SAR1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.47235941
2L-phenylalanine catabolic process (GO:0006559)6.47235941
3L-phenylalanine metabolic process (GO:0006558)6.20440626
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.20440626
5aromatic amino acid family catabolic process (GO:0009074)5.44011692
6glyoxylate metabolic process (GO:0046487)4.96255030
7regulation of glucokinase activity (GO:0033131)4.88400547
8regulation of hexokinase activity (GO:1903299)4.88400547
9bile acid biosynthetic process (GO:0006699)4.76917168
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.67115155
11signal peptide processing (GO:0006465)4.58131750
12sulfur amino acid catabolic process (GO:0000098)4.56284252
13indole-containing compound catabolic process (GO:0042436)4.51996307
14indolalkylamine catabolic process (GO:0046218)4.51996307
15tryptophan catabolic process (GO:0006569)4.51996307
16fatty acid elongation (GO:0030497)4.50609936
17tryptophan metabolic process (GO:0006568)4.33224505
18aldehyde catabolic process (GO:0046185)4.32299583
19kynurenine metabolic process (GO:0070189)4.31409758
20cellular ketone body metabolic process (GO:0046950)4.30688598
21cysteine metabolic process (GO:0006534)4.23783857
22alpha-linolenic acid metabolic process (GO:0036109)4.20312943
23bile acid metabolic process (GO:0008206)4.14460535
24aromatic amino acid family metabolic process (GO:0009072)4.08687716
25high-density lipoprotein particle remodeling (GO:0034375)4.02082400
26coenzyme catabolic process (GO:0009109)4.01067507
27tyrosine metabolic process (GO:0006570)3.99731087
28water-soluble vitamin biosynthetic process (GO:0042364)3.87950309
29triglyceride homeostasis (GO:0070328)3.86624597
30acylglycerol homeostasis (GO:0055090)3.86624597
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.85580626
32regulation of cholesterol esterification (GO:0010872)3.82004071
33very-low-density lipoprotein particle assembly (GO:0034379)3.81344163
34regulation of fibrinolysis (GO:0051917)3.75761417
35cellular glucuronidation (GO:0052695)3.74972886
36acetyl-CoA metabolic process (GO:0006084)3.74896985
37alpha-amino acid catabolic process (GO:1901606)3.74393941
38positive regulation of glycolytic process (GO:0045821)3.74038837
39ketone body metabolic process (GO:1902224)3.73008333
40regulation of triglyceride catabolic process (GO:0010896)3.72515408
41protein carboxylation (GO:0018214)3.71875772
42peptidyl-glutamic acid carboxylation (GO:0017187)3.71875772
43serine family amino acid catabolic process (GO:0009071)3.71448189
44very long-chain fatty acid metabolic process (GO:0000038)3.70750694
45negative regulation of fibrinolysis (GO:0051918)3.68019197
46cofactor catabolic process (GO:0051187)3.67000746
47short-chain fatty acid metabolic process (GO:0046459)3.65379662
48heme transport (GO:0015886)3.64628500
49lysine metabolic process (GO:0006553)3.62041900
50lysine catabolic process (GO:0006554)3.62041900
51regulation of protein activation cascade (GO:2000257)3.59522051
52cellular amino acid catabolic process (GO:0009063)3.59251322
53glucuronate metabolic process (GO:0019585)3.58813155
54uronic acid metabolic process (GO:0006063)3.58813155
55cholesterol efflux (GO:0033344)3.57937664
56urea cycle (GO:0000050)3.55159663
57urea metabolic process (GO:0019627)3.55159663
58respiratory chain complex IV assembly (GO:0008535)3.54917728
59inositol phosphate catabolic process (GO:0071545)3.53573667
60cholesterol biosynthetic process (GO:0006695)3.51246621
61fatty acid beta-oxidation (GO:0006635)3.49794453
62reverse cholesterol transport (GO:0043691)3.49140781
63plasma lipoprotein particle remodeling (GO:0034369)3.48446548
64protein-lipid complex remodeling (GO:0034368)3.48446548
65macromolecular complex remodeling (GO:0034367)3.48446548
66complement activation, alternative pathway (GO:0006957)3.47587715
67cellular biogenic amine catabolic process (GO:0042402)3.47556664
68amine catabolic process (GO:0009310)3.47556664
69amino-acid betaine metabolic process (GO:0006577)3.45863795
70fatty acid catabolic process (GO:0009062)3.45789282
71mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44280316
72nitrogen cycle metabolic process (GO:0071941)3.41339429
73mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.41010532
74indolalkylamine metabolic process (GO:0006586)3.40296853
75acyl-CoA metabolic process (GO:0006637)3.39307130
76thioester metabolic process (GO:0035383)3.39307130
77organic acid catabolic process (GO:0016054)3.38412281
78carboxylic acid catabolic process (GO:0046395)3.38412281
79monocarboxylic acid catabolic process (GO:0072329)3.38310618
80fatty-acyl-CoA biosynthetic process (GO:0046949)3.37425080
81fatty acid oxidation (GO:0019395)3.35928864
82lactate metabolic process (GO:0006089)3.35333525
83regulation of complement activation (GO:0030449)3.34210717
84ethanol oxidation (GO:0006069)3.33503856
85acyl-CoA biosynthetic process (GO:0071616)3.33316686
86thioester biosynthetic process (GO:0035384)3.33316686
87lipid oxidation (GO:0034440)3.30787767
88aspartate family amino acid catabolic process (GO:0009068)3.30083612
89intestinal cholesterol absorption (GO:0030299)3.28390298
90endocrine pancreas development (GO:0031018)3.28368480
91ATP synthesis coupled proton transport (GO:0015986)3.28108330
92energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28108330
93branched-chain amino acid catabolic process (GO:0009083)3.27529769
94homocysteine metabolic process (GO:0050667)3.26929341
95fatty-acyl-CoA metabolic process (GO:0035337)3.26749156
96bile acid and bile salt transport (GO:0015721)3.24631492
97plasma lipoprotein particle clearance (GO:0034381)3.24231154
98benzene-containing compound metabolic process (GO:0042537)3.23663247
99glutamate metabolic process (GO:0006536)3.22444621
100serine family amino acid metabolic process (GO:0009069)3.21245995
101phospholipid efflux (GO:0033700)3.20939359
102alkaloid metabolic process (GO:0009820)3.20444489
103regulation of type B pancreatic cell apoptotic process (GO:2000674)3.19944800
104proline metabolic process (GO:0006560)3.18511426
105drug catabolic process (GO:0042737)3.18188287
106polyol catabolic process (GO:0046174)3.17515601
107positive regulation of triglyceride lipase activity (GO:0061365)3.15856544
108positive regulation of lipoprotein lipase activity (GO:0051006)3.15856544
109macroautophagy (GO:0016236)3.13371914
110opsonization (GO:0008228)3.13024531
111serine family amino acid biosynthetic process (GO:0009070)3.12390275
112inositol phosphate dephosphorylation (GO:0046855)3.12334112
113phosphorylated carbohydrate dephosphorylation (GO:0046838)3.12334112
114respiratory electron transport chain (GO:0022904)3.11829461
115regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.08226801
116cytochrome complex assembly (GO:0017004)3.07772705
117glycerophospholipid catabolic process (GO:0046475)3.01475455
118exogenous drug catabolic process (GO:0042738)2.98168867
119insulin secretion (GO:0030073)2.87762576
120positive regulation of protein autophosphorylation (GO:0031954)2.87419689
121regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.87037054
122S-adenosylmethionine metabolic process (GO:0046500)2.86119211
123regulation of protein glycosylation (GO:0060049)2.85067457
124establishment of protein localization to Golgi (GO:0072600)2.82190152
125oxidative demethylation (GO:0070989)2.82037877
126xenobiotic catabolic process (GO:0042178)2.81286965
127positive regulation of insulin secretion (GO:0032024)2.79771017
128righting reflex (GO:0060013)2.79456259
129positive regulation of peptide hormone secretion (GO:0090277)2.77883591
130regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.76365161
131UDP-N-acetylglucosamine metabolic process (GO:0006047)2.75641075
132peptide hormone processing (GO:0016486)2.74093350
133reflex (GO:0060004)2.72681740
134response to pheromone (GO:0019236)2.66436781
135detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66148409
136positive regulation of peptide secretion (GO:0002793)2.65653863
137zinc ion transport (GO:0006829)2.65375496
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64851960
139epoxygenase P450 pathway (GO:0019373)2.64092757
140detection of calcium ion (GO:0005513)2.56452132
141protein K11-linked deubiquitination (GO:0035871)2.55768102
142negative regulation of hormone biosynthetic process (GO:0032353)2.54337727
143protein targeting to Golgi (GO:0000042)2.53226645
144nucleotide transmembrane transport (GO:1901679)2.49705491
145protein prenylation (GO:0018342)2.49575695
146prenylation (GO:0097354)2.49575695
147dopamine transport (GO:0015872)2.49541937
148nitric oxide mediated signal transduction (GO:0007263)2.48910402
149flavonoid metabolic process (GO:0009812)2.48061473
150auditory receptor cell differentiation (GO:0042491)2.42742521
151positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.40670810
152regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.40051926
153regulation of energy homeostasis (GO:2000505)2.39934244
154proline transport (GO:0015824)2.39460788
155omega-hydroxylase P450 pathway (GO:0097267)2.39425702
156positive regulation of meiosis (GO:0045836)2.39340166
157phenylpropanoid metabolic process (GO:0009698)2.38210737
158lipid particle organization (GO:0034389)2.37802734
159regulation of acrosome reaction (GO:0060046)2.36426570
160protein localization to Golgi apparatus (GO:0034067)2.35581485
161retinol metabolic process (GO:0042572)2.35311826
162negative regulation of protein activation cascade (GO:2000258)2.34400221
163organic cation transport (GO:0015695)2.34207793
164positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.33946958
165mannosylation (GO:0097502)2.33819019
166protein complex biogenesis (GO:0070271)2.33051107
167negative regulation of hormone metabolic process (GO:0032351)2.33030083
168fatty acid homeostasis (GO:0055089)2.32489026
169intra-Golgi vesicle-mediated transport (GO:0006891)2.30483057
170retrograde transport, vesicle recycling within Golgi (GO:0000301)2.30008799
171negative regulation of complement activation (GO:0045916)2.29814263
172fatty acid transmembrane transport (GO:1902001)2.29027682
173negative regulation of protein oligomerization (GO:0032460)2.28432565
174adaptation of signaling pathway (GO:0023058)2.28024459
175protein localization to cilium (GO:0061512)2.27752493
176phospholipid homeostasis (GO:0055091)2.27256425
177thyroid hormone metabolic process (GO:0042403)2.26171292
178L-fucose metabolic process (GO:0042354)2.25444532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.36349150
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.01155483
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.08116240
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.97673871
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.55116884
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.25604084
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.21510629
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.93800644
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.76690656
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.41310022
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34143711
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.66006019
13ZNF274_21170338_ChIP-Seq_K562_Hela2.44413479
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.32630368
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.20644249
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.15072159
17HTT_18923047_ChIP-ChIP_STHdh_Human2.10100662
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98327159
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96311919
20P300_19829295_ChIP-Seq_ESCs_Human1.94384514
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.92153756
22FUS_26573619_Chip-Seq_HEK293_Human1.91025105
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90793257
24IGF1R_20145208_ChIP-Seq_DFB_Human1.87836792
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87049591
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.86273964
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84509430
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82768490
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81846227
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80601517
31SMAD4_21799915_ChIP-Seq_A2780_Human1.79268417
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70253267
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.67664916
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65174134
35STAT3_23295773_ChIP-Seq_U87_Human1.63035173
36EWS_26573619_Chip-Seq_HEK293_Human1.60359637
37VDR_22108803_ChIP-Seq_LS180_Human1.60355866
38AR_25329375_ChIP-Seq_VCAP_Human1.56932321
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55744604
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.53069193
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50100085
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.49895368
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49146439
44* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48980351
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48252887
46CBP_20019798_ChIP-Seq_JUKART_Human1.48252887
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47630554
48TCF4_23295773_ChIP-Seq_U87_Human1.47554019
49CDX2_22108803_ChIP-Seq_LS180_Human1.47035776
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46851064
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.45638673
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.45593692
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43402022
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.43254203
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42161751
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.41965450
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41418507
58TCF4_22108803_ChIP-Seq_LS180_Human1.36804728
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35003129
60P53_22387025_ChIP-Seq_ESCs_Mouse1.34474208
61TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31087823
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29125897
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28142790
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25581381
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24868806
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.22802316
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22359955
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22073917
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20955832
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20718808
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.19892936
72SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19737023
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.18692618
74OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18348936
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17640772
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17578787
77TP53_22573176_ChIP-Seq_HFKS_Human1.17441190
78TAF15_26573619_Chip-Seq_HEK293_Human1.16768346
79* FLI1_21867929_ChIP-Seq_TH2_Mouse1.15561658
80SOX2_18555785_Chip-Seq_ESCs_Mouse1.13190839
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13016253
82P300_18555785_Chip-Seq_ESCs_Mouse1.12181811
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12041406
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.12041406
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09920640
86RUNX2_22187159_ChIP-Seq_PCA_Human1.09577644
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08969350
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08640413
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08014919
90CJUN_26792858_Chip-Seq_BT549_Human1.07983307
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07002648
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06482441
93RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06427408
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06238489
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.02861663
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.02648929
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02404742
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01737191
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.01679656
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.01620145
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.01390992
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01305616
103NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00640736
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00640736
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00183219
106CTCF_18555785_Chip-Seq_ESCs_Mouse0.99861874
107NMYC_18555785_Chip-Seq_ESCs_Mouse0.99801832
108IRF1_19129219_ChIP-ChIP_H3396_Human0.96737942
109AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90151712
110CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.87929941
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86514975
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85389498
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84683594
114* HNF4A_19822575_ChIP-Seq_HepG2_Human0.83429264
115ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82708758
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82142568
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82070857
118CLOCK_20551151_ChIP-Seq_293T_Human0.82003413
119* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81455338
120CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81384340
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.81073904
122SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80370141
123TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80343952
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78716336
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77405755
126AR_20517297_ChIP-Seq_VCAP_Human0.75425203
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75094391
128ETS1_20019798_ChIP-Seq_JURKAT_Human0.74019499
129CRX_20693478_ChIP-Seq_RETINA_Mouse0.72731421
130SOX2_19829295_ChIP-Seq_ESCs_Human0.72578422
131NANOG_19829295_ChIP-Seq_ESCs_Human0.72578422
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.72363363
133FOXA2_19822575_ChIP-Seq_HepG2_Human0.71965999
134NCOR_22424771_ChIP-Seq_293T_Human0.70666898
135OCT4_20526341_ChIP-Seq_ESCs_Human0.70495088
136KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69688154
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.67691471
138NANOG_20526341_ChIP-Seq_ESCs_Human0.67425424
139RUNX1_27457419_Chip-Seq_LIVER_Mouse0.65962993
140FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.65940988
141PHF8_20622853_ChIP-Seq_HELA_Human0.64074876
142GATA1_22025678_ChIP-Seq_K562_Human0.64019421
143STAT1_20625510_ChIP-Seq_HELA_Human0.63709041
144GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.63628748
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63327911
146E2F1_18555785_ChIP-Seq_MESCs_Mouse0.63190267
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63157512
148EOMES_21245162_ChIP-Seq_HESCs_Human0.63137353
149ETV2_25802403_ChIP-Seq_MESCs_Mouse0.63093211
150RARA_24833708_ChIP-Seq_LIVER_Mouse0.63034625
151FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62813693
152RARB_24833708_ChIP-Seq_LIVER_Mouse0.62404703
153CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.62108015
154GBX2_23144817_ChIP-Seq_PC3_Human0.60862856
155CBP_21632823_ChIP-Seq_H3396_Human0.60605706
156SUZ12_27294783_Chip-Seq_NPCs_Mouse0.60369735
157REST_19997604_ChIP-ChIP_NEURONS_Mouse0.60301750
158ERG_20517297_ChIP-Seq_VCAP_Human0.60198248
159SMAD1_18555785_Chip-Seq_ESCs_Mouse0.59948100
160SOX17_20123909_ChIP-Seq_XEN_Mouse0.59925040
161SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59704646
162THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.58015391
163EZH2_27294783_Chip-Seq_NPCs_Mouse0.57796602
164STAT3_18555785_Chip-Seq_ESCs_Mouse0.55976949
165GATA6_21074721_ChIP-Seq_CACO-2_Human0.55574590
166POU3F2_20337985_ChIP-ChIP_501MEL_Human0.55314878
167BCAT_22108803_ChIP-Seq_LS180_Human0.54659086
168GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.54446445
169CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.53013868
170ER_23166858_ChIP-Seq_MCF-7_Human0.53002436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.17560816
2MP0005360_urolithiasis5.91732685
3MP0005085_abnormal_gallbladder_physiolo5.54556005
4MP0005365_abnormal_bile_salt5.15123322
5MP0003806_abnormal_nucleotide_metabolis4.74888635
6MP0008875_abnormal_xenobiotic_pharmacok4.65189815
7MP0009780_abnormal_chondrocyte_physiolo3.33747957
8MP0003195_calcinosis3.25232828
9MP0010329_abnormal_lipoprotein_level2.73573890
10MP0005332_abnormal_amino_acid2.70458943
11MP0003252_abnormal_bile_duct2.68401766
12MP0009840_abnormal_foam_cell2.63248849
13MP0005083_abnormal_biliary_tract2.55560924
14MP0001666_abnormal_nutrient_absorption2.42099329
15MP0002909_abnormal_adrenal_gland2.24029623
16MP0006036_abnormal_mitochondrial_physio2.03908765
17MP0005645_abnormal_hypothalamus_physiol2.00066166
18MP0002837_dystrophic_cardiac_calcinosis1.99939839
19MP0005451_abnormal_body_composition1.99869511
20MP0002118_abnormal_lipid_homeostasis1.95335955
21MP0002102_abnormal_ear_morphology1.95263017
22MP0004019_abnormal_vitamin_homeostasis1.91043165
23MP0000013_abnormal_adipose_tissue1.88385733
24MP0009046_muscle_twitch1.82020549
25MP0009697_abnormal_copulation1.81481294
26MP0003787_abnormal_imprinting1.77447653
27MP0001944_abnormal_pancreas_morphology1.76949099
28MP0000427_abnormal_hair_cycle1.75017968
29MP0002693_abnormal_pancreas_physiology1.71455427
30MP0001764_abnormal_homeostasis1.70514663
31MP0000569_abnormal_digit_pigmentation1.68354850
32MP0010234_abnormal_vibrissa_follicle1.66936221
33MP0002163_abnormal_gland_morphology1.65337648
34MP0008877_abnormal_DNA_methylation1.64513269
35MP0003191_abnormal_cellular_cholesterol1.61227429
36MP0000609_abnormal_liver_physiology1.59665008
37MP0002638_abnormal_pupillary_reflex1.59249012
38MP0004215_abnormal_myocardial_fiber1.55495140
39MP0005319_abnormal_enzyme/_coenzyme1.54953503
40MP0005253_abnormal_eye_physiology1.54110434
41MP0002138_abnormal_hepatobiliary_system1.53126198
42MP0003186_abnormal_redox_activity1.51822615
43MP0005584_abnormal_enzyme/coenzyme_acti1.51363236
44MP0004043_abnormal_pH_regulation1.51051203
45MP0003656_abnormal_erythrocyte_physiolo1.48319282
46MP0004145_abnormal_muscle_electrophysio1.46734460
47MP0010386_abnormal_urinary_bladder1.44750061
48MP0000372_irregular_coat_pigmentation1.43669190
49MP0005646_abnormal_pituitary_gland1.42982684
50MP0003011_delayed_dark_adaptation1.42746078
51MP0003283_abnormal_digestive_organ1.40876547
52MP0002254_reproductive_system_inflammat1.40087523
53MP0003646_muscle_fatigue1.39144285
54MP0001501_abnormal_sleep_pattern1.37435552
55MP0002090_abnormal_vision1.37124974
56MP0001756_abnormal_urination1.36653057
57MP0000749_muscle_degeneration1.33882518
58MP0003868_abnormal_feces_composition1.31334881
59MP0006035_abnormal_mitochondrial_morpho1.26708292
60MP0002876_abnormal_thyroid_physiology1.26359580
61MP0004270_analgesia1.21854007
62MP0001986_abnormal_taste_sensitivity1.21780351
63MP0003329_amyloid_beta_deposits1.20506151
64MP0005386_behavior/neurological_phenoty1.18281953
65MP0004924_abnormal_behavior1.18281953
66MP0005266_abnormal_metabolism1.15938016
67MP0001661_extended_life_span1.15728200
68MP0001529_abnormal_vocalization1.12686747
69MP0005636_abnormal_mineral_homeostasis1.12398785
70MP0002938_white_spotting1.12185806
71MP0009643_abnormal_urine_homeostasis1.11608792
72MP0005367_renal/urinary_system_phenotyp1.11089048
73MP0000516_abnormal_urinary_system1.11089048
74MP0008872_abnormal_physiological_respon1.10617285
75MP0004142_abnormal_muscle_tone1.08884297
76MP0002269_muscular_atrophy1.08278505
77MP0009745_abnormal_behavioral_response1.08024087
78MP0004130_abnormal_muscle_cell1.07941235
79MP0003718_maternal_effect1.07713656
80MP0008775_abnormal_heart_ventricle1.03378484
81MP0001485_abnormal_pinna_reflex1.03221207
82MP0000604_amyloidosis1.03134671
83MP0005376_homeostasis/metabolism_phenot1.02483480
84MP0000747_muscle_weakness1.02054168
85MP0004036_abnormal_muscle_relaxation1.00675344
86MP0002822_catalepsy0.99566658
87MP0010678_abnormal_skin_adnexa0.98802902
88MP0002272_abnormal_nervous_system0.96457182
89MP0002078_abnormal_glucose_homeostasis0.96196188
90MP0002928_abnormal_bile_duct0.94371697
91MP0001765_abnormal_ion_homeostasis0.90933906
92MP0004085_abnormal_heartbeat0.90489368
93MP0005535_abnormal_body_temperature0.88853267
94MP0000920_abnormal_myelination0.88775938
95MP0001905_abnormal_dopamine_level0.88444921
96MP0002971_abnormal_brown_adipose0.88225045
97MP0004484_altered_response_of0.88020782
98MP0002064_seizures0.86981591
99MP0001486_abnormal_startle_reflex0.86365205
100MP0005058_abnormal_lysosome_morphology0.85053516
101MP0003633_abnormal_nervous_system0.85030804
102MP0003045_fibrosis0.84751653
103MP0002168_other_aberrant_phenotype0.84532058
104MP0003690_abnormal_glial_cell0.84467172
105MP0000003_abnormal_adipose_tissue0.84198706
106MP0005084_abnormal_gallbladder_morpholo0.83982958
107MP0005408_hypopigmentation0.82260253
108MP0002332_abnormal_exercise_endurance0.80784187
109MP0000566_synostosis0.79405705
110MP0003137_abnormal_impulse_conducting0.78883511
111MP0002557_abnormal_social/conspecific_i0.77347195
112MP0005174_abnormal_tail_pigmentation0.77345042
113MP0005220_abnormal_exocrine_pancreas0.76438662
114MP0005379_endocrine/exocrine_gland_phen0.76031863
115MP0009379_abnormal_foot_pigmentation0.75007426
116MP0005330_cardiomyopathy0.74708045
117MP0005647_abnormal_sex_gland0.72648385
118MP0000751_myopathy0.72154321
119MP0009642_abnormal_blood_homeostasis0.72137233
120MP0005171_absent_coat_pigmentation0.71213399
121MP0004147_increased_porphyrin_level0.69480236
122MP0002106_abnormal_muscle_physiology0.68981031
123MP0001984_abnormal_olfaction0.68022924
124MP0000598_abnormal_liver_morphology0.68009544
125MP0005334_abnormal_fat_pad0.67274309
126MP0000639_abnormal_adrenal_gland0.65254276
127MP0002796_impaired_skin_barrier0.65140748
128MP0005620_abnormal_muscle_contractility0.61229432
129MP0000230_abnormal_systemic_arterial0.60411794
130MP0005369_muscle_phenotype0.59718920
131MP0000579_abnormal_nail_morphology0.58669680
132MP0005448_abnormal_energy_balance0.58426859
133MP0005395_other_phenotype0.57869762
134MP0005551_abnormal_eye_electrophysiolog0.56785830
135MP0004233_abnormal_muscle_weight0.56729577
136MP0008469_abnormal_protein_level0.55067341
137MP0004381_abnormal_hair_follicle0.54066804
138MP0000759_abnormal_skeletal_muscle0.53249492
139MP0000462_abnormal_digestive_system0.52061908
140MP0009763_increased_sensitivity_to0.50583304
141MP0003953_abnormal_hormone_level0.50429373
142MP0006082_CNS_inflammation0.48928644
143MP0002295_abnormal_pulmonary_circulatio0.48328426
144MP0009765_abnormal_xenobiotic_induced0.47688895
145MP0009764_decreased_sensitivity_to0.47099247
146MP0006072_abnormal_retinal_apoptosis0.46157732
147MP0002229_neurodegeneration0.45594472
148MP0003950_abnormal_plasma_membrane0.44321534
149MP0003638_abnormal_response/metabolism_0.44313920
150MP0000538_abnormal_urinary_bladder0.41591149
151MP0004185_abnormal_adipocyte_glucose0.40805498

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.77582547
2Intrahepatic cholestasis (HP:0001406)5.17880125
3Prolonged partial thromboplastin time (HP:0003645)4.43388430
4Deep venous thrombosis (HP:0002625)4.25339633
5* Hypobetalipoproteinemia (HP:0003563)4.22806729
6Xanthomatosis (HP:0000991)4.17787726
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.03236454
8Hyperlipoproteinemia (HP:0010980)3.77305530
9Hypothermia (HP:0002045)3.76244166
10Hyperglycinemia (HP:0002154)3.74902667
11Acute encephalopathy (HP:0006846)3.72859093
12Ketosis (HP:0001946)3.71634048
13Cerebral edema (HP:0002181)3.68947012
14Large for gestational age (HP:0001520)3.68685627
15Hyperglycemia (HP:0003074)3.68643879
16Acute necrotizing encephalopathy (HP:0006965)3.53501832
17Hyperammonemia (HP:0001987)3.49445804
18Hypoglycemic coma (HP:0001325)3.47339854
19Abnormality of glycine metabolism (HP:0010895)3.47004429
20Abnormality of serine family amino acid metabolism (HP:0010894)3.47004429
21Abnormality of glycolysis (HP:0004366)3.41250357
22Increased serum pyruvate (HP:0003542)3.41250357
23Abnormal mitochondria in muscle tissue (HP:0008316)3.34742262
24Hepatic necrosis (HP:0002605)3.29234266
25Exercise-induced myalgia (HP:0003738)3.27032710
26Hyperglycinuria (HP:0003108)3.26936221
27Abnormality of methionine metabolism (HP:0010901)3.25723158
28Ketoacidosis (HP:0001993)3.24759243
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.19242120
30Abnormality of fatty-acid metabolism (HP:0004359)3.18737518
31* Hypolipoproteinemia (HP:0010981)3.14783647
32Calf muscle hypertrophy (HP:0008981)3.14763525
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.14234434
34Lethargy (HP:0001254)3.13673793
35Abnormality of vitamin B metabolism (HP:0004340)3.08911260
36Mitochondrial inheritance (HP:0001427)3.04376642
37Hepatocellular necrosis (HP:0001404)2.95405539
38Conjugated hyperbilirubinemia (HP:0002908)2.93237909
39* Fat malabsorption (HP:0002630)2.92771492
40Abnormality of dicarboxylic acid metabolism (HP:0010995)2.91497098
41Dicarboxylic aciduria (HP:0003215)2.91497098
42Progressive macrocephaly (HP:0004481)2.91066682
43* Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.88302044
44Abnormality of the renal cortex (HP:0011035)2.88215598
45Complement deficiency (HP:0004431)2.83682135
46Renal cortical cysts (HP:0000803)2.81944361
47Hypoalphalipoproteinemia (HP:0003233)2.80965669
48Pancreatic cysts (HP:0001737)2.80695004
49Hyperventilation (HP:0002883)2.74842184
50Increased CSF lactate (HP:0002490)2.74825078
51Abnormality of serum amino acid levels (HP:0003112)2.74820296
52Myoglobinuria (HP:0002913)2.74599094
53Abnormality of sulfur amino acid metabolism (HP:0004339)2.74254414
54Metabolic acidosis (HP:0001942)2.71044703
55Epidermoid cyst (HP:0200040)2.66385319
56Gaze-evoked nystagmus (HP:0000640)2.65581674
57Pancreatic fibrosis (HP:0100732)2.60130073
58Insulin-resistant diabetes mellitus (HP:0000831)2.59159689
59Abnormality of the common coagulation pathway (HP:0010990)2.57093717
60Generalized aminoaciduria (HP:0002909)2.55439623
61Abnormality of urine glucose concentration (HP:0011016)2.55417850
62Glycosuria (HP:0003076)2.55417850
63Gout (HP:0001997)2.53914229
64Hemiparesis (HP:0001269)2.52713481
65Fair hair (HP:0002286)2.52554176
66Abnormality of endocrine pancreas physiology (HP:0012093)2.52362718
67Abnormality of the pancreatic islet cells (HP:0006476)2.52362718
68Abnormality of midbrain morphology (HP:0002418)2.52020463
69Molar tooth sign on MRI (HP:0002419)2.52020463
70Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51678270
71Joint hemorrhage (HP:0005261)2.51569931
72Symptomatic seizures (HP:0011145)2.51481467
73Medial flaring of the eyebrow (HP:0010747)2.51058469
74Lactic acidosis (HP:0003128)2.48751289
75Hyperbilirubinemia (HP:0002904)2.48579354
76Renal Fanconi syndrome (HP:0001994)2.48458337
77Abnormality of the intrinsic pathway (HP:0010989)2.44651785
78Lipid accumulation in hepatocytes (HP:0006561)2.43798007
79Abnormal gallbladder morphology (HP:0012437)2.42645321
80Muscle fiber inclusion bodies (HP:0100299)2.41484968
81Late onset (HP:0003584)2.40106630
82Methylmalonic acidemia (HP:0002912)2.37110015
83Methylmalonic aciduria (HP:0012120)2.35455843
84* Vomiting (HP:0002013)2.32095222
85Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.31396222
86Brushfield spots (HP:0001088)2.29407630
87Increased muscle lipid content (HP:0009058)2.29317481
88Delayed CNS myelination (HP:0002188)2.28752654
89Nemaline bodies (HP:0003798)2.28568664
90Hamartoma of the eye (HP:0010568)2.27487700
91Intestinal atresia (HP:0011100)2.26669082
92Abnormality of purine metabolism (HP:0004352)2.25947852
93Abnormality of the vitamin B12 metabolism (HP:0004341)2.25453494
94Exercise-induced muscle cramps (HP:0003710)2.24477527
95Hyperinsulinemic hypoglycemia (HP:0000825)2.24044818
96Increased intramyocellular lipid droplets (HP:0012240)2.23537626
97Furrowed tongue (HP:0000221)2.22284850
98* Steatorrhea (HP:0002570)2.21403390
99Hypomagnesemia (HP:0002917)2.21223698
100True hermaphroditism (HP:0010459)2.21069114
101Muscle hypertrophy of the lower extremities (HP:0008968)2.19941112
102Cholecystitis (HP:0001082)2.19765415
103Abnormal gallbladder physiology (HP:0012438)2.19765415
104Tongue fasciculations (HP:0001308)2.19723093
105EEG with generalized epileptiform discharges (HP:0011198)2.19432178
106CNS demyelination (HP:0007305)2.19107198
107Opisthotonus (HP:0002179)2.18933726
108Congenital stationary night blindness (HP:0007642)2.18550738
109Pancreatic islet-cell hyperplasia (HP:0004510)2.18472518
110Parakeratosis (HP:0001036)2.18324708
111Rhabdomyolysis (HP:0003201)2.18131474
112Irritability (HP:0000737)2.17155211
113Cholelithiasis (HP:0001081)2.16926375
114Conjunctival hamartoma (HP:0100780)2.13932228
115Epileptiform EEG discharges (HP:0011182)2.13090921
116Increased hepatocellular lipid droplets (HP:0006565)2.11417742
117Hypoglycemic seizures (HP:0002173)2.11352849
118Hypsarrhythmia (HP:0002521)2.11162721
119Generalized hypopigmentation of hair (HP:0011358)2.10473595
120Respiratory failure (HP:0002878)2.09292948
121Abnormality of nucleobase metabolism (HP:0010932)2.04191019
122Hydroxyprolinuria (HP:0003080)2.02030590
123Abnormality of proline metabolism (HP:0010907)2.02030590
124Abnormality of vitamin metabolism (HP:0100508)2.01640613
125Hypercholesterolemia (HP:0003124)2.01339793
126Nephronophthisis (HP:0000090)2.00504482
127Congenital sensorineural hearing impairment (HP:0008527)2.00096715
128Febrile seizures (HP:0002373)2.00057202
129Hypochromic microcytic anemia (HP:0004840)1.97957323
130Leukodystrophy (HP:0002415)1.97670634
131Proximal tubulopathy (HP:0000114)1.96561859
132Increased serum lactate (HP:0002151)1.96294424
133Decreased circulating renin level (HP:0003351)1.95931182
134Acute hepatic failure (HP:0006554)1.95451433
135Exercise intolerance (HP:0003546)1.94828261
136Spastic paraparesis (HP:0002313)1.94610667
137Hyperphosphaturia (HP:0003109)1.94598324
138Vascular calcification (HP:0004934)1.94017550
139Chronic hepatic failure (HP:0100626)1.93667075
140Abnormal drinking behavior (HP:0030082)1.93047741
141Polydipsia (HP:0001959)1.93047741
142Muscle stiffness (HP:0003552)1.92556270
1433-Methylglutaconic aciduria (HP:0003535)1.91645983
144Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88569297
145Spontaneous abortion (HP:0005268)1.88540518
146Abnormal pancreas size (HP:0012094)1.87907176
147Congenital primary aphakia (HP:0007707)1.85422609
148Metaphyseal dysplasia (HP:0100255)1.84660964
149Abnormality of alanine metabolism (HP:0010916)1.83570581
150Hyperalaninemia (HP:0003348)1.83570581
151Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83570581
152Thyroiditis (HP:0100646)1.82450913
153Abnormality of the renal medulla (HP:0100957)1.82283114
154Gait imbalance (HP:0002141)1.81790904
155Muscular hypotonia of the trunk (HP:0008936)1.80960742
156Tubular atrophy (HP:0000092)1.80850895
157Progressive inability to walk (HP:0002505)1.79756540
158Enlarged penis (HP:0000040)1.77590940
159Aplasia/Hypoplasia of the fovea (HP:0008060)1.76952149
160Hypoplasia of the fovea (HP:0007750)1.76952149
161Muscle fibrillation (HP:0010546)1.76606907
162Severe muscular hypotonia (HP:0006829)1.75645794
163Delayed gross motor development (HP:0002194)1.75184064
164Abnormality of the calf musculature (HP:0001430)1.74996295
165Type II lissencephaly (HP:0007260)1.74552910
166Neoplasm of the adrenal cortex (HP:0100641)1.71342709
167Broad-based gait (HP:0002136)1.70716066
168Abnormal biliary tract morphology (HP:0012440)1.69814049
169Hypokinesia (HP:0002375)1.69684663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.03797949
2OBSCN3.26379603
3PINK13.05005597
4MAPK152.89477431
5NME12.85518497
6STK392.72535902
7PHKG12.56278989
8PHKG22.56278989
9ACVR1B2.44279928
10INSRR2.44021881
11PBK2.29862846
12MAP4K22.29732218
13OXSR12.27264401
14GRK12.21268939
15PIK3CG2.07237042
16AKT32.00451859
17PAK31.88632780
18ERBB41.86401476
19MAP3K61.83038102
20MAP3K111.69497365
21MST41.65127885
22MAP2K41.56059650
23MKNK21.51699794
24STK161.46274763
25ERBB31.45445452
26CAMK2G1.44137041
27BCR1.43958789
28NUAK11.42958214
29WNK41.40749192
30ARAF1.39338934
31FER1.37061336
32MUSK1.35271653
33ICK1.33103743
34MAP3K41.29761488
35FGR1.27635195
36CASK1.26726120
37TRIM281.26387888
38PIM21.20046647
39NTRK31.19937911
40MET1.19448094
41CSNK1G31.17273377
42DAPK21.15478904
43PLK21.15003008
44LIMK11.12444365
45CAMK2B1.12407473
46CSNK1G11.11607625
47TAOK31.09244209
48ABL21.06310154
49MAP3K121.05205356
50ZAK1.04796544
51MST1R1.04020035
52CAMK2D1.03284910
53EPHB11.01924237
54NLK1.01905639
55SIK11.01569370
56FGFR41.00240011
57DDR20.96487640
58FGFR30.95320326
59PIK3CA0.95289709
60STK30.92787730
61MAPK110.92375425
62DYRK20.92029336
63EPHA40.90945572
64GRK70.90535504
65PDK30.90528215
66PDK40.90528215
67MAPK130.89912253
68BRAF0.89874806
69CAMK2A0.88508825
70BRSK20.88380989
71UHMK10.88192593
72MYLK0.87771716
73PKN10.86108963
74PNCK0.86101393
75NME20.80410449
76MAP3K20.79966685
77FRK0.79066460
78PDK20.78062233
79ERN10.77422947
80MAP3K30.75672780
81CSNK1G20.74883747
82PRKCG0.74386354
83PRKD30.74090632
84STK240.73396591
85MAPK120.73371783
86STK38L0.72390606
87TRPM70.71237190
88SGK20.70681584
89DYRK1B0.69924914
90TNIK0.69383737
91MAPKAPK30.68844515
92PRKAA20.67173609
93GSK3A0.67036448
94BMPR20.65216250
95PTK2B0.65041590
96CSK0.64062994
97CSNK1A1L0.63963894
98PLK30.61044092
99PRKACA0.59570070
100EIF2AK30.59332712
101BMPR1B0.57857326
102MAP2K70.57330244
103PRKCQ0.55307634
104WNK30.54483590
105MAPK40.53576667
106PRKAA10.52742210
107CDK190.51074724
108PRKACG0.50977763
109EPHA30.49509369
110MAPKAPK50.49036946
111NEK90.47764884
112PRKCE0.47348017
113NEK10.46775280
114CAMKK20.45676609
115HIPK20.45239334
116CSNK1A10.44795517
117PRKCZ0.43987363
118MAP2K30.43540972
119IRAK10.42721615
120KDR0.41087125
121FGFR20.41009368
122PRKG10.40283559
123CAMK1G0.40097230
124TLK10.40034529
125TTN0.38659779
126MATK0.37503194
127EIF2AK10.36841164
128ADRBK20.36295941
129MAP2K60.35689918
130PRKCI0.35049776
131SGK30.34885172
132SGK4940.34777613
133SGK2230.34777613
134ROCK10.34380075
135ADRBK10.34040529
136DAPK10.33554347
137STK110.33480707
138TNK20.32787491
139BUB10.32578645
140PRKCA0.32547927
141PASK0.32260555
142TIE10.32120589
143CSNK2A10.32064899
144IKBKB0.31262014
145TEC0.30922103
146MAP2K10.30450639
147MARK10.29982496
148CSNK1D0.29356894
149SGK10.27589071
150PRKACB0.27363620
151TGFBR10.25159766

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.38815380
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69857623
3Fatty acid elongation_Homo sapiens_hsa000622.57363491
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50020960
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48252780
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44328087
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36313607
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32094268
9Butanoate metabolism_Homo sapiens_hsa006502.30972259
10Sulfur metabolism_Homo sapiens_hsa009202.30618313
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.29717927
12Propanoate metabolism_Homo sapiens_hsa006402.27867980
13Fatty acid degradation_Homo sapiens_hsa000712.23046063
14Tryptophan metabolism_Homo sapiens_hsa003802.17269983
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11694095
16Arginine biosynthesis_Homo sapiens_hsa002202.11263423
17Peroxisome_Homo sapiens_hsa041462.11140474
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.10620779
19Steroid biosynthesis_Homo sapiens_hsa001002.09137972
20Fatty acid metabolism_Homo sapiens_hsa012122.06520804
21Oxidative phosphorylation_Homo sapiens_hsa001902.03055095
22Histidine metabolism_Homo sapiens_hsa003401.94183063
23Nitrogen metabolism_Homo sapiens_hsa009101.89864737
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.79240826
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76841224
26Complement and coagulation cascades_Homo sapiens_hsa046101.73843910
27Chemical carcinogenesis_Homo sapiens_hsa052041.73751823
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66900703
29Pyruvate metabolism_Homo sapiens_hsa006201.66593260
30Insulin secretion_Homo sapiens_hsa049111.62873612
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.59890286
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.59525602
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58626232
34Parkinsons disease_Homo sapiens_hsa050121.57918052
35beta-Alanine metabolism_Homo sapiens_hsa004101.56745677
36Folate biosynthesis_Homo sapiens_hsa007901.56240490
37Protein export_Homo sapiens_hsa030601.54463008
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50357464
39Retinol metabolism_Homo sapiens_hsa008301.45958266
40Arginine and proline metabolism_Homo sapiens_hsa003301.44958647
41Phenylalanine metabolism_Homo sapiens_hsa003601.44481169
42Tyrosine metabolism_Homo sapiens_hsa003501.37971713
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37013505
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36972720
45PPAR signaling pathway_Homo sapiens_hsa033201.36647117
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34384515
47Starch and sucrose metabolism_Homo sapiens_hsa005001.33999172
48Phototransduction_Homo sapiens_hsa047441.28996285
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.27826090
50Caffeine metabolism_Homo sapiens_hsa002321.25962407
51Carbon metabolism_Homo sapiens_hsa012001.22790351
52Alzheimers disease_Homo sapiens_hsa050101.19590193
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19133829
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16045543
55Vitamin B6 metabolism_Homo sapiens_hsa007501.15960729
56Sulfur relay system_Homo sapiens_hsa041221.15883055
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.14180659
58Biosynthesis of amino acids_Homo sapiens_hsa012301.12840754
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07736409
60Fat digestion and absorption_Homo sapiens_hsa049751.06803220
61Fatty acid biosynthesis_Homo sapiens_hsa000611.03950329
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03192146
63Selenocompound metabolism_Homo sapiens_hsa004501.02948039
64Glutathione metabolism_Homo sapiens_hsa004801.00484585
65Proteasome_Homo sapiens_hsa030501.00176122
66Staphylococcus aureus infection_Homo sapiens_hsa051500.87437001
67Huntingtons disease_Homo sapiens_hsa050160.87021846
68Bile secretion_Homo sapiens_hsa049760.83982435
69ABC transporters_Homo sapiens_hsa020100.83900177
70Metabolic pathways_Homo sapiens_hsa011000.81878462
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78002451
72Vitamin digestion and absorption_Homo sapiens_hsa049770.76513700
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75692118
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72920355
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72835761
76One carbon pool by folate_Homo sapiens_hsa006700.72819759
77Renin secretion_Homo sapiens_hsa049240.68656792
78Ovarian steroidogenesis_Homo sapiens_hsa049130.65312118
79Linoleic acid metabolism_Homo sapiens_hsa005910.65296679
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.59175782
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58219222
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53928190
83Pentose phosphate pathway_Homo sapiens_hsa000300.53180516
84Fructose and mannose metabolism_Homo sapiens_hsa000510.52616428
85Serotonergic synapse_Homo sapiens_hsa047260.51553882
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51466590
87Type II diabetes mellitus_Homo sapiens_hsa049300.50679613
88Cardiac muscle contraction_Homo sapiens_hsa042600.50394316
89Glycerolipid metabolism_Homo sapiens_hsa005610.50001701
90Circadian entrainment_Homo sapiens_hsa047130.47553949
91Pancreatic secretion_Homo sapiens_hsa049720.46574520
92N-Glycan biosynthesis_Homo sapiens_hsa005100.46545351
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46108653
94Galactose metabolism_Homo sapiens_hsa000520.43351573
95Basal transcription factors_Homo sapiens_hsa030220.42980029
96Ether lipid metabolism_Homo sapiens_hsa005650.42821138
97Salivary secretion_Homo sapiens_hsa049700.42250960
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.41290388
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40690157
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40640695
101Amphetamine addiction_Homo sapiens_hsa050310.38974249
102Dorso-ventral axis formation_Homo sapiens_hsa043200.37400085
103Type I diabetes mellitus_Homo sapiens_hsa049400.36853513
104Regulation of autophagy_Homo sapiens_hsa041400.36724152
105Collecting duct acid secretion_Homo sapiens_hsa049660.34969704
106Arachidonic acid metabolism_Homo sapiens_hsa005900.28892615
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.23313113
108Circadian rhythm_Homo sapiens_hsa047100.20944158
109Prion diseases_Homo sapiens_hsa050200.18107186
110Vibrio cholerae infection_Homo sapiens_hsa051100.16238406
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14743773
112Sphingolipid metabolism_Homo sapiens_hsa006000.11599608
113Lysine degradation_Homo sapiens_hsa003100.06501232
114RNA polymerase_Homo sapiens_hsa030200.04351504
115Mineral absorption_Homo sapiens_hsa049780.03854844
116Glucagon signaling pathway_Homo sapiens_hsa049220.03329999
117* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.03230051
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.00205868
119AMPK signaling pathway_Homo sapiens_hsa04152-0.0725982
120Insulin resistance_Homo sapiens_hsa04931-0.0661794
121SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.0274823
122Lysosome_Homo sapiens_hsa04142-0.0207590

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