SCAMP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.66811617
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.34416091
3locomotory exploration behavior (GO:0035641)5.99160839
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.54232703
5synaptic vesicle exocytosis (GO:0016079)5.34442338
6glutamate secretion (GO:0014047)5.32285139
7* positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.31777825
8vocalization behavior (GO:0071625)5.23044976
9regulation of synaptic vesicle exocytosis (GO:2000300)5.07167504
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.97591477
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.92076916
12layer formation in cerebral cortex (GO:0021819)4.78028987
13regulation of glutamate receptor signaling pathway (GO:1900449)4.66258577
14protein localization to synapse (GO:0035418)4.62380501
15exploration behavior (GO:0035640)4.54489815
16regulation of synaptic vesicle transport (GO:1902803)4.48546305
17neurotransmitter secretion (GO:0007269)4.48525442
18regulation of neuronal synaptic plasticity (GO:0048168)4.45449452
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.34603888
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.32403816
21neuron cell-cell adhesion (GO:0007158)4.28137638
22regulation of synapse structural plasticity (GO:0051823)4.26797532
23cellular potassium ion homeostasis (GO:0030007)4.25280603
24sodium ion export (GO:0071436)4.24587040
25gamma-aminobutyric acid transport (GO:0015812)4.20532666
26regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.17244342
27neuronal action potential propagation (GO:0019227)4.15797490
28dendritic spine morphogenesis (GO:0060997)4.12269811
29neurotransmitter-gated ion channel clustering (GO:0072578)4.00109688
30synaptic transmission, glutamatergic (GO:0035249)3.99319040
31axon ensheathment in central nervous system (GO:0032291)3.99186157
32central nervous system myelination (GO:0022010)3.99186157
33amino acid import (GO:0043090)3.98495226
34proline transport (GO:0015824)3.97715824
35regulation of synapse maturation (GO:0090128)3.85553520
36long-term memory (GO:0007616)3.83885000
37glutamate receptor signaling pathway (GO:0007215)3.82390561
38positive regulation of dendritic spine morphogenesis (GO:0061003)3.81445721
39regulation of voltage-gated calcium channel activity (GO:1901385)3.76884086
40neuron-neuron synaptic transmission (GO:0007270)3.72620989
41positive regulation of membrane potential (GO:0045838)3.69093870
42neurotransmitter transport (GO:0006836)3.68068251
43glycine transport (GO:0015816)3.66003111
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.65683915
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63938002
46neuromuscular process controlling balance (GO:0050885)3.63801666
47activation of protein kinase A activity (GO:0034199)3.60349641
48positive regulation of synapse maturation (GO:0090129)3.59957674
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57005269
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56268197
51dendrite morphogenesis (GO:0048813)3.53233823
52negative regulation of dendrite morphogenesis (GO:0050774)3.50280749
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.49514940
54synaptic vesicle endocytosis (GO:0048488)3.49242998
55regulation of synaptic plasticity (GO:0048167)3.43697827
56regulation of postsynaptic membrane potential (GO:0060078)3.42759737
57neuron recognition (GO:0008038)3.42672862
58neuromuscular process controlling posture (GO:0050884)3.42259878
59cell communication by electrical coupling (GO:0010644)3.41777250
60transmission of nerve impulse (GO:0019226)3.38485111
61regulation of dendritic spine morphogenesis (GO:0061001)3.37866351
62presynaptic membrane organization (GO:0097090)3.37864221
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37458015
64regulation of neurotransmitter secretion (GO:0046928)3.37038240
65regulation of neurotransmitter levels (GO:0001505)3.36842833
66auditory behavior (GO:0031223)3.32982081
67response to auditory stimulus (GO:0010996)3.31560410
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.31378343
69cerebellar Purkinje cell differentiation (GO:0021702)3.29982314
70presynaptic membrane assembly (GO:0097105)3.26948387
71establishment of mitochondrion localization (GO:0051654)3.26816313
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26642313
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25983809
74neuromuscular synaptic transmission (GO:0007274)3.22809584
75axonal fasciculation (GO:0007413)3.20974282
76L-amino acid import (GO:0043092)3.18879637
77cell differentiation in hindbrain (GO:0021533)3.18678513
78prepulse inhibition (GO:0060134)3.17837516
79long-term synaptic potentiation (GO:0060291)3.16156310
80regulation of ARF protein signal transduction (GO:0032012)3.15493535
81membrane hyperpolarization (GO:0060081)3.15481870
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.14973462
83regulation of synaptic transmission, glutamatergic (GO:0051966)3.14591365
84neuronal ion channel clustering (GO:0045161)3.14511229
85vesicle transport along microtubule (GO:0047496)3.13584810
86regulation of neurotransmitter transport (GO:0051588)3.13365562
87regulation of vesicle fusion (GO:0031338)3.10551035
88cerebellar Purkinje cell layer development (GO:0021680)3.09573113
89synaptic transmission (GO:0007268)3.08227416
90chemosensory behavior (GO:0007635)3.04633897
91potassium ion import (GO:0010107)3.04301587
92establishment of synaptic vesicle localization (GO:0097480)3.03847096
93synaptic vesicle transport (GO:0048489)3.03847096
94innervation (GO:0060384)3.03740986
95postsynaptic membrane organization (GO:0001941)3.01720513
96acidic amino acid transport (GO:0015800)3.01351943
97gamma-aminobutyric acid signaling pathway (GO:0007214)3.01109964
98cell migration in hindbrain (GO:0021535)2.99461304
99adult walking behavior (GO:0007628)2.99172116
100neuromuscular process (GO:0050905)2.98814652
101positive regulation of dendritic spine development (GO:0060999)2.98594813
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97002420
103positive regulation of neurotransmitter transport (GO:0051590)2.96943416
104mating behavior (GO:0007617)2.96426526
105dendritic spine organization (GO:0097061)2.96134071
106potassium ion homeostasis (GO:0055075)2.95726209
107organelle transport along microtubule (GO:0072384)2.94514205
108membrane depolarization (GO:0051899)2.94004969
109negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93393994
110learning (GO:0007612)2.91684466
111G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90884227
112synapse assembly (GO:0007416)2.90746330
113cerebellar granule cell differentiation (GO:0021707)2.90203562
114membrane depolarization during action potential (GO:0086010)2.89997548
115cellular sodium ion homeostasis (GO:0006883)2.88805861
116positive regulation of synaptic transmission (GO:0050806)2.88626427
117regulation of synaptic transmission (GO:0050804)2.88596683
118positive regulation of neurotransmitter secretion (GO:0001956)2.87674668
119regulation of dendritic spine development (GO:0060998)2.85913440

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.52092641
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03125857
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98152199
4GBX2_23144817_ChIP-Seq_PC3_Human2.97321113
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87497013
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.81154291
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.79803530
8DROSHA_22980978_ChIP-Seq_HELA_Human2.76113168
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69670157
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69670157
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58102525
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57935074
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55046710
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45010618
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43119118
16* REST_18959480_ChIP-ChIP_MESCs_Mouse2.37443527
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36394997
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.34669025
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33228666
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.30856060
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30757448
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30567873
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26093828
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19211021
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.17302137
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13719785
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.07983844
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03052915
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00746938
30AR_21572438_ChIP-Seq_LNCaP_Human1.87520369
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.79094630
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71410452
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47819475
34* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45896071
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44230184
36KDM2B_26808549_Chip-Seq_K562_Human1.42721524
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40726341
38* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39498304
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.38955767
40SMAD4_21799915_ChIP-Seq_A2780_Human1.37128387
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28380572
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27768283
43WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27406890
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.26326904
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26152842
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25843178
47ZNF274_21170338_ChIP-Seq_K562_Hela1.25746105
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.25717849
49AR_19668381_ChIP-Seq_PC3_Human1.24177538
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22125478
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22007889
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19806244
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.19680100
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19615910
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18841765
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13496883
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13304305
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12029010
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11797665
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11434487
61STAT3_23295773_ChIP-Seq_U87_Human1.11339581
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09591858
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08449225
64LXR_22292898_ChIP-Seq_THP-1_Human1.05809069
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.05667934
66* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05394682
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03368809
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03360647
69AR_25329375_ChIP-Seq_VCAP_Human1.03106484
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02266089
71TET1_21490601_ChIP-Seq_MESCs_Mouse1.01847191
72* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01680256
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00865500
74OCT4_19829295_ChIP-Seq_ESCs_Human0.99939430
75TAF15_26573619_Chip-Seq_HEK293_Human0.99840646
76TP53_20018659_ChIP-ChIP_R1E_Mouse0.99636426
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99574771
78YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99523631
79CTCF_27219007_Chip-Seq_Bcells_Human0.98449008
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97713279
81SMAD4_21741376_ChIP-Seq_HESCs_Human0.97311034
82SMAD3_21741376_ChIP-Seq_ESCs_Human0.96397430
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96256128
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96110568
85BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95539275
86ARNT_22903824_ChIP-Seq_MCF-7_Human0.94671582
87SMAD3_21741376_ChIP-Seq_HESCs_Human0.94608182
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94217563
89P300_19829295_ChIP-Seq_ESCs_Human0.93824050
90DPY_21335234_ChIP-Seq_ESCs_Mouse0.93793601
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93687201
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93489221
93SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93326827
94AHR_22903824_ChIP-Seq_MCF-7_Human0.93199157
95TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92695046
96TCF4_23295773_ChIP-Seq_U87_Human0.92449929
97SMC4_20622854_ChIP-Seq_HELA_Human0.92049639
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91569651
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91249922
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.90198454
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89367831
102IGF1R_20145208_ChIP-Seq_DFB_Human0.88411450
103CBX2_27304074_Chip-Seq_ESCs_Mouse0.88076232
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.87676555
105KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84492667
106ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84241300
107PIAS1_25552417_ChIP-Seq_VCAP_Human0.84119950
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83804078
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83465170
110* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82597885
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82162858
112CREB1_26743006_Chip-Seq_LNCaP_Human0.81998731
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81339594
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81297289
115KLF4_19829295_ChIP-Seq_ESCs_Human0.81236825
116RNF2_27304074_Chip-Seq_NSC_Mouse0.80580286
117RXR_22108803_ChIP-Seq_LS180_Human0.80300797
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79857516
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79572589
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.79481762
121RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79333441
122SMAD4_21741376_ChIP-Seq_ESCs_Human0.77541727
123NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.74921405
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73385943
125P68_20966046_ChIP-Seq_HELA_Human0.71208064
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71008039
127MYC_19915707_ChIP-ChIP_AK7_Human0.68235971
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.68023302
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68023302

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.74291046
2MP0003880_abnormal_central_pattern4.35472819
3MP0003635_abnormal_synaptic_transmissio4.15736799
4MP0004270_analgesia3.96153685
5MP0002063_abnormal_learning/memory/cond3.28166519
6MP0009745_abnormal_behavioral_response3.27693732
7MP0005423_abnormal_somatic_nervous3.24059722
8MP0002064_seizures3.17328414
9MP0009046_muscle_twitch3.05594621
10MP0001968_abnormal_touch/_nociception2.76881091
11MP0002734_abnormal_mechanical_nocicepti2.71136545
12MP0002572_abnormal_emotion/affect_behav2.69401945
13MP0002822_catalepsy2.65010862
14MP0001486_abnormal_startle_reflex2.62737615
15MP0002272_abnormal_nervous_system2.56220166
16MP0003329_amyloid_beta_deposits2.16182075
17MP0009780_abnormal_chondrocyte_physiolo2.12986815
18MP0002733_abnormal_thermal_nociception2.10346277
19MP0001440_abnormal_grooming_behavior2.06511912
20MP0001501_abnormal_sleep_pattern2.04157343
21MP0008569_lethality_at_weaning2.02131874
22MP0004858_abnormal_nervous_system2.02086889
23MP0002736_abnormal_nociception_after1.99664384
24MP0001970_abnormal_pain_threshold1.99622683
25MP0003123_paternal_imprinting1.97648716
26MP0004885_abnormal_endolymph1.96965826
27MP0002735_abnormal_chemical_nociception1.93060524
28MP0002067_abnormal_sensory_capabilities1.87853243
29MP0000778_abnormal_nervous_system1.87452705
30MP0004811_abnormal_neuron_physiology1.87330015
31MP0002909_abnormal_adrenal_gland1.86645289
32MP0002184_abnormal_innervation1.74452519
33MP0002557_abnormal_social/conspecific_i1.71460495
34MP0004924_abnormal_behavior1.70371043
35MP0005386_behavior/neurological_phenoty1.70371043
36MP0000955_abnormal_spinal_cord1.69306660
37MP0002882_abnormal_neuron_morphology1.56301422
38MP0005551_abnormal_eye_electrophysiolog1.54806074
39MP0003633_abnormal_nervous_system1.48872396
40MP0002066_abnormal_motor_capabilities/c1.47241250
41MP0005646_abnormal_pituitary_gland1.45600378
42MP0003879_abnormal_hair_cell1.41103772
43MP0001984_abnormal_olfaction1.35026475
44MP0001502_abnormal_circadian_rhythm1.31900887
45MP0004142_abnormal_muscle_tone1.30960641
46MP0003631_nervous_system_phenotype1.27636276
47MP0006276_abnormal_autonomic_nervous1.27440898
48MP0002229_neurodegeneration1.26564778
49MP0003690_abnormal_glial_cell1.25874138
50MP0000920_abnormal_myelination1.25817367
51MP0003283_abnormal_digestive_organ1.22824748
52MP0003634_abnormal_glial_cell1.19922616
53MP0003787_abnormal_imprinting1.18340856
54MP0005645_abnormal_hypothalamus_physiol1.17191488
55MP0002152_abnormal_brain_morphology1.16909247
56MP0001905_abnormal_dopamine_level1.13280267
57MP0001529_abnormal_vocalization1.12232971
58MP0000569_abnormal_digit_pigmentation1.10582042
59MP0002090_abnormal_vision1.08418115
60MP0003632_abnormal_nervous_system1.04381360
61MP0000604_amyloidosis1.04291724
62MP0003122_maternal_imprinting1.02400062
63MP0003075_altered_response_to1.01132012
64MP0008961_abnormal_basal_metabolism1.00675965
65MP0003121_genomic_imprinting0.99829781
66MP0003172_abnormal_lysosome_physiology0.98975953
67MP0001188_hyperpigmentation0.95708061
68MP0002069_abnormal_eating/drinking_beha0.94661039
69MP0001177_atelectasis0.93652148
70MP0008872_abnormal_physiological_respon0.93614463
71MP0004742_abnormal_vestibular_system0.88586469
72MP0000013_abnormal_adipose_tissue0.88572733
73MP0008877_abnormal_DNA_methylation0.88562885
74MP0000751_myopathy0.86959345
75MP0004145_abnormal_muscle_electrophysio0.86831675
76MP0002752_abnormal_somatic_nervous0.85767113
77MP0006072_abnormal_retinal_apoptosis0.84566355
78MP0004233_abnormal_muscle_weight0.83033656
79MP0008874_decreased_physiological_sensi0.81651317
80MP0004043_abnormal_pH_regulation0.80959623
81MP0005253_abnormal_eye_physiology0.80233978
82MP0001963_abnormal_hearing_physiology0.78149019
83MP0005535_abnormal_body_temperature0.75817173
84MP0010386_abnormal_urinary_bladder0.75435290
85MP0005499_abnormal_olfactory_system0.75391695
86MP0005394_taste/olfaction_phenotype0.75391695
87MP0001986_abnormal_taste_sensitivity0.75087664
88MP0004085_abnormal_heartbeat0.74760154
89MP0001348_abnormal_lacrimal_gland0.74612346
90MP0001346_abnormal_lacrimal_gland0.73824349
91MP0002638_abnormal_pupillary_reflex0.73436285
92MP0002653_abnormal_ependyma_morphology0.72903293
93MP0000631_abnormal_neuroendocrine_gland0.72217918
94MP0001299_abnormal_eye_distance/0.70559090
95MP0004147_increased_porphyrin_level0.70236984
96MP0005167_abnormal_blood-brain_barrier0.70107649
97MP0003137_abnormal_impulse_conducting0.67678744
98MP0005623_abnormal_meninges_morphology0.67154331
99MP0004130_abnormal_muscle_cell0.63351903
100MP0003861_abnormal_nervous_system0.61270283
101MP0001664_abnormal_digestion0.58792452
102MP0000026_abnormal_inner_ear0.57754503
103MP0003938_abnormal_ear_development0.57673091
104MP0001485_abnormal_pinna_reflex0.57561670
105MP0010768_mortality/aging0.56419458
106MP0005409_darkened_coat_color0.56337666
107MP0010769_abnormal_survival0.55011312
108MP0005187_abnormal_penis_morphology0.54947778
109MP0000566_synostosis0.54921424
110MP0000747_muscle_weakness0.54278723
111MP0001943_abnormal_respiration0.53847985
112MP0005195_abnormal_posterior_eye0.53006176
113MP0003956_abnormal_body_size0.52541410
114MP0002082_postnatal_lethality0.51896955
115MP0010770_preweaning_lethality0.51896955

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.93153761
2Focal motor seizures (HP:0011153)6.35413649
3Focal seizures (HP:0007359)5.18381182
4Visual hallucinations (HP:0002367)5.12154794
5Action tremor (HP:0002345)4.39103345
6Epileptic encephalopathy (HP:0200134)4.29636680
7Supranuclear gaze palsy (HP:0000605)4.19255309
8Progressive cerebellar ataxia (HP:0002073)4.10426325
9Ankle clonus (HP:0011448)4.04746135
10Mutism (HP:0002300)3.64336041
11Atonic seizures (HP:0010819)3.62593308
12Febrile seizures (HP:0002373)3.59270903
13Absence seizures (HP:0002121)3.54272384
14Generalized tonic-clonic seizures (HP:0002069)3.47587312
15Depression (HP:0000716)3.37380033
16Cerebral hypomyelination (HP:0006808)3.31073605
17Neurofibrillary tangles (HP:0002185)3.29487997
18Dysdiadochokinesis (HP:0002075)3.27153602
19Dialeptic seizures (HP:0011146)3.26061742
20Postural instability (HP:0002172)3.24446624
21Poor eye contact (HP:0000817)3.20182493
22Dysmetria (HP:0001310)3.17139399
23Urinary bladder sphincter dysfunction (HP:0002839)3.15478063
24Papilledema (HP:0001085)3.14746359
25Impaired vibration sensation in the lower limbs (HP:0002166)3.13218387
26Broad-based gait (HP:0002136)3.12227820
27Abnormality of the lower motor neuron (HP:0002366)3.07058932
28Intention tremor (HP:0002080)3.04734007
29Abnormal social behavior (HP:0012433)3.00271627
30Impaired social interactions (HP:0000735)3.00271627
31Cerebral inclusion bodies (HP:0100314)2.99033142
32Abnormal eating behavior (HP:0100738)2.98722275
33Gaze-evoked nystagmus (HP:0000640)2.94720718
34Spastic gait (HP:0002064)2.93972938
35Anxiety (HP:0000739)2.89882869
36Truncal ataxia (HP:0002078)2.88682919
37Urinary urgency (HP:0000012)2.85873605
38Torticollis (HP:0000473)2.83640968
39Genetic anticipation (HP:0003743)2.80737351
40Abnormality of the corticospinal tract (HP:0002492)2.75937038
41Hemiparesis (HP:0001269)2.74224777
42Megalencephaly (HP:0001355)2.73030853
43Sleep apnea (HP:0010535)2.63065965
44Termporal pattern (HP:0011008)2.62274875
45Insidious onset (HP:0003587)2.62274875
46Hemiplegia (HP:0002301)2.58956186
47Scanning speech (HP:0002168)2.58753685
48Focal dystonia (HP:0004373)2.56302605
49Delusions (HP:0000746)2.54022088
50Impaired smooth pursuit (HP:0007772)2.53062128
51Abnormality of binocular vision (HP:0011514)2.52651943
52Diplopia (HP:0000651)2.52651943
53Drooling (HP:0002307)2.51564780
54Excessive salivation (HP:0003781)2.51564780
55Bradykinesia (HP:0002067)2.50011863
56Limb dystonia (HP:0002451)2.45557761
57Ventricular fibrillation (HP:0001663)2.43053167
58Amblyopia (HP:0000646)2.40297521
59Lower limb muscle weakness (HP:0007340)2.39699490
60Insomnia (HP:0100785)2.38915271
61Pheochromocytoma (HP:0002666)2.37143808
62Progressive inability to walk (HP:0002505)2.36098893
63Craniofacial dystonia (HP:0012179)2.31716821
64Hyperventilation (HP:0002883)2.31694637
65Clonus (HP:0002169)2.30897694
66Abnormality of ocular smooth pursuit (HP:0000617)2.30188378
67Amyotrophic lateral sclerosis (HP:0007354)2.28188772
68Epileptiform EEG discharges (HP:0011182)2.27496510
69EEG with generalized epileptiform discharges (HP:0011198)2.26485667
70Neuronal loss in central nervous system (HP:0002529)2.24125268
71Diminished motivation (HP:0000745)2.23139721
72Stereotypic behavior (HP:0000733)2.22381143
73Hypsarrhythmia (HP:0002521)2.20379975
74Status epilepticus (HP:0002133)2.20321328
75Agitation (HP:0000713)2.19226755
76Annular pancreas (HP:0001734)2.17271708
77CNS hypomyelination (HP:0003429)2.16816605
78Choreoathetosis (HP:0001266)2.15128995
79Dysmetric saccades (HP:0000641)2.10492151
80Generalized myoclonic seizures (HP:0002123)2.10403279
81Impaired vibratory sensation (HP:0002495)2.10105845
82Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.08056686
83Degeneration of the lateral corticospinal tracts (HP:0002314)2.08056686
84Central scotoma (HP:0000603)2.05575879
85Pointed chin (HP:0000307)2.04738849
86Polyphagia (HP:0002591)2.04217815
87Fetal akinesia sequence (HP:0001989)2.03984308
88Obstructive sleep apnea (HP:0002870)2.03709148
89Rigidity (HP:0002063)2.00355217
90Absent speech (HP:0001344)1.98439834
91Apathy (HP:0000741)1.94470711
92Akinesia (HP:0002304)1.94438129
93Gait ataxia (HP:0002066)1.94431576
94Peripheral hypomyelination (HP:0007182)1.93576997
95Neuroendocrine neoplasm (HP:0100634)1.92522989
96Increased circulating renin level (HP:0000848)1.90444987
97Rapidly progressive (HP:0003678)1.88721507
98Spastic tetraparesis (HP:0001285)1.87865361
99Aplasia involving bones of the upper limbs (HP:0009823)1.87336564
100Aplasia of the phalanges of the hand (HP:0009802)1.87336564
101Aplasia involving bones of the extremities (HP:0009825)1.87336564
102Spastic tetraplegia (HP:0002510)1.86995416
103Bundle branch block (HP:0011710)1.86922926
104Morphological abnormality of the pyramidal tract (HP:0002062)1.86584299
105Abnormality of saccadic eye movements (HP:0000570)1.84870701
106Postural tremor (HP:0002174)1.84860180
107Tetraplegia (HP:0002445)1.82830712
108Lower limb asymmetry (HP:0100559)1.82167334
109Turricephaly (HP:0000262)1.81477306
110Incomplete penetrance (HP:0003829)1.80793766
111Congenital stationary night blindness (HP:0007642)1.80696698
112Inappropriate behavior (HP:0000719)1.78666529
113Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77912810
114Spinal canal stenosis (HP:0003416)1.77535471
115Resting tremor (HP:0002322)1.76979591
116Bronchomalacia (HP:0002780)1.76845296
117Psychosis (HP:0000709)1.74906450

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.14392704
2NTRK33.92055257
3MARK13.85767639
4EPHA43.66829769
5MAP3K42.76222318
6MINK12.74776104
7PAK62.64643746
8DAPK22.42958243
9PRKD32.42228145
10KSR22.29910401
11NTRK22.25307087
12NTRK12.07540760
13CAMKK12.05416985
14MAP2K71.98064439
15MAP2K41.68288238
16CDK51.62775719
17KSR11.60855993
18TYRO31.54469917
19STK381.46040765
20PHKG11.39864112
21PHKG21.39864112
22MAP3K21.36501469
23UHMK11.35812663
24GRK51.32052834
25CDK191.29238249
26SIK21.25858412
27PRPF4B1.25257472
28DAPK11.21853727
29MAPK131.17590212
30MAP3K121.15006966
31PRKCG1.14460500
32LATS21.11659569
33PLK21.10900156
34TAOK11.10139669
35RIPK41.08960747
36TNIK1.06107562
37CAMKK21.05464708
38CDK151.03960583
39CDK181.03606347
40ALK1.03389748
41PNCK1.02467602
42ARAF1.01859514
43SGK4941.01453364
44SGK2231.01453364
45PRKCH1.00907960
46CDK141.00168648
47LMTK20.99993739
48FES0.97357730
49RET0.96602181
50PINK10.96482395
51STK110.95989166
52CDK11A0.90643484
53MAP3K130.90484872
54CSNK1G20.89415896
55OXSR10.88698464
56PAK30.88693049
57CAMK10.86965748
58RIPK10.85711283
59CAMK2A0.85599486
60MARK20.85393726
61CASK0.82620839
62SCYL20.78140147
63NEK10.73551328
64CAMK2B0.72835504
65MAP3K110.71904000
66MAPK120.70613157
67DYRK1A0.68693178
68BRAF0.67361500
69PDK10.67065281
70CAMK1D0.66839304
71PDPK10.63927229
72SGK30.63398445
73SGK10.62542181
74WNK10.62170786
75PRKCZ0.61447715
76ICK0.61029167
77CAMK1G0.60411592
78DYRK20.60268333
79RAF10.59783791
80MAP3K10.56460721
81SGK20.53985218
82RPS6KA30.53377727
83CDC42BPA0.53357817
84PKN10.52650151
85FYN0.52422411
86NEK60.52188120
87MAPK100.48448247
88CAMK2D0.46802275
89CAMK2G0.46275843
90LIMK10.46006467
91CAMK40.45785592
92BRSK10.44336752
93MAP3K70.44275635
94FGFR20.43998325
95PTK2B0.43174595
96WNK30.43169145
97PRKCE0.39748451
98STK390.39457732
99DAPK30.38061930
100ROCK20.36819283
101TESK10.36237249
102TNK20.36086477
103DDR20.35849308
104CSNK1G30.35402457
105ERBB20.35143373
106RPS6KA20.34178642
107DMPK0.32904341
108MAPKAPK50.32346164
109CSNK1E0.32086598
110PRKCA0.31938900
111MAPK80.29879813
112PRKG20.27907525
113CSNK1D0.26487428
114IRAK20.25784115

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.38257904
2Nicotine addiction_Homo sapiens_hsa050333.27956443
3GABAergic synapse_Homo sapiens_hsa047272.72751884
4Olfactory transduction_Homo sapiens_hsa047402.67466255
5Circadian entrainment_Homo sapiens_hsa047132.58127524
6Glutamatergic synapse_Homo sapiens_hsa047242.50698817
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.44262155
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44177818
9Long-term potentiation_Homo sapiens_hsa047202.40330888
10Morphine addiction_Homo sapiens_hsa050322.36187093
11Amphetamine addiction_Homo sapiens_hsa050312.21763584
12Dopaminergic synapse_Homo sapiens_hsa047282.10136249
13Salivary secretion_Homo sapiens_hsa049702.06478661
14Insulin secretion_Homo sapiens_hsa049112.00685977
15Cholinergic synapse_Homo sapiens_hsa047251.92831731
16Nitrogen metabolism_Homo sapiens_hsa009101.90009289
17Gastric acid secretion_Homo sapiens_hsa049711.89097362
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76518031
19Vitamin B6 metabolism_Homo sapiens_hsa007501.69348367
20Cocaine addiction_Homo sapiens_hsa050301.67974385
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66843767
22Phototransduction_Homo sapiens_hsa047441.64552382
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59088559
24Long-term depression_Homo sapiens_hsa047301.58110504
25Oxytocin signaling pathway_Homo sapiens_hsa049211.52281565
26Renin secretion_Homo sapiens_hsa049241.50532723
27Serotonergic synapse_Homo sapiens_hsa047261.48501621
28Taste transduction_Homo sapiens_hsa047421.46163863
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45751233
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44145176
31GnRH signaling pathway_Homo sapiens_hsa049121.40044383
32Gap junction_Homo sapiens_hsa045401.35875865
33Calcium signaling pathway_Homo sapiens_hsa040201.33883654
34Type II diabetes mellitus_Homo sapiens_hsa049301.25691407
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22652807
36cAMP signaling pathway_Homo sapiens_hsa040241.20524366
37Collecting duct acid secretion_Homo sapiens_hsa049661.19165379
38Axon guidance_Homo sapiens_hsa043601.17130832
39Estrogen signaling pathway_Homo sapiens_hsa049151.14471783
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11989895
41Glioma_Homo sapiens_hsa052141.11948745
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10466686
43ErbB signaling pathway_Homo sapiens_hsa040121.02686954
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95531807
45Melanogenesis_Homo sapiens_hsa049160.95479711
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.92364985
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92054015
48Dorso-ventral axis formation_Homo sapiens_hsa043200.86341209
49Pancreatic secretion_Homo sapiens_hsa049720.82911557
50Oocyte meiosis_Homo sapiens_hsa041140.82605941
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.82588781
52Vibrio cholerae infection_Homo sapiens_hsa051100.82082816
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82051399
54Thyroid hormone synthesis_Homo sapiens_hsa049180.81054170
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77435192
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75217948
57Cardiac muscle contraction_Homo sapiens_hsa042600.74841020
58Bile secretion_Homo sapiens_hsa049760.74123539
59Choline metabolism in cancer_Homo sapiens_hsa052310.72866641
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.66319138
61Endocytosis_Homo sapiens_hsa041440.66224213
62Dilated cardiomyopathy_Homo sapiens_hsa054140.65871085
63MAPK signaling pathway_Homo sapiens_hsa040100.65056793
64mTOR signaling pathway_Homo sapiens_hsa041500.62270399
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61823753
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61552022
67VEGF signaling pathway_Homo sapiens_hsa043700.61503030
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61181391
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.60913135
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59599454
71Prion diseases_Homo sapiens_hsa050200.57983991
72Ras signaling pathway_Homo sapiens_hsa040140.56303993
73Renal cell carcinoma_Homo sapiens_hsa052110.53786239
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53446139
75Rap1 signaling pathway_Homo sapiens_hsa040150.52313848
76Endometrial cancer_Homo sapiens_hsa052130.51256845
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51141297
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50812944
79Alcoholism_Homo sapiens_hsa050340.50730081
80Fatty acid biosynthesis_Homo sapiens_hsa000610.50631808
81Inositol phosphate metabolism_Homo sapiens_hsa005620.50500595
82Glucagon signaling pathway_Homo sapiens_hsa049220.50310720
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49106856
84Arginine and proline metabolism_Homo sapiens_hsa003300.49086270
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45397423
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45260236
87Circadian rhythm_Homo sapiens_hsa047100.43544424
88Alzheimers disease_Homo sapiens_hsa050100.43153649
89Non-small cell lung cancer_Homo sapiens_hsa052230.41919449
90Insulin signaling pathway_Homo sapiens_hsa049100.41220940
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41134184
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40794792
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38759211
94Type I diabetes mellitus_Homo sapiens_hsa049400.38374366
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37218898
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.37012506
97Wnt signaling pathway_Homo sapiens_hsa043100.35509125
98Ovarian steroidogenesis_Homo sapiens_hsa049130.35298918
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34624213
100AMPK signaling pathway_Homo sapiens_hsa041520.34323249
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33673928
102Chemokine signaling pathway_Homo sapiens_hsa040620.33253758
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32133760
104Butanoate metabolism_Homo sapiens_hsa006500.31561370
105Histidine metabolism_Homo sapiens_hsa003400.30917962
106Mineral absorption_Homo sapiens_hsa049780.30911286
107Arginine biosynthesis_Homo sapiens_hsa002200.30206852
108Tight junction_Homo sapiens_hsa045300.28014096
109Hippo signaling pathway_Homo sapiens_hsa043900.26635803
110beta-Alanine metabolism_Homo sapiens_hsa004100.25468872
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22110550
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19454829

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