_K562_Hela1.74811960
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.71541240
40HTT_18923047_ChIP-ChIP_STHdh_Human1.67640880
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67097251
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.66457951
43FUS_26573619_Chip-Seq_HEK293_Human1.62084629
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.59329354
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58728754
46DROSHA_22980978_ChIP-Seq_HELA_Human1.57017312
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56420617
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53072659
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51065317
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45520917
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45414945
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.39783752
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.39496251
54* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38084730
55TP53_22573176_ChIP-Seq_HFKS_Human1.35923339
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35196724
57STAT3_23295773_ChIP-Seq_U87_Human1.33072481
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31658886
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.31439004
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29945023
61RNF2_27304074_Chip-Seq_NSC_Mouse1.28099922
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27418201
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.26592792
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24856298
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.24742251
66AR_25329375_ChIP-Seq_VCAP_Human1.23374725
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21234706
68EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19894320
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18821870
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18760468
71* STAT3_18555785_Chip-Seq_ESCs_Mouse1.18349042
72TCF4_23295773_ChIP-Seq_U87_Human1.18271342
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18003820
74RUNX2_22187159_ChIP-Seq_PCA_Human1.17786558
75CDX2_22108803_ChIP-Seq_LS180_Human1.17733017
76EWS_26573619_Chip-Seq_HEK293_Human1.17178658
77NANOG_19829295_ChIP-Seq_ESCs_Human1.16571774
78SOX2_19829295_ChIP-Seq_ESCs_Human1.16571774
79* NANOG_18555785_Chip-Seq_ESCs_Mouse1.15998900
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15947265
81TCF4_22108803_ChIP-Seq_LS180_Human1.15930044
82* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15810628
83* FOXA1_25329375_ChIP-Seq_VCAP_Human1.15810628
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15298241
85* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13752241
86* SOX2_18555785_Chip-Seq_ESCs_Mouse1.13213965
87BCAT_22108803_ChIP-Seq_LS180_Human1.13157167
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12771191
89ER_23166858_ChIP-Seq_MCF-7_Human1.12267625
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11503140
91* E2F1_18555785_Chip-Seq_ESCs_Mouse1.10545523
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10178979
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08829939
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08545739
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08005102
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07429681
97REST_19997604_ChIP-ChIP_NEURONS_Mouse1.07341829
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07261257
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06656697
100AR_21572438_ChIP-Seq_LNCaP_Human1.06466647
101P300_18555785_Chip-Seq_ESCs_Mouse1.06266136
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04529038
103EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04301993
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03411286
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.02772535
106JUN_21703547_ChIP-Seq_K562_Human1.02057375
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.02043795
108* CTCF_18555785_Chip-Seq_ESCs_Mouse1.01933891
109* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01550237
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00931630
111* NMYC_18555785_Chip-Seq_ESCs_Mouse1.00770328
112CRX_20693478_ChIP-Seq_RETINA_Mouse0.99831253
113FLI1_21867929_ChIP-Seq_TH2_Mouse0.99798402
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99027103
115P53_22387025_ChIP-Seq_ESCs_Mouse0.97839588
116CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97660236
117AR_20517297_ChIP-Seq_VCAP_Human0.97590407
118AR_19668381_ChIP-Seq_PC3_Human0.97557903
119YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97396997
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.97306484
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96942257
122KDM2B_26808549_Chip-Seq_REH_Human0.95193805
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94472266
124* OCT4_18555785_Chip-Seq_ESCs_Mouse0.94263216
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93965867
126ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93960795
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.93730028
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93250916
129ARNT_22903824_ChIP-Seq_MCF-7_Human0.91950601
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91913571
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91696684
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91471210
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90860651
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.90461304
135CMYC_18555785_Chip-Seq_ESCs_Mouse0.90456589
136P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87154646
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87064958
138CBP_20019798_ChIP-Seq_JUKART_Human0.87064958

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.42217564
2MP0004859_abnormal_synaptic_plasticity3.65704280
3MP0004270_analgesia3.23392841
4MP0003635_abnormal_synaptic_transmissio3.22866281
5MP0010234_abnormal_vibrissa_follicle3.10701737
6MP0002909_abnormal_adrenal_gland2.87290730
7MP0010386_abnormal_urinary_bladder2.81064110
8MP0009745_abnormal_behavioral_response2.79905704
9MP0009780_abnormal_chondrocyte_physiolo2.71961621
10MP0002063_abnormal_learning/memory/cond2.61026676
11MP0008877_abnormal_DNA_methylation2.57941230
12MP0002139_abnormal_hepatobiliary_system2.55046992
13MP0002572_abnormal_emotion/affect_behav2.54795970
14* MP0002064_seizures2.53259647
15MP0001968_abnormal_touch/_nociception2.50403921
16MP0002734_abnormal_mechanical_nocicepti2.39855556
17MP0002272_abnormal_nervous_system2.37686276
18MP0009046_muscle_twitch2.36664680
19MP0005645_abnormal_hypothalamus_physiol2.33785970
20MP0006276_abnormal_autonomic_nervous2.32046353
21MP0001529_abnormal_vocalization2.28797789
22MP0004043_abnormal_pH_regulation2.25353162
23MP0003122_maternal_imprinting2.20814361
24MP0001501_abnormal_sleep_pattern2.18462233
25MP0002736_abnormal_nociception_after2.09769262
26MP0002733_abnormal_thermal_nociception2.05543782
27MP0005646_abnormal_pituitary_gland2.05189561
28MP0003283_abnormal_digestive_organ2.00164212
29MP0003183_abnormal_peptide_metabolism1.99418092
30MP0001440_abnormal_grooming_behavior1.99000542
31MP0002735_abnormal_chemical_nociception1.96934179
32MP0001486_abnormal_startle_reflex1.90349372
33MP0001970_abnormal_pain_threshold1.90331220
34MP0002693_abnormal_pancreas_physiology1.88397522
35MP0002254_reproductive_system_inflammat1.86945213
36MP0002822_catalepsy1.82869002
37MP0002067_abnormal_sensory_capabilities1.79907044
38MP0006072_abnormal_retinal_apoptosis1.74859220
39MP0010329_abnormal_lipoprotein_level1.74238331
40MP0004019_abnormal_vitamin_homeostasis1.70971125
41MP0001984_abnormal_olfaction1.70692042
42MP0002184_abnormal_innervation1.70342840
43MP0002638_abnormal_pupillary_reflex1.69568858
44MP0001188_hyperpigmentation1.67866344
45MP0001905_abnormal_dopamine_level1.66507996
46MP0001756_abnormal_urination1.65509231
47MP0003123_paternal_imprinting1.65378972
48MP0003172_abnormal_lysosome_physiology1.64415058
49MP0003195_calcinosis1.64366045
50MP0002557_abnormal_social/conspecific_i1.63618469
51MP0002876_abnormal_thyroid_physiology1.62018926
52MP0005332_abnormal_amino_acid1.61770698
53MP0003787_abnormal_imprinting1.59205084
54MP0001502_abnormal_circadian_rhythm1.58994605
55MP0005386_behavior/neurological_phenoty1.57872723
56MP0004924_abnormal_behavior1.57872723
57MP0005423_abnormal_somatic_nervous1.55591426
58* MP0000013_abnormal_adipose_tissue1.55062259
59* MP0001944_abnormal_pancreas_morphology1.54650257
60MP0003329_amyloid_beta_deposits1.52456109
61MP0003879_abnormal_hair_cell1.46060944
62MP0001986_abnormal_taste_sensitivity1.40027750
63MP0000678_abnormal_parathyroid_gland1.39590253
64MP0000955_abnormal_spinal_cord1.33549282
65MP0005084_abnormal_gallbladder_morpholo1.32819711
66* MP0005379_endocrine/exocrine_gland_phen1.28931769
67MP0000778_abnormal_nervous_system1.28099212
68MP0002928_abnormal_bile_duct1.25606950
69MP0002877_abnormal_melanocyte_morpholog1.23257357
70MP0004133_heterotaxia1.21570502
71MP0002066_abnormal_motor_capabilities/c1.20531773
72MP0000427_abnormal_hair_cycle1.19313922
73MP0004142_abnormal_muscle_tone1.18715904
74MP0004811_abnormal_neuron_physiology1.17912817
75MP0008569_lethality_at_weaning1.17592681
76MP0005365_abnormal_bile_salt1.16613630
77MP0003011_delayed_dark_adaptation1.15867689
78MP0002938_white_spotting1.14937403
79MP0002882_abnormal_neuron_morphology1.14581323
80MP0004145_abnormal_muscle_electrophysio1.14459476
81MP0010678_abnormal_skin_adnexa1.12890801
82MP0005551_abnormal_eye_electrophysiolog1.11797390
83MP0000569_abnormal_digit_pigmentation1.10671131
84* MP0002078_abnormal_glucose_homeostasis1.09814058
85* MP0005535_abnormal_body_temperature1.07749231
86MP0005075_abnormal_melanosome_morpholog1.05844687
87* MP0005636_abnormal_mineral_homeostasis1.04546222
88MP0003633_abnormal_nervous_system1.02696782
89MP0002229_neurodegeneration1.01813523
90* MP0000631_abnormal_neuroendocrine_gland1.01390377
91MP0005174_abnormal_tail_pigmentation0.98967684
92MP0001664_abnormal_digestion0.97861889
93MP0002118_abnormal_lipid_homeostasis0.96978911
94* MP0002069_abnormal_eating/drinking_beha0.94638331
95* MP0001765_abnormal_ion_homeostasis0.92354953
96MP0006036_abnormal_mitochondrial_physio0.91317279
97MP0004858_abnormal_nervous_system0.89725492
98MP0000516_abnormal_urinary_system0.89705858
99MP0005367_renal/urinary_system_phenotyp0.89705858
100MP0002234_abnormal_pharynx_morphology0.88258716
101MP0008872_abnormal_physiological_respon0.87411965
102MP0004085_abnormal_heartbeat0.84797092
103MP0005253_abnormal_eye_physiology0.83918840
104* MP0003953_abnormal_hormone_level0.81468503
105MP0005409_darkened_coat_color0.81213555
106MP0003631_nervous_system_phenotype0.81049099
107MP0001963_abnormal_hearing_physiology0.80637650
108MP0004742_abnormal_vestibular_system0.80291843
109* MP0002837_dystrophic_cardiac_calcinosis0.80026155
110MP0005389_reproductive_system_phenotype0.78793318
111MP0006292_abnormal_olfactory_placode0.78474966
112MP0004885_abnormal_endolymph0.78375155
113MP0000538_abnormal_urinary_bladder0.77523322
114* MP0002152_abnormal_brain_morphology0.77373649
115MP0003634_abnormal_glial_cell0.75884280
116MP0005452_abnormal_adipose_tissue0.74909929
117MP0005248_abnormal_Harderian_gland0.74837440
118MP0003121_genomic_imprinting0.71593336
119MP0002102_abnormal_ear_morphology0.71474223
120MP0000462_abnormal_digestive_system0.70518849
121MP0000015_abnormal_ear_pigmentation0.70342503
122MP0005220_abnormal_exocrine_pancreas0.69899479
123MP0002751_abnormal_autonomic_nervous0.68097607
124MP0009643_abnormal_urine_homeostasis0.67880319
125MP0002160_abnormal_reproductive_system0.67733043
126MP0005394_taste/olfaction_phenotype0.67391633
127MP0005499_abnormal_olfactory_system0.67391633
128MP0000230_abnormal_systemic_arterial0.66909846
129MP0002090_abnormal_vision0.66599208
130MP0003959_abnormal_lean_body0.66136438
131MP0001485_abnormal_pinna_reflex0.65830415
132MP0005448_abnormal_energy_balance0.65170079
133MP0002752_abnormal_somatic_nervous0.63799496
134MP0008961_abnormal_basal_metabolism0.63345661
135MP0004215_abnormal_myocardial_fiber0.62198624

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.01993357
2Visual hallucinations (HP:0002367)4.72795457
3Atonic seizures (HP:0010819)4.50764093
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.45008174
5Epileptic encephalopathy (HP:0200134)3.94644859
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.87106368
7Hyperinsulinemic hypoglycemia (HP:0000825)3.84770640
8Focal seizures (HP:0007359)3.80624761
9Absence seizures (HP:0002121)3.78249941
10Acute necrotizing encephalopathy (HP:0006965)3.65749027
11Intestinal atresia (HP:0011100)3.49101407
12Dialeptic seizures (HP:0011146)3.43152809
13Abnormal mitochondria in muscle tissue (HP:0008316)3.39184952
14Febrile seizures (HP:0002373)3.34589758
15Double outlet right ventricle (HP:0001719)3.29541394
16Congenital malformation of the right heart (HP:0011723)3.29541394
17Pheochromocytoma (HP:0002666)3.29021600
18Hyperventilation (HP:0002883)3.27730978
19Abnormality of calcium-phosphate metabolism (HP:0100530)3.25519462
20Progressive macrocephaly (HP:0004481)3.23519301
21Symptomatic seizures (HP:0011145)3.22741306
22Epileptiform EEG discharges (HP:0011182)3.19217626
23Hypoglycemic seizures (HP:0002173)3.18688462
24Ketosis (HP:0001946)3.12237292
25EEG with generalized epileptiform discharges (HP:0011198)3.08360234
26Abnormality of vitamin B metabolism (HP:0004340)3.07036997
27Agitation (HP:0000713)3.06277868
28Neuroendocrine neoplasm (HP:0100634)3.05635440
29Generalized tonic-clonic seizures (HP:0002069)3.04625068
30Hypothermia (HP:0002045)2.97068098
31Enlarged penis (HP:0000040)2.96821542
32Hypsarrhythmia (HP:0002521)2.88087368
33Limb dystonia (HP:0002451)2.87284693
34Acute encephalopathy (HP:0006846)2.83228390
35Anxiety (HP:0000739)2.81398036
36Mitochondrial inheritance (HP:0001427)2.81118423
37Myokymia (HP:0002411)2.78137227
38Cerebral inclusion bodies (HP:0100314)2.77929819
39Gait imbalance (HP:0002141)2.75891051
40Decreased circulating renin level (HP:0003351)2.74006447
41Increased CSF protein (HP:0002922)2.67988831
42Medial flaring of the eyebrow (HP:0010747)2.66790850
43Amblyopia (HP:0000646)2.63361552
44Hypomagnesemia (HP:0002917)2.60561643
45Congenital primary aphakia (HP:0007707)2.60264655
46Dysautonomia (HP:0002459)2.59737328
47Methylmalonic acidemia (HP:0002912)2.51424224
48Abnormality of vitamin metabolism (HP:0100508)2.48730856
49Neurofibrillary tangles (HP:0002185)2.46565278
50Progressive cerebellar ataxia (HP:0002073)2.44988321
51Truncal ataxia (HP:0002078)2.42758570
52Ketoacidosis (HP:0001993)2.40716813
53Nephrogenic diabetes insipidus (HP:0009806)2.40490240
54Pancreatic fibrosis (HP:0100732)2.38127619
55Insulin-resistant diabetes mellitus (HP:0000831)2.34124169
56Polydipsia (HP:0001959)2.31883728
57Abnormal drinking behavior (HP:0030082)2.31883728
58Supranuclear gaze palsy (HP:0000605)2.30004048
59Retinal dysplasia (HP:0007973)2.29106931
60Abnormality of the renal cortex (HP:0011035)2.28955783
61Abnormality of urine glucose concentration (HP:0011016)2.26187499
62Glycosuria (HP:0003076)2.26187499
63Abnormal albumin level (HP:0012116)2.25078442
64Hypoalbuminemia (HP:0003073)2.25078442
65Failure to thrive in infancy (HP:0001531)2.24187145
66Hemiparesis (HP:0001269)2.23218771
67Drooling (HP:0002307)2.22118000
68Excessive salivation (HP:0003781)2.22118000
69Progressive neurologic deterioration (HP:0002344)2.21750110
70Type II lissencephaly (HP:0007260)2.20646673
71Tongue fasciculations (HP:0001308)2.20021703
72Depression (HP:0000716)2.19797929
73Increased CSF lactate (HP:0002490)2.19713328
74Pancreatic cysts (HP:0001737)2.17122245
75Proximal tubulopathy (HP:0000114)2.15597414
76Hypokinesia (HP:0002375)2.14565016
77Hematochezia (HP:0002573)2.14263032
78Hepatic necrosis (HP:0002605)2.14087570
79Conjunctival hamartoma (HP:0100780)2.13919828
80Nephronophthisis (HP:0000090)2.12982195
81Hyperglycemia (HP:0003074)2.11798184
82Prominent metopic ridge (HP:0005487)2.11293590
83Abnormality of the pancreatic islet cells (HP:0006476)2.11184239
84Abnormality of endocrine pancreas physiology (HP:0012093)2.11184239
85Hyperphosphatemia (HP:0002905)2.10973465
86Vascular calcification (HP:0004934)2.10214572
87Genital tract atresia (HP:0001827)2.09839338
88Vaginal atresia (HP:0000148)2.09389911
89Large for gestational age (HP:0001520)2.07527657
90Broad-based gait (HP:0002136)2.07415699
91Retinal atrophy (HP:0001105)2.06531132
92Testicular neoplasm (HP:0010788)2.05575635
93Hamartoma of the eye (HP:0010568)2.04789900
94Psychosis (HP:0000709)2.04549029
95Methylmalonic aciduria (HP:0012120)2.04002940
96Congenital sensorineural hearing impairment (HP:0008527)2.00478706
97Menstrual irregularities (HP:0000858)2.00451894
98Neoplasm of the adrenal cortex (HP:0100641)2.00132249
99Optic disc pallor (HP:0000543)2.00092963
100Sex reversal (HP:0012245)1.99979964
101Abnormal sex determination (HP:0012244)1.99979964
102Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99741499
103Abnormality of polysaccharide metabolism (HP:0011012)1.99741499
104Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99741499
105Postural tremor (HP:0002174)1.97523400
106Abnormal autonomic nervous system physiology (HP:0012332)1.97334377
107Abnormality of the metopic suture (HP:0005556)1.97279416
108Resting tremor (HP:0002322)1.96687811
109Furrowed tongue (HP:0000221)1.95893294
110Protruding tongue (HP:0010808)1.95751376
111Tubular atrophy (HP:0000092)1.94867820
112Aqueductal stenosis (HP:0002410)1.94146619
113Aplasia/Hypoplasia of the fovea (HP:0008060)1.94067239
114Hypoplasia of the fovea (HP:0007750)1.94067239
115Blue irides (HP:0000635)1.92010979
116Abnormality of magnesium homeostasis (HP:0004921)1.90769725
117Restlessness (HP:0000711)1.90368193
118Mucopolysacchariduria (HP:0008155)1.90048710
119Urinary glycosaminoglycan excretion (HP:0003541)1.90048710
120Unilateral renal agenesis (HP:0000122)1.89667074
121Pancreatic islet-cell hyperplasia (HP:0004510)1.89197332
122Delusions (HP:0000746)1.88950365
123Hypoglycemic coma (HP:0001325)1.88257821
124Molar tooth sign on MRI (HP:0002419)1.87534700
125Abnormality of midbrain morphology (HP:0002418)1.87534700
126Abnormal eating behavior (HP:0100738)1.87078501
127Hyperthyroidism (HP:0000836)1.86714835
128Progressive inability to walk (HP:0002505)1.86367485
129Renal cortical cysts (HP:0000803)1.85803256
130Diminished movement (HP:0002374)1.85758409
131Cortical visual impairment (HP:0100704)1.85700188
132Oligomenorrhea (HP:0000876)1.85272083
133Abnormal hair whorl (HP:0010721)1.84308321
134Orthostatic hypotension (HP:0001278)1.84206487
135Increased circulating renin level (HP:0000848)1.82797717
136Impaired smooth pursuit (HP:0007772)1.81732771
137Papilledema (HP:0001085)1.81375490
138Hepatocellular necrosis (HP:0001404)1.81250240
139Absent speech (HP:0001344)1.80945374
140Abnormality of renin-angiotensin system (HP:0000847)1.80927595
141Poor eye contact (HP:0000817)1.80745306
142Abnormal pancreas size (HP:0012094)1.80553086
143Hyperparathyroidism (HP:0000843)1.80425135
144True hermaphroditism (HP:0010459)1.80402473
145Abnormality of the renal medulla (HP:0100957)1.79142760
146Muscle fibrillation (HP:0010546)1.78366059
147Polyphagia (HP:0002591)1.78046400
148Late onset (HP:0003584)1.78013424
1493-Methylglutaconic aciduria (HP:0003535)1.77687845
150Poor suck (HP:0002033)1.76203286
151Aplasia/Hypoplasia of the lens (HP:0008063)1.73403927
152Muscular hypotonia of the trunk (HP:0008936)1.72805498
153Hypokalemia (HP:0002900)1.72454312
154Dysmetria (HP:0001310)1.72209558
155Increased hepatocellular lipid droplets (HP:0006565)1.72034039
156Abnormality of binocular vision (HP:0011514)1.71840141
157Diplopia (HP:0000651)1.71840141
158Bradykinesia (HP:0002067)1.71171204
159Gaze-evoked nystagmus (HP:0000640)1.70970284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.96817657
2FGFR23.37802526
3CASK3.37372662
4INSRR3.35329539
5EPHA43.08503170
6PHKG22.96406015
7PHKG12.96406015
8MAP3K42.93834349
9MAP2K72.81981365
10MAP3K122.68788936
11MST42.60018125
12MAP4K22.55598542
13MAPK152.54000855
14RIPK42.36737922
15PNCK2.27052381
16MAP3K92.23756909
17WNK32.21379784
18GRK12.12987643
19NTRK12.06181279
20ARAF2.03134870
21MAP2K62.02981933
22PINK11.88489208
23WNK41.82211064
24GRK51.82060987
25UHMK11.77859975
26NME11.76073564
27PLK21.73377385
28MAP2K41.72603766
29BMPR21.71844342
30MINK11.67623323
31MARK11.65193452
32PRKD31.64675800
33CAMKK21.63687420
34FGFR31.62880163
35PASK1.59405943
36MAP3K21.59226223
37FRK1.49928973
38DAPK21.43146042
39NLK1.42217689
40DAPK11.42135089
41CSNK1G11.33329843
42TRPM71.31073736
43AKT31.28180210
44STK31.23970201
45KSR21.22468021
46NTRK21.22000341
47ACVR1B1.21105837
48CDK51.20700623
49HIPK21.19901354
50CAMK2B1.19272398
51CAMK2A1.16597107
52STK241.14693557
53EPHA31.13040507
54STK38L1.10731313
55BRAF1.09779198
56PRKCG1.09144820
57TAOK31.08378590
58MAPK131.08160325
59GRK71.05266824
60PRKCE1.00974851
61CDK191.00905327
62PAK30.99100579
63ERBB30.96542317
64MAP3K10.95511353
65PAK60.93047684
66TAOK10.92174627
67CAMK2D0.92086494
68TNIK0.86995320
69OXSR10.86863117
70KSR10.86243283
71STK110.85226507
72MAP3K130.82672479
73MKNK20.80496421
74DYRK1A0.80126860
75ADRBK20.79516584
76BCR0.77088326
77PTK2B0.76965880
78SGK2230.73940110
79SGK4940.73940110
80TRIM280.72728271
81SIK20.72667673
82FES0.72558026
83YES10.72140142
84FGR0.71631846
85PIK3CG0.70417248
86FER0.70131174
87ADRBK10.69700074
88ZAK0.69211992
89TNK20.68075869
90PRKAA10.67585423
91STK160.67552744
92IRAK10.67416466
93CCNB10.65905766
94PRKCI0.65447611
95PRKCH0.64836875
96WNK10.64488699
97PRKAA20.64483515
98CAMKK10.63034497
99CSNK1G20.60907460
100LIMK10.60564561
101CAMK1G0.60018126
102CDC42BPA0.59452710
103CSNK1A1L0.58835501
104CAMK2G0.57274445
105BMPR1B0.55961872
106CDK140.54237771
107PRKACA0.53676476
108SGK10.52011566
109STK40.50985197
110RET0.50419796
111CDK180.49020425
112SGK20.46395959
113SIK30.45834196
114PLK30.45337701
115CDK150.45331855
116PRKD20.45202910
117MAP2K10.43830342
118MUSK0.41927385
119RAF10.40663789
120CSNK1D0.40097879
121PRKCZ0.39404749
122PRKG20.38828516
123SCYL20.37686099
124CDK11A0.37538797
125STK390.37078773
126PRKACB0.36359456
127GRK60.36022592
128CSNK1A10.35638002
129PRKCA0.35211183
130MAPKAPK50.34377566
131CDK30.32157524
132MYLK0.31550716
133GSK3A0.31305316
134RPS6KA30.30971512
135MAPK100.30726534
136CSNK1G30.30684196
137CSNK1E0.30617778
138CAMK10.30124143
139NUAK10.29753067
140PRKCB0.29542914
141PRKG10.28613981
142STK380.27767900
143EIF2AK30.27702778
144TLK10.24659996
145SGK30.24617595

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.62866411
2Nicotine addiction_Homo sapiens_hsa050333.11108323
3Synaptic vesicle cycle_Homo sapiens_hsa047212.97959493
4Collecting duct acid secretion_Homo sapiens_hsa049662.84634509
5Oxidative phosphorylation_Homo sapiens_hsa001902.77542044
6Insulin secretion_Homo sapiens_hsa049112.74118502
7Protein export_Homo sapiens_hsa030602.70479593
8Amphetamine addiction_Homo sapiens_hsa050312.49623296
9Vibrio cholerae infection_Homo sapiens_hsa051102.43805949
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39614131
11GABAergic synapse_Homo sapiens_hsa047272.33827379
12Vitamin B6 metabolism_Homo sapiens_hsa007502.26712648
13Long-term potentiation_Homo sapiens_hsa047202.25809170
14Taste transduction_Homo sapiens_hsa047422.19963725
15Folate biosynthesis_Homo sapiens_hsa007902.17318610
16Circadian entrainment_Homo sapiens_hsa047132.14991546
17Morphine addiction_Homo sapiens_hsa050322.07873361
18Dopaminergic synapse_Homo sapiens_hsa047282.03939922
19Parkinsons disease_Homo sapiens_hsa050122.01395124
20Alzheimers disease_Homo sapiens_hsa050102.00763431
21Cocaine addiction_Homo sapiens_hsa050301.98504101
22Serotonergic synapse_Homo sapiens_hsa047261.89688755
23Glutamatergic synapse_Homo sapiens_hsa047241.85540202
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72835611
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72553058
26Selenocompound metabolism_Homo sapiens_hsa004501.68598875
27Olfactory transduction_Homo sapiens_hsa047401.68199024
28Renin secretion_Homo sapiens_hsa049241.66205601
29Type I diabetes mellitus_Homo sapiens_hsa049401.54605811
30Salivary secretion_Homo sapiens_hsa049701.54432754
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54227586
32Long-term depression_Homo sapiens_hsa047301.48951626
33Cholinergic synapse_Homo sapiens_hsa047251.48354923
34Sulfur metabolism_Homo sapiens_hsa009201.45766085
35Fatty acid elongation_Homo sapiens_hsa000621.43058630
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42526805
37Huntingtons disease_Homo sapiens_hsa050161.36922267
38Type II diabetes mellitus_Homo sapiens_hsa049301.31909759
39Cardiac muscle contraction_Homo sapiens_hsa042601.31637564
40Gastric acid secretion_Homo sapiens_hsa049711.30441823
41Tryptophan metabolism_Homo sapiens_hsa003801.28864746
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21632877
43Peroxisome_Homo sapiens_hsa041461.20469819
44Calcium signaling pathway_Homo sapiens_hsa040201.19280413
45Oxytocin signaling pathway_Homo sapiens_hsa049211.09388059
46Phototransduction_Homo sapiens_hsa047441.07548418
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06989605
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06739628
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04028743
50Propanoate metabolism_Homo sapiens_hsa006401.03534013
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00526425
52Pancreatic secretion_Homo sapiens_hsa049721.00092047
53Mineral absorption_Homo sapiens_hsa049780.98410392
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94325692
55GnRH signaling pathway_Homo sapiens_hsa049120.93505686
56Estrogen signaling pathway_Homo sapiens_hsa049150.93457697
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.92712433
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91688262
59Gap junction_Homo sapiens_hsa045400.91063365
60ABC transporters_Homo sapiens_hsa020100.89988959
61Thyroid hormone synthesis_Homo sapiens_hsa049180.89468141
62cAMP signaling pathway_Homo sapiens_hsa040240.88153479
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86672271
64Glucagon signaling pathway_Homo sapiens_hsa049220.86516326
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85374600
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84388468
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83746032
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82811255
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81875463
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81847123
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79986539
72beta-Alanine metabolism_Homo sapiens_hsa004100.78178110
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77596311
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76917440
75Arginine biosynthesis_Homo sapiens_hsa002200.76585085
76Rheumatoid arthritis_Homo sapiens_hsa053230.75378649
77Linoleic acid metabolism_Homo sapiens_hsa005910.74123556
78Fatty acid metabolism_Homo sapiens_hsa012120.72788673
79Melanogenesis_Homo sapiens_hsa049160.72608864
80Circadian rhythm_Homo sapiens_hsa047100.72308110
81Regulation of autophagy_Homo sapiens_hsa041400.70534901
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.69875709
83Nitrogen metabolism_Homo sapiens_hsa009100.69851160
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.68399333
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66119049
86Alcoholism_Homo sapiens_hsa050340.64254590
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63949986
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63900631
89Metabolic pathways_Homo sapiens_hsa011000.58690372
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57851653
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57142217
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55532663
93Butanoate metabolism_Homo sapiens_hsa006500.54257437
94Fatty acid degradation_Homo sapiens_hsa000710.54157384
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54069174
96Glutathione metabolism_Homo sapiens_hsa004800.53373999
97Prion diseases_Homo sapiens_hsa050200.52054620
98N-Glycan biosynthesis_Homo sapiens_hsa005100.51676707
99Other glycan degradation_Homo sapiens_hsa005110.51184870
100Retinol metabolism_Homo sapiens_hsa008300.51095654
101Phagosome_Homo sapiens_hsa041450.51062714
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49385440
103Axon guidance_Homo sapiens_hsa043600.45313235
104Lysosome_Homo sapiens_hsa041420.42814897
105Glioma_Homo sapiens_hsa052140.41800745
106Caffeine metabolism_Homo sapiens_hsa002320.40018030
107ErbB signaling pathway_Homo sapiens_hsa040120.39263506
108Dorso-ventral axis formation_Homo sapiens_hsa043200.38949403
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38786332
110Arachidonic acid metabolism_Homo sapiens_hsa005900.38756109
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38619121
112Inositol phosphate metabolism_Homo sapiens_hsa005620.37021925
113Chemical carcinogenesis_Homo sapiens_hsa052040.36755013
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.36432690
115Oocyte meiosis_Homo sapiens_hsa041140.34337165
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34311182
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33112251
118Dilated cardiomyopathy_Homo sapiens_hsa054140.29055748
119MAPK signaling pathway_Homo sapiens_hsa040100.28712833
120Ras signaling pathway_Homo sapiens_hsa040140.28126273
121Phenylalanine metabolism_Homo sapiens_hsa003600.27925809
122Sphingolipid metabolism_Homo sapiens_hsa006000.27137267
123Ovarian steroidogenesis_Homo sapiens_hsa049130.23721148
124Insulin signaling pathway_Homo sapiens_hsa049100.22058213
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22003789
126Choline metabolism in cancer_Homo sapiens_hsa052310.21321067
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20672103
128African trypanosomiasis_Homo sapiens_hsa051430.20305378
129Pyruvate metabolism_Homo sapiens_hsa006200.20146023
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18995313
131Wnt signaling pathway_Homo sapiens_hsa043100.18059390
132Tyrosine metabolism_Homo sapiens_hsa003500.18042904
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.17617049
134Ether lipid metabolism_Homo sapiens_hsa005650.17448237
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14468966

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