SATB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive T cell selection (GO:0043368)9.03730545
2V(D)J recombination (GO:0033151)8.97406727
3negative T cell selection (GO:0043383)8.68460840
4negative regulation of thymocyte apoptotic process (GO:0070244)7.79562060
5regulation of gamma-delta T cell differentiation (GO:0045586)7.73773829
6T cell selection (GO:0045058)7.72351102
7positive regulation of interleukin-2 biosynthetic process (GO:0045086)7.63881671
8positive regulation of gamma-delta T cell activation (GO:0046645)7.35264322
9regulation of gamma-delta T cell activation (GO:0046643)6.90180469
10interferon-gamma production (GO:0032609)6.50092141
11negative thymic T cell selection (GO:0045060)6.43611959
12negative regulation of cell killing (GO:0031342)6.23551260
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.23551260
14positive thymic T cell selection (GO:0045059)6.00076316
15T cell receptor signaling pathway (GO:0050852)5.84263037
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.77249271
17thymic T cell selection (GO:0045061)5.63128499
18regulation of interleukin-2 biosynthetic process (GO:0045076)5.49600525
19positive regulation of interleukin-2 production (GO:0032743)5.38169482
20regulation of thymocyte apoptotic process (GO:0070243)5.10957248
21response to interleukin-15 (GO:0070672)5.10824797
22antigen receptor-mediated signaling pathway (GO:0050851)4.80512629
23T cell costimulation (GO:0031295)4.70228896
24* T cell differentiation (GO:0030217)4.62721479
25lymphocyte costimulation (GO:0031294)4.60801007
26cellular response to interleukin-15 (GO:0071350)4.59493679
27modulation by virus of host process (GO:0019054)4.56395516
28somatic cell DNA recombination (GO:0016444)4.49163699
29somatic diversification of immune receptors via germline recombination within a single locus (GO:0004.49163699
30* alpha-beta T cell differentiation (GO:0046632)4.45635308
31regulation of isotype switching to IgG isotypes (GO:0048302)4.42034663
32mucosal-associated lymphoid tissue development (GO:0048537)4.36406581
33Peyers patch development (GO:0048541)4.36406581
34T cell homeostasis (GO:0043029)4.31510371
35* alpha-beta T cell activation (GO:0046631)4.21256593
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14490677
37regulation of interleukin-2 production (GO:0032663)4.09651159
38mast cell activation (GO:0045576)4.09612058
39negative regulation of T cell apoptotic process (GO:0070233)4.08189080
40somatic diversification of immune receptors (GO:0002200)4.06444230
41regulation of T cell receptor signaling pathway (GO:0050856)3.99053729
42positive regulation of calcium-mediated signaling (GO:0050850)3.96315968
43modulation by symbiont of host cellular process (GO:0044068)3.86255763
44regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.83766842
45regulation of T cell tolerance induction (GO:0002664)3.81524471
46regulation of regulatory T cell differentiation (GO:0045589)3.80801971
47regulation of defense response to virus by virus (GO:0050690)3.79100945
48negative regulation of lymphocyte mediated immunity (GO:0002707)3.65217915
49mast cell degranulation (GO:0043303)3.64493635
50mast cell activation involved in immune response (GO:0002279)3.64493635
51T cell lineage commitment (GO:0002360)3.58310300
52lymphocyte homeostasis (GO:0002260)3.49791848
53T cell differentiation in thymus (GO:0033077)3.46949845
54* T cell activation (GO:0042110)3.45766815
55positive regulation of natural killer cell mediated immunity (GO:0002717)3.43647426
56positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.43647426
57regulation of interleukin-12 biosynthetic process (GO:0045075)3.42360413
58positive regulation of granulocyte differentiation (GO:0030854)3.38685480
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.38561531
60regulation of alpha-beta T cell proliferation (GO:0046640)3.35524640
61regulation of granulocyte differentiation (GO:0030852)3.35508195
62regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.33636929
63regulation of natural killer cell mediated immunity (GO:0002715)3.33636929
64genitalia morphogenesis (GO:0035112)3.33314796
65negative regulation of lymphocyte apoptotic process (GO:0070229)3.29315547
66negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.28295762
67negative regulation of T-helper cell differentiation (GO:0045623)3.28295762
68immune response-activating cell surface receptor signaling pathway (GO:0002429)3.25365628
69negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.24996038
70regulation of B cell receptor signaling pathway (GO:0050855)3.23884569
71* lymphocyte differentiation (GO:0030098)3.21922705
72positive regulation of T cell differentiation in thymus (GO:0033089)3.21410674
73tolerance induction (GO:0002507)3.16870914
74positive regulation of alpha-beta T cell proliferation (GO:0046641)3.13292507
75regulation of B cell differentiation (GO:0045577)3.12681942
76negative regulation of leukocyte mediated immunity (GO:0002704)3.11240694
77regulation of T cell differentiation (GO:0045580)3.09566185
78phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.07873407
79histone H3-K36 demethylation (GO:0070544)3.07390857
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05725885
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05725885
82positive regulation of isotype switching (GO:0045830)3.00727437
83regulation of tolerance induction (GO:0002643)2.99585873
84negative regulation of adaptive immune response (GO:0002820)2.99081134
85leukocyte homeostasis (GO:0001776)2.98978562
86histone H3-K4 trimethylation (GO:0080182)2.96985188
87* CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.96643146
88* activated T cell proliferation (GO:0050798)2.93638012
89positive regulation of T cell activation (GO:0050870)2.92364191
90generation of neurons (GO:0048699)2.92092968
91positive regulation of tolerance induction (GO:0002645)2.91066947
92alpha-beta T cell differentiation involved in immune response (GO:0002293)2.90457746
93alpha-beta T cell activation involved in immune response (GO:0002287)2.90457746
94T cell differentiation involved in immune response (GO:0002292)2.90457746
95positive regulation of T cell differentiation (GO:0045582)2.89527361
96cellular extravasation (GO:0045123)2.87879359
97histone monoubiquitination (GO:0010390)2.87867295
98negative regulation of T cell receptor signaling pathway (GO:0050860)2.86610548
99leukocyte aggregation (GO:0070486)2.85051159
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84609736
101B cell receptor signaling pathway (GO:0050853)2.84215548
102negative regulation of T cell mediated immunity (GO:0002710)2.82929875
103negative regulation of erythrocyte differentiation (GO:0045647)2.80647485
104positive regulation of cell killing (GO:0031343)2.79308699
105B cell proliferation (GO:0042100)2.78463438
106CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.78408595
107T-helper cell differentiation (GO:0042093)2.78408595
108regulation of interleukin-4 production (GO:0032673)2.77852238
109positive regulation of alpha-beta T cell activation (GO:0046635)2.76472652
110cellular response to interleukin-4 (GO:0071353)2.75917435
111positive regulation of natural killer cell differentiation (GO:0032825)2.74086418
112positive regulation of interleukin-4 production (GO:0032753)2.73670067
113* CD4-positive, alpha-beta T cell activation (GO:0035710)2.73262407
114regulation of T cell activation (GO:0050863)2.73061286
115negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.72929603
116positive regulation of B cell differentiation (GO:0045579)2.72735765
117regulation of alpha-beta T cell activation (GO:0046634)2.70923821
118positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.66309561
119T cell migration (GO:0072678)2.66201958
120antigen processing and presentation of endogenous antigen (GO:0019883)2.65165717
121lymph node development (GO:0048535)2.64737914
122regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.62275691
123response to muramyl dipeptide (GO:0032495)2.61428258
124regulation of germinal center formation (GO:0002634)2.59435657
125positive regulation of alpha-beta T cell differentiation (GO:0046638)2.58960164
126regulation of alpha-beta T cell differentiation (GO:0046637)2.57510661
127positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.56005852
128negative regulation of immunoglobulin mediated immune response (GO:0002890)2.51482820
129negative regulation of B cell mediated immunity (GO:0002713)2.51482820
130regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.50178418
131positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.50150175
132natural killer cell differentiation (GO:0001779)2.49572869
133positive regulation of Rap GTPase activity (GO:0032854)2.47801280
134* T cell proliferation (GO:0042098)2.46130225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.89307716
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.70862257
3MYC_22102868_ChIP-Seq_BL_Human4.51543074
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.43985201
5RUNX_20019798_ChIP-Seq_JUKART_Human4.35785237
6FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse4.23327477
7E2F7_22180533_ChIP-Seq_HELA_Human3.89636543
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.71773341
9* MYB_26560356_Chip-Seq_TH2_Human3.48604044
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.95359159
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.89751899
12* UTX_26944678_Chip-Seq_JUKART_Human2.83606440
13KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.68119443
14* MAF_26560356_Chip-Seq_TH1_Human2.65911584
15TCF7_22412390_ChIP-Seq_EML_Mouse2.65190606
16GATA3_27048872_Chip-Seq_THYMUS_Human2.61737096
17MYB_26560356_Chip-Seq_TH1_Human2.60222059
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43543097
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42316504
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.32431530
21* KDM2B_26808549_Chip-Seq_DND41_Human2.27200828
22* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.27130819
23* VDR_21846776_ChIP-Seq_THP-1_Human2.21359114
24EZH2_22144423_ChIP-Seq_EOC_Human2.18994015
25CIITA_25753668_ChIP-Seq_RAJI_Human2.18009734
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.11412750
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03605866
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.99430367
29SCL_19346495_ChIP-Seq_HPC-7_Human1.96563936
30RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.89122585
31GBX2_23144817_ChIP-Seq_PC3_Human1.86724988
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.84722415
33MAF_26560356_Chip-Seq_TH2_Human1.77702610
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.74229056
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73891619
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73666866
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72078075
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71781433
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.68368427
40* VDR_24763502_ChIP-Seq_THP-1_Human1.67960437
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65750792
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.64496854
43DROSHA_22980978_ChIP-Seq_HELA_Human1.56358973
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54189363
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53380032
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.51206131
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51014133
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.48512597
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.47519348
50* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46392841
51AR_21572438_ChIP-Seq_LNCaP_Human1.43810765
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43400346
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40538220
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38860532
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33147664
56PKCTHETA_26484144_Chip-Seq_BREAST_Human1.33088333
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29439552
58SPI1_23127762_ChIP-Seq_K562_Human1.27444131
59IGF1R_20145208_ChIP-Seq_DFB_Human1.23904642
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22991734
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19900776
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19806157
63* REST_21632747_ChIP-Seq_MESCs_Mouse1.19489056
64* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18984505
65* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18984505
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17833585
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17801148
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13794277
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13659451
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13553059
71* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12792741
72* ER_23166858_ChIP-Seq_MCF-7_Human1.12233490
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11946036
74* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11292092
75* RARB_27405468_Chip-Seq_BRAIN_Mouse1.09194185
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.09132296
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09113238
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08683456
79GATA1_22025678_ChIP-Seq_K562_Human1.07571428
80SPI1_23547873_ChIP-Seq_NB4_Human1.04028572
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.01169991
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.00543054
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00515126
84* P300_19829295_ChIP-Seq_ESCs_Human1.00500040
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00255560
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00043528
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99670849
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99231106
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98778517
90SMAD4_21799915_ChIP-Seq_A2780_Human0.98213416
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97817945
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97328049
93* PRDM14_20953172_ChIP-Seq_ESCs_Human0.97154121
94PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96413233
95* GATA3_26560356_Chip-Seq_TH2_Human0.96012356
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95501166
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95243786
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95196744
99FUS_26573619_Chip-Seq_HEK293_Human0.94162568
100BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93174085
101OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92677551
102EWS_26573619_Chip-Seq_HEK293_Human0.92173217
103ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91692893
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91485081
105* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90971150
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90937550
107RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90922818
108KDM2B_26808549_Chip-Seq_REH_Human0.90592391
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90066471
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89435027
111TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89263356
112* TCF4_23295773_ChIP-Seq_U87_Human0.88498565
113* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.88384710
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88264499
115P53_22387025_ChIP-Seq_ESCs_Mouse0.87911585
116BCAT_22108803_ChIP-Seq_LS180_Human0.87712017
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87494716
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87339444
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.87252653
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87022708
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86884357
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86814701
123NFE2_27457419_Chip-Seq_LIVER_Mouse0.86369459
124* STAT3_23295773_ChIP-Seq_U87_Human0.86242737
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85591242
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85441325
127* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84285586
128GATA3_26560356_Chip-Seq_TH1_Human0.82755945
129PU_27001747_Chip-Seq_BMDM_Mouse0.82622828
130KDM5A_27292631_Chip-Seq_BREAST_Human0.82358751
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79732002
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77829498
133WDR5_24793694_ChIP-Seq_LNCAP_Human0.75758523
134SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.75653313
135KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.75041337
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.74135926
137FOXP3_21729870_ChIP-Seq_TREG_Human0.74078000
138TP63_19390658_ChIP-ChIP_HaCaT_Human0.73220595
139VDR_24787735_ChIP-Seq_THP-1_Human0.71685589
140VDR_23849224_ChIP-Seq_CD4+_Human0.71573416
141* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.70233206
142YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.69498880
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69116065
144* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.68932829
145SALL1_21062744_ChIP-ChIP_HESCs_Human0.68783669
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.68572877
147ETS1_22383799_ChIP-Seq_G1ME_Mouse0.68242217
148BP1_19119308_ChIP-ChIP_Hs578T_Human0.65764180
149FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.65427004
150TAF15_26573619_Chip-Seq_HEK293_Human0.65362485
151* SMRT_27268052_Chip-Seq_Bcells_Human0.65279331
152CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.65027396
153RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.64672910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.59087885
2MP0002166_altered_tumor_susceptibility4.42189036
3MP0005671_abnormal_response_to3.93642663
4MP0005409_darkened_coat_color3.60332131
5* MP0000703_abnormal_thymus_morphology3.57523462
6MP0002006_tumorigenesis3.45583961
7MP0000685_abnormal_immune_system2.96914017
8MP0002132_abnormal_respiratory_system2.81663759
9* MP0002398_abnormal_bone_marrow2.65464079
10MP0003724_increased_susceptibility_to2.62275206
11MP0001800_abnormal_humoral_immune2.54360005
12MP0005387_immune_system_phenotype2.49754747
13MP0001790_abnormal_immune_system2.49754747
14MP0010155_abnormal_intestine_physiology2.32836042
15MP0001835_abnormal_antigen_presentation2.27683170
16MP0004947_skin_inflammation2.22107334
17* MP0002722_abnormal_immune_system2.18991488
18* MP0000716_abnormal_immune_system2.14891331
19MP0004808_abnormal_hematopoietic_stem2.14045281
20* MP0002420_abnormal_adaptive_immunity2.13348613
21MP0005000_abnormal_immune_tolerance2.12925769
22MP0009333_abnormal_splenocyte_physiolog2.10902130
23MP0002723_abnormal_immune_serum2.08545088
24MP0003866_abnormal_defecation2.08005983
25* MP0001819_abnormal_immune_cell2.07535856
26MP0002396_abnormal_hematopoietic_system2.03063871
27MP0000015_abnormal_ear_pigmentation2.01886597
28MP0002405_respiratory_system_inflammati2.01777133
29MP0002933_joint_inflammation2.00357486
30* MP0000689_abnormal_spleen_morphology1.98326347
31MP0005174_abnormal_tail_pigmentation1.95161439
32MP0009785_altered_susceptibility_to1.92928804
33MP0001849_ear_inflammation1.82086548
34MP0003300_gastrointestinal_ulcer1.81837031
35MP0002452_abnormal_antigen_presenting1.79628369
36MP0002095_abnormal_skin_pigmentation1.76451908
37MP0010094_abnormal_chromosome_stability1.70115492
38* MP0002429_abnormal_blood_cell1.65493969
39MP0003787_abnormal_imprinting1.60821789
40MP0006082_CNS_inflammation1.56608597
41MP0001501_abnormal_sleep_pattern1.48526679
42MP0004859_abnormal_synaptic_plasticity1.48240098
43MP0008961_abnormal_basal_metabolism1.48037084
44MP0005025_abnormal_response_to1.43598538
45MP0004510_myositis1.40236976
46MP0009278_abnormal_bone_marrow1.39468575
47MP0002277_abnormal_respiratory_mucosa1.36714321
48MP0008057_abnormal_DNA_replication1.34205898
49MP0003303_peritoneal_inflammation1.25416012
50MP0001986_abnormal_taste_sensitivity1.22303470
51MP0005076_abnormal_cell_differentiation1.21472749
52MP0002009_preneoplasia1.18926991
53MP0002148_abnormal_hypersensitivity_rea1.18181595
54MP0001873_stomach_inflammation1.17705087
55MP0004142_abnormal_muscle_tone1.15766000
56MP0001968_abnormal_touch/_nociception1.15730895
57MP0001486_abnormal_startle_reflex1.15418238
58MP0005397_hematopoietic_system_phenotyp1.15164844
59MP0001545_abnormal_hematopoietic_system1.15164844
60MP0003436_decreased_susceptibility_to1.14234491
61MP0005310_abnormal_salivary_gland1.13917496
62MP0001845_abnormal_inflammatory_respons1.12370769
63MP0001853_heart_inflammation1.07193070
64MP0002638_abnormal_pupillary_reflex1.05594949
65MP0004742_abnormal_vestibular_system1.05348683
66MP0002272_abnormal_nervous_system1.05334767
67MP0004381_abnormal_hair_follicle1.03716145
68MP0003646_muscle_fatigue1.00841973
69MP0003635_abnormal_synaptic_transmissio0.95301775
70MP0004484_altered_response_of0.94974279
71MP0002075_abnormal_coat/hair_pigmentati0.93359918
72MP0002019_abnormal_tumor_incidence0.93046226
73MP0003172_abnormal_lysosome_physiology0.92878688
74MP0010352_gastrointestinal_tract_polyps0.92568327
75MP0004270_analgesia0.91212127
76* MP0008569_lethality_at_weaning0.91065252
77MP0001879_abnormal_lymphatic_vessel0.89466242
78MP0001188_hyperpigmentation0.86207045
79MP0008877_abnormal_DNA_methylation0.84719325
80MP0001533_abnormal_skeleton_physiology0.84335059
81MP0000569_abnormal_digit_pigmentation0.84128631
82* MP0002067_abnormal_sensory_capabilities0.83872630
83MP0004130_abnormal_muscle_cell0.82615633
84MP0003690_abnormal_glial_cell0.81360444
85MP0002419_abnormal_innate_immunity0.80352194
86MP0008770_decreased_survivor_rate0.79581373
87MP0000490_abnormal_crypts_of0.78845430
88MP0000920_abnormal_myelination0.78767144
89MP0000465_gastrointestinal_hemorrhage0.74820725
90MP0002693_abnormal_pancreas_physiology0.73886372
91MP0003879_abnormal_hair_cell0.72827780
92MP0005464_abnormal_platelet_physiology0.72825177
93MP0002254_reproductive_system_inflammat0.72362161
94MP0002138_abnormal_hepatobiliary_system0.72288798
95MP0005423_abnormal_somatic_nervous0.71516305
96MP0002735_abnormal_chemical_nociception0.71158392
97MP0003880_abnormal_central_pattern0.71133411
98MP0005535_abnormal_body_temperature0.69689661
99MP0002998_abnormal_bone_remodeling0.69633213
100MP0000858_altered_metastatic_potential0.69255059
101MP0003077_abnormal_cell_cycle0.68817989
102MP0002736_abnormal_nociception_after0.68391004
103MP0001970_abnormal_pain_threshold0.67798195
104MP0008995_early_reproductive_senescence0.65754557
105MP0002083_premature_death0.65274857
106MP0000604_amyloidosis0.64940014
107MP0009046_muscle_twitch0.64589841
108MP0002822_catalepsy0.63871811
109MP0001186_pigmentation_phenotype0.63364378
110MP0004885_abnormal_endolymph0.62550256
111MP0003633_abnormal_nervous_system0.61487751
112MP0009745_abnormal_behavioral_response0.60230439
113MP0002064_seizures0.59585244
114MP0000383_abnormal_hair_follicle0.58884963
115MP0006035_abnormal_mitochondrial_morpho0.58685167
116MP0002063_abnormal_learning/memory/cond0.58202865
117MP0005386_behavior/neurological_phenoty0.55611426
118MP0004924_abnormal_behavior0.55611426
119MP0001851_eye_inflammation0.54929087
120MP0003959_abnormal_lean_body0.53641838
121MP0001191_abnormal_skin_condition0.52014093
122MP0005075_abnormal_melanosome_morpholog0.51237774
123MP0003448_altered_tumor_morphology0.50025333
124MP0000367_abnormal_coat/_hair0.49435229
125MP0001243_abnormal_dermal_layer0.47785224
126MP0000350_abnormal_cell_proliferation0.45414164
127MP0002572_abnormal_emotion/affect_behav0.40785234
128MP0002876_abnormal_thyroid_physiology0.40153521
129MP0001784_abnormal_fluid_regulation0.39778237
130MP0003693_abnormal_embryo_hatching0.39620890
131MP0008007_abnormal_cellular_replicative0.39312521

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)9.57266078
2Abnormality of B cell number (HP:0010975)9.43492451
3B lymphocytopenia (HP:0010976)9.43492451
4Panhypogammaglobulinemia (HP:0003139)8.50618839
5Severe combined immunodeficiency (HP:0004430)8.30700124
6Hypoplasia of the thymus (HP:0000778)8.08150688
7Thyroiditis (HP:0100646)7.91499933
8Combined immunodeficiency (HP:0005387)7.08116543
9Eosinophilia (HP:0001880)6.46582453
10Recurrent viral infections (HP:0004429)6.34240100
11Hypoproteinemia (HP:0003075)5.59588686
12Abnormality of T cells (HP:0002843)5.35489824
13Granulocytopenia (HP:0001913)5.18923340
14Abnormality of eosinophils (HP:0001879)5.13069943
15Recurrent fungal infections (HP:0002841)4.84793563
16IgG deficiency (HP:0004315)4.67544774
17Abnormality of the fingertips (HP:0001211)3.85488912
18Papilledema (HP:0001085)3.84501480
19Leukocytosis (HP:0001974)3.71334970
20Erythroderma (HP:0001019)3.42204523
21Stomach cancer (HP:0012126)2.98227614
22Optic neuritis (HP:0100653)2.94182279
23Retrobulbar optic neuritis (HP:0100654)2.94182279
24Aplasia/Hypoplasia of the thymus (HP:0010515)2.84633102
25Chronic mucocutaneous candidiasis (HP:0002728)2.84179489
26Recurrent cutaneous fungal infections (HP:0011370)2.84179489
27Stomatitis (HP:0010280)2.70224294
28Meningitis (HP:0001287)2.67350045
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.66074503
30Chronic diarrhea (HP:0002028)2.58851676
31Orchitis (HP:0100796)2.51657550
32Progressive cerebellar ataxia (HP:0002073)2.49464225
33Abnormality of the thymus (HP:0000777)2.44861371
34Volvulus (HP:0002580)2.44500982
35Lymphoma (HP:0002665)2.42486882
36Focal motor seizures (HP:0011153)2.38342211
37Spontaneous hematomas (HP:0007420)2.35991741
38IgM deficiency (HP:0002850)2.35492320
39Hyperventilation (HP:0002883)2.31714319
40Acute lymphatic leukemia (HP:0006721)2.24115859
41Keratoconjunctivitis (HP:0001096)2.23533461
42Elevated erythrocyte sedimentation rate (HP:0003565)2.21712283
43Keratoconjunctivitis sicca (HP:0001097)2.21439724
44Neoplasm of the tracheobronchial system (HP:0100552)2.20461957
45Prolonged bleeding time (HP:0003010)2.20316169
46Recurrent bacterial skin infections (HP:0005406)2.20124472
47Subaortic stenosis (HP:0001682)2.19816207
48Abnormality of the left ventricular outflow tract (HP:0011103)2.19816207
49Vasculitis (HP:0002633)2.14916723
50Verrucae (HP:0200043)2.14779298
51Papilloma (HP:0012740)2.14779298
52Recurrent abscess formation (HP:0002722)2.07278044
53Cellular immunodeficiency (HP:0005374)2.05061822
54Recurrent bronchitis (HP:0002837)2.04238560
55Hypochromic microcytic anemia (HP:0004840)2.03862561
56Basal cell carcinoma (HP:0002671)2.01254789
57Bicuspid aortic valve (HP:0001647)2.00446810
58Alveolar cell carcinoma (HP:0006519)2.00090406
59T lymphocytopenia (HP:0005403)10.1697043
60Genetic anticipation (HP:0003743)1.98276403
61Chronic otitis media (HP:0000389)1.92103220
62Gastrointestinal infarctions (HP:0005244)1.91080704
63Congenital stationary night blindness (HP:0007642)1.90564999
64Deep philtrum (HP:0002002)1.87971162
65Peripheral hypomyelination (HP:0007182)1.87576535
66Visual hallucinations (HP:0002367)1.86647547
67Broad-based gait (HP:0002136)1.85606954
68Gastrointestinal inflammation (HP:0004386)1.84984346
69Inflammation of the large intestine (HP:0002037)1.84525673
70Absent speech (HP:0001344)1.82440679
71Epileptic encephalopathy (HP:0200134)1.81867866
72Lymphopenia (HP:0001888)1.81659057
73Abnormal hair whorl (HP:0010721)1.81490407
74Pulmonary embolism (HP:0002204)1.80721690
75Dynein arm defect of respiratory motile cilia (HP:0012255)1.80230762
76Absent/shortened dynein arms (HP:0200106)1.80230762
77Focal seizures (HP:0007359)1.79039177
78Widely spaced teeth (HP:0000687)1.77708073
79Chronic sinusitis (HP:0011109)1.76666570
80Obstructive sleep apnea (HP:0002870)1.74068568
81Abnormality of cells of the lymphoid lineage (HP:0012140)1.72950857
82Sepsis (HP:0100806)1.72391355
83Asplenia (HP:0001746)1.71484502
84Increased CSF protein (HP:0002922)1.71097939
85Encephalitis (HP:0002383)1.67263474
86Muscle fiber inclusion bodies (HP:0100299)1.66866288
87Joint swelling (HP:0001386)1.66620374
88Muscle hypertrophy of the lower extremities (HP:0008968)1.64872011
89Agammaglobulinemia (HP:0004432)1.63203966
90Pustule (HP:0200039)1.63172530
91Abnormality of the columella (HP:0009929)1.63011601
92Slow saccadic eye movements (HP:0000514)1.61621520
93IgA deficiency (HP:0002720)1.60192556
94Macroorchidism (HP:0000053)1.58359312
95Abnormality of T cell physiology (HP:0011840)1.55695218
96Cutis marmorata (HP:0000965)1.51791209
97Long eyelashes (HP:0000527)1.50683700
98Myositis (HP:0100614)1.47591445
99Nasal polyposis (HP:0100582)1.47515369
100Bronchiectasis (HP:0002110)1.45759271
101Autoimmune hemolytic anemia (HP:0001890)1.44703299
102Heterotopia (HP:0002282)1.44408182
103Acute myeloid leukemia (HP:0004808)1.42626880
104Urinary urgency (HP:0000012)1.42561868
105Prominent nose (HP:0000448)1.40122259
106Sparse lateral eyebrow (HP:0005338)1.38575502
107Wide intermamillary distance (HP:0006610)1.35437598
108Mediastinal lymphadenopathy (HP:0100721)1.34586720
109Hyperacusis (HP:0010780)1.32859126
110Recurrent sinusitis (HP:0011108)1.32318937
111Atonic seizures (HP:0010819)1.31762601
112Increased IgM level (HP:0003496)1.30943269
113Autoimmune thrombocytopenia (HP:0001973)1.30934175
114Increased density of long bones (HP:0006392)1.29085975
115Eczematoid dermatitis (HP:0000976)1.28120403
116Amyotrophic lateral sclerosis (HP:0007354)1.27418288
117Narrow palate (HP:0000189)1.25909244
118Dislocated radial head (HP:0003083)1.25353394
119Trigonocephaly (HP:0000243)1.24986332
120Recurrent otitis media (HP:0000403)1.24958711
121Impaired vibration sensation in the lower limbs (HP:0002166)1.23487640
122Hemoptysis (HP:0002105)1.23403747
123Abnormality of oral frenula (HP:0000190)1.23182803
124Abnormality of binocular vision (HP:0011514)1.22669674
125Diplopia (HP:0000651)1.22669674
126Deep palmar crease (HP:0006191)1.22552212
127Mitral regurgitation (HP:0001653)1.21618545
128Recurrent skin infections (HP:0001581)1.21570398
129Sacral dimple (HP:0000960)1.19806246
130Truncal obesity (HP:0001956)1.18390945
131Cheilitis (HP:0100825)1.17819061
132Hemiplegia (HP:0002301)1.17724868
133Ureteral stenosis (HP:0000071)1.17672282
134Lip pit (HP:0100267)1.17350238
135Chest pain (HP:0100749)1.16887428
136Increased IgE level (HP:0003212)1.16325546
137Febrile seizures (HP:0002373)1.16219054
138Abnormality of the radial head (HP:0003995)1.16095157
139Pulmonary infiltrates (HP:0002113)1.16034176
140Entropion (HP:0000621)1.15279417
141Obsessive-compulsive behavior (HP:0000722)1.14474250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.93883910
2MAP4K14.76523004
3ITK3.01611725
4GRK62.70031665
5ZAP702.56856063
6TAOK32.10453798
7YES12.00402058
8SYK1.98902195
9PASK1.94996141
10MAPK71.91642768
11EEF2K1.90425615
12PDGFRB1.88635456
13JAK31.87885287
14NLK1.80666082
15FGFR31.77570271
16MAP3K71.73731051
17KIT1.69017698
18CDK121.67918025
19FRK1.65308434
20STK101.63222231
21LCK1.59527381
22CAMKK21.59305777
23OBSCN1.56841420
24MST41.56749489
25HCK1.53552548
26MAP3K101.52400838
27SIK21.50704249
28FGFR41.49235006
29TEC1.41778827
30PRKCQ1.40167232
31CSNK1A1L1.38265683
32MAPK131.31270002
33PKN21.30412175
34MARK21.24862474
35PIK3CG1.22549779
36MAPK121.16103700
37CSNK1G21.15096832
38MAP2K31.14011242
39FGFR21.13624408
40TYK21.12784915
41CSNK1G31.11475136
42PINK11.08962098
43BRD41.06712376
44BTK1.02059320
45NTRK21.00948868
46CSK1.00194352
47PRKCH0.96690177
48CASK0.96372485
49TAOK10.94849953
50MAP3K130.94323224
51CAMKK10.93352830
52BMPR20.92817669
53SGK2230.91788718
54SGK4940.91788718
55CSNK1G10.89867869
56IKBKB0.87373118
57DAPK20.87156275
58TYRO30.85943772
59CDK190.85829400
60HIPK20.84937007
61SGK30.83070657
62CDK30.82264272
63IKBKE0.81716840
64LRRK20.79972481
65TNIK0.79155203
66MAPK150.79040363
67MAPK40.77081720
68ALK0.76072921
69CAMK10.75944037
70JAK10.74903505
71MARK30.72396475
72RIPK40.71229749
73BLK0.70179294
74MAP3K140.66958344
75CAMK40.66481342
76IRAK40.65403787
77SIK30.65268651
78JAK20.64520197
79RET0.64079192
80FES0.63692616
81FLT30.63154490
82MAP2K60.61748867
83EPHA40.61537296
84PIM10.61397153
85CLK10.58779478
86SGK10.58424713
87FYN0.56913285
88IRAK10.56517943
89MAP2K40.56138918
90WNK30.55842217
91TBK10.55623931
92SGK20.54548691
93RAF10.53357848
94PDK10.52684664
95PRPF4B0.52463589
96CDC70.52354343
97MARK10.51350322
98EPHA30.50879507
99DMPK0.49964171
100CAMK1G0.48077860
101CDK90.48025370
102MELK0.47685380
103CHUK0.46784249
104MAP3K40.45490917
105EPHB10.45202630
106TNK20.44556468
107MAP3K10.44071575
108MAP3K60.42575075
109NUAK10.42162246
110ACVR1B0.42006961
111PHKG20.41554830
112PHKG10.41554830
113WNK10.41038104
114ADRBK20.40728686
115DYRK1B0.40160234
116FGFR10.39774330
117CDK60.39594449
118TSSK60.38966009
119RPS6KB10.37996394
120CDK40.37942561
121CCNB10.37639006
122MAPK80.36695508
123MAPK90.36408167
124INSR0.36391255
125CSNK1D0.35528988
126CHEK10.32866429
127RPS6KA40.32181531
128LYN0.31895163
129PRKD20.31502187
130STK110.31469130
131UHMK10.29611036
132MKNK20.27811457
133DYRK1A0.26373963
134NTRK30.25519468
135CSF1R0.25357695
136MAPK100.25149909
137ROCK20.24447248

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.45598161
2T cell receptor signaling pathway_Homo sapiens_hsa046604.00999355
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.26958277
4Non-homologous end-joining_Homo sapiens_hsa034502.25297490
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.11919500
6Antigen processing and presentation_Homo sapiens_hsa046122.05246361
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01035014
8Hematopoietic cell lineage_Homo sapiens_hsa046401.75512933
9Acute myeloid leukemia_Homo sapiens_hsa052211.70780105
10B cell receptor signaling pathway_Homo sapiens_hsa046621.66076676
11Allograft rejection_Homo sapiens_hsa053301.64693250
12Measles_Homo sapiens_hsa051621.61701449
13Colorectal cancer_Homo sapiens_hsa052101.53945056
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.52075877
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41054374
16Graft-versus-host disease_Homo sapiens_hsa053321.40778448
17Thyroid cancer_Homo sapiens_hsa052161.38441050
18Chronic myeloid leukemia_Homo sapiens_hsa052201.36818358
19Endometrial cancer_Homo sapiens_hsa052131.35788286
20Long-term potentiation_Homo sapiens_hsa047201.32573090
21Osteoclast differentiation_Homo sapiens_hsa043801.31006646
22Nicotine addiction_Homo sapiens_hsa050331.29028490
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19534599
24Viral myocarditis_Homo sapiens_hsa054161.19446733
25Type I diabetes mellitus_Homo sapiens_hsa049401.18195194
26Chemokine signaling pathway_Homo sapiens_hsa040621.17756487
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16016263
28Dorso-ventral axis formation_Homo sapiens_hsa043201.15231155
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14908128
30Autoimmune thyroid disease_Homo sapiens_hsa053201.14114423
31FoxO signaling pathway_Homo sapiens_hsa040681.10076444
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09523944
33Calcium signaling pathway_Homo sapiens_hsa040201.08739704
34Hepatitis B_Homo sapiens_hsa051611.07696624
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.07554027
36HTLV-I infection_Homo sapiens_hsa051661.07076198
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06379733
38Regulation of autophagy_Homo sapiens_hsa041401.05271662
39ErbB signaling pathway_Homo sapiens_hsa040121.02940026
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02107506
41Non-small cell lung cancer_Homo sapiens_hsa052231.01759397
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.97907096
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95693335
44Pancreatic cancer_Homo sapiens_hsa052120.94593102
45Tuberculosis_Homo sapiens_hsa051520.93621243
46cAMP signaling pathway_Homo sapiens_hsa040240.93215753
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.92896349
48Asthma_Homo sapiens_hsa053100.91303211
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89086204
50Prostate cancer_Homo sapiens_hsa052150.88338689
51Prolactin signaling pathway_Homo sapiens_hsa049170.88277853
52Renal cell carcinoma_Homo sapiens_hsa052110.87888439
53Herpes simplex infection_Homo sapiens_hsa051680.83659110
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81696890
55Circadian rhythm_Homo sapiens_hsa047100.80920548
56MAPK signaling pathway_Homo sapiens_hsa040100.79874949
57GABAergic synapse_Homo sapiens_hsa047270.79701504
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79095387
59mRNA surveillance pathway_Homo sapiens_hsa030150.78615494
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78065607
61Oxytocin signaling pathway_Homo sapiens_hsa049210.76698662
62mTOR signaling pathway_Homo sapiens_hsa041500.76310025
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75540884
64VEGF signaling pathway_Homo sapiens_hsa043700.75277689
65Choline metabolism in cancer_Homo sapiens_hsa052310.74230032
66Insulin secretion_Homo sapiens_hsa049110.74138808
67Toxoplasmosis_Homo sapiens_hsa051450.73667557
68Platelet activation_Homo sapiens_hsa046110.72088888
69Phototransduction_Homo sapiens_hsa047440.71980072
70Leishmaniasis_Homo sapiens_hsa051400.71918795
71Amphetamine addiction_Homo sapiens_hsa050310.71106808
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70137502
73Wnt signaling pathway_Homo sapiens_hsa043100.69075635
74Cocaine addiction_Homo sapiens_hsa050300.68805911
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68710870
76Glioma_Homo sapiens_hsa052140.68563305
77Cholinergic synapse_Homo sapiens_hsa047250.68455292
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68377401
79Gastric acid secretion_Homo sapiens_hsa049710.67068571
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66893190
81Viral carcinogenesis_Homo sapiens_hsa052030.65479464
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64643028
83Dopaminergic synapse_Homo sapiens_hsa047280.63811396
84Hepatitis C_Homo sapiens_hsa051600.62814394
85MicroRNAs in cancer_Homo sapiens_hsa052060.61724919
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.61383480
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.61348552
88Renin secretion_Homo sapiens_hsa049240.61294206
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60854250
90Spliceosome_Homo sapiens_hsa030400.60282187
91Ras signaling pathway_Homo sapiens_hsa040140.60242656
92Serotonergic synapse_Homo sapiens_hsa047260.59928942
93Estrogen signaling pathway_Homo sapiens_hsa049150.59857593
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59632910
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59347825
96Type II diabetes mellitus_Homo sapiens_hsa049300.58427152
97Pancreatic secretion_Homo sapiens_hsa049720.58341811
98Epstein-Barr virus infection_Homo sapiens_hsa051690.57138626
99Morphine addiction_Homo sapiens_hsa050320.56530691
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56483069
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56255177
102Taste transduction_Homo sapiens_hsa047420.55942307
103RNA degradation_Homo sapiens_hsa030180.54116829
104Influenza A_Homo sapiens_hsa051640.53733873
105Inositol phosphate metabolism_Homo sapiens_hsa005620.52392159
106Glutamatergic synapse_Homo sapiens_hsa047240.52225322
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.52110003
108Salivary secretion_Homo sapiens_hsa049700.50729919
109Melanogenesis_Homo sapiens_hsa049160.50359906
110Long-term depression_Homo sapiens_hsa047300.50252765
111Endocytosis_Homo sapiens_hsa041440.50104432
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49735118
113GnRH signaling pathway_Homo sapiens_hsa049120.48813304
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47784923
115Shigellosis_Homo sapiens_hsa051310.47534155
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46902794
117Olfactory transduction_Homo sapiens_hsa047400.46825808
118TNF signaling pathway_Homo sapiens_hsa046680.46605883
119Insulin signaling pathway_Homo sapiens_hsa049100.46351088
120Adherens junction_Homo sapiens_hsa045200.45817183
121Lysine degradation_Homo sapiens_hsa003100.45745289
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45595106
123Circadian entrainment_Homo sapiens_hsa047130.45324297
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44864324
125Apoptosis_Homo sapiens_hsa042100.44596575

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