SAMD4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)4.30914849
2regulation of glucose import in response to insulin stimulus (GO:2001273)4.08130450
3regulation of hippo signaling (GO:0035330)4.07957973
4polarized epithelial cell differentiation (GO:0030859)3.98708182
5pre-miRNA processing (GO:0031054)3.88647834
6activation of Rac GTPase activity (GO:0032863)3.80294972
7hippo signaling (GO:0035329)3.75192036
8synaptic vesicle docking involved in exocytosis (GO:0016081)3.57490643
9cytoskeletal anchoring at plasma membrane (GO:0007016)3.52882878
10regulation of gene silencing by RNA (GO:0060966)3.50064869
11regulation of posttranscriptional gene silencing (GO:0060147)3.50064869
12regulation of gene silencing by miRNA (GO:0060964)3.50064869
13regulation of NFAT protein import into nucleus (GO:0051532)3.41982548
14desmosome organization (GO:0002934)3.38930679
15regulation of fatty acid beta-oxidation (GO:0031998)3.38789653
16positive regulation of fatty acid beta-oxidation (GO:0032000)3.35496832
17regulation of SMAD protein import into nucleus (GO:0060390)3.31995488
18Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.31829910
19establishment of apical/basal cell polarity (GO:0035089)3.30342226
20positive regulation of SMAD protein import into nucleus (GO:0060391)3.29991264
21paraxial mesoderm development (GO:0048339)3.24144066
22apoptotic process involved in morphogenesis (GO:0060561)3.23692409
23NLS-bearing protein import into nucleus (GO:0006607)3.17078640
24regulation of mammary gland epithelial cell proliferation (GO:0033599)3.12904415
25atrioventricular valve morphogenesis (GO:0003181)3.12271783
26adherens junction assembly (GO:0034333)3.11553252
27convergent extension (GO:0060026)3.11101947
28myelin maintenance (GO:0043217)3.11068631
29anterior/posterior axis specification, embryo (GO:0008595)3.10777739
30regulation of establishment of planar polarity (GO:0090175)3.10456222
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.05233177
32intracellular estrogen receptor signaling pathway (GO:0030520)3.05072325
33regulation of early endosome to late endosome transport (GO:2000641)3.03499509
34cochlea morphogenesis (GO:0090103)3.02713860
35protein localization to endosome (GO:0036010)2.99493625
36endothelial cell chemotaxis (GO:0035767)2.99017974
37insulin-like growth factor receptor signaling pathway (GO:0048009)2.98685517
38planar cell polarity pathway involved in neural tube closure (GO:0090179)2.94695994
39cytoplasmic mRNA processing body assembly (GO:0033962)2.93090177
40neural tube development (GO:0021915)2.92151920
41synaptonemal complex assembly (GO:0007130)2.91351462
42trophectodermal cell differentiation (GO:0001829)2.88966301
43negative regulation of cell size (GO:0045792)2.85139221
44skin morphogenesis (GO:0043589)2.84450987
45regulation of RNA export from nucleus (GO:0046831)2.83680684
46stress fiber assembly (GO:0043149)2.83093776
47protein retention in ER lumen (GO:0006621)2.81916190
48mammary gland epithelial cell differentiation (GO:0060644)2.79949382
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.77278761
50labyrinthine layer blood vessel development (GO:0060716)2.77193931
51protein heterotrimerization (GO:0070208)2.76206300
52negative regulation of fatty acid transport (GO:2000192)2.75654076
53cell-substrate junction assembly (GO:0007044)2.74717743
54establishment of monopolar cell polarity (GO:0061162)2.74541702
55establishment or maintenance of monopolar cell polarity (GO:0061339)2.74541702
56regulation of translational fidelity (GO:0006450)2.70741657
57semaphorin-plexin signaling pathway (GO:0071526)2.68714796
58regulation of chromatin binding (GO:0035561)2.68059576
59branching involved in salivary gland morphogenesis (GO:0060445)2.67450892
60epithelial cell-cell adhesion (GO:0090136)2.66994839
61positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.66080993
62regulation of apoptotic process involved in morphogenesis (GO:1902337)2.64447561
63lung epithelium development (GO:0060428)2.64217614
64endodermal cell differentiation (GO:0035987)2.62524757
65positive regulation of blood vessel endothelial cell migration (GO:0043536)2.61786182
66cell-substrate adherens junction assembly (GO:0007045)2.61597031
67focal adhesion assembly (GO:0048041)2.61597031
68synaptonemal complex organization (GO:0070193)2.61564315
69chromatin silencing (GO:0006342)2.60852309
70vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.60559947
71wound healing, spreading of epidermal cells (GO:0035313)2.60433127
72positive regulation of gene expression, epigenetic (GO:0045815)2.58369857
73positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.58011965
74basement membrane organization (GO:0071711)2.57993594
75anatomical structure regression (GO:0060033)2.57436200
76apoptotic process involved in development (GO:1902742)2.57101272
77negative regulation of erythrocyte differentiation (GO:0045647)2.55674855
78gene silencing (GO:0016458)2.54345821
79positive regulation of cellular response to insulin stimulus (GO:1900078)2.53989109
80gene silencing by RNA (GO:0031047)2.53620855
81apoptotic cell clearance (GO:0043277)2.53526550
82endothelial cell morphogenesis (GO:0001886)2.52847114
83glucocorticoid receptor signaling pathway (GO:0042921)2.52087304
84placenta blood vessel development (GO:0060674)2.50905375
85non-canonical Wnt signaling pathway (GO:0035567)2.49549829
86lens fiber cell development (GO:0070307)2.49307793
87response to laminar fluid shear stress (GO:0034616)2.48953983
88establishment or maintenance of apical/basal cell polarity (GO:0035088)2.48863318
89establishment or maintenance of bipolar cell polarity (GO:0061245)2.48863318
90myelination in peripheral nervous system (GO:0022011)2.46085867
91peripheral nervous system axon ensheathment (GO:0032292)2.46085867
92positive regulation of histone deacetylation (GO:0031065)2.45821134
93embryonic camera-type eye development (GO:0031076)2.45470696
94craniofacial suture morphogenesis (GO:0097094)2.44609503
95protein targeting to plasma membrane (GO:0072661)2.44250590
96activation of MAPKKK activity (GO:0000185)2.44150350
97establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.43653397
98plasma membrane repair (GO:0001778)2.42272275
99negative regulation of myotube differentiation (GO:0010832)2.42005773
100positive regulation of CREB transcription factor activity (GO:0032793)2.41636146
101neural tube closure (GO:0001843)2.41464522
102bone trabecula formation (GO:0060346)2.39992584
103negative regulation of catenin import into nucleus (GO:0035414)2.39988754
104vascular endothelial growth factor signaling pathway (GO:0038084)2.39391074
105collecting duct development (GO:0072044)2.39302021
106cell-cell junction maintenance (GO:0045217)2.38938574
107activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38149650
108RNA stabilization (GO:0043489)2.37814274
109mRNA stabilization (GO:0048255)2.37814274
110positive regulation of synapse maturation (GO:0090129)2.37569600
111cortical actin cytoskeleton organization (GO:0030866)2.37344598
112tube closure (GO:0060606)2.37300007
113cell junction maintenance (GO:0034331)2.36665306
114cell adhesion mediated by integrin (GO:0033627)2.35629918
115embryonic eye morphogenesis (GO:0048048)2.35274523
116eye morphogenesis (GO:0048592)2.34267115
117Golgi transport vesicle coating (GO:0048200)2.34012283
118COPI coating of Golgi vesicle (GO:0048205)2.34012283
119mannose metabolic process (GO:0006013)2.33382278
120dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.33327384
121negative regulation of striated muscle cell differentiation (GO:0051154)2.32692573
122chondrocyte proliferation (GO:0035988)2.32189213
123regulation of nucleobase-containing compound transport (GO:0032239)2.31483037
124negative regulation of smooth muscle cell migration (GO:0014912)2.30698118
125body morphogenesis (GO:0010171)2.30400917
126negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.30133356
127regulation of stem cell maintenance (GO:2000036)2.29635778
128regulation of ARF GTPase activity (GO:0032312)2.28296863
129positive regulation of nuclease activity (GO:0032075)2.28255900
130endocardial cushion development (GO:0003197)2.28150957
131G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.27873443
132negative regulation of glial cell proliferation (GO:0060253)2.27867395
133positive regulation of protein dephosphorylation (GO:0035307)2.27662913
134positive regulation of epithelial to mesenchymal transition (GO:0010718)2.27427746
135histone H4-K12 acetylation (GO:0043983)2.27372288
136embryonic foregut morphogenesis (GO:0048617)2.27179733
137retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.26512789
138positive regulation of macroautophagy (GO:0016239)2.26477071
139epithelial cell fate commitment (GO:0072148)2.25849760
140modulation by virus of host morphology or physiology (GO:0019048)2.25494046
141chromatin assembly (GO:0031497)2.25359568
142actin filament bundle assembly (GO:0051017)2.25099908
143actin filament bundle organization (GO:0061572)2.25099908
144outflow tract septum morphogenesis (GO:0003148)2.24090879
145regulation of p38MAPK cascade (GO:1900744)2.24069502
146embryonic body morphogenesis (GO:0010172)2.24006988
147renal system development (GO:0072001)2.23973437
148lateral sprouting from an epithelium (GO:0060601)2.23749510
149nuclear pore complex assembly (GO:0051292)2.23745519
150camera-type eye morphogenesis (GO:0048593)2.23009011
151cell volume homeostasis (GO:0006884)2.22976211
152regulation of catenin import into nucleus (GO:0035412)2.22592923
153adherens junction organization (GO:0034332)2.21752853
154wound healing, spreading of cells (GO:0044319)2.21695664
155hemidesmosome assembly (GO:0031581)2.21601185
156regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.21466535
157lung-associated mesenchyme development (GO:0060484)2.21081859
158osteoblast development (GO:0002076)2.21022129
159platelet-derived growth factor receptor signaling pathway (GO:0048008)2.20412237
160sodium ion export (GO:0071436)2.20158622
161peptidyl-lysine dimethylation (GO:0018027)2.19528744
162bone morphogenesis (GO:0060349)2.19000575
163regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.18259756
164regulation of ARF protein signal transduction (GO:0032012)2.18170019

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human3.69211694
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.68962391
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.25531866
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.04615889
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.64933711
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.49677688
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.39108073
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.37416939
9KDM2B_26808549_Chip-Seq_DND41_Human2.37199213
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.36203307
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29270454
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.25108776
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23494048
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23494048
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23494048
16MYC_22102868_ChIP-Seq_BL_Human2.21357577
17* ELK3_25401928_ChIP-Seq_HUVEC_Human2.18673437
18ZFP281_27345836_Chip-Seq_ESCs_Mouse2.07200926
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.04284635
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03069484
21EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.02705267
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01995530
23ZNF263_19887448_ChIP-Seq_K562_Human1.98807100
24KDM2B_26808549_Chip-Seq_K562_Human1.96984977
25RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.96589786
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93972904
27P300_27058665_Chip-Seq_ZR-75-30cells_Human1.93714740
28RACK7_27058665_Chip-Seq_MCF-7_Human1.93625515
29* TCF7_22412390_ChIP-Seq_EML_Mouse1.93295275
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93071020
31* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82795218
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79644199
33LXR_22292898_ChIP-Seq_THP-1_Human1.77615371
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.77588815
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77092512
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72436233
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70983423
38P68_20966046_ChIP-Seq_HELA_Human1.69619823
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.68704615
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.68523712
41* ATF3_27146783_Chip-Seq_COLON_Human1.64198328
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62768167
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.60172758
44SMC4_20622854_ChIP-Seq_HELA_Human1.58676424
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58390946
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.58186850
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55592291
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55036524
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.54631328
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54382167
51TP53_22127205_ChIP-Seq_IMR90_Human1.54232400
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53709519
53VDR_21846776_ChIP-Seq_THP-1_Human1.51595350
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.50287824
55CREB1_26743006_Chip-Seq_LNCaP_Human1.48232461
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46988700
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.44933619
58NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.44639550
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44160852
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.42945663
61* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38362847
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38204515
63* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37507501
64* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35950278
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34882195
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33338528
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33251570
68TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31451677
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30809548
70CTCF_27219007_Chip-Seq_Bcells_Human1.28962704
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27765108
72CLOCK_20551151_ChIP-Seq_293T_Human1.27550612
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.26869554
74FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.25727986
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25072355
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.23016651
77NCOR1_26117541_ChIP-Seq_K562_Human1.22598212
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22108567
79PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.20616778
80DROSHA_22980978_ChIP-Seq_HELA_Human1.20197320
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.19306212
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18418673
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17973996
84POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17543508
85TP53_23651856_ChIP-Seq_MEFs_Mouse1.16438713
86SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15853441
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.15508382
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.14915428
89TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.14310386
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14208444
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13888035
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.12831971
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12460083
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11141271
95* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11022091
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09694261
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09444995
98RARB_27405468_Chip-Seq_BRAIN_Mouse1.09287495
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08204951
100TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07040554
101SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06106674
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05973553
103TBX20_22080862_ChIP-Seq_HEART_Mouse1.05633514
104TBX20_22328084_ChIP-Seq_HEART_Mouse1.05633514
105MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04948678
106TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04933495
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04756122
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01771163
109EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01647695
110CHD1_26751641_Chip-Seq_LNCaP_Human1.00182105
111ELF1_20517297_ChIP-Seq_JURKAT_Human0.99744082
112FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99572298
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.99302246
114JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99127997
115* NANOG_21062744_ChIP-ChIP_HESCs_Human0.99051916
116CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98863149
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97750633
118* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97446799
119STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97088082
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95748025
121EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95317303
122RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95317303
123TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95139939
124* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94944394
125* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94913058
126SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94683932
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94510355
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.94215458
129PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93384136
130OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93119611
131GATA1_26923725_Chip-Seq_HPCs_Mouse0.92120107
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91550755
133TP63_22573176_ChIP-Seq_HFKS_Human0.91252939
134GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90329661
135* KLF5_25053715_ChIP-Seq_YYC3_Human0.90089866
136UTX_26944678_Chip-Seq_JUKART_Human0.90054952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.93920514
2MP0005623_abnormal_meninges_morphology3.09804408
3MP0010352_gastrointestinal_tract_polyps3.08458246
4MP0008438_abnormal_cutaneous_collagen3.05328466
5MP0002249_abnormal_larynx_morphology2.96924785
6MP0005076_abnormal_cell_differentiation2.75929457
7MP0002653_abnormal_ependyma_morphology2.75711943
8MP0000566_synostosis2.61299450
9MP0005409_darkened_coat_color2.31278788
10MP0003566_abnormal_cell_adhesion2.27643598
11MP0010030_abnormal_orbit_morphology2.27568091
12MP0000678_abnormal_parathyroid_gland2.19991173
13MP0004272_abnormal_basement_membrane2.16294541
14MP0001849_ear_inflammation2.01456840
15MP0000733_abnormal_muscle_development2.01418748
16MP0000537_abnormal_urethra_morphology2.00291005
17MP0003283_abnormal_digestive_organ1.83149522
18MP0009278_abnormal_bone_marrow1.81273630
19MP0003091_abnormal_cell_migration1.71479600
20MP0009053_abnormal_anal_canal1.70035093
21MP0005275_abnormal_skin_tensile1.69213878
22MP0005410_abnormal_fertilization1.67281530
23MP0004858_abnormal_nervous_system1.67248938
24MP0000428_abnormal_craniofacial_morphol1.65714504
25MP0005503_abnormal_tendon_morphology1.63756392
26MP0005666_abnormal_adipose_tissue1.63696596
27MP0003115_abnormal_respiratory_system1.63640406
28MP0004197_abnormal_fetal_growth/weight/1.62990007
29MP0002796_impaired_skin_barrier1.57798225
30MP0000579_abnormal_nail_morphology1.57584043
31MP0005670_abnormal_white_adipose1.56052504
32MP0005023_abnormal_wound_healing1.55084141
33MP0002084_abnormal_developmental_patter1.52928232
34MP0003385_abnormal_body_wall1.51485046
35MP0005257_abnormal_intraocular_pressure1.50986223
36MP0001958_emphysema1.50866754
37MP0000534_abnormal_ureter_morphology1.50076934
38MP0003119_abnormal_digestive_system1.46856867
39MP0002877_abnormal_melanocyte_morpholog1.45777896
40MP0001730_embryonic_growth_arrest1.44894870
41MP0003303_peritoneal_inflammation1.44731646
42MP0002085_abnormal_embryonic_tissue1.43917409
43MP0001348_abnormal_lacrimal_gland1.41564325
44MP0004859_abnormal_synaptic_plasticity1.40480097
45MP0003279_aneurysm1.39476753
46MP0002060_abnormal_skin_morphology1.38776548
47MP0003300_gastrointestinal_ulcer1.34615639
48MP0005508_abnormal_skeleton_morphology1.33983499
49MP0002254_reproductive_system_inflammat1.32039045
50MP0003984_embryonic_growth_retardation1.31605407
51MP0002088_abnormal_embryonic_growth/wei1.30748918
52MP0005380_embryogenesis_phenotype1.29609767
53MP0001672_abnormal_embryogenesis/_devel1.29609767
54MP0004233_abnormal_muscle_weight1.29506647
55MP0002925_abnormal_cardiovascular_devel1.26272182
56MP0002086_abnormal_extraembryonic_tissu1.26260371
57MP0004185_abnormal_adipocyte_glucose1.26153291
58MP0001299_abnormal_eye_distance/1.23868565
59MP0001697_abnormal_embryo_size1.23701672
60MP0005501_abnormal_skin_physiology1.23426085
61MP0003045_fibrosis1.22156119
62MP0005451_abnormal_body_composition1.21616723
63MP0003942_abnormal_urinary_system1.21442309
64MP0003755_abnormal_palate_morphology1.19670952
65MP0000432_abnormal_head_morphology1.16421664
66MP0000751_myopathy1.16312391
67MP0003935_abnormal_craniofacial_develop1.15804452
68MP0002282_abnormal_trachea_morphology1.15026932
69MP0000762_abnormal_tongue_morphology1.14102013
70MP0003453_abnormal_keratinocyte_physiol1.11687347
71MP0000350_abnormal_cell_proliferation1.11375948
72MP0005058_abnormal_lysosome_morphology1.11112705
73MP0003172_abnormal_lysosome_physiology1.09356999
74MP0003941_abnormal_skin_development1.08480689
75MP0002089_abnormal_postnatal_growth/wei1.08225801
76MP0003937_abnormal_limbs/digits/tail_de1.07679522
77MP0001915_intracranial_hemorrhage1.07212760
78MP0001502_abnormal_circadian_rhythm1.05013530
79MP0006138_congestive_heart_failure1.03770217
80MP0002697_abnormal_eye_size1.03756144
81MP0001293_anophthalmia1.01500219
82MP0002098_abnormal_vibrissa_morphology1.01219114
83MP0002092_abnormal_eye_morphology1.00668182
84MP0002116_abnormal_craniofacial_bone0.99809180
85MP0003123_paternal_imprinting0.98894895
86MP0002932_abnormal_joint_morphology0.98555776
87MP0002896_abnormal_bone_mineralization0.98341390
88MP0003329_amyloid_beta_deposits0.97368915
89MP0000003_abnormal_adipose_tissue0.97331969
90MP0010630_abnormal_cardiac_muscle0.97109132
91MP0009384_cardiac_valve_regurgitation0.96563375
92MP0005248_abnormal_Harderian_gland0.96371755
93MP0010234_abnormal_vibrissa_follicle0.95945071
94MP0009703_decreased_birth_body0.95696394
95MP0003861_abnormal_nervous_system0.95417220
96MP0001346_abnormal_lacrimal_gland0.94905537
97MP0002111_abnormal_tail_morphology0.93871843
98MP0000467_abnormal_esophagus_morphology0.93830135
99MP0002080_prenatal_lethality0.93752237
100MP0003634_abnormal_glial_cell0.93686679
101MP0000767_abnormal_smooth_muscle0.92916145
102MP0010307_abnormal_tumor_latency0.92897094
103MP0009672_abnormal_birth_weight0.91864096
104MP0009250_abnormal_appendicular_skeleto0.91307926
105MP0010368_abnormal_lymphatic_system0.91096426
106MP0005621_abnormal_cell_physiology0.90813651
107MP0004130_abnormal_muscle_cell0.90442599
108MP0000750_abnormal_muscle_regeneration0.90175869
109MP0005375_adipose_tissue_phenotype0.89787649
110MP0005367_renal/urinary_system_phenotyp0.89645426
111MP0000516_abnormal_urinary_system0.89645426
112MP0004087_abnormal_muscle_fiber0.88670442
113MP0004264_abnormal_extraembryonic_tissu0.87852658
114MP0002114_abnormal_axial_skeleton0.87697275
115MP0001614_abnormal_blood_vessel0.87453686
116MP0002295_abnormal_pulmonary_circulatio0.86520331
117MP0002234_abnormal_pharynx_morphology0.86316551
118MP0004957_abnormal_blastocyst_morpholog0.85467630
119MP0003448_altered_tumor_morphology0.85400830
120MP0000266_abnormal_heart_morphology0.84064791
121MP0000049_abnormal_middle_ear0.83873583
122MP0003111_abnormal_nucleus_morphology0.83806891
123MP0000462_abnormal_digestive_system0.83712818
124MP0008961_abnormal_basal_metabolism0.83237907
125MP0003879_abnormal_hair_cell0.82075675
126MP0002108_abnormal_muscle_morphology0.81669648
127MP0009780_abnormal_chondrocyte_physiolo0.81539693
128MP0000759_abnormal_skeletal_muscle0.80158584
129MP0010771_integument_phenotype0.80097432
130MP0001784_abnormal_fluid_regulation0.79938037
131MP0008877_abnormal_DNA_methylation0.79730530
132MP0001270_distended_abdomen0.79489912
133MP0002233_abnormal_nose_morphology0.78814775
134MP0000681_abnormal_thyroid_gland0.77710900
135MP0004808_abnormal_hematopoietic_stem0.76022456

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)4.31915721
2Premature rupture of membranes (HP:0001788)4.24846464
3Protrusio acetabuli (HP:0003179)4.16380755
4Cerebral aneurysm (HP:0004944)3.25999337
5Genu recurvatum (HP:0002816)3.04246276
6Broad face (HP:0000283)2.98663938
7Distal upper limb amyotrophy (HP:0007149)2.85766088
8Upper limb amyotrophy (HP:0009129)2.85766088
9Ankle contracture (HP:0006466)2.75729478
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.69502151
11Short 4th metacarpal (HP:0010044)2.69502151
12Bladder diverticulum (HP:0000015)2.68413010
13Hand muscle atrophy (HP:0009130)2.63790434
14Dysmetric saccades (HP:0000641)2.49465936
15Atrophic scars (HP:0001075)2.43000810
16Ulnar bowing (HP:0003031)2.42272850
17Distal lower limb amyotrophy (HP:0008944)2.34654934
18Broad metatarsal (HP:0001783)2.31158743
19Mitral valve prolapse (HP:0001634)2.30382555
20Mitral regurgitation (HP:0001653)2.28778826
21Hyperacusis (HP:0010780)2.28750682
22Elfin facies (HP:0004428)2.27258525
23Broad thumb (HP:0011304)2.26854081
24Cervical subluxation (HP:0003308)2.23285580
25Renovascular hypertension (HP:0100817)2.22534530
26Renal duplication (HP:0000075)2.21643682
27Neonatal hypoglycemia (HP:0001998)2.21239624
28Abnormality of the 4th metacarpal (HP:0010012)2.18656704
29Long palpebral fissure (HP:0000637)2.17144932
30Deviation of the hallux (HP:0010051)2.17010855
31Fused cervical vertebrae (HP:0002949)2.16755436
32Peritonitis (HP:0002586)2.15240033
33Difficulty climbing stairs (HP:0003551)2.15233795
34Hallux valgus (HP:0001822)2.13000958
35Abnormality of the aortic arch (HP:0012303)2.12429037
36Vertebral compression fractures (HP:0002953)2.12137550
37Dilatation of the ascending aorta (HP:0005111)2.11414257
38Abnormality of the fingertips (HP:0001211)2.11364183
39Aplasia involving bones of the upper limbs (HP:0009823)2.10519734
40Aplasia of the phalanges of the hand (HP:0009802)2.10519734
41Aplasia involving bones of the extremities (HP:0009825)2.10519734
42Neonatal short-limb short stature (HP:0008921)2.09841236
43Turricephaly (HP:0000262)2.08885280
44Coronal craniosynostosis (HP:0004440)2.06333176
45Advanced eruption of teeth (HP:0006288)2.06151461
46Patellar dislocation (HP:0002999)2.04497190
47Lower limb amyotrophy (HP:0007210)2.04436927
48Hyperextensible skin (HP:0000974)2.04058803
49Bronchomalacia (HP:0002780)2.03052876
50Abnormality of the distal phalanx of the thumb (HP:0009617)2.00207437
51Stridor (HP:0010307)1.99439247
52Pointed chin (HP:0000307)1.99225878
53Bowel diverticulosis (HP:0005222)1.98801395
54Natal tooth (HP:0000695)1.97211980
55Aneurysm (HP:0002617)1.96912100
56Premature skin wrinkling (HP:0100678)1.96438295
57Fragile skin (HP:0001030)1.95896703
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93546024
59Short phalanx of the thumb (HP:0009660)1.93525755
60Aortic dissection (HP:0002647)1.93309149
61Short humerus (HP:0005792)1.92617914
62Male infertility (HP:0003251)1.91692855
63Increased connective tissue (HP:0009025)1.90763253
64Spinal rigidity (HP:0003306)1.90066221
65Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.89536840
66Short 1st metacarpal (HP:0010034)1.89536840
67Dislocated radial head (HP:0003083)1.88779467
68Hypoventilation (HP:0002791)1.88295607
69Arnold-Chiari malformation (HP:0002308)1.87421556
70Buphthalmos (HP:0000557)1.87095344
71Broad distal phalanx of finger (HP:0009836)1.86608916
72Abnormality of the Achilles tendon (HP:0005109)1.85572293
73Biconcave vertebral bodies (HP:0004586)1.85560403
74Abnormality of the radial head (HP:0003995)1.84621575
75Overriding aorta (HP:0002623)1.83717138
76Macroorchidism (HP:0000053)1.82837221
77Obstructive sleep apnea (HP:0002870)1.82412193
78Supernumerary ribs (HP:0005815)1.82364847
79Blue sclerae (HP:0000592)1.81553986
80Flat acetabular roof (HP:0003180)1.80591846
81Esophageal atresia (HP:0002032)1.79758113
82Short nail (HP:0001799)1.79030789
83Broad phalanges of the hand (HP:0009768)1.78880968
84Persistence of primary teeth (HP:0006335)1.78476177
85Aplasia/hypoplasia of the humerus (HP:0006507)1.76812053
86Annular pancreas (HP:0001734)1.76042402
87Achilles tendon contracture (HP:0001771)1.75942356
88Abnormality of the distal phalanges of the toes (HP:0010182)1.75729300
89Genetic anticipation (HP:0003743)1.75662486
90Abnormality of the astrocytes (HP:0100707)1.75472259
91Astrocytoma (HP:0009592)1.75472259
92Neoplasm of the heart (HP:0100544)1.74258987
93Increased variability in muscle fiber diameter (HP:0003557)1.73449679
94Precocious puberty (HP:0000826)1.72162478
95Wrist flexion contracture (HP:0001239)1.71895888
96Abnormality of dentin (HP:0010299)1.71542258
97Selective tooth agenesis (HP:0001592)1.70998810
98Vertebral fusion (HP:0002948)1.70671205
99Trismus (HP:0000211)1.70147676
100Abnormality of the phalanges of the hallux (HP:0010057)1.70038241
101Arterial tortuosity (HP:0005116)1.69735957
102Broad long bones (HP:0005622)1.69164974
103Thin ribs (HP:0000883)1.69051867
104Disproportionate tall stature (HP:0001519)1.69003726
105Aortic aneurysm (HP:0004942)1.68977692
106Atelectasis (HP:0100750)1.68649944
107Vascular tortuosity (HP:0004948)1.68399986
108Trigonocephaly (HP:0000243)1.68294539
109Truncus arteriosus (HP:0001660)1.68266366
110Broad toe (HP:0001837)1.68135339
111Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.67219851
112Heterotopia (HP:0002282)1.67214641
113Acanthosis nigricans (HP:0000956)1.66709093
114Broad finger (HP:0001500)1.66020917
115Bowed forearm bones (HP:0003956)1.65928281
116Bowing of the arm (HP:0006488)1.65928281
117Abnormality of the musculature of the hand (HP:0001421)1.65756044
118Deviation of the thumb (HP:0009603)1.65444769
119Wide anterior fontanel (HP:0000260)1.64980579
120Hyporeflexia of lower limbs (HP:0002600)1.63055429
121Wormian bones (HP:0002645)1.62879418
122Fibroma (HP:0010614)1.62199119
123Milia (HP:0001056)1.61646458
124Pseudobulbar signs (HP:0002200)1.60540299
125Urethral obstruction (HP:0000796)1.60341457
126Broad phalanx (HP:0006009)1.60291291
127Missing ribs (HP:0000921)1.60104045
128Flat cornea (HP:0007720)1.60024027
129Broad hallux (HP:0010055)1.59819092
130Congenital glaucoma (HP:0001087)1.59699930
131Increased nuchal translucency (HP:0010880)1.58910387
132Abnormality of the 1st metacarpal (HP:0010009)1.58439741
133Rectal prolapse (HP:0002035)1.58409174
134Cerebral inclusion bodies (HP:0100314)1.58385707
135Ependymoma (HP:0002888)1.58377121
136Soft skin (HP:0000977)1.58165545
137Insomnia (HP:0100785)1.57967617
138Segmental peripheral demyelination/remyelination (HP:0003481)1.57886958
139Thin bony cortex (HP:0002753)1.57696351
140Mildly elevated creatine phosphokinase (HP:0008180)1.57213699
141Scapular winging (HP:0003691)1.56911721
142Long eyelashes (HP:0000527)1.56704129
143Joint laxity (HP:0001388)1.56484176
144Rib fusion (HP:0000902)1.54869440

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.72566995
2CDK124.15600647
3TRIB33.82115376
4PRKD33.46801409
5SMG12.93632910
6MAP3K102.70990616
7IRAK32.58657053
8TYRO32.32380883
9LATS22.22594060
10EPHA22.21926976
11LATS12.17158593
12PKN22.10649335
13PDGFRA2.09938714
14EEF2K2.05405829
15TESK12.02730633
16PRPF4B2.00334032
17BMX1.94252053
18ERN11.91757196
19EPHB11.83481336
20MTOR1.76150100
21DMPK1.74645865
22RIPK11.71853623
23DDR21.59817490
24TTN1.49731432
25PTK21.49452027
26PTK61.47850147
27ALK1.46813232
28MET1.36996409
29FGFR41.33422722
30PAK41.32319720
31EPHB21.25840058
32PAK21.24599671
33NEK21.24457702
34MST1R1.20567347
35TAOK11.19652793
36CAMK1G1.17594460
37STK101.13916340
38STK31.13788031
39SIK21.11259091
40LMTK21.10274578
41TAOK21.07521566
42DYRK1B1.07084304
43PNCK1.02319782
44PAK61.00421554
45PDGFRB0.98989131
46MAP3K70.96830306
47SCYL20.96173780
48SIK10.94687281
49RPS6KA20.90784617
50STK380.90659546
51BRD40.88908348
52PDPK10.86510995
53CDK60.84887124
54IRAK20.83773320
55MAP3K30.83758716
56LRRK20.82825180
57TESK20.80785481
58CAMK1D0.79649606
59WNK10.79072764
60CDK80.78597529
61NTRK10.78229337
62PTK2B0.78218991
63FGFR10.77412363
64FER0.75702933
65MAP3K80.74589123
66MAP3K90.74456512
67KSR20.72113821
68CDK70.68225629
69PRKD20.67560868
70TTK0.67491496
71NME20.66515207
72MARK20.65490969
73RET0.65025349
74CDK40.64113053
75EPHA30.62914817
76STK390.62318062
77PAK10.61883950
78RPS6KL10.60992739
79RPS6KC10.60992739
80WNK40.60827711
81CAMKK10.59413023
82ILK0.58235251
83STK110.57924743
84MAP3K130.57316139
85MAP2K20.55344202
86RPS6KA60.55175010
87FGFR20.54957734
88CHUK0.53588604
89MAP3K110.52806580
90SGK30.52190631
91PAK30.51920961
92RPS6KA40.49750146
93CDC42BPA0.49244956
94NTRK30.49188006
95MAPK110.48704135
96CHEK10.47947343
97PRKD10.46163928
98ROCK20.46029989
99MAPK10.43753294
100MAP2K30.43529705
101CDK20.43184371
102RPS6KA10.42244920
103HIPK20.41918025
104GSK3A0.41819743
105RPS6KB20.39345352
106CDC70.39279866
107MAP3K60.39164153
108UHMK10.38328405
109MAP3K20.38127211
110ROCK10.37592732
111MAPK100.37469356
112MAP3K10.37353608
113PDK10.36420777
114ERBB20.36323889
115STK38L0.34973209
116MAPK150.34186118
117PRKG20.34177312
118MELK0.34044439
119CDK140.33823467
120EGFR0.33203402
121FGFR30.32137333
122CDK90.32119510
123PRKCH0.31984949
124INSR0.31348124
125BRAF0.31301517
126PRKAA10.30993243
127GSK3B0.30902074
128MAPK80.30784257
129IRAK10.30691428
130CSK0.30422366
131LIMK10.30375519
132MAPKAPK20.30022415
133CSNK1E0.29888051
134CAMK10.28014488
135DAPK20.26511972
136AKT10.26060229
137AKT30.25877115
138CAMK40.25515535

Predicted pathways (KEGG)

RankGene SetZ-score
1Hippo signaling pathway_Homo sapiens_hsa043902.10396191
2Adherens junction_Homo sapiens_hsa045201.98708826
3Basal cell carcinoma_Homo sapiens_hsa052171.94569561
4Hedgehog signaling pathway_Homo sapiens_hsa043401.92753149
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.89291302
6Proteoglycans in cancer_Homo sapiens_hsa052051.82511812
7Chronic myeloid leukemia_Homo sapiens_hsa052201.81243591
8Focal adhesion_Homo sapiens_hsa045101.81134836
9ECM-receptor interaction_Homo sapiens_hsa045121.78200307
10MicroRNAs in cancer_Homo sapiens_hsa052061.75993816
11Bladder cancer_Homo sapiens_hsa052191.72081104
12Renal cell carcinoma_Homo sapiens_hsa052111.68013218
13Notch signaling pathway_Homo sapiens_hsa043301.67038008
14Small cell lung cancer_Homo sapiens_hsa052221.66106287
15Dorso-ventral axis formation_Homo sapiens_hsa043201.65005299
16Tight junction_Homo sapiens_hsa045301.59610075
17mTOR signaling pathway_Homo sapiens_hsa041501.54160844
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43414295
19Glioma_Homo sapiens_hsa052141.39286747
20Regulation of actin cytoskeleton_Homo sapiens_hsa048101.35623878
21TGF-beta signaling pathway_Homo sapiens_hsa043501.35413383
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34705001
23Amoebiasis_Homo sapiens_hsa051461.33379513
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32735367
25Prostate cancer_Homo sapiens_hsa052151.31549173
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30898609
27VEGF signaling pathway_Homo sapiens_hsa043701.30883699
28Endometrial cancer_Homo sapiens_hsa052131.27701801
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25036748
30Axon guidance_Homo sapiens_hsa043601.24947700
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21367461
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.20943253
33mRNA surveillance pathway_Homo sapiens_hsa030151.20272926
34Estrogen signaling pathway_Homo sapiens_hsa049151.19520292
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.18303338
36Pancreatic cancer_Homo sapiens_hsa052121.14637438
37Endocytosis_Homo sapiens_hsa041441.13918709
38Wnt signaling pathway_Homo sapiens_hsa043101.13288745
39Colorectal cancer_Homo sapiens_hsa052101.12599666
40Acute myeloid leukemia_Homo sapiens_hsa052211.10966717
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10506997
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08773747
43Shigellosis_Homo sapiens_hsa051311.07323886
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05557725
45ErbB signaling pathway_Homo sapiens_hsa040121.05497442
46HTLV-I infection_Homo sapiens_hsa051661.04751309
47Pathways in cancer_Homo sapiens_hsa052001.04577439
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04329414
49Dilated cardiomyopathy_Homo sapiens_hsa054141.03000686
50Viral myocarditis_Homo sapiens_hsa054161.02472612
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99556795
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99489288
53Long-term potentiation_Homo sapiens_hsa047200.97740273
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.97433387
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95903879
56Non-small cell lung cancer_Homo sapiens_hsa052230.95374597
57Toxoplasmosis_Homo sapiens_hsa051450.95231589
58Inositol phosphate metabolism_Homo sapiens_hsa005620.94577998
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.94129438
60RNA transport_Homo sapiens_hsa030130.94106197
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.93405379
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93338284
63AMPK signaling pathway_Homo sapiens_hsa041520.93098503
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93069859
65Melanogenesis_Homo sapiens_hsa049160.92365061
66Other glycan degradation_Homo sapiens_hsa005110.92329420
67Rap1 signaling pathway_Homo sapiens_hsa040150.91901795
68Melanoma_Homo sapiens_hsa052180.90289010
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89329081
70Insulin resistance_Homo sapiens_hsa049310.89219703
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.88571313
72Protein digestion and absorption_Homo sapiens_hsa049740.87456408
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87394837
74MAPK signaling pathway_Homo sapiens_hsa040100.87102720
75Thyroid cancer_Homo sapiens_hsa052160.86290686
76Salmonella infection_Homo sapiens_hsa051320.85444606
77Oocyte meiosis_Homo sapiens_hsa041140.84969527
78Lysine degradation_Homo sapiens_hsa003100.81938947
79Type II diabetes mellitus_Homo sapiens_hsa049300.81857381
80Viral carcinogenesis_Homo sapiens_hsa052030.80799923
81Cell cycle_Homo sapiens_hsa041100.78768211
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.78653983
83HIF-1 signaling pathway_Homo sapiens_hsa040660.77338338
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76530454
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76279359
86Glucagon signaling pathway_Homo sapiens_hsa049220.76089988
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75319141
88Cholinergic synapse_Homo sapiens_hsa047250.73491418
89p53 signaling pathway_Homo sapiens_hsa041150.72771196
90Gastric acid secretion_Homo sapiens_hsa049710.72147044
91TNF signaling pathway_Homo sapiens_hsa046680.71835036
92Synaptic vesicle cycle_Homo sapiens_hsa047210.71047417
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70479297
94Prolactin signaling pathway_Homo sapiens_hsa049170.70185014
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70103837
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69973123
97Gap junction_Homo sapiens_hsa045400.69939373
98Hepatitis C_Homo sapiens_hsa051600.69928424
99FoxO signaling pathway_Homo sapiens_hsa040680.68951900
100Choline metabolism in cancer_Homo sapiens_hsa052310.68399889
101Insulin secretion_Homo sapiens_hsa049110.67451691
102cAMP signaling pathway_Homo sapiens_hsa040240.66377642
103Cocaine addiction_Homo sapiens_hsa050300.65756118
104Thyroid hormone synthesis_Homo sapiens_hsa049180.65354903
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.65249140
106Ras signaling pathway_Homo sapiens_hsa040140.65122187
107Apoptosis_Homo sapiens_hsa042100.65019874
108Insulin signaling pathway_Homo sapiens_hsa049100.64036460
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.63442566
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61685402
111GnRH signaling pathway_Homo sapiens_hsa049120.61209413
112Hepatitis B_Homo sapiens_hsa051610.60315230
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58624959
114Prion diseases_Homo sapiens_hsa050200.56903026
115Osteoclast differentiation_Homo sapiens_hsa043800.56881485
116B cell receptor signaling pathway_Homo sapiens_hsa046620.56785854
117Oxytocin signaling pathway_Homo sapiens_hsa049210.56000951
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55883708
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55647419
120Platelet activation_Homo sapiens_hsa046110.55515981

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