SBF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a pseudophosphatase and member of the myotubularin-related protein family. This gene maps within the CMT4B2 candidate region of chromosome 11p15 and mutations in this gene have been associated with Charcot-Marie-Tooth Disease, type 4B2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.40401574
2regulation of hippo signaling (GO:0035330)3.73708502
3L-fucose catabolic process (GO:0042355)3.41037098
4fucose catabolic process (GO:0019317)3.41037098
5L-fucose metabolic process (GO:0042354)3.41037098
6neuron projection extension involved in neuron projection guidance (GO:1902284)3.23727352
7axon extension involved in axon guidance (GO:0048846)3.23727352
8nucleobase catabolic process (GO:0046113)3.09168368
9neural tube formation (GO:0001841)2.99239036
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95611495
11gamma-aminobutyric acid transport (GO:0015812)2.95238361
12nephron tubule morphogenesis (GO:0072078)2.93939909
13nephron epithelium morphogenesis (GO:0072088)2.93939909
14regulation of posttranscriptional gene silencing (GO:0060147)2.91827886
15regulation of gene silencing by miRNA (GO:0060964)2.91827886
16regulation of gene silencing by RNA (GO:0060966)2.91827886
17kidney morphogenesis (GO:0060993)2.90081258
18postsynaptic membrane organization (GO:0001941)2.89905505
19presynaptic membrane assembly (GO:0097105)2.86322592
20renal tubule morphogenesis (GO:0061333)2.84558461
21indole-containing compound catabolic process (GO:0042436)2.82832165
22indolalkylamine catabolic process (GO:0046218)2.82832165
23tryptophan catabolic process (GO:0006569)2.82832165
24regulation of axon guidance (GO:1902667)2.81830938
25regulation of axon extension involved in axon guidance (GO:0048841)2.81726604
26negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79415054
27response to pheromone (GO:0019236)2.78325006
28nonmotile primary cilium assembly (GO:0035058)2.74249378
29ganglion development (GO:0061548)2.74069328
30dermatan sulfate biosynthetic process (GO:0030208)2.71703821
31pericardium development (GO:0060039)2.71620604
32indolalkylamine metabolic process (GO:0006586)2.68519559
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.66456061
34cAMP catabolic process (GO:0006198)2.66145302
35establishment of nucleus localization (GO:0040023)2.65440394
36dendrite morphogenesis (GO:0048813)2.64537057
37kynurenine metabolic process (GO:0070189)2.61460218
38neuronal stem cell maintenance (GO:0097150)2.60997930
39limb development (GO:0060173)2.60972822
40appendage development (GO:0048736)2.60972822
41neuronal action potential (GO:0019228)2.56999942
42retina layer formation (GO:0010842)2.56515506
43limb bud formation (GO:0060174)2.56111560
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.53533313
45fibroblast migration (GO:0010761)2.53161488
46nucleus localization (GO:0051647)2.51803447
47tryptophan metabolic process (GO:0006568)2.50526320
48positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.49362709
49cyclic nucleotide catabolic process (GO:0009214)2.49149356
50presynaptic membrane organization (GO:0097090)2.49006116
51negative chemotaxis (GO:0050919)2.48863083
52semaphorin-plexin signaling pathway (GO:0071526)2.48785349
53head development (GO:0060322)2.48326618
54positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.47787250
55retinal ganglion cell axon guidance (GO:0031290)2.47654509
56insulin-like growth factor receptor signaling pathway (GO:0048009)2.47640831
57regulation of pigment cell differentiation (GO:0050932)2.47338473
58regulation of non-canonical Wnt signaling pathway (GO:2000050)2.45988693
59behavioral response to ethanol (GO:0048149)2.45786756
60dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.45735245
61cardiac myofibril assembly (GO:0055003)2.43860818
62regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.40158204
63primary amino compound metabolic process (GO:1901160)2.38519458
64negative regulation of axon guidance (GO:1902668)2.38194823
65negative regulation of systemic arterial blood pressure (GO:0003085)2.37857900
66axonal fasciculation (GO:0007413)2.36628105
67serotonin metabolic process (GO:0042428)2.36424910
68layer formation in cerebral cortex (GO:0021819)2.35859206
69sulfation (GO:0051923)2.34659441
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.33066054
71urinary tract smooth muscle contraction (GO:0014848)2.32353348
72artery development (GO:0060840)2.31925862
73spinal cord development (GO:0021510)2.30741996
74regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.30330614
75cytoplasmic mRNA processing body assembly (GO:0033962)2.30114224
76positive regulation of fatty acid oxidation (GO:0046321)2.29990124
77protein K11-linked deubiquitination (GO:0035871)2.29091500
78negative regulation of synaptic transmission, GABAergic (GO:0032229)2.28817195
79indole-containing compound metabolic process (GO:0042430)2.28428895
80negative regulation of axon extension involved in axon guidance (GO:0048843)2.28324018
81axon extension (GO:0048675)2.28260628
82spinal cord motor neuron differentiation (GO:0021522)2.27823699
83atrial cardiac muscle cell action potential (GO:0086014)2.27566487
84regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.27436490
85cerebral cortex radially oriented cell migration (GO:0021799)2.27304820
86dermatan sulfate metabolic process (GO:0030205)2.26985328
87hindbrain development (GO:0030902)2.26753267
88neuron maturation (GO:0042551)2.26195880
89glomerulus development (GO:0032835)2.25984844
90inner ear receptor cell development (GO:0060119)2.25572128
91interkinetic nuclear migration (GO:0022027)2.24753604
92detection of light stimulus involved in visual perception (GO:0050908)2.24558889
93detection of light stimulus involved in sensory perception (GO:0050962)2.24558889
94glutamate receptor signaling pathway (GO:0007215)2.24464722
95membrane depolarization during action potential (GO:0086010)2.23308518
96central nervous system projection neuron axonogenesis (GO:0021952)2.23086689
97heart morphogenesis (GO:0003007)2.21965938
98embryonic retina morphogenesis in camera-type eye (GO:0060059)2.21631786
99negative regulation of Rho protein signal transduction (GO:0035024)2.21556596
100calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.21279041
101startle response (GO:0001964)2.21083339
102retina vasculature morphogenesis in camera-type eye (GO:0061299)2.20591940
103photoreceptor cell maintenance (GO:0045494)2.20253894
104smooth muscle contraction (GO:0006939)2.19956297
105inner ear receptor stereocilium organization (GO:0060122)2.19727191
106dendritic spine morphogenesis (GO:0060997)2.18858799
107cilium morphogenesis (GO:0060271)2.18611641
108somite development (GO:0061053)2.17754892
109locomotory exploration behavior (GO:0035641)2.17334809
110regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.16874664
111cilium or flagellum-dependent cell motility (GO:0001539)2.15544110
112regulation of protein polyubiquitination (GO:1902914)2.14477580
113cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.13128957
114regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.13091693
115neurotransmitter-gated ion channel clustering (GO:0072578)2.12265344
116lymphangiogenesis (GO:0001946)2.12015064
117vascular endothelial growth factor signaling pathway (GO:0038084)2.10824442
118glomerular basement membrane development (GO:0032836)2.09914311
119negative regulation of vascular permeability (GO:0043116)2.09637892
120positive regulation of hormone biosynthetic process (GO:0046886)2.09507335
121regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.08931621
122ionotropic glutamate receptor signaling pathway (GO:0035235)2.08776653
123vocalization behavior (GO:0071625)2.08665001
124regulation of glutamate receptor signaling pathway (GO:1900449)2.08465162
125regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.08096846
126cell communication by electrical coupling (GO:0010644)2.08022677
127regulation of neuron migration (GO:2001222)2.06695751
128negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.06248361
129negative regulation of translation, ncRNA-mediated (GO:0040033)2.06248361
130regulation of translation, ncRNA-mediated (GO:0045974)2.06248361
131anatomical structure arrangement (GO:0048532)2.05918174
132positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.05311766
133neuron recognition (GO:0008038)2.04857649
134hippo signaling (GO:0035329)2.04614152
135peripheral nervous system axon ensheathment (GO:0032292)2.04415999
136myelination in peripheral nervous system (GO:0022011)2.04415999
137positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.03821897
138growth hormone receptor signaling pathway (GO:0060396)2.02816404
139paraxial mesoderm development (GO:0048339)2.01268941
140glial cell proliferation (GO:0014009)2.00454178
141coronary vasculature morphogenesis (GO:0060977)2.00278893
142histone H3-K4 trimethylation (GO:0080182)1.99764714
143epithelial cell differentiation involved in kidney development (GO:0035850)1.99349171
144neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)1.98916180
145histone H3-K36 demethylation (GO:0070544)1.98355786
146cell adhesion mediated by integrin (GO:0033627)1.96667771
147positive regulation of cellular amide metabolic process (GO:0034250)1.96667721
148innervation (GO:0060384)1.96540956
149gastrulation with mouth forming second (GO:0001702)1.96476911
150myoblast fusion (GO:0007520)1.96093832
151camera-type eye morphogenesis (GO:0048593)1.95703615
152cell migration in hindbrain (GO:0021535)1.95599088
153morphogenesis of an epithelial sheet (GO:0002011)1.95000524
154metanephric tubule development (GO:0072170)1.93725435
155metanephric nephron tubule development (GO:0072234)1.93725435
156macroautophagy (GO:0016236)1.92965928
157cranial nerve structural organization (GO:0021604)1.91984003
158metanephric mesenchyme development (GO:0072075)1.91889108
159synaptic vesicle docking involved in exocytosis (GO:0016081)1.91427280
160planar cell polarity pathway involved in neural tube closure (GO:0090179)1.90972340
161myofibril assembly (GO:0030239)1.90217175
162neuron projection extension (GO:1990138)1.89869071
163stress granule assembly (GO:0034063)1.89792195
164regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)1.89776957
165metanephric epithelium development (GO:0072207)1.89625371
166regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.89406962
167cell differentiation involved in kidney development (GO:0061005)1.88924191
168regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.88598003
169metanephric nephron epithelium development (GO:0072243)1.88544453
170gonadal mesoderm development (GO:0007506)1.88360203
171histone H3-K9 demethylation (GO:0033169)1.88343882
172central nervous system neuron axonogenesis (GO:0021955)1.88178801
173pyrimidine nucleobase catabolic process (GO:0006208)1.85602612
174regulation of inhibitory postsynaptic membrane potential (GO:0060080)1.85192107
175cell communication involved in cardiac conduction (GO:0086065)1.84886556
176cerebral cortex cell migration (GO:0021795)1.84741537
177polyketide metabolic process (GO:0030638)1.84596584
178doxorubicin metabolic process (GO:0044598)1.84596584
179daunorubicin metabolic process (GO:0044597)1.84596584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.79426760
2* GBX2_23144817_ChIP-Seq_PC3_Human2.98848586
3ZNF274_21170338_ChIP-Seq_K562_Hela2.62902807
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22731033
5VDR_22108803_ChIP-Seq_LS180_Human2.11976724
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97654370
7DROSHA_22980978_ChIP-Seq_HELA_Human1.95067193
8TAF15_26573619_Chip-Seq_HEK293_Human1.92771311
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89655288
10FUS_26573619_Chip-Seq_HEK293_Human1.85416773
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83772357
12EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79637613
13RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79637613
14* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78987800
15CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75293935
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.73891625
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73875174
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73449372
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72766689
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.71425662
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68031413
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65304105
23* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65136643
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.64224803
25* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61648489
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.58606407
27EWS_26573619_Chip-Seq_HEK293_Human1.58324745
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.56664502
29ER_23166858_ChIP-Seq_MCF-7_Human1.54346949
30* EP300_21415370_ChIP-Seq_HL-1_Mouse1.53252193
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.52361594
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52033687
33AHR_22903824_ChIP-Seq_MCF-7_Human1.51835376
34SMAD4_21799915_ChIP-Seq_A2780_Human1.51559853
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51071190
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50182859
37* PIAS1_25552417_ChIP-Seq_VCAP_Human1.47865279
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47847053
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47220937
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.44663631
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.42161816
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39822192
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39174540
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.39046086
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38536173
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38062897
47TP53_16413492_ChIP-PET_HCT116_Human1.37440919
48STAT3_23295773_ChIP-Seq_U87_Human1.37269665
49AR_21572438_ChIP-Seq_LNCaP_Human1.37126568
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35808178
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35695688
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35686794
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.33448917
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31810015
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30872236
56CBP_20019798_ChIP-Seq_JUKART_Human1.30872236
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28073840
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27690721
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27690721
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27274460
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27274460
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26656971
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26524392
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26435326
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25797906
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25049196
67* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23323215
68SMAD3_21741376_ChIP-Seq_HESCs_Human1.22144132
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21761917
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20486627
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20482893
72P300_19829295_ChIP-Seq_ESCs_Human1.20059480
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19198992
74* TCF4_22108803_ChIP-Seq_LS180_Human1.19183819
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19009856
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.17634433
77* TCF4_23295773_ChIP-Seq_U87_Human1.17312113
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.17184318
79TP53_18474530_ChIP-ChIP_U2OS_Human1.16519148
80BCAT_22108803_ChIP-Seq_LS180_Human1.16272834
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14788033
82* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14698389
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14628207
84ISL1_27105846_Chip-Seq_CPCs_Mouse1.14163836
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14152839
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14051688
87* PRDM14_20953172_ChIP-Seq_ESCs_Human1.12828363
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.12486967
89RXR_22108803_ChIP-Seq_LS180_Human1.11484481
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11434196
91KDM2B_26808549_Chip-Seq_REH_Human1.11200648
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11189396
93RNF2_27304074_Chip-Seq_NSC_Mouse1.11035218
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10691196
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10578110
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09803826
97* AR_19668381_ChIP-Seq_PC3_Human1.09730755
98* SMAD4_21741376_ChIP-Seq_EPCs_Human1.08059241
99* SMAD4_21741376_ChIP-Seq_HESCs_Human1.07686028
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06422964
101* AR_25329375_ChIP-Seq_VCAP_Human1.05556379
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05155844
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.04746578
104CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04403435
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03163264
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02949484
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02932111
108CJUN_26792858_Chip-Seq_BT549_Human1.02763547
109IGF1R_20145208_ChIP-Seq_DFB_Human1.01968867
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01586967
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00488269
112CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99956588
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.99731331
114* RUNX2_22187159_ChIP-Seq_PCA_Human0.99009349
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98853392
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97821341
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97048020
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97008964
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.96947394
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95888628
121WT1_19549856_ChIP-ChIP_CCG9911_Human0.95368586
122TRIM28_21343339_ChIP-Seq_HEK293_Human0.95349384
123VDR_24787735_ChIP-Seq_THP-1_Human0.94751162
124TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94294198
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94204768
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94058153
127* REST_21632747_ChIP-Seq_MESCs_Mouse0.93998239
128TBL1_22424771_ChIP-Seq_293T_Human0.93348422
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.92335348
130E2F1_18555785_Chip-Seq_ESCs_Mouse0.92161346
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91826714
132WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90722637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.42413635
2MP0008438_abnormal_cutaneous_collagen2.86229177
3MP0004272_abnormal_basement_membrane2.52576609
4MP0000566_synostosis2.49065779
5MP0005248_abnormal_Harderian_gland2.48869021
6MP0004859_abnormal_synaptic_plasticity2.43403207
7MP0005171_absent_coat_pigmentation2.39810491
8MP0005503_abnormal_tendon_morphology2.36905372
9MP0005623_abnormal_meninges_morphology2.30110695
10MP0003136_yellow_coat_color2.18699702
11MP0005257_abnormal_intraocular_pressure2.08554134
12MP0005551_abnormal_eye_electrophysiolog2.01690810
13MP0003195_calcinosis1.99497718
14MP0000778_abnormal_nervous_system1.98613086
15MP0008877_abnormal_DNA_methylation1.97941117
16MP0003045_fibrosis1.91486999
17MP0003385_abnormal_body_wall1.88394513
18MP0004858_abnormal_nervous_system1.87961749
19MP0006292_abnormal_olfactory_placode1.87577235
20MP0000427_abnormal_hair_cycle1.77016938
21MP0003283_abnormal_digestive_organ1.74858519
22MP0010368_abnormal_lymphatic_system1.74360462
23MP0002876_abnormal_thyroid_physiology1.64129333
24MP0003705_abnormal_hypodermis_morpholog1.62191825
25MP0005174_abnormal_tail_pigmentation1.60108055
26MP0003941_abnormal_skin_development1.53077634
27MP0009780_abnormal_chondrocyte_physiolo1.49150815
28MP0004043_abnormal_pH_regulation1.49007166
29MP0001968_abnormal_touch/_nociception1.42636396
30MP0004142_abnormal_muscle_tone1.40719891
31MP0005377_hearing/vestibular/ear_phenot1.40370069
32MP0003878_abnormal_ear_physiology1.40370069
33MP0009745_abnormal_behavioral_response1.38600721
34MP0001299_abnormal_eye_distance/1.37832930
35MP0000631_abnormal_neuroendocrine_gland1.37240334
36MP0003122_maternal_imprinting1.35528714
37MP0002735_abnormal_chemical_nociception1.34651810
38MP0005167_abnormal_blood-brain_barrier1.34517870
39MP0005253_abnormal_eye_physiology1.32496732
40MP0005275_abnormal_skin_tensile1.30560008
41MP0002108_abnormal_muscle_morphology1.29750871
42MP0002938_white_spotting1.28834624
43MP0004885_abnormal_endolymph1.27987359
44* MP0002272_abnormal_nervous_system1.27335205
45MP0002638_abnormal_pupillary_reflex1.25167362
46MP0002736_abnormal_nociception_after1.23870155
47MP0001485_abnormal_pinna_reflex1.23709981
48MP0001984_abnormal_olfaction1.23017789
49MP0003115_abnormal_respiratory_system1.22303789
50MP0003646_muscle_fatigue1.22284811
51MP0000955_abnormal_spinal_cord1.21937345
52MP0000733_abnormal_muscle_development1.21223105
53MP0002249_abnormal_larynx_morphology1.20704349
54MP0005670_abnormal_white_adipose1.20231450
55MP0003935_abnormal_craniofacial_develop1.20220912
56MP0004084_abnormal_cardiac_muscle1.20127299
57MP0000751_myopathy1.17240713
58MP0010386_abnormal_urinary_bladder1.17184874
59MP0006072_abnormal_retinal_apoptosis1.17100450
60MP0000767_abnormal_smooth_muscle1.17095550
61MP0004924_abnormal_behavior1.16852837
62MP0005386_behavior/neurological_phenoty1.16852837
63MP0001958_emphysema1.16777178
64MP0005076_abnormal_cell_differentiation1.16596108
65MP0006138_congestive_heart_failure1.16401310
66MP0003121_genomic_imprinting1.16268357
67MP0006276_abnormal_autonomic_nervous1.15983719
68MP0005645_abnormal_hypothalamus_physiol1.15691900
69MP0002160_abnormal_reproductive_system1.15634885
70MP0001879_abnormal_lymphatic_vessel1.15421871
71MP0005195_abnormal_posterior_eye1.14793681
72MP0003091_abnormal_cell_migration1.14236949
73MP0001486_abnormal_startle_reflex1.13248915
74MP0001501_abnormal_sleep_pattern1.12168826
75MP0004133_heterotaxia1.11855276
76MP0005187_abnormal_penis_morphology1.11399501
77MP0003632_abnormal_nervous_system1.09607151
78MP0002734_abnormal_mechanical_nocicepti1.09575066
79MP0005595_abnormal_vascular_smooth1.07980446
80MP0003950_abnormal_plasma_membrane1.07813779
81MP0004215_abnormal_myocardial_fiber1.07258690
82MP0003787_abnormal_imprinting1.07072277
83MP0005423_abnormal_somatic_nervous1.06805489
84MP0003890_abnormal_embryonic-extraembry1.06670363
85MP0002168_other_aberrant_phenotype1.05989589
86* MP0002067_abnormal_sensory_capabilities1.05842656
87MP0010678_abnormal_skin_adnexa1.05681523
88MP0000538_abnormal_urinary_bladder1.05620490
89MP0003635_abnormal_synaptic_transmissio1.05305386
90MP0002837_dystrophic_cardiac_calcinosis1.04926661
91MP0000534_abnormal_ureter_morphology1.04394435
92MP0000383_abnormal_hair_follicle1.04281228
93MP0003937_abnormal_limbs/digits/tail_de1.03958752
94MP0003119_abnormal_digestive_system1.03898065
95MP0002254_reproductive_system_inflammat1.03473005
96MP0001986_abnormal_taste_sensitivity1.03338235
97MP0000230_abnormal_systemic_arterial1.02674557
98MP0009384_cardiac_valve_regurgitation1.02624816
99MP0002064_seizures1.01738123
100MP0000516_abnormal_urinary_system1.01069752
101MP0005367_renal/urinary_system_phenotyp1.01069752
102MP0005646_abnormal_pituitary_gland1.01025150
103MP0002557_abnormal_social/conspecific_i1.00763715
104MP0004085_abnormal_heartbeat1.00761233
105MP0002896_abnormal_bone_mineralization1.00527370
106MP0002752_abnormal_somatic_nervous1.00238300
107MP0003690_abnormal_glial_cell0.99820989
108MP0001970_abnormal_pain_threshold0.98903554
109MP0002116_abnormal_craniofacial_bone0.98633209
110MP0001286_abnormal_eye_development0.98601079
111MP0002697_abnormal_eye_size0.97733465
112MP0003755_abnormal_palate_morphology0.97038181
113MP0008775_abnormal_heart_ventricle0.95643671
114* MP0002882_abnormal_neuron_morphology0.95622901
115MP0002063_abnormal_learning/memory/cond0.95562622
116MP0003252_abnormal_bile_duct0.94779202
117MP0002102_abnormal_ear_morphology0.93723508
118MP0002733_abnormal_thermal_nociception0.93239846
119MP0009046_muscle_twitch0.92989119
120MP0002928_abnormal_bile_duct0.92808718
121MP0002184_abnormal_innervation0.92470736
122MP0000026_abnormal_inner_ear0.92455498
123MP0003942_abnormal_urinary_system0.91378623
124MP0005666_abnormal_adipose_tissue0.89706699
125MP0004145_abnormal_muscle_electrophysio0.88758202
126MP0002234_abnormal_pharynx_morphology0.88538732
127MP0000432_abnormal_head_morphology0.87686309
128MP0004270_analgesia0.87592950
129MP0004742_abnormal_vestibular_system0.87419941
130MP0004130_abnormal_muscle_cell0.87383314
131MP0002233_abnormal_nose_morphology0.86715356
132MP0000537_abnormal_urethra_morphology0.86502362
133MP0001324_abnormal_eye_pigmentation0.86497977
134MP0003828_pulmonary_edema0.85615360
135MP0000647_abnormal_sebaceous_gland0.83882070
136MP0005391_vision/eye_phenotype0.83868385
137MP0009250_abnormal_appendicular_skeleto0.83684981
138MP0002925_abnormal_cardiovascular_devel0.83213142
139MP0002972_abnormal_cardiac_muscle0.81042764
140MP0003634_abnormal_glial_cell0.79802608
141MP0005197_abnormal_uvea_morphology0.78738749
142MP0003566_abnormal_cell_adhesion0.78632266
143MP0002572_abnormal_emotion/affect_behav0.78629887
144MP0010630_abnormal_cardiac_muscle0.78277658
145MP0005620_abnormal_muscle_contractility0.77933557
146MP0003861_abnormal_nervous_system0.77868129
147MP0001293_anophthalmia0.77237302
148MP0003279_aneurysm0.77227344
149MP0001177_atelectasis0.77218138
150MP0000049_abnormal_middle_ear0.77050182
151MP0004233_abnormal_muscle_weight0.75963268
152MP0002152_abnormal_brain_morphology0.75681300
153MP0002127_abnormal_cardiovascular_syste0.75508589
154MP0005508_abnormal_skeleton_morphology0.74907907
155MP0000428_abnormal_craniofacial_morphol0.74571176
156MP0002653_abnormal_ependyma_morphology0.74275157
157MP0004185_abnormal_adipocyte_glucose0.73882714

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.19408738
2Pancreatic cysts (HP:0001737)3.63996410
3Molar tooth sign on MRI (HP:0002419)3.48530481
4Abnormality of midbrain morphology (HP:0002418)3.48530481
5Pancreatic fibrosis (HP:0100732)3.39241555
6Protruding tongue (HP:0010808)3.25833791
7Type II lissencephaly (HP:0007260)3.18988934
8Nephronophthisis (HP:0000090)3.16524598
9True hermaphroditism (HP:0010459)3.08525009
10Abnormality of the renal medulla (HP:0100957)2.94155764
11Shallow orbits (HP:0000586)2.92024780
12Congenital stationary night blindness (HP:0007642)2.88449981
13Midline defect of the nose (HP:0004122)2.78860743
14Increased corneal curvature (HP:0100692)2.71899065
15Keratoconus (HP:0000563)2.71899065
16Abnormality of the renal cortex (HP:0011035)2.71206105
17Fair hair (HP:0002286)2.70469363
18Tubular atrophy (HP:0000092)2.64117066
19Inability to walk (HP:0002540)2.62466978
20Gaze-evoked nystagmus (HP:0000640)2.61780881
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59844550
22Short 4th metacarpal (HP:0010044)2.59844550
23Broad-based gait (HP:0002136)2.59158579
24Cerebellar dysplasia (HP:0007033)2.49125449
25Abnormality of alanine metabolism (HP:0010916)2.49090655
26Hyperalaninemia (HP:0003348)2.49090655
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49090655
28Absent/shortened dynein arms (HP:0200106)2.48733488
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.48733488
30Lissencephaly (HP:0001339)2.46139482
31Lymphangioma (HP:0100764)2.45334348
32Aplasia/Hypoplasia of the tibia (HP:0005772)2.44140647
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.38756872
34Cystic liver disease (HP:0006706)2.36961235
35Subacute progressive viral hepatitis (HP:0006572)2.36590497
36Febrile seizures (HP:0002373)2.31816435
37Papillary thyroid carcinoma (HP:0002895)2.31067285
38Hepatoblastoma (HP:0002884)2.30700955
39Partial agenesis of the corpus callosum (HP:0001338)2.27097311
40Preaxial foot polydactyly (HP:0001841)2.26720758
41Broad metatarsal (HP:0001783)2.23854125
42Medial flaring of the eyebrow (HP:0010747)2.22316311
43Optic nerve hypoplasia (HP:0000609)2.21599848
44Bulbous nose (HP:0000414)2.21011759
45Clumsiness (HP:0002312)2.19251296
46Progressive inability to walk (HP:0002505)2.18513097
47Abnormality of the nasal septum (HP:0000419)2.11646640
48Elfin facies (HP:0004428)2.10700774
49Generalized hypopigmentation of hair (HP:0011358)2.09092369
50Abnormality of the 4th metacarpal (HP:0010012)2.08897700
51Hematochezia (HP:0002573)2.06896947
52Cerebral aneurysm (HP:0004944)2.04208043
53Genetic anticipation (HP:0003743)2.02788797
54Patellar aplasia (HP:0006443)2.02751155
55Absent eyebrow (HP:0002223)2.02220474
56Attenuation of retinal blood vessels (HP:0007843)2.01938942
57Abnormality of the labia majora (HP:0012881)2.01397009
58Hemiparesis (HP:0001269)2.00565287
59Decreased circulating renin level (HP:0003351)2.00235099
60Narrow palate (HP:0000189)2.00209831
61Renovascular hypertension (HP:0100817)2.00044281
62Focal seizures (HP:0007359)2.00041038
63Genital tract atresia (HP:0001827)1.99127716
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98245227
65Macroorchidism (HP:0000053)1.98099109
66Abnormal drinking behavior (HP:0030082)1.97522750
67Polydipsia (HP:0001959)1.97522750
68Aplasia/Hypoplasia of the tongue (HP:0010295)1.97250138
69Bell-shaped thorax (HP:0001591)1.97175952
70Gait imbalance (HP:0002141)1.96453935
71Absent frontal sinuses (HP:0002688)1.95507318
72Atrial fibrillation (HP:0005110)1.95188533
73Blue irides (HP:0000635)1.93994257
74Drooling (HP:0002307)1.93884345
75Excessive salivation (HP:0003781)1.93884345
76Short foot (HP:0001773)1.90482808
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89383329
78Cutaneous finger syndactyly (HP:0010554)1.88832125
79Vaginal atresia (HP:0000148)1.87731809
80Hypoplastic ischia (HP:0003175)1.87606782
81Skull defect (HP:0001362)1.87032066
82Aplasia/Hypoplasia of the patella (HP:0006498)1.83173697
83Action tremor (HP:0002345)1.81337995
84Congenital hepatic fibrosis (HP:0002612)1.80822331
85Bronchomalacia (HP:0002780)1.80464179
86Abolished electroretinogram (ERG) (HP:0000550)1.78418174
87Primary atrial arrhythmia (HP:0001692)1.77896878
88Congenital primary aphakia (HP:0007707)1.77385833
89Bladder diverticulum (HP:0000015)1.76574909
90Birth length less than 3rd percentile (HP:0003561)1.75114949
91Broad ribs (HP:0000885)1.74542808
92Anophthalmia (HP:0000528)1.74435294
93Poor coordination (HP:0002370)1.73298733
94Anencephaly (HP:0002323)1.73298076
95Small hand (HP:0200055)1.73193003
96Hypoplasia of the iris (HP:0007676)1.72985618
97Cupped ear (HP:0000378)1.72644878
98Prominent supraorbital ridges (HP:0000336)1.72529895
99Inappropriate behavior (HP:0000719)1.71738694
100Cortical dysplasia (HP:0002539)1.70884629
101Retinal dysplasia (HP:0007973)1.70658352
102Chronic hepatic failure (HP:0100626)1.70627917
103Nephrogenic diabetes insipidus (HP:0009806)1.70455291
104Macroglossia (HP:0000158)1.68437467
105Aqueductal stenosis (HP:0002410)1.68191858
106Fibular hypoplasia (HP:0003038)1.67748543
107Aortic aneurysm (HP:0004942)1.67734841
108Abnormality of the ischium (HP:0003174)1.67308836
109Labial hypoplasia (HP:0000066)1.67283687
110Oligodactyly (hands) (HP:0001180)1.66472795
111Postaxial hand polydactyly (HP:0001162)1.66356553
112Renal cortical cysts (HP:0000803)1.65694438
113Anterior segment dysgenesis (HP:0007700)1.65639370
114Furrowed tongue (HP:0000221)1.65119083
115Exotropia (HP:0000577)1.64615593
116Postaxial foot polydactyly (HP:0001830)1.63945221
117Sclerocornea (HP:0000647)1.63710286
118Abnormality of the diencephalon (HP:0010662)1.63046297
119Short chin (HP:0000331)1.63007494
120Aneurysm (HP:0002617)1.61681863
121Uterine leiomyosarcoma (HP:0002891)1.61563970
122Leiomyosarcoma (HP:0100243)1.61563970
123Wide anterior fontanel (HP:0000260)1.61159720
124Atonic seizures (HP:0010819)1.60650513
125Congenital sensorineural hearing impairment (HP:0008527)1.60465766
126Prolonged QT interval (HP:0001657)1.60443784
127Arthropathy (HP:0003040)1.59869721
128Renal dysplasia (HP:0000110)1.59839251
129Intellectual disability, moderate (HP:0002342)1.59448860
130Aortic dissection (HP:0002647)1.59096795
131Chorioretinal atrophy (HP:0000533)1.58310357
132Syncope (HP:0001279)1.57979212
133Urethral obstruction (HP:0000796)1.57198544
134Advanced eruption of teeth (HP:0006288)1.56498839
135Heterotopia (HP:0002282)1.55816100
136Germ cell neoplasia (HP:0100728)1.55292696
137Lower limb amyotrophy (HP:0007210)1.54932537
138Follicular hyperkeratosis (HP:0007502)1.54616494
139Trigonocephaly (HP:0000243)1.54156134
140Turricephaly (HP:0000262)1.54052620
141Transitional cell carcinoma of the bladder (HP:0006740)1.53310402
142Arterial tortuosity (HP:0005116)1.52729286
143Supraventricular arrhythmia (HP:0005115)1.52218226
144Cutaneous syndactyly (HP:0012725)1.51688877
145Portal hypertension (HP:0001409)1.51420321
146Aplasia cutis congenita (HP:0001057)1.51125078
147Abnormal respiratory motile cilium physiology (HP:0012261)1.50339563
148Progressive cerebellar ataxia (HP:0002073)1.50335186
149Rectal prolapse (HP:0002035)1.49460028
150Supraventricular tachycardia (HP:0004755)1.49348025
151Obsessive-compulsive behavior (HP:0000722)1.47077785
152Termporal pattern (HP:0011008)1.46726957
153Insidious onset (HP:0003587)1.46726957
154Buphthalmos (HP:0000557)1.46370213
155Sudden death (HP:0001699)1.46012871
156Stage 5 chronic kidney disease (HP:0003774)1.45792834
157Coronal craniosynostosis (HP:0004440)1.45511743
158Absent speech (HP:0001344)1.45095358
159Supernumerary ribs (HP:0005815)1.44343186
160Thick nail (HP:0001805)1.44287514
161Pulmonary artery stenosis (HP:0004415)1.43852427
162Abnormality of the pubic bones (HP:0003172)1.43676489
163Mitral valve prolapse (HP:0001634)1.43648220
164Smooth philtrum (HP:0000319)1.43614885
165Disinhibition (HP:0000734)1.43045984
166Premature rupture of membranes (HP:0001788)1.42470445
167Nephritis (HP:0000123)1.42442036
168Vascular tortuosity (HP:0004948)1.42219611
169Pachygyria (HP:0001302)1.41208303
170Enlarged penis (HP:0000040)1.41089642
171Abnormality of the hepatic vasculature (HP:0006707)1.41046582
172Morphological abnormality of the middle ear (HP:0008609)1.40988316
173Hypoplastic labia majora (HP:0000059)1.40926727
174Scapular winging (HP:0003691)1.40911380
175Alopecia of scalp (HP:0002293)1.40765766
176Flat cornea (HP:0007720)1.40142931
177Widely spaced teeth (HP:0000687)1.39927045
178Renal duplication (HP:0000075)1.39401960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.77397103
2CAMK1G2.97840770
3ACVR1B2.89967004
4BMPR1B2.81253702
5CAMK1D2.76937296
6PNCK2.61120997
7INSRR2.28334626
8MARK12.20981586
9ADRBK22.09778398
10PINK12.06245540
11SIK12.01046696
12NTRK32.00021244
13SIK21.98709450
14WNK31.85415851
15PDGFRA1.84788167
16TNIK1.74572094
17PRKD31.66701042
18CDK121.63228336
19STK391.61400447
20GRK11.57218164
21SGK21.54085123
22DMPK1.52935999
23STK381.41848833
24ICK1.41007518
25EPHB21.39333882
26LATS21.36867637
27TGFBR11.35980767
28SGK31.35890529
29RIPK11.32863798
30STK38L1.29967868
31BRD41.28350108
32OXSR11.25317216
33ADRBK11.24202657
34MAP3K41.23567772
35WNK11.20085362
36NUAK11.18395067
37ERBB31.14703735
38EPHA41.14570929
39TAOK31.11960617
40FGFR21.11665473
41FER1.11485264
42EPHA31.08764039
43NTRK21.07181131
44PDGFRB1.05159384
45PTK61.04798558
46TGFBR21.03958808
47SGK4941.01894527
48SGK2231.01894527
49STK30.99629577
50PAK60.97849908
51TYRO30.96102327
52MAPK130.93511298
53PRPF4B0.92965250
54MAPK150.91003346
55TTN0.89849056
56LMTK20.87233464
57DYRK20.86869893
58ZAK0.86462837
59FRK0.85746018
60PHKG10.85487504
61PHKG20.85487504
62BRSK20.85284100
63PTK2B0.84891607
64SGK10.84831473
65CAMK40.84815669
66NLK0.84171997
67KSR10.83823440
68DDR20.83580311
69ERBB20.83376384
70PRKAA20.83330072
71TIE10.83244029
72CSNK1A1L0.83051554
73CASK0.82707747
74CAMKK20.82673532
75TLK10.82083262
76PRKCG0.81865696
77PDK30.80594050
78PDK40.80594050
79AKT30.80356799
80MARK30.80271635
81BCR0.79084909
82CDC42BPA0.77292876
83BMX0.76906883
84MARK20.76422962
85PDK20.75291707
86NEK60.75111407
87PTK20.74770292
88SIK30.74585382
89CAMKK10.73444621
90RET0.72547329
91PKN10.72020456
92DAPK20.71581111
93JAK10.71570621
94MTOR0.70612067
95PRKAA10.69817186
96PIK3CA0.67894256
97MKNK20.66892665
98CHUK0.65564163
99MAP3K70.65469432
100ERBB40.63527311
101STK110.63391229
102TRPM70.62627030
103MET0.61804330
104PKN20.60841640
105WNK40.58186677
106MAP2K40.58046127
107PLK20.56780601
108ROCK10.56108963
109EIF2AK20.55689414
110FGFR30.55099993
111MAP3K60.53892990
112MUSK0.53766092
113MELK0.53235141
114PRKCE0.52746815
115IRAK10.51926926
116OBSCN0.51718889
117MAP2K10.51615310
118PRKCH0.50121031
119MAP2K70.48900701
120CAMK2A0.48856106
121MAPK100.48552508
122CSNK1G20.48397717
123PRKCZ0.48159493
124NEK20.45923863
125CSNK1D0.45853542
126PAK30.45821369
127DYRK1A0.45010553
128GSK3A0.44968001
129CAMK10.44883141
130CDK90.44835189
131RPS6KA60.42755490
132MAP4K20.42737104
133CDK50.42409079
134PIK3CG0.42132158
135CSNK1G10.42058522
136FGFR10.42029022
137PRKD10.41512249
138PRKG10.38455080
139MAPKAPK50.36000110
140MAP3K20.32703759

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00561423
2Phototransduction_Homo sapiens_hsa047441.96778218
3Linoleic acid metabolism_Homo sapiens_hsa005911.93224168
4Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.79106296
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.74124820
6Selenocompound metabolism_Homo sapiens_hsa004501.69755740
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69672128
8Dorso-ventral axis formation_Homo sapiens_hsa043201.65895344
9Butanoate metabolism_Homo sapiens_hsa006501.64290309
10Type II diabetes mellitus_Homo sapiens_hsa049301.61240656
11Lysine degradation_Homo sapiens_hsa003101.60607273
12Axon guidance_Homo sapiens_hsa043601.59821613
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54943250
14ABC transporters_Homo sapiens_hsa020101.52132931
15Dilated cardiomyopathy_Homo sapiens_hsa054141.50860788
16Adherens junction_Homo sapiens_hsa045201.50852575
17Ether lipid metabolism_Homo sapiens_hsa005651.41519840
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40152854
19ECM-receptor interaction_Homo sapiens_hsa045121.37636432
20Circadian entrainment_Homo sapiens_hsa047131.37333593
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33855467
22Nicotine addiction_Homo sapiens_hsa050331.32406782
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31865959
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31286683
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.31094946
26Tryptophan metabolism_Homo sapiens_hsa003801.30920082
27Focal adhesion_Homo sapiens_hsa045101.24106964
28Glutamatergic synapse_Homo sapiens_hsa047241.23901500
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23243133
30Renin secretion_Homo sapiens_hsa049241.20698890
31Fatty acid biosynthesis_Homo sapiens_hsa000611.20657208
32Basal cell carcinoma_Homo sapiens_hsa052171.19249552
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18848728
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15692125
35Endometrial cancer_Homo sapiens_hsa052131.14010282
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.12408659
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.08574502
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.06345294
39Glioma_Homo sapiens_hsa052141.05607971
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04681432
41cAMP signaling pathway_Homo sapiens_hsa040241.02785371
42Morphine addiction_Homo sapiens_hsa050321.02389146
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02315375
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01487187
45Amoebiasis_Homo sapiens_hsa051461.00421177
46Notch signaling pathway_Homo sapiens_hsa043300.95753920
47ErbB signaling pathway_Homo sapiens_hsa040120.95711607
48Long-term potentiation_Homo sapiens_hsa047200.95437048
49Cholinergic synapse_Homo sapiens_hsa047250.95206287
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93050441
51Ovarian steroidogenesis_Homo sapiens_hsa049130.92881492
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92433834
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90112905
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89963514
55Oxytocin signaling pathway_Homo sapiens_hsa049210.89831422
56GABAergic synapse_Homo sapiens_hsa047270.89620641
57Nitrogen metabolism_Homo sapiens_hsa009100.89308916
58Estrogen signaling pathway_Homo sapiens_hsa049150.88932598
59Proteoglycans in cancer_Homo sapiens_hsa052050.88208696
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88130659
61Hedgehog signaling pathway_Homo sapiens_hsa043400.88059960
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87553769
63Calcium signaling pathway_Homo sapiens_hsa040200.87522232
64MicroRNAs in cancer_Homo sapiens_hsa052060.87343696
65Histidine metabolism_Homo sapiens_hsa003400.87009732
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.84973625
67Hippo signaling pathway_Homo sapiens_hsa043900.84912765
68Small cell lung cancer_Homo sapiens_hsa052220.84725791
69Insulin resistance_Homo sapiens_hsa049310.83641056
70Insulin secretion_Homo sapiens_hsa049110.83181021
71Caffeine metabolism_Homo sapiens_hsa002320.82435761
72Salivary secretion_Homo sapiens_hsa049700.82374621
73Melanogenesis_Homo sapiens_hsa049160.82139427
74Wnt signaling pathway_Homo sapiens_hsa043100.81868416
75Olfactory transduction_Homo sapiens_hsa047400.81144677
76Gastric acid secretion_Homo sapiens_hsa049710.80398408
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79955315
78Viral myocarditis_Homo sapiens_hsa054160.79921175
79Choline metabolism in cancer_Homo sapiens_hsa052310.79741356
80Amphetamine addiction_Homo sapiens_hsa050310.77590802
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77465140
82Renal cell carcinoma_Homo sapiens_hsa052110.77079108
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76700607
84Long-term depression_Homo sapiens_hsa047300.76668524
85Rap1 signaling pathway_Homo sapiens_hsa040150.75928973
86Cocaine addiction_Homo sapiens_hsa050300.75920077
87GnRH signaling pathway_Homo sapiens_hsa049120.75871195
88Melanoma_Homo sapiens_hsa052180.75719814
89Thyroid hormone synthesis_Homo sapiens_hsa049180.75591266
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.75532141
91Taste transduction_Homo sapiens_hsa047420.75495023
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75174693
93Prostate cancer_Homo sapiens_hsa052150.73593263
94Glycerolipid metabolism_Homo sapiens_hsa005610.72927149
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72329427
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72131017
97mTOR signaling pathway_Homo sapiens_hsa041500.72123213
98Chronic myeloid leukemia_Homo sapiens_hsa052200.72039934
99Protein digestion and absorption_Homo sapiens_hsa049740.70885489
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70480423
101Dopaminergic synapse_Homo sapiens_hsa047280.69755906
102Chemical carcinogenesis_Homo sapiens_hsa052040.68462356
103Ras signaling pathway_Homo sapiens_hsa040140.68376424
104TGF-beta signaling pathway_Homo sapiens_hsa043500.68104542
105Circadian rhythm_Homo sapiens_hsa047100.66642677
106Staphylococcus aureus infection_Homo sapiens_hsa051500.66575445
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66402363
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.65982317
109Gap junction_Homo sapiens_hsa045400.65710913
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65276671
111Colorectal cancer_Homo sapiens_hsa052100.65144978
112MAPK signaling pathway_Homo sapiens_hsa040100.64189767
113Propanoate metabolism_Homo sapiens_hsa006400.63988291
114Retinol metabolism_Homo sapiens_hsa008300.63727628
115Glucagon signaling pathway_Homo sapiens_hsa049220.63441116
116Arachidonic acid metabolism_Homo sapiens_hsa005900.62990180
117Mineral absorption_Homo sapiens_hsa049780.62617868
118Bile secretion_Homo sapiens_hsa049760.61113324
119AMPK signaling pathway_Homo sapiens_hsa041520.60478326
120Osteoclast differentiation_Homo sapiens_hsa043800.59616839
121Serotonergic synapse_Homo sapiens_hsa047260.59265640
122Toxoplasmosis_Homo sapiens_hsa051450.58642355
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58456674
124beta-Alanine metabolism_Homo sapiens_hsa004100.58257384
125Tight junction_Homo sapiens_hsa045300.58022021
126Insulin signaling pathway_Homo sapiens_hsa049100.58000513
127Pancreatic cancer_Homo sapiens_hsa052120.57439978
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56795526
129Basal transcription factors_Homo sapiens_hsa030220.55511785
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55474910
131Pathways in cancer_Homo sapiens_hsa052000.55051741
132Prolactin signaling pathway_Homo sapiens_hsa049170.54659947
133FoxO signaling pathway_Homo sapiens_hsa040680.54211179
134PPAR signaling pathway_Homo sapiens_hsa033200.53695433
135Complement and coagulation cascades_Homo sapiens_hsa046100.50960479
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50836415
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49874583
138Pancreatic secretion_Homo sapiens_hsa049720.46887920
139Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43586589

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