SAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cellular amide metabolic process (GO:0034250)4.95688663
2one-carbon compound transport (GO:0019755)4.89649148
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.61455757
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.61455757
5modulation by symbiont of host immune response (GO:0052553)4.61455757
6positive regulation by symbiont of host defense response (GO:0052509)4.61455757
7modulation by symbiont of host defense response (GO:0052031)4.61455757
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.61455757
9microglial cell activation (GO:0001774)4.56113072
10positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.34707770
11neutrophil activation involved in immune response (GO:0002283)4.17771922
12positive regulation of respiratory burst (GO:0060267)4.15943054
13positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.07898085
14renal absorption (GO:0070293)4.01132572
15endothelium development (GO:0003158)3.95672553
16regulation of activation of Janus kinase activity (GO:0010533)3.90061468
17detection of molecule of bacterial origin (GO:0032490)3.88503532
18regulation of cytokine secretion involved in immune response (GO:0002739)3.88331661
19positive regulation of monocyte chemotaxis (GO:0090026)3.86567674
20macrophage activation (GO:0042116)3.79024065
21positive regulation of macrophage activation (GO:0043032)3.72933494
22superoxide anion generation (GO:0042554)3.67317378
23adenine nucleotide transport (GO:0051503)3.66533712
24positive regulation of chemokine secretion (GO:0090197)3.66469980
25purine ribonucleotide transport (GO:0015868)3.66105745
26regulation of interferon-beta biosynthetic process (GO:0045357)3.63606239
27macrophage activation involved in immune response (GO:0002281)3.62211863
28response to peptidoglycan (GO:0032494)3.55056877
29regulation of respiratory burst (GO:0060263)3.54580564
30positive regulation of interferon-alpha production (GO:0032727)3.45507793
31cellular response to exogenous dsRNA (GO:0071360)3.43399836
32immunoglobulin mediated immune response (GO:0016064)3.40162341
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38757235
34negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.36121191
35regulation of heterotypic cell-cell adhesion (GO:0034114)3.34296598
36regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.30273747
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29645291
38response to host immune response (GO:0052572)3.29645291
39regulation of interleukin-8 biosynthetic process (GO:0045414)3.28417037
40phospholipid efflux (GO:0033700)3.25454311
41type I interferon signaling pathway (GO:0060337)3.23546774
42cellular response to type I interferon (GO:0071357)3.23546774
43regulation of cholesterol esterification (GO:0010872)3.23051728
44regulation of interferon-alpha production (GO:0032647)3.22552480
45response to type I interferon (GO:0034340)3.18248120
46chronic inflammatory response (GO:0002544)3.17804741
47lipoxygenase pathway (GO:0019372)3.17787383
48low-density lipoprotein particle remodeling (GO:0034374)3.16741360
49interferon-gamma-mediated signaling pathway (GO:0060333)3.15586123
50negative regulation of cytokine production involved in immune response (GO:0002719)3.12808666
51artery smooth muscle contraction (GO:0014824)3.12346187
52negative regulation of mast cell activation (GO:0033004)3.09863107
53modulation of growth of symbiont involved in interaction with host (GO:0044144)3.08417624
54regulation of growth of symbiont in host (GO:0044126)3.08417624
55negative regulation of growth of symbiont in host (GO:0044130)3.08417624
56negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.08417624
57positive regulation of mast cell activation involved in immune response (GO:0033008)3.07520652
58positive regulation of mast cell degranulation (GO:0043306)3.07520652
59leukocyte migration involved in inflammatory response (GO:0002523)3.06351287
60neutrophil activation (GO:0042119)3.06269236
61negative regulation of protein activation cascade (GO:2000258)3.05432593
62T-helper 1 type immune response (GO:0042088)3.04427690
63regulation of dendritic cell antigen processing and presentation (GO:0002604)3.02546934
64positive regulation of macrophage differentiation (GO:0045651)3.01883991
65response to interferon-beta (GO:0035456)3.00743038
66negative regulation of interleukin-12 production (GO:0032695)2.99410049
67positive regulation of antigen processing and presentation (GO:0002579)2.99317384
68purine nucleotide transport (GO:0015865)2.99168674
69regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.97704585
70Rap protein signal transduction (GO:0032486)2.97187968
71detection of external biotic stimulus (GO:0098581)2.92929306
72lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92245325
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91626153
74negative regulation of complement activation (GO:0045916)2.90150498
75negative regulation of lipid storage (GO:0010888)2.89491427
76high-density lipoprotein particle remodeling (GO:0034375)2.87636697
77ovulation from ovarian follicle (GO:0001542)2.87202211
78granulocyte activation (GO:0036230)2.86426208
79G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.85683465
80regulation of monocyte chemotaxis (GO:0090025)2.83771849
81peptide catabolic process (GO:0043171)2.82627681
82regulation of mast cell activation involved in immune response (GO:0033006)2.82313028
83positive regulation of T cell migration (GO:2000406)2.81886882
84regulation of mast cell degranulation (GO:0043304)2.81689612
85detection of biotic stimulus (GO:0009595)2.81587461
86positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.81381130
87response to muramyl dipeptide (GO:0032495)2.80902048
88positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.80312620
89production of molecular mediator involved in inflammatory response (GO:0002532)2.80309286
90gap junction assembly (GO:0016264)2.79980375
91histamine secretion (GO:0001821)2.79262274
92regulation of vitamin D biosynthetic process (GO:0060556)2.78462972
93positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.78082944
94detection of other organism (GO:0098543)2.78076630
95regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77910399
96response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77830991
97response to host (GO:0075136)2.77830991
98response to host defenses (GO:0052200)2.77830991
99positive regulation of lymphocyte migration (GO:2000403)2.73211705
100regulation of mast cell activation (GO:0033003)2.72951504
101response to protozoan (GO:0001562)2.71764787
102negative regulation of protein autophosphorylation (GO:0031953)2.70983440
103positive regulation of mast cell activation (GO:0033005)2.70906965
104tonic smooth muscle contraction (GO:0014820)2.70681099
105energy homeostasis (GO:0097009)2.70280156
106regulation of chemokine secretion (GO:0090196)2.70251774
107nucleotide transport (GO:0006862)2.70218865
108hyperosmotic salinity response (GO:0042538)2.69373002
109positive regulation of smooth muscle cell migration (GO:0014911)2.69161163
110amino acid import (GO:0043090)2.69106202
111regulation of glomerular filtration (GO:0003093)2.69101719
112phospholipid homeostasis (GO:0055091)2.69019890
113regulation of T cell chemotaxis (GO:0010819)2.68659812
114positive regulation of T cell chemotaxis (GO:0010820)2.68659812
115reverse cholesterol transport (GO:0043691)2.67877884
116atrial cardiac muscle cell action potential (GO:0086014)2.67744643
117defense response to protozoan (GO:0042832)2.67488917
118negative regulation of humoral immune response (GO:0002921)2.67405370
119skeletal muscle tissue regeneration (GO:0043403)2.67112742
120regulation of T-helper 1 cell differentiation (GO:0045625)2.66081161
121keratinocyte development (GO:0003334)2.65465472
122kidney morphogenesis (GO:0060993)2.62751548
123B cell mediated immunity (GO:0019724)2.62114320
124positive regulation of leukocyte degranulation (GO:0043302)2.61877547
125negative regulation of interleukin-1 beta production (GO:0032691)2.61652973
126cholesterol efflux (GO:0033344)2.60736675
127negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.60511014
128myeloid cell activation involved in immune response (GO:0002275)2.60041615
129regulation of RIG-I signaling pathway (GO:0039535)2.59451869
130amino sugar catabolic process (GO:0046348)2.59348482
131regulation of T-helper 1 type immune response (GO:0002825)2.58459950
132regulation of inflammatory response to antigenic stimulus (GO:0002861)2.58373842
133pinocytosis (GO:0006907)2.57969098
134opsonization (GO:0008228)2.57498505
135phagocytosis, engulfment (GO:0006911)2.55940213
136positive regulation of interferon-beta production (GO:0032728)2.55547916
137transcytosis (GO:0045056)2.55504389
138plasma lipoprotein particle assembly (GO:0034377)2.54655338
139positive regulation of toll-like receptor signaling pathway (GO:0034123)2.53781483
140phagocytosis, recognition (GO:0006910)2.52251832
141regulation of antigen processing and presentation (GO:0002577)2.52187385
142gas transport (GO:0015669)2.51396218
143Notch signaling involved in heart development (GO:0061314)2.51372991
144negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.51371584
145negative regulation of production of molecular mediator of immune response (GO:0002701)2.51231187
146regulation of interleukin-1 beta secretion (GO:0050706)2.50601597
147negative regulation of tissue remodeling (GO:0034104)2.50559982
148regulation of mononuclear cell migration (GO:0071675)2.48233051
149cytokine secretion (GO:0050663)2.47855808
150hydrogen peroxide biosynthetic process (GO:0050665)2.47801127
151myeloid leukocyte activation (GO:0002274)2.47728356
152positive regulation of chemokine production (GO:0032722)2.47436960
153adhesion of symbiont to host (GO:0044406)2.47257176
154glucuronate metabolic process (GO:0019585)2.47047491
155uronic acid metabolic process (GO:0006063)2.47047491
156positive regulation of interleukin-12 production (GO:0032735)2.45934690
157I-kappaB phosphorylation (GO:0007252)2.45876334
158response to interferon-gamma (GO:0034341)2.43776013
159cellular response to interferon-gamma (GO:0071346)2.40524048
160negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.40477850
161negative regulation of T-helper cell differentiation (GO:0045623)2.40477850
162oligosaccharide catabolic process (GO:0009313)2.40459603
163regulation of vitamin metabolic process (GO:0030656)2.39714026
164regulation of tolerance induction (GO:0002643)2.38781677
165regulation of macrophage activation (GO:0043030)2.36454588
166ER overload response (GO:0006983)2.36197520
167plasma lipoprotein particle clearance (GO:0034381)2.35490204
168positive regulation of tolerance induction (GO:0002645)2.33966616
169regulation of germinal center formation (GO:0002634)2.33866890
170positive regulation of interleukin-8 production (GO:0032757)2.33508869
171positive regulation of interleukin-6 production (GO:0032755)2.32802163
172response to interferon-alpha (GO:0035455)2.32195286
173negative regulation of viral genome replication (GO:0045071)2.31978840
174positive regulation of interleukin-1 secretion (GO:0050716)2.31569944
175regulation of interleukin-1 secretion (GO:0050704)2.31519393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.42183773
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.72407288
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.34790953
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.09039169
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.19312364
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.17590016
7* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.71048218
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.70482972
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.67268924
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62564624
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.59520634
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.57921048
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56922703
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56798285
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38414823
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28730575
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.20778378
18GATA1_22025678_ChIP-Seq_K562_Human2.19932301
19RUNX_20019798_ChIP-Seq_JUKART_Human2.17797991
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12944656
21GATA2_21666600_ChIP-Seq_HMVEC_Human2.11803271
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.10140068
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05440616
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85446099
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.78831722
26PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.70320994
27NRF2_20460467_ChIP-Seq_MEFs_Mouse1.69011737
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.69011737
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.68716733
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.65301201
31* VDR_24787735_ChIP-Seq_THP-1_Human1.61704083
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61107635
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59341734
34CJUN_26792858_Chip-Seq_BT549_Human1.53665776
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48233202
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46719786
37RXR_22108803_ChIP-Seq_LS180_Human1.46669264
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45861323
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.44771861
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43914682
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.42783357
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42224095
43* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42129839
44* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42128868
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40453203
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40161379
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37358124
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.36003667
49* GATA3_26560356_Chip-Seq_TH2_Human1.34399464
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.33457149
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28765265
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27706215
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26374056
54* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25207471
55* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25207471
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.21958974
57SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21953232
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21357475
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20797894
60SOX2_20726797_ChIP-Seq_SW620_Human1.19819533
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19609245
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19433083
63TP53_18474530_ChIP-ChIP_U2OS_Human1.19058409
64GATA4_25053715_ChIP-Seq_YYC3_Human1.15635883
65* MYB_26560356_Chip-Seq_TH2_Human1.14732880
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13436169
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12548632
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12007264
69SCL_19346495_ChIP-Seq_HPC-7_Human1.11617798
70CDX2_22108803_ChIP-Seq_LS180_Human1.11494463
71NMYC_18555785_Chip-Seq_ESCs_Mouse1.11427923
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09433032
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.09421062
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.08766634
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08739963
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08560486
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08413572
78* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08284833
79* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07375128
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06853900
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.06492035
82GBX2_23144817_ChIP-Seq_PC3_Human1.05717332
83IRF1_19129219_ChIP-ChIP_H3396_Human1.05680369
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05002421
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04697617
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.04223991
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03034950
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03030385
89CDX2_20551321_ChIP-Seq_CACO-2_Human1.02812288
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00447939
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00057152
92* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99707714
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99371941
94MYB_26560356_Chip-Seq_TH1_Human0.99354190
95PU1_27457419_Chip-Seq_LIVER_Mouse0.98544274
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98523185
97SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98134844
98JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97372000
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97314516
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97149211
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97149211
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97149211
103SPI1_23127762_ChIP-Seq_K562_Human0.97060652
104CLOCK_20551151_ChIP-Seq_293T_Human0.96955698
105NANOG_18555785_Chip-Seq_ESCs_Mouse0.96546118
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96308488
107OCT4_18555785_Chip-Seq_ESCs_Mouse0.96029962
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95478082
109* SPI1_23547873_ChIP-Seq_NB4_Human0.95270727
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.95175785
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94357178
112P300_18555785_Chip-Seq_ESCs_Mouse0.94234508
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94092332
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93851011
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93150439
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92595491
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92542128
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92396955
119SMRT_27268052_Chip-Seq_Bcells_Human0.91358109
120TP53_16413492_ChIP-PET_HCT116_Human0.91251229
121RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90957430
122GATA3_27048872_Chip-Seq_THYMUS_Human0.90236895
123ZFX_18555785_Chip-Seq_ESCs_Mouse0.90043752
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89983880
125CMYC_18555785_Chip-Seq_ESCs_Mouse0.89973539
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89864127
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89370853
128PU_27001747_Chip-Seq_BMDM_Mouse0.89026827
129P53_22387025_ChIP-Seq_ESCs_Mouse0.88595431
130SOX2_18555785_Chip-Seq_ESCs_Mouse0.88339725
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88066052
132EGR1_19374776_ChIP-ChIP_THP-1_Human0.87555643
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87251309
134* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87194833
135TP63_23658742_ChIP-Seq_EP156T_Human0.86869109
136BCAT_22108803_ChIP-Seq_LS180_Human0.86590510
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86450920
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85081691
139GATA3_24758297_ChIP-Seq_MCF-7_Human0.83496301
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.83340744
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83226869
142NANOG_19829295_ChIP-Seq_ESCs_Human0.81709255
143SOX2_19829295_ChIP-Seq_ESCs_Human0.81709255
144ER_23166858_ChIP-Seq_MCF-7_Human0.81229661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.24339086
2MP0001835_abnormal_antigen_presentation3.37148371
3MP0003690_abnormal_glial_cell3.25915963
4MP0003303_peritoneal_inflammation3.25064893
5MP0003724_increased_susceptibility_to3.09852734
6MP0002148_abnormal_hypersensitivity_rea2.97823574
7MP0005171_absent_coat_pigmentation2.92716846
8MP0001853_heart_inflammation2.70759673
9MP0000372_irregular_coat_pigmentation2.62543634
10MP0002419_abnormal_innate_immunity2.57609227
11MP0009764_decreased_sensitivity_to2.49203871
12MP0003279_aneurysm2.44037257
13MP0009785_altered_susceptibility_to2.38979417
14MP0005409_darkened_coat_color2.31190124
15MP0003075_altered_response_to2.30976712
16MP0000569_abnormal_digit_pigmentation2.17649126
17MP0003878_abnormal_ear_physiology2.16959396
18MP0005377_hearing/vestibular/ear_phenot2.16959396
19MP0002132_abnormal_respiratory_system2.12365962
20MP0005365_abnormal_bile_salt2.02651317
21MP0005000_abnormal_immune_tolerance2.00849921
22MP0003300_gastrointestinal_ulcer1.99835268
23MP0003436_decreased_susceptibility_to1.96417434
24MP0001542_abnormal_bone_strength1.94205686
25MP0002139_abnormal_hepatobiliary_system1.84354278
26MP0005058_abnormal_lysosome_morphology1.83154321
27MP0005025_abnormal_response_to1.82044212
28MP0005174_abnormal_tail_pigmentation1.81164473
29MP0001790_abnormal_immune_system1.80648131
30MP0005387_immune_system_phenotype1.80648131
31MP0002452_abnormal_antigen_presenting1.79693335
32MP0003195_calcinosis1.79605587
33MP0003828_pulmonary_edema1.77458683
34MP0008004_abnormal_stomach_pH1.76055477
35MP0002254_reproductive_system_inflammat1.74296212
36MP0003186_abnormal_redox_activity1.70294713
37MP0005671_abnormal_response_to1.70113132
38MP0003950_abnormal_plasma_membrane1.68685963
39MP0006082_CNS_inflammation1.67657582
40MP0003806_abnormal_nucleotide_metabolis1.62214356
41MP0010368_abnormal_lymphatic_system1.60575221
42MP0005166_decreased_susceptibility_to1.58017055
43MP0004782_abnormal_surfactant_physiolog1.57815997
44MP0005167_abnormal_blood-brain_barrier1.57357571
45MP0000015_abnormal_ear_pigmentation1.56799444
46MP0002723_abnormal_immune_serum1.54381507
47MP0002166_altered_tumor_susceptibility1.50238312
48MP0001819_abnormal_immune_cell1.50037993
49MP0002420_abnormal_adaptive_immunity1.48585318
50MP0000343_altered_response_to1.47363663
51MP0005451_abnormal_body_composition1.46584447
52MP0001800_abnormal_humoral_immune1.46405682
53MP0006054_spinal_hemorrhage1.45685022
54MP0009697_abnormal_copulation1.45519696
55MP0004883_abnormal_blood_vessel1.42731722
56MP0008260_abnormal_autophagy1.40256478
57MP0005464_abnormal_platelet_physiology1.38701801
58MP0001879_abnormal_lymphatic_vessel1.37831166
59MP0002998_abnormal_bone_remodeling1.35458818
60MP0000371_diluted_coat_color1.35251479
61MP0009384_cardiac_valve_regurgitation1.31474799
62MP0003191_abnormal_cellular_cholesterol1.31063999
63MP0002138_abnormal_hepatobiliary_system1.30939352
64MP0002277_abnormal_respiratory_mucosa1.30667436
65MP0003172_abnormal_lysosome_physiology1.29904865
66MP0005164_abnormal_response_to1.28745900
67MP0002405_respiratory_system_inflammati1.28248869
68MP0010155_abnormal_intestine_physiology1.23177633
69MP0003448_altered_tumor_morphology1.22870710
70MP0001533_abnormal_skeleton_physiology1.22020906
71MP0001845_abnormal_inflammatory_respons1.21990257
72MP0001986_abnormal_taste_sensitivity1.21103623
73MP0000566_synostosis1.20371389
74MP0008438_abnormal_cutaneous_collagen1.19386212
75MP0000685_abnormal_immune_system1.18186458
76MP0008007_abnormal_cellular_replicative1.16409675
77MP0000465_gastrointestinal_hemorrhage1.16147759
78MP0009840_abnormal_foam_cell1.15863121
79MP0008469_abnormal_protein_level1.12947543
80MP0004264_abnormal_extraembryonic_tissu1.10419269
81MP0000767_abnormal_smooth_muscle1.08585947
82MP0004947_skin_inflammation1.08584058
83MP0005084_abnormal_gallbladder_morpholo1.04476834
84MP0008875_abnormal_xenobiotic_pharmacok1.04156334
85MP0003656_abnormal_erythrocyte_physiolo1.04081282
86MP0005646_abnormal_pituitary_gland1.02926772
87MP0009278_abnormal_bone_marrow1.01862061
88MP0000604_amyloidosis1.00723778
89MP0002009_preneoplasia0.99638222
90MP0004381_abnormal_hair_follicle0.99205940
91MP0002396_abnormal_hematopoietic_system0.94545501
92MP0001958_emphysema0.94184527
93MP0005390_skeleton_phenotype0.91891563
94MP0005410_abnormal_fertilization0.90672861
95MP0005165_increased_susceptibility_to0.90665455
96MP0009333_abnormal_splenocyte_physiolog0.88396644
97MP0003718_maternal_effect0.85584057
98MP0003941_abnormal_skin_development0.85474005
99MP0000716_abnormal_immune_system0.85092311
100MP0009643_abnormal_urine_homeostasis0.84488389
101MP0001915_intracranial_hemorrhage0.84297901
102MP0001881_abnormal_mammary_gland0.84027527
103MP0000249_abnormal_blood_vessel0.83625360
104MP0001851_eye_inflammation0.82570111
105MP0002295_abnormal_pulmonary_circulatio0.81947511
106MP0001666_abnormal_nutrient_absorption0.81733385
107MP0004510_myositis0.80458736
108MP0010329_abnormal_lipoprotein_level0.80458679
109MP0003183_abnormal_peptide_metabolism0.79002622
110MP0002136_abnormal_kidney_physiology0.78648599
111MP0005085_abnormal_gallbladder_physiolo0.78442878
112MP0005023_abnormal_wound_healing0.78263088
113MP0005408_hypopigmentation0.77993038
114MP0002089_abnormal_postnatal_growth/wei0.77212931
115MP0005310_abnormal_salivary_gland0.76640984
116MP0003943_abnormal_hepatobiliary_system0.76244225
117MP0002098_abnormal_vibrissa_morphology0.75472518
118* MP0000609_abnormal_liver_physiology0.73976285
119MP0003866_abnormal_defecation0.72536223
120MP0002398_abnormal_bone_marrow0.71833746
121MP0000689_abnormal_spleen_morphology0.71181299
122MP0009763_increased_sensitivity_to0.70348524
123MP0002006_tumorigenesis0.70316772
124MP0005397_hematopoietic_system_phenotyp0.69398124
125MP0001545_abnormal_hematopoietic_system0.69398124
126MP0002877_abnormal_melanocyte_morpholog0.68213225
127MP0004019_abnormal_vitamin_homeostasis0.67310239
128MP0000627_abnormal_mammary_gland0.65929367
129MP0002876_abnormal_thyroid_physiology0.65829247
130MP0003045_fibrosis0.65723538
131MP0000858_altered_metastatic_potential0.65473184

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.53887035
2Aplasia involving bones of the upper limbs (HP:0009823)4.37084343
3Aplasia of the phalanges of the hand (HP:0009802)4.37084343
4Aplasia involving bones of the extremities (HP:0009825)4.37084343
5Eczematoid dermatitis (HP:0000976)4.28957594
6Recurrent bacterial skin infections (HP:0005406)4.27315037
7Amyloidosis (HP:0011034)4.02320691
8Short middle phalanx of the 5th finger (HP:0004220)3.79510240
9Abnormality of the axillary hair (HP:0100134)3.79162193
10Abnormality of secondary sexual hair (HP:0009888)3.79162193
11Dry hair (HP:0011359)3.78889091
12Tetraparesis (HP:0002273)3.66918368
13White forelock (HP:0002211)3.54120300
14Albinism (HP:0001022)3.47241551
15Patchy hypopigmentation of hair (HP:0011365)3.46885328
16Systemic lupus erythematosus (HP:0002725)3.46811472
17Elevated erythrocyte sedimentation rate (HP:0003565)3.43360733
18Prostate neoplasm (HP:0100787)3.36000331
19Retrobulbar optic neuritis (HP:0100654)3.24749892
20Optic neuritis (HP:0100653)3.24749892
21Abnormality of macrophages (HP:0004311)3.16603185
22Gingival bleeding (HP:0000225)3.15616204
23Recurrent gram-negative bacterial infections (HP:0005420)3.15197009
24Petechiae (HP:0000967)3.13780383
25Basal ganglia calcification (HP:0002135)3.08894038
26Orchitis (HP:0100796)3.08109031
27Hypoplastic left heart (HP:0004383)3.06239220
28Thick nail (HP:0001805)3.05452077
29Autoimmune hemolytic anemia (HP:0001890)3.03723979
30Congenital sensorineural hearing impairment (HP:0008527)3.02859181
31Spontaneous abortion (HP:0005268)3.00311027
32Mediastinal lymphadenopathy (HP:0100721)2.99622387
33Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.98364061
34Myositis (HP:0100614)2.83293372
35Vacuolated lymphocytes (HP:0001922)2.78601141
36Joint swelling (HP:0001386)2.76686337
37Abnormality of the columella (HP:0009929)2.75541834
38Pustule (HP:0200039)2.72230233
39Increased CSF protein (HP:0002922)2.71728505
40Long nose (HP:0003189)2.71677674
41Aplasia/Hypoplasia of the fovea (HP:0008060)2.71578581
42Hypoplasia of the fovea (HP:0007750)2.71578581
43Glomerulonephritis (HP:0000099)2.70596901
44Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.68816597
45Loss of speech (HP:0002371)2.65526156
46Axonal loss (HP:0003447)2.63738354
47Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.59294206
48Premature loss of primary teeth (HP:0006323)2.58742068
49Prolonged neonatal jaundice (HP:0006579)2.55965407
50Gingivitis (HP:0000230)2.54680658
51Gastrointestinal infarctions (HP:0005244)2.53859730
52Hypoplastic heart (HP:0001961)2.52249058
53Malnutrition (HP:0004395)2.52005825
54Hemoptysis (HP:0002105)2.51721357
55Neoplasm of the tracheobronchial system (HP:0100552)2.51551398
56Recurrent skin infections (HP:0001581)2.49811495
57Complement deficiency (HP:0004431)2.43704891
58Steatorrhea (HP:0002570)2.43228543
59Recurrent pneumonia (HP:0006532)2.39066840
60Abnormality of the phalanges of the 5th finger (HP:0004213)2.36758512
61Abnormality of molar (HP:0011077)2.35788579
62Abnormality of molar morphology (HP:0011070)2.35788579
63Autoimmune thrombocytopenia (HP:0001973)2.34318667
64Gangrene (HP:0100758)2.32576043
65Abnormality of permanent molar morphology (HP:0011071)2.32094466
66Abnormality of the dental root (HP:0006486)2.32094466
67Taurodontia (HP:0000679)2.32094466
68Stomach cancer (HP:0012126)2.31733357
69Abnormality of glycolipid metabolism (HP:0010969)2.29628630
70Abnormality of liposaccharide metabolism (HP:0010968)2.29628630
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.29628630
72Polyneuropathy (HP:0001271)2.28869859
73Abnormality of the fovea (HP:0000493)2.27664697
74Short hallux (HP:0010109)2.26190495
75Fat malabsorption (HP:0002630)2.25725697
76Onycholysis (HP:0001806)2.25092972
77Abnormality of the common coagulation pathway (HP:0010990)2.24505408
78Increased serum ferritin (HP:0003281)2.21900293
79Dysostosis multiplex (HP:0000943)2.21012482
80Abnormality of transition element cation homeostasis (HP:0011030)2.18453223
81Generalized hypopigmentation (HP:0007513)2.18184237
82Epistaxis (HP:0000421)2.17656264
83Abnormality of iron homeostasis (HP:0011031)2.16874318
84Increased neuronal autofluorescent lipopigment (HP:0002074)2.16207415
85Nephritis (HP:0000123)2.15752460
86Short nail (HP:0001799)2.14114336
87Abnormality of the dental pulp (HP:0006479)2.11272774
88Osteolytic defects of the hand bones (HP:0009699)2.09277469
89Osteolytic defects of the phalanges of the hand (HP:0009771)2.09277469
90Hypobetalipoproteinemia (HP:0003563)2.09137814
91Increased IgM level (HP:0003496)2.08545921
92Purpura (HP:0000979)2.07444487
93Chronic obstructive pulmonary disease (HP:0006510)2.06664870
94Obstructive lung disease (HP:0006536)2.06664870
95Abnormality of polysaccharide metabolism (HP:0011012)2.05539086
96Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05539086
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05539086
98Mixed hearing impairment (HP:0000410)2.05138689
99Myocardial infarction (HP:0001658)2.04297569
100Stomatitis (HP:0010280)2.03730275
101Vasculitis (HP:0002633)2.02076644
102Tongue fasciculations (HP:0001308)2.01561484
103Recurrent fungal infections (HP:0002841)2.01245475
104Congenital, generalized hypertrichosis (HP:0004540)2.00592880
105Intrahepatic cholestasis (HP:0001406)2.00523456
106Keratoconjunctivitis sicca (HP:0001097)2.00491849
107Thrombophlebitis (HP:0004418)1.99462736
108Anorexia (HP:0002039)1.99447380
109Aplasia/Hypoplasia of the hallux (HP:0008362)1.99109736
110Paraparesis (HP:0002385)1.98881228
111Diaphragmatic weakness (HP:0009113)1.98744686
112Selective tooth agenesis (HP:0001592)1.98597368
113Disinhibition (HP:0000734)1.98434631
114Abnormality of the vasculature of the conjunctiva (HP:0008054)1.98399662
115Craniofacial hyperostosis (HP:0004493)1.98170045
116Abnormality of complement system (HP:0005339)1.97899184
117Pulmonary embolism (HP:0002204)1.97822544
118Muscle fibrillation (HP:0010546)1.97016329
119Renal tubular acidosis (HP:0001947)1.95773739
120Prolonged bleeding time (HP:0003010)1.95309258
121Chronic diarrhea (HP:0002028)1.95107724
122Pulmonary infiltrates (HP:0002113)1.93155456
123Recurrent lower respiratory tract infections (HP:0002783)1.92620956
124Mucopolysacchariduria (HP:0008155)1.90205409
125Urinary glycosaminoglycan excretion (HP:0003541)1.90205409
126Eosinophilia (HP:0001880)1.88785391
127Hepatosplenomegaly (HP:0001433)1.87922721
128Keratoconjunctivitis (HP:0001096)1.87792628
129Poor head control (HP:0002421)1.87478273
130Concave nail (HP:0001598)1.87440338
131Bilateral sensorineural hearing impairment (HP:0008619)1.87096950
132Increased cerebral lipofuscin (HP:0011813)1.85772360
133Symptomatic seizures (HP:0011145)1.85647461
134Episodic fever (HP:0001954)1.85321109
135Alveolar cell carcinoma (HP:0006519)1.85294538
136Arterial thrombosis (HP:0004420)1.84141210
137Pulmonary artery stenosis (HP:0004415)1.82596547
138Pancreatic islet-cell hyperplasia (HP:0004510)1.82357748
139Abnormality of the prostate (HP:0008775)1.82060447
140Periodontitis (HP:0000704)1.82049856
141Glomerulopathy (HP:0100820)1.81258468
142Hypolipoproteinemia (HP:0010981)1.80524555
143Parakeratosis (HP:0001036)1.79801130
144Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79328901
145Generalized hypopigmentation of hair (HP:0011358)1.78361403
146Recurrent sinusitis (HP:0011108)1.78190477
147Vascular calcification (HP:0004934)1.77681419
148Hypoglycemic seizures (HP:0002173)1.77634597
149Recurrent cutaneous fungal infections (HP:0011370)1.76752096
150Chronic mucocutaneous candidiasis (HP:0002728)1.76752096
151Median cleft lip (HP:0000161)1.73919956
152Cranial hyperostosis (HP:0004437)1.73449549
153Nausea (HP:0002018)1.73173040
154Abnormality of primary teeth (HP:0006481)1.73076584
155Segmental peripheral demyelination/remyelination (HP:0003481)1.73048321
156Cheilitis (HP:0100825)1.73039386
157Meningitis (HP:0001287)1.72947500
158Abnormality of the renal collecting system (HP:0004742)1.72767688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK26.69158001
2TNIK5.75418092
3MKNK14.04376517
4IRAK34.04237042
5MAP3K143.36480312
6IRAK42.50452084
7NEK62.25560452
8FER2.17753891
9BRSK22.13114363
10SIK32.11810627
11TGFBR22.11810546
12LMTK21.91035884
13IKBKB1.82831786
14PDK21.80638415
15MUSK1.78848732
16TXK1.75461958
17STK161.74794022
18GRK71.74555353
19TAOK31.67554720
20MST41.67455946
21MAPK71.64187454
22TIE11.58706282
23ZAK1.52040220
24PIM21.47221238
25ACVR1B1.39705595
26FRK1.39645079
27TYK21.39394838
28IKBKE1.32529040
29EPHA21.31960805
30MAPK121.29422841
31TEC1.25017247
32TRIM281.24545537
33PBK1.22372050
34TBK11.21296066
35STK101.20175091
36MAP3K21.19198803
37STK38L1.18565863
38NLK1.17463141
39PIK3CA1.16677631
40STK241.15520090
41DDR21.15052430
42MAP3K31.13173297
43EIF2AK21.12359652
44OXSR11.12263687
45NEK91.12102465
46MATK1.11714988
47BMPR21.11417182
48CHUK1.10951457
49TRPM71.06094596
50RIPK41.03581206
51WEE10.99184911
52STK390.98576967
53ADRBK20.93422733
54NUAK10.93258525
55ABL20.92405035
56ERBB30.92100183
57BMPR1B0.91597574
58RIPK10.90053613
59MAP4K10.89959459
60MAP3K130.88809018
61PAK30.87106122
62PINK10.85879794
63EIF2AK30.84503087
64BLK0.84442821
65NME20.83279041
66JAK30.82566006
67EPHA30.80282383
68JAK20.79371255
69PIK3CG0.78892676
70LYN0.78843477
71JAK10.74011055
72FES0.72894262
73PIM10.72810037
74FGR0.72337339
75PRKCI0.68838020
76CSF1R0.66897871
77AKT30.64844906
78PRKCE0.63459950
79GRK10.63401667
80CLK10.63148155
81KIT0.62976373
82CDK30.59723772
83INSRR0.59116250
84MAP4K20.56803563
85IGF1R0.54979662
86TNK20.54961741
87PRKCQ0.54347355
88MAPK150.53258638
89MAP3K120.51867147
90STK30.51639133
91SGK20.49871593
92MAPKAPK50.49678992
93PRKG20.48661505
94PTK2B0.46950651
95LRRK20.46147938
96BTK0.45836601
97MAPKAPK30.45729289
98ITK0.45424747
99BCR0.44673135
100HCK0.43801573
101IRAK20.42884890
102MAP2K20.42577616
103CDK60.42046167
104SGK30.41751788
105MOS0.41562189
106ABL10.41398886
107SYK0.40835946
108PRKCD0.40608253
109EGFR0.40553401
110MAP2K70.39776861
111PRKCG0.39223264
112MAP3K50.39144554
113ZAP700.38696011
114YES10.37673085
115CDC42BPA0.37389450
116CASK0.36838364
117PDK10.36423232
118MST1R0.34561577
119BRSK10.34066567
120ROCK10.34050994
121GSK3A0.33346053
122MAP3K110.32306262
123IRAK10.31947185
124PDPK10.31772104
125CSK0.31650694
126MAPK40.31225078
127MAP2K30.31167285
128MAPKAPK20.29625809
129PRPF4B0.27817191
130MARK30.27194260
131LCK0.26661041
132TAOK20.25343970
133PLK20.24841685
134ERN10.23292520
135STK40.23234555
136EPHB10.22389924
137MAP3K10.22104316
138PRKCA0.21438453
139FGFR30.20308301

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.70238975
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.68108241
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.32873736
4Graft-versus-host disease_Homo sapiens_hsa053322.24633221
5Malaria_Homo sapiens_hsa051442.20661862
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.08079191
7Lysosome_Homo sapiens_hsa041422.06695048
8Rheumatoid arthritis_Homo sapiens_hsa053232.05750365
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.04876152
10Allograft rejection_Homo sapiens_hsa053302.04416944
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99545001
12Leishmaniasis_Homo sapiens_hsa051401.99425030
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99397908
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96760570
15Vitamin digestion and absorption_Homo sapiens_hsa049771.94416764
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.91766585
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.86454809
18Autoimmune thyroid disease_Homo sapiens_hsa053201.86453911
19African trypanosomiasis_Homo sapiens_hsa051431.83087299
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.80685742
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75343418
22Legionellosis_Homo sapiens_hsa051341.70230541
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.67149252
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.66175076
25Other glycan degradation_Homo sapiens_hsa005111.66016467
26Steroid biosynthesis_Homo sapiens_hsa001001.65130471
27Measles_Homo sapiens_hsa051621.52192174
28Tuberculosis_Homo sapiens_hsa051521.47534002
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47446646
30Pertussis_Homo sapiens_hsa051331.45575833
31Hematopoietic cell lineage_Homo sapiens_hsa046401.45024695
32Phagosome_Homo sapiens_hsa041451.43176823
33Influenza A_Homo sapiens_hsa051641.41206136
34Osteoclast differentiation_Homo sapiens_hsa043801.38199060
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37978819
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36183092
37Mineral absorption_Homo sapiens_hsa049781.33294606
38Arachidonic acid metabolism_Homo sapiens_hsa005901.33278271
39TNF signaling pathway_Homo sapiens_hsa046681.30144480
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20146019
41Chemical carcinogenesis_Homo sapiens_hsa052041.20119644
42Herpes simplex infection_Homo sapiens_hsa051681.17376930
43Apoptosis_Homo sapiens_hsa042101.14765605
44Complement and coagulation cascades_Homo sapiens_hsa046101.11743112
45Collecting duct acid secretion_Homo sapiens_hsa049661.10704497
46Sphingolipid metabolism_Homo sapiens_hsa006001.09628900
47Regulation of autophagy_Homo sapiens_hsa041401.08140066
48Caffeine metabolism_Homo sapiens_hsa002321.07998751
49Fat digestion and absorption_Homo sapiens_hsa049751.07199661
50Circadian rhythm_Homo sapiens_hsa047101.05264597
51Asthma_Homo sapiens_hsa053101.05147676
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.03017332
53Vitamin B6 metabolism_Homo sapiens_hsa007500.99529794
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.99246404
55Toxoplasmosis_Homo sapiens_hsa051450.98038203
56Proteasome_Homo sapiens_hsa030500.96884470
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96407036
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96144475
59Ether lipid metabolism_Homo sapiens_hsa005650.96137331
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94290102
61Nitrogen metabolism_Homo sapiens_hsa009100.93671974
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90265200
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.88413835
64Dorso-ventral axis formation_Homo sapiens_hsa043200.87503789
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85375075
66Primary immunodeficiency_Homo sapiens_hsa053400.85201088
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85189615
68Folate biosynthesis_Homo sapiens_hsa007900.83797634
69Salmonella infection_Homo sapiens_hsa051320.83509206
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81550053
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79584418
72Hepatitis C_Homo sapiens_hsa051600.79056970
73Retinol metabolism_Homo sapiens_hsa008300.76885107
74Type I diabetes mellitus_Homo sapiens_hsa049400.73481689
75Antigen processing and presentation_Homo sapiens_hsa046120.71672732
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71539745
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71173300
78Starch and sucrose metabolism_Homo sapiens_hsa005000.69256302
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68751879
80Peroxisome_Homo sapiens_hsa041460.64707634
81Shigellosis_Homo sapiens_hsa051310.63537447
82Histidine metabolism_Homo sapiens_hsa003400.63388295
83Hepatitis B_Homo sapiens_hsa051610.62740633
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.62665899
85Glutathione metabolism_Homo sapiens_hsa004800.61909317
86T cell receptor signaling pathway_Homo sapiens_hsa046600.58917379
87Chemokine signaling pathway_Homo sapiens_hsa040620.58841617
88PPAR signaling pathway_Homo sapiens_hsa033200.58443412
89Viral myocarditis_Homo sapiens_hsa054160.57467640
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57419840
91p53 signaling pathway_Homo sapiens_hsa041150.56098680
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55974121
93Linoleic acid metabolism_Homo sapiens_hsa005910.54394252
94Prion diseases_Homo sapiens_hsa050200.54387062
95Small cell lung cancer_Homo sapiens_hsa052220.54180189
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54171891
97Tryptophan metabolism_Homo sapiens_hsa003800.53529078
98B cell receptor signaling pathway_Homo sapiens_hsa046620.50850773
99beta-Alanine metabolism_Homo sapiens_hsa004100.49592782
100Galactose metabolism_Homo sapiens_hsa000520.47195055
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47191692
102TGF-beta signaling pathway_Homo sapiens_hsa043500.46311064
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.45997593
104Vibrio cholerae infection_Homo sapiens_hsa051100.45026702
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44629568
106ECM-receptor interaction_Homo sapiens_hsa045120.43978013
107Fatty acid biosynthesis_Homo sapiens_hsa000610.43255559
108Amoebiasis_Homo sapiens_hsa051460.41220255
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41101019
110Insulin resistance_Homo sapiens_hsa049310.40871519
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40156614
112ABC transporters_Homo sapiens_hsa020100.39257603
113Sulfur metabolism_Homo sapiens_hsa009200.38968640
114Tyrosine metabolism_Homo sapiens_hsa003500.38774571
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37377257
116Glycerolipid metabolism_Homo sapiens_hsa005610.37145241
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36175790
118HIF-1 signaling pathway_Homo sapiens_hsa040660.35096789
119Protein export_Homo sapiens_hsa030600.34797057
120Renin-angiotensin system_Homo sapiens_hsa046140.34653938
121Platelet activation_Homo sapiens_hsa046110.32974210
122FoxO signaling pathway_Homo sapiens_hsa040680.32598094
123Fatty acid degradation_Homo sapiens_hsa000710.28665769

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