SCFD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)8.37407503
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.00707021
3COPII vesicle coating (GO:0048208)6.27276053
4protein retention in ER lumen (GO:0006621)5.95311662
5protein maturation by protein folding (GO:0022417)5.75046256
6ER overload response (GO:0006983)5.66075365
7* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.26667383
8endocrine pancreas development (GO:0031018)5.18081901
9peptide hormone processing (GO:0016486)5.11101969
10nucleotide transmembrane transport (GO:1901679)4.87933943
11sequestering of metal ion (GO:0051238)4.67822373
12proteasome assembly (GO:0043248)4.38489952
13exocrine pancreas development (GO:0031017)4.26798728
14vesicle coating (GO:0006901)4.22896529
15GDP-mannose metabolic process (GO:0019673)4.11528988
16ER to Golgi vesicle-mediated transport (GO:0006888)4.10674222
17ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.07065234
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.04273789
19glandular epithelial cell differentiation (GO:0002067)3.99112473
20regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.98551971
21intra-Golgi vesicle-mediated transport (GO:0006891)3.93334574
22protein N-linked glycosylation via asparagine (GO:0018279)3.90889261
23peptidyl-asparagine modification (GO:0018196)3.83841457
24activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.83068925
25protein prenylation (GO:0018342)3.67796077
26prenylation (GO:0097354)3.67796077
27positive regulation of nuclease activity (GO:0032075)3.66525728
28regulation of type B pancreatic cell apoptotic process (GO:2000674)3.64748769
29misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.64255007
30protein N-linked glycosylation (GO:0006487)3.59873570
31cellular response to topologically incorrect protein (GO:0035967)3.53916031
32nucleotide-sugar biosynthetic process (GO:0009226)3.52046046
33DNA double-strand break processing (GO:0000729)3.52002918
34water-soluble vitamin biosynthetic process (GO:0042364)3.51267356
35endoplasmic reticulum unfolded protein response (GO:0030968)3.49672877
36L-phenylalanine catabolic process (GO:0006559)3.49196564
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.49196564
38cellular response to unfolded protein (GO:0034620)3.49187433
39regulation of mitotic spindle checkpoint (GO:1903504)3.49086835
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.49086835
41toxin metabolic process (GO:0009404)3.45623010
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44721623
43regulation of hexokinase activity (GO:1903299)3.44153013
44regulation of glucokinase activity (GO:0033131)3.44153013
45response to misfolded protein (GO:0051788)3.41209709
46protein complex biogenesis (GO:0070271)3.41207003
47regulation of nuclease activity (GO:0032069)3.41173984
48positive regulation of insulin secretion (GO:0032024)3.37285434
49branched-chain amino acid catabolic process (GO:0009083)3.36963228
50UDP-N-acetylglucosamine metabolic process (GO:0006047)3.35702362
51chromatin remodeling at centromere (GO:0031055)3.34114445
52CENP-A containing nucleosome assembly (GO:0034080)3.34108525
53ER-nucleus signaling pathway (GO:0006984)3.32982637
54cellular response to vitamin D (GO:0071305)3.32157850
55negative regulation of glycoprotein biosynthetic process (GO:0010561)3.31579042
56respiratory chain complex IV assembly (GO:0008535)3.30422953
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26708237
58mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.21231690
59mitochondrial respiratory chain complex assembly (GO:0033108)3.20901159
60peptidyl-histidine modification (GO:0018202)3.20543360
61dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.19571985
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19320716
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.19277411
64NADH dehydrogenase complex assembly (GO:0010257)3.19277411
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19277411
66cell redox homeostasis (GO:0045454)3.18666019
67lactate metabolic process (GO:0006089)3.18256164
68regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.14922284
69nucleotide-sugar metabolic process (GO:0009225)3.13236870
70viral protein processing (GO:0019082)3.11710607
71peptide catabolic process (GO:0043171)3.08301880
72organelle disassembly (GO:1903008)3.07656758
73protein neddylation (GO:0045116)3.06738835
74regulation of mitochondrial translation (GO:0070129)3.06441018
75response to endoplasmic reticulum stress (GO:0034976)3.05565515
76nucleoside diphosphate catabolic process (GO:0009134)3.03781870
77replication fork processing (GO:0031297)3.01586471
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01483457
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00057938
80peptide metabolic process (GO:0006518)2.97935530
81protein autoprocessing (GO:0016540)2.96753489
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96731156
83proline biosynthetic process (GO:0006561)2.96711611
843-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.96278460
85purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.96278460
86regulation of centriole replication (GO:0046599)2.96175093
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95698392
88oxidative phosphorylation (GO:0006119)2.94337348
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.93538002
90L-phenylalanine metabolic process (GO:0006558)2.93538002
91antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.91747303
92type B pancreatic cell development (GO:0003323)2.89235431
93protein localization to Golgi apparatus (GO:0034067)2.88904618
94regulation of cellular amino acid metabolic process (GO:0006521)2.88114996
95intestinal cholesterol absorption (GO:0030299)2.87398974
96RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.86084077
97cytochrome complex assembly (GO:0017004)2.85884008
98centriole replication (GO:0007099)2.85785779
99regulation of insulin secretion (GO:0050796)2.84584203
100nucleotide transport (GO:0006862)2.84373739
101protein deneddylation (GO:0000338)2.84167277
102response to topologically incorrect protein (GO:0035966)2.83730062
103histone mRNA metabolic process (GO:0008334)2.82325397
104GPI anchor biosynthetic process (GO:0006506)2.81705292
105detection of calcium ion (GO:0005513)2.81088171
106cullin deneddylation (GO:0010388)2.80348430
107response to unfolded protein (GO:0006986)2.80246447
108ribonucleoprotein complex disassembly (GO:0032988)2.80075232
109negative regulation of DNA-dependent DNA replication (GO:2000104)2.79256050
110chaperone-mediated protein folding (GO:0061077)2.78406008
111aldehyde catabolic process (GO:0046185)2.77618960
112histone exchange (GO:0043486)2.77375572
113synapsis (GO:0007129)2.77346207
114negative regulation of glycoprotein metabolic process (GO:1903019)2.77108936
115energy coupled proton transport, down electrochemical gradient (GO:0015985)2.77030929
116ATP synthesis coupled proton transport (GO:0015986)2.77030929
117RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76962806
118tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76962806
119resolution of meiotic recombination intermediates (GO:0000712)2.75932525
120protein-cofactor linkage (GO:0018065)2.73828779
121GMP metabolic process (GO:0046037)2.72995980
122negative regulation of norepinephrine secretion (GO:0010700)2.72792150
123ribosome assembly (GO:0042255)2.72312116
124positive regulation of peptide hormone secretion (GO:0090277)2.69961612
125regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.69513755
126positive regulation of receptor biosynthetic process (GO:0010870)2.68428951
127antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.68306225
128maturation of 5.8S rRNA (GO:0000460)2.67670373
129intraciliary transport (GO:0042073)2.67524896
130negative regulation of ligase activity (GO:0051352)2.67079637
131negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67079637
132insulin secretion (GO:0030073)2.67033444
133mannosylation (GO:0097502)2.66097665
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.65047618
135tRNA aminoacylation (GO:0043039)2.64356493
136amino acid activation (GO:0043038)2.64356493
137tRNA aminoacylation for protein translation (GO:0006418)2.63123310
138respiratory electron transport chain (GO:0022904)2.62620025
139* Golgi vesicle transport (GO:0048193)2.61991711
140regulation of Golgi to plasma membrane protein transport (GO:0042996)2.61545912
141keratan sulfate catabolic process (GO:0042340)2.61478587
142regulation of peptide hormone secretion (GO:0090276)2.61367355
143fucose metabolic process (GO:0006004)2.61257698
144positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.60806820
145electron transport chain (GO:0022900)2.60761015
146glycoside metabolic process (GO:0016137)2.60632652
147cholesterol biosynthetic process (GO:0006695)2.60028420
148pyrimidine-containing compound transmembrane transport (GO:0072531)2.59677705
149somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.59169243
150somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.59169243
151isotype switching (GO:0045190)2.59169243
152cellular response to hepatocyte growth factor stimulus (GO:0035729)2.57465261
153response to hepatocyte growth factor (GO:0035728)2.57465261
154ribonucleoside bisphosphate metabolic process (GO:0033875)2.57387413
155nucleoside bisphosphate metabolic process (GO:0033865)2.57387413
156purine nucleoside bisphosphate metabolic process (GO:0034032)2.57387413
157DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.57117240
158signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.57049600
159signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.57049600
160signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.57049600
161rRNA modification (GO:0000154)2.56446655
162negative regulation of JUN kinase activity (GO:0043508)2.56390633
163cellular response to antibiotic (GO:0071236)2.56389385
164positive regulation of peptide secretion (GO:0002793)2.55770806
165pteridine-containing compound biosynthetic process (GO:0042559)2.55439600
166postreplication repair (GO:0006301)2.54727760
167sterol biosynthetic process (GO:0016126)2.52226793
168preassembly of GPI anchor in ER membrane (GO:0016254)2.51150109
169signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.50873090
170intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.50873090
171cilium morphogenesis (GO:0060271)2.50667284
172positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.50066664
173tRNA metabolic process (GO:0006399)2.48238075
174L-methionine salvage (GO:0071267)2.48074035
175L-methionine biosynthetic process (GO:0071265)2.48074035
176amino acid salvage (GO:0043102)2.48074035
177positive regulation of histone H3-K4 methylation (GO:0051571)2.47927544
178termination of RNA polymerase III transcription (GO:0006386)2.47751302
179transcription elongation from RNA polymerase III promoter (GO:0006385)2.47751302
180cellular ketone body metabolic process (GO:0046950)2.46337394
181signal transduction involved in cell cycle checkpoint (GO:0072395)2.46196204
182rRNA methylation (GO:0031167)2.45843926
183regulation of acyl-CoA biosynthetic process (GO:0050812)2.45073061
184protein K11-linked ubiquitination (GO:0070979)2.44788092
185protein K6-linked ubiquitination (GO:0085020)2.44589101
186C-terminal protein lipidation (GO:0006501)2.44385275
187signal transduction involved in DNA integrity checkpoint (GO:0072401)2.44217151
188signal transduction involved in DNA damage checkpoint (GO:0072422)2.44217151
189COPI coating of Golgi vesicle (GO:0048205)10.4964897
190Golgi transport vesicle coating (GO:0048200)10.4964897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.27419084
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.47105282
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse4.21671816
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.94234822
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.03053394
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.02335328
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86694088
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.81011825
9ZNF274_21170338_ChIP-Seq_K562_Hela2.64650189
10GATA1_22025678_ChIP-Seq_K562_Human2.59776964
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.56107684
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.51124204
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.50113341
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47587658
15ELK1_19687146_ChIP-ChIP_HELA_Human2.39741357
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.38914181
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.34792555
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29297933
19IGF1R_20145208_ChIP-Seq_DFB_Human2.26929727
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.18523974
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.15573658
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15500800
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.14215960
24TAF15_26573619_Chip-Seq_HEK293_Human2.08578213
25EWS_26573619_Chip-Seq_HEK293_Human2.06439210
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01114589
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.99383819
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.99176496
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97270352
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.95435883
31* VDR_23849224_ChIP-Seq_CD4+_Human1.94913136
32* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93611745
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91863509
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.89957376
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88403169
36GBX2_23144817_ChIP-Seq_PC3_Human1.87906553
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86101862
38DCP1A_22483619_ChIP-Seq_HELA_Human1.84752709
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84747771
40VDR_22108803_ChIP-Seq_LS180_Human1.80066162
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77131187
42P300_19829295_ChIP-Seq_ESCs_Human1.76775390
43* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.74904361
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67824593
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60191993
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59314197
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57498997
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54288993
49* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53709065
50TFEB_21752829_ChIP-Seq_HELA_Human1.51085589
51RXR_22158963_ChIP-Seq_LIVER_Mouse1.49507690
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49125020
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48817518
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45055764
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43885042
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42223073
57MYC_18940864_ChIP-ChIP_HL60_Human1.37890801
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37318828
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.36353434
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35938292
61FOXP3_21729870_ChIP-Seq_TREG_Human1.34302247
62* GABP_19822575_ChIP-Seq_HepG2_Human1.33970544
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.33011308
64ER_23166858_ChIP-Seq_MCF-7_Human1.32489508
65REST_19997604_ChIP-ChIP_NEURONS_Mouse1.27051446
66* SOX17_20123909_ChIP-Seq_XEN_Mouse1.26798419
67* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.26132442
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.25714328
69* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24028935
70LXR_22158963_ChIP-Seq_LIVER_Mouse1.23323420
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21506097
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21046104
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.20551990
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.19962383
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18778149
76CBP_20019798_ChIP-Seq_JUKART_Human1.18778149
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18476227
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18207021
79NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17381802
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17185251
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17083569
82NANOG_19829295_ChIP-Seq_ESCs_Human1.15653915
83SOX2_19829295_ChIP-Seq_ESCs_Human1.15653915
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14848321
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13516056
86ERG_20517297_ChIP-Seq_VCAP_Human1.12505883
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12386196
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11119062
89* SMAD4_21799915_ChIP-Seq_A2780_Human1.11045428
90HTT_18923047_ChIP-ChIP_STHdh_Human1.11045408
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.11003633
92AR_20517297_ChIP-Seq_VCAP_Human1.10630206
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.09813397
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08520544
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08066064
96* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07188440
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06977162
98CDX2_22108803_ChIP-Seq_LS180_Human1.06251985
99PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06146560
100SOX2_20726797_ChIP-Seq_SW620_Human1.06019806
101IRF1_19129219_ChIP-ChIP_H3396_Human1.05094950
102P53_22387025_ChIP-Seq_ESCs_Mouse1.04483957
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04041739
104AR_25329375_ChIP-Seq_VCAP_Human1.03646918
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03296687
106E2F7_22180533_ChIP-Seq_HELA_Human1.03205258
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03055422
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02765731
109NANOG_16153702_ChIP-ChIP_HESCs_Human1.01677190
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01529177
111TP53_22573176_ChIP-Seq_HFKS_Human1.01506320
112BCAT_22108803_ChIP-Seq_LS180_Human1.00364643
113STAT3_23295773_ChIP-Seq_U87_Human1.00360836
114E2F1_18555785_Chip-Seq_ESCs_Mouse0.99995704
115TRIM28_21343339_ChIP-Seq_HEK293_Human0.99805689
116* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99107132
117CMYC_18555785_Chip-Seq_ESCs_Mouse0.98734415
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98637174
119TCF4_22108803_ChIP-Seq_LS180_Human0.98307311
120TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98177407
121ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97541451
122STAT3_18555785_Chip-Seq_ESCs_Mouse0.97280122
123P300_18555785_Chip-Seq_ESCs_Mouse0.97172962
124* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96578482
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95511038
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93778426
127CLOCK_20551151_ChIP-Seq_293T_Human0.93561987
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92418142
129GATA3_26560356_Chip-Seq_TH2_Human0.92008695
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.91519910
131FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90649734
132NMYC_18555785_Chip-Seq_ESCs_Mouse0.88928418
133FUS_26573619_Chip-Seq_HEK293_Human0.88097108
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87503223
135FOXA1_25329375_ChIP-Seq_VCAP_Human0.87411069
136FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87411069
137MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86700554
138CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86165760
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86089307
140NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86089307
141GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86028490
142SMAD1_18555785_Chip-Seq_ESCs_Mouse0.83868544
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83794871
144* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83641983
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83518843
146MYC_19030024_ChIP-ChIP_MESCs_Mouse0.83009258
147NANOG_18555785_Chip-Seq_ESCs_Mouse0.79790521
148TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79762987
149SOX2_18555785_Chip-Seq_ESCs_Mouse0.79734645
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79355681
151SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78959037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.13957119
2MP0003183_abnormal_peptide_metabolism4.10059613
3MP0000013_abnormal_adipose_tissue4.09521864
4MP0005379_endocrine/exocrine_gland_phen3.98136473
5MP0002877_abnormal_melanocyte_morpholog3.66227238
6MP0010386_abnormal_urinary_bladder3.53789898
7MP0002693_abnormal_pancreas_physiology3.48413009
8MP0004043_abnormal_pH_regulation3.44954737
9MP0001944_abnormal_pancreas_morphology3.03455702
10MP0005220_abnormal_exocrine_pancreas2.99776197
11MP0002139_abnormal_hepatobiliary_system2.95498134
12MP0008877_abnormal_DNA_methylation2.84231256
13MP0002837_dystrophic_cardiac_calcinosis2.79932293
14MP0009780_abnormal_chondrocyte_physiolo2.79875731
15MP0005365_abnormal_bile_salt2.78309921
16MP0002102_abnormal_ear_morphology2.62822836
17MP0003121_genomic_imprinting2.44656028
18MP0008058_abnormal_DNA_repair2.44398134
19MP0004147_increased_porphyrin_level2.31355110
20MP0008057_abnormal_DNA_replication2.29788899
21MP0003283_abnormal_digestive_organ2.26153666
22MP0002876_abnormal_thyroid_physiology2.25296188
23MP0003806_abnormal_nucleotide_metabolis2.24868224
24MP0004264_abnormal_extraembryonic_tissu2.09360106
25MP0002909_abnormal_adrenal_gland2.09004842
26MP0002163_abnormal_gland_morphology2.04741539
27MP0003787_abnormal_imprinting1.99530023
28MP0005058_abnormal_lysosome_morphology1.95782682
29MP0000678_abnormal_parathyroid_gland1.95325006
30MP0002078_abnormal_glucose_homeostasis1.92398916
31MP0006054_spinal_hemorrhage1.92252543
32MP0003718_maternal_effect1.90445316
33MP0010094_abnormal_chromosome_stability1.89300819
34MP0005646_abnormal_pituitary_gland1.87274514
35MP0005084_abnormal_gallbladder_morpholo1.81838331
36MP0006292_abnormal_olfactory_placode1.81569502
37MP0002638_abnormal_pupillary_reflex1.80854462
38MP0005408_hypopigmentation1.77564223
39MP0001764_abnormal_homeostasis1.73891532
40MP0005085_abnormal_gallbladder_physiolo1.72541415
41MP0004957_abnormal_blastocyst_morpholog1.70350428
42MP0005551_abnormal_eye_electrophysiolog1.68102565
43MP0001666_abnormal_nutrient_absorption1.64722685
44MP0001986_abnormal_taste_sensitivity1.61812930
45MP0003786_premature_aging1.61756745
46MP0000427_abnormal_hair_cycle1.61135469
47MP0003941_abnormal_skin_development1.59260835
48MP0005253_abnormal_eye_physiology1.58727137
49MP0006072_abnormal_retinal_apoptosis1.56376547
50MP0003950_abnormal_plasma_membrane1.52175699
51MP0005636_abnormal_mineral_homeostasis1.50436490
52MP0009643_abnormal_urine_homeostasis1.46833621
53MP0001984_abnormal_olfaction1.44960788
54MP0009046_muscle_twitch1.42703735
55MP0003172_abnormal_lysosome_physiology1.42675391
56MP0000003_abnormal_adipose_tissue1.42670155
57MP0008932_abnormal_embryonic_tissue1.40224253
58MP0004215_abnormal_myocardial_fiber1.40131803
59MP0003693_abnormal_embryo_hatching1.39166300
60MP0005645_abnormal_hypothalamus_physiol1.39007290
61MP0005083_abnormal_biliary_tract1.38786601
62MP0002138_abnormal_hepatobiliary_system1.38482612
63MP0009697_abnormal_copulation1.38145447
64MP0000569_abnormal_digit_pigmentation1.38111468
65MP0004142_abnormal_muscle_tone1.36082497
66MP0003868_abnormal_feces_composition1.35337857
67MP0002896_abnormal_bone_mineralization1.34941861
68MP0001293_anophthalmia1.34939417
69MP0000613_abnormal_salivary_gland1.32552311
70MP0003959_abnormal_lean_body1.26647335
71MP0003937_abnormal_limbs/digits/tail_de1.26255692
72MP0000372_irregular_coat_pigmentation1.26133220
73MP0003122_maternal_imprinting1.25203854
74MP0004782_abnormal_surfactant_physiolog1.24722571
75MP0002160_abnormal_reproductive_system1.24523768
76MP0003252_abnormal_bile_duct1.23302389
77MP0006276_abnormal_autonomic_nervous1.22730641
78MP0003567_abnormal_fetal_cardiomyocyte1.22625032
79MP0008875_abnormal_xenobiotic_pharmacok1.21786513
80MP0008789_abnormal_olfactory_epithelium1.21092202
81MP0002234_abnormal_pharynx_morphology1.20322145
82MP0001765_abnormal_ion_homeostasis1.18125160
83MP0000647_abnormal_sebaceous_gland1.15397945
84MP0003880_abnormal_central_pattern1.13432376
85MP0001756_abnormal_urination1.08161329
86MP0005332_abnormal_amino_acid1.07607011
87MP0002938_white_spotting1.07069841
88MP0008007_abnormal_cellular_replicative1.05215199
89MP0003724_increased_susceptibility_to1.04316296
90MP0006035_abnormal_mitochondrial_morpho1.03408821
91MP0003953_abnormal_hormone_level1.02592485
92MP0000681_abnormal_thyroid_gland1.01858952
93MP0002751_abnormal_autonomic_nervous1.00067264
94MP0001542_abnormal_bone_strength0.98915772
95MP0005535_abnormal_body_temperature0.98586103
96MP0009384_cardiac_valve_regurgitation0.98226077
97MP0000538_abnormal_urinary_bladder0.97565314
98MP0005171_absent_coat_pigmentation0.96972888
99MP0002233_abnormal_nose_morphology0.96405753
100MP0005360_urolithiasis0.96129766
101MP0001929_abnormal_gametogenesis0.95590375
102MP0004133_heterotaxia0.94166665
103MP0005389_reproductive_system_phenotype0.93446998
104MP0000639_abnormal_adrenal_gland0.93188055
105MP0001661_extended_life_span0.93090650
106MP0000358_abnormal_cell_content/0.91581128
107MP0002118_abnormal_lipid_homeostasis0.90001469
108MP0005410_abnormal_fertilization0.89734066
109MP0005310_abnormal_salivary_gland0.89708326
110MP0003011_delayed_dark_adaptation0.89592237
111MP0001286_abnormal_eye_development0.89229069
112MP0003111_abnormal_nucleus_morphology0.88141711
113MP0005391_vision/eye_phenotype0.87481187
114MP0003795_abnormal_bone_structure0.87424638
115MP0003186_abnormal_redox_activity0.86419153
116MP0002928_abnormal_bile_duct0.85488109
117MP0000653_abnormal_sex_gland0.83849360
118MP0001188_hyperpigmentation0.83038610
119MP0008438_abnormal_cutaneous_collagen0.82552319
120MP0002210_abnormal_sex_determination0.82056495
121MP0000230_abnormal_systemic_arterial0.80553578
122MP0005195_abnormal_posterior_eye0.79964051
123MP0000609_abnormal_liver_physiology0.78202672
124MP0008995_early_reproductive_senescence0.78017691
125MP0002295_abnormal_pulmonary_circulatio0.77322698
126MP0001145_abnormal_male_reproductive0.76538026
127MP0003077_abnormal_cell_cycle0.76073800
128MP0003137_abnormal_impulse_conducting0.75361838
129MP0001299_abnormal_eye_distance/0.75199084
130MP0001324_abnormal_eye_pigmentation0.75159210
131MP0005075_abnormal_melanosome_morpholog0.73658490
132MP0010329_abnormal_lipoprotein_level0.73596340
133MP0005499_abnormal_olfactory_system0.72034249
134MP0005394_taste/olfaction_phenotype0.72034249
135MP0000631_abnormal_neuroendocrine_gland0.71572172
136MP0005448_abnormal_energy_balance0.71033184
137MP0003300_gastrointestinal_ulcer0.70898633
138MP0006036_abnormal_mitochondrial_physio0.69732648
139MP0009642_abnormal_blood_homeostasis0.69471417
140MP0000163_abnormal_cartilage_morphology0.66362178
141MP0005376_homeostasis/metabolism_phenot0.65823774
142MP0001270_distended_abdomen0.64730410
143MP0000462_abnormal_digestive_system0.64197626
144MP0005319_abnormal_enzyme/_coenzyme0.62486532
145MP0002933_joint_inflammation0.61756703
146MP0003123_paternal_imprinting0.61355326
147MP0008469_abnormal_protein_level0.60599045
148MP0002090_abnormal_vision0.56762398
149MP0004019_abnormal_vitamin_homeostasis0.56133047
150MP0001502_abnormal_circadian_rhythm0.55524117
151MP0001529_abnormal_vocalization0.54011404
152MP0002168_other_aberrant_phenotype0.53749988
153MP0001919_abnormal_reproductive_system0.53418030
154MP0003890_abnormal_embryonic-extraembry0.51673353
155MP0000598_abnormal_liver_morphology0.50775707
156MP0001533_abnormal_skeleton_physiology0.50379407
157MP0002009_preneoplasia0.49037303
158MP0005671_abnormal_response_to0.48275192
159MP0001186_pigmentation_phenotype0.48002016

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.72728663
2Hypoglycemic seizures (HP:0002173)5.52792291
3Hypoglycemic coma (HP:0001325)5.37198415
4Symptomatic seizures (HP:0011145)5.23731107
5Abnormality of the intrinsic pathway (HP:0010989)4.17878614
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.99492200
7Generalized aminoaciduria (HP:0002909)3.88282612
8Hyperglycemia (HP:0003074)3.78643642
9Pancreatic islet-cell hyperplasia (HP:0004510)3.74595586
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.52927192
11Abnormality of the pancreatic islet cells (HP:0006476)3.43013094
12Abnormality of endocrine pancreas physiology (HP:0012093)3.43013094
13Type I transferrin isoform profile (HP:0003642)3.33938241
14Hypothermia (HP:0002045)3.28529912
15Vacuolated lymphocytes (HP:0001922)3.28386202
16Insulin-resistant diabetes mellitus (HP:0000831)3.25032891
17Ketoacidosis (HP:0001993)3.22855895
18Abnormal glycosylation (HP:0012345)3.16206245
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.16206245
20Abnormal protein N-linked glycosylation (HP:0012347)3.16206245
21Abnormal protein glycosylation (HP:0012346)3.16206245
22Increased hepatocellular lipid droplets (HP:0006565)3.15801141
23Abnormality of calcium-phosphate metabolism (HP:0100530)3.15343018
24Cervical subluxation (HP:0003308)3.11195245
25Methylmalonic acidemia (HP:0002912)3.00634017
26Late onset (HP:0003584)2.97666446
27Mucopolysacchariduria (HP:0008155)2.92895803
28Urinary glycosaminoglycan excretion (HP:0003541)2.92895803
29Lipid accumulation in hepatocytes (HP:0006561)2.92895016
30Pancreatic cysts (HP:0001737)2.87716636
31Pancreatic fibrosis (HP:0100732)2.87284346
32True hermaphroditism (HP:0010459)2.84141641
33Increased serum pyruvate (HP:0003542)2.82169591
34Beaking of vertebral bodies (HP:0004568)2.81810472
35Abnormality of methionine metabolism (HP:0010901)2.80274346
36Molar tooth sign on MRI (HP:0002419)2.79338314
37Abnormality of midbrain morphology (HP:0002418)2.79338314
38Acute necrotizing encephalopathy (HP:0006965)2.78847327
39Abnormal mitochondria in muscle tissue (HP:0008316)2.69176228
40Abnormal pancreas size (HP:0012094)2.65120331
41Abnormality of the common coagulation pathway (HP:0010990)2.64715782
42Nephronophthisis (HP:0000090)2.63660389
43Osteomalacia (HP:0002749)2.62962658
44Intrahepatic cholestasis (HP:0001406)2.62814836
45Progressive neurologic deterioration (HP:0002344)2.62773731
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60762975
47Dysostosis multiplex (HP:0000943)2.60222768
48Conjugated hyperbilirubinemia (HP:0002908)2.58260957
49Prolonged partial thromboplastin time (HP:0003645)2.57501584
50Acute encephalopathy (HP:0006846)2.57405873
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57162111
52Abnormality of alanine metabolism (HP:0010916)2.57162111
53Hyperalaninemia (HP:0003348)2.57162111
54Large for gestational age (HP:0001520)2.56925124
55Hepatic necrosis (HP:0002605)2.56859791
56Intestinal atresia (HP:0011100)2.52559218
57Abnormality of the renal cortex (HP:0011035)2.51769499
58Disproportionate short-trunk short stature (HP:0003521)2.47455252
59Increased serum lactate (HP:0002151)2.44689427
60Delayed epiphyseal ossification (HP:0002663)2.43666517
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.41715970
62Abnormality of polysaccharide metabolism (HP:0011012)2.41715970
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.41715970
64Type II lissencephaly (HP:0007260)2.41665184
65Flared iliac wings (HP:0002869)2.34986214
66Abnormality of the labia minora (HP:0012880)2.33943000
67Abnormality of glycolysis (HP:0004366)2.33581034
68Abnormality of urine glucose concentration (HP:0011016)2.32232392
69Glycosuria (HP:0003076)2.32232392
70Neuroendocrine neoplasm (HP:0100634)2.30315512
71Abnormality of the pons (HP:0007361)2.28572976
72Irregular vertebral endplates (HP:0003301)2.28029949
73Abnormality of the anterior horn cell (HP:0006802)2.27333450
74Degeneration of anterior horn cells (HP:0002398)2.27333450
75Protuberant abdomen (HP:0001538)2.27240248
76Abnormality of the renal medulla (HP:0100957)2.24780878
77Lactic acidosis (HP:0003128)2.24498369
78Reduced antithrombin III activity (HP:0001976)2.23316520
79Hyperphosphaturia (HP:0003109)2.20986496
80Progressive macrocephaly (HP:0004481)2.20768050
81Genital tract atresia (HP:0001827)2.20182192
82Fat malabsorption (HP:0002630)2.18880792
833-Methylglutaconic aciduria (HP:0003535)2.18610976
84Mitochondrial inheritance (HP:0001427)2.17208864
85Respiratory failure (HP:0002878)2.17140753
86Renal Fanconi syndrome (HP:0001994)2.14991869
87Abnormality of serum amino acid levels (HP:0003112)2.14462846
88Hypoplasia of the pons (HP:0012110)2.14386318
89Metaphyseal irregularity (HP:0003025)2.13442963
90Methylmalonic aciduria (HP:0012120)2.12606687
91Decreased circulating renin level (HP:0003351)2.12539415
9211 pairs of ribs (HP:0000878)2.12417614
93CNS demyelination (HP:0007305)2.11993825
94Renal cortical cysts (HP:0000803)2.11153706
95Hyperglycinemia (HP:0002154)2.11075529
96Prominent metopic ridge (HP:0005487)2.10995193
97Broad face (HP:0000283)2.10918698
98Lethargy (HP:0001254)2.09005539
99Cerebellar dysplasia (HP:0007033)2.08843537
100Vaginal atresia (HP:0000148)2.08793611
101Pheochromocytoma (HP:0002666)2.08447921
102Aplasia/Hypoplasia of the tibia (HP:0005772)2.06940195
103Abolished electroretinogram (ERG) (HP:0000550)2.06315580
104Broad alveolar ridges (HP:0000187)2.06073076
105Medial flaring of the eyebrow (HP:0010747)2.04082321
106Retinal atrophy (HP:0001105)2.03398932
107Hypokalemia (HP:0002900)2.03274219
108Chronic hepatic failure (HP:0100626)2.02134157
109Skin nodule (HP:0200036)2.02035558
110Abnormality of vitamin B metabolism (HP:0004340)2.00784413
111Dysautonomia (HP:0002459)2.00122519
112Increased CSF lactate (HP:0002490)1.98845578
113Colon cancer (HP:0003003)1.98216623
114Short tibia (HP:0005736)1.97469185
115Congenital primary aphakia (HP:0007707)1.97346541
116Supernumerary spleens (HP:0009799)1.97254463
117Ketosis (HP:0001946)1.96498039
118Abdominal distention (HP:0003270)1.96060808
119Insulin resistance (HP:0000855)1.94020916
120Hepatocellular necrosis (HP:0001404)1.93497772
121Hypoplasia of the odontoid process (HP:0003311)1.91238969
122Optic disc pallor (HP:0000543)1.90639832
123Hyperparathyroidism (HP:0000843)1.90143746
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.90133879
125Enlarged epiphyses (HP:0010580)1.90051792
126Enlarged kidneys (HP:0000105)1.89314219
127Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88660900
128Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88660900
129Flat capital femoral epiphysis (HP:0003370)1.88338924
130Abnormality of the ileum (HP:0001549)1.88121766
131Abnormality of the vertebral endplates (HP:0005106)1.87161173
132Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86549495
133Acute hepatic failure (HP:0006554)1.86116344
134Elevated alkaline phosphatase (HP:0003155)1.85252221
135Meckel diverticulum (HP:0002245)1.84925209
136Abnormal epiphyseal ossification (HP:0010656)1.84410534
137Proximal tubulopathy (HP:0000114)1.83471024
138Hypoplasia of the fovea (HP:0007750)1.83299163
139Aplasia/Hypoplasia of the fovea (HP:0008060)1.83299163
140Abnormality of chromosome stability (HP:0003220)1.82711233
141Gait imbalance (HP:0002141)1.82441571
142Hypobetalipoproteinemia (HP:0003563)1.82362904
143Cerebral edema (HP:0002181)1.81401374
144Bifid tongue (HP:0010297)1.80023120
145Abnormality of renal resorption (HP:0011038)1.78859578
146Abnormal urine phosphate concentration (HP:0012599)1.78751422
147Neoplasm of the adrenal gland (HP:0100631)1.78459220
148Irregular epiphyses (HP:0010582)1.78085316
149Nephrogenic diabetes insipidus (HP:0009806)1.77374674
150Sclerocornea (HP:0000647)1.76776806
151Acanthocytosis (HP:0001927)1.76771819
152Thoracolumbar scoliosis (HP:0002944)1.76458038
153Abnormality of small intestinal villus morphology (HP:0011472)1.76199818
154Rhabdomyosarcoma (HP:0002859)1.75797846
155Postaxial foot polydactyly (HP:0001830)1.74187167
156Bile duct proliferation (HP:0001408)1.73917474
157Abnormal biliary tract physiology (HP:0012439)1.73917474
158Megaloblastic anemia (HP:0001889)1.73621836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.74674301
2PASK3.91507099
3MAPK153.38219980
4FRK3.12704536
5STK162.93893643
6TAOK32.74505428
7EIF2AK32.51911624
8EPHA32.49413501
9MAP4K22.42166924
10TRIM282.26794478
11AKT32.26584825
12FLT32.26121749
13MAP3K122.21737748
14WNK32.17401475
15IRAK32.13205583
16MAP3K41.95131795
17IRAK41.89066720
18BCKDK1.87829578
19PIK3CG1.86641964
20BRSK21.73169475
21WNK41.72529756
22MAP3K21.71307947
23IRAK11.67673176
24MST41.65598455
25PLK41.65534229
26HIPK21.52163461
27MKNK21.48974990
28PRKD31.48286949
29BCR1.47405850
30CAMKK21.44849805
31ERN11.41401487
32NME11.40930596
33CASK1.34853349
34FGFR41.34769678
35NEK11.34298335
36CSNK1G11.32869723
37BUB11.30028744
38MKNK11.29695390
39MET1.29304798
40BMPR21.27712598
41GRK11.24851651
42MAP2K71.21793647
43TEC1.20065861
44ERBB31.19852632
45STK38L1.19260475
46ARAF1.19048725
47BRAF1.17266610
48GRK71.16238955
49FGFR21.15383676
50CSNK1G31.14422863
51TTK1.14286285
52WEE11.07290423
53CDC71.06182578
54CSNK1G21.04200567
55NLK1.02875634
56PLK11.02747321
57PNCK0.96250131
58STK390.96086961
59STK30.95759557
60CSNK1A1L0.95151449
61TESK10.93514745
62MAP3K30.92903311
63EIF2AK10.88950420
64DYRK30.86921015
65JAK30.86641722
66VRK10.84201286
67RPS6KA40.82898032
68PAK30.80064873
69MAP3K140.79117892
70OXSR10.78907229
71UHMK10.77691158
72ADRBK20.76334509
73ACVR1B0.75952849
74TSSK60.74170414
75VRK20.73699913
76PRKCE0.70684016
77PBK0.70295970
78PINK10.68259635
79ZAK0.66576764
80ITK0.65821402
81TGFBR20.64899059
82ATM0.64703829
83CDC42BPA0.63738649
84SCYL20.63241025
85NTRK10.63209058
86BMPR1B0.61378431
87MAP3K50.60400108
88PDK30.58395441
89PDK40.58395441
90MOS0.58255706
91DYRK20.58105967
92IGF1R0.57248435
93GRK50.57048179
94BRD40.56693273
95FGFR10.56072638
96ATR0.54292552
97NUAK10.54220036
98NEK60.53370095
99PLK30.53075307
100CDK30.51490045
101TYK20.50513792
102NME20.50410457
103ERBB40.50101453
104EIF2AK20.49491945
105CSNK1E0.49393596
106PRKCG0.49055542
107FER0.48919051
108CSNK2A20.48389967
109PDK20.48379590
110MYLK0.47656868
111JAK10.46685970
112RPS6KB10.45892174
113YES10.45638563
114AURKB0.44362197
115MAP2K40.44277137
116CCNB10.44220722
117PLK20.43863235
118PIK3CA0.43432818
119PDGFRA0.43240217
120PTK20.43027833
121JAK20.42958669
122LIMK10.41888942
123CDK80.41321014
124SRPK10.40739694
125IKBKE0.40020201
126CHUK0.38839289
127EPHA40.38681244
128EPHA20.38400797
129OBSCN0.38395216
130TBK10.38102859
131TNIK0.38027627
132TAF10.37395696
133TGFBR10.37183542
134PRKCI0.36629981
135CSNK1A10.36456851
136DYRK1B0.36426360
137NEK90.35658145
138CDK190.35375146
139RPS6KA50.34733355
140PHKG10.34433128
141PHKG20.34433128
142MINK10.34230898
143IRAK20.34099742
144EPHB10.33387053
145ZAP700.33072550
146FGFR30.32983388
147ADRBK10.31991434
148PRKCQ0.31093842
149PRKCH0.30478395
150CAMK2D0.30221251
151CSNK2A10.29287202
152MAPK130.29219706

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030607.45170691
2Maturity onset diabetes of the young_Homo sapiens_hsa049506.65424084
3Sulfur metabolism_Homo sapiens_hsa009203.46564581
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.16287496
5Proteasome_Homo sapiens_hsa030502.26861250
6Mismatch repair_Homo sapiens_hsa034302.07941089
7Homologous recombination_Homo sapiens_hsa034402.03407178
8Vibrio cholerae infection_Homo sapiens_hsa051102.01323009
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00067216
10N-Glycan biosynthesis_Homo sapiens_hsa005101.93119475
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85823347
12Selenocompound metabolism_Homo sapiens_hsa004501.85772401
13Other glycan degradation_Homo sapiens_hsa005111.85523136
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79478440
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.78776928
16Fanconi anemia pathway_Homo sapiens_hsa034601.76047314
17Folate biosynthesis_Homo sapiens_hsa007901.73536693
18Type I diabetes mellitus_Homo sapiens_hsa049401.70620936
19Nucleotide excision repair_Homo sapiens_hsa034201.70422683
20Oxidative phosphorylation_Homo sapiens_hsa001901.57234724
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.55493242
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54546389
23Fatty acid elongation_Homo sapiens_hsa000621.54394362
24Lysosome_Homo sapiens_hsa041421.41943607
25RNA transport_Homo sapiens_hsa030131.36887876
26DNA replication_Homo sapiens_hsa030301.33358175
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32495511
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29903808
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28007601
30Steroid biosynthesis_Homo sapiens_hsa001001.24367677
31Tryptophan metabolism_Homo sapiens_hsa003801.23821185
32Regulation of autophagy_Homo sapiens_hsa041401.19576161
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17823098
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.15212888
35Insulin secretion_Homo sapiens_hsa049111.14183892
36Sphingolipid metabolism_Homo sapiens_hsa006001.11816857
37Peroxisome_Homo sapiens_hsa041461.10271606
38Spliceosome_Homo sapiens_hsa030401.08259224
39Parkinsons disease_Homo sapiens_hsa050121.07923522
40Galactose metabolism_Homo sapiens_hsa000521.06726403
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.05427234
42Nitrogen metabolism_Homo sapiens_hsa009101.05268595
43Phototransduction_Homo sapiens_hsa047441.01060125
44Linoleic acid metabolism_Homo sapiens_hsa005910.92932553
45Butanoate metabolism_Homo sapiens_hsa006500.90203010
46Histidine metabolism_Homo sapiens_hsa003400.89127705
47Antigen processing and presentation_Homo sapiens_hsa046120.85812612
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85181550
49Collecting duct acid secretion_Homo sapiens_hsa049660.84977231
50Starch and sucrose metabolism_Homo sapiens_hsa005000.84290575
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.83436527
52Alzheimers disease_Homo sapiens_hsa050100.82293705
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81872719
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81690396
55Base excision repair_Homo sapiens_hsa034100.79612753
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78843003
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78649372
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78587083
59Fatty acid degradation_Homo sapiens_hsa000710.78186756
60Vitamin B6 metabolism_Homo sapiens_hsa007500.77702193
61Fat digestion and absorption_Homo sapiens_hsa049750.77337220
62RNA polymerase_Homo sapiens_hsa030200.77167158
63Pyruvate metabolism_Homo sapiens_hsa006200.75841088
64beta-Alanine metabolism_Homo sapiens_hsa004100.75535090
65Tyrosine metabolism_Homo sapiens_hsa003500.74748200
66Circadian rhythm_Homo sapiens_hsa047100.74731550
67Phagosome_Homo sapiens_hsa041450.72580420
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71405433
69Cardiac muscle contraction_Homo sapiens_hsa042600.69405611
70One carbon pool by folate_Homo sapiens_hsa006700.68930613
71Metabolic pathways_Homo sapiens_hsa011000.68661804
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68215335
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65427844
74Phenylalanine metabolism_Homo sapiens_hsa003600.65153393
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64637442
76Propanoate metabolism_Homo sapiens_hsa006400.61481167
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61327321
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61217211
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60901931
80ABC transporters_Homo sapiens_hsa020100.60805351
81Fatty acid metabolism_Homo sapiens_hsa012120.60309387
82Carbon metabolism_Homo sapiens_hsa012000.59669057
83Ether lipid metabolism_Homo sapiens_hsa005650.56529818
84Arachidonic acid metabolism_Homo sapiens_hsa005900.55110577
85Huntingtons disease_Homo sapiens_hsa050160.54854198
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54579435
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54486581
88Cell cycle_Homo sapiens_hsa041100.54076466
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54074091
90Arginine and proline metabolism_Homo sapiens_hsa003300.53885020
91RNA degradation_Homo sapiens_hsa030180.53132615
92Legionellosis_Homo sapiens_hsa051340.53126113
93Caffeine metabolism_Homo sapiens_hsa002320.52853639
94Pyrimidine metabolism_Homo sapiens_hsa002400.50881115
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49701315
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.49215747
97Rheumatoid arthritis_Homo sapiens_hsa053230.48648770
98Fructose and mannose metabolism_Homo sapiens_hsa000510.47030342
99p53 signaling pathway_Homo sapiens_hsa041150.44693866
100Non-homologous end-joining_Homo sapiens_hsa034500.44307142
101Chemical carcinogenesis_Homo sapiens_hsa052040.43807141
102Renin-angiotensin system_Homo sapiens_hsa046140.43378336
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42694718
104Complement and coagulation cascades_Homo sapiens_hsa046100.41580109
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40487807
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39267422
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38721824
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38543565
109Fatty acid biosynthesis_Homo sapiens_hsa000610.37943216
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37774341
111Ribosome_Homo sapiens_hsa030100.37476547
112Oocyte meiosis_Homo sapiens_hsa041140.36843163
113Prion diseases_Homo sapiens_hsa050200.36005733
114Basal transcription factors_Homo sapiens_hsa030220.34927010
115mRNA surveillance pathway_Homo sapiens_hsa030150.34679482
116Glutathione metabolism_Homo sapiens_hsa004800.33380719
117Protein digestion and absorption_Homo sapiens_hsa049740.33092020
118Pancreatic secretion_Homo sapiens_hsa049720.30763513
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29771223
120Purine metabolism_Homo sapiens_hsa002300.27650388
121Vitamin digestion and absorption_Homo sapiens_hsa049770.27547581
122Thyroid hormone synthesis_Homo sapiens_hsa049180.25329747
123Type II diabetes mellitus_Homo sapiens_hsa049300.23749293
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23435747
125Glucagon signaling pathway_Homo sapiens_hsa049220.23124107
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22216484
127Cocaine addiction_Homo sapiens_hsa050300.21146428
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.15812869
129Retinol metabolism_Homo sapiens_hsa008300.15637749

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