SCCPDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)6.71906291
2glyoxylate metabolic process (GO:0046487)6.24274895
3long-chain fatty acid biosynthetic process (GO:0042759)5.50687812
4myelination (GO:0042552)5.49747285
5ensheathment of neurons (GO:0007272)5.46970223
6axon ensheathment (GO:0008366)5.46970223
7polyketide metabolic process (GO:0030638)5.26026567
8doxorubicin metabolic process (GO:0044598)5.26026567
9daunorubicin metabolic process (GO:0044597)5.26026567
10L-phenylalanine catabolic process (GO:0006559)5.12793620
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.12793620
12L-phenylalanine metabolic process (GO:0006558)5.02047424
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.02047424
14myelin maintenance (GO:0043217)4.76985870
15negative regulation of neurotransmitter transport (GO:0051589)4.75724170
16aminoglycoside antibiotic metabolic process (GO:0030647)4.69917959
17exogenous drug catabolic process (GO:0042738)4.58943533
18urea metabolic process (GO:0019627)4.52816517
19establishment of mitochondrion localization (GO:0051654)4.49105198
20drug catabolic process (GO:0042737)4.43344881
21negative regulation of neurotransmitter secretion (GO:0046929)4.37120018
22response to methylmercury (GO:0051597)4.29888706
23nitrogen cycle metabolic process (GO:0071941)4.27493776
24bile acid biosynthetic process (GO:0006699)4.27276791
25epoxygenase P450 pathway (GO:0019373)4.26007697
26acrosome reaction (GO:0007340)4.24491123
27negative regulation of fibrinolysis (GO:0051918)4.23556748
28cellular glucuronidation (GO:0052695)4.14283953
29negative regulation of protein localization to cell surface (GO:2000009)4.12616017
30regulation of protein activation cascade (GO:2000257)4.12284855
31regulation of fibrinolysis (GO:0051917)4.10321689
32cholesterol biosynthetic process (GO:0006695)4.09395023
33uronic acid metabolic process (GO:0006063)4.07771957
34glucuronate metabolic process (GO:0019585)4.07771957
35ethanol oxidation (GO:0006069)4.06553400
36complement activation, alternative pathway (GO:0006957)4.05743952
37urea cycle (GO:0000050)4.02437355
38cilium or flagellum-dependent cell motility (GO:0001539)3.94062506
39eye photoreceptor cell differentiation (GO:0001754)3.85978580
40photoreceptor cell differentiation (GO:0046530)3.85978580
41omega-hydroxylase P450 pathway (GO:0097267)3.83112636
42regulation of complement activation (GO:0030449)3.82438364
43regulation of collateral sprouting (GO:0048670)3.79707344
44amino-acid betaine metabolic process (GO:0006577)3.77832149
45bile acid metabolic process (GO:0008206)3.76279076
46sterol biosynthetic process (GO:0016126)3.72879359
47presynaptic membrane organization (GO:0097090)3.70618900
48blood coagulation, intrinsic pathway (GO:0007597)3.70352542
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.69463662
50fibrinolysis (GO:0042730)3.67531940
51aldehyde catabolic process (GO:0046185)3.67117435
52peptidyl-glutamic acid carboxylation (GO:0017187)3.61909098
53protein carboxylation (GO:0018214)3.61909098
54drug metabolic process (GO:0017144)3.56584282
55regulation of cholesterol esterification (GO:0010872)3.54614733
56L-amino acid import (GO:0043092)3.54115981
57very-low-density lipoprotein particle assembly (GO:0034379)3.53902359
58primary alcohol catabolic process (GO:0034310)3.53717458
59quinone metabolic process (GO:1901661)3.52681218
60carnitine metabolic process (GO:0009437)3.51882067
61substantia nigra development (GO:0021762)3.51674115
62oxidative demethylation (GO:0070989)3.50448818
63apical protein localization (GO:0045176)3.45184423
64serine family amino acid catabolic process (GO:0009071)3.44842398
65ethanol metabolic process (GO:0006067)3.44636661
66oligodendrocyte differentiation (GO:0048709)3.43995235
67astrocyte development (GO:0014002)3.43113586
68negative regulation of inclusion body assembly (GO:0090084)3.41131827
69asymmetric protein localization (GO:0008105)3.39079110
70long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.37561520
71fusion of sperm to egg plasma membrane (GO:0007342)3.34999327
72long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.33480137
73glycine metabolic process (GO:0006544)3.33472483
74glycerophospholipid catabolic process (GO:0046475)3.33251774
75axonemal dynein complex assembly (GO:0070286)3.32167154
76positive regulation of triglyceride lipase activity (GO:0061365)3.31157657
77positive regulation of lipoprotein lipase activity (GO:0051006)3.31157657
78positive regulation of oligodendrocyte differentiation (GO:0048714)3.31142870
79glycoside metabolic process (GO:0016137)3.29453847
80isoprenoid biosynthetic process (GO:0008299)3.28959221
81deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.28703211
82sperm capacitation (GO:0048240)3.28656516
83fatty acid beta-oxidation (GO:0006635)3.27465575
84sperm motility (GO:0030317)3.25630400
85amyloid precursor protein metabolic process (GO:0042982)3.24575950
86creatine metabolic process (GO:0006600)3.23022291
87aromatic amino acid family catabolic process (GO:0009074)3.22845350
88xenobiotic catabolic process (GO:0042178)3.22651657
89response to redox state (GO:0051775)3.19879876
90epithelial cilium movement (GO:0003351)3.19500848
91fat-soluble vitamin biosynthetic process (GO:0042362)3.18371609
92fatty acid catabolic process (GO:0009062)3.16504281
93negative regulation of sterol transport (GO:0032372)3.16502932
94negative regulation of cholesterol transport (GO:0032375)3.16502932
95cellular aldehyde metabolic process (GO:0006081)3.16364066
96presynaptic membrane assembly (GO:0097105)3.15699561
97neuron cell-cell adhesion (GO:0007158)3.11897050
98serine family amino acid metabolic process (GO:0009069)3.11214979
99oxidative phosphorylation (GO:0006119)3.09981020
100monocarboxylic acid catabolic process (GO:0072329)3.09656079
101adult walking behavior (GO:0007628)3.05505609
1022-deoxyribonucleotide biosynthetic process (GO:0009265)3.04824010
103deoxyribose phosphate biosynthetic process (GO:0046385)3.04824010
104alpha-linolenic acid metabolic process (GO:0036109)3.04735283
105arginine metabolic process (GO:0006525)3.02634997
106regulation of lipoprotein metabolic process (GO:0050746)3.01239815
107cerebral cortex radially oriented cell migration (GO:0021799)3.01200260
108multicellular organism reproduction (GO:0032504)2.96777906
109neurotransmitter uptake (GO:0001504)2.96760254
110neuronal action potential propagation (GO:0019227)2.95619462
111fatty acid oxidation (GO:0019395)2.95252418
112phenylpropanoid metabolic process (GO:0009698)2.93696855
113cilium movement (GO:0003341)2.93357101
114short-chain fatty acid metabolic process (GO:0046459)2.93305593
115NADH metabolic process (GO:0006734)2.92904663
116protein-lipid complex remodeling (GO:0034368)2.92732235
117macromolecular complex remodeling (GO:0034367)2.92732235
118plasma lipoprotein particle remodeling (GO:0034369)2.92732235
119quinone biosynthetic process (GO:1901663)2.92554699
120pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.92179264
121lipid oxidation (GO:0034440)2.91437052
122regulation of plasminogen activation (GO:0010755)2.88446319
123myelination in peripheral nervous system (GO:0022011)2.87922775
124peripheral nervous system axon ensheathment (GO:0032292)2.87922775
125neuron recognition (GO:0008038)2.86814760
126hormone catabolic process (GO:0042447)2.83862813
127piRNA metabolic process (GO:0034587)2.82549113
128phospholipid efflux (GO:0033700)2.82199953
129fatty-acyl-CoA biosynthetic process (GO:0046949)2.81986109
130L-serine metabolic process (GO:0006563)2.81153917
131peroxisome fission (GO:0016559)2.80413834
132cholesterol efflux (GO:0033344)2.78801301
133protein neddylation (GO:0045116)2.77417382
134acrosome assembly (GO:0001675)2.77273313
135arginine catabolic process (GO:0006527)2.77063564
136epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.76048241
137fatty-acyl-CoA metabolic process (GO:0035337)2.74865402
138biotin metabolic process (GO:0006768)2.74709675
139protein polyglutamylation (GO:0018095)2.74308109
140negative regulation of axonogenesis (GO:0050771)2.74028588
141magnesium ion transport (GO:0015693)2.73515245
142protein palmitoylation (GO:0018345)2.73394468
143alpha-amino acid catabolic process (GO:1901606)2.72403443
144serine family amino acid biosynthetic process (GO:0009070)2.72270662
145axon development (GO:0061564)2.71989885
146negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.71495834
147limb bud formation (GO:0060174)2.71182096
148branched-chain amino acid catabolic process (GO:0009083)2.70145663
149protein maturation by protein folding (GO:0022417)2.69637127
150microtubule polymerization or depolymerization (GO:0031109)2.69329610
151negative regulation of hemostasis (GO:1900047)2.69040660
152negative regulation of blood coagulation (GO:0030195)2.69040660
153calcium ion-dependent exocytosis (GO:0017156)2.68769040
154membrane tubulation (GO:0097320)2.68625950
155heme metabolic process (GO:0042168)2.66720908
156pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.66594375
157transmission of nerve impulse (GO:0019226)2.66531158
158amino acid salvage (GO:0043102)2.66230619
159L-methionine salvage (GO:0071267)2.66230619
160L-methionine biosynthetic process (GO:0071265)2.66230619
161axonal fasciculation (GO:0007413)2.66166443
162high-density lipoprotein particle remodeling (GO:0034375)2.65939787
163import into cell (GO:0098657)2.65797023
164imidazole-containing compound metabolic process (GO:0052803)2.65426454
165microtubule severing (GO:0051013)2.64347070
166carboxylic acid catabolic process (GO:0046395)2.63840689
167organic acid catabolic process (GO:0016054)2.63840689
168cofactor catabolic process (GO:0051187)2.62937294
169plasma membrane fusion (GO:0045026)2.62621762
170very long-chain fatty acid metabolic process (GO:0000038)2.61789894
171response to nitrosative stress (GO:0051409)2.57842431
172neuron remodeling (GO:0016322)2.57464840
173amino acid import (GO:0043090)2.57237293
174glutamate metabolic process (GO:0006536)2.56751339
175dendritic spine morphogenesis (GO:0060997)2.55811237
176detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.55772974
177detection of temperature stimulus involved in sensory perception (GO:0050961)2.55772974
178neuronal ion channel clustering (GO:0045161)2.54871706
179response to lipoprotein particle (GO:0055094)2.53216104
180GPI anchor biosynthetic process (GO:0006506)2.51808633
181neural nucleus development (GO:0048857)2.50460837
182mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.49472597
183positive regulation of action potential (GO:0045760)2.48385924
184GPI anchor metabolic process (GO:0006505)2.48192284
185reproduction (GO:0000003)2.47129099
186peptidyl-tyrosine autophosphorylation (GO:0038083)2.45123337
187nerve growth factor signaling pathway (GO:0038180)2.45050306
188sperm-egg recognition (GO:0035036)2.44213400
189regulation of autophagic vacuole assembly (GO:2000785)2.43574283
190cell wall macromolecule metabolic process (GO:0044036)2.42974180
191cell wall macromolecule catabolic process (GO:0016998)2.42974180
192positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.42839243
193regulation of dopamine metabolic process (GO:0042053)2.42675231
194regulation of catecholamine metabolic process (GO:0042069)2.42675231
195peptidyl-cysteine modification (GO:0018198)2.41822295
196regulation of inclusion body assembly (GO:0090083)2.40964626
197regulation of microtubule-based movement (GO:0060632)2.39939121
198peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.39296939
199axon ensheathment in central nervous system (GO:0032291)10.1013230
200central nervous system myelination (GO:0022010)10.1013230

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.51157161
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.75428264
3EZH2_22144423_ChIP-Seq_EOC_Human4.32764662
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71557050
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.23515179
6GBX2_23144817_ChIP-Seq_PC3_Human3.16647367
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05479984
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.02912974
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.00152988
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.98485266
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95393711
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.84618428
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.81075945
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65968852
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.56799527
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42400768
17ZNF263_19887448_ChIP-Seq_K562_Human2.36625187
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32392485
19SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.31563967
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.29003955
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26884012
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25295720
23TAF15_26573619_Chip-Seq_HEK293_Human2.25229271
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24130456
25E2F7_22180533_ChIP-Seq_HELA_Human2.20971793
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18370163
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13329244
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11889721
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10553855
30JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10371095
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.09231241
32* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.06944110
33VDR_22108803_ChIP-Seq_LS180_Human2.06384364
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.99683903
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.99628620
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.99149920
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97847401
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94625857
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93918007
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.91018314
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.90954545
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89102986
43* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88973316
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88638764
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88055930
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84434790
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84309699
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.82905812
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.82407803
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82117280
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.81804306
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81281260
53* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81137223
54* EZH2_27294783_Chip-Seq_ESCs_Mouse1.80908641
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.80616636
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78111290
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77885977
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77885977
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76830759
60ER_23166858_ChIP-Seq_MCF-7_Human1.76346325
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74666832
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72559056
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72128882
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.67657175
65DCP1A_22483619_ChIP-Seq_HELA_Human1.67636110
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65485493
67GABP_19822575_ChIP-Seq_HepG2_Human1.64999223
68REST_21632747_ChIP-Seq_MESCs_Mouse1.61169135
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60348336
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59681765
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58960563
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53045463
73* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53025396
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.52977956
75AR_21572438_ChIP-Seq_LNCaP_Human1.52393876
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49959319
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48309186
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46413980
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45478953
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44286646
81FUS_26573619_Chip-Seq_HEK293_Human1.44037419
82DROSHA_22980978_ChIP-Seq_HELA_Human1.42404921
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41136536
84P300_19829295_ChIP-Seq_ESCs_Human1.40023086
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36230450
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35135019
87IRF1_19129219_ChIP-ChIP_H3396_Human1.34834045
88AR_21909140_ChIP-Seq_LNCAP_Human1.34645942
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33558876
90RNF2_27304074_Chip-Seq_NSC_Mouse1.32440763
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31451552
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30234197
93* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30119097
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28621825
95* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.28262782
96SMAD4_21799915_ChIP-Seq_A2780_Human1.28196480
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26185127
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.26140761
99CLOCK_20551151_ChIP-Seq_293T_Human1.24874339
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.24614325
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24226693
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23414649
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23144481
104IGF1R_20145208_ChIP-Seq_DFB_Human1.22711185
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22374059
106ZNF274_21170338_ChIP-Seq_K562_Hela1.21212600
107TTF2_22483619_ChIP-Seq_HELA_Human1.20632697
108MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20529502
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.20266379
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.20225683
111XRN2_22483619_ChIP-Seq_HELA_Human1.19853614
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19095409
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19076807
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18717722
115STAT3_23295773_ChIP-Seq_U87_Human1.18613013
116REST_18959480_ChIP-ChIP_MESCs_Mouse1.18119388
117* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17922486
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17866188
119GATA1_26923725_Chip-Seq_HPCs_Mouse1.17850189
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17746715
121SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16755183
122* NANOG_18555785_Chip-Seq_ESCs_Mouse1.16644908
123TRIM28_21343339_ChIP-Seq_HEK293_Human1.16039792
124RARB_27405468_Chip-Seq_BRAIN_Mouse1.15872941
125SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15725375
126TCF4_23295773_ChIP-Seq_U87_Human1.14373157
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13247313
128* CMYC_18555785_Chip-Seq_ESCs_Mouse1.12335491
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11574506
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11465667
131STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11428140
132PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11075650
133ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09800285
134ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08658966
135TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08568329
136HTT_18923047_ChIP-ChIP_STHdh_Human1.08355581
137* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07335134
138EST1_17652178_ChIP-ChIP_JURKAT_Human1.06883679
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06550500
140FLI1_27457419_Chip-Seq_LIVER_Mouse1.05444556
141NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05130901
142* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04992764
143CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04731015
144SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04473347
145PRDM14_20953172_ChIP-Seq_ESCs_Human1.04051904
146MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04034126
147KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03980307
148TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03249811
149PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02237243
150CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01970699
151KDM2B_26808549_Chip-Seq_REH_Human1.01939245
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01728923
153* P300_18555785_Chip-Seq_ESCs_Mouse1.01471680
154CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01086058
155YY1_21170310_ChIP-Seq_MESCs_Mouse0.99685737
156LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97271025
157SMAD4_21741376_ChIP-Seq_EPCs_Human0.97244654
158DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96621592
159LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96577585
160* P53_22387025_ChIP-Seq_ESCs_Mouse0.96174941
161NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95746458
162NANOG_19829295_ChIP-Seq_ESCs_Human0.95062622
163SOX2_19829295_ChIP-Seq_ESCs_Human0.95062622
164* E2F1_18555785_Chip-Seq_ESCs_Mouse0.93971972
165P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93951279
166NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93449327
167* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93432819
168* STAT3_18555785_Chip-Seq_ESCs_Mouse0.92854179
169HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92744744
170MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92552844
171PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92395383
172FLI1_21867929_ChIP-Seq_TH2_Mouse0.92198007
173ARNT_22903824_ChIP-Seq_MCF-7_Human0.92166280
174RING1B_27294783_Chip-Seq_ESCs_Mouse0.91419535
175SOX17_20123909_ChIP-Seq_XEN_Mouse0.90946814
176HNF4A_19822575_ChIP-Seq_HepG2_Human0.90259867
177CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89688142
178POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89618750
179VDR_23849224_ChIP-Seq_CD4+_Human0.89187870
180FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88940727
181* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86079512
182ELK1_19687146_ChIP-ChIP_HELA_Human0.85478735
183GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85056585
184PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84405197
185ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81790722
186PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81767727
187YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81457727
188FOXP3_21729870_ChIP-Seq_TREG_Human0.81127849
189POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78572065
190REST_19997604_ChIP-ChIP_NEURONS_Mouse0.77935684
191* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77200060
192HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77190059
193SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75587273
194EOMES_21245162_ChIP-Seq_HESCs_Human0.75224143
195KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72265804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.66655992
2MP0005410_abnormal_fertilization4.34440346
3MP0005360_urolithiasis4.29788442
4MP0008875_abnormal_xenobiotic_pharmacok4.09443099
5MP0000920_abnormal_myelination4.00243367
6MP0005365_abnormal_bile_salt3.99516762
7MP0005085_abnormal_gallbladder_physiolo3.89611415
8MP0003880_abnormal_central_pattern3.77326314
9MP0003950_abnormal_plasma_membrane3.09571790
10MP0004270_analgesia2.98707090
11MP0009697_abnormal_copulation2.90789710
12MP0001529_abnormal_vocalization2.71480911
13MP0001666_abnormal_nutrient_absorption2.64526945
14MP0002272_abnormal_nervous_system2.53333423
15MP0003329_amyloid_beta_deposits2.49015432
16MP0005423_abnormal_somatic_nervous2.43775756
17MP0001486_abnormal_startle_reflex2.33818966
18MP0004859_abnormal_synaptic_plasticity2.32532672
19MP0003806_abnormal_nucleotide_metabolis2.30809857
20MP0004147_increased_porphyrin_level2.29387356
21MP0003868_abnormal_feces_composition2.25838922
22MP0003690_abnormal_glial_cell2.25642783
23MP0003186_abnormal_redox_activity2.23361186
24MP0000778_abnormal_nervous_system2.22983322
25MP0002064_seizures2.19904389
26MP0009046_muscle_twitch2.18631576
27MP0001905_abnormal_dopamine_level2.17208681
28MP0004142_abnormal_muscle_tone2.08790414
29MP0003635_abnormal_synaptic_transmissio2.08371294
30MP0003656_abnormal_erythrocyte_physiolo2.08193589
31MP0009840_abnormal_foam_cell2.06783813
32MP0003252_abnormal_bile_duct2.04718954
33MP0004742_abnormal_vestibular_system2.03188266
34MP0010329_abnormal_lipoprotein_level2.03130412
35MP0005171_absent_coat_pigmentation1.98585891
36MP0003634_abnormal_glial_cell1.97027727
37MP0004885_abnormal_endolymph1.95999225
38MP0002734_abnormal_mechanical_nocicepti1.93887417
39MP0003195_calcinosis1.91279480
40MP0002876_abnormal_thyroid_physiology1.90536543
41MP0009745_abnormal_behavioral_response1.88665307
42MP0005332_abnormal_amino_acid1.87852949
43MP0003136_yellow_coat_color1.86460764
44MP0005058_abnormal_lysosome_morphology1.84116713
45MP0006036_abnormal_mitochondrial_physio1.79181024
46MP0003191_abnormal_cellular_cholesterol1.77354275
47MP0002063_abnormal_learning/memory/cond1.71215652
48MP0001764_abnormal_homeostasis1.70213538
49MP0001485_abnormal_pinna_reflex1.69038452
50MP0002572_abnormal_emotion/affect_behav1.68043110
51MP0002229_neurodegeneration1.63242564
52MP0003698_abnormal_male_reproductive1.59565821
53MP0001440_abnormal_grooming_behavior1.58077944
54MP0005623_abnormal_meninges_morphology1.57634402
55MP0005551_abnormal_eye_electrophysiolog1.56808357
56MP0005084_abnormal_gallbladder_morpholo1.49962668
57MP0000955_abnormal_spinal_cord1.48742215
58MP0004134_abnormal_chest_morphology1.46847167
59MP0005409_darkened_coat_color1.46401621
60MP0003632_abnormal_nervous_system1.46229578
61MP0008789_abnormal_olfactory_epithelium1.45417728
62MP0004043_abnormal_pH_regulation1.43345517
63MP0001970_abnormal_pain_threshold1.43007601
64MP0001968_abnormal_touch/_nociception1.42773823
65MP0002067_abnormal_sensory_capabilities1.42382064
66MP0005584_abnormal_enzyme/coenzyme_acti1.42164794
67MP0002882_abnormal_neuron_morphology1.41398419
68MP0004145_abnormal_muscle_electrophysio1.41320104
69MP0003631_nervous_system_phenotype1.39916795
70MP0002118_abnormal_lipid_homeostasis1.39522142
71MP0008569_lethality_at_weaning1.37981120
72MP0003633_abnormal_nervous_system1.35692356
73MP0002735_abnormal_chemical_nociception1.34638560
74MP0002138_abnormal_hepatobiliary_system1.32572658
75MP0010386_abnormal_urinary_bladder1.32280817
76MP0002733_abnormal_thermal_nociception1.28155768
77MP0006276_abnormal_autonomic_nervous1.27533171
78MP0002736_abnormal_nociception_after1.26328947
79MP0005645_abnormal_hypothalamus_physiol1.26008387
80MP0010368_abnormal_lymphatic_system1.25383521
81MP0005386_behavior/neurological_phenoty1.25328674
82MP0004924_abnormal_behavior1.25328674
83MP0002066_abnormal_motor_capabilities/c1.25238164
84MP0000751_myopathy1.24127451
85MP0005187_abnormal_penis_morphology1.18465596
86MP0000462_abnormal_digestive_system1.17889470
87MP0004036_abnormal_muscle_relaxation1.17007933
88MP0004019_abnormal_vitamin_homeostasis1.16305559
89MP0002752_abnormal_somatic_nervous1.15538018
90MP0000609_abnormal_liver_physiology1.14871527
91MP0005499_abnormal_olfactory_system1.14789507
92MP0005394_taste/olfaction_phenotype1.14789507
93MP0008877_abnormal_DNA_methylation1.11817258
94MP0001963_abnormal_hearing_physiology1.11037234
95MP0002184_abnormal_innervation1.08398847
96MP0009379_abnormal_foot_pigmentation1.07872972
97MP0001299_abnormal_eye_distance/1.07851364
98MP0001929_abnormal_gametogenesis1.07728146
99MP0000747_muscle_weakness1.07541631
100MP0001661_extended_life_span1.07384127
101MP0005408_hypopigmentation1.06026739
102MP0005646_abnormal_pituitary_gland1.01965104
103MP0008260_abnormal_autophagy1.01728453
104MP0003122_maternal_imprinting1.01706886
105MP0006072_abnormal_retinal_apoptosis1.01231139
106MP0000604_amyloidosis1.01158167
107MP0005253_abnormal_eye_physiology1.00092232
108MP0005319_abnormal_enzyme/_coenzyme0.99912155
109MP0005636_abnormal_mineral_homeostasis0.99069730
110MP0010678_abnormal_skin_adnexa0.98637248
111MP0001984_abnormal_olfaction0.98480731
112MP0002557_abnormal_social/conspecific_i0.98238880
113MP0002152_abnormal_brain_morphology0.98163630
114MP0000749_muscle_degeneration0.98020352
115MP0005195_abnormal_posterior_eye0.94837137
116MP0008058_abnormal_DNA_repair0.94436180
117MP0003718_maternal_effect0.94210583
118MP0003137_abnormal_impulse_conducting0.93887520
119MP0002909_abnormal_adrenal_gland0.91970761
120MP0004811_abnormal_neuron_physiology0.90642378
121MP0001501_abnormal_sleep_pattern0.90164633
122MP0001502_abnormal_circadian_rhythm0.86911222
123MP0002160_abnormal_reproductive_system0.86804429
124MP0009643_abnormal_urine_homeostasis0.86797664
125MP0000598_abnormal_liver_morphology0.86661891
126MP0001177_atelectasis0.85703756
127MP0002971_abnormal_brown_adipose0.84635909
128MP0003121_genomic_imprinting0.83956708
129MP0000358_abnormal_cell_content/0.81768889
130MP0005330_cardiomyopathy0.80860735
131MP0000026_abnormal_inner_ear0.80563590
132MP0000639_abnormal_adrenal_gland0.79849792
133MP0000631_abnormal_neuroendocrine_gland0.77379812
134MP0002822_catalepsy0.77072071
135MP0008932_abnormal_embryonic_tissue0.76488851
136MP0003315_abnormal_perineum_morphology0.75853481
137MP0000383_abnormal_hair_follicle0.75453653
138MP0000013_abnormal_adipose_tissue0.74169376
139MP0002161_abnormal_fertility/fecundity0.73969625
140MP0000647_abnormal_sebaceous_gland0.73678826
141MP0000566_synostosis0.73217822
142MP0004858_abnormal_nervous_system0.72640301
143MP0002269_muscular_atrophy0.72245773
144MP0005535_abnormal_body_temperature0.71742871
145MP0006035_abnormal_mitochondrial_morpho0.71553177
146MP0002295_abnormal_pulmonary_circulatio0.71461927
147MP0009780_abnormal_chondrocyte_physiolo0.71319516
148MP0006292_abnormal_olfactory_placode0.70518029
149MP0004782_abnormal_surfactant_physiolog0.68651648
150MP0002102_abnormal_ear_morphology0.66228986
151MP0004133_heterotaxia0.66046077
152MP0003938_abnormal_ear_development0.65224739
153MP0009250_abnormal_appendicular_skeleto0.65016255
154MP0002653_abnormal_ependyma_morphology0.64865445
155MP0004085_abnormal_heartbeat0.64654937
156MP0003937_abnormal_limbs/digits/tail_de0.62896399
157MP0001756_abnormal_urination0.62430769
158MP0001986_abnormal_taste_sensitivity0.61599376
159MP0001943_abnormal_respiration0.60814192
160MP0002090_abnormal_vision0.60762329
161MP0003011_delayed_dark_adaptation0.60653013
162MP0005376_homeostasis/metabolism_phenot0.59758372
163MP0005266_abnormal_metabolism0.57490893
164MP0003123_paternal_imprinting0.56552426
165MP0000681_abnormal_thyroid_gland0.54914066
166MP0001881_abnormal_mammary_gland0.53986120
167MP0009642_abnormal_blood_homeostasis0.52733510
168MP0000343_altered_response_to0.52670470
169MP0005670_abnormal_white_adipose0.52393467
170MP0005451_abnormal_body_composition0.52243040
171MP0002234_abnormal_pharynx_morphology0.50264964
172MP0005397_hematopoietic_system_phenotyp0.49825106
173MP0001545_abnormal_hematopoietic_system0.49825106
174MP0003638_abnormal_response/metabolism_0.49717654
175MP0009384_cardiac_valve_regurgitation0.49473479
176MP0000465_gastrointestinal_hemorrhage0.49116998

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.79817317
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.79817317
3Neurofibrillary tangles (HP:0002185)5.56292217
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.22689931
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.11853005
6Deep venous thrombosis (HP:0002625)4.99252104
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.79655009
8Absent/shortened dynein arms (HP:0200106)4.77092273
9Dynein arm defect of respiratory motile cilia (HP:0012255)4.77092273
10Abnormality of the corticospinal tract (HP:0002492)4.45549930
11Hyperglycinemia (HP:0002154)4.26628659
12Hypobetalipoproteinemia (HP:0003563)4.15728146
13Complement deficiency (HP:0004431)4.12668266
14Cerebral inclusion bodies (HP:0100314)4.07787942
15Hyperammonemia (HP:0001987)3.84335519
16Prolonged partial thromboplastin time (HP:0003645)3.83731058
17Insidious onset (HP:0003587)3.79385456
18Termporal pattern (HP:0011008)3.79385456
19Peripheral hypomyelination (HP:0007182)3.71415597
20Intrahepatic cholestasis (HP:0001406)3.68485806
21Abnormal respiratory motile cilium physiology (HP:0012261)3.66142963
22Supranuclear gaze palsy (HP:0000605)3.64249953
23Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.57873453
24Retinal dysplasia (HP:0007973)3.57003352
25Abnormality of fatty-acid metabolism (HP:0004359)3.49369404
26Generalized aminoaciduria (HP:0002909)3.48184705
27Hyperglycinuria (HP:0003108)3.39913986
28Parakeratosis (HP:0001036)3.37518451
29Ankle clonus (HP:0011448)3.37059589
30Conjugated hyperbilirubinemia (HP:0002908)3.35473035
31Abnormal ciliary motility (HP:0012262)3.33615864
32Abnormal respiratory epithelium morphology (HP:0012253)3.33362934
33Abnormal respiratory motile cilium morphology (HP:0005938)3.33362934
34Sensorimotor neuropathy (HP:0007141)3.29917326
35Onion bulb formation (HP:0003383)3.27621303
36Abnormality of serine family amino acid metabolism (HP:0010894)3.23395698
37Abnormality of glycine metabolism (HP:0010895)3.23395698
38Spastic gait (HP:0002064)3.16664844
39Cerebral hypomyelination (HP:0006808)3.12333615
40Abnormality of complement system (HP:0005339)3.06698712
41Sensory axonal neuropathy (HP:0003390)3.03322762
42Myokymia (HP:0002411)3.00975678
43Hepatic necrosis (HP:0002605)2.97584921
44Pheochromocytoma (HP:0002666)2.87407137
45Fat malabsorption (HP:0002630)2.84791455
46Delayed CNS myelination (HP:0002188)2.84527587
47Rhinitis (HP:0012384)2.79603931
48Cerebral edema (HP:0002181)2.79559692
49Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.79078399
50Increased serum pyruvate (HP:0003542)2.77751743
51Abnormality of glycolysis (HP:0004366)2.77751743
52Abnormal auditory evoked potentials (HP:0006958)2.76326208
53Leukodystrophy (HP:0002415)2.75558985
54Dysmetria (HP:0001310)2.73976225
55Reduced antithrombin III activity (HP:0001976)2.70512002
56Hepatocellular necrosis (HP:0001404)2.67338230
57Rhabdomyolysis (HP:0003201)2.67251362
58Abnormality of serum amino acid levels (HP:0003112)2.66534478
59Dicarboxylic aciduria (HP:0003215)2.66042592
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66042592
61Segmental peripheral demyelination/remyelination (HP:0003481)2.64683347
62Intention tremor (HP:0002080)2.63781914
63Cerebral palsy (HP:0100021)2.62843134
64Myoglobinuria (HP:0002913)2.60452757
65Systemic lupus erythematosus (HP:0002725)2.58816526
66Back pain (HP:0003418)2.58076057
67Steatorrhea (HP:0002570)2.57229876
68Hypolipoproteinemia (HP:0010981)2.51234046
69Neuroendocrine neoplasm (HP:0100634)2.48354240
70Lethargy (HP:0001254)2.40552906
71Lower limb muscle weakness (HP:0007340)2.40211110
72Scanning speech (HP:0002168)2.39177954
73Glycosuria (HP:0003076)2.39032676
74Abnormality of urine glucose concentration (HP:0011016)2.39032676
75Xanthomatosis (HP:0000991)2.38445143
76Metabolic acidosis (HP:0001942)2.35803074
77Gout (HP:0001997)2.35436044
78Alacrima (HP:0000522)2.33422562
79Tubulointerstitial nephritis (HP:0001970)2.33306777
80Focal motor seizures (HP:0011153)2.32875595
81Medial flaring of the eyebrow (HP:0010747)2.30398201
82Increased muscle lipid content (HP:0009058)2.29299323
83Reticulocytosis (HP:0001923)2.28854638
84Abnormality of glutamine family amino acid metabolism (HP:0010902)2.28186232
85Absent septum pellucidum (HP:0001331)2.27497613
86Increased intramyocellular lipid droplets (HP:0012240)2.26721227
87Hyperbilirubinemia (HP:0002904)2.26002045
88Anteriorly placed anus (HP:0001545)2.21923440
89Aplasia involving bones of the extremities (HP:0009825)2.21651891
90Aplasia involving bones of the upper limbs (HP:0009823)2.21651891
91Aplasia of the phalanges of the hand (HP:0009802)2.21651891
92Clumsiness (HP:0002312)2.21287151
93Brushfield spots (HP:0001088)2.20230588
94Urinary urgency (HP:0000012)2.20177161
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19624608
96Rimmed vacuoles (HP:0003805)2.18462015
97Abnormality of the intrinsic pathway (HP:0010989)2.18343072
98Slow saccadic eye movements (HP:0000514)2.18196600
99Decreased motor nerve conduction velocity (HP:0003431)2.17839755
100Abnormality of the common coagulation pathway (HP:0010990)2.17743142
101Vaginal atresia (HP:0000148)2.16985353
102Type II lissencephaly (HP:0007260)2.14883317
103Joint hemorrhage (HP:0005261)2.14573188
104Acute necrotizing encephalopathy (HP:0006965)2.13923176
105Genital tract atresia (HP:0001827)2.13694794
106Muscle hypertrophy of the lower extremities (HP:0008968)2.11378479
107Foot dorsiflexor weakness (HP:0009027)2.11266370
108Hypoplastic pelvis (HP:0008839)2.08864215
109Cholelithiasis (HP:0001081)2.07634806
110Action tremor (HP:0002345)2.07261903
111Spastic paraparesis (HP:0002313)2.06965254
112Autoamputation (HP:0001218)2.06117265
113CNS hypomyelination (HP:0003429)2.04991647
114Epileptic encephalopathy (HP:0200134)2.04900929
115Metaphyseal dysplasia (HP:0100255)2.04391700
116Gait imbalance (HP:0002141)2.03267622
117CNS demyelination (HP:0007305)2.02405525
118Abnormality of pyrimidine metabolism (HP:0004353)2.02193295
119Megalencephaly (HP:0001355)2.01917470
120Ragged-red muscle fibers (HP:0003200)2.01903638
121Clonus (HP:0002169)2.01558601
122Mitochondrial inheritance (HP:0001427)2.01095462
123Renal Fanconi syndrome (HP:0001994)1.96997117
124Lipid accumulation in hepatocytes (HP:0006561)1.96894337
125Epiphyseal stippling (HP:0010655)1.96460817
126Hyperphosphaturia (HP:0003109)1.95864367
127Cerebral hemorrhage (HP:0001342)1.95018064
128Gowers sign (HP:0003391)1.94224011
129Poor speech (HP:0002465)1.94032749
130Lactic acidosis (HP:0003128)1.93884994
131Abnormality of the foot musculature (HP:0001436)1.93354801
132Spastic tetraparesis (HP:0001285)1.92915800
133Abnormal gallbladder morphology (HP:0012437)1.92859234
134Hypoglycemic coma (HP:0001325)1.91317252
135Muscle fiber splitting (HP:0003555)1.90666474
136Stridor (HP:0010307)1.89767641
137Abnormality of the septum pellucidum (HP:0007375)1.89029104
138Microglossia (HP:0000171)1.87763781
139Abnormality of methionine metabolism (HP:0010901)1.87456040
140Progressive cerebellar ataxia (HP:0002073)1.87172059
141Increased CSF lactate (HP:0002490)1.86801389
142Abnormality of nucleobase metabolism (HP:0010932)1.85804422
143Limb dystonia (HP:0002451)1.85539373
144Spontaneous abortion (HP:0005268)1.85239951
145Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.83799644
146Morphological abnormality of the pyramidal tract (HP:0002062)1.83354761
147Hammertoe (HP:0001765)1.82717616
148Decreased lacrimation (HP:0000633)1.81950829
149Abnormal mitochondria in muscle tissue (HP:0008316)1.81404484
150Morphological abnormality of the inner ear (HP:0011390)1.80853028
151Steppage gait (HP:0003376)1.80571440
152Exercise-induced muscle cramps (HP:0003710)1.80430037
153Beaking of vertebral bodies (HP:0004568)1.80327216
154Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78326189
155Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78326189
156Abnormality of purine metabolism (HP:0004352)1.78292854
157Congenital primary aphakia (HP:0007707)1.78045862
158Congenital ichthyosiform erythroderma (HP:0007431)1.76165967
159Methylmalonic acidemia (HP:0002912)1.75732408
160Progressive macrocephaly (HP:0004481)1.75556004
161Akinesia (HP:0002304)1.75359135
162Cholecystitis (HP:0001082)1.75260236
163Abnormal gallbladder physiology (HP:0012438)1.75260236
164Increased circulating renin level (HP:0000848)1.75145443
165Increased hepatocellular lipid droplets (HP:0006565)1.73959421
166Polyphagia (HP:0002591)1.73921841
167Split foot (HP:0001839)1.73286261
168Hypercholesterolemia (HP:0003124)1.72674101
169Thickened helices (HP:0000391)1.72474711
170Bell-shaped thorax (HP:0001591)1.70983122
171Irritability (HP:0000737)1.70528520
172Distal sensory impairment (HP:0002936)1.70006541
173Vomiting (HP:0002013)1.69491934
174Prolonged neonatal jaundice (HP:0006579)1.68512425
175Abnormal biliary tract physiology (HP:0012439)1.68166329
176Bile duct proliferation (HP:0001408)1.68166329
177Proximal tubulopathy (HP:0000114)1.67741179
178Acute encephalopathy (HP:0006846)1.67471637
179Hypoplasia of the brainstem (HP:0002365)1.66938333
180Aplasia/Hypoplasia of the brainstem (HP:0007362)1.66938333
181Chronic bronchitis (HP:0004469)1.65766559
182Focal seizures (HP:0007359)1.64750697
183Hyporeflexia of lower limbs (HP:0002600)1.64637199
184Nephronophthisis (HP:0000090)1.64506511
185Neuronal loss in central nervous system (HP:0002529)1.64399355
186Shoulder girdle muscle weakness (HP:0003547)1.64215896
187Muscle stiffness (HP:0003552)1.64017919
188Abnormality of reticulocytes (HP:0004312)1.63945977
189Infertility (HP:0000789)1.63635852
190Dysdiadochokinesis (HP:0002075)1.63325623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.70619468
2SCYL25.22935658
3OXSR13.62634823
4BCKDK3.56110633
5MAPKAPK53.03329570
6EPHB12.84736889
7PIM22.80409778
8WNK42.75337330
9PNCK2.54907105
10BCR2.44145522
11NEK12.43136580
12NME22.30472657
13PKN12.19666657
14PBK2.17292972
15EIF2AK12.06484424
16WNK12.01559261
17PDK42.00937976
18PDK32.00937976
19CDK191.90781838
20LIMK11.88049703
21MARK11.85241008
22UHMK11.81800099
23EIF2AK31.80566671
24PIK3CA1.79047712
25PRKD31.78981022
26CASK1.77914067
27FGFR21.64522455
28ABL21.57632770
29MET1.54353481
30TIE11.53951799
31NTRK11.51579058
32VRK21.51482487
33MAP3K121.50694230
34ICK1.48678561
35PDK21.48658913
36FLT31.48243611
37TESK21.46044819
38SGK2231.44907708
39SGK4941.44907708
40CAMK2B1.42818128
41NEK91.39221827
42SRPK11.37658663
43PHKG11.32668174
44PHKG21.32668174
45PRPF4B1.31125307
46ROCK21.30550634
47PAK61.29959868
48CAMK2D1.29353638
49CSNK1G31.28553632
50MAP2K41.24033120
51TNIK1.23383982
52NEK61.21939240
53CDC71.20949714
54ERBB31.19928685
55DYRK21.18214781
56MAPKAPK31.16141635
57CSNK1A1L1.12980125
58MAP4K21.08289015
59CSNK1G21.05557746
60TESK11.05232498
61CAMK2A1.05061182
62PAK31.04278533
63DAPK11.00608250
64MAP3K41.00523404
65BMPR1B0.98887149
66VRK10.98038623
67NTRK20.97548154
68PTK2B0.96721977
69CAMK2G0.96699493
70MAPK130.95959208
71EPHA40.94803670
72RPS6KA40.94545880
73CLK10.94543165
74FGR0.94538245
75KIT0.93011619
76CDK50.92478671
77CDK140.91384028
78NTRK30.91151416
79TYRO30.88265165
80CSNK1G10.86851862
81DYRK30.85026121
82CCNB10.84439854
83MARK20.84115493
84MUSK0.83567746
85MAPK150.80921409
86PINK10.80158075
87MINK10.79383068
88CDK150.79128529
89CDK80.79104605
90PRKCE0.78964874
91RAF10.78741384
92BRAF0.77628074
93OBSCN0.77383037
94CDK180.76960642
95MAP2K70.76832436
96DYRK1B0.73304167
97RPS6KB20.71060480
98CDK11A0.69355928
99IRAK20.68904895
100ARAF0.67219076
101AURKA0.65452621
102KSR20.62217914
103GRK70.61887570
104PRKD10.61597568
105PLK20.60964052
106MAP3K110.60101913
107CAMK1G0.59247151
108MYLK0.58929328
109AKT20.58773410
110WNK30.58489904
111PAK40.56922451
112PRKCQ0.56806838
113KDR0.55870336
114CDK60.53452386
115TTK0.53336030
116IRAK10.53228358
117MAP3K90.52508271
118PLK10.51914054
119CSNK2A10.51639769
120CSNK2A20.50703095
121PDPK10.49359836
122MAP3K60.49357577
123PRKG10.48292502
124DYRK1A0.48177734
125PRKACB0.46053102
126RPS6KA50.45334783
127PAK20.43826978
128PRKACG0.43569926
129AURKB0.42462527
130PLK40.42218670
131ERBB40.41070028
132PIK3CG0.40974453
133PRKCG0.40806696
134LMTK20.40685978
135GRK50.40399269
136CDK90.39752942
137MST40.39162164
138MAP3K50.38935867
139ATR0.38320245
140PDK10.37379379
141DAPK30.36242267
142DDR20.35417482
143FYN0.35107364
144PRKACA0.35001923
145CSNK1E0.34623414
146EPHA30.33739513
147CSNK1A10.33236607
148CSNK1D0.32725653
149MAP3K20.30872830
150ADRBK20.30322297
151GSK3A0.29747696
152PAK10.29646077
153MKNK10.29237966
154STK160.29146762

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.79966389
2Fatty acid elongation_Homo sapiens_hsa000623.84671763
3Steroid biosynthesis_Homo sapiens_hsa001003.80454380
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.11621117
5Primary bile acid biosynthesis_Homo sapiens_hsa001203.00239206
6Ether lipid metabolism_Homo sapiens_hsa005652.75688660
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66198533
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.64012743
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49704296
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.46102803
11Oxidative phosphorylation_Homo sapiens_hsa001902.42181360
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.39001738
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.38188330
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30794978
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28116870
16Chemical carcinogenesis_Homo sapiens_hsa052042.16441950
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.16116928
18Caffeine metabolism_Homo sapiens_hsa002322.16011152
19Retinol metabolism_Homo sapiens_hsa008302.15669588
20Fatty acid degradation_Homo sapiens_hsa000712.14094417
21Drug metabolism - other enzymes_Homo sapiens_hsa009832.09092873
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.05605397
23Parkinsons disease_Homo sapiens_hsa050122.03433132
24Vitamin B6 metabolism_Homo sapiens_hsa007501.97246447
25Complement and coagulation cascades_Homo sapiens_hsa046101.96303454
26Arginine biosynthesis_Homo sapiens_hsa002201.92315350
27Peroxisome_Homo sapiens_hsa041461.91060200
28Phenylalanine metabolism_Homo sapiens_hsa003601.87042169
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86286094
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85337148
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76666860
32Alzheimers disease_Homo sapiens_hsa050101.74927099
33GABAergic synapse_Homo sapiens_hsa047271.70809316
34Carbon metabolism_Homo sapiens_hsa012001.70330190
35Cardiac muscle contraction_Homo sapiens_hsa042601.66916045
36Tyrosine metabolism_Homo sapiens_hsa003501.62682995
37Glutamatergic synapse_Homo sapiens_hsa047241.60407157
38Biosynthesis of amino acids_Homo sapiens_hsa012301.57203093
39Axon guidance_Homo sapiens_hsa043601.55294360
40Serotonergic synapse_Homo sapiens_hsa047261.53859015
41Sulfur metabolism_Homo sapiens_hsa009201.51275297
42Sulfur relay system_Homo sapiens_hsa041221.51212587
43Linoleic acid metabolism_Homo sapiens_hsa005911.49922554
44Nicotine addiction_Homo sapiens_hsa050331.49370076
45beta-Alanine metabolism_Homo sapiens_hsa004101.49132040
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.48218932
47Sphingolipid metabolism_Homo sapiens_hsa006001.47774849
48Morphine addiction_Homo sapiens_hsa050321.44879593
49Circadian entrainment_Homo sapiens_hsa047131.40997118
50Huntingtons disease_Homo sapiens_hsa050161.40868224
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.40799903
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40638638
53Protein export_Homo sapiens_hsa030601.39765028
54Tryptophan metabolism_Homo sapiens_hsa003801.36357202
55Synaptic vesicle cycle_Homo sapiens_hsa047211.35003506
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34925055
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32357757
58Starch and sucrose metabolism_Homo sapiens_hsa005001.31989621
59Collecting duct acid secretion_Homo sapiens_hsa049661.30292316
60Long-term depression_Homo sapiens_hsa047301.29414219
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24034283
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21662229
63Base excision repair_Homo sapiens_hsa034101.14275321
64SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13949875
65PPAR signaling pathway_Homo sapiens_hsa033201.13933911
66Vibrio cholerae infection_Homo sapiens_hsa051101.13409272
67Butanoate metabolism_Homo sapiens_hsa006501.12787962
68Dopaminergic synapse_Homo sapiens_hsa047281.12350789
69Cocaine addiction_Homo sapiens_hsa050301.11952879
70Bile secretion_Homo sapiens_hsa049761.07438238
71Salivary secretion_Homo sapiens_hsa049701.04491897
72Renin secretion_Homo sapiens_hsa049241.03704441
73Amphetamine addiction_Homo sapiens_hsa050311.03677565
74DNA replication_Homo sapiens_hsa030301.02363570
75Gastric acid secretion_Homo sapiens_hsa049711.01907930
76Folate biosynthesis_Homo sapiens_hsa007901.00764400
77Pyruvate metabolism_Homo sapiens_hsa006200.99490936
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.98211828
79Taste transduction_Homo sapiens_hsa047420.97664811
80Pentose phosphate pathway_Homo sapiens_hsa000300.97057715
81Propanoate metabolism_Homo sapiens_hsa006400.96439568
82Phototransduction_Homo sapiens_hsa047440.93950808
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91358106
84Cholinergic synapse_Homo sapiens_hsa047250.89188667
85Renal cell carcinoma_Homo sapiens_hsa052110.88114738
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88057487
87Dorso-ventral axis formation_Homo sapiens_hsa043200.87818547
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87280835
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86635595
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86076002
91Long-term potentiation_Homo sapiens_hsa047200.85803460
92Fat digestion and absorption_Homo sapiens_hsa049750.85053768
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.84424417
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84152469
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83200401
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82620018
97Histidine metabolism_Homo sapiens_hsa003400.82346187
98Tight junction_Homo sapiens_hsa045300.81341818
99One carbon pool by folate_Homo sapiens_hsa006700.81173926
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.79685980
101Gap junction_Homo sapiens_hsa045400.79353949
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.78161720
103Olfactory transduction_Homo sapiens_hsa047400.77955258
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.77482979
105Fatty acid biosynthesis_Homo sapiens_hsa000610.76651734
106Fructose and mannose metabolism_Homo sapiens_hsa000510.75360913
107Insulin secretion_Homo sapiens_hsa049110.74603689
108Mismatch repair_Homo sapiens_hsa034300.72373502
109Arginine and proline metabolism_Homo sapiens_hsa003300.70543297
110Fatty acid metabolism_Homo sapiens_hsa012120.70483893
111Mineral absorption_Homo sapiens_hsa049780.68681528
112Ovarian steroidogenesis_Homo sapiens_hsa049130.66700203
113Calcium signaling pathway_Homo sapiens_hsa040200.66001577
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65413413
115Pancreatic secretion_Homo sapiens_hsa049720.64834962
116Hedgehog signaling pathway_Homo sapiens_hsa043400.63054209
117Ras signaling pathway_Homo sapiens_hsa040140.61784488
118Renin-angiotensin system_Homo sapiens_hsa046140.61222189
119Endocytosis_Homo sapiens_hsa041440.60622027
120Proteasome_Homo sapiens_hsa030500.58858964
121Oxytocin signaling pathway_Homo sapiens_hsa049210.58365454
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58075221
123cAMP signaling pathway_Homo sapiens_hsa040240.57863978
124Pyrimidine metabolism_Homo sapiens_hsa002400.57805575
125Arachidonic acid metabolism_Homo sapiens_hsa005900.57732686
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57533745
127Galactose metabolism_Homo sapiens_hsa000520.56628131
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.55424336
129Dilated cardiomyopathy_Homo sapiens_hsa054140.54865426
130Ribosome_Homo sapiens_hsa030100.51390022
131Phagosome_Homo sapiens_hsa041450.50661303
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50354042
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47574079
134Melanogenesis_Homo sapiens_hsa049160.47195405
135Alcoholism_Homo sapiens_hsa050340.47161227
136Rheumatoid arthritis_Homo sapiens_hsa053230.44655748
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44302210
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43685710
139ErbB signaling pathway_Homo sapiens_hsa040120.41560641
140Nucleotide excision repair_Homo sapiens_hsa034200.41086208
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40105444
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40075184
143Metabolic pathways_Homo sapiens_hsa011000.39654646
144Other glycan degradation_Homo sapiens_hsa005110.39181970
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38664511
146Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37182198
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36283070
148Nitrogen metabolism_Homo sapiens_hsa009100.36171649
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35374685
150Glutathione metabolism_Homo sapiens_hsa004800.34779995
151Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33763869
152Oocyte meiosis_Homo sapiens_hsa041140.32427481
153Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32372786
154N-Glycan biosynthesis_Homo sapiens_hsa005100.31864468
155Choline metabolism in cancer_Homo sapiens_hsa052310.31582450
156Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31135893
157Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30534192
158Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27602875
159Prion diseases_Homo sapiens_hsa050200.27004155
160Purine metabolism_Homo sapiens_hsa002300.25298904
161Lysine degradation_Homo sapiens_hsa003100.22173172
162Maturity onset diabetes of the young_Homo sapiens_hsa049500.20281914
163ABC transporters_Homo sapiens_hsa020100.16995312
164Vitamin digestion and absorption_Homo sapiens_hsa049770.15708762
165Lysosome_Homo sapiens_hsa041420.14831725
166Fanconi anemia pathway_Homo sapiens_hsa034600.14123924
167Glycerolipid metabolism_Homo sapiens_hsa005610.13930335
168Non-homologous end-joining_Homo sapiens_hsa034500.13799146
169Spliceosome_Homo sapiens_hsa030400.10615035

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