SBSPON

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mature B cell differentiation involved in immune response (GO:0002313)9.24990907
2positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc8.98718118
3embryonic skeletal joint morphogenesis (GO:0060272)7.89145300
4negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)7.69270979
5negative regulation of DNA-templated transcription, elongation (GO:0032785)7.69270979
6ectodermal placode formation (GO:0060788)7.39623304
7ribosomal small subunit assembly (GO:0000028)7.37881429
8mature B cell differentiation (GO:0002335)6.50601807
9maturation of SSU-rRNA (GO:0030490)6.30186760
10purine nucleotide salvage (GO:0032261)6.08889118
11positive regulation of peptidyl-threonine phosphorylation (GO:0010800)6.08289561
12dorsal/ventral axis specification (GO:0009950)6.03598227
13negative regulation of dendrite morphogenesis (GO:0050774)5.77042773
14regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:25.65593544
15chaperone mediated protein folding requiring cofactor (GO:0051085)5.50527203
16energy homeostasis (GO:0097009)5.41959737
17Peyers patch development (GO:0048541)5.29015645
18mucosal-associated lymphoid tissue development (GO:0048537)5.29015645
19regulation of catenin import into nucleus (GO:0035412)5.18411594
20positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)5.17718442
21endocardial cushion development (GO:0003197)5.16333236
22mitochondrial calcium ion homeostasis (GO:0051560)4.91381793
23positive regulation of cell cycle G1/S phase transition (GO:1902808)4.77556228
24pinocytosis (GO:0006907)4.72921733
25genetic imprinting (GO:0071514)4.66510551
26negative regulation of dendrite development (GO:2000171)4.62496507
27IMP biosynthetic process (GO:0006188)4.58939636
28valine metabolic process (GO:0006573)4.57626549
29behavioral response to nicotine (GO:0035095)4.57257191
30cellular response to zinc ion (GO:0071294)4.54041803
31embryonic eye morphogenesis (GO:0048048)4.50757989
32ribosome assembly (GO:0042255)4.36543898
33negative regulation of interleukin-8 production (GO:0032717)4.35293562
34detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.27742154
35positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.26505423
36positive regulation of CREB transcription factor activity (GO:0032793)4.26050049
37blood vessel maturation (GO:0001955)4.22981276
38macrophage differentiation (GO:0030225)4.07838967
39branched-chain amino acid catabolic process (GO:0009083)4.04401817
40relaxation of smooth muscle (GO:0044557)3.98386489
41regulation of interleukin-8 biosynthetic process (GO:0045414)3.96944859
42IMP metabolic process (GO:0046040)3.94664848
43post-anal tail morphogenesis (GO:0036342)3.94117347
44cellular response to fluid shear stress (GO:0071498)3.92179542
45ribosomal small subunit biogenesis (GO:0042274)3.91371354
46platelet dense granule organization (GO:0060155)3.87066826
47indolalkylamine metabolic process (GO:0006586)3.86607600
48protein neddylation (GO:0045116)3.83856673
49regulation of peptidyl-threonine phosphorylation (GO:0010799)3.77557921
50indole-containing compound catabolic process (GO:0042436)3.77032671
51indolalkylamine catabolic process (GO:0046218)3.77032671
52tryptophan catabolic process (GO:0006569)3.77032671
53respiratory tube development (GO:0030323)3.69220000
54regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.67211922
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.60196353
56fucose catabolic process (GO:0019317)3.59670789
57L-fucose metabolic process (GO:0042354)3.59670789
58L-fucose catabolic process (GO:0042355)3.59670789
59gland morphogenesis (GO:0022612)3.58554588
603-UTR-mediated mRNA stabilization (GO:0070935)3.58094675
61hematopoietic stem cell differentiation (GO:0060218)3.52613109
62germinal center formation (GO:0002467)3.49901211
63kynurenine metabolic process (GO:0070189)3.49831525
64positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.49354001
65post-embryonic morphogenesis (GO:0009886)3.45648529
66regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.40673269
67branched-chain amino acid metabolic process (GO:0009081)3.38070138
68positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)3.35033615
69detection of light stimulus involved in visual perception (GO:0050908)3.34452099
70detection of light stimulus involved in sensory perception (GO:0050962)3.34452099
71positive regulation of respiratory burst (GO:0060267)3.34105251
72response to host (GO:0075136)3.32584655
73response to host defenses (GO:0052200)3.32584655
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32584655
75regulation of heterotypic cell-cell adhesion (GO:0034114)3.31833455
76tryptophan metabolic process (GO:0006568)3.31798444
77amine catabolic process (GO:0009310)3.29637810
78cellular biogenic amine catabolic process (GO:0042402)3.29637810
79mesodermal cell differentiation (GO:0048333)3.29311689
80dopamine transport (GO:0015872)3.28550544
81photoreceptor cell maintenance (GO:0045494)3.23132467
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.21000780
83response to host immune response (GO:0052572)3.21000780
84response to laminar fluid shear stress (GO:0034616)3.20057345
85inositol phosphate dephosphorylation (GO:0046855)3.17247094
86phosphorylated carbohydrate dephosphorylation (GO:0046838)3.17247094
87mitochondrial calcium ion transport (GO:0006851)3.13526108
88blood coagulation, intrinsic pathway (GO:0007597)3.13336303
89negative regulation of appetite (GO:0032099)3.11748228
90negative regulation of response to food (GO:0032096)3.11748228
91folic acid-containing compound biosynthetic process (GO:0009396)3.10347863
92entrainment of circadian clock by photoperiod (GO:0043153)3.10210125
93definitive hemopoiesis (GO:0060216)3.09645184
94sulfation (GO:0051923)3.09581692
95glomerular visceral epithelial cell development (GO:0072015)3.07314128
96activation of JUN kinase activity (GO:0007257)3.05853013
97regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.05621447
98keratinocyte proliferation (GO:0043616)3.02777124
99positive regulation of mitotic cell cycle phase transition (GO:1901992)3.02749012
100reflex (GO:0060004)3.00611400
101neural tube formation (GO:0001841)2.99671409
102neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.98864082
103regulation of hippo signaling (GO:0035330)2.98851187
104axoneme assembly (GO:0035082)2.98136230
105response to interferon-alpha (GO:0035455)2.97866087
106regulation of translational fidelity (GO:0006450)2.97631784
107viral transcription (GO:0019083)2.96882438
108negative regulation of cytosolic calcium ion concentration (GO:0051481)2.96653900
109indole-containing compound metabolic process (GO:0042430)2.96451784
110tachykinin receptor signaling pathway (GO:0007217)2.95428129
111negative regulation of chondrocyte differentiation (GO:0032331)2.95334422
112regulation of cilium movement (GO:0003352)2.95317601
113positive regulation of cell cycle G2/M phase transition (GO:1902751)2.95104668
114positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.95104668
115regulation of rhodopsin mediated signaling pathway (GO:0022400)2.94508285
116response to growth hormone (GO:0060416)2.94185696
117regulation of synapse maturation (GO:0090128)2.93770393
118rhodopsin mediated signaling pathway (GO:0016056)2.92796977
119epithelial cilium movement (GO:0003351)2.91659599
120piRNA metabolic process (GO:0034587)2.90285213
121detection of mechanical stimulus involved in sensory perception (GO:0050974)2.89961374
122negative regulation of thymocyte apoptotic process (GO:0070244)2.89279961
123positive regulation of cell cycle phase transition (GO:1901989)2.89046196
124cilium morphogenesis (GO:0060271)2.86949783
125kidney morphogenesis (GO:0060993)2.86636756
126negative regulation of cytokine biosynthetic process (GO:0042036)2.86194614
127cytoplasmic microtubule organization (GO:0031122)2.84794199
128cellular ketone body metabolic process (GO:0046950)2.84325654
129neuronal action potential (GO:0019228)2.81063623
130negative regulation of heart rate (GO:0010459)2.80564832
131behavioral response to ethanol (GO:0048149)2.80049713
132signal peptide processing (GO:0006465)2.79593909
133phosphatidylinositol acyl-chain remodeling (GO:0036149)2.79228851
134cilium movement (GO:0003341)2.78035323
135transcription from mitochondrial promoter (GO:0006390)2.76736157
136nonmotile primary cilium assembly (GO:0035058)2.75428009
137inositol phosphate catabolic process (GO:0071545)2.75354936
138gamma-aminobutyric acid transport (GO:0015812)2.73469345
139nucleotide salvage (GO:0043173)2.73264528
140negative regulation of mast cell activation (GO:0033004)2.72367969
141angiogenesis involved in wound healing (GO:0060055)2.69879590
142serotonin metabolic process (GO:0042428)2.69830552
143regulation of axon regeneration (GO:0048679)2.69434842
144regulation of neuron projection regeneration (GO:0070570)2.69434842
145cardiac muscle cell proliferation (GO:0060038)2.68958394
146positive regulation of synapse maturation (GO:0090129)2.67358440
147thrombin receptor signaling pathway (GO:0070493)2.66502579
148cilium organization (GO:0044782)2.66194620
149cellular response to arsenic-containing substance (GO:0071243)2.64763099
150negative regulation of catenin import into nucleus (GO:0035414)2.64510438
151G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64394401
152glomerular epithelial cell development (GO:0072310)2.63431537
153water-soluble vitamin biosynthetic process (GO:0042364)2.63329213
154response to pheromone (GO:0019236)2.62798053
155ketone body metabolic process (GO:1902224)2.62433526
156retinal cone cell development (GO:0046549)2.61761245
157cilium or flagellum-dependent cell motility (GO:0001539)2.61313039
158cilium assembly (GO:0042384)2.60056458
159multicellular organism reproduction (GO:0032504)2.56986129
160aromatic amino acid family catabolic process (GO:0009074)2.56528749
161inner ear receptor stereocilium organization (GO:0060122)2.56484364
162neuronal action potential propagation (GO:0019227)2.55880635
163regulation of gene silencing by RNA (GO:0060966)2.55370777
164regulation of posttranscriptional gene silencing (GO:0060147)2.55370777
165regulation of gene silencing by miRNA (GO:0060964)2.55370777
166primary amino compound metabolic process (GO:1901160)2.54217441
167benzene-containing compound metabolic process (GO:0042537)2.54051433
168male meiosis (GO:0007140)2.49684072
169reciprocal meiotic recombination (GO:0007131)2.48451618
170reciprocal DNA recombination (GO:0035825)2.48451618
171negative regulation of protein localization to cell surface (GO:2000009)2.48114926
172regulation of neurotransmitter uptake (GO:0051580)2.48091713
173regulation of glucokinase activity (GO:0033131)2.46908526
174regulation of hexokinase activity (GO:1903299)2.46908526
175adaptation of signaling pathway (GO:0023058)2.46882753
176regulation of meiosis I (GO:0060631)2.46367235
177mitochondrial respiratory chain complex I assembly (GO:0032981)2.43656859
178NADH dehydrogenase complex assembly (GO:0010257)2.43656859
179mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.43656859
180opioid receptor signaling pathway (GO:0038003)2.42360180
181smooth muscle contraction (GO:0006939)2.41436514
182photoreceptor cell development (GO:0042461)2.40999167
183L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40691667
184positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.40654035
185auditory receptor cell stereocilium organization (GO:0060088)2.40456832
186DNA deamination (GO:0045006)2.38510511
187positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.37245840
188cornea development in camera-type eye (GO:0061303)2.34543182
189protein polyglutamylation (GO:0018095)2.33967611
190DNA methylation involved in gamete generation (GO:0043046)2.33179572
191positive regulation of meiosis (GO:0045836)2.31915186
192transmission of nerve impulse (GO:0019226)2.31578047
193cyclic nucleotide catabolic process (GO:0009214)2.31224813
194positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.30537755
195amino acid salvage (GO:0043102)2.30514594
196L-methionine salvage (GO:0071267)2.30514594
197L-methionine biosynthetic process (GO:0071265)2.30514594
198protein complex biogenesis (GO:0070271)2.30320434
199regulation of collateral sprouting (GO:0048670)2.27911115
200thyroid hormone metabolic process (GO:0042403)2.27504562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.45937112
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.44222622
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.21846153
4SRY_22984422_ChIP-ChIP_TESTIS_Rat3.59130509
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.30347099
6SCL_19346495_ChIP-Seq_HPC-7_Human3.28403969
7VDR_22108803_ChIP-Seq_LS180_Human3.24925537
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.99355045
9ZNF274_21170338_ChIP-Seq_K562_Hela2.96058167
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90962917
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.72822339
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.62773177
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.61483813
14IGF1R_20145208_ChIP-Seq_DFB_Human2.59213615
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51998299
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45058310
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.41080076
18TAF15_26573619_Chip-Seq_HEK293_Human2.39997935
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23148926
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22791016
21AR_21572438_ChIP-Seq_LNCaP_Human2.21109387
22P300_19829295_ChIP-Seq_ESCs_Human2.19940796
23CDX2_20551321_ChIP-Seq_CACO-2_Human2.17955586
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.17281235
25TP53_16413492_ChIP-PET_HCT116_Human2.12365757
26EWS_26573619_Chip-Seq_HEK293_Human2.11240288
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01382885
28CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00754098
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.96999584
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.96871166
31FUS_26573619_Chip-Seq_HEK293_Human1.96513623
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85313743
33SMAD4_21799915_ChIP-Seq_A2780_Human1.82573257
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80266538
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77467434
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77262882
37ER_23166858_ChIP-Seq_MCF-7_Human1.76459354
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75917678
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74097391
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.73682209
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73468806
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68710790
43STAT3_23295773_ChIP-Seq_U87_Human1.65722598
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.64650221
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.63854617
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.62145056
47EZH2_22144423_ChIP-Seq_EOC_Human1.61380514
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58243381
49MYC_22102868_ChIP-Seq_BL_Human1.57354906
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.56778689
51AR_25329375_ChIP-Seq_VCAP_Human1.56303278
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.56052576
53TCF4_23295773_ChIP-Seq_U87_Human1.54986785
54ZNF263_19887448_ChIP-Seq_K562_Human1.54160903
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53916307
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53188489
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51674032
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50467911
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49948907
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49078915
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48244318
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47199994
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.45675317
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45599742
65EGR1_19032775_ChIP-ChIP_M12_Human1.44729266
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44170670
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43731995
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.43133775
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42016421
70PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.41683175
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40616200
72CBP_20019798_ChIP-Seq_JUKART_Human1.40404568
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40404568
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37215886
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36607360
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36493883
77NANOG_19829295_ChIP-Seq_ESCs_Human1.36064999
78SOX2_19829295_ChIP-Seq_ESCs_Human1.36064999
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.35311263
80TCF4_22108803_ChIP-Seq_LS180_Human1.34877200
81SOX2_18692474_ChIP-Seq_MEFs_Mouse1.33919832
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33817194
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.33639997
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.33187326
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32346829
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30505637
87RUNX2_22187159_ChIP-Seq_PCA_Human1.28071642
88RXR_22158963_ChIP-Seq_LIVER_Mouse1.28070433
89IRF1_19129219_ChIP-ChIP_H3396_Human1.27552161
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.27305806
91TP53_22573176_ChIP-Seq_HFKS_Human1.25795171
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24501509
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24501509
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23943006
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.22910358
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21912148
97SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21072953
98RNF2_27304074_Chip-Seq_NSC_Mouse1.21026938
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20580281
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20215755
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.19676045
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19518571
103GBX2_23144817_ChIP-Seq_PC3_Human1.19512050
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18273410
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.17819093
106SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17638498
107P53_22387025_ChIP-Seq_ESCs_Mouse1.17422441
108TP53_20018659_ChIP-ChIP_R1E_Mouse1.16935043
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16299879
110BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15742257
111STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15046099
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14699150
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14660766
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14495286
115MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14448735
116PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13568231
117FLI1_21867929_ChIP-Seq_TH2_Mouse1.13427757
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.13118642
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12945911
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11821950
121CDX2_22108803_ChIP-Seq_LS180_Human1.11729366
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11557073
123ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11376175
124FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09709500
125FOXA1_25329375_ChIP-Seq_VCAP_Human1.09709500
126STAT3_18555785_Chip-Seq_ESCs_Mouse1.09351661
127FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09018615
128FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08898398
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08770636
130FOXO3_23340844_ChIP-Seq_DLD1_Human1.08666431
131E2F1_18555785_Chip-Seq_ESCs_Mouse1.07928333
132SOX2_21211035_ChIP-Seq_LN229_Gbm1.07742219
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07382999
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07096013
135NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07096013
136VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06602632
137WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06362120
138VDR_24763502_ChIP-Seq_THP-1_Human1.05431665
139JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04440798
140ARNT_22903824_ChIP-Seq_MCF-7_Human1.04336605
141PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04120449
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03848764
143JUN_21703547_ChIP-Seq_K562_Human1.03447033
144REST_21632747_ChIP-Seq_MESCs_Mouse1.03027116
145SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02658787
146CBX2_27304074_Chip-Seq_ESCs_Mouse1.02623063
147KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02428710
148GATA3_21878914_ChIP-Seq_MCF-7_Human1.02263321
149LXR_22292898_ChIP-Seq_THP-1_Human1.02007566
150NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01962688
151ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01839524
152SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01481986
153TAL1_26923725_Chip-Seq_HPCs_Mouse1.01283776
154SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01196186
155CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00879858
156KDM2B_26808549_Chip-Seq_REH_Human1.00607088
157OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00492116
158NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00003807
159CJUN_26792858_Chip-Seq_BT549_Human0.99550131
160ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99189096
161GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99075973
162EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98374163
163RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98374163
164WT1_19549856_ChIP-ChIP_CCG9911_Human0.98054696
165SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98023207
166PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97855954
167BCAT_22108803_ChIP-Seq_LS180_Human0.97083855
168ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96772904
169NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96259673
170EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96238970
171TP53_22127205_ChIP-Seq_IMR90_Human0.95263277
172KDM2B_26808549_Chip-Seq_K562_Human0.94613942
173TCF7_22412390_ChIP-Seq_EML_Mouse0.94310404
174PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94054526
175TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93499964
176NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93032905
177KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91864327
178KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90659425
179VDR_21846776_ChIP-Seq_THP-1_Human0.90555705
180CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88005076
181DROSHA_22980978_ChIP-Seq_HELA_Human0.87796499
182GATA1_19941826_ChIP-Seq_K562_Human0.86385843
183RUNX_20019798_ChIP-Seq_JUKART_Human0.85300471
184VDR_24787735_ChIP-Seq_THP-1_Human0.85121844
185EZH2_27304074_Chip-Seq_ESCs_Mouse0.84878401
186MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.83167715

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology7.76494884
2MP0003122_maternal_imprinting5.85887929
3MP0005167_abnormal_blood-brain_barrier5.15110543
4MP0003121_genomic_imprinting3.62315799
5MP0003868_abnormal_feces_composition3.61641936
6MP0003136_yellow_coat_color3.47817590
7MP0008004_abnormal_stomach_pH3.07582072
8MP0002234_abnormal_pharynx_morphology2.70225542
9MP0003195_calcinosis2.68885054
10MP0005551_abnormal_eye_electrophysiolog2.67802677
11MP0002102_abnormal_ear_morphology2.50710215
12MP0003828_pulmonary_edema2.48865508
13MP0008877_abnormal_DNA_methylation2.43508878
14MP0000569_abnormal_digit_pigmentation2.41124672
15MP0009379_abnormal_foot_pigmentation2.40470952
16MP0006276_abnormal_autonomic_nervous2.16928456
17MP0001968_abnormal_touch/_nociception2.09514791
18MP0008872_abnormal_physiological_respon2.00698174
19MP0003123_paternal_imprinting10.7711992
20MP0010386_abnormal_urinary_bladder1.93536416
21MP0000372_irregular_coat_pigmentation1.93326088
22MP0005174_abnormal_tail_pigmentation1.89577380
23MP0005646_abnormal_pituitary_gland1.88595552
24MP0004142_abnormal_muscle_tone1.82865553
25MP0005084_abnormal_gallbladder_morpholo1.81874541
26MP0003942_abnormal_urinary_system1.81443051
27MP0005171_absent_coat_pigmentation1.80386740
28MP0004215_abnormal_myocardial_fiber1.76059249
29MP0002938_white_spotting1.75484107
30MP0004808_abnormal_hematopoietic_stem1.75158146
31MP0003950_abnormal_plasma_membrane1.71564842
32MP0001853_heart_inflammation1.70466147
33MP0009046_muscle_twitch1.69583360
34MP0005253_abnormal_eye_physiology1.68507026
35MP0002735_abnormal_chemical_nociception1.63624235
36MP0003943_abnormal_hepatobiliary_system1.62905849
37MP0000465_gastrointestinal_hemorrhage1.61293507
38MP0004272_abnormal_basement_membrane1.58794085
39MP0001727_abnormal_embryo_implantation1.57807406
40MP0004133_heterotaxia1.56439199
41MP0003191_abnormal_cellular_cholesterol1.56341735
42MP0008875_abnormal_xenobiotic_pharmacok1.52508248
43MP0000383_abnormal_hair_follicle1.52350347
44MP0009745_abnormal_behavioral_response1.51514489
45MP0010368_abnormal_lymphatic_system1.50750704
46MP0002638_abnormal_pupillary_reflex1.50706195
47MP0008775_abnormal_heart_ventricle1.50379354
48MP0006072_abnormal_retinal_apoptosis1.50062991
49MP0001501_abnormal_sleep_pattern1.49423377
50MP0004510_myositis1.48139739
51MP0002736_abnormal_nociception_after1.45681304
52MP0000427_abnormal_hair_cycle1.42340501
53MP0002876_abnormal_thyroid_physiology1.39977151
54MP0004885_abnormal_endolymph1.36163648
55MP0000566_synostosis1.35161744
56MP0005330_cardiomyopathy1.34605917
57MP0000613_abnormal_salivary_gland1.33940619
58MP0005464_abnormal_platelet_physiology1.33277569
59MP0003718_maternal_effect1.29983305
60MP0009697_abnormal_copulation1.29434276
61MP0001984_abnormal_olfaction1.27614399
62MP0005645_abnormal_hypothalamus_physiol1.27577293
63MP0000631_abnormal_neuroendocrine_gland1.26595117
64MP0003011_delayed_dark_adaptation1.25965600
65MP0001529_abnormal_vocalization1.25117029
66MP0003633_abnormal_nervous_system1.23483228
67MP0004043_abnormal_pH_regulation1.22892796
68MP0002572_abnormal_emotion/affect_behav1.22821406
69MP0001664_abnormal_digestion1.21295791
70MP0005410_abnormal_fertilization1.21271015
71MP0003646_muscle_fatigue1.19739142
72MP0002233_abnormal_nose_morphology1.18378742
73MP0001666_abnormal_nutrient_absorption1.18055960
74MP0003566_abnormal_cell_adhesion1.17781918
75MP0004147_increased_porphyrin_level1.17217883
76MP0003880_abnormal_central_pattern1.16876040
77MP0002067_abnormal_sensory_capabilities1.16033101
78MP0003638_abnormal_response/metabolism_1.12939837
79MP0003787_abnormal_imprinting1.12623235
80MP0005195_abnormal_posterior_eye1.06666366
81MP0003252_abnormal_bile_duct1.05507817
82MP0005360_urolithiasis1.04115168
83MP0002557_abnormal_social/conspecific_i1.03637506
84MP0001756_abnormal_urination0.99563811
85MP0002653_abnormal_ependyma_morphology0.98788737
86MP0000428_abnormal_craniofacial_morphol0.98455453
87MP0002160_abnormal_reproductive_system0.96455715
88MP0002734_abnormal_mechanical_nocicepti0.96146014
89MP0005623_abnormal_meninges_morphology0.95415383
90MP0005257_abnormal_intraocular_pressure0.95255957
91MP0000538_abnormal_urinary_bladder0.94370341
92MP0001905_abnormal_dopamine_level0.94199129
93MP0003941_abnormal_skin_development0.93735409
94MP0002138_abnormal_hepatobiliary_system0.93558028
95MP0005386_behavior/neurological_phenoty0.92229888
96MP0004924_abnormal_behavior0.92229888
97MP0005620_abnormal_muscle_contractility0.91443327
98MP0006292_abnormal_olfactory_placode0.90049618
99MP0003119_abnormal_digestive_system0.89607310
100MP0003631_nervous_system_phenotype0.87889363
101MP0002752_abnormal_somatic_nervous0.87671535
102MP0000026_abnormal_inner_ear0.85599326
103MP0006054_spinal_hemorrhage0.85074525
104MP0010329_abnormal_lipoprotein_level0.84279997
105MP0000778_abnormal_nervous_system0.83780167
106MP0002095_abnormal_skin_pigmentation0.83429222
107MP0009278_abnormal_bone_marrow0.83341188
108MP0001324_abnormal_eye_pigmentation0.83050813
109MP0004084_abnormal_cardiac_muscle0.82688991
110MP0004130_abnormal_muscle_cell0.82611055
111MP0005389_reproductive_system_phenotype0.82566008
112MP0003137_abnormal_impulse_conducting0.82175781
113MP0003698_abnormal_male_reproductive0.79904178
114MP0002928_abnormal_bile_duct0.79856736
115MP0003045_fibrosis0.79425516
116MP0004085_abnormal_heartbeat0.78897724
117MP0009780_abnormal_chondrocyte_physiolo0.78656505
118MP0005397_hematopoietic_system_phenotyp0.78488794
119MP0001545_abnormal_hematopoietic_system0.78488794
120MP0004859_abnormal_synaptic_plasticity0.78162466
121MP0002063_abnormal_learning/memory/cond0.77724469
122MP0000762_abnormal_tongue_morphology0.76345449
123MP0005085_abnormal_gallbladder_physiolo0.74093771
124MP0000249_abnormal_blood_vessel0.73395055
125MP0003300_gastrointestinal_ulcer0.73337197
126MP0003937_abnormal_limbs/digits/tail_de0.71140225
127MP0008770_decreased_survivor_rate0.70667893
128MP0002295_abnormal_pulmonary_circulatio0.70500440
129MP0005220_abnormal_exocrine_pancreas0.65725451
130MP0000490_abnormal_crypts_of0.63800987
131MP0005023_abnormal_wound_healing0.62304494
132MP0000639_abnormal_adrenal_gland0.62283153
133MP0000747_muscle_weakness0.62137809
134MP0005503_abnormal_tendon_morphology0.59651254
135MP0002837_dystrophic_cardiac_calcinosis0.59455745
136MP0002932_abnormal_joint_morphology0.58523897
137MP0001879_abnormal_lymphatic_vessel0.57777274
138MP0003635_abnormal_synaptic_transmissio0.56982968
139MP0004270_analgesia0.55334073
140MP0004145_abnormal_muscle_electrophysio0.55212347
141MP0002272_abnormal_nervous_system0.54024498
142MP0005671_abnormal_response_to0.54019124
143MP0002972_abnormal_cardiac_muscle0.50474084
144MP0003866_abnormal_defecation0.50155804
145MP0004036_abnormal_muscle_relaxation0.49624815
146MP0002733_abnormal_thermal_nociception0.48584407
147MP0010234_abnormal_vibrissa_follicle0.48429955
148MP0001970_abnormal_pain_threshold0.47837261
149MP0000516_abnormal_urinary_system0.47823844
150MP0005367_renal/urinary_system_phenotyp0.47823844
151MP0001485_abnormal_pinna_reflex0.47680700
152MP0003075_altered_response_to0.46980934
153MP0009384_cardiac_valve_regurgitation0.46594939
154MP0000920_abnormal_myelination0.46393598
155MP0002139_abnormal_hepatobiliary_system0.46294596
156MP0008438_abnormal_cutaneous_collagen0.46109555
157MP0001943_abnormal_respiration0.45396266
158MP0001963_abnormal_hearing_physiology0.45329415
159MP0005275_abnormal_skin_tensile0.43031088
160MP0002168_other_aberrant_phenotype0.41663132
161MP0003806_abnormal_nucleotide_metabolis0.41537677
162MP0000230_abnormal_systemic_arterial0.40898303
163MP0005388_respiratory_system_phenotype0.39342106
164MP0002133_abnormal_respiratory_system0.39342106
165MP0003385_abnormal_body_wall0.38973750
166MP0000751_myopathy0.38501972
167MP0002064_seizures0.37929783
168MP0001486_abnormal_startle_reflex0.37439916
169MP0008874_decreased_physiological_sensi0.36490858
170MP0000477_abnormal_intestine_morphology0.36284094
171MP0002254_reproductive_system_inflammat0.34447555

Predicted human phenotypes

RankGene SetZ-score
1Micronodular cirrhosis (HP:0001413)7.82620658
2Viral hepatitis (HP:0006562)7.15373504
3Hepatocellular carcinoma (HP:0001402)6.55843679
4Ureteral duplication (HP:0000073)5.35212172
5Menorrhagia (HP:0000132)5.30479941
6Absence seizures (HP:0002121)5.09675360
7Pancreatic cysts (HP:0001737)4.81972633
8Infantile muscular hypotonia (HP:0008947)4.68069432
9Atonic seizures (HP:0010819)4.67414899
10Pancreatic fibrosis (HP:0100732)4.55674494
11True hermaphroditism (HP:0010459)4.48802813
12Ragged-red muscle fibers (HP:0003200)4.33567624
13Progressive inability to walk (HP:0002505)4.33345569
14Congenital stationary night blindness (HP:0007642)4.20863341
15Molar tooth sign on MRI (HP:0002419)4.15290288
16Abnormality of midbrain morphology (HP:0002418)4.15290288
17Febrile seizures (HP:0002373)3.97067344
18Epileptic encephalopathy (HP:0200134)3.95815189
19Dialeptic seizures (HP:0011146)3.79059510
20Nephronophthisis (HP:0000090)3.75484649
21Impaired platelet aggregation (HP:0003540)3.74979099
22Abnormal platelet function (HP:0011869)3.74979099
23Prolonged bleeding time (HP:0003010)3.48677984
24Abnormality of the renal medulla (HP:0100957)3.41339633
25Agitation (HP:0000713)3.39808630
26Increased intramyocellular lipid droplets (HP:0012240)3.35818181
27Cystic liver disease (HP:0006706)3.21844563
28Abnormality of the renal cortex (HP:0011035)3.20695063
29Progressive muscle weakness (HP:0003323)3.18309967
30Attenuation of retinal blood vessels (HP:0007843)3.08713268
31Status epilepticus (HP:0002133)3.08024071
32Chronic hepatic failure (HP:0100626)3.05915649
33Striae distensae (HP:0001065)3.05874000
34Joint hemorrhage (HP:0005261)3.05767162
35Abolished electroretinogram (ERG) (HP:0000550)3.02798062
36Neoplasm of the liver (HP:0002896)2.98571566
37Decreased central vision (HP:0007663)2.98539986
38Mitral valve prolapse (HP:0001634)2.96186762
39Medial flaring of the eyebrow (HP:0010747)2.95518463
40Increased corneal curvature (HP:0100692)2.92316341
41Keratoconus (HP:0000563)2.92316341
42Hemiparesis (HP:0001269)2.87162803
43Hyperventilation (HP:0002883)2.84688224
44Increased muscle lipid content (HP:0009058)2.78659084
45Tubular atrophy (HP:0000092)2.78591930
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.77526073
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.77526073
48Broad-based gait (HP:0002136)2.77054409
49Cortical visual impairment (HP:0100704)2.74588865
50Septate vagina (HP:0001153)2.72816665
51Abnormality of alanine metabolism (HP:0010916)2.71411989
52Hyperalaninemia (HP:0003348)2.71411989
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71411989
54Abnormality of the intrinsic pathway (HP:0010989)2.70943063
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.69679548
56Type II lissencephaly (HP:0007260)2.69461637
57Sclerocornea (HP:0000647)2.69332130
58Neonatal short-limb short stature (HP:0008921)2.67885635
59Progressive cerebellar ataxia (HP:0002073)2.63609325
60Gaze-evoked nystagmus (HP:0000640)2.63317317
61Hydroureter (HP:0000072)2.63211324
62Delayed CNS myelination (HP:0002188)2.62066001
63Ulnar claw (HP:0001178)2.58584699
64Hepatitis (HP:0012115)2.58016629
65Macroorchidism (HP:0000053)2.57435245
66Aortic aneurysm (HP:0004942)2.52550511
67Aplasia/Hypoplasia of the tibia (HP:0005772)2.50158649
68Abnormal drinking behavior (HP:0030082)2.49069136
69Polydipsia (HP:0001959)2.49069136
70Retinal dysplasia (HP:0007973)2.48272636
71Congenital sensorineural hearing impairment (HP:0008527)2.44861351
72Pendular nystagmus (HP:0012043)2.44573527
73Inability to walk (HP:0002540)2.43675040
74Furrowed tongue (HP:0000221)2.43101462
75Congenital, generalized hypertrichosis (HP:0004540)2.42385026
76Plagiocephaly (HP:0001357)2.41746745
77Anencephaly (HP:0002323)2.41404347
78Visual hallucinations (HP:0002367)2.40920188
79Congenital hepatic fibrosis (HP:0002612)2.40680010
80Fair hair (HP:0002286)2.40607751
81Genetic anticipation (HP:0003743)2.38203302
82Lissencephaly (HP:0001339)2.37831712
83Abnormal ciliary motility (HP:0012262)2.37747704
84Gastrointestinal dysmotility (HP:0002579)2.36932985
85Large for gestational age (HP:0001520)2.36197394
86Gait imbalance (HP:0002141)2.35841137
87Optic nerve hypoplasia (HP:0000609)2.35009453
88Poor head control (HP:0002421)2.33687631
89Abnormal rod and cone electroretinograms (HP:0008323)2.32921293
90Clumsiness (HP:0002312)2.32737610
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.32407351
92Chorioretinal atrophy (HP:0000533)2.28538848
93Thyroid-stimulating hormone excess (HP:0002925)2.27411386
94Absent speech (HP:0001344)2.26031282
95Abnormal biliary tract physiology (HP:0012439)2.25061242
96Bile duct proliferation (HP:0001408)2.25061242
97Congenital primary aphakia (HP:0007707)2.24904151
98Protrusio acetabuli (HP:0003179)2.24804518
99Male pseudohermaphroditism (HP:0000037)2.23345187
100Testicular atrophy (HP:0000029)2.21046291
101Dynein arm defect of respiratory motile cilia (HP:0012255)2.20800009
102Absent/shortened dynein arms (HP:0200106)2.20800009
103Increased hepatocellular lipid droplets (HP:0006565)2.19280577
104Renal cortical cysts (HP:0000803)2.19200930
105Hypoplastic left heart (HP:0004383)2.18821300
106Nephrogenic diabetes insipidus (HP:0009806)2.18278093
107Genital tract atresia (HP:0001827)2.18040657
108Thrombocytosis (HP:0001894)2.17904225
109Increased mean platelet volume (HP:0011877)2.17388669
110Bony spicule pigmentary retinopathy (HP:0007737)2.15225175
111Impaired social interactions (HP:0000735)2.14497146
112Abnormal social behavior (HP:0012433)2.14497146
113Purpura (HP:0000979)2.13742495
114Vaginal atresia (HP:0000148)2.09783464
115Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09549859
116Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08513151
117Polyuria (HP:0000103)2.07061821
118Impaired proprioception (HP:0010831)2.06926283
119Action tremor (HP:0002345)2.06382991
120Somatic mutation (HP:0001428)2.05986505
121Poor eye contact (HP:0000817)2.04904629
122Postaxial foot polydactyly (HP:0001830)2.03846369
123Cerebellar dysplasia (HP:0007033)2.03322052
124Occipital encephalocele (HP:0002085)2.01716712
125Subacute progressive viral hepatitis (HP:0006572)12.1714058
126Abnormality of the labia minora (HP:0012880)1.99723615
127Protruding tongue (HP:0010808)1.98362616
128Termporal pattern (HP:0011008)1.96486091
129Insidious onset (HP:0003587)1.96486091
130Hyperlipoproteinemia (HP:0010980)1.94520505
131Aplasia/Hypoplasia of the fovea (HP:0008060)1.93025495
132Hypoplasia of the fovea (HP:0007750)1.93025495
133Generalized myoclonic seizures (HP:0002123)1.92849181
134Lipid accumulation in hepatocytes (HP:0006561)1.92610885
135Abnormal respiratory motile cilium morphology (HP:0005938)1.92532116
136Abnormal respiratory epithelium morphology (HP:0012253)1.92532116
137Polyphagia (HP:0002591)1.92007942
138Inappropriate behavior (HP:0000719)1.91918662
139Abnormal respiratory motile cilium physiology (HP:0012261)1.90725394
140Widely spaced teeth (HP:0000687)1.89976382
141Vaginal fistula (HP:0004320)1.85722306
1423-Methylglutaconic aciduria (HP:0003535)1.85629505
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84207277
144Asymmetric septal hypertrophy (HP:0001670)1.84086253
145Pachygyria (HP:0001302)1.83768273
146Exotropia (HP:0000577)1.83746894
147Acute lymphatic leukemia (HP:0006721)1.82814489
148Retinal atrophy (HP:0001105)1.82551217
149Microvesicular hepatic steatosis (HP:0001414)1.81575779
150Abnormal number of erythroid precursors (HP:0012131)1.81039958
151Annular pancreas (HP:0001734)1.80857263
152Hypothermia (HP:0002045)1.79472001
153Abnormal platelet volume (HP:0011876)1.79466315
154Clonus (HP:0002169)1.78321214
155Decreased circulating renin level (HP:0003351)1.77760294
156Increased CSF protein (HP:0002922)1.77602335
157Hypoventilation (HP:0002791)1.77581029
158Dyschromatopsia (HP:0007641)1.77336643
159Abnormality of cells of the erythroid lineage (HP:0012130)1.76801478
160Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76329091
161Generalized hypopigmentation of hair (HP:0011358)1.74525371
162Small hand (HP:0200055)1.74432677
163Hypomagnesemia (HP:0002917)1.74263138
164Resting tremor (HP:0002322)1.72609431
165Postaxial hand polydactyly (HP:0001162)1.72229140
166Central scotoma (HP:0000603)1.71846739
167Partial duplication of thumb phalanx (HP:0009944)1.71760015
16811 pairs of ribs (HP:0000878)1.70161868
169Short foot (HP:0001773)1.70142153
170Abnormality of macular pigmentation (HP:0008002)1.70140021
171Postnatal microcephaly (HP:0005484)1.68860252
172Bifid scrotum (HP:0000048)1.68332501
173Partial duplication of the phalanx of hand (HP:0009999)1.67722194
174Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.67254451
175Poor coordination (HP:0002370)1.66832803
176Acute necrotizing encephalopathy (HP:0006965)1.66745176
177Buphthalmos (HP:0000557)1.66030905
178Psychosis (HP:0000709)1.64739363
179Epistaxis (HP:0000421)1.63426130
180Macrocytic anemia (HP:0001972)1.62593964
181Complete atrioventricular canal defect (HP:0001674)1.62246063
182Pallor (HP:0000980)1.61966725
183Glucose intolerance (HP:0000833)1.61800150
184Postural tremor (HP:0002174)1.59969940
185Aortic dissection (HP:0002647)1.58344067
186Rectal fistula (HP:0100590)1.57978833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.49243374
2PRKD24.47333127
3MST1R4.20228264
4RIPK14.07021927
5GRK13.60626080
6CDK83.39862702
7ADRBK23.18577651
8ACVR1B3.16907991
9MUSK2.75330341
10TGFBR12.69422411
11BMX2.63844028
12WNK32.60577491
13TNK22.45534659
14HIPK22.45363110
15NME22.32816745
16CASK2.32367898
17BMPR1B2.26785752
18DYRK32.21516951
19NUAK12.18861724
20ABL22.12852622
21CSNK1G32.00477323
22MAP4K21.98801040
23ZAK1.93318168
24PINK11.85018228
25STK38L1.74492289
26INSRR1.73644235
27MAPK131.72935460
28MAPK71.71428309
29WNK41.66353478
30SCYL21.65936278
31TNIK1.63963147
32IRAK31.62312475
33PNCK1.60431351
34MET1.58686436
35SIK11.58628058
36TLK11.56975705
37TRIM281.54019386
38CSNK1G21.53250390
39CSNK1A1L1.47005558
40TAOK31.43075051
41PTK2B1.42720409
42NTRK31.42594280
43LRRK21.39815273
44CSNK1G11.39721345
45RPS6KA41.39314573
46STK31.39188478
47MAP3K41.39176136
48MAP3K21.39173565
49PIK3CG1.38839585
50IRAK41.34767498
51PAK31.32039771
52FES1.30707843
53MARK11.25095257
54CAMKK21.19292630
55PDPK11.15784967
56MKNK21.07846779
57DYRK21.03376201
58PLK21.00430839
59MAP3K120.99687156
60BRSK20.98911652
61PIK3CA0.97560360
62BCKDK0.91795565
63IRAK20.90842652
64UHMK10.89139503
65PRKD10.88617855
66HCK0.86077596
67SGK20.85650522
68CDK120.83587145
69MAPKAPK30.82166515
70BTK0.80213096
71BCR0.79460054
72LATS10.78472927
73NTRK10.78375734
74TXK0.77975842
75MAPK150.76289664
76SGK30.69045433
77CAMK2A0.69018962
78DDR20.68539207
79FER0.67257518
80MAP2K70.66147766
81PKN10.66143380
82SGK2230.64360220
83SGK4940.64360220
84CDK50.64335578
85CDK90.64333533
86MAP2K10.63897797
87SIK30.63813991
88GRK50.63597656
89CAMK10.62618033
90OXSR10.62472501
91IRAK10.62024425
92LIMK10.59618576
93TGFBR20.57397235
94AKT30.54768225
95CCNB10.52818661
96TTN0.52016281
97SIK20.51247365
98STK390.50552103
99ROCK20.50089156
100NLK0.49934607
101EPHB20.49914334
102MAP3K80.49227336
103CAMK2B0.48833547
104DAPK20.48727896
105STK240.48639834
106VRK10.48364562
107MYLK0.48185597
108GSK3A0.47397618
109PRKACA0.47187436
110CAMK40.44190863
111FGFR20.43964949
112WNK10.42469205
113PRKCE0.42289171
114PLK40.42217304
115CDK190.42049783
116OBSCN0.41824652
117SGK10.41410888
118IKBKB0.41253139
119PRKG10.40209048
120LMTK20.39494630
121MAPKAPK20.39005075
122SYK0.38570486
123ERBB20.38450302
124PLK30.38103899
125CAMK1G0.37061566
126MARK30.36070473
127PRKCA0.35860487
128MKNK10.35468352
129PRKAA20.33437634
130PKN20.33355806
131CSNK1D0.33198402
132EPHA30.32501067
133ROCK10.32075429
134MAPKAPK50.31303013
135ERBB30.30504694
136PHKG10.29494768
137PHKG20.29494768
138CAMK2D0.29073258
139MST40.28735100
140PRKCQ0.28254134
141PRKAA10.27492147
142PRKACG0.27372263
143ALK0.27142309
144MAPK110.27025827
145IGF1R0.26924351
146PRKCZ0.26686676
147CDK70.26026423
148CDK140.24607923
149KIT0.24489237
150TEC0.23864511
151CSNK1A10.23594936
152KSR20.22709819
153FRK0.22176436
154PRKCG0.21955701
155STK100.21531311
156EPHB10.19513267
157ADRBK10.19431679
158DAPK30.19277569
159ILK0.18353764
160PRKCH0.18062473
161FLT30.15186270
162FYN0.14918966
163PRKG20.14792608
164MAPK40.14683103

Predicted pathways (KEGG)

RankGene SetZ-score
1Folate biosynthesis_Homo sapiens_hsa007903.41404101
2Phototransduction_Homo sapiens_hsa047443.05505093
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.67293350
4Taste transduction_Homo sapiens_hsa047422.58140033
5Linoleic acid metabolism_Homo sapiens_hsa005912.57096885
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56247359
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.51985915
8Ribosome_Homo sapiens_hsa030102.31404970
9Vitamin B6 metabolism_Homo sapiens_hsa007502.27952748
10Basal cell carcinoma_Homo sapiens_hsa052172.26775139
11Protein digestion and absorption_Homo sapiens_hsa049742.15820924
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.12408335
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.10815139
14ECM-receptor interaction_Homo sapiens_hsa045122.10598153
15ABC transporters_Homo sapiens_hsa020102.06507995
16Platelet activation_Homo sapiens_hsa046111.99141991
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89552977
18Endometrial cancer_Homo sapiens_hsa052131.87096540
19Renin secretion_Homo sapiens_hsa049241.82862745
20Histidine metabolism_Homo sapiens_hsa003401.81977472
21Circadian entrainment_Homo sapiens_hsa047131.81860595
22Tryptophan metabolism_Homo sapiens_hsa003801.81646969
23Complement and coagulation cascades_Homo sapiens_hsa046101.81129585
24Ether lipid metabolism_Homo sapiens_hsa005651.79581171
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73537865
26Olfactory transduction_Homo sapiens_hsa047401.72704503
27Wnt signaling pathway_Homo sapiens_hsa043101.60653901
28Gap junction_Homo sapiens_hsa045401.59594660
29Chemical carcinogenesis_Homo sapiens_hsa052041.53737416
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.53043963
31Nitrogen metabolism_Homo sapiens_hsa009101.51831536
32Selenocompound metabolism_Homo sapiens_hsa004501.51652458
33Colorectal cancer_Homo sapiens_hsa052101.51555289
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46471022
35Salivary secretion_Homo sapiens_hsa049701.45891556
36Long-term depression_Homo sapiens_hsa047301.44200514
37One carbon pool by folate_Homo sapiens_hsa006701.43457009
38Arachidonic acid metabolism_Homo sapiens_hsa005901.42808545
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40810010
40Oxidative phosphorylation_Homo sapiens_hsa001901.39423658
41Phenylalanine metabolism_Homo sapiens_hsa003601.37991809
42Homologous recombination_Homo sapiens_hsa034401.32744148
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30338547
44Axon guidance_Homo sapiens_hsa043601.28173291
45Retinol metabolism_Homo sapiens_hsa008301.27236557
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.23792727
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.22682498
48Thyroid cancer_Homo sapiens_hsa052161.21226583
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19791696
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18237846
51Oxytocin signaling pathway_Homo sapiens_hsa049211.15303162
52Basal transcription factors_Homo sapiens_hsa030221.14317608
53Glycerolipid metabolism_Homo sapiens_hsa005611.13954724
54Cholinergic synapse_Homo sapiens_hsa047251.13817737
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13785180
56Hippo signaling pathway_Homo sapiens_hsa043901.11833526
57VEGF signaling pathway_Homo sapiens_hsa043701.11657377
58Parkinsons disease_Homo sapiens_hsa050121.10510924
59Caffeine metabolism_Homo sapiens_hsa002321.08686989
60Serotonergic synapse_Homo sapiens_hsa047261.07329642
61Fanconi anemia pathway_Homo sapiens_hsa034601.06785997
62Gastric acid secretion_Homo sapiens_hsa049711.05969825
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05763185
64Focal adhesion_Homo sapiens_hsa045101.04888632
65Protein export_Homo sapiens_hsa030601.02301926
66Ovarian steroidogenesis_Homo sapiens_hsa049131.01297955
67Calcium signaling pathway_Homo sapiens_hsa040201.00974483
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99811506
69Circadian rhythm_Homo sapiens_hsa047100.98203582
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98174723
71Sulfur metabolism_Homo sapiens_hsa009200.97744225
72Propanoate metabolism_Homo sapiens_hsa006400.95695337
73Collecting duct acid secretion_Homo sapiens_hsa049660.91524043
74Glioma_Homo sapiens_hsa052140.91504133
75Regulation of autophagy_Homo sapiens_hsa041400.90394965
76GABAergic synapse_Homo sapiens_hsa047270.89608083
77Glucagon signaling pathway_Homo sapiens_hsa049220.88695642
78Peroxisome_Homo sapiens_hsa041460.87730558
79Glutamatergic synapse_Homo sapiens_hsa047240.86541853
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85929659
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.85836768
82RNA polymerase_Homo sapiens_hsa030200.85591014
83Cardiac muscle contraction_Homo sapiens_hsa042600.85290151
84Amphetamine addiction_Homo sapiens_hsa050310.84445077
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83896215
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83002939
87Cocaine addiction_Homo sapiens_hsa050300.82774477
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82160904
89Dilated cardiomyopathy_Homo sapiens_hsa054140.81802762
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.80606374
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80326192
92Insulin secretion_Homo sapiens_hsa049110.80097568
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79589102
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78801590
95Steroid biosynthesis_Homo sapiens_hsa001000.77147672
96Morphine addiction_Homo sapiens_hsa050320.77014834
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75245600
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.75083824
99Huntingtons disease_Homo sapiens_hsa050160.74943250
100beta-Alanine metabolism_Homo sapiens_hsa004100.73399145
101Arginine biosynthesis_Homo sapiens_hsa002200.73116336
102Nicotine addiction_Homo sapiens_hsa050330.72872031
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72519160
104HIF-1 signaling pathway_Homo sapiens_hsa040660.66990427
105Bile secretion_Homo sapiens_hsa049760.66818861
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66184049
107Butanoate metabolism_Homo sapiens_hsa006500.65912296
108Tight junction_Homo sapiens_hsa045300.65811234
109Fat digestion and absorption_Homo sapiens_hsa049750.65789850
110Pancreatic secretion_Homo sapiens_hsa049720.65556152
111mRNA surveillance pathway_Homo sapiens_hsa030150.65193893
112Estrogen signaling pathway_Homo sapiens_hsa049150.64978226
113Alzheimers disease_Homo sapiens_hsa050100.64789412
114ErbB signaling pathway_Homo sapiens_hsa040120.64745723
115MicroRNAs in cancer_Homo sapiens_hsa052060.63005835
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62882389
117Inositol phosphate metabolism_Homo sapiens_hsa005620.62487573
118Synaptic vesicle cycle_Homo sapiens_hsa047210.62105381
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59740889
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.59698989
121Prion diseases_Homo sapiens_hsa050200.59187100
122Melanogenesis_Homo sapiens_hsa049160.58672516
123Proteoglycans in cancer_Homo sapiens_hsa052050.58605689
124Sphingolipid metabolism_Homo sapiens_hsa006000.58490540
125Long-term potentiation_Homo sapiens_hsa047200.58096886
126Dorso-ventral axis formation_Homo sapiens_hsa043200.57798554
127Purine metabolism_Homo sapiens_hsa002300.57695094
128TGF-beta signaling pathway_Homo sapiens_hsa043500.57093297
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.57061309
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56498427
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55660039
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55322076
133Fatty acid metabolism_Homo sapiens_hsa012120.55137489
134Hedgehog signaling pathway_Homo sapiens_hsa043400.53822664
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.53087389
136Dopaminergic synapse_Homo sapiens_hsa047280.52995893
137Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52779792
138Rap1 signaling pathway_Homo sapiens_hsa040150.52645705
139Metabolic pathways_Homo sapiens_hsa011000.52403428
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51910237
141Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49348059
142Non-small cell lung cancer_Homo sapiens_hsa052230.49194832
143cAMP signaling pathway_Homo sapiens_hsa040240.49061983
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48416387
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48191946
146Fatty acid degradation_Homo sapiens_hsa000710.47719411
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46717279
148cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46351012
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45568622
150Tyrosine metabolism_Homo sapiens_hsa003500.45112121
151Pathways in cancer_Homo sapiens_hsa052000.44518399
152Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44517773
153PPAR signaling pathway_Homo sapiens_hsa033200.44009526
154Intestinal immune network for IgA production_Homo sapiens_hsa046720.43161335
155Ras signaling pathway_Homo sapiens_hsa040140.43080798
156RNA degradation_Homo sapiens_hsa030180.42624689
157Thyroid hormone synthesis_Homo sapiens_hsa049180.42372722
158Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42161652
159Mineral absorption_Homo sapiens_hsa049780.40189831

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »