SAMD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)9.05387552
2detection of light stimulus involved in visual perception (GO:0050908)9.05387552
3phototransduction (GO:0007602)9.04517835
4detection of light stimulus (GO:0009583)8.66574299
5phototransduction, visible light (GO:0007603)8.48025649
6GMP metabolic process (GO:0046037)8.42761973
7visual perception (GO:0007601)8.34155819
8detection of visible light (GO:0009584)8.28590690
9sensory perception of light stimulus (GO:0050953)8.24668685
10eye photoreceptor cell differentiation (GO:0001754)7.99918426
11photoreceptor cell differentiation (GO:0046530)7.99918426
12retina development in camera-type eye (GO:0060041)7.06617126
13protein-chromophore linkage (GO:0018298)6.56200496
14positive regulation of guanylate cyclase activity (GO:0031284)6.28918008
15detection of external stimulus (GO:0009581)6.14671066
16detection of abiotic stimulus (GO:0009582)6.04056690
17cellular response to light stimulus (GO:0071482)5.96049639
18regulation of guanylate cyclase activity (GO:0031282)5.62889104
19peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.21770974
20regulation of clathrin-mediated endocytosis (GO:2000369)5.10127859
21nonmotile primary cilium assembly (GO:0035058)5.07036014
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.95344654
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.80111670
24L-fucose catabolic process (GO:0042355)4.44072669
25fucose catabolic process (GO:0019317)4.44072669
26L-fucose metabolic process (GO:0042354)4.44072669
27regulation of cGMP metabolic process (GO:0030823)4.29276427
28retina layer formation (GO:0010842)4.24772202
29behavioral response to nicotine (GO:0035095)4.24572393
30regulation of short-term neuronal synaptic plasticity (GO:0048172)4.19076584
31water-soluble vitamin biosynthetic process (GO:0042364)4.11817104
32regulation of cilium movement (GO:0003352)4.08999605
33neuron development (GO:0048666)4.06064500
34detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.04045501
35sensory perception (GO:0007600)4.02769419
36negative regulation of mast cell activation (GO:0033004)3.96727559
37response to pheromone (GO:0019236)3.93257237
38cellular response to radiation (GO:0071478)3.84910210
39estrogen biosynthetic process (GO:0006703)3.82464820
40L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.80544630
41positive regulation of cGMP biosynthetic process (GO:0030828)3.78255384
42indole-containing compound catabolic process (GO:0042436)3.73426587
43indolalkylamine catabolic process (GO:0046218)3.73426587
44tryptophan catabolic process (GO:0006569)3.73426587
45kynurenine metabolic process (GO:0070189)3.63446190
46indolalkylamine metabolic process (GO:0006586)3.62375040
47adaptation of signaling pathway (GO:0023058)3.58955922
48axoneme assembly (GO:0035082)3.53468975
49neuronal action potential propagation (GO:0019227)3.53326817
50regulation of cGMP biosynthetic process (GO:0030826)3.51830088
51protein polyglutamylation (GO:0018095)3.51530876
52protein localization to synapse (GO:0035418)3.51530196
53regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.48764271
54response to light stimulus (GO:0009416)3.38823303
55L-methionine salvage (GO:0071267)3.38164286
56L-methionine biosynthetic process (GO:0071265)3.38164286
57amino acid salvage (GO:0043102)3.38164286
58signal peptide processing (GO:0006465)3.37613983
59auditory receptor cell stereocilium organization (GO:0060088)3.34277950
60limb development (GO:0060173)3.33513826
61appendage development (GO:0048736)3.33513826
62positive regulation of cGMP metabolic process (GO:0030825)3.30462709
63synaptic vesicle maturation (GO:0016188)3.30167779
64negative regulation of receptor-mediated endocytosis (GO:0048261)3.29465406
65positive regulation of vesicle fusion (GO:0031340)3.26259436
66synaptic vesicle docking involved in exocytosis (GO:0016081)3.20844362
67regulation of glucokinase activity (GO:0033131)3.20305614
68regulation of hexokinase activity (GO:1903299)3.20305614
69sodium ion export (GO:0071436)3.19626569
70regulation of memory T cell differentiation (GO:0043380)3.19388554
71regulation of action potential (GO:0098900)3.13828574
72mannosylation (GO:0097502)3.08626039
73platelet dense granule organization (GO:0060155)3.06615169
74protein-cofactor linkage (GO:0018065)3.05554396
75methionine biosynthetic process (GO:0009086)3.04337661
76negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.02633221
77respiratory chain complex IV assembly (GO:0008535)2.99647401
78cellular potassium ion homeostasis (GO:0030007)2.99624625
79S-adenosylmethionine metabolic process (GO:0046500)2.97252144
80DNA deamination (GO:0045006)2.96890258
81righting reflex (GO:0060013)2.93224170
82cellular ketone body metabolic process (GO:0046950)2.92969990
83histone H3-K4 trimethylation (GO:0080182)2.92650213
84positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.92538188
85piRNA metabolic process (GO:0034587)2.91856811
86prenylation (GO:0097354)2.91276024
87protein prenylation (GO:0018342)2.91276024
88DNA double-strand break processing (GO:0000729)2.90845902
89positive regulation of sodium ion transmembrane transport (GO:1902307)2.89356814
90preassembly of GPI anchor in ER membrane (GO:0016254)2.87792573
91tryptophan metabolic process (GO:0006568)2.87277608
92cell morphogenesis involved in neuron differentiation (GO:0048667)2.87154418
93negative regulation of interleukin-1 beta production (GO:0032691)2.83554561
94regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.83105860
95detection of mechanical stimulus involved in sensory perception (GO:0050974)2.82222807
96regulation of voltage-gated calcium channel activity (GO:1901385)2.81584253
97response to nitrosative stress (GO:0051409)2.80893684
98bile acid biosynthetic process (GO:0006699)2.80280087
99neural tube formation (GO:0001841)2.79615804
100male meiosis I (GO:0007141)2.78472900
101somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77545680
102somatic hypermutation of immunoglobulin genes (GO:0016446)2.77545680
103neuronal action potential (GO:0019228)2.77456156
104head development (GO:0060322)2.77036050
105imidazole-containing compound metabolic process (GO:0052803)2.76694984
106cytochrome complex assembly (GO:0017004)2.76218144
107glycine transport (GO:0015816)2.74860005
108adenosine metabolic process (GO:0046085)2.74601958
109membrane hyperpolarization (GO:0060081)2.73571673
110receptor guanylyl cyclase signaling pathway (GO:0007168)2.73418243
111cilium morphogenesis (GO:0060271)2.73293695
112positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.73041930
113detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.71533047
114amine catabolic process (GO:0009310)2.71444053
115cellular biogenic amine catabolic process (GO:0042402)2.71444053
116positive regulation of neurotransmitter transport (GO:0051590)2.71056432
117negative regulation of interleukin-1 production (GO:0032692)2.69945408
118positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69896519
119potassium ion homeostasis (GO:0055075)2.69476459
120inner ear receptor stereocilium organization (GO:0060122)2.65277629
121G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65177238
122protein K11-linked deubiquitination (GO:0035871)2.63397455
123retina homeostasis (GO:0001895)2.62776355
124epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61874515
125positive regulation of glycolytic process (GO:0045821)2.59313719
126ketone body metabolic process (GO:1902224)2.59157297
127protein complex biogenesis (GO:0070271)2.54924945
128nucleotide transmembrane transport (GO:1901679)2.54605763
129positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.54464275
130negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52237978
131glycerophospholipid catabolic process (GO:0046475)2.52165573
132regulation of synaptic vesicle exocytosis (GO:2000300)2.51639895
133regulation of vesicle fusion (GO:0031338)2.51187758
134regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.50289357
135regulation of type B pancreatic cell apoptotic process (GO:2000674)2.49994229
136rRNA catabolic process (GO:0016075)2.49871052
137fatty acid elongation (GO:0030497)2.49527966
138lipoprotein transport (GO:0042953)2.49348476
139methionine metabolic process (GO:0006555)2.48842001
140synaptic vesicle exocytosis (GO:0016079)2.48174682
141chemosensory behavior (GO:0007635)2.47841523
142sterol catabolic process (GO:0016127)2.45773579
143cholesterol catabolic process (GO:0006707)2.45773579
144negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.45216397
145nephron tubule morphogenesis (GO:0072078)2.44929263
146nephron epithelium morphogenesis (GO:0072088)2.44929263
147oxidative demethylation (GO:0070989)2.44492187
148indole-containing compound metabolic process (GO:0042430)2.44117410
149behavioral response to ethanol (GO:0048149)2.43660029
150benzene-containing compound metabolic process (GO:0042537)2.43595790
151negative regulation of synaptic transmission, GABAergic (GO:0032229)2.43391208
152CDP-diacylglycerol biosynthetic process (GO:0016024)2.42663200
153multicellular organism reproduction (GO:0032504)2.42416412
154gamma-aminobutyric acid transport (GO:0015812)2.41442044
155regulation of MHC class II biosynthetic process (GO:0045346)2.40294592
156negative regulation of cytosolic calcium ion concentration (GO:0051481)2.40180065
157GPI anchor metabolic process (GO:0006505)2.39426983
158replication fork processing (GO:0031297)2.39286632
159positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.39244419
160cilium organization (GO:0044782)2.38551402
161retinoid metabolic process (GO:0001523)2.38400365
162startle response (GO:0001964)2.35879851
163protein localization to cilium (GO:0061512)2.35240381
164positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.32528257
165response to radiation (GO:0009314)2.30344599
166apical protein localization (GO:0045176)2.29832998
167phospholipid translocation (GO:0045332)2.29256167
168lipid translocation (GO:0034204)2.29256167
169lactate metabolic process (GO:0006089)2.25515708
170glutamate secretion (GO:0014047)2.25317613
171regulation of synaptic vesicle transport (GO:1902803)2.24514366
172diterpenoid metabolic process (GO:0016101)2.23608320
173potassium ion import (GO:0010107)2.22942859
174neuron remodeling (GO:0016322)2.22267780
175positive regulation of neurotransmitter secretion (GO:0001956)2.21932142
176cytoplasmic mRNA processing body assembly (GO:0033962)2.21700444
177calcium ion import (GO:0070509)2.19419625
178regulation of rhodopsin mediated signaling pathway (GO:0022400)13.9003157
179rhodopsin mediated signaling pathway (GO:0016056)13.4769268
180photoreceptor cell development (GO:0042461)12.7042026
181retinal cone cell development (GO:0046549)12.4623589
182eye photoreceptor cell development (GO:0042462)12.1363532
183photoreceptor cell maintenance (GO:0045494)12.1253537
184retinal rod cell development (GO:0046548)11.7491544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.56198076
2GBX2_23144817_ChIP-Seq_PC3_Human3.03747001
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.89598671
4EZH2_22144423_ChIP-Seq_EOC_Human2.87991123
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71079771
6CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.58204223
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.21241149
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21188873
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20287464
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09972073
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00578010
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98697865
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97526974
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97028592
15DROSHA_22980978_ChIP-Seq_HELA_Human1.94407346
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.93329429
17VDR_22108803_ChIP-Seq_LS180_Human1.92177370
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91930448
19FUS_26573619_Chip-Seq_HEK293_Human1.91883709
20EWS_26573619_Chip-Seq_HEK293_Human1.86061940
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82978548
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82978548
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82700530
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.80747301
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.80467573
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.79832709
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77798590
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75365395
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74335981
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72231628
31REST_21632747_ChIP-Seq_MESCs_Mouse1.71864040
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70860458
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70766341
34* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69250496
35P53_22127205_ChIP-Seq_FIBROBLAST_Human1.69157546
36IRF1_19129219_ChIP-ChIP_H3396_Human1.69001786
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67175491
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65890223
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.64995826
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64501097
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64452396
42TAF15_26573619_Chip-Seq_HEK293_Human1.62335681
43IGF1R_20145208_ChIP-Seq_DFB_Human1.61537426
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58320420
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58247465
46TP53_22573176_ChIP-Seq_HFKS_Human1.54068302
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51924278
48SMAD4_21799915_ChIP-Seq_A2780_Human1.51724222
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.51561867
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49814844
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.48543177
52FLI1_21867929_ChIP-Seq_TH2_Mouse1.47436279
53TCF4_22108803_ChIP-Seq_LS180_Human1.44620058
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44235802
55AR_21572438_ChIP-Seq_LNCaP_Human1.43142039
56TBL1_22424771_ChIP-Seq_293T_Human1.43010104
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42868317
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.42777833
59SOX2_19829295_ChIP-Seq_ESCs_Human1.42043626
60NANOG_19829295_ChIP-Seq_ESCs_Human1.42043626
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41050813
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.40827350
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.40342887
64SMAD3_21741376_ChIP-Seq_HESCs_Human1.40089362
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39749158
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.38809853
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38574922
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36611179
69AR_19668381_ChIP-Seq_PC3_Human1.35401903
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35281221
71TCF4_18268006_ChIP-ChIP_LS174T_Human1.35279476
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35099863
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34475927
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.33614688
75AR_25329375_ChIP-Seq_VCAP_Human1.32968913
76STAT3_23295773_ChIP-Seq_U87_Human1.32722829
77KDM2B_26808549_Chip-Seq_K562_Human1.31771346
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.30571318
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29680051
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29591499
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.29591499
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28838273
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28809384
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28709721
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28709721
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.27454970
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.27422767
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25754240
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25171198
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25149803
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24892185
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.24495670
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24413810
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24308920
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23739459
96RNF2_27304074_Chip-Seq_NSC_Mouse1.23646175
97RUNX2_22187159_ChIP-Seq_PCA_Human1.23538290
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23329748
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.23125417
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23085450
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23069702
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22454108
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22290197
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.22162770
105P300_19829295_ChIP-Seq_ESCs_Human1.22113089
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19793827
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18375698
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18368641
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.18201345
110* GATA3_21878914_ChIP-Seq_MCF-7_Human1.17438459
111BCAT_22108803_ChIP-Seq_LS180_Human1.17191164
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16285745
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15901992
114EP300_21415370_ChIP-Seq_HL-1_Mouse1.15179518
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14793597
116ISL1_27105846_Chip-Seq_CPCs_Mouse1.14249988
117CTCF_27219007_Chip-Seq_Bcells_Human1.13158349
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.13100745
119NCOR_22424771_ChIP-Seq_293T_Human1.13027591
120CDX2_22108803_ChIP-Seq_LS180_Human1.11865857
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10305992
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.10156534
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08014141
124GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.07846698
125* TCF4_23295773_ChIP-Seq_U87_Human1.07564394
126SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07522831
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07469423
128MYC_18940864_ChIP-ChIP_HL60_Human1.06882571
129AR_20517297_ChIP-Seq_VCAP_Human1.06823203
130* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06329798
131ELK1_19687146_ChIP-ChIP_HELA_Human1.05693140
132OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05189009
133SMAD_19615063_ChIP-ChIP_OVARY_Human1.04918451
134TAL1_26923725_Chip-Seq_HPCs_Mouse1.04725211
135SMAD3_21741376_ChIP-Seq_EPCs_Human1.03485631
136FOXH1_21741376_ChIP-Seq_EPCs_Human1.03023842
137WDR5_24793694_ChIP-Seq_LNCAP_Human1.02841297
138RING1B_27294783_Chip-Seq_ESCs_Mouse1.02075978
139SMAD3_21741376_ChIP-Seq_ESCs_Human1.01664606
140ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01521261
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01506243
142PRDM14_20953172_ChIP-Seq_ESCs_Human1.01058450
143PIAS1_25552417_ChIP-Seq_VCAP_Human1.00283545
144SMAD4_21741376_ChIP-Seq_HESCs_Human1.00028679
145ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98746289
146GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98242184
147IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97765043
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96804898
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96576296
150ER_23166858_ChIP-Seq_MCF-7_Human0.96170651
151EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95303768
152CBP_20019798_ChIP-Seq_JUKART_Human0.94802027
153IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94802027
154CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94528143
155RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94243458
156GF1_26923725_Chip-Seq_HPCs_Mouse0.94107760
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.92546535
158OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91409539
159SOX2_21211035_ChIP-Seq_LN229_Gbm0.90919131
160KDM2B_26808549_Chip-Seq_REH_Human0.90557865
161GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90189542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.21577148
2MP0003011_delayed_dark_adaptation8.67957306
3MP0006072_abnormal_retinal_apoptosis7.00447081
4MP0005253_abnormal_eye_physiology6.40290706
5MP0005195_abnormal_posterior_eye4.10882626
6MP0001324_abnormal_eye_pigmentation3.49046264
7MP0005391_vision/eye_phenotype3.26399636
8MP0003950_abnormal_plasma_membrane3.23043863
9MP0002653_abnormal_ependyma_morphology3.22239312
10MP0003195_calcinosis2.97233790
11MP0002229_neurodegeneration2.71551159
12MP0002638_abnormal_pupillary_reflex2.67577439
13MP0006292_abnormal_olfactory_placode2.63457638
14MP0005423_abnormal_somatic_nervous2.33906205
15MP0002090_abnormal_vision2.28746194
16MP0002736_abnormal_nociception_after2.25735022
17MP0001502_abnormal_circadian_rhythm2.24844803
18MP0002752_abnormal_somatic_nervous2.19895082
19MP0005645_abnormal_hypothalamus_physiol2.18653897
20MP0004147_increased_porphyrin_level2.13545594
21MP0008872_abnormal_physiological_respon2.09028298
22MP0002876_abnormal_thyroid_physiology1.90061396
23MP0000372_irregular_coat_pigmentation1.83220899
24MP0002254_reproductive_system_inflammat1.81796376
25MP0001873_stomach_inflammation1.75941275
26MP0002735_abnormal_chemical_nociception1.65649450
27MP0004885_abnormal_endolymph1.62447625
28MP0002882_abnormal_neuron_morphology1.61945775
29MP0002163_abnormal_gland_morphology1.55943008
30MP0005394_taste/olfaction_phenotype1.47945747
31MP0005499_abnormal_olfactory_system1.47945747
32MP0005084_abnormal_gallbladder_morpholo1.44835943
33MP0008789_abnormal_olfactory_epithelium1.43819857
34MP0003252_abnormal_bile_duct1.33887155
35MP0005410_abnormal_fertilization1.32801460
36MP0000569_abnormal_digit_pigmentation1.29785858
37MP0005671_abnormal_response_to1.25896418
38MP0001764_abnormal_homeostasis1.24656702
39MP0004270_analgesia1.22757004
40MP0001984_abnormal_olfaction1.21367531
41MP0003880_abnormal_central_pattern1.20453800
42MP0005248_abnormal_Harderian_gland1.20448656
43MP0002733_abnormal_thermal_nociception1.19198763
44MP0000427_abnormal_hair_cycle1.18821177
45MP0010030_abnormal_orbit_morphology1.17853903
46MP0003718_maternal_effect1.16827840
47MP0005379_endocrine/exocrine_gland_phen1.14491217
48MP0008058_abnormal_DNA_repair1.12864534
49MP0001486_abnormal_startle_reflex1.12481513
50MP0005075_abnormal_melanosome_morpholog1.12148134
51MP0002928_abnormal_bile_duct1.11263448
52MP0002837_dystrophic_cardiac_calcinosis1.11091446
53MP0004043_abnormal_pH_regulation1.10643741
54MP0002160_abnormal_reproductive_system1.06229504
55MP0004133_heterotaxia1.06044638
56MP0010329_abnormal_lipoprotein_level1.03803926
57MP0002138_abnormal_hepatobiliary_system1.02215558
58MP0002102_abnormal_ear_morphology1.01953391
59MP0001485_abnormal_pinna_reflex1.01675549
60MP0002938_white_spotting1.01540407
61MP0005365_abnormal_bile_salt0.98980450
62MP0001346_abnormal_lacrimal_gland0.98901199
63MP0005389_reproductive_system_phenotype0.97699198
64MP0005174_abnormal_tail_pigmentation0.97142451
65MP0001986_abnormal_taste_sensitivity0.97070438
66MP0003122_maternal_imprinting0.96566797
67MP0005197_abnormal_uvea_morphology0.96143638
68MP0003283_abnormal_digestive_organ0.95473396
69MP0005187_abnormal_penis_morphology0.93831866
70MP0004859_abnormal_synaptic_plasticity0.93428831
71MP0001529_abnormal_vocalization0.93183358
72MP0006054_spinal_hemorrhage0.92223138
73MP0003121_genomic_imprinting0.89384544
74MP0001919_abnormal_reproductive_system0.89103314
75MP0000383_abnormal_hair_follicle0.88400947
76MP0001286_abnormal_eye_development0.86867767
77MP0002272_abnormal_nervous_system0.86437376
78MP0003634_abnormal_glial_cell0.86071530
79MP0003635_abnormal_synaptic_transmissio0.85607387
80MP0003890_abnormal_embryonic-extraembry0.85422733
81MP0002127_abnormal_cardiovascular_syste0.84344418
82MP0008875_abnormal_xenobiotic_pharmacok0.83751185
83MP0000778_abnormal_nervous_system0.80783939
84MP0005395_other_phenotype0.80674236
85MP0005647_abnormal_sex_gland0.80481993
86MP0002697_abnormal_eye_size0.80109802
87MP0003045_fibrosis0.79321914
88MP0000631_abnormal_neuroendocrine_gland0.79288097
89MP0002693_abnormal_pancreas_physiology0.78569665
90MP0002734_abnormal_mechanical_nocicepti0.77932925
91MP0001119_abnormal_female_reproductive0.77854881
92MP0005448_abnormal_energy_balance0.77568995
93MP0003119_abnormal_digestive_system0.76345234
94MP0002064_seizures0.76245031
95MP0004742_abnormal_vestibular_system0.74747407
96MP0004233_abnormal_muscle_weight0.74471188
97MP0002234_abnormal_pharynx_morphology0.74339817
98MP0001944_abnormal_pancreas_morphology0.73373509
99MP0009046_muscle_twitch0.73321794
100MP0005636_abnormal_mineral_homeostasis0.72655826
101MP0002168_other_aberrant_phenotype0.72415466
102MP0001963_abnormal_hearing_physiology0.69910999
103MP0004019_abnormal_vitamin_homeostasis0.65855033
104MP0002063_abnormal_learning/memory/cond0.64426388
105MP0002067_abnormal_sensory_capabilities0.63796505
106MP0002184_abnormal_innervation0.62533982
107MP0010386_abnormal_urinary_bladder0.59060949
108MP0004782_abnormal_surfactant_physiolog0.57874728
109MP0009745_abnormal_behavioral_response0.57283179
110MP0003787_abnormal_imprinting0.55849182
111MP0002572_abnormal_emotion/affect_behav0.55589351
112MP0001293_anophthalmia0.54845949
113MP0008004_abnormal_stomach_pH0.54653134
114MP0002152_abnormal_brain_morphology0.52449735
115MP0004924_abnormal_behavior0.49852854
116MP0005386_behavior/neurological_phenoty0.49852854
117MP0000026_abnormal_inner_ear0.47735718
118MP0000465_gastrointestinal_hemorrhage0.45294646
119MP0005646_abnormal_pituitary_gland0.45111720
120MP0001968_abnormal_touch/_nociception0.45007195
121MP0003861_abnormal_nervous_system0.44226118
122MP0004145_abnormal_muscle_electrophysio0.43794898
123MP0003698_abnormal_male_reproductive0.43446197
124MP0002332_abnormal_exercise_endurance0.43372539
125MP0003632_abnormal_nervous_system0.42147617
126MP0000955_abnormal_spinal_cord0.42041994
127MP0005193_abnormal_anterior_eye0.39956988
128MP0002557_abnormal_social/conspecific_i0.39108260
129MP0002066_abnormal_motor_capabilities/c0.38949803
130MP0004215_abnormal_myocardial_fiber0.38004363
131MP0008569_lethality_at_weaning0.35410613
132MP0008877_abnormal_DNA_methylation0.34194611
133MP0000579_abnormal_nail_morphology0.33538015
134MP0003646_muscle_fatigue0.33099057
135MP0004811_abnormal_neuron_physiology0.32873010
136MP0001915_intracranial_hemorrhage0.32735667
137MP0003633_abnormal_nervous_system0.32328662
138MP0008961_abnormal_basal_metabolism0.31444642
139MP0004085_abnormal_heartbeat0.30400330
140MP0003631_nervous_system_phenotype0.30229400
141MP0009780_abnormal_chondrocyte_physiolo0.29416935
142MP0002092_abnormal_eye_morphology0.29291465
143MP0001440_abnormal_grooming_behavior0.28151943
144MP0001501_abnormal_sleep_pattern0.27577391
145MP0004142_abnormal_muscle_tone0.27564659
146MP0001929_abnormal_gametogenesis0.25657157
147MP0001970_abnormal_pain_threshold0.25208051
148MP0005257_abnormal_intraocular_pressure0.24010940
149MP0002161_abnormal_fertility/fecundity0.22877321
150MP0006276_abnormal_autonomic_nervous0.22294733
151MP0001177_atelectasis0.20846603
152MP0002069_abnormal_eating/drinking_beha0.20626091

Predicted human phenotypes

RankGene SetZ-score
1Pendular nystagmus (HP:0012043)9.63004799
2Bony spicule pigmentary retinopathy (HP:0007737)9.47354017
3Chorioretinal atrophy (HP:0000533)9.21591471
4Abolished electroretinogram (ERG) (HP:0000550)8.83421570
5Pigmentary retinal degeneration (HP:0001146)8.33559805
6Central scotoma (HP:0000603)8.13193665
7Abnormality of macular pigmentation (HP:0008002)7.03384669
8Dyschromatopsia (HP:0007641)6.93284580
9Decreased central vision (HP:0007663)6.90855092
10Scotoma (HP:0000575)6.85985289
11Severe visual impairment (HP:0001141)6.73937562
12Posterior subcapsular cataract (HP:0007787)6.31895075
13Attenuation of retinal blood vessels (HP:0007843)6.24044710
14Keratoconus (HP:0000563)5.77586556
15Increased corneal curvature (HP:0100692)5.77586556
16Macular degeneration (HP:0000608)5.55489140
17Cone-rod dystrophy (HP:0000548)5.42157538
18Vitreoretinal degeneration (HP:0000655)5.39119894
19Type II diabetes mellitus (HP:0005978)5.22571417
20Photophobia (HP:0000613)5.04815291
21Chronic hepatic failure (HP:0100626)4.64537664
22Constricted visual fields (HP:0001133)4.57180028
23Subcapsular cataract (HP:0000523)3.86853077
24Retinitis pigmentosa (HP:0000510)3.71701297
25Renal cortical cysts (HP:0000803)3.45251264
26Choroideremia (HP:0001139)3.26611553
27Progressive visual loss (HP:0000529)3.20602929
28Methylmalonic acidemia (HP:0002912)3.02934019
29Abnormality of the renal cortex (HP:0011035)3.00496330
30Stomatitis (HP:0010280)2.95245768
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.85602335
32Abnormality of alanine metabolism (HP:0010916)2.85379010
33Hyperalaninemia (HP:0003348)2.85379010
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.85379010
35Gaze-evoked nystagmus (HP:0000640)2.68987496
36Congenital sensorineural hearing impairment (HP:0008527)2.56880571
37Atonic seizures (HP:0010819)2.54812726
38Methylmalonic aciduria (HP:0012120)2.50107944
39Type II lissencephaly (HP:0007260)2.42893859
40Hyperventilation (HP:0002883)2.39243256
413-Methylglutaconic aciduria (HP:0003535)2.39056759
42Progressive macrocephaly (HP:0004481)2.36573227
43Wide nasal bridge (HP:0000431)2.34640425
44Acute encephalopathy (HP:0006846)2.33919901
45Dialeptic seizures (HP:0011146)2.32352817
46Pancreatic fibrosis (HP:0100732)2.29950377
47True hermaphroditism (HP:0010459)2.29788907
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28721508
49Abnormal protein N-linked glycosylation (HP:0012347)2.28721508
50Abnormal protein glycosylation (HP:0012346)2.28721508
51Abnormal glycosylation (HP:0012345)2.28721508
52Fair hair (HP:0002286)2.25788801
53Acute necrotizing encephalopathy (HP:0006965)2.24788811
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.22639487
55Increased CSF lactate (HP:0002490)2.21846604
56Focal seizures (HP:0007359)2.21628501
57Absence seizures (HP:0002121)2.17749036
58Hemiparesis (HP:0001269)2.16999919
59Progressive inability to walk (HP:0002505)2.15310570
60Polar cataract (HP:0010696)2.14955499
61Abnormality of vitamin B metabolism (HP:0004340)2.13400004
62Gait imbalance (HP:0002141)2.12993251
63Congenital primary aphakia (HP:0007707)2.09355337
64Hepatic necrosis (HP:0002605)2.05885745
65Mitochondrial inheritance (HP:0001427)2.04765890
66Abnormality of the labia minora (HP:0012880)2.03056958
67Retinal atrophy (HP:0001105)2.02551193
68Congenital, generalized hypertrichosis (HP:0004540)2.01355818
69Absent rod-and cone-mediated responses on ERG (HP:0007688)11.7417538
70Congenital stationary night blindness (HP:0007642)10.6227890
71Abnormal rod and cone electroretinograms (HP:0008323)10.5314706
72Hepatocellular necrosis (HP:0001404)1.97267938
73Optic disc pallor (HP:0000543)1.96099457
74Hypoalbuminemia (HP:0003073)1.93977098
75Abnormal albumin level (HP:0012116)1.93977098
76Abnormality of methionine metabolism (HP:0010901)1.93288958
77Abnormal respiratory motile cilium morphology (HP:0005938)1.90933027
78Abnormal respiratory epithelium morphology (HP:0012253)1.90933027
79Stomach cancer (HP:0012126)1.89505106
80Abnormality of the vitamin B12 metabolism (HP:0004341)1.88436203
81Nephrogenic diabetes insipidus (HP:0009806)1.88337099
82Broad-based gait (HP:0002136)1.88205269
83Sclerocornea (HP:0000647)1.86143655
84Large for gestational age (HP:0001520)1.85979237
85Medial flaring of the eyebrow (HP:0010747)1.85189122
86Pancreatic cysts (HP:0001737)1.85149887
87Inability to walk (HP:0002540)1.84261060
88Type I transferrin isoform profile (HP:0003642)1.83692470
89Abnormal pancreas size (HP:0012094)1.83632516
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.83527711
91Bile duct proliferation (HP:0001408)1.83235342
92Abnormal biliary tract physiology (HP:0012439)1.83235342
93Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83193312
94Cerebellar dysplasia (HP:0007033)1.82762422
95Cystic liver disease (HP:0006706)1.81589622
96Abnormality of the pons (HP:0007361)1.80822901
97Intrahepatic cholestasis (HP:0001406)1.80114825
98Abnormal mitochondria in muscle tissue (HP:0008316)1.79031023
99Abnormality of homocysteine metabolism (HP:0010919)1.78180420
100Homocystinuria (HP:0002156)1.78180420
101Dynein arm defect of respiratory motile cilia (HP:0012255)1.76883729
102Absent/shortened dynein arms (HP:0200106)1.76883729
103Generalized hypopigmentation of hair (HP:0011358)1.76829792
104Hypothermia (HP:0002045)1.74098961
105Severe Myopia (HP:0011003)1.67127183
106Poor coordination (HP:0002370)1.64431402
107Vaginal atresia (HP:0000148)1.52812567
108Optic atrophy (HP:0000648)1.52756047
109Genital tract atresia (HP:0001827)1.51080208
110Horizontal nystagmus (HP:0000666)1.48173781
111Aplasia/Hypoplasia of the lens (HP:0008063)1.39602181
112Interstitial pulmonary disease (HP:0006530)1.35047054
113Septo-optic dysplasia (HP:0100842)1.30224107
114Epileptic encephalopathy (HP:0200134)1.30174190
115Abnormality of the fovea (HP:0000493)1.29662924
116Hypoplasia of the fovea (HP:0007750)1.25398566
117Aplasia/Hypoplasia of the fovea (HP:0008060)1.25398566
118Chorioretinal coloboma (HP:0000567)1.22657492
119Anencephaly (HP:0002323)1.20186915
120Anophthalmia (HP:0000528)1.16372645
121Furrowed tongue (HP:0000221)1.15525850
122Dysdiadochokinesis (HP:0002075)1.14135967
123Abnormality of midbrain morphology (HP:0002418)1.13098975
124Molar tooth sign on MRI (HP:0002419)1.13098975
125Congenital hepatic fibrosis (HP:0002612)1.07605785
126Recurrent sinusitis (HP:0011108)1.06758141
127Hypermetropia (HP:0000540)1.06241071
128Aplasia/Hypoplasia of the macula (HP:0008059)1.06154048
129Febrile seizures (HP:0002373)1.06028586
130Abnormality of abdominal situs (HP:0011620)1.03526565
131Abdominal situs inversus (HP:0003363)1.03526565
132Astigmatism (HP:0000483)1.02520738
133Postaxial foot polydactyly (HP:0001830)0.99493380
134Aplasia/Hypoplasia affecting the retina (HP:0008061)0.98493485
135Visual hallucinations (HP:0002367)0.97386588
136Genetic anticipation (HP:0003743)0.95097703
137Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.94545618
138Progressive cerebellar ataxia (HP:0002073)0.94091861
139Oligodactyly (hands) (HP:0001180)0.91410160
140Specific learning disability (HP:0001328)0.90556053
141Retinal detachment (HP:0000541)0.89616419
142Abnormality of the fingertips (HP:0001211)0.89118283
143Abnormality of the lower motor neuron (HP:0002366)0.88839083
144Nephronophthisis (HP:0000090)0.88260191
145Preaxial hand polydactyly (HP:0001177)0.86533274
146Postaxial hand polydactyly (HP:0001162)0.86284803
147Lip pit (HP:0100267)0.84705837
148Abnormality of the parathyroid morphology (HP:0011766)0.82691196
149Male pseudohermaphroditism (HP:0000037)0.82266099
150Asthma (HP:0002099)0.81770326
151Left ventricular hypertrophy (HP:0001712)0.80504797
152Broad foot (HP:0001769)0.79364325
153Supranuclear gaze palsy (HP:0000605)0.75474776
154Decreased testicular size (HP:0008734)0.74877584
155Abnormality of the renal medulla (HP:0100957)0.71585796
156Insomnia (HP:0100785)0.71529750
157Absent septum pellucidum (HP:0001331)0.69443093
158Abnormality of dental color (HP:0011073)0.68773850
159Aqueductal stenosis (HP:0002410)0.68691331
160Holoprosencephaly (HP:0001360)0.68666314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK17.21111519
2FRK6.40134247
3IRAK23.89686485
4MAP3K103.32727832
5ADRBK23.14419504
6MAP4K23.03105788
7WNK32.78891617
8PBK2.69913317
9PINK12.54805309
10PDK22.25973648
11TRIM282.21228239
12LATS12.06535438
13SIK22.04341831
14CAMK1G1.96269252
15CDK121.96005577
16OXSR11.90976872
17BRD41.89439663
18MAP3K41.86225157
19WNK41.85054243
20PNCK1.84373710
21SGK4941.82075938
22SGK2231.82075938
23ZAK1.80629499
24PAK61.78466236
25EIF2AK31.74171644
26ERBB21.68304969
27BMPR1B1.67372566
28LMTK21.64746440
29FER1.64603080
30CDK31.57353869
31TAOK31.53633105
32ICK1.52403136
33STK391.51861013
34CAMKK21.45714531
35ACVR1B1.45121426
36MAP3K61.38200155
37CAMK1D1.35095160
38TXK1.34560005
39PRPF4B1.30214630
40STK381.30179142
41MATK1.29603701
42DAPK21.29587597
43PRKD31.28791526
44MAP3K91.28128922
45HIPK21.26785957
46MAP2K71.25498331
47NLK1.21500279
48TNIK1.21466093
49INSRR1.20069476
50CDK91.15618437
51MARK11.14303260
52ADRBK11.13269955
53NTRK21.12660042
54DYRK1A1.11201262
55DYRK21.10824861
56MAPK121.08219296
57MAPK71.05018477
58CSNK1D1.00877794
59PRKCE0.99660605
60PRKCH0.99036256
61KSR10.96265533
62WNK10.94817110
63VRK20.92466128
64SGK20.91350145
65IKBKB0.89964782
66MKNK20.89882388
67PIK3CG0.87849197
68PRKCQ0.87182049
69PLK20.86093638
70PRKAA10.85924032
71PRKCG0.84043066
72VRK10.83222582
73PRKD20.83163568
74IRAK10.82954261
75BRSK20.80823202
76NUAK10.78708446
77NEK20.78588843
78LIMK10.77966239
79PIK3CA0.76409342
80AKT30.75937166
81MST40.74809912
82MAP2K40.74721002
83SIK30.73924974
84SIK10.72822736
85PRKAA20.72206308
86DYRK30.70809976
87STK160.70563320
88CDK190.69778901
89SGK10.69088418
90CSNK1G10.68648028
91MAPK130.68317623
92GSK3B0.68127047
93TLK10.68079889
94NTRK30.67148842
95MAPK100.65659530
96MARK20.64194736
97GRK50.64189993
98MAPK140.64112876
99CAMK2A0.63895746
100SGK30.63539300
101PRKCB0.63436078
102CASK0.62723855
103PHKG20.62648091
104PHKG10.62648091
105KSR20.61897289
106PRKCZ0.61120684
107RPS6KA30.60882348
108TIE10.60242540
109BCR0.59666670
110CDK10.58308966
111CDK50.58263914
112MAP3K130.58062399
113DYRK1B0.57047704
114MAPK90.56812741
115CSNK1G30.55959397
116TEC0.54992834
117TNK20.54616802
118PLK30.53453220
119CDK80.53268857
120CAMK10.53083367
121TTK0.52849651
122PRKG20.51497181
123MUSK0.50822514
124CAMK2D0.50170671
125EPHA30.49369778
126TAOK10.49280172
127CHEK20.48975120
128CSNK1A1L0.48834062
129BMPR20.48435123
130STK110.48260400
131MINK10.47055480
132MAP3K70.46863681
133ATM0.45171660
134PAK30.43545657
135NEK60.43508038
136CHEK10.43441644
137RET0.43388131
138CSNK1E0.43185905
139RPS6KA40.42642507
140GRK60.42480967
141PRKACA0.42026649
142KIT0.41076931
143FES0.40624167
144NEK10.40208647
145BUB10.39933703
146CDC42BPA0.39654979
147MAP3K120.39030725
148PKN10.38568165
149PRKDC0.38203788
150EPHA40.37466558
151PRKCA0.37426561
152BRAF0.37266667
153ITK0.36734573
154PRKACG0.34820147
155MAP3K50.34711599
156CSNK1G20.33785438
157PRKACB0.33783213
158MAP2K20.33723686
159MAP4K10.33462900
160CHUK0.33396725
161PRKCI0.33149426
162PRKG10.32882573
163PLK40.32369186
164CSNK1A10.32175003
165FGFR20.28815236
166STK38L0.28460467
167NME10.28123797

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.31301996
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.89697508
3Protein export_Homo sapiens_hsa030602.73585531
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.47073271
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.35001757
6Butanoate metabolism_Homo sapiens_hsa006502.11199472
7Synaptic vesicle cycle_Homo sapiens_hsa047212.09430423
8Oxidative phosphorylation_Homo sapiens_hsa001902.08116887
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.06017057
10Phototransduction_Homo sapiens_hsa0474414.4110034
11Caffeine metabolism_Homo sapiens_hsa002321.84743754
12Nitrogen metabolism_Homo sapiens_hsa009101.83470396
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79963739
14Olfactory transduction_Homo sapiens_hsa047401.77728802
15Sulfur metabolism_Homo sapiens_hsa009201.72677520
16GABAergic synapse_Homo sapiens_hsa047271.71664327
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.70694072
18Basal transcription factors_Homo sapiens_hsa030221.58536592
19RNA polymerase_Homo sapiens_hsa030201.57777430
20Tryptophan metabolism_Homo sapiens_hsa003801.53969331
21Selenocompound metabolism_Homo sapiens_hsa004501.46073756
22Circadian rhythm_Homo sapiens_hsa047101.45402818
23Chemical carcinogenesis_Homo sapiens_hsa052041.43264028
24Proteasome_Homo sapiens_hsa030501.43188057
25Parkinsons disease_Homo sapiens_hsa050121.42348791
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39877182
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39864625
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36395729
29One carbon pool by folate_Homo sapiens_hsa006701.34564899
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34339922
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34038196
32Glutamatergic synapse_Homo sapiens_hsa047241.32415564
33Homologous recombination_Homo sapiens_hsa034401.30586558
34Circadian entrainment_Homo sapiens_hsa047131.27520068
35Peroxisome_Homo sapiens_hsa041461.25167953
36Morphine addiction_Homo sapiens_hsa050321.23862466
37Cholinergic synapse_Homo sapiens_hsa047251.22887684
38Propanoate metabolism_Homo sapiens_hsa006401.19304892
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.17058309
40Fat digestion and absorption_Homo sapiens_hsa049751.16557972
41Nicotine addiction_Homo sapiens_hsa050331.11066854
42Serotonergic synapse_Homo sapiens_hsa047261.07712635
43Dopaminergic synapse_Homo sapiens_hsa047281.06434372
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.04486031
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00879332
46Regulation of autophagy_Homo sapiens_hsa041400.95607334
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.95075037
48Asthma_Homo sapiens_hsa053100.93765095
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92864449
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92256489
51Histidine metabolism_Homo sapiens_hsa003400.91482720
52Huntingtons disease_Homo sapiens_hsa050160.90233748
53Steroid biosynthesis_Homo sapiens_hsa001000.88728032
54Collecting duct acid secretion_Homo sapiens_hsa049660.87049126
55Insulin secretion_Homo sapiens_hsa049110.86923950
56Alzheimers disease_Homo sapiens_hsa050100.84976441
57Fanconi anemia pathway_Homo sapiens_hsa034600.84523578
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84269182
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82674535
60Primary immunodeficiency_Homo sapiens_hsa053400.80620709
61Arachidonic acid metabolism_Homo sapiens_hsa005900.78872836
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77957521
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77257512
64Retinol metabolism_Homo sapiens_hsa008300.75951684
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73428839
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73030802
67Oxytocin signaling pathway_Homo sapiens_hsa049210.71922866
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70472745
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70065752
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69807598
71Metabolic pathways_Homo sapiens_hsa011000.67946055
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66367924
73Vitamin digestion and absorption_Homo sapiens_hsa049770.66332064
74Salivary secretion_Homo sapiens_hsa049700.66289055
75Glutathione metabolism_Homo sapiens_hsa004800.65115453
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64592488
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64469434
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63496000
79N-Glycan biosynthesis_Homo sapiens_hsa005100.63493866
80cAMP signaling pathway_Homo sapiens_hsa040240.62948816
81ABC transporters_Homo sapiens_hsa020100.62878052
82Type I diabetes mellitus_Homo sapiens_hsa049400.62186859
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62181394
84Inositol phosphate metabolism_Homo sapiens_hsa005620.58286010
85mTOR signaling pathway_Homo sapiens_hsa041500.55496740
86beta-Alanine metabolism_Homo sapiens_hsa004100.54512951
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54276591
88Non-homologous end-joining_Homo sapiens_hsa034500.53373249
89Axon guidance_Homo sapiens_hsa043600.53162547
90Allograft rejection_Homo sapiens_hsa053300.52694174
91Long-term potentiation_Homo sapiens_hsa047200.52061918
92Fatty acid metabolism_Homo sapiens_hsa012120.51921928
93Ovarian steroidogenesis_Homo sapiens_hsa049130.51906573
94Renin secretion_Homo sapiens_hsa049240.51246329
95Rheumatoid arthritis_Homo sapiens_hsa053230.51158865
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50176373
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49517735
98Lysine degradation_Homo sapiens_hsa003100.48945669
99Graft-versus-host disease_Homo sapiens_hsa053320.48267105
100Gastric acid secretion_Homo sapiens_hsa049710.48086978
101Cardiac muscle contraction_Homo sapiens_hsa042600.47556344
102Cocaine addiction_Homo sapiens_hsa050300.47425875
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.47145583
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46898821
105Renal cell carcinoma_Homo sapiens_hsa052110.46606125
106GnRH signaling pathway_Homo sapiens_hsa049120.45772878
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45562121
108Dilated cardiomyopathy_Homo sapiens_hsa054140.45168873
109Ether lipid metabolism_Homo sapiens_hsa005650.44464813
110Amphetamine addiction_Homo sapiens_hsa050310.44376356
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.44282536
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42069128
113Type II diabetes mellitus_Homo sapiens_hsa049300.41382028
114Ras signaling pathway_Homo sapiens_hsa040140.41051104
115Choline metabolism in cancer_Homo sapiens_hsa052310.39164250
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38648925
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38290962
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37414521
119Dorso-ventral axis formation_Homo sapiens_hsa043200.37023526
120Mineral absorption_Homo sapiens_hsa049780.36725920
121Calcium signaling pathway_Homo sapiens_hsa040200.36160711
122Linoleic acid metabolism_Homo sapiens_hsa005910.35883610
123mRNA surveillance pathway_Homo sapiens_hsa030150.35486460
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35292450
125Fatty acid degradation_Homo sapiens_hsa000710.34899200
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34487413
127Pyrimidine metabolism_Homo sapiens_hsa002400.33980156
128Glycerolipid metabolism_Homo sapiens_hsa005610.33306082
129Wnt signaling pathway_Homo sapiens_hsa043100.33108176
130Notch signaling pathway_Homo sapiens_hsa043300.32963678
131MAPK signaling pathway_Homo sapiens_hsa040100.32509333
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.32187462
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.31910535
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.31812044
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31257608
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30972402
137Long-term depression_Homo sapiens_hsa047300.30413261
138ErbB signaling pathway_Homo sapiens_hsa040120.30217051
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30104435
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29590941
141Glucagon signaling pathway_Homo sapiens_hsa049220.29445080
142Hippo signaling pathway_Homo sapiens_hsa043900.29438251
143Tight junction_Homo sapiens_hsa045300.28426395
144Taste transduction_Homo sapiens_hsa047420.28365718
145Fatty acid elongation_Homo sapiens_hsa000620.28356278
146HIF-1 signaling pathway_Homo sapiens_hsa040660.27744091
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27029908
148Alcoholism_Homo sapiens_hsa050340.26476564
149RNA degradation_Homo sapiens_hsa030180.26103333
150Endometrial cancer_Homo sapiens_hsa052130.26041357
151Purine metabolism_Homo sapiens_hsa002300.25679331
152Glioma_Homo sapiens_hsa052140.25587079
153Bile secretion_Homo sapiens_hsa049760.24526398
154Chemokine signaling pathway_Homo sapiens_hsa040620.24044312
155Pancreatic secretion_Homo sapiens_hsa049720.23482491
156Oocyte meiosis_Homo sapiens_hsa041140.23246386
157Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22468294
158Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22364913
159VEGF signaling pathway_Homo sapiens_hsa043700.21888873
160Thyroid hormone synthesis_Homo sapiens_hsa049180.21547500
161AMPK signaling pathway_Homo sapiens_hsa041520.20436675
162Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18788330
163Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18222329
164Melanogenesis_Homo sapiens_hsa049160.17786897
165Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17574696
166Non-small cell lung cancer_Homo sapiens_hsa052230.15823325
167Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15144572
168Fatty acid biosynthesis_Homo sapiens_hsa000610.15122772

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