SAP18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.50450390
2proteasome assembly (GO:0043248)5.20269669
3viral transcription (GO:0019083)5.14428355
4translational termination (GO:0006415)5.03550703
5ribosomal large subunit biogenesis (GO:0042273)4.96010936
6transcription elongation from RNA polymerase III promoter (GO:0006385)4.81268404
7termination of RNA polymerase III transcription (GO:0006386)4.81268404
8cotranslational protein targeting to membrane (GO:0006613)4.80511804
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.79949388
10GTP biosynthetic process (GO:0006183)4.76684131
11protein targeting to ER (GO:0045047)4.73879777
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.57975089
13protein neddylation (GO:0045116)4.51304357
14protein localization to endoplasmic reticulum (GO:0070972)4.49858371
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.49280755
16cullin deneddylation (GO:0010388)4.40752742
17maturation of SSU-rRNA (GO:0030490)4.21534736
18cellular protein complex disassembly (GO:0043624)4.13464394
19protein complex biogenesis (GO:0070271)4.11661086
20translational elongation (GO:0006414)4.10330817
21protein deneddylation (GO:0000338)4.03650600
227-methylguanosine mRNA capping (GO:0006370)4.02386675
23viral life cycle (GO:0019058)4.01534413
24RNA capping (GO:0036260)3.99974766
257-methylguanosine RNA capping (GO:0009452)3.99974766
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.97756766
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.97756766
28NADH dehydrogenase complex assembly (GO:0010257)3.97756766
29UTP biosynthetic process (GO:0006228)3.91023276
30translation (GO:0006412)3.86117486
31chaperone-mediated protein transport (GO:0072321)3.84079029
32DNA deamination (GO:0045006)3.80988479
33L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.79783791
34oxidative phosphorylation (GO:0006119)3.76817602
35ATP synthesis coupled proton transport (GO:0015986)3.76331121
36energy coupled proton transport, down electrochemical gradient (GO:0015985)3.76331121
37translational initiation (GO:0006413)3.75060484
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.74577101
39respiratory electron transport chain (GO:0022904)3.68900389
40guanosine-containing compound biosynthetic process (GO:1901070)3.67428800
41ribonucleoprotein complex biogenesis (GO:0022613)3.67001970
42water-soluble vitamin biosynthetic process (GO:0042364)3.64634619
43mitochondrial respiratory chain complex assembly (GO:0033108)3.64197589
44ribosomal small subunit assembly (GO:0000028)3.62977807
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.62285226
46hydrogen ion transmembrane transport (GO:1902600)3.62182127
47protein localization to mitochondrion (GO:0070585)3.60397222
48electron transport chain (GO:0022900)3.59300209
49protein-cofactor linkage (GO:0018065)3.58545535
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58290076
51DNA damage response, detection of DNA damage (GO:0042769)3.54637288
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.53613018
53cellular component biogenesis (GO:0044085)3.51678892
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.51504961
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.50234522
56signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.50234522
57signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.50234522
58rRNA modification (GO:0000154)3.49525126
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49156251
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.48214515
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.48214515
62purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.46786195
63ATP biosynthetic process (GO:0006754)3.46496168
64short-term memory (GO:0007614)3.45290004
65spliceosomal snRNP assembly (GO:0000387)3.44895867
66deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.43465941
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.41579515
68regulation of mitochondrial translation (GO:0070129)3.36350186
69spliceosomal complex assembly (GO:0000245)3.36036652
70protein complex disassembly (GO:0043241)3.35008573
71signal transduction involved in DNA integrity checkpoint (GO:0072401)3.34581854
72signal transduction involved in DNA damage checkpoint (GO:0072422)3.34581854
73proton transport (GO:0015992)3.31128680
74signal transduction involved in cell cycle checkpoint (GO:0072395)3.30533113
75deoxyribonucleotide biosynthetic process (GO:0009263)3.29516480
76positive regulation of ligase activity (GO:0051351)3.27422430
77CTP biosynthetic process (GO:0006241)3.26464768
78CTP metabolic process (GO:0046036)3.26464768
79macromolecular complex disassembly (GO:0032984)3.24906749
80hydrogen transport (GO:0006818)3.24844947
81pseudouridine synthesis (GO:0001522)3.22915626
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20203806
83peptidyl-histidine modification (GO:0018202)3.15630914
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.15031201
85respiratory chain complex IV assembly (GO:0008535)3.14932325
86mitochondrial transport (GO:0006839)3.13514490
87rRNA processing (GO:0006364)3.12850496
88UTP metabolic process (GO:0046051)3.12511912
89CENP-A containing nucleosome assembly (GO:0034080)3.11761052
90maturation of 5.8S rRNA (GO:0000460)3.11456626
91transcription elongation from RNA polymerase I promoter (GO:0006362)3.10985474
92nucleoside diphosphate phosphorylation (GO:0006165)3.09051329
93protein targeting to membrane (GO:0006612)3.07432860
94termination of RNA polymerase I transcription (GO:0006363)3.04760570
95protein targeting to mitochondrion (GO:0006626)3.03693807
96ribonucleoside triphosphate biosynthetic process (GO:0009201)3.03370243
97establishment of protein localization to mitochondrial membrane (GO:0090151)3.02802788
98transcription elongation from RNA polymerase II promoter (GO:0006368)3.02409510
99rRNA metabolic process (GO:0016072)3.01787047
100pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.01091566
101transcription-coupled nucleotide-excision repair (GO:0006283)3.00098924
102chromatin remodeling at centromere (GO:0031055)2.98829129
103cytochrome complex assembly (GO:0017004)2.97536693
104positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97452280
105pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96309839
106deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.95941416
107regulation of ubiquitin-protein transferase activity (GO:0051438)2.95824155
108transcription from RNA polymerase I promoter (GO:0006360)2.95298244
109antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.93961293
110RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.93815821
111tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.93815821
112regulation of cellular amine metabolic process (GO:0033238)2.93024356
113deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92977281
114DNA replication checkpoint (GO:0000076)2.92739103
115negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92370696
116negative regulation of ligase activity (GO:0051352)2.92370696
117inner mitochondrial membrane organization (GO:0007007)2.91890724
118amino acid salvage (GO:0043102)2.90555033
119L-methionine salvage (GO:0071267)2.90555033
120L-methionine biosynthetic process (GO:0071265)2.90555033
121metallo-sulfur cluster assembly (GO:0031163)2.89976299
122iron-sulfur cluster assembly (GO:0016226)2.89976299
123regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89129095
124intracellular protein transmembrane import (GO:0044743)2.88979832
125regulation of cellular amino acid metabolic process (GO:0006521)2.88819259
126establishment of protein localization to mitochondrion (GO:0072655)2.88484878
127regulation of ligase activity (GO:0051340)2.85922118
128DNA-templated transcription, elongation (GO:0006354)2.85637704
129deoxyribose phosphate biosynthetic process (GO:0046385)2.85436372
1302-deoxyribonucleotide biosynthetic process (GO:0009265)2.85436372
131anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84344834
132nucleoside triphosphate biosynthetic process (GO:0009142)2.84189041
133aerobic respiration (GO:0009060)2.82855266
134mannosylation (GO:0097502)2.81272045
135rRNA methylation (GO:0031167)2.80678503
136signal peptide processing (GO:0006465)2.79602047
137kinetochore assembly (GO:0051382)2.78457960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.84831754
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.14180016
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.06566299
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.65248887
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.58205052
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.49607937
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38855919
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.23906267
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.19292033
10* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.11029600
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04014200
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.82694408
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.81873808
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.75092720
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.68039991
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.59526146
17VDR_23849224_ChIP-Seq_CD4+_Human2.28067341
18ELK1_19687146_ChIP-ChIP_HELA_Human2.25592750
19DCP1A_22483619_ChIP-Seq_HELA_Human2.20944450
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14990226
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08394185
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00950687
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99918361
24TTF2_22483619_ChIP-Seq_HELA_Human1.91570342
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91412969
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90373857
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88012062
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87614046
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.86660565
30FOXP3_21729870_ChIP-Seq_TREG_Human1.86460527
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80050326
32XRN2_22483619_ChIP-Seq_HELA_Human1.79593543
33VDR_22108803_ChIP-Seq_LS180_Human1.79477148
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74653491
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.73735441
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73707479
37ELK1_22589737_ChIP-Seq_MCF10A_Human1.72531839
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68828786
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67886353
40TAF15_26573619_Chip-Seq_HEK293_Human1.67537329
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65869502
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60474199
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59942962
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55196014
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.54133247
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51238175
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48525710
48GBX2_23144817_ChIP-Seq_PC3_Human1.43819712
49* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43508529
50E2F7_22180533_ChIP-Seq_HELA_Human1.43286511
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42064916
52ZNF274_21170338_ChIP-Seq_K562_Hela1.40612770
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40169384
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34500605
55* GABP_19822575_ChIP-Seq_HepG2_Human1.33289511
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31929129
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31381796
58TP53_22573176_ChIP-Seq_HFKS_Human1.31053284
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30614859
60FUS_26573619_Chip-Seq_HEK293_Human1.29105796
61MYC_18940864_ChIP-ChIP_HL60_Human1.27463709
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.27153501
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26221380
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25563877
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24507767
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22188620
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21149376
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20876657
69* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20449465
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18942019
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18942019
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18942019
73HTT_18923047_ChIP-ChIP_STHdh_Human1.16392144
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12723494
75ER_23166858_ChIP-Seq_MCF-7_Human1.12626157
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11606438
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09209077
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08503774
79EWS_26573619_Chip-Seq_HEK293_Human1.08056633
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07669618
81EZH2_22144423_ChIP-Seq_EOC_Human1.06510452
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06133785
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03449068
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02058913
85* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02058441
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.01847776
87KDM5A_27292631_Chip-Seq_BREAST_Human0.99558358
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99442371
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98719069
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97802020
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95532682
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94455575
93CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92964259
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91874845
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91397385
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91208976
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89879812
98IGF1R_20145208_ChIP-Seq_DFB_Human0.89447249
99IRF1_19129219_ChIP-ChIP_H3396_Human0.89382371
100* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89037398
101RNF2_27304074_Chip-Seq_NSC_Mouse0.88259822
102CBX2_27304074_Chip-Seq_ESCs_Mouse0.88080650
103* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.87162108
104P53_22387025_ChIP-Seq_ESCs_Mouse0.86684979
105P300_19829295_ChIP-Seq_ESCs_Human0.86577707
106FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85031749
107FOXA1_25329375_ChIP-Seq_VCAP_Human0.85031749
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85031683
109E2F1_18555785_Chip-Seq_ESCs_Mouse0.84845494
110NANOG_18555785_Chip-Seq_ESCs_Mouse0.84261432
111P300_18555785_Chip-Seq_ESCs_Mouse0.83849497
112SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83152472
113AR_20517297_ChIP-Seq_VCAP_Human0.83103727
114NMYC_18555785_Chip-Seq_ESCs_Mouse0.82897368
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82420932
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82138169
117SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81975774
118ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81881002
119NANOG_19829295_ChIP-Seq_ESCs_Human0.81787670
120SOX2_19829295_ChIP-Seq_ESCs_Human0.81787670
121STAT3_18555785_Chip-Seq_ESCs_Mouse0.81386256
122FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80078842
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79479218
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78679786
125SOX2_18555785_Chip-Seq_ESCs_Mouse0.78516711
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77557708
127* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77349210
128* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76780210
129CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.76720151
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.76717562
131JUN_21703547_ChIP-Seq_K562_Human0.76242368
132* ELF5_23300383_ChIP-Seq_T47D_Human0.75896141
133NCOR_22424771_ChIP-Seq_293T_Human0.75779651
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.75755001

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.88953051
2MP0001986_abnormal_taste_sensitivity4.09520345
3MP0001188_hyperpigmentation3.75321993
4MP0003136_yellow_coat_color3.66420613
5MP0006036_abnormal_mitochondrial_physio3.09001267
6MP0003806_abnormal_nucleotide_metabolis3.07596801
7MP0006292_abnormal_olfactory_placode3.07219823
8MP0003880_abnormal_central_pattern2.63767845
9MP0003011_delayed_dark_adaptation2.36705242
10MP0002837_dystrophic_cardiac_calcinosis2.36470412
11MP0003941_abnormal_skin_development2.30660416
12MP0003693_abnormal_embryo_hatching2.17716754
13MP0003787_abnormal_imprinting2.15904788
14MP0008932_abnormal_embryonic_tissue2.14399590
15MP0006276_abnormal_autonomic_nervous2.13879923
16MP0005423_abnormal_somatic_nervous2.13695046
17MP0008875_abnormal_xenobiotic_pharmacok2.09518349
18MP0003724_increased_susceptibility_to2.07325464
19MP0000566_synostosis2.02075320
20MP0005409_darkened_coat_color2.01814240
21MP0000372_irregular_coat_pigmentation1.98400466
22MP0006035_abnormal_mitochondrial_morpho1.94528062
23MP0002277_abnormal_respiratory_mucosa1.88909907
24MP0004147_increased_porphyrin_level1.84706996
25MP0002163_abnormal_gland_morphology1.78019659
26MP0001529_abnormal_vocalization1.77546202
27MP0001968_abnormal_touch/_nociception1.74238880
28MP0008058_abnormal_DNA_repair1.65031915
29MP0002638_abnormal_pupillary_reflex1.63513991
30MP0004142_abnormal_muscle_tone1.63135189
31MP0008872_abnormal_physiological_respon1.62235964
32MP0004957_abnormal_blastocyst_morpholog1.61095851
33MP0001764_abnormal_homeostasis1.59585027
34MP0001905_abnormal_dopamine_level1.57312703
35MP0002736_abnormal_nociception_after1.55159616
36MP0008789_abnormal_olfactory_epithelium1.54204507
37MP0003786_premature_aging1.52271018
38MP0002160_abnormal_reproductive_system1.51538811
39MP0003718_maternal_effect1.50861724
40MP0008877_abnormal_DNA_methylation1.45824830
41MP0002751_abnormal_autonomic_nervous1.40806626
42MP0005171_absent_coat_pigmentation1.39951017
43MP0005379_endocrine/exocrine_gland_phen1.35822525
44MP0009250_abnormal_appendicular_skeleto1.35816994
45MP0000049_abnormal_middle_ear1.35011500
46MP0001542_abnormal_bone_strength1.33942785
47MP0002132_abnormal_respiratory_system1.32404043
48MP0002734_abnormal_mechanical_nocicepti1.30197135
49MP0004381_abnormal_hair_follicle1.28804013
50MP0006072_abnormal_retinal_apoptosis1.28795182
51MP0003195_calcinosis1.28666481
52MP0000015_abnormal_ear_pigmentation1.26429518
53MP0003938_abnormal_ear_development1.24999231
54MP0002102_abnormal_ear_morphology1.22674082
55MP0002653_abnormal_ependyma_morphology1.22621223
56MP0002177_abnormal_outer_ear1.22199454
57MP0001919_abnormal_reproductive_system1.21903197
58MP0003121_genomic_imprinting1.20849425
59MP0008007_abnormal_cellular_replicative1.19886763
60MP0002735_abnormal_chemical_nociception1.19447291
61MP0005075_abnormal_melanosome_morpholog1.19303618
62MP0004215_abnormal_myocardial_fiber1.18986550
63MP0008057_abnormal_DNA_replication1.18658840
64MP0005636_abnormal_mineral_homeostasis1.18268904
65MP0003646_muscle_fatigue1.16340340
66MP0005389_reproductive_system_phenotype1.15795294
67MP0010386_abnormal_urinary_bladder1.15322749
68MP0005394_taste/olfaction_phenotype1.15288068
69MP0005499_abnormal_olfactory_system1.15288068
70MP0005332_abnormal_amino_acid1.14947105
71MP0005671_abnormal_response_to1.12779993
72MP0008260_abnormal_autophagy1.11773613
73MP0009697_abnormal_copulation1.11689660
74MP0005410_abnormal_fertilization1.11062118
75MP0003315_abnormal_perineum_morphology1.10408281
76MP0002938_white_spotting1.09625602
77MP0000631_abnormal_neuroendocrine_gland1.09083538
78MP0008995_early_reproductive_senescence1.08066545
79MP0004742_abnormal_vestibular_system1.07886197
80MP0000681_abnormal_thyroid_gland1.05624101
81MP0005084_abnormal_gallbladder_morpholo1.04681957
82MP0002909_abnormal_adrenal_gland1.01158121
83MP0000358_abnormal_cell_content/0.99961369
84MP0002876_abnormal_thyroid_physiology0.99768461
85MP0002095_abnormal_skin_pigmentation0.99565740
86MP0008004_abnormal_stomach_pH0.98778522
87MP0005646_abnormal_pituitary_gland0.97451670
88MP0002090_abnormal_vision0.97294953
89MP0001984_abnormal_olfaction0.95405066
90MP0002210_abnormal_sex_determination0.95232321
91MP0010094_abnormal_chromosome_stability0.94679725
92MP0005645_abnormal_hypothalamus_physiol0.93436223
93MP0001853_heart_inflammation0.92507446
94MP0002272_abnormal_nervous_system0.92482532
95MP0004145_abnormal_muscle_electrophysio0.92320745
96MP0003111_abnormal_nucleus_morphology0.91785261
97MP0001970_abnormal_pain_threshold0.91697603
98MP0000678_abnormal_parathyroid_gland0.91088844
99MP0005408_hypopigmentation0.89746182
100MP0001485_abnormal_pinna_reflex0.88923599
101MP0010030_abnormal_orbit_morphology0.87476004
102MP0000762_abnormal_tongue_morphology0.86964417
103MP0000026_abnormal_inner_ear0.85209476
104MP0002693_abnormal_pancreas_physiology0.85112424
105MP0003755_abnormal_palate_morphology0.84923031
106MP0003077_abnormal_cell_cycle0.82988104
107MP0004133_heterotaxia0.82454092
108MP0009745_abnormal_behavioral_response0.82348634
109MP0003137_abnormal_impulse_conducting0.82231222
110MP0000613_abnormal_salivary_gland0.81880251
111MP0002229_neurodegeneration0.81671449
112MP0002064_seizures0.80906176
113MP0001502_abnormal_circadian_rhythm0.80867104
114MP0001346_abnormal_lacrimal_gland0.80525931
115MP0003123_paternal_imprinting0.79501247
116MP0005551_abnormal_eye_electrophysiolog0.76690228
117MP0000778_abnormal_nervous_system0.76420043
118MP0005257_abnormal_intraocular_pressure0.76283558
119MP0009780_abnormal_chondrocyte_physiolo0.76158835
120MP0002067_abnormal_sensory_capabilities0.75206403
121MP0001727_abnormal_embryo_implantation0.74589890
122MP0001501_abnormal_sleep_pattern0.74024695
123MP0003186_abnormal_redox_activity0.73835194
124MP0008873_increased_physiological_sensi0.73325706
125MP0002148_abnormal_hypersensitivity_rea0.72701347
126MP0002752_abnormal_somatic_nervous0.72565090
127MP0005253_abnormal_eye_physiology0.71915382
128MP0003937_abnormal_limbs/digits/tail_de0.71375263
129MP0004019_abnormal_vitamin_homeostasis0.70908727
130MP0004043_abnormal_pH_regulation0.70620386
131MP0001486_abnormal_startle_reflex0.70143636
132MP0001881_abnormal_mammary_gland0.69836705
133MP0002572_abnormal_emotion/affect_behav0.69380406
134MP0002822_catalepsy0.69031801
135MP0003828_pulmonary_edema0.68251780
136MP0001145_abnormal_male_reproductive0.65660102
137MP0009046_muscle_twitch0.65653890
138MP0004270_analgesia0.65547252
139MP0000653_abnormal_sex_gland0.65414630
140MP0002557_abnormal_social/conspecific_i0.64107321
141MP0001963_abnormal_hearing_physiology0.63958077
142MP0001929_abnormal_gametogenesis0.63434702

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.96327702
2Mitochondrial inheritance (HP:0001427)4.44792465
3Abnormal mitochondria in muscle tissue (HP:0008316)4.37856166
4Progressive macrocephaly (HP:0004481)4.15556083
5Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.00332736
6Hepatocellular necrosis (HP:0001404)3.98802051
7Acute encephalopathy (HP:0006846)3.79622031
8Increased CSF lactate (HP:0002490)3.75545297
9Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.75541384
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.35632929
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.35632929
12Macrocytic anemia (HP:0001972)3.33092544
13Increased hepatocellular lipid droplets (HP:0006565)3.31215610
14Hepatic necrosis (HP:0002605)3.20398219
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.17910838
16Reticulocytopenia (HP:0001896)3.11552890
17Renal Fanconi syndrome (HP:0001994)3.10768201
18Abnormality of cells of the erythroid lineage (HP:0012130)3.10342197
19Progressive external ophthalmoplegia (HP:0000590)3.06769984
20Abnormal hemoglobin (HP:0011902)3.04563742
21Breast hypoplasia (HP:0003187)3.02931024
22Optic disc pallor (HP:0000543)3.02475828
233-Methylglutaconic aciduria (HP:0003535)2.94718419
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.91412894
25Abnormal number of erythroid precursors (HP:0012131)2.90450077
26Exercise intolerance (HP:0003546)2.89548919
27Concave nail (HP:0001598)2.87913152
28Hypothermia (HP:0002045)2.82392995
29Respiratory failure (HP:0002878)2.79650977
30Increased serum lactate (HP:0002151)2.72322644
31Microvesicular hepatic steatosis (HP:0001414)2.66831732
32Lipid accumulation in hepatocytes (HP:0006561)2.66791347
33Methylmalonic acidemia (HP:0002912)2.65667985
34Medial flaring of the eyebrow (HP:0010747)2.63288321
35Lethargy (HP:0001254)2.60837816
36Aplastic anemia (HP:0001915)2.59591686
37Abnormality of the renal collecting system (HP:0004742)2.57051462
38Exertional dyspnea (HP:0002875)2.54925568
39Pallor (HP:0000980)2.52806613
40Methylmalonic aciduria (HP:0012120)2.44930282
41Increased intramyocellular lipid droplets (HP:0012240)2.43047757
42Pancreatic fibrosis (HP:0100732)2.42536280
43True hermaphroditism (HP:0010459)2.41084136
44Molar tooth sign on MRI (HP:0002419)2.41038501
45Abnormality of midbrain morphology (HP:0002418)2.41038501
46Abnormal pupillary function (HP:0007686)2.39734291
47Congenital sensorineural hearing impairment (HP:0008527)2.39192562
48Abnormal hair whorl (HP:0010721)2.39068977
49Aplasia/hypoplasia of the uterus (HP:0008684)2.36100142
50Type I transferrin isoform profile (HP:0003642)2.35325696
51Parakeratosis (HP:0001036)2.35287837
52Duplicated collecting system (HP:0000081)2.35167176
53Birth length less than 3rd percentile (HP:0003561)2.34011041
54Abnormality of urine glucose concentration (HP:0011016)2.30677466
55Glycosuria (HP:0003076)2.30677466
56Congenital primary aphakia (HP:0007707)2.29588957
57Pancreatic cysts (HP:0001737)2.29334564
58Degeneration of anterior horn cells (HP:0002398)2.27593666
59Abnormality of the anterior horn cell (HP:0006802)2.27593666
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26647037
61Abnormality of alanine metabolism (HP:0010916)2.26647037
62Hyperalaninemia (HP:0003348)2.26647037
63Lactic acidosis (HP:0003128)2.25273235
64Gait imbalance (HP:0002141)2.24343512
65Generalized aminoaciduria (HP:0002909)2.22860550
66Dicarboxylic aciduria (HP:0003215)2.22829112
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22829112
68Abnormality of renal resorption (HP:0011038)2.21901560
69Congenital, generalized hypertrichosis (HP:0004540)2.21112557
70Hyperglycinemia (HP:0002154)2.21090684
71Cerebral edema (HP:0002181)2.18795248
72CNS demyelination (HP:0007305)2.17256773
73Triphalangeal thumb (HP:0001199)2.15918524
74Nephrogenic diabetes insipidus (HP:0009806)2.12617508
75Cerebral hypomyelination (HP:0006808)2.06218304
76Abnormality of dental color (HP:0011073)2.03623836
77Hypoglycemic coma (HP:0001325)2.03482782
78Testicular atrophy (HP:0000029)2.03087630
79Rough bone trabeculation (HP:0100670)2.01408765
80Leukodystrophy (HP:0002415)2.00767601
81Abnormal respiratory epithelium morphology (HP:0012253)2.00656001
82Abnormal respiratory motile cilium morphology (HP:0005938)2.00656001
83Pancytopenia (HP:0001876)1.98364041
84X-linked dominant inheritance (HP:0001423)1.97946119
85Adrenal hypoplasia (HP:0000835)1.97773950
86Abnormal protein glycosylation (HP:0012346)1.95793066
87Abnormal glycosylation (HP:0012345)1.95793066
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95793066
89Abnormal protein N-linked glycosylation (HP:0012347)1.95793066
90Conical tooth (HP:0000698)1.94934311
91Emotional lability (HP:0000712)1.94791260
92Myokymia (HP:0002411)1.94023079
93Nasolacrimal duct obstruction (HP:0000579)1.93196556
94Abnormality of glycolysis (HP:0004366)1.92433076
95Increased serum pyruvate (HP:0003542)1.92433076
96Supernumerary spleens (HP:0009799)1.91773293
97Broad-based gait (HP:0002136)1.91514480
98Palpitations (HP:0001962)1.89450536
99Respiratory difficulties (HP:0002880)1.89368731
100Abnormal ciliary motility (HP:0012262)1.89251312
101Abolished electroretinogram (ERG) (HP:0000550)1.88879405
102Progressive microcephaly (HP:0000253)1.87935421
103Renal cortical cysts (HP:0000803)1.85964296
104Submucous cleft hard palate (HP:0000176)1.82901154
105Nephronophthisis (HP:0000090)1.81727346
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80165632
107Secondary amenorrhea (HP:0000869)1.80150636
108Abnormality of serum amino acid levels (HP:0003112)1.79278934
109Hyperglycinuria (HP:0003108)1.78635491
110Abnormality of placental membranes (HP:0011409)1.78529579
111Amniotic constriction ring (HP:0009775)1.78529579
112Multiple enchondromatosis (HP:0005701)1.76931897
113Abnormal rod and cone electroretinograms (HP:0008323)1.75788706
114Sensory axonal neuropathy (HP:0003390)1.75514636
115Abnormality of the labia minora (HP:0012880)1.75383168
116Septo-optic dysplasia (HP:0100842)1.74940921
117IgG deficiency (HP:0004315)1.74777345
118Sleep apnea (HP:0010535)1.74534471
119Abnormal respiratory motile cilium physiology (HP:0012261)1.74345061
120Vaginal atresia (HP:0000148)1.74087933
121Genital tract atresia (HP:0001827)1.72672727
122Horseshoe kidney (HP:0000085)1.72091594
123Aplasia/Hypoplasia of the lens (HP:0008063)1.72072220
124Atrophy/Degeneration involving motor neurons (HP:0007373)1.71825152
125Anencephaly (HP:0002323)1.71761228
126Increased muscle lipid content (HP:0009058)1.71361843
127Poor suck (HP:0002033)1.70756028
128Abnormality of glycine metabolism (HP:0010895)1.70523923
129Abnormality of serine family amino acid metabolism (HP:0010894)1.70523923
130Congenital ichthyosiform erythroderma (HP:0007431)1.69799848
131Depressed nasal ridge (HP:0000457)1.67391852
132Sclerocornea (HP:0000647)1.67253853
133CNS hypomyelination (HP:0003429)1.67162910
134Abnormality of aromatic amino acid family metabolism (HP:0004338)1.67125742
135Attenuation of retinal blood vessels (HP:0007843)1.66950051
136Opisthotonus (HP:0002179)1.66368924
137Cleft eyelid (HP:0000625)1.66122685
138Hyperphosphaturia (HP:0003109)1.65225526
139Metabolic acidosis (HP:0001942)1.64806214
140Optic nerve hypoplasia (HP:0000609)1.64804735
141Aganglionic megacolon (HP:0002251)1.64225575
142Abnormality of the preputium (HP:0100587)1.64145572
143Preaxial hand polydactyly (HP:0001177)1.63831651
144Congenital stationary night blindness (HP:0007642)1.63508152
145Hyperinsulinemic hypoglycemia (HP:0000825)1.63409020
146Limb dystonia (HP:0002451)1.63308393
147Abnormality of the axillary hair (HP:0100134)1.61042678
148Abnormality of secondary sexual hair (HP:0009888)1.61042678
149Aplasia/Hypoplasia of the tongue (HP:0010295)1.60562135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.14664368
2VRK23.63718500
3TLK13.57710423
4EIF2AK13.50671052
5STK162.98606318
6BUB12.88903578
7MKNK22.59061210
8NME22.57733105
9IRAK32.41862020
10BCKDK2.26300010
11SRPK12.21478791
12MAP4K22.14622549
13EIF2AK32.07573014
14MKNK11.94492559
15TESK21.90135276
16NME11.86732491
17MST41.81981746
18VRK11.80894326
19PBK1.79603904
20NEK11.68276247
21WEE11.65812875
22MAP3K121.64155208
23PIM21.61935093
24BMPR1B1.60629201
25TRIM281.59411236
26MAP2K71.58045584
27TNIK1.50072592
28IRAK41.49088541
29CDK191.46652490
30IRAK21.43079982
31FES1.41020346
32PLK41.39336672
33CDK81.36902728
34IRAK11.35024109
35WNK31.33643938
36PDK21.26063354
37BRAF1.25052089
38AKT31.24600824
39ZAK1.19419008
40KDR1.18616662
41ERBB31.18478602
42LIMK11.16993472
43EIF2AK21.12265403
44CSNK1G21.10467815
45PHKG11.05271826
46PHKG21.05271826
47CSNK1G11.03957896
48SCYL21.03638485
49DAPK11.00595713
50DYRK21.00060071
51AURKA0.98446076
52STK390.98299447
53PRPF4B0.95921290
54NEK90.92732539
55ARAF0.92386408
56FRK0.91160348
57BMPR20.90617843
58MAPKAPK50.90183630
59BCR0.86856826
60CSNK1A1L0.86586001
61PINK10.85619954
62TSSK60.84856154
63OXSR10.83795395
64PLK30.83435967
65PLK20.82829610
66DYRK30.81445546
67CDK30.80890452
68GRK70.79048793
69ADRBK20.78726521
70YES10.78693968
71PLK10.78571285
72MUSK0.78037180
73MAPKAPK30.76240519
74NEK60.75481038
75GRK50.74155378
76CLK10.73543893
77NLK0.71550321
78CCNB10.71076655
79CAMK2B0.70985451
80CAMK2D0.68036192
81INSRR0.67842156
82TEC0.65905208
83ADRBK10.64566634
84BLK0.63310885
85PAK30.61872462
86FER0.60676646
87TESK10.60294332
88ABL20.59988012
89MINK10.58990650
90CSNK2A10.58517501
91MAPK130.56097841
92CAMK2A0.54705664
93STK38L0.54336614
94RPS6KA50.54022155
95MARK10.53414145
96OBSCN0.53287853
97WNK40.51555883
98CDC70.51549597
99PNCK0.50969454
100MAP2K60.50827874
101ILK0.50512355
102ACVR1B0.50068838
103TAF10.49654541
104MAPK150.49354110
105MYLK0.48052659
106AURKB0.47785364
107BRSK10.47600646
108CSNK2A20.47394055
109PRKCE0.47361286
110CAMK2G0.46835087
111PRKCI0.45308081
112TAOK30.43097906
113IKBKB0.43086687
114ATR0.42938562
115BRSK20.42765251
116TTK0.42648205
117CSNK1A10.42297828
118NUAK10.42182491
119DAPK30.42151170
120CDK140.40362088
121CHEK20.40169575
122PRKCG0.39644363
123RPS6KA40.39314421
124DYRK1A0.36587703
125TXK0.36456888
126MAP3K40.35486303
127CDK70.35294381
128TIE10.34459531
129CDK90.33767760
130CSNK1G30.33090539
131UHMK10.32918167
132GRK10.29939644

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.27547648
2Oxidative phosphorylation_Homo sapiens_hsa001904.09786520
3RNA polymerase_Homo sapiens_hsa030204.02469294
4Protein export_Homo sapiens_hsa030603.75727087
5Proteasome_Homo sapiens_hsa030503.49288536
6Parkinsons disease_Homo sapiens_hsa050123.27895963
7Huntingtons disease_Homo sapiens_hsa050162.68512318
8Homologous recombination_Homo sapiens_hsa034402.42030504
9Alzheimers disease_Homo sapiens_hsa050102.36149515
10DNA replication_Homo sapiens_hsa030302.35124560
11Pyrimidine metabolism_Homo sapiens_hsa002402.34861805
12Basal transcription factors_Homo sapiens_hsa030222.34447251
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26608426
14Spliceosome_Homo sapiens_hsa030402.21226161
15Mismatch repair_Homo sapiens_hsa034302.18839837
16Fanconi anemia pathway_Homo sapiens_hsa034602.07667472
17Nucleotide excision repair_Homo sapiens_hsa034202.03659132
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.88676547
19Phototransduction_Homo sapiens_hsa047441.61817316
20Collecting duct acid secretion_Homo sapiens_hsa049661.61265711
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51700479
22Purine metabolism_Homo sapiens_hsa002301.48170106
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46401564
24Propanoate metabolism_Homo sapiens_hsa006401.44735036
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41449825
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35927071
27Vibrio cholerae infection_Homo sapiens_hsa051101.30094857
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28511617
29Base excision repair_Homo sapiens_hsa034101.27977732
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24962917
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21430686
32* RNA transport_Homo sapiens_hsa030131.20272186
33Cell cycle_Homo sapiens_hsa041101.08217759
34RNA degradation_Homo sapiens_hsa030181.07545602
35Cardiac muscle contraction_Homo sapiens_hsa042601.06284788
36Non-homologous end-joining_Homo sapiens_hsa034501.06251371
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04073876
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.03427507
39Peroxisome_Homo sapiens_hsa041460.97455675
40Sulfur relay system_Homo sapiens_hsa041220.95507367
41Butanoate metabolism_Homo sapiens_hsa006500.92700816
42Sphingolipid metabolism_Homo sapiens_hsa006000.89234264
43Arachidonic acid metabolism_Homo sapiens_hsa005900.89128901
44Folate biosynthesis_Homo sapiens_hsa007900.87315783
45Pyruvate metabolism_Homo sapiens_hsa006200.86679960
46Rheumatoid arthritis_Homo sapiens_hsa053230.86576944
47One carbon pool by folate_Homo sapiens_hsa006700.84723732
48Nicotine addiction_Homo sapiens_hsa050330.80904397
49Epstein-Barr virus infection_Homo sapiens_hsa051690.79389078
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78987482
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77839337
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75814764
53Regulation of autophagy_Homo sapiens_hsa041400.75576825
54Tryptophan metabolism_Homo sapiens_hsa003800.75351851
55Vitamin B6 metabolism_Homo sapiens_hsa007500.75247075
56Caffeine metabolism_Homo sapiens_hsa002320.73447532
57Synaptic vesicle cycle_Homo sapiens_hsa047210.68021171
58Primary immunodeficiency_Homo sapiens_hsa053400.64999498
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64494153
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.64408836
61Nitrogen metabolism_Homo sapiens_hsa009100.63795206
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62160665
63Glutathione metabolism_Homo sapiens_hsa004800.62114553
64Ether lipid metabolism_Homo sapiens_hsa005650.61870829
65Chemical carcinogenesis_Homo sapiens_hsa052040.61759532
66beta-Alanine metabolism_Homo sapiens_hsa004100.61561163
67Metabolic pathways_Homo sapiens_hsa011000.61476034
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60755689
69Serotonergic synapse_Homo sapiens_hsa047260.59862291
70Fatty acid metabolism_Homo sapiens_hsa012120.58316058
71Graft-versus-host disease_Homo sapiens_hsa053320.57486849
72Sulfur metabolism_Homo sapiens_hsa009200.57275541
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57136356
74p53 signaling pathway_Homo sapiens_hsa041150.56179635
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54739464
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54039619
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54002555
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53989583
79Oocyte meiosis_Homo sapiens_hsa041140.53248483
80Carbon metabolism_Homo sapiens_hsa012000.51937946
81Fatty acid degradation_Homo sapiens_hsa000710.50854201
82Linoleic acid metabolism_Homo sapiens_hsa005910.49697783
83Phagosome_Homo sapiens_hsa041450.49356398
84Selenocompound metabolism_Homo sapiens_hsa004500.49009554
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47564714
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46724521
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45188274
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.43748276
89Long-term depression_Homo sapiens_hsa047300.43334072
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.43027231
91Other glycan degradation_Homo sapiens_hsa005110.41839320
92Taste transduction_Homo sapiens_hsa047420.41612223
93Fatty acid elongation_Homo sapiens_hsa000620.38693494
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38692119
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38510165
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38435103
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38193797
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.35529666
99Melanoma_Homo sapiens_hsa052180.34912371
100Systemic lupus erythematosus_Homo sapiens_hsa053220.34282883
101Alcoholism_Homo sapiens_hsa050340.32540152
102* mRNA surveillance pathway_Homo sapiens_hsa030150.31389778
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31365715
104Tyrosine metabolism_Homo sapiens_hsa003500.31303315
105Wnt signaling pathway_Homo sapiens_hsa043100.26028167
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.25981884
107Amphetamine addiction_Homo sapiens_hsa050310.25847237
108Mineral absorption_Homo sapiens_hsa049780.25741321
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25359357
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24364566
111Asthma_Homo sapiens_hsa053100.22382672
112Antigen processing and presentation_Homo sapiens_hsa046120.22020060
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.21208101
114Hematopoietic cell lineage_Homo sapiens_hsa046400.20651600
115Autoimmune thyroid disease_Homo sapiens_hsa053200.20278983
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18311849
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16041967
118Dopaminergic synapse_Homo sapiens_hsa047280.15708599
119TGF-beta signaling pathway_Homo sapiens_hsa043500.15425582
120Type I diabetes mellitus_Homo sapiens_hsa049400.15053909
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15006229
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14569895
123Morphine addiction_Homo sapiens_hsa050320.14014471
124Steroid biosynthesis_Homo sapiens_hsa001000.12723768
125GABAergic synapse_Homo sapiens_hsa047270.12186753
126Allograft rejection_Homo sapiens_hsa053300.12098466
127Retinol metabolism_Homo sapiens_hsa008300.11585579
128N-Glycan biosynthesis_Homo sapiens_hsa005100.11449139
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.09949729
130Herpes simplex infection_Homo sapiens_hsa051680.09066628
131Arginine and proline metabolism_Homo sapiens_hsa003300.08207924
132Ras signaling pathway_Homo sapiens_hsa040140.07174441

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