SAMD11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)9.81931026
2GMP metabolic process (GO:0046037)9.26201852
3phototransduction (GO:0007602)8.41486693
4detection of light stimulus involved in sensory perception (GO:0050962)8.40524101
5detection of light stimulus involved in visual perception (GO:0050908)8.40524101
6detection of light stimulus (GO:0009583)8.14316546
7eye photoreceptor cell differentiation (GO:0001754)7.95996590
8photoreceptor cell differentiation (GO:0046530)7.95996590
9phototransduction, visible light (GO:0007603)7.81130148
10visual perception (GO:0007601)7.69485895
11detection of visible light (GO:0009584)7.64625699
12sensory perception of light stimulus (GO:0050953)7.61864907
13retina development in camera-type eye (GO:0060041)6.81852364
14positive regulation of guanylate cyclase activity (GO:0031284)6.35816075
15cellular response to light stimulus (GO:0071482)5.93512800
16regulation of guanylate cyclase activity (GO:0031282)5.82976710
17detection of external stimulus (GO:0009581)5.77818431
18detection of abiotic stimulus (GO:0009582)5.69354793
19protein-chromophore linkage (GO:0018298)5.39378621
20nonmotile primary cilium assembly (GO:0035058)5.37752539
21ribosomal small subunit biogenesis (GO:0042274)4.87349596
22DNA replication checkpoint (GO:0000076)4.74332673
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.43249263
24regulation of cGMP metabolic process (GO:0030823)4.42088181
25retina layer formation (GO:0010842)4.39689850
26protein localization to synapse (GO:0035418)4.24262576
27protoporphyrinogen IX metabolic process (GO:0046501)4.23662748
28cellular response to radiation (GO:0071478)4.03232967
29muscle cell fate commitment (GO:0042693)3.98284978
30GDP-mannose metabolic process (GO:0019673)3.97948328
31outflow tract septum morphogenesis (GO:0003148)3.95933578
32protoporphyrinogen IX biosynthetic process (GO:0006782)3.93950245
33sensory perception (GO:0007600)3.92606806
34neuron development (GO:0048666)3.85179062
35negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.74506904
36adaptation of signaling pathway (GO:0023058)3.73921277
37regulation of glucocorticoid metabolic process (GO:0031943)3.72135603
38embryonic skeletal joint morphogenesis (GO:0060272)3.71660286
39cell morphogenesis involved in neuron differentiation (GO:0048667)3.70339779
40positive regulation of cGMP biosynthetic process (GO:0030828)3.66159673
41regulation of cardioblast proliferation (GO:0003264)3.64151827
42regulation of secondary heart field cardioblast proliferation (GO:0003266)3.64151827
43outer ear morphogenesis (GO:0042473)3.61859693
44positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.57979007
45regulation of short-term neuronal synaptic plasticity (GO:0048172)3.57936646
46peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.57474219
47regulation of clathrin-mediated endocytosis (GO:2000369)3.50770224
48diaphragm development (GO:0060539)3.50422630
49regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.50193635
50regulation of mammary gland epithelial cell proliferation (GO:0033599)3.49448557
51short-term memory (GO:0007614)3.49212162
52regulation of cGMP biosynthetic process (GO:0030826)3.48849862
53protein heterotetramerization (GO:0051290)3.45292626
54lymph vessel development (GO:0001945)3.44927620
55rRNA modification (GO:0000154)3.42569583
56folic acid metabolic process (GO:0046655)3.42447184
57peptidyl-arginine omega-N-methylation (GO:0035247)3.40213389
58regulation of nuclear cell cycle DNA replication (GO:0033262)3.38934192
59regulation of translational fidelity (GO:0006450)3.38472674
60cranial nerve morphogenesis (GO:0021602)3.33885650
61viral transcription (GO:0019083)3.33168488
62embryonic heart tube development (GO:0035050)3.31778480
63rRNA methylation (GO:0031167)3.31765278
64positive regulation of cGMP metabolic process (GO:0030825)3.31712245
65pseudouridine synthesis (GO:0001522)3.31631105
66axoneme assembly (GO:0035082)3.31047360
67negative regulation of cell aging (GO:0090344)3.23611601
68tooth mineralization (GO:0034505)3.22493312
69dorsal/ventral neural tube patterning (GO:0021904)3.22083269
70response to light stimulus (GO:0009416)3.21224252
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18017071
72ribonucleoprotein complex biogenesis (GO:0022613)3.17422834
73translational termination (GO:0006415)3.17290341
74righting reflex (GO:0060013)3.16411013
75presynaptic membrane assembly (GO:0097105)3.15915797
76mammary gland epithelial cell differentiation (GO:0060644)3.14550319
77skeletal muscle organ development (GO:0060538)3.14240892
78positive regulation of neurotransmitter transport (GO:0051590)3.13580795
79positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.13328558
80regulation of cardioblast differentiation (GO:0051890)3.09086455
81rRNA transcription (GO:0009303)3.08857205
82negative regulation of receptor-mediated endocytosis (GO:0048261)3.07327440
83regulation of voltage-gated calcium channel activity (GO:1901385)3.06732556
84atrial septum morphogenesis (GO:0060413)3.04223437
85regulation of heart morphogenesis (GO:2000826)3.02268864
86regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.00393453
87translational elongation (GO:0006414)2.99369283
88DNA strand renaturation (GO:0000733)2.98026193
89negative regulation of transcription regulatory region DNA binding (GO:2000678)2.96841657
90pharyngeal system development (GO:0060037)2.96112288
91receptor guanylyl cyclase signaling pathway (GO:0007168)2.94903159
92regulation of mitochondrial translation (GO:0070129)2.94074955
93regulation of apoptotic process involved in morphogenesis (GO:1902337)2.93863834
94protein prenylation (GO:0018342)2.92314431
95prenylation (GO:0097354)2.92314431
96protein localization to cilium (GO:0061512)2.91145991
97rRNA processing (GO:0006364)2.90147417
98proline biosynthetic process (GO:0006561)2.89411430
99histone arginine methylation (GO:0034969)2.89240900
100porphyrin-containing compound biosynthetic process (GO:0006779)2.89075314
101maturation of SSU-rRNA (GO:0030490)2.88243276
102peptidyl-histidine modification (GO:0018202)2.87713194
103membrane hyperpolarization (GO:0060081)2.87475983
104embryonic forelimb morphogenesis (GO:0035115)2.86421788
105retina homeostasis (GO:0001895)2.85926349
106middle ear morphogenesis (GO:0042474)2.85821445
107regulation of translational termination (GO:0006449)2.85271870
108neuron fate specification (GO:0048665)2.85145279
109thyroid gland development (GO:0030878)2.84491268
110heme biosynthetic process (GO:0006783)2.84123589
111UTP biosynthetic process (GO:0006228)2.83566662
112SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.82071435
113ribosomal large subunit biogenesis (GO:0042273)2.81833449
114peptidyl-arginine N-methylation (GO:0035246)2.81218923
115peptidyl-arginine methylation (GO:0018216)2.81218923
116ribosome biogenesis (GO:0042254)2.81151484
117pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.78876104
118appendage development (GO:0048736)2.78065858
119limb development (GO:0060173)2.78065858
120coronary vasculature morphogenesis (GO:0060977)2.77518088
121peripheral nervous system neuron development (GO:0048935)2.76827598
122rRNA metabolic process (GO:0016072)2.76687783
123pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.76609792
124heterochromatin organization (GO:0070828)2.76039775
125tetrapyrrole biosynthetic process (GO:0033014)2.75297682
126hemoglobin metabolic process (GO:0020027)2.75207742
127cotranslational protein targeting to membrane (GO:0006613)2.73874350
128protein targeting to ER (GO:0045047)2.72450470
129postsynaptic membrane organization (GO:0001941)2.71583845
130estrogen biosynthetic process (GO:0006703)2.69579665
131cellular component biogenesis (GO:0044085)2.67290988
132embryonic skeletal system morphogenesis (GO:0048704)2.66562547
133behavioral response to ethanol (GO:0048149)2.66489948
134guanosine-containing compound biosynthetic process (GO:1901070)2.66179034
135chromatin assembly (GO:0031497)2.65867807
136CTP biosynthetic process (GO:0006241)2.65320959
137CTP metabolic process (GO:0046036)2.65320959
138GTP biosynthetic process (GO:0006183)2.64754419
139regulation of cell aging (GO:0090342)2.63694282
140viral mRNA export from host cell nucleus (GO:0046784)2.62756174
141establishment of protein localization to endoplasmic reticulum (GO:0072599)2.61170909
142oxidative phosphorylation (GO:0006119)2.60187480
143synaptic vesicle maturation (GO:0016188)2.59345625
144DNA replication initiation (GO:0006270)2.59267373
145startle response (GO:0001964)2.59261537
146proximal/distal pattern formation (GO:0009954)2.58910807
147erythrocyte maturation (GO:0043249)2.58051380
148regulation of translational elongation (GO:0006448)2.55939504
149protein localization to endoplasmic reticulum (GO:0070972)2.55741675
150nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.55734296
151tRNA modification (GO:0006400)2.55378470
152pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.55317592
153translational initiation (GO:0006413)2.54245366
154cellular response to ATP (GO:0071318)2.53853289
155negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.52849301
156positive regulation of membrane potential (GO:0045838)2.52475042
157pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.51630348
158UTP metabolic process (GO:0046051)2.51259356
159response to pheromone (GO:0019236)2.51191337
160viral life cycle (GO:0019058)2.51101049
161presynaptic membrane organization (GO:0097090)2.50303172
162negative regulation of T cell differentiation in thymus (GO:0033085)2.49907815
163regulation of organ formation (GO:0003156)2.48861722
164protein K6-linked ubiquitination (GO:0085020)2.47512558
165forelimb morphogenesis (GO:0035136)2.45764375
166cochlea morphogenesis (GO:0090103)2.45603674
167transcription from mitochondrial promoter (GO:0006390)2.45579167
168regulation of vesicle fusion (GO:0031338)2.45300031
169mitochondrial RNA metabolic process (GO:0000959)2.45290820
170positive regulation of neurotransmitter secretion (GO:0001956)2.43849889
171muscle organ morphogenesis (GO:0048644)2.42917729
172DNA strand elongation involved in DNA replication (GO:0006271)2.42745705
173DNA strand elongation (GO:0022616)2.41549091
174positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.41217553
175translation (GO:0006412)2.41170841
176chemosensory behavior (GO:0007635)2.40278102
177cellular protein complex disassembly (GO:0043624)2.38410515
178detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.36693652
179response to radiation (GO:0009314)2.30014557
180response to histamine (GO:0034776)2.29954466
181neuron cell-cell adhesion (GO:0007158)2.29653812
182regulation of transcription regulatory region DNA binding (GO:2000677)2.29586985
183histone H3-K4 trimethylation (GO:0080182)2.28627637
184regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.24216613
185regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.24216613
186regulation of penile erection (GO:0060405)2.23639450
187regulation of neurotransmitter secretion (GO:0046928)2.22150689
188behavioral response to nicotine (GO:0035095)2.20118462
189positive regulation of vesicle fusion (GO:0031340)2.17467581
190porphyrin-containing compound metabolic process (GO:0006778)2.16758580
191microtubule depolymerization (GO:0007019)2.15950547
192heme metabolic process (GO:0042168)2.15312923
193cilium organization (GO:0044782)2.15097536
194regulation of dopamine metabolic process (GO:0042053)2.13652867
195regulation of rhodopsin mediated signaling pathway (GO:0022400)14.1340517
196rhodopsin mediated signaling pathway (GO:0016056)13.6691724
197photoreceptor cell development (GO:0042461)11.6701058
198photoreceptor cell maintenance (GO:0045494)11.5811288
199retinal cone cell development (GO:0046549)11.4898183
200eye photoreceptor cell development (GO:0042462)11.1576549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.48927502
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.96551007
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.28168788
4XRN2_22483619_ChIP-Seq_HELA_Human3.04441434
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.00350898
6E2F7_22180533_ChIP-Seq_HELA_Human3.00219111
7GBX2_23144817_ChIP-Seq_PC3_Human2.98104221
8CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.94218536
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83561354
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.80786492
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63727209
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54239739
13KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.51574403
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.42624432
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.38596205
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36765085
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.35211083
18IGF1R_20145208_ChIP-Seq_DFB_Human2.30428315
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.29987260
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.28726656
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27374791
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26280737
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.23109193
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22513362
25VDR_22108803_ChIP-Seq_LS180_Human2.22463776
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.21489950
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.19992184
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.19127594
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19126801
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.11888357
31MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06113433
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05824080
33IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05772705
34DCP1A_22483619_ChIP-Seq_HELA_Human2.04894930
35CBX2_27304074_Chip-Seq_ESCs_Mouse2.04748695
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04375142
37VDR_21846776_ChIP-Seq_THP-1_Human2.02554006
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01412739
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.96916545
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96528755
41TTF2_22483619_ChIP-Seq_HELA_Human1.94594102
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93734416
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92640026
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90086225
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90086225
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89953664
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89696732
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88713999
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.83442724
50GABP_19822575_ChIP-Seq_HepG2_Human1.83025933
51* LXR_22292898_ChIP-Seq_THP-1_Human1.82285117
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81497078
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.81068313
54* RACK7_27058665_Chip-Seq_MCF-7_Human1.77824594
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75752446
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.72614978
57MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72440279
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72043774
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70089508
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.69980504
61REST_21632747_ChIP-Seq_MESCs_Mouse1.69628485
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.69367938
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67869134
64* P68_20966046_ChIP-Seq_HELA_Human1.66519929
65KDM5A_27292631_Chip-Seq_BREAST_Human1.65031244
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.61369068
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60952076
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.60272049
69ZNF263_19887448_ChIP-Seq_K562_Human1.60208686
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54549704
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54010348
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.53848418
73SCL_19346495_ChIP-Seq_HPC-7_Human1.50951995
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50143209
75FOXP1_21924763_ChIP-Seq_HESCs_Human1.49819131
76RNF2_27304074_Chip-Seq_NSC_Mouse1.47875493
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47310372
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47066474
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.46330984
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44997083
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.42876315
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.41580295
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41060111
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40884450
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39397494
86GATA1_19941826_ChIP-Seq_K562_Human1.38844903
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38469240
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37773062
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37433804
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37398470
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37141361
92RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36407650
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36353041
94CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33411011
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.33190397
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32931827
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.31051228
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30955166
99MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30732667
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30338628
101NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28685297
102SOX2_16153702_ChIP-ChIP_HESCs_Human1.28054172
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.27379808
104P300_19829295_ChIP-Seq_ESCs_Human1.26915872
105* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.24706101
106* CTCF_27219007_Chip-Seq_Bcells_Human1.23555686
107E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22101032
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21922874
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21736006
110* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21219757
111SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20571350
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19424932
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19418459
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18044939
115CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16698628
116CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16558136
117* CREB1_26743006_Chip-Seq_LNCaP_Human1.15304174
118FLI1_27457419_Chip-Seq_LIVER_Mouse1.14886269
119AR_21572438_ChIP-Seq_LNCaP_Human1.14322623
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.13969183
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13952103
122SA1_27219007_Chip-Seq_ERYTHROID_Human1.13594603
123* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13082358
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12533456
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12118108
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12074590
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10952822
128* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10826695
129NANOG_18555785_Chip-Seq_ESCs_Mouse1.08956803
130CTCF_26484167_Chip-Seq_Bcells_Mouse1.08206166
131MYC_22102868_ChIP-Seq_BL_Human1.08122102
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08061727
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06933746
134FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06294901
135PHF8_20622854_ChIP-Seq_HELA_Human1.06134699
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06047990
137EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05525575
138STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.05506604
139SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05011559
140TAL1_26923725_Chip-Seq_HPCs_Mouse1.04982738
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04311931
142TP63_19390658_ChIP-ChIP_HaCaT_Human1.04230065
143NFE2_27457419_Chip-Seq_LIVER_Mouse1.03858314
144ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03721040
145PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03046837
146YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02911665
147YY1_21170310_ChIP-Seq_MESCs_Mouse1.02695856
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02538928
149DROSHA_22980978_ChIP-Seq_HELA_Human1.02455556
150SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02070329
151RARA_24833708_ChIP-Seq_LIVER_Mouse1.01963861
152SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01955963
153* ERG_21242973_ChIP-ChIP_JURKAT_Human1.01817796
154DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01556481
155HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01553955
156PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01123862
157FUS_26573619_Chip-Seq_HEK293_Human1.01012888
158* KDM2B_26808549_Chip-Seq_K562_Human1.00438880
159RING1B_27294783_Chip-Seq_ESCs_Mouse1.00325951
160HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00315075
161RARB_27405468_Chip-Seq_BRAIN_Mouse0.99903693
162FOXP3_21729870_ChIP-Seq_TREG_Human0.99799097
163STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99233483
164OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98828720
165SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97751310
166TAF2_19829295_ChIP-Seq_ESCs_Human0.96652093
167EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95271770
168POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93455154
169TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93455154
170PRDM14_20953172_ChIP-Seq_ESCs_Human0.93106800
171SMAD4_21799915_ChIP-Seq_A2780_Human0.92689898
172* TBL1_22424771_ChIP-Seq_293T_Human0.91679271
173SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89721835
174E2F1_18555785_Chip-Seq_ESCs_Mouse0.88544558
175ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88461868
176EWS_26573619_Chip-Seq_HEK293_Human0.87933375
177NANOG_20526341_ChIP-Seq_ESCs_Human0.87722122
178ER_23166858_ChIP-Seq_MCF-7_Human0.86237774
179TAF15_26573619_Chip-Seq_HEK293_Human0.83612174
180MYC_18940864_ChIP-ChIP_HL60_Human0.81117669
181TCF4_23295773_ChIP-Seq_U87_Human0.80274756
182* CTCF_20526341_ChIP-Seq_ESCs_Human0.79946585
183P53_22387025_ChIP-Seq_ESCs_Mouse0.79403942
184P300_18555785_Chip-Seq_ESCs_Mouse0.78741624

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog8.65765293
2MP0003011_delayed_dark_adaptation8.15864079
3MP0006072_abnormal_retinal_apoptosis6.46497752
4MP0005253_abnormal_eye_physiology6.10834938
5MP0002638_abnormal_pupillary_reflex3.81295103
6MP0005195_abnormal_posterior_eye3.80071255
7MP0003283_abnormal_digestive_organ3.45665904
8MP0001324_abnormal_eye_pigmentation3.34482793
9MP0005623_abnormal_meninges_morphology3.31350281
10MP0002249_abnormal_larynx_morphology3.20286880
11MP0005391_vision/eye_phenotype3.05223213
12MP0006292_abnormal_olfactory_placode2.94123798
13MP0003950_abnormal_plasma_membrane2.70360027
14MP0002229_neurodegeneration2.57332257
15MP0000013_abnormal_adipose_tissue2.52646490
16MP0002234_abnormal_pharynx_morphology2.43692281
17MP0003111_abnormal_nucleus_morphology2.37491462
18MP0002160_abnormal_reproductive_system2.36672195
19MP0003693_abnormal_embryo_hatching2.36309886
20MP0005423_abnormal_somatic_nervous2.36297328
21MP0000678_abnormal_parathyroid_gland2.24129429
22MP0000003_abnormal_adipose_tissue2.19527329
23MP0002752_abnormal_somatic_nervous2.15694581
24MP0002877_abnormal_melanocyte_morpholog2.08235898
25MP0000049_abnormal_middle_ear2.02131359
26MP0000537_abnormal_urethra_morphology2.01335431
27MP0001502_abnormal_circadian_rhythm1.93079768
28MP0009250_abnormal_appendicular_skeleto1.89855953
29MP0002653_abnormal_ependyma_morphology1.89520617
30MP0001986_abnormal_taste_sensitivity1.88580994
31MP0003942_abnormal_urinary_system1.88505967
32MP0004957_abnormal_blastocyst_morpholog1.83976458
33MP0002090_abnormal_vision1.81469879
34MP0003705_abnormal_hypodermis_morpholog1.77104717
35MP0003077_abnormal_cell_cycle1.77004827
36MP0004270_analgesia1.76944334
37MP0001661_extended_life_span1.76270641
38MP0003880_abnormal_central_pattern1.75843827
39MP0005076_abnormal_cell_differentiation1.68995156
40MP0003656_abnormal_erythrocyte_physiolo1.67750048
41MP0003937_abnormal_limbs/digits/tail_de1.66805764
42MP0005394_taste/olfaction_phenotype1.62332791
43MP0005499_abnormal_olfactory_system1.62332791
44MP0008789_abnormal_olfactory_epithelium1.58724771
45MP0002882_abnormal_neuron_morphology1.57033130
46MP0008932_abnormal_embryonic_tissue1.55883331
47MP0010094_abnormal_chromosome_stability1.52909124
48MP0000462_abnormal_digestive_system1.51905057
49MP0000538_abnormal_urinary_bladder1.50596933
50MP0000534_abnormal_ureter_morphology1.50575628
51MP0001764_abnormal_homeostasis1.50293899
52MP0004858_abnormal_nervous_system1.49916823
53MP0003123_paternal_imprinting1.48194131
54MP0000733_abnormal_muscle_development1.47047115
55MP0002932_abnormal_joint_morphology1.40425117
56MP0004147_increased_porphyrin_level1.38798842
57MP0009053_abnormal_anal_canal1.36826164
58MP0003315_abnormal_perineum_morphology1.34673948
59MP0005367_renal/urinary_system_phenotyp1.31391166
60MP0000516_abnormal_urinary_system1.31391166
61MP0008007_abnormal_cellular_replicative1.28467291
62MP0001968_abnormal_touch/_nociception1.27265177
63MP0004185_abnormal_adipocyte_glucose1.24592722
64MP0010307_abnormal_tumor_latency1.20376205
65MP0005503_abnormal_tendon_morphology1.17092121
66MP0005171_absent_coat_pigmentation1.15725007
67MP0003786_premature_aging1.15251715
68MP0001944_abnormal_pancreas_morphology1.15223500
69MP0004233_abnormal_muscle_weight1.12935055
70MP0002272_abnormal_nervous_system1.12367741
71MP0005501_abnormal_skin_physiology1.12145733
72MP0000681_abnormal_thyroid_gland1.11576074
73MP0001486_abnormal_startle_reflex1.11552288
74MP0009379_abnormal_foot_pigmentation1.10974085
75MP0002734_abnormal_mechanical_nocicepti1.09704536
76MP0001270_distended_abdomen1.09119073
77MP0010386_abnormal_urinary_bladder1.08303159
78MP0005389_reproductive_system_phenotype1.07256549
79MP0001919_abnormal_reproductive_system1.06465893
80MP0005197_abnormal_uvea_morphology1.06460237
81MP0002067_abnormal_sensory_capabilities1.05211171
82MP0001188_hyperpigmentation1.03132078
83MP0002085_abnormal_embryonic_tissue1.02432294
84MP0001984_abnormal_olfaction1.01853165
85MP0000350_abnormal_cell_proliferation1.01081615
86MP0002102_abnormal_ear_morphology0.99088020
87MP0001730_embryonic_growth_arrest0.99047599
88MP0002064_seizures0.98719255
89MP0006276_abnormal_autonomic_nervous0.98447240
90MP0003935_abnormal_craniofacial_develop0.98152304
91MP0002114_abnormal_axial_skeleton0.96968143
92MP0004859_abnormal_synaptic_plasticity0.95286652
93MP0002116_abnormal_craniofacial_bone0.94609018
94MP0005220_abnormal_exocrine_pancreas0.94209312
95MP0002111_abnormal_tail_morphology0.94135920
96MP0004885_abnormal_endolymph0.93956904
97MP0003119_abnormal_digestive_system0.93348443
98MP0002736_abnormal_nociception_after0.93344105
99MP0003635_abnormal_synaptic_transmissio0.93025855
100MP0005379_endocrine/exocrine_gland_phen0.91834284
101MP0005375_adipose_tissue_phenotype0.91769981
102MP0009745_abnormal_behavioral_response0.91373508
103MP0001697_abnormal_embryo_size0.91030069
104MP0009780_abnormal_chondrocyte_physiolo0.89918609
105MP0002938_white_spotting0.89742060
106MP0002177_abnormal_outer_ear0.88618614
107MP0005380_embryogenesis_phenotype0.85840647
108MP0001672_abnormal_embryogenesis/_devel0.85840647
109MP0004742_abnormal_vestibular_system0.85455816
110MP0010030_abnormal_orbit_morphology0.85189830
111MP0008438_abnormal_cutaneous_collagen0.84239180
112MP0002084_abnormal_developmental_patter0.82971481
113MP0009046_muscle_twitch0.82791860
114MP0001286_abnormal_eye_development0.82302045
115MP0004142_abnormal_muscle_tone0.81671871
116MP0001963_abnormal_hearing_physiology0.81526781
117MP0001756_abnormal_urination0.80874630
118MP0003755_abnormal_palate_morphology0.80813293
119MP0000762_abnormal_tongue_morphology0.80382370
120MP0004133_heterotaxia0.78324476
121MP0003137_abnormal_impulse_conducting0.78067551
122MP0002092_abnormal_eye_morphology0.77811747
123MP0003385_abnormal_body_wall0.76991141
124MP0003938_abnormal_ear_development0.76572910
125MP0003984_embryonic_growth_retardation0.76279860
126MP0001348_abnormal_lacrimal_gland0.75990533
127MP0000026_abnormal_inner_ear0.74585004
128MP0002080_prenatal_lethality0.73995155
129MP0000778_abnormal_nervous_system0.73938868
130MP0002088_abnormal_embryonic_growth/wei0.73727150
131MP0003634_abnormal_glial_cell0.73513512
132MP0002735_abnormal_chemical_nociception0.73348152
133MP0003136_yellow_coat_color0.72504091
134MP0002210_abnormal_sex_determination0.72468466
135MP0000750_abnormal_muscle_regeneration0.71477248
136MP0003787_abnormal_imprinting0.71233324
137MP0002751_abnormal_autonomic_nervous0.70648150
138MP0000631_abnormal_neuroendocrine_gland0.69973196
139MP0002184_abnormal_innervation0.68931390
140MP0000428_abnormal_craniofacial_morphol0.67372508
141MP0006036_abnormal_mitochondrial_physio0.66117345
142MP0002572_abnormal_emotion/affect_behav0.65743295
143MP0001905_abnormal_dopamine_level0.64893701
144MP0002063_abnormal_learning/memory/cond0.64386169
145MP0002557_abnormal_social/conspecific_i0.63229372
146MP0001346_abnormal_lacrimal_gland0.62390214
147MP0001970_abnormal_pain_threshold0.61299651
148MP0002697_abnormal_eye_size0.58855392
149MP0002127_abnormal_cardiovascular_syste0.58531773
150MP0005409_darkened_coat_color0.56455347
151MP0008058_abnormal_DNA_repair0.53306787
152MP0008004_abnormal_stomach_pH0.52013239
153MP0005386_behavior/neurological_phenoty0.51929191
154MP0004924_abnormal_behavior0.51929191
155MP0005248_abnormal_Harderian_gland0.51627904
156MP0001529_abnormal_vocalization0.49403871
157MP0002066_abnormal_motor_capabilities/c0.43798956
158MP0002152_abnormal_brain_morphology0.42916670
159MP0008872_abnormal_physiological_respon0.42214682
160MP0004811_abnormal_neuron_physiology0.41954132
161MP0004019_abnormal_vitamin_homeostasis0.41704381
162MP0002163_abnormal_gland_morphology0.41606635
163MP0002332_abnormal_exercise_endurance0.40633179
164MP0001293_anophthalmia0.40378489
165MP0001440_abnormal_grooming_behavior0.40201842
166MP0002733_abnormal_thermal_nociception0.39807359
167MP0005645_abnormal_hypothalamus_physiol0.39179734
168MP0001501_abnormal_sleep_pattern0.38988310
169MP0000465_gastrointestinal_hemorrhage0.38894776
170MP0005646_abnormal_pituitary_gland0.38814935
171MP0002277_abnormal_respiratory_mucosa0.37832813
172MP0008569_lethality_at_weaning0.35895027
173MP0005174_abnormal_tail_pigmentation0.35502153
174MP0002822_catalepsy0.35375352
175MP0008260_abnormal_autophagy0.35249284
176MP0004145_abnormal_muscle_electrophysio0.34536623
177MP0004782_abnormal_surfactant_physiolog0.33083155
178MP0000955_abnormal_spinal_cord0.32975866
179MP0005187_abnormal_penis_morphology0.30183816
180MP0008995_early_reproductive_senescence0.30164344
181MP0003698_abnormal_male_reproductive0.29732499
182MP0003861_abnormal_nervous_system0.29695135

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)9.57250528
2Chorioretinal atrophy (HP:0000533)8.94469989
3Pendular nystagmus (HP:0012043)8.87549120
4Pigmentary retinal degeneration (HP:0001146)8.05199899
5Abolished electroretinogram (ERG) (HP:0000550)7.72690234
6Central scotoma (HP:0000603)7.20920670
7Attenuation of retinal blood vessels (HP:0007843)6.66464720
8Severe visual impairment (HP:0001141)6.44289214
9Decreased central vision (HP:0007663)6.40304502
10Abnormality of macular pigmentation (HP:0008002)6.39669762
11Scotoma (HP:0000575)6.18186765
12Dyschromatopsia (HP:0007641)5.96283533
13Increased corneal curvature (HP:0100692)5.62637166
14Keratoconus (HP:0000563)5.62637166
15Type II diabetes mellitus (HP:0005978)5.17217621
16Photophobia (HP:0000613)4.98968228
17Cone-rod dystrophy (HP:0000548)4.97243572
18Macular degeneration (HP:0000608)4.96778121
19Posterior subcapsular cataract (HP:0007787)4.73489316
20Double outlet right ventricle (HP:0001719)4.54532456
21Congenital malformation of the right heart (HP:0011723)4.54532456
22Vitreoretinal degeneration (HP:0000655)4.45979999
23Constricted visual fields (HP:0001133)4.34674666
24Ulnar bowing (HP:0003031)4.08848640
25Retinitis pigmentosa (HP:0000510)3.99323721
26Aplasia/Hypoplasia of the sacrum (HP:0008517)3.58326370
27Testicular atrophy (HP:0000029)3.45682026
28Rectal fistula (HP:0100590)3.36691398
29Rectovaginal fistula (HP:0000143)3.36691398
30Broad distal phalanx of finger (HP:0009836)3.36404197
31Abnormal ventriculo-arterial connection (HP:0011563)3.34021574
32Transposition of the great arteries (HP:0001669)3.34021574
33Abnormal connection of the cardiac segments (HP:0011545)3.34021574
34Abnormal umbilical cord blood vessels (HP:0011403)3.34012376
35Single umbilical artery (HP:0001195)3.34012376
36Abnormality of the fetal cardiovascular system (HP:0010948)3.34012376
37Birth length less than 3rd percentile (HP:0003561)3.23757139
38Unilateral renal agenesis (HP:0000122)3.21971048
39Choroideremia (HP:0001139)3.17158134
40Intestinal fistula (HP:0100819)3.08977795
41Vaginal fistula (HP:0004320)3.08105578
42Abnormality of the phalanges of the hallux (HP:0010057)3.05016095
43Congenital sensorineural hearing impairment (HP:0008527)2.86480544
44Squamous cell carcinoma (HP:0002860)2.86468112
45Rectal prolapse (HP:0002035)2.85017096
46Septate vagina (HP:0001153)2.84127639
47Hyperthyroidism (HP:0000836)2.81529377
48Optic disc pallor (HP:0000543)2.80843056
49Breast hypoplasia (HP:0003187)2.80731660
50Progressive visual loss (HP:0000529)2.80376325
51Abnormality of the aortic arch (HP:0012303)2.80111899
52Hyperinsulinemic hypoglycemia (HP:0000825)2.75052859
53Cutaneous melanoma (HP:0012056)2.67737439
54Abnormality of the umbilical cord (HP:0010881)2.64290395
55Aplasia/Hypoplasia of the patella (HP:0006498)2.63260381
56Microretrognathia (HP:0000308)2.62335136
57Truncus arteriosus (HP:0001660)2.61324867
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.58797647
59Preauricular pit (HP:0004467)2.56826641
60Periauricular skin pits (HP:0100277)2.56826641
61Subcapsular cataract (HP:0000523)2.56679498
62Patellar aplasia (HP:0006443)2.48467792
63Gait imbalance (HP:0002141)2.44218264
64True hermaphroditism (HP:0010459)2.43434658
65Congenital primary aphakia (HP:0007707)2.40117952
66Bowing of the arm (HP:0006488)2.38684758
67Bowed forearm bones (HP:0003956)2.38684758
68Hypoplastic heart (HP:0001961)2.38017443
69Pancreatic fibrosis (HP:0100732)2.30542445
70Hypoplastic left heart (HP:0004383)2.30105873
71Medial flaring of the eyebrow (HP:0010747)2.28752805
72Turricephaly (HP:0000262)2.28682863
73Abnormality of the distal phalanges of the toes (HP:0010182)2.28544054
74Stridor (HP:0010307)2.26222094
75Wide nasal bridge (HP:0000431)2.25111097
76Abnormality of the heme biosynthetic pathway (HP:0010472)2.19736235
77Poikilocytosis (HP:0004447)2.19293409
78Nephrogenic diabetes insipidus (HP:0009806)2.16955838
79Rib fusion (HP:0000902)2.14100055
80Slender long bone (HP:0003100)2.11964916
81Poor coordination (HP:0002370)2.09468841
82Asymmetry of the thorax (HP:0001555)2.08906670
83Genu recurvatum (HP:0002816)2.03494768
84Absent rod-and cone-mediated responses on ERG (HP:0007688)11.5833590
85Congenital stationary night blindness (HP:0007642)11.1326130
86Abnormal rod and cone electroretinograms (HP:0008323)10.5959354
87Short thumb (HP:0009778)1.99943211
88Abnormal number of incisors (HP:0011064)1.97924740
89Coronal craniosynostosis (HP:0004440)1.96206506
90Renal dysplasia (HP:0000110)1.94561037
91Absent radius (HP:0003974)1.91537314
92Carpal synostosis (HP:0009702)1.91071349
93Atresia of the external auditory canal (HP:0000413)1.90619185
94Abnormality of the astrocytes (HP:0100707)1.89838549
95Astrocytoma (HP:0009592)1.89838549
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89440615
97Pancreatic cysts (HP:0001737)1.88455056
98Short middle phalanx of the 5th finger (HP:0004220)1.88325913
99Ketoacidosis (HP:0001993)1.88025271
100Progressive muscle weakness (HP:0003323)1.84082119
101Abnormalities of placenta or umbilical cord (HP:0001194)1.80484568
102Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.80037744
103Sclerocornea (HP:0000647)1.78211174
104Hypokinesia (HP:0002375)1.78162937
105Tetany (HP:0001281)1.77379785
106Deviation of the hallux (HP:0010051)1.76972462
107Redundant skin (HP:0001582)1.76676410
108Absent thumb (HP:0009777)1.76412870
109Amblyopia (HP:0000646)1.76125663
110Increased hepatocellular lipid droplets (HP:0006565)1.74946679
111Aplasia involving forearm bones (HP:0009822)1.74742410
112Absent forearm bone (HP:0003953)1.74742410
113Short clavicles (HP:0000894)1.74721287
114Annular pancreas (HP:0001734)1.74456936
115Abnormality of the distal phalanx of the thumb (HP:0009617)1.72449337
116Lipid accumulation in hepatocytes (HP:0006561)1.71470751
117Vaginal atresia (HP:0000148)1.70402080
118Hallux valgus (HP:0001822)1.69884458
119Renal Fanconi syndrome (HP:0001994)1.69796645
120Short 5th finger (HP:0009237)1.69202596
121Anal atresia (HP:0002023)1.69024057
122Abnormality of the 2nd finger (HP:0004100)1.67473240
123Fragile skin (HP:0001030)1.67214637
124Retinal atrophy (HP:0001105)1.66981293
125Hypoplasia of the radius (HP:0002984)1.66864747
126Genital tract atresia (HP:0001827)1.66418960
127Optic atrophy (HP:0000648)1.66084016
128Abnormality of chromosome segregation (HP:0002916)1.65024868
129Abnormality of the middle phalanges of the toes (HP:0010183)1.64754922
130Renal agenesis (HP:0000104)1.63404350
131Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.62801616
132Hyperacusis (HP:0010780)1.62245602
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.61404629
134Macrocytic anemia (HP:0001972)1.61341911
135Skin pits (HP:0100276)1.59773125
136Aplasia/Hypoplasia of the lens (HP:0008063)1.59253489
137Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.57920209
138Decreased activity of mitochondrial respiratory chain (HP:0008972)1.57920209
139Short humerus (HP:0005792)1.57825266
140Ectopic kidney (HP:0000086)1.57295662
141Abnormality of the tricuspid valve (HP:0001702)1.56112970
142Congenital glaucoma (HP:0001087)1.55298780
143Sparse lateral eyebrow (HP:0005338)1.55138516
144Hypoplasia of the pons (HP:0012110)1.54890804
145Thin bony cortex (HP:0002753)1.54293989
146Nonimmune hydrops fetalis (HP:0001790)1.53690485
147Partial agenesis of the corpus callosum (HP:0001338)1.53272492
148Febrile seizures (HP:0002373)1.50802796
149Epileptic encephalopathy (HP:0200134)1.42834881
150Polar cataract (HP:0010696)1.42459737
151Interstitial pulmonary disease (HP:0006530)1.41927131
152Septo-optic dysplasia (HP:0100842)1.41093367
153Anencephaly (HP:0002323)1.40281246
154Severe Myopia (HP:0011003)1.39875917
155Cystic liver disease (HP:0006706)1.39460939
156Osteomalacia (HP:0002749)1.35004137
157Recurrent sinusitis (HP:0011108)1.33823965
158Aplasia/Hypoplasia of the fovea (HP:0008060)1.33258524
159Hypoplasia of the fovea (HP:0007750)1.33258524
160Horizontal nystagmus (HP:0000666)1.32384589
161Abnormality of dental color (HP:0011073)1.31080920
162Abnormality of midbrain morphology (HP:0002418)1.29729764
163Molar tooth sign on MRI (HP:0002419)1.29729764
164Pallor (HP:0000980)1.27339457
165Chorioretinal coloboma (HP:0000567)1.25569521
166Abnormality of the fovea (HP:0000493)1.24219300
167Abnormality of the septum pellucidum (HP:0007375)1.23589795
168Congenital hepatic fibrosis (HP:0002612)1.19896105
169Nephronophthisis (HP:0000090)1.19549806
170Hypermetropia (HP:0000540)1.15820081
171Astigmatism (HP:0000483)1.13815891
172Reticulocytosis (HP:0001923)1.12759434
173Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.12414758
174Insomnia (HP:0100785)1.11513157
175Postaxial foot polydactyly (HP:0001830)1.09847456
176Abnormality of reticulocytes (HP:0004312)1.07677001
177Abnormal number of erythroid precursors (HP:0012131)1.06219802
178Abnormality of cells of the erythroid lineage (HP:0012130)1.04207228
179Submucous cleft hard palate (HP:0000176)1.03271893
180Asthma (HP:0002099)1.03250151
181Preaxial hand polydactyly (HP:0001177)1.02350658
182Male pseudohermaphroditism (HP:0000037)1.01987190
183Specific learning disability (HP:0001328)1.00365215
184Aplasia/Hypoplasia of the macula (HP:0008059)0.99770383
185Dysdiadochokinesis (HP:0002075)0.99365118
186Reticulocytopenia (HP:0001896)0.98641563
187Broad foot (HP:0001769)0.97968950
188Broad-based gait (HP:0002136)0.97007814
189Hypochromic microcytic anemia (HP:0004840)0.96819093
190Abnormality of the renal medulla (HP:0100957)0.95261749
191Anophthalmia (HP:0000528)0.94067458
192Visual hallucinations (HP:0002367)0.93685837
193Neoplasm of the adrenal cortex (HP:0100641)0.93438721
194Decreased testicular size (HP:0008734)0.92594272
195Abnormality of abdominal situs (HP:0011620)0.92045890
196Abdominal situs inversus (HP:0003363)0.92045890
197Furrowed tongue (HP:0000221)0.92013334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK15.67440090
2PBK5.45039204
3TLK15.03481238
4TRIB34.43674478
5SMG13.75677851
6MKNK23.53880772
7IRAK23.38957559
8VRK23.17626561
9STK163.05291118
10CASK2.98284873
11IRAK32.94118223
12BUB12.87332890
13PRKD32.44126915
14EEF2K2.37881655
15MAP3K102.35825087
16TAF12.21971073
17BRD41.89459993
18SIK21.86547113
19RPS6KB21.80410826
20MKNK11.76064216
21CSNK1G31.62245872
22MAP2K71.59677426
23PINK11.59064445
24PASK1.58253858
25TNIK1.52970307
26ICK1.52644655
27PKN21.52545380
28PDK21.51592570
29PRPF4B1.51142334
30HIPK21.47804453
31MAPK151.46136333
32GRK71.41011407
33SRPK11.39591194
34CDK81.37248740
35BRSK11.35891759
36CSNK1G11.33619550
37CDK71.30324431
38GRK51.30189825
39ILK1.28190993
40CSNK1A1L1.27034331
41DYRK1A1.25206200
42CDC71.22798301
43SIK11.20043579
44ERBB21.18941449
45INSRR1.14422126
46SGK2231.12879322
47SGK4941.12879322
48MAPK111.12036907
49CDK191.10920133
50ADRBK11.09615491
51PKN11.07946743
52BCKDK1.06496450
53CDK31.05606672
54ATR1.04355357
55MTOR1.03426523
56NME11.01886128
57TNK21.01828368
58PRKD21.00585493
59CDK90.98789845
60CSNK1G20.96419384
61MAPK130.95804789
62RPS6KA50.93263605
63NUAK10.92876915
64TTK0.90469027
65FES0.89883330
66ZAK0.89043314
67DAPK30.87459163
68TAOK30.86559638
69MAPKAPK30.83396797
70DYRK1B0.82978995
71PNCK0.82525662
72PRKG20.81836712
73BLK0.81646906
74MELK0.80737084
75MAP2K30.77121486
76DAPK10.76781365
77CDK40.76359588
78VRK10.73833787
79IKBKE0.73669605
80PLK10.73443101
81FGFR20.73137492
82TTN0.72937403
83AKT20.72640257
84YES10.72503692
85CHEK10.72396341
86STK390.71062370
87CAMK1D0.71037310
88PRKCI0.70791485
89AURKB0.70480304
90MARK10.66804158
91RPS6KC10.66539970
92RPS6KL10.66539970
93NTRK30.66415106
94NEK60.66407344
95WNK10.66265652
96STK40.66111467
97BRAF0.64605753
98RPS6KA20.64322474
99MUSK0.63528489
100MAPK120.62703912
101ABL20.62254859
102CDK120.61739931
103CAMK2D0.61630680
104RPS6KA60.59788574
105WNK40.58659942
106KDR0.55898657
107CSNK1D0.54138793
108CAMK2A0.53800669
109EIF2AK10.53562115
110PDPK10.53273576
111PHKG10.53011437
112PHKG20.53011437
113PIK3CA0.52372983
114CAMKK20.52171437
115CAMK2B0.51981015
116PLK40.51796247
117SGK20.51738465
118PRKAA10.50845791
119SGK10.50184461
120UHMK10.50125529
121ADRBK20.49946435
122IRAK10.48778726
123NME20.48554130
124CDK11A0.47524412
125CDK20.46748841
126BMPR1B0.46238982
127BRSK20.44486568
128PRKCB0.44372386
129NTRK20.44233059
130PTK20.43178331
131NEK20.41704708
132PRKCZ0.41408253
133MST1R0.41146327
134CSNK1E0.40877554
135EIF2AK20.40753484
136GSK3B0.40655768
137STK110.40566521
138DYRK20.40299861
139MAPK140.39738593
140PLK20.39494831
141PIM20.39304964
142MAPKAPK50.39202392
143IRAK40.38544506
144CDK10.38517003
145TXK0.38210984
146PRKG10.37826843
147CDK150.37810442
148MAP3K40.37525689
149MAPK70.36329737
150CDK50.36294024
151AURKA0.35267216
152ATM0.35056433
153CHEK20.34587252
154STK380.34566425
155CAMK1G0.34196088
156PRKACA0.33964750
157MAP2K60.32600909
158PLK30.32468681
159CAMKK10.31704689
160PRKDC0.31695896
161RPS6KA30.31458789
162CDK180.31372968
163AKT30.30725998
164CAMK10.30566382
165DYRK30.30456293
166MAPK90.30290154
167PRKACG0.29317533
168MAP2K20.29058508

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.26315008
2DNA replication_Homo sapiens_hsa030302.93512493
3Base excision repair_Homo sapiens_hsa034102.31142148
4Vitamin B6 metabolism_Homo sapiens_hsa007502.25398802
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21793475
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.17854542
7Phototransduction_Homo sapiens_hsa0474413.9142240
8Synaptic vesicle cycle_Homo sapiens_hsa047211.93336422
9Mismatch repair_Homo sapiens_hsa034301.88676836
10Sulfur metabolism_Homo sapiens_hsa009201.86960696
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85766199
12Pyrimidine metabolism_Homo sapiens_hsa002401.81441285
13Hedgehog signaling pathway_Homo sapiens_hsa043401.79535145
14One carbon pool by folate_Homo sapiens_hsa006701.67885672
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.67026172
16Basal cell carcinoma_Homo sapiens_hsa052171.62410610
17Olfactory transduction_Homo sapiens_hsa047401.57253706
18Fructose and mannose metabolism_Homo sapiens_hsa000511.57129619
19GABAergic synapse_Homo sapiens_hsa047271.51430694
20RNA transport_Homo sapiens_hsa030131.47091118
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40854158
22Nicotine addiction_Homo sapiens_hsa050331.38429953
23Cell cycle_Homo sapiens_hsa041101.35785001
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34919915
25Morphine addiction_Homo sapiens_hsa050321.30905834
26Serotonergic synapse_Homo sapiens_hsa047261.29220603
27mTOR signaling pathway_Homo sapiens_hsa041501.29143965
28Glutamatergic synapse_Homo sapiens_hsa047241.26611135
29Bladder cancer_Homo sapiens_hsa052191.25419627
30Cholinergic synapse_Homo sapiens_hsa047251.21460111
31Circadian entrainment_Homo sapiens_hsa047131.19320740
32Ribosome_Homo sapiens_hsa030101.19187656
33Selenocompound metabolism_Homo sapiens_hsa004501.18388652
34Alcoholism_Homo sapiens_hsa050341.13001585
35Systemic lupus erythematosus_Homo sapiens_hsa053221.04573964
36Hippo signaling pathway_Homo sapiens_hsa043901.03804864
37Dopaminergic synapse_Homo sapiens_hsa047281.00450935
38Folate biosynthesis_Homo sapiens_hsa007900.98153221
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97652641
40Lysine degradation_Homo sapiens_hsa003100.97643748
41N-Glycan biosynthesis_Homo sapiens_hsa005100.96479388
42Galactose metabolism_Homo sapiens_hsa000520.93482505
43Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91129139
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89507641
45p53 signaling pathway_Homo sapiens_hsa041150.88430090
46Oxidative phosphorylation_Homo sapiens_hsa001900.88235056
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88182214
48Biosynthesis of amino acids_Homo sapiens_hsa012300.85870649
49Notch signaling pathway_Homo sapiens_hsa043300.85812551
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.85475141
51Collecting duct acid secretion_Homo sapiens_hsa049660.85314552
52TGF-beta signaling pathway_Homo sapiens_hsa043500.81247299
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79139583
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76099911
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72943764
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72514710
57Insulin secretion_Homo sapiens_hsa049110.72138953
58Vibrio cholerae infection_Homo sapiens_hsa051100.71620639
59Non-homologous end-joining_Homo sapiens_hsa034500.71126409
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71049108
61Circadian rhythm_Homo sapiens_hsa047100.71016065
62Cardiac muscle contraction_Homo sapiens_hsa042600.70677742
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69421181
64Protein export_Homo sapiens_hsa030600.69171524
65Salivary secretion_Homo sapiens_hsa049700.68890346
66Non-small cell lung cancer_Homo sapiens_hsa052230.68708362
67Huntingtons disease_Homo sapiens_hsa050160.67762915
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67604559
69Fanconi anemia pathway_Homo sapiens_hsa034600.65476274
70AMPK signaling pathway_Homo sapiens_hsa041520.64714610
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.63233515
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63164333
73Alzheimers disease_Homo sapiens_hsa050100.62126431
74Purine metabolism_Homo sapiens_hsa002300.62118558
75Parkinsons disease_Homo sapiens_hsa050120.59156139
76RNA degradation_Homo sapiens_hsa030180.57444844
77ABC transporters_Homo sapiens_hsa020100.57100144
78Arginine and proline metabolism_Homo sapiens_hsa003300.56806714
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56776289
80Taste transduction_Homo sapiens_hsa047420.55135894
81Metabolic pathways_Homo sapiens_hsa011000.54290918
82Regulation of autophagy_Homo sapiens_hsa041400.53741283
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53683745
84Renin secretion_Homo sapiens_hsa049240.53275960
85Spliceosome_Homo sapiens_hsa030400.52738215
86mRNA surveillance pathway_Homo sapiens_hsa030150.51989217
87Glioma_Homo sapiens_hsa052140.51242997
88Type II diabetes mellitus_Homo sapiens_hsa049300.50325369
89Retinol metabolism_Homo sapiens_hsa008300.49591625
90Long-term depression_Homo sapiens_hsa047300.49493310
91Pentose phosphate pathway_Homo sapiens_hsa000300.49434775
92Cocaine addiction_Homo sapiens_hsa050300.48705187
93Vitamin digestion and absorption_Homo sapiens_hsa049770.47508394
94Small cell lung cancer_Homo sapiens_hsa052220.46935457
95Pyruvate metabolism_Homo sapiens_hsa006200.46636627
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46422266
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45969996
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.45921545
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45539800
100Thyroid cancer_Homo sapiens_hsa052160.45361921
101Long-term potentiation_Homo sapiens_hsa047200.45267204
102Basal transcription factors_Homo sapiens_hsa030220.44810954
103Chemokine signaling pathway_Homo sapiens_hsa040620.43789327
104Ether lipid metabolism_Homo sapiens_hsa005650.43469765
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43014688
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42644383
107Gastric acid secretion_Homo sapiens_hsa049710.41025816
108Oxytocin signaling pathway_Homo sapiens_hsa049210.41013955
109cAMP signaling pathway_Homo sapiens_hsa040240.40631834
110Glutathione metabolism_Homo sapiens_hsa004800.40216263
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.39388995
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39376278
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39268675
114RNA polymerase_Homo sapiens_hsa030200.38393873
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37024391
116Nucleotide excision repair_Homo sapiens_hsa034200.36788934
117Proteasome_Homo sapiens_hsa030500.36718990
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36624418
119Homologous recombination_Homo sapiens_hsa034400.36560259
120Sphingolipid metabolism_Homo sapiens_hsa006000.35326513
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35314877
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33659805
123Insulin signaling pathway_Homo sapiens_hsa049100.33410759
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33112908
125Calcium signaling pathway_Homo sapiens_hsa040200.32886945
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32217369
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32116885
128African trypanosomiasis_Homo sapiens_hsa051430.31364799
129Amphetamine addiction_Homo sapiens_hsa050310.30361139
130Pancreatic secretion_Homo sapiens_hsa049720.30139298
131Inositol phosphate metabolism_Homo sapiens_hsa005620.28764185
132Hematopoietic cell lineage_Homo sapiens_hsa046400.28419582
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28075928
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27725118
135Rheumatoid arthritis_Homo sapiens_hsa053230.27622317
136Axon guidance_Homo sapiens_hsa043600.26915128
137Fatty acid elongation_Homo sapiens_hsa000620.26763963
138Oocyte meiosis_Homo sapiens_hsa041140.26751202
139Chronic myeloid leukemia_Homo sapiens_hsa052200.26313499
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25896557
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25252955
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25019151
143Autoimmune thyroid disease_Homo sapiens_hsa053200.24663226
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24422573
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24405898
146Graft-versus-host disease_Homo sapiens_hsa053320.23864384
147Wnt signaling pathway_Homo sapiens_hsa043100.23373593
148Ras signaling pathway_Homo sapiens_hsa040140.22829472
149Vascular smooth muscle contraction_Homo sapiens_hsa042700.21539660
150Melanogenesis_Homo sapiens_hsa049160.21316822
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21167590
152GnRH signaling pathway_Homo sapiens_hsa049120.20886640
153Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20691236
154Mineral absorption_Homo sapiens_hsa049780.20314772
155Allograft rejection_Homo sapiens_hsa053300.19551722
156Intestinal immune network for IgA production_Homo sapiens_hsa046720.19516634
157Linoleic acid metabolism_Homo sapiens_hsa005910.19382095
158MAPK signaling pathway_Homo sapiens_hsa040100.18727280
159Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17068918
160Herpes simplex infection_Homo sapiens_hsa051680.16706731
161Gap junction_Homo sapiens_hsa045400.16423129
162Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15800703
163Choline metabolism in cancer_Homo sapiens_hsa052310.15576204
164Melanoma_Homo sapiens_hsa052180.15352131
165Asthma_Homo sapiens_hsa053100.15314868

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