SCAND2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.97235344
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.25132945
3cellular response to ATP (GO:0071318)4.07614876
4fucose catabolic process (GO:0019317)3.82596281
5L-fucose metabolic process (GO:0042354)3.82596281
6L-fucose catabolic process (GO:0042355)3.82596281
7detection of light stimulus involved in visual perception (GO:0050908)3.77715502
8detection of light stimulus involved in sensory perception (GO:0050962)3.77715502
9sulfation (GO:0051923)3.70554738
10negative regulation of translation, ncRNA-mediated (GO:0040033)3.64675916
11regulation of translation, ncRNA-mediated (GO:0045974)3.64675916
12negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.64675916
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.46187801
14regulation of skeletal muscle contraction (GO:0014819)3.38578935
15DNA deamination (GO:0045006)3.33268226
16indolalkylamine metabolic process (GO:0006586)3.29932221
17tryptophan catabolic process (GO:0006569)3.22235421
18indole-containing compound catabolic process (GO:0042436)3.22235421
19indolalkylamine catabolic process (GO:0046218)3.22235421
20cellular response to exogenous dsRNA (GO:0071360)3.17097819
21neuronal action potential (GO:0019228)3.16769124
22interkinetic nuclear migration (GO:0022027)3.16514190
23kynurenine metabolic process (GO:0070189)3.16314540
24gamma-aminobutyric acid transport (GO:0015812)3.13469639
25membrane depolarization during action potential (GO:0086010)3.04505731
26activated T cell proliferation (GO:0050798)3.03669946
27urinary tract smooth muscle contraction (GO:0014848)3.01179036
28membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.01094115
29regulation of hippo signaling (GO:0035330)2.93059376
30negative regulation of Rho protein signal transduction (GO:0035024)2.83954935
31kidney morphogenesis (GO:0060993)2.82948366
32cAMP catabolic process (GO:0006198)2.79608677
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.78942021
34positive regulation of defense response to virus by host (GO:0002230)2.78888356
35spinal cord motor neuron differentiation (GO:0021522)2.74513014
36negative regulation of telomere maintenance (GO:0032205)2.74467587
37membrane repolarization during action potential (GO:0086011)2.74262659
38tryptophan metabolic process (GO:0006568)2.72266300
39purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.71743198
403-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.71743198
41neural tube formation (GO:0001841)2.71737101
42cellular ketone body metabolic process (GO:0046950)2.66967921
43positive regulation of CREB transcription factor activity (GO:0032793)2.66355590
44cornea development in camera-type eye (GO:0061303)2.65581860
45regulation of gene silencing by RNA (GO:0060966)2.63140452
46regulation of posttranscriptional gene silencing (GO:0060147)2.63140452
47regulation of gene silencing by miRNA (GO:0060964)2.63140452
48negative regulation of cytosolic calcium ion concentration (GO:0051481)2.60980592
49negative regulation of mast cell activation (GO:0033004)2.60311437
50positive regulation of fatty acid oxidation (GO:0046321)2.58489576
51cilium or flagellum-dependent cell motility (GO:0001539)2.57999288
52negative regulation of systemic arterial blood pressure (GO:0003085)2.56128514
53purinergic nucleotide receptor signaling pathway (GO:0035590)2.56093851
54reflex (GO:0060004)2.55535369
55negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54760837
56indole-containing compound metabolic process (GO:0042430)2.54424477
57protein import into peroxisome matrix (GO:0016558)2.53975874
58oxidative demethylation (GO:0070989)2.53231734
59startle response (GO:0001964)2.51426460
60cyclic nucleotide catabolic process (GO:0009214)2.51297819
61nephron tubule morphogenesis (GO:0072078)2.50691985
62nephron epithelium morphogenesis (GO:0072088)2.50691985
63cardiovascular system development (GO:0072358)2.49230534
64snRNA transcription (GO:0009301)2.47148463
65action potential (GO:0001508)2.46804422
66regulation of action potential (GO:0098900)2.46797444
67preassembly of GPI anchor in ER membrane (GO:0016254)2.46590016
68peristalsis (GO:0030432)2.46304036
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45563589
70establishment of protein localization to Golgi (GO:0072600)2.44839787
71serotonin metabolic process (GO:0042428)2.44658924
72head development (GO:0060322)2.41396528
73axoneme assembly (GO:0035082)2.40829222
74synaptic transmission, cholinergic (GO:0007271)2.40108135
75replicative senescence (GO:0090399)2.39914043
76adaptation of signaling pathway (GO:0023058)2.39778907
77epithelial cilium movement (GO:0003351)2.38793858
78water-soluble vitamin biosynthetic process (GO:0042364)2.37952768
79primary amino compound metabolic process (GO:1901160)2.36610549
80positive regulation of fatty acid transport (GO:2000193)2.34858723
81regulation of nuclear cell cycle DNA replication (GO:0033262)2.33763689
82positive regulation of developmental pigmentation (GO:0048087)2.33137960
83negative regulation of reactive oxygen species metabolic process (GO:2000378)2.32857086
84protein polyglutamylation (GO:0018095)2.32544263
85DNA methylation involved in gamete generation (GO:0043046)2.32352849
86protein K11-linked deubiquitination (GO:0035871)2.32211905
87ketone body metabolic process (GO:1902224)2.32135216
88rRNA catabolic process (GO:0016075)2.31515859
89protein K48-linked deubiquitination (GO:0071108)2.31404190
90NAD biosynthetic process (GO:0009435)2.31371797
91cell proliferation in forebrain (GO:0021846)2.29775055
92somite development (GO:0061053)2.28660427
93reciprocal DNA recombination (GO:0035825)2.26594966
94reciprocal meiotic recombination (GO:0007131)2.26594966
95regulation of membrane repolarization (GO:0060306)2.26263590
96regulation of mesoderm development (GO:2000380)2.25725950
97positive regulation of protein kinase C signaling (GO:0090037)2.22643186
98regulation of pigment cell differentiation (GO:0050932)2.22096160
99regulation of telomere maintenance (GO:0032204)2.21911165
100neuromuscular synaptic transmission (GO:0007274)2.20781937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.63494273
2ZNF274_21170338_ChIP-Seq_K562_Hela3.21286568
3GBX2_23144817_ChIP-Seq_PC3_Human2.93149328
4VDR_22108803_ChIP-Seq_LS180_Human2.69038825
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.68114499
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.64687857
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29842087
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28083659
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26216060
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90172036
11TAF15_26573619_Chip-Seq_HEK293_Human1.87240693
12CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86036125
13EWS_26573619_Chip-Seq_HEK293_Human1.84801662
14ER_23166858_ChIP-Seq_MCF-7_Human1.79704460
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79330091
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78042705
17CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74588136
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70944723
19IGF1R_20145208_ChIP-Seq_DFB_Human1.67367990
20DROSHA_22980978_ChIP-Seq_HELA_Human1.66472159
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64566381
22FUS_26573619_Chip-Seq_HEK293_Human1.62693803
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.61953289
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61637056
25STAT3_23295773_ChIP-Seq_U87_Human1.60800333
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59312309
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59312309
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57932453
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56689162
30P300_19829295_ChIP-Seq_ESCs_Human1.56353109
31REST_21632747_ChIP-Seq_MESCs_Mouse1.53859802
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.53813623
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.47470196
34BCAT_22108803_ChIP-Seq_LS180_Human1.46379825
35IRF1_19129219_ChIP-ChIP_H3396_Human1.44675179
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.43328480
37TCF4_23295773_ChIP-Seq_U87_Human1.42813868
38AR_21572438_ChIP-Seq_LNCaP_Human1.36636550
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35514367
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35285583
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.33837714
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32741492
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32057324
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30027041
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28641727
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28019314
47SMAD4_21799915_ChIP-Seq_A2780_Human1.27339112
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.26486813
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22277665
50AR_25329375_ChIP-Seq_VCAP_Human1.22168009
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21269719
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21120661
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.19997698
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19377992
55TP53_22573176_ChIP-Seq_HFKS_Human1.17343112
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.16516417
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15448557
58PRDM14_20953172_ChIP-Seq_ESCs_Human1.14113603
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13663480
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11015497
61CBP_20019798_ChIP-Seq_JUKART_Human1.11015497
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.10790495
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09840418
64TP53_16413492_ChIP-PET_HCT116_Human1.09500485
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08992870
66AHR_22903824_ChIP-Seq_MCF-7_Human1.08867545
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.07344636
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.07210453
69ERA_21632823_ChIP-Seq_H3396_Human1.06616503
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03705633
71RNF2_27304074_Chip-Seq_NSC_Mouse1.02926519
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.02692586
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.02418038
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.01968486
75TCF4_22108803_ChIP-Seq_LS180_Human1.01275743
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.01222211
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01067465
78SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00803178
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.00266925
80RUNX2_22187159_ChIP-Seq_PCA_Human1.00101401
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00090986
82TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99912927
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99432867
84SOX2_21211035_ChIP-Seq_LN229_Gbm0.98890327
85NCOR_22424771_ChIP-Seq_293T_Human0.98678805
86IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98110914
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97853217
88REST_18959480_ChIP-ChIP_MESCs_Mouse0.97170310
89NANOG_19829295_ChIP-Seq_ESCs_Human0.96925815
90SOX2_19829295_ChIP-Seq_ESCs_Human0.96925815
91HOXB7_26014856_ChIP-Seq_BT474_Human0.95655605
92FOXA1_25329375_ChIP-Seq_VCAP_Human0.94763031
93FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94763031
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94712886
95SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93946611
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93744981
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93465212
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91277463
99RUNX_20019798_ChIP-Seq_JUKART_Human0.90958006
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90384586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.31553195
2MP0001986_abnormal_taste_sensitivity3.00444847
3MP0005174_abnormal_tail_pigmentation2.96823143
4MP0003646_muscle_fatigue2.94654781
5MP0003136_yellow_coat_color2.87787857
6MP0001968_abnormal_touch/_nociception2.63206207
7MP0004142_abnormal_muscle_tone2.30920013
8MP0008877_abnormal_DNA_methylation2.27178785
9MP0004130_abnormal_muscle_cell2.23141142
10MP0005551_abnormal_eye_electrophysiolog2.15162548
11MP0002837_dystrophic_cardiac_calcinosis2.04079652
12MP0004043_abnormal_pH_regulation1.97470398
13MP0002653_abnormal_ependyma_morphology1.88428532
14MP0009046_muscle_twitch1.88022794
15MP0003195_calcinosis1.87652119
16MP0002102_abnormal_ear_morphology1.87634140
17MP0009745_abnormal_behavioral_response1.83209091
18MP0002736_abnormal_nociception_after1.78671028
19MP0002638_abnormal_pupillary_reflex1.77176324
20MP0004145_abnormal_muscle_electrophysio1.74748953
21MP0002160_abnormal_reproductive_system1.73542119
22MP0003787_abnormal_imprinting1.70622049
23MP0008872_abnormal_physiological_respon1.69635167
24MP0002876_abnormal_thyroid_physiology1.65893241
25MP0005423_abnormal_somatic_nervous1.65870253
26MP0001485_abnormal_pinna_reflex1.64750781
27MP0002272_abnormal_nervous_system1.63181383
28MP0000427_abnormal_hair_cycle1.61480816
29MP0005171_absent_coat_pigmentation1.58343642
30MP0002735_abnormal_chemical_nociception1.57107097
31MP0001501_abnormal_sleep_pattern1.55915971
32MP0004885_abnormal_endolymph1.54725547
33MP0005646_abnormal_pituitary_gland1.52857560
34MP0002064_seizures1.51880653
35MP0001486_abnormal_startle_reflex1.46616244
36MP0002928_abnormal_bile_duct1.37743475
37MP0001188_hyperpigmentation1.37360245
38MP0004215_abnormal_myocardial_fiber1.37346410
39MP0001502_abnormal_circadian_rhythm1.36492610
40MP0002572_abnormal_emotion/affect_behav1.36438720
41MP0000015_abnormal_ear_pigmentation1.35850579
42MP0005253_abnormal_eye_physiology1.35745494
43MP0005389_reproductive_system_phenotype1.34572795
44MP0001970_abnormal_pain_threshold1.32231632
45MP0003635_abnormal_synaptic_transmissio1.30785146
46MP0006072_abnormal_retinal_apoptosis1.30727335
47MP0004133_heterotaxia1.30723208
48MP0004147_increased_porphyrin_level1.30483310
49MP0002063_abnormal_learning/memory/cond1.28435065
50MP0008875_abnormal_xenobiotic_pharmacok1.27520916
51MP0000631_abnormal_neuroendocrine_gland1.25158592
52MP0002067_abnormal_sensory_capabilities1.24774871
53MP0002138_abnormal_hepatobiliary_system1.20999449
54MP0004381_abnormal_hair_follicle1.18678721
55MP0004924_abnormal_behavior1.17275546
56MP0005386_behavior/neurological_phenoty1.17275546
57MP0002733_abnormal_thermal_nociception1.15704981
58MP0005645_abnormal_hypothalamus_physiol1.14080593
59MP0000383_abnormal_hair_follicle1.12873958
60MP0000230_abnormal_systemic_arterial1.11995056
61MP0006292_abnormal_olfactory_placode1.09838281
62MP0008775_abnormal_heart_ventricle1.09778434
63MP0006276_abnormal_autonomic_nervous1.06089892
64MP0002557_abnormal_social/conspecific_i1.05249938
65MP0010386_abnormal_urinary_bladder1.03300214
66MP0008961_abnormal_basal_metabolism1.03181030
67MP0005083_abnormal_biliary_tract1.02545256
68MP0001919_abnormal_reproductive_system0.99773104
69MP0003011_delayed_dark_adaptation0.99509517
70MP0002095_abnormal_skin_pigmentation0.98277276
71MP0008057_abnormal_DNA_replication0.94847619
72MP0003137_abnormal_impulse_conducting0.94137912
73MP0005167_abnormal_blood-brain_barrier0.89068738
74MP0005448_abnormal_energy_balance0.86510483
75MP0005195_abnormal_posterior_eye0.85952671
76MP0002734_abnormal_mechanical_nocicepti0.83671488
77MP0002938_white_spotting0.83545792
78MP0001765_abnormal_ion_homeostasis0.82697406
79MP0005671_abnormal_response_to0.82545004
80MP0001756_abnormal_urination0.82456514
81MP0003879_abnormal_hair_cell0.82187870
82MP0001440_abnormal_grooming_behavior0.80759906
83MP0003045_fibrosis0.78726672
84MP0004085_abnormal_heartbeat0.78504744
85MP0000685_abnormal_immune_system0.77922698
86MP0002752_abnormal_somatic_nervous0.77408092
87MP0010329_abnormal_lipoprotein_level0.75417872
88MP0000470_abnormal_stomach_morphology0.75379985
89MP0000026_abnormal_inner_ear0.74398116
90MP0003880_abnormal_central_pattern0.73580005
91MP0008995_early_reproductive_senescence0.73275939
92MP0004742_abnormal_vestibular_system0.72545985
93MP0005084_abnormal_gallbladder_morpholo0.72539427
94MP0002909_abnormal_adrenal_gland0.72403667
95MP0001984_abnormal_olfaction0.72266436
96MP0000538_abnormal_urinary_bladder0.72128995
97MP0001800_abnormal_humoral_immune0.71709069
98MP0000778_abnormal_nervous_system0.70540615
99MP0002184_abnormal_innervation0.69967303
100MP0002229_neurodegeneration0.69724510

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.44205287
2Genetic anticipation (HP:0003743)3.95117432
3Congenital stationary night blindness (HP:0007642)3.90160219
4Pancreatic fibrosis (HP:0100732)3.79554167
5Nephronophthisis (HP:0000090)3.76172841
6Abnormality of midbrain morphology (HP:0002418)3.66371794
7Molar tooth sign on MRI (HP:0002419)3.66371794
8True hermaphroditism (HP:0010459)3.41727571
9Attenuation of retinal blood vessels (HP:0007843)3.40846021
10Hyperventilation (HP:0002883)3.39725055
11Abnormality of the renal medulla (HP:0100957)3.29480053
12Progressive cerebellar ataxia (HP:0002073)3.29434239
13Gaze-evoked nystagmus (HP:0000640)3.18114457
14Decreased circulating renin level (HP:0003351)3.04572692
15Chronic hepatic failure (HP:0100626)3.04426869
16Protruding tongue (HP:0010808)3.03024394
17Abnormality of the renal cortex (HP:0011035)2.97518142
18Clumsiness (HP:0002312)2.91922916
19Tubular atrophy (HP:0000092)2.90416303
20Type II lissencephaly (HP:0007260)2.83302341
21Patellar aplasia (HP:0006443)2.78855292
22Polydipsia (HP:0001959)2.78359789
23Abnormal drinking behavior (HP:0030082)2.78359789
24Cystic liver disease (HP:0006706)2.75465308
25Abolished electroretinogram (ERG) (HP:0000550)2.73587209
26Aplasia/Hypoplasia of the patella (HP:0006498)2.71399471
27Chorioretinal atrophy (HP:0000533)2.69071743
28Pendular nystagmus (HP:0012043)2.56069343
29Abnormality of alanine metabolism (HP:0010916)2.52193635
30Hyperalaninemia (HP:0003348)2.52193635
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.52193635
32Rib fusion (HP:0000902)2.50986018
33Bony spicule pigmentary retinopathy (HP:0007737)2.50344185
34Furrowed tongue (HP:0000221)2.48728724
35Stomach cancer (HP:0012126)2.44220586
36Inability to walk (HP:0002540)2.44201449
37Broad-based gait (HP:0002136)2.39794193
38Fair hair (HP:0002286)2.34479751
39Febrile seizures (HP:0002373)2.33802193
40Progressive inability to walk (HP:0002505)2.33087307
41Absent/shortened dynein arms (HP:0200106)2.31580847
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.31580847
43Decreased central vision (HP:0007663)2.27308910
44Birth length less than 3rd percentile (HP:0003561)2.27017913
45Large for gestational age (HP:0001520)2.26682716
46Medial flaring of the eyebrow (HP:0010747)2.21825889
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20728843
48Congenital hepatic fibrosis (HP:0002612)2.18856418
49Absent speech (HP:0001344)2.18129084
50Small hand (HP:0200055)2.14203614
51Bulbous nose (HP:0000414)2.12951268
52Abnormal rod and cone electroretinograms (HP:0008323)2.10204335
53Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09853921
54Congenital sensorineural hearing impairment (HP:0008527)2.09185524
55Abnormality of the renal collecting system (HP:0004742)2.07988200
56Abnormality of the pons (HP:0007361)2.07498540
57Hypoplasia of the pons (HP:0012110)2.07313870
58Polyuria (HP:0000103)2.06306203
59Increased corneal curvature (HP:0100692)2.06081706
60Keratoconus (HP:0000563)2.06081706
61Lissencephaly (HP:0001339)2.02310789
62Aplasia/Hypoplasia of the tibia (HP:0005772)1.98392112
63Cerebellar dysplasia (HP:0007033)1.97317772
64Absent thumb (HP:0009777)1.95064811
65Male pseudohermaphroditism (HP:0000037)1.93796017
66Impaired smooth pursuit (HP:0007772)1.91862825
67Sclerocornea (HP:0000647)1.87721598
68Prolonged QT interval (HP:0001657)1.85643272
69Duplicated collecting system (HP:0000081)1.85440059
70Widely spaced teeth (HP:0000687)1.83440292
71Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81277082
72Abnormal biliary tract physiology (HP:0012439)1.80870639
73Bile duct proliferation (HP:0001408)1.80870639
74Generalized hypopigmentation of hair (HP:0011358)1.79760812
75Hamartoma of the eye (HP:0010568)1.79710935
76Tented upper lip vermilion (HP:0010804)1.79583930
77Gait imbalance (HP:0002141)1.77981570
78Hemiparesis (HP:0001269)1.77976733
79Concave nail (HP:0001598)1.76333435
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.73334733
81Anencephaly (HP:0002323)1.73061476
82Abnormality of binocular vision (HP:0011514)1.69953483
83Diplopia (HP:0000651)1.69953483
84Ketosis (HP:0001946)1.69838427
85Hypoalbuminemia (HP:0003073)1.68560902
86Abnormal albumin level (HP:0012116)1.68560902
87Abnormal EKG (HP:0003115)1.68425929
88Tachypnea (HP:0002789)1.68164815
89Abnormality of the nasal septum (HP:0000419)1.67927329
90Abnormal respiratory motile cilium morphology (HP:0005938)1.66923966
91Abnormal respiratory epithelium morphology (HP:0012253)1.66923966
92Renal cortical cysts (HP:0000803)1.66631286
93Short chin (HP:0000331)1.66436870
94Syncope (HP:0001279)1.65050060
95Adactyly (HP:0009776)1.63448237
96Epileptic encephalopathy (HP:0200134)1.63345555
97Congenital primary aphakia (HP:0007707)1.61543230
98Abnormal urine output (HP:0012590)1.60026894
99Abnormality of renin-angiotensin system (HP:0000847)1.59975405
100Abnormal ciliary motility (HP:0012262)1.59957655

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.26723911
2BMPR1B3.01192981
3ACVR1B2.89950867
4ADRBK22.86645040
5TLK12.67682061
6WNK42.52939817
7PINK12.46093190
8ZAK2.09291740
9GRK12.08494907
10TAOK32.08396689
11MAPK131.97021251
12DAPK21.66591161
13MAPK151.65553008
14NTRK31.56924075
15INSRR1.52796140
16WNK31.45852088
17PAK31.45543153
18NUAK11.40850253
19CASK1.40464219
20MAP3K41.39703086
21AKT31.38842334
22TXK1.36223922
23ADRBK11.31472199
24SGK21.18857484
25SIK21.18199717
26CAMKK21.17378556
27MAP4K21.15713504
28MAPKAPK31.11907182
29MAP2K61.11870218
30PIK3CA1.10934191
31OXSR11.10165980
32TNIK1.09352638
33BLK1.05798737
34SGK2231.02422532
35SGK4941.02422532
36NLK1.02264906
37OBSCN0.99769572
38MARK10.96334519
39WNK10.93949090
40PHKG20.89826081
41PHKG10.89826081
42STK390.89759582
43FGFR20.89678545
44TEC0.89203856
45NTRK20.88501854
46TNK20.88473519
47STK110.87580022
48MKNK20.86491532
49PTK2B0.83310031
50PRKD20.82681362
51RPS6KA60.82372894
52TGFBR10.78555377
53SYK0.78272212
54MAP2K70.77923569
55MAP2K40.76602193
56IKBKB0.74788749
57ITK0.72418180
58CAMK1D0.70772932
59MAPK120.70427645
60TRPM70.70395367
61PRKAA10.69436338
62KIT0.69076846
63CAMK10.67724341
64PRKCG0.67508849
65MARK30.66790431
66MAP4K10.66688720
67PRKAA20.66559471
68PKN10.66419573
69PRKCQ0.64706708
70PRKCE0.59563869
71MUSK0.58967742
72MAP3K70.58027667
73GRK60.57657244
74SGK30.56074379
75BTK0.55982809
76MAPK110.55832974
77CAMKK10.54992050
78GRK70.54357617
79CAMK40.54312818
80CHUK0.54092391
81PRKCH0.52955570
82TYRO30.48802927
83IKBKE0.47043660
84LYN0.46578708
85PRKACA0.46536800
86CAMK1G0.45589297
87CAMK2A0.45505846
88SGK10.45213350
89PRKCZ0.42014978
90ERBB20.41198113
91MARK20.41108359
92DYRK1A0.39382011
93MAPK80.39150301
94DYRK20.39068096
95FES0.38835089
96CSNK1D0.38548063
97STK38L0.37789141
98LCK0.37629713
99PRKD10.36513846
100RPS6KA20.36469422

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.03477102
2Phototransduction_Homo sapiens_hsa047442.47799141
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.46989587
4Nitrogen metabolism_Homo sapiens_hsa009102.46514489
5Nicotine addiction_Homo sapiens_hsa050332.42327423
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.42281652
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29792652
8Linoleic acid metabolism_Homo sapiens_hsa005912.24204147
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.24187566
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04827925
11Morphine addiction_Homo sapiens_hsa050321.88505576
12Taste transduction_Homo sapiens_hsa047421.82604755
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76934514
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73222714
15Circadian entrainment_Homo sapiens_hsa047131.60266484
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.57561531
17Dorso-ventral axis formation_Homo sapiens_hsa043201.57004002
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56981788
19ABC transporters_Homo sapiens_hsa020101.55158503
20Butanoate metabolism_Homo sapiens_hsa006501.55134522
21Glutamatergic synapse_Homo sapiens_hsa047241.46575314
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.45330938
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40121740
24Insulin secretion_Homo sapiens_hsa049111.40015989
25Selenocompound metabolism_Homo sapiens_hsa004501.39590799
26Ether lipid metabolism_Homo sapiens_hsa005651.38422910
27Tryptophan metabolism_Homo sapiens_hsa003801.36123358
28Calcium signaling pathway_Homo sapiens_hsa040201.33364214
29Serotonergic synapse_Homo sapiens_hsa047261.27739964
30Homologous recombination_Homo sapiens_hsa034401.26471134
31Olfactory transduction_Homo sapiens_hsa047401.20316201
32GABAergic synapse_Homo sapiens_hsa047271.16459865
33Cholinergic synapse_Homo sapiens_hsa047251.14649040
34Ovarian steroidogenesis_Homo sapiens_hsa049131.08423255
35Fanconi anemia pathway_Homo sapiens_hsa034601.08219556
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.07658839
37Circadian rhythm_Homo sapiens_hsa047101.05514201
38Primary immunodeficiency_Homo sapiens_hsa053401.04614763
39Glycerolipid metabolism_Homo sapiens_hsa005611.04184235
40Oxytocin signaling pathway_Homo sapiens_hsa049211.02235759
41Chemical carcinogenesis_Homo sapiens_hsa052041.02117674
42Steroid hormone biosynthesis_Homo sapiens_hsa001400.99384950
43Gastric acid secretion_Homo sapiens_hsa049710.96846689
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96487250
45Regulation of autophagy_Homo sapiens_hsa041400.96374355
46Renin secretion_Homo sapiens_hsa049240.93699659
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93357066
48Basal transcription factors_Homo sapiens_hsa030220.91330052
49Histidine metabolism_Homo sapiens_hsa003400.89191970
50Salivary secretion_Homo sapiens_hsa049700.88246454
51Dopaminergic synapse_Homo sapiens_hsa047280.87610995
52cAMP signaling pathway_Homo sapiens_hsa040240.82565079
53Long-term depression_Homo sapiens_hsa047300.81981934
54Lysine degradation_Homo sapiens_hsa003100.80420131
55Sulfur relay system_Homo sapiens_hsa041220.79921950
56Type II diabetes mellitus_Homo sapiens_hsa049300.79009563
57Caffeine metabolism_Homo sapiens_hsa002320.78956994
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76966660
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76797950
60RNA polymerase_Homo sapiens_hsa030200.74485754
61Amphetamine addiction_Homo sapiens_hsa050310.71914862
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71501305
63Arachidonic acid metabolism_Homo sapiens_hsa005900.70814854
64Cocaine addiction_Homo sapiens_hsa050300.70317159
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65658409
66Cardiac muscle contraction_Homo sapiens_hsa042600.64041513
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63497325
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63032139
69MAPK signaling pathway_Homo sapiens_hsa040100.62926522
70Retinol metabolism_Homo sapiens_hsa008300.62660100
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.61693256
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60903316
73Vitamin digestion and absorption_Homo sapiens_hsa049770.59849395
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59398515
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.58695974
76Peroxisome_Homo sapiens_hsa041460.58231758
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57456269
78Hedgehog signaling pathway_Homo sapiens_hsa043400.54249437
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53554252
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51349496
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50031698
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49507520
83Insulin resistance_Homo sapiens_hsa049310.48326984
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47587486
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.46584854
86T cell receptor signaling pathway_Homo sapiens_hsa046600.45775262
87Graft-versus-host disease_Homo sapiens_hsa053320.43345390
88Mineral absorption_Homo sapiens_hsa049780.41180891
89Platelet activation_Homo sapiens_hsa046110.41025513
90FoxO signaling pathway_Homo sapiens_hsa040680.40288397
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38957473
92Asthma_Homo sapiens_hsa053100.37207991
93Ras signaling pathway_Homo sapiens_hsa040140.36228992
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34118093
95RNA degradation_Homo sapiens_hsa030180.33607079
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33086175
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32971447
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31041663
99beta-Alanine metabolism_Homo sapiens_hsa004100.30586304
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30026882

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