SASH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a scaffold protein involved in the TLR4 signaling pathway that may stimulate cytokine production and endothelial cell migration in response to invading pathogens. The encoded protein has also been described as a potential tumor suppressor that may negatively regulate proliferation, apoptosis, and invasion of cancer cells, and reduced expression of this gene has been observed in multiple human cancers. Mutations in this gene may be associated with abnormal skin pigmentation in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1apoptotic cell clearance (GO:0043277)3.61809550
2cell adhesion mediated by integrin (GO:0033627)3.51869470
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.45243454
4positive regulation by organism of defense response of other organism involved in symbiotic interact3.45243454
5modulation by symbiont of host immune response (GO:0052553)3.45243454
6positive regulation by symbiont of host defense response (GO:0052509)3.45243454
7modulation by symbiont of host defense response (GO:0052031)3.45243454
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.45243454
9chondrocyte proliferation (GO:0035988)3.44304188
10lymphangiogenesis (GO:0001946)3.35025426
11low-density lipoprotein particle clearance (GO:0034383)3.27896662
12blood vessel maturation (GO:0001955)3.18143266
13regulation of cholesterol storage (GO:0010885)3.13087848
14positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.09423684
15cell migration involved in heart development (GO:0060973)2.96870947
16endothelium development (GO:0003158)2.96860677
17extracellular matrix assembly (GO:0085029)2.93908368
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.88844517
19positive regulation of macrophage cytokine production (GO:0060907)2.86796329
20protein localization to endosome (GO:0036010)2.86026704
21L-amino acid import (GO:0043092)2.79809903
22regulation of membrane protein ectodomain proteolysis (GO:0051043)2.77887584
23cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.74160115
24axon extension involved in axon guidance (GO:0048846)2.74002839
25neuron projection extension involved in neuron projection guidance (GO:1902284)2.74002839
26skin morphogenesis (GO:0043589)2.69961649
27dermatan sulfate metabolic process (GO:0030205)2.68346984
28artery development (GO:0060840)2.64756956
29macrophage activation involved in immune response (GO:0002281)2.64363348
30regulation of axon extension involved in axon guidance (GO:0048841)2.62476782
31alanine transport (GO:0032328)2.60082773
32regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.59478206
33metanephric mesenchyme development (GO:0072075)2.58896904
34barbed-end actin filament capping (GO:0051016)2.56903345
35lipoprotein transport (GO:0042953)2.56595933
36regulation of integrin-mediated signaling pathway (GO:2001044)2.55572943
37synaptic vesicle docking involved in exocytosis (GO:0016081)2.55132251
38positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.54105012
39kidney mesenchyme development (GO:0072074)2.53781359
40negative regulation of vascular permeability (GO:0043116)2.52020466
41paraxial mesoderm development (GO:0048339)2.51931961
42sodium ion export (GO:0071436)2.51114441
43plasma lipoprotein particle clearance (GO:0034381)2.50075932
44regulation of interferon-beta biosynthetic process (GO:0045357)2.49577161
45semaphorin-plexin signaling pathway (GO:0071526)2.49481904
46vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.48862286
47cell communication by electrical coupling (GO:0010644)2.45599403
48stress fiber assembly (GO:0043149)2.45193454
49vascular endothelial growth factor signaling pathway (GO:0038084)2.45008183
50regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.44771378
51negative regulation of smooth muscle cell migration (GO:0014912)2.42779023
52extracellular fibril organization (GO:0043206)2.42720955
53regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.41957180
54peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.41059378
55basement membrane organization (GO:0071711)2.40571585
56substrate adhesion-dependent cell spreading (GO:0034446)2.40305882
57amino acid import (GO:0043090)2.40293888
58protein heterotrimerization (GO:0070208)2.38584396
59alpha-linolenic acid metabolic process (GO:0036109)2.38213713
60negative regulation of protein localization to cell surface (GO:2000009)2.36853102
61adherens junction assembly (GO:0034333)2.36664749
62glomerular basement membrane development (GO:0032836)2.36097224
63positive regulation of fatty acid beta-oxidation (GO:0032000)2.35465753
64wound healing, spreading of epidermal cells (GO:0035313)2.34970875
65macroautophagy (GO:0016236)2.34840277
66retina vasculature morphogenesis in camera-type eye (GO:0061299)2.34295167
67smooth muscle tissue development (GO:0048745)2.33311566
68regulation of axon guidance (GO:1902667)2.33183904
69Notch signaling involved in heart development (GO:0061314)2.33136049
70lymph vessel development (GO:0001945)2.32996963
71negative regulation of chondrocyte differentiation (GO:0032331)2.32646267
72hippo signaling (GO:0035329)2.32353592
73regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.30238838
74phospholipid homeostasis (GO:0055091)2.29864754
75endodermal cell differentiation (GO:0035987)2.28106177
76cytoskeletal anchoring at plasma membrane (GO:0007016)2.27912831
77endocrine hormone secretion (GO:0060986)2.26004921
78regulation of macrophage cytokine production (GO:0010935)2.25990960
79cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.25385203
80negative regulation of fatty acid transport (GO:2000192)2.25377178
81cell proliferation involved in metanephros development (GO:0072203)2.25136786
82sequestering of extracellular ligand from receptor (GO:0035581)2.24928381
83regulation of clathrin-mediated endocytosis (GO:2000369)2.24739608
84adhesion of symbiont to host cell (GO:0044650)2.24479804
85virion attachment to host cell (GO:0019062)2.24479804
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.24360114
87cGMP-mediated signaling (GO:0019934)2.24084610
88neuron remodeling (GO:0016322)2.24006757
89positive regulation of receptor recycling (GO:0001921)2.23605446
90triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.22827396
91I-kappaB phosphorylation (GO:0007252)2.22800348
92cellular potassium ion homeostasis (GO:0030007)2.20442398
93endocardial cushion development (GO:0003197)2.19924432
94axon ensheathment in central nervous system (GO:0032291)2.19834545
95central nervous system myelination (GO:0022010)2.19834545
96regulation of macrophage chemotaxis (GO:0010758)2.19584210
97plasma membrane repair (GO:0001778)2.19384270
98focal adhesion assembly (GO:0048041)2.19246768
99cell-substrate adherens junction assembly (GO:0007045)2.19246768
100peptide cross-linking (GO:0018149)2.19128785
101axon extension (GO:0048675)2.18997103
102desmosome organization (GO:0002934)2.17942510
103glomerular visceral epithelial cell development (GO:0072015)2.17423575
104keratinization (GO:0031424)2.16485858
105cellular response to cholesterol (GO:0071397)2.16415804
106regulation of chemokine-mediated signaling pathway (GO:0070099)2.14551534
107regulation of glomerular filtration (GO:0003093)2.13201543
108renal filtration (GO:0097205)2.13155357
109chondroitin sulfate catabolic process (GO:0030207)2.11305195
110keratan sulfate catabolic process (GO:0042340)2.11280150
111dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.10773258
112platelet-derived growth factor receptor signaling pathway (GO:0048008)2.10460568
113astrocyte development (GO:0014002)2.10290750
114response to lipoprotein particle (GO:0055094)2.10235113
115chondrocyte development (GO:0002063)2.10211922
116substrate-dependent cell migration (GO:0006929)2.10180677
117extracellular matrix organization (GO:0030198)2.09869892
118negative regulation of catenin import into nucleus (GO:0035414)2.09750688
119negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.09620030
120insulin-like growth factor receptor signaling pathway (GO:0048009)2.09335835
121adhesion of symbiont to host (GO:0044406)2.09129899
122extracellular structure organization (GO:0043062)2.08962596
123positive regulation of fibroblast migration (GO:0010763)2.08831592
124positive regulation of endothelial cell apoptotic process (GO:2000353)2.08407101
125protein localization to cell surface (GO:0034394)2.08150182
126response to host immune response (GO:0052572)2.07075251
127response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.07075251
128collagen metabolic process (GO:0032963)2.06549751
129cortical actin cytoskeleton organization (GO:0030866)2.06017980
130import into cell (GO:0098657)2.04075837
131multicellular organismal macromolecule metabolic process (GO:0044259)2.03968888
132locomotory exploration behavior (GO:0035641)2.03965821
133collagen catabolic process (GO:0030574)2.03905390
134dicarboxylic acid biosynthetic process (GO:0043650)2.02574094
135positive regulation of fatty acid oxidation (GO:0046321)2.02057900
136dermatan sulfate biosynthetic process (GO:0030208)2.01907342
137positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.01320820
138glomerular filtration (GO:0003094)2.01200907
139response to fluid shear stress (GO:0034405)2.00766641
140regulation of mononuclear cell migration (GO:0071675)2.00739729
141collagen fibril organization (GO:0030199)2.00642728
142regulation of sequestering of triglyceride (GO:0010889)2.00347537
143regulation of macrophage derived foam cell differentiation (GO:0010743)1.99779949
144endothelial cell morphogenesis (GO:0001886)1.99454412
145regulation of cholesterol homeostasis (GO:2000188)1.99411254
146positive regulation of cholesterol efflux (GO:0010875)1.96793741
147growth hormone receptor signaling pathway (GO:0060396)1.96732949
148positive regulation of lipid catabolic process (GO:0050996)1.96570166
149positive regulation of lipid storage (GO:0010884)1.96482651
150regulation of fatty acid beta-oxidation (GO:0031998)1.96130510
151glomerular epithelial cell development (GO:0072310)1.96087938
152cell migration involved in sprouting angiogenesis (GO:0002042)1.95358445
153regulation of integrin activation (GO:0033623)1.95355925
154heparan sulfate proteoglycan biosynthetic process (GO:0015012)1.95044406
155response to defenses of other organism involved in symbiotic interaction (GO:0052173)1.95022329
156response to host (GO:0075136)1.95022329
157response to host defenses (GO:0052200)1.95022329
158positive regulation of cellular amide metabolic process (GO:0034250)1.94491285
159negative regulation of lipid storage (GO:0010888)1.94244289
160potassium ion import (GO:0010107)1.94079943
161cell-substrate junction assembly (GO:0007044)1.93752366
162multicellular organismal metabolic process (GO:0044236)1.93695165
163modification by symbiont of host morphology or physiology (GO:0044003)1.93122351
164complement activation, alternative pathway (GO:0006957)1.92477508
165hemidesmosome assembly (GO:0031581)1.92295798
166peripheral nervous system axon ensheathment (GO:0032292)1.91722601
167myelination in peripheral nervous system (GO:0022011)1.91722601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human2.92388792
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.47007855
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25771356
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.14598512
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.91502721
6* LXR_22158963_ChIP-Seq_LIVER_Mouse1.90758835
7* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87328572
8CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83917079
9* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.81919647
10RXR_22158963_ChIP-Seq_LIVER_Mouse1.78854075
11* ESR2_21235772_ChIP-Seq_MCF-7_Human1.73994747
12RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70509910
13GBX2_23144817_ChIP-Seq_PC3_Human1.69642783
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65605195
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.61319972
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59028737
17WT1_19549856_ChIP-ChIP_CCG9911_Human1.57221830
18* CLOCK_20551151_ChIP-Seq_293T_Human1.56000954
19DROSHA_22980978_ChIP-Seq_HELA_Human1.47789992
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46156268
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.46038681
22BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44012357
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43735976
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.43673692
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43672751
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.42644979
27* FOXO3_23340844_ChIP-Seq_DLD1_Human1.39996810
28TP53_16413492_ChIP-PET_HCT116_Human1.38965972
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38910559
30* BRD4_25478319_ChIP-Seq_HGPS_Human1.38413140
31* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.38055796
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36385364
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36210693
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35595778
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35595778
36* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33709868
37* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33709868
38KDM2B_26808549_Chip-Seq_K562_Human1.33032319
39AHR_22903824_ChIP-Seq_MCF-7_Human1.32366709
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32184014
41* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31162397
42* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30181571
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29376606
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28431253
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27595988
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27576030
47* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27121145
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.26579932
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25944483
50CJUN_26792858_Chip-Seq_BT549_Human1.25564443
51PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.25521044
52* EP300_21415370_ChIP-Seq_HL-1_Mouse1.25398004
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25124780
54* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23928079
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23652841
56EZH2_22144423_ChIP-Seq_EOC_Human1.23399606
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21886249
58AR_21572438_ChIP-Seq_LNCaP_Human1.21626763
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.21519207
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.21297806
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21228307
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.19670696
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19397987
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18935267
65* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18153308
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17226004
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16878549
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16574890
69* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16402675
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16301586
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16060778
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.15991522
73* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15821468
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.14070018
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13636501
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13144295
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.12705577
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.12274444
79* RXR_22108803_ChIP-Seq_LS180_Human1.12239036
80VDR_24787735_ChIP-Seq_THP-1_Human1.11724432
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11347694
82* SMAD4_21799915_ChIP-Seq_A2780_Human1.10146549
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10044700
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.08715980
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07714631
86* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06815671
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.06524033
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06352295
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06250688
90SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05787438
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05635695
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04254861
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.02194201
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01673366
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.01412358
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.00614504
97* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00317690
98CDX2_20551321_ChIP-Seq_CACO-2_Human1.00156411
99* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99661776
100TBX20_22328084_ChIP-Seq_HEART_Mouse0.99395486
101TBX20_22080862_ChIP-Seq_HEART_Mouse0.99395486
102* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98735404
103KDM2B_26808549_Chip-Seq_DND41_Human0.98547136
104* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98509105
105EED_16625203_ChIP-ChIP_MESCs_Mouse0.98273209
106NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97605223
107CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97432491
108* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97352568
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97172288
110* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96561482
111TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96153580
112IRF8_21731497_ChIP-ChIP_J774_Mouse0.95029357
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94682004
114TP53_18474530_ChIP-ChIP_U2OS_Human0.93442116
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93072966
116RNF2_27304074_Chip-Seq_ESCs_Mouse0.92901242
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92892568
118* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91502522
119JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91399958
120* TP53_23651856_ChIP-Seq_MEFs_Mouse0.91291553
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91034128
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90460865
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.90419438
124* SMAD3_21741376_ChIP-Seq_EPCs_Human0.89444444
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89418992
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.89258856
127ELK3_25401928_ChIP-Seq_HUVEC_Human0.88757491
128GATA1_19941826_ChIP-Seq_K562_Human0.88547828
129TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88408009
130HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88289318
131JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87868451
132SOX2_20726797_ChIP-Seq_SW620_Human0.86380475
133* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86004834
134GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85798775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.96195654
2MP0003705_abnormal_hypodermis_morpholog3.96723528
3MP0005275_abnormal_skin_tensile2.94937511
4MP0004272_abnormal_basement_membrane2.72182667
5MP0001958_emphysema2.68659612
6MP0005058_abnormal_lysosome_morphology2.67573138
7MP0003690_abnormal_glial_cell2.66977022
8MP0000569_abnormal_digit_pigmentation2.66299439
9MP0005167_abnormal_blood-brain_barrier2.52999615
10MP0004858_abnormal_nervous_system2.43283830
11MP0003303_peritoneal_inflammation2.35981064
12MP0003300_gastrointestinal_ulcer2.24898461
13MP0005257_abnormal_intraocular_pressure2.02793913
14MP0003172_abnormal_lysosome_physiology2.00880206
15MP0003566_abnormal_cell_adhesion2.00151153
16MP0005623_abnormal_meninges_morphology1.96960441
17MP0000604_amyloidosis1.87318637
18MP0005360_urolithiasis1.83099475
19MP0003279_aneurysm1.82701391
20MP0004130_abnormal_muscle_cell1.81427147
21MP0003191_abnormal_cellular_cholesterol1.78734735
22MP0003045_fibrosis1.78734065
23MP0006054_spinal_hemorrhage1.76613339
24MP0009840_abnormal_foam_cell1.75382097
25MP0003941_abnormal_skin_development1.75230926
26MP0003091_abnormal_cell_migration1.74884250
27MP0002254_reproductive_system_inflammat1.74185741
28MP0003075_altered_response_to1.73925724
29MP0004859_abnormal_synaptic_plasticity1.68486882
30MP0005503_abnormal_tendon_morphology1.68219513
31MP0009780_abnormal_chondrocyte_physiolo1.47710396
32MP0009278_abnormal_bone_marrow1.47329875
33MP0004185_abnormal_adipocyte_glucose1.41258683
34MP0001542_abnormal_bone_strength1.41065620
35MP0010030_abnormal_orbit_morphology1.36871292
36MP0006138_congestive_heart_failure1.35838415
37MP0005409_darkened_coat_color1.35635306
38MP0010368_abnormal_lymphatic_system1.33172063
39MP0005076_abnormal_cell_differentiation1.32427424
40MP0002139_abnormal_hepatobiliary_system1.31700523
41MP0003252_abnormal_bile_duct1.30857740
42MP0002295_abnormal_pulmonary_circulatio1.30334630
43MP0010329_abnormal_lipoprotein_level1.30263470
44MP0000534_abnormal_ureter_morphology1.24538688
45MP0000751_myopathy1.24523239
46MP0005666_abnormal_adipose_tissue1.23725313
47MP0000749_muscle_degeneration1.21619685
48MP0002168_other_aberrant_phenotype1.21009287
49MP0005083_abnormal_biliary_tract1.20443518
50MP0005023_abnormal_wound_healing1.19990550
51MP0002796_impaired_skin_barrier1.19533429
52MP0004084_abnormal_cardiac_muscle1.17452229
53MP0003634_abnormal_glial_cell1.17144707
54MP0000920_abnormal_myelination1.15792243
55MP0000767_abnormal_smooth_muscle1.14668083
56MP0005670_abnormal_white_adipose1.14283558
57MP0003283_abnormal_digestive_organ1.12857106
58MP0000733_abnormal_muscle_development1.12734238
59MP0002998_abnormal_bone_remodeling1.12154893
60MP0004270_analgesia1.11086307
61MP0004510_myositis1.11037962
62MP0009250_abnormal_appendicular_skeleto1.10528080
63MP0009384_cardiac_valve_regurgitation1.10397077
64MP0002877_abnormal_melanocyte_morpholog1.09323908
65MP0003448_altered_tumor_morphology1.08079359
66MP0005164_abnormal_response_to1.07666445
67MP0005375_adipose_tissue_phenotype1.07456045
68MP0003329_amyloid_beta_deposits1.05591119
69MP0001879_abnormal_lymphatic_vessel1.04558295
70MP0000013_abnormal_adipose_tissue1.04144185
71MP0003828_pulmonary_edema1.01522387
72MP0002060_abnormal_skin_morphology1.01081465
73MP0002108_abnormal_muscle_morphology0.99100776
74MP0001299_abnormal_eye_distance/0.98620118
75MP0005171_absent_coat_pigmentation0.98598324
76MP0000428_abnormal_craniofacial_morphol0.98029921
77MP0010352_gastrointestinal_tract_polyps0.96900957
78MP0003633_abnormal_nervous_system0.95644316
79MP0004036_abnormal_muscle_relaxation0.95575091
80MP0000343_altered_response_to0.94833996
81MP0010234_abnormal_vibrissa_follicle0.94762268
82MP0002133_abnormal_respiratory_system0.92417466
83MP0005388_respiratory_system_phenotype0.92417466
84MP0002896_abnormal_bone_mineralization0.92370531
85MP0003453_abnormal_keratinocyte_physiol0.91683564
86MP0005620_abnormal_muscle_contractility0.90828095
87MP0005166_decreased_susceptibility_to0.90478665
88MP0005365_abnormal_bile_salt0.89767609
89MP0004885_abnormal_endolymph0.89489570
90MP0001533_abnormal_skeleton_physiology0.89433310
91MP0000003_abnormal_adipose_tissue0.88333048
92MP0002118_abnormal_lipid_homeostasis0.87470141
93MP0005595_abnormal_vascular_smooth0.87453361
94MP0003385_abnormal_body_wall0.87449978
95MP0003950_abnormal_plasma_membrane0.87005018
96MP0000762_abnormal_tongue_morphology0.85858115
97MP0000759_abnormal_skeletal_muscle0.83434347
98MP0000747_muscle_weakness0.83352725
99MP0005248_abnormal_Harderian_gland0.83084355
100MP0003942_abnormal_urinary_system0.82760930
101MP0003632_abnormal_nervous_system0.81237808
102MP0001177_atelectasis0.80042350
103MP0002971_abnormal_brown_adipose0.80028621
104MP0008961_abnormal_basal_metabolism0.79808234
105MP0008775_abnormal_heart_ventricle0.79234432
106MP0005508_abnormal_skeleton_morphology0.79092863
107MP0002090_abnormal_vision0.78747674
108MP0001915_intracranial_hemorrhage0.78587332
109MP0001614_abnormal_blood_vessel0.78159362
110MP0002128_abnormal_blood_circulation0.77677914
111MP0010678_abnormal_skin_adnexa0.77612178
112MP0005197_abnormal_uvea_morphology0.77114257
113MP0000249_abnormal_blood_vessel0.76445249
114MP0000163_abnormal_cartilage_morphology0.75206215
115MP0004087_abnormal_muscle_fiber0.75158189
116MP0004215_abnormal_myocardial_fiber0.74946165
117MP0004883_abnormal_blood_vessel0.74932666
118MP0005165_increased_susceptibility_to0.74589766
119MP0002332_abnormal_exercise_endurance0.73728284
120MP0002115_abnormal_skeleton_extremities0.73373551
121MP0010630_abnormal_cardiac_muscle0.72606252
122MP0009053_abnormal_anal_canal0.72137877
123MP0001849_ear_inflammation0.71212947
124MP0000432_abnormal_head_morphology0.69802030
125MP0002925_abnormal_cardiovascular_devel0.69714793
126MP0003935_abnormal_craniofacial_develop0.69541097
127MP0000778_abnormal_nervous_system0.69205967
128MP0003631_nervous_system_phenotype0.68950309
129MP0006082_CNS_inflammation0.68713421
130MP0005085_abnormal_gallbladder_physiolo0.68414171
131MP0005332_abnormal_amino_acid0.68153944
132MP0000750_abnormal_muscle_regeneration0.68006652
133MP0002972_abnormal_cardiac_muscle0.65431815
134MP0000049_abnormal_middle_ear0.63590546
135MP0005369_muscle_phenotype0.63543009
136MP0000462_abnormal_digestive_system0.63153396
137MP0003136_yellow_coat_color0.62306254
138MP0001243_abnormal_dermal_layer0.60451053
139MP0003755_abnormal_palate_morphology0.60250541
140MP0000579_abnormal_nail_morphology0.59015221
141MP0000467_abnormal_esophagus_morphology0.58949190

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.82786626
2Cerebral aneurysm (HP:0004944)3.77636933
3Protrusio acetabuli (HP:0003179)3.60919071
4Broad metatarsal (HP:0001783)3.42577214
5Shallow orbits (HP:0000586)3.18387996
6Increased cerebral lipofuscin (HP:0011813)3.11914008
7Myocardial infarction (HP:0001658)3.02709009
8Turricephaly (HP:0000262)2.98728230
9Wormian bones (HP:0002645)2.93624277
10Type 1 muscle fiber predominance (HP:0003803)2.89529839
11Neonatal short-limb short stature (HP:0008921)2.86955370
12Axonal loss (HP:0003447)2.66765593
13Mitral valve prolapse (HP:0001634)2.66316308
14Ankle contracture (HP:0006466)2.58887494
15Aortic dissection (HP:0002647)2.58771827
16Atrophic scars (HP:0001075)2.56976786
17Complement deficiency (HP:0004431)2.55518941
18Peritonitis (HP:0002586)2.55153111
19Hematochezia (HP:0002573)2.53398366
20Neurofibrillary tangles (HP:0002185)2.53258948
21Deep venous thrombosis (HP:0002625)2.44126650
22Increased connective tissue (HP:0009025)2.43599887
23Obstructive sleep apnea (HP:0002870)2.36783651
24Systemic lupus erythematosus (HP:0002725)2.36233902
25Wide anterior fontanel (HP:0000260)2.35693478
26Xanthomatosis (HP:0000991)2.35076909
27Bladder diverticulum (HP:0000015)2.32434499
28Cerebral inclusion bodies (HP:0100314)2.31982277
29Abnormality of dentin (HP:0010299)2.29360789
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.25816429
31Genu recurvatum (HP:0002816)2.25731377
32Dysostosis multiplex (HP:0000943)2.21696164
33Aortic aneurysm (HP:0004942)2.21494297
34Limited hip movement (HP:0008800)2.20255077
35Muscle fiber splitting (HP:0003555)2.20097485
36Dilatation of the ascending aorta (HP:0005111)2.18846059
37Increased CSF protein (HP:0002922)2.18605941
38Urinary glycosaminoglycan excretion (HP:0003541)2.17970976
39Mucopolysacchariduria (HP:0008155)2.17970976
40Action tremor (HP:0002345)2.14661892
41Aneurysm (HP:0002617)2.14354835
42Fragile skin (HP:0001030)2.13298495
43Skin nodule (HP:0200036)2.12109340
44Mitral regurgitation (HP:0001653)2.11984892
45Esophageal varix (HP:0002040)2.11883464
46Hypoalphalipoproteinemia (HP:0003233)2.11494443
47Ulnar bowing (HP:0003031)2.09853368
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09656163
49Abnormality of polysaccharide metabolism (HP:0011012)2.09656163
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09656163
51Amyloidosis (HP:0011034)2.09606168
52Abnormality of complement system (HP:0005339)2.08172308
53Thick nail (HP:0001805)2.07320245
54Supranuclear gaze palsy (HP:0000605)2.06895810
55Joint laxity (HP:0001388)2.06420630
56Hemiplegia (HP:0002301)2.01146414
57Aplasia involving bones of the extremities (HP:0009825)2.00325818
58Aplasia involving bones of the upper limbs (HP:0009823)2.00325818
59Aplasia of the phalanges of the hand (HP:0009802)2.00325818
60Vertebral compression fractures (HP:0002953)1.99939088
61Striae distensae (HP:0001065)1.99726117
62Peripheral demyelination (HP:0011096)1.99430148
63Alopecia of scalp (HP:0002293)1.99410053
64Hyperextensible skin (HP:0000974)1.99342552
65Osteolytic defects of the phalanges of the hand (HP:0009771)1.97729201
66Osteolytic defects of the hand bones (HP:0009699)1.97729201
67Bowel diverticulosis (HP:0005222)1.95739355
68Abnormality of skeletal muscle fiber size (HP:0012084)1.95399694
69Mildly elevated creatine phosphokinase (HP:0008180)1.95050517
70Spondylolisthesis (HP:0003302)1.94897422
71Aortic regurgitation (HP:0001659)1.94859302
72Mitral stenosis (HP:0001718)1.94608449
73Pulmonary artery stenosis (HP:0004415)1.94313194
74Nephritis (HP:0000123)1.92184169
75Bronchomalacia (HP:0002780)1.91392779
76Mild short stature (HP:0003502)1.91366744
77Vascular tortuosity (HP:0004948)1.90123043
78Blue sclerae (HP:0000592)1.90056989
79Aortic valve stenosis (HP:0001650)1.89628332
80Arterial tortuosity (HP:0005116)1.87859391
81Upper limb amyotrophy (HP:0009129)1.85821192
82Distal upper limb amyotrophy (HP:0007149)1.85821192
83Slender build (HP:0001533)1.85368917
84Abnormality of the Achilles tendon (HP:0005109)1.83709116
85Vertebral arch anomaly (HP:0008438)1.83478787
86Glomerulonephritis (HP:0000099)1.82525923
87Broad ribs (HP:0000885)1.81605473
88Cervical subluxation (HP:0003308)1.81500069
89Lymphangioma (HP:0100764)1.81302638
90Hip contracture (HP:0003273)1.81121116
91Ectopia lentis (HP:0001083)1.80771296
92Achilles tendon contracture (HP:0001771)1.80629881
93Coronal craniosynostosis (HP:0004440)1.79460251
94Soft skin (HP:0000977)1.79384892
95Abnormality of proline metabolism (HP:0010907)1.78404034
96Hydroxyprolinuria (HP:0003080)1.78404034
97Hypoplastic ischia (HP:0003175)1.78010009
98Disproportionate tall stature (HP:0001519)1.77938646
99Hypercholesterolemia (HP:0003124)1.77528853
100Follicular hyperkeratosis (HP:0007502)1.77266411
101Overgrowth (HP:0001548)1.77118328
102Difficulty running (HP:0009046)1.75159018
103Macroorchidism (HP:0000053)1.75081287
104Knee flexion contracture (HP:0006380)1.74083535
105Hammertoe (HP:0001765)1.73290763
106Camptodactyly of toe (HP:0001836)1.72788374
107Epidermoid cyst (HP:0200040)1.71835660
108Hypoventilation (HP:0002791)1.71247162
109Wrist flexion contracture (HP:0001239)1.70981704
110Neuronal loss in central nervous system (HP:0002529)1.69367612
111Focal segmental glomerulosclerosis (HP:0000097)1.69107186
112Round ear (HP:0100830)1.68979990
113Thin bony cortex (HP:0002753)1.68457947
114Abnormality of the acetabulum (HP:0003170)1.67391999
115Scapular winging (HP:0003691)1.66259608
116Hyperlipoproteinemia (HP:0010980)1.64455636
117Distal lower limb muscle weakness (HP:0009053)1.64397984
118Natal tooth (HP:0000695)1.64261404
119Biconcave vertebral bodies (HP:0004586)1.63889996
120Short nail (HP:0001799)1.63824866
121Hypoplasia of the iris (HP:0007676)1.62442874
122Abnormality of the ischium (HP:0003174)1.62307786
123Tetraparesis (HP:0002273)1.62264450
124Disinhibition (HP:0000734)1.62091890
125Spinal rigidity (HP:0003306)1.61736515
126Loss of speech (HP:0002371)1.61703249
127Infantile muscular hypotonia (HP:0008947)1.61535608
128Osteoarthritis (HP:0002758)1.60357300
129Increased variability in muscle fiber diameter (HP:0003557)1.59762019
130Abnormality of the periventricular white matter (HP:0002518)1.59270279
131Hyporeflexia of lower limbs (HP:0002600)1.59206995
132Global brain atrophy (HP:0002283)1.58475129
133Lower limb amyotrophy (HP:0007210)1.58470368
134Tibial bowing (HP:0002982)1.57645890
135Asymmetric septal hypertrophy (HP:0001670)1.57480560
136Hemorrhage of the eye (HP:0011885)1.56864626
137Elbow flexion contracture (HP:0002987)1.56338727
138Venous abnormality (HP:0002624)1.55688449
139Urethral obstruction (HP:0000796)1.55066866
140Venous insufficiency (HP:0005293)1.54756330
141Spinal cord compression (HP:0002176)1.53805094
142Protruding ear (HP:0000411)1.52020894
143Bell-shaped thorax (HP:0001591)1.51449094
144Arnold-Chiari malformation (HP:0002308)1.49345833
145Coxa vara (HP:0002812)1.48070055
146Cardiovascular calcification (HP:0011915)1.47813714
147Pulmonic stenosis (HP:0001642)1.47181040
148Abnormal delivery (HP:0001787)1.45603833
149Broad long bones (HP:0005622)1.45257984
150Bradycardia (HP:0001662)1.44947763
151Laryngomalacia (HP:0001601)1.42429939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.05147357
2RIPK12.93004846
3DDR22.70057475
4CAMK1D2.67047657
5CAMK1G2.42903341
6PDGFRA2.30913243
7MYLK2.20013768
8SIK12.05981889
9AKT32.03456108
10ERN12.01892624
11LATS11.97579730
12TTN1.95667841
13MARK11.95145893
14BMX1.90640633
15EPHB11.74355962
16DMPK1.66987509
17PTK61.66631794
18PKN21.61982271
19TYRO31.60581821
20MAP3K91.55381693
21NTRK11.53393196
22PRKD31.52806413
23TGFBR21.49234911
24KSR21.47558451
25DAPK21.36830715
26PAK61.36284934
27LATS21.31832685
28FGR1.31173298
29PDGFRB1.29217261
30EEF2K1.27327874
31ICK1.25977231
32STK38L1.24589616
33LMTK21.21433350
34JAK11.19919558
35FGFR21.18140228
36FER1.14855754
37STK381.13634340
38MAPK71.12639263
39MAP3K131.11747070
40RIPK41.10737992
41CAMKK11.10653599
42PTK21.09712981
43CSK1.05873288
44PRKCH1.05648292
45FES1.04978937
46MAP3K21.03138768
47CDK121.02942685
48TRPM71.01748933
49MET1.00345993
50RET0.98536889
51SGK30.98091202
52ROCK20.94872118
53FGFR40.94747211
54FGFR30.94499814
55PTK2B0.93395421
56STK240.92914195
57PNCK0.92754774
58EPHA40.90460882
59TIE10.90119236
60CDK60.90108563
61MAPK120.89712437
62ERBB20.84060312
63ERBB40.79750010
64MAP3K60.79170394
65MTOR0.78396933
66TGFBR10.78043414
67PRKD10.77923100
68ABL20.76977486
69PHKG20.76263564
70PHKG10.76263564
71TBK10.76028540
72CASK0.75664522
73WNK10.75460593
74EPHB20.75394793
75ALK0.74261815
76TYK20.73997652
77NTRK30.73616488
78JAK20.72800982
79CAMK2B0.72173879
80GSK3A0.71824964
81PDPK10.71115656
82KIT0.70998136
83PAK20.69549604
84NTRK20.69192849
85EGFR0.68621598
86PRKAA20.68168669
87SCYL20.67635528
88CAMK10.67322945
89TAOK10.66927005
90SIK20.66506394
91RPS6KA20.66041354
92PKN10.65552366
93CAMK2G0.63015837
94FYN0.62429813
95PAK30.60981150
96STK390.60903273
97SRC0.60215976
98MAP3K70.59901050
99LIMK10.59767075
100STK30.59283857
101MOS0.57209451
102ROCK10.56895967
103KDR0.56684554
104EPHA30.56680207
105MST1R0.55714763
106MAP2K10.55410714
107SGK10.54385850
108PAK40.54139788
109HCK0.53627404
110MATK0.52987284
111NEK90.52829051
112INSR0.52051163
113TNIK0.51682004
114MAP3K10.51487104
115CDC42BPA0.51216828
116PRKCE0.50823697
117MAPK100.50518123
118FGFR10.50472353
119CDK50.50314313
120ABL10.49506543
121PRKG20.49217064
122SGK2230.49127514
123SGK4940.49127514
124PRKD20.48993492
125PLK20.48892029
126MAP2K40.47777810
127CAMK2D0.46541693
128SGK20.45940509
129GRK50.45558223
130CAMK40.45357566
131MARK20.43343719
132PDK10.42757040
133CAMK2A0.39922650
134UHMK10.37794399
135MAPK40.37553288
136MAPKAPK50.37281806

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.39195672
2Staphylococcus aureus infection_Homo sapiens_hsa051501.79069198
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71827344
4Arginine biosynthesis_Homo sapiens_hsa002201.69124434
5ECM-receptor interaction_Homo sapiens_hsa045121.53543406
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44846368
7PPAR signaling pathway_Homo sapiens_hsa033201.44463651
8Complement and coagulation cascades_Homo sapiens_hsa046101.42316988
9Fatty acid biosynthesis_Homo sapiens_hsa000611.41154554
10Dorso-ventral axis formation_Homo sapiens_hsa043201.36199995
11Bile secretion_Homo sapiens_hsa049761.36003577
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.35667024
13Melanogenesis_Homo sapiens_hsa049161.27526374
14Vascular smooth muscle contraction_Homo sapiens_hsa042701.27520119
15Focal adhesion_Homo sapiens_hsa045101.27100562
16Lysosome_Homo sapiens_hsa041421.25975291
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.24865561
18Hippo signaling pathway_Homo sapiens_hsa043901.24474685
19Amoebiasis_Homo sapiens_hsa051461.22159029
20Tight junction_Homo sapiens_hsa045301.20773350
21Glutamatergic synapse_Homo sapiens_hsa047241.18960288
22Caffeine metabolism_Homo sapiens_hsa002321.18856453
23Long-term potentiation_Homo sapiens_hsa047201.17587823
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16856784
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16024910
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16010718
27Proteoglycans in cancer_Homo sapiens_hsa052051.11462991
28Circadian entrainment_Homo sapiens_hsa047131.09111355
29Fatty acid metabolism_Homo sapiens_hsa012121.06105171
30Basal cell carcinoma_Homo sapiens_hsa052171.05483648
31Circadian rhythm_Homo sapiens_hsa047101.03928335
32Histidine metabolism_Homo sapiens_hsa003401.02965514
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01888838
34Hedgehog signaling pathway_Homo sapiens_hsa043401.01666809
35Oxytocin signaling pathway_Homo sapiens_hsa049211.00228023
36TGF-beta signaling pathway_Homo sapiens_hsa043500.99955878
37Malaria_Homo sapiens_hsa051440.99634904
38Fatty acid degradation_Homo sapiens_hsa000710.99202810
39Type II diabetes mellitus_Homo sapiens_hsa049300.98452305
40Thyroid hormone synthesis_Homo sapiens_hsa049180.97033359
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96660672
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96362106
43Insulin secretion_Homo sapiens_hsa049110.95742851
44Adherens junction_Homo sapiens_hsa045200.94624340
45Ras signaling pathway_Homo sapiens_hsa040140.94379596
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.93999616
47Glioma_Homo sapiens_hsa052140.92586912
48Dilated cardiomyopathy_Homo sapiens_hsa054140.92529705
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91505052
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87643856
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86571832
52Cocaine addiction_Homo sapiens_hsa050300.86519672
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85951503
54Morphine addiction_Homo sapiens_hsa050320.85587618
55Osteoclast differentiation_Homo sapiens_hsa043800.83939552
56Pathways in cancer_Homo sapiens_hsa052000.83530634
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.83356158
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81898427
59Calcium signaling pathway_Homo sapiens_hsa040200.81503422
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80884519
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79536126
62Long-term depression_Homo sapiens_hsa047300.79466564
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79463441
64Nicotine addiction_Homo sapiens_hsa050330.78684099
65Wnt signaling pathway_Homo sapiens_hsa043100.78563016
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78526324
67Protein digestion and absorption_Homo sapiens_hsa049740.78382089
68Lysine degradation_Homo sapiens_hsa003100.78251021
69Amphetamine addiction_Homo sapiens_hsa050310.77950474
70Dopaminergic synapse_Homo sapiens_hsa047280.77835424
71Insulin resistance_Homo sapiens_hsa049310.77529746
72Gastric acid secretion_Homo sapiens_hsa049710.77433267
73Prion diseases_Homo sapiens_hsa050200.76936751
74mTOR signaling pathway_Homo sapiens_hsa041500.75582436
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75355553
76Cholinergic synapse_Homo sapiens_hsa047250.73849492
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73527616
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73520824
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73430302
80Renal cell carcinoma_Homo sapiens_hsa052110.72565292
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69498324
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69314296
83MAPK signaling pathway_Homo sapiens_hsa040100.68795247
84Salivary secretion_Homo sapiens_hsa049700.68018811
85Rap1 signaling pathway_Homo sapiens_hsa040150.67878623
86Mineral absorption_Homo sapiens_hsa049780.67866674
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67720966
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67604670
89Renin secretion_Homo sapiens_hsa049240.67286843
90Small cell lung cancer_Homo sapiens_hsa052220.66216616
91Tuberculosis_Homo sapiens_hsa051520.64549510
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.63507065
93Phagosome_Homo sapiens_hsa041450.62955813
94Prostate cancer_Homo sapiens_hsa052150.62386309
95Sphingolipid metabolism_Homo sapiens_hsa006000.62381647
96Estrogen signaling pathway_Homo sapiens_hsa049150.62355669
97Chronic myeloid leukemia_Homo sapiens_hsa052200.61961166
98VEGF signaling pathway_Homo sapiens_hsa043700.61358795
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61257548
100Butanoate metabolism_Homo sapiens_hsa006500.60427850
101GnRH signaling pathway_Homo sapiens_hsa049120.60418966
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60318751
103Bladder cancer_Homo sapiens_hsa052190.59811232
104Synaptic vesicle cycle_Homo sapiens_hsa047210.58786910
105MicroRNAs in cancer_Homo sapiens_hsa052060.58665491
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58115448
107Axon guidance_Homo sapiens_hsa043600.58096622
108Pancreatic secretion_Homo sapiens_hsa049720.57998621
109Ovarian steroidogenesis_Homo sapiens_hsa049130.57692824
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57138592
111Platelet activation_Homo sapiens_hsa046110.57124504
112Pertussis_Homo sapiens_hsa051330.57068221
113Pancreatic cancer_Homo sapiens_hsa052120.56958206
114Endocytosis_Homo sapiens_hsa041440.56558083
115Toxoplasmosis_Homo sapiens_hsa051450.56346552
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55957901
117Glycerolipid metabolism_Homo sapiens_hsa005610.55812906
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.55726785
119Leishmaniasis_Homo sapiens_hsa051400.55157893
120Choline metabolism in cancer_Homo sapiens_hsa052310.53740516
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53714628
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53552553
123Tryptophan metabolism_Homo sapiens_hsa003800.53161356
124cAMP signaling pathway_Homo sapiens_hsa040240.52562085
125TNF signaling pathway_Homo sapiens_hsa046680.52198773
126Gap junction_Homo sapiens_hsa045400.52150003
127Melanoma_Homo sapiens_hsa052180.51807507
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51214068
129GABAergic synapse_Homo sapiens_hsa047270.51055111
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.50452244
131Notch signaling pathway_Homo sapiens_hsa043300.50109187
132Salmonella infection_Homo sapiens_hsa051320.49107571
133African trypanosomiasis_Homo sapiens_hsa051430.48972202
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48082929
135ABC transporters_Homo sapiens_hsa020100.47842467
136Insulin signaling pathway_Homo sapiens_hsa049100.47702668
137ErbB signaling pathway_Homo sapiens_hsa040120.47331078
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.47072206
139AMPK signaling pathway_Homo sapiens_hsa041520.47062240
140Endometrial cancer_Homo sapiens_hsa052130.46788268

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