SAMD10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.26765449
2negative regulation of microtubule polymerization (GO:0031115)6.23146454
3CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.67513130
4response to pheromone (GO:0019236)5.54019314
5nucleobase catabolic process (GO:0046113)5.40667157
6negative T cell selection (GO:0043383)4.47209267
7B cell receptor signaling pathway (GO:0050853)4.42315493
8negative thymic T cell selection (GO:0045060)4.37787537
9regulation of B cell receptor signaling pathway (GO:0050855)4.35181763
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.25517940
11thymic T cell selection (GO:0045061)4.21059925
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.18002720
13antigen processing and presentation of endogenous antigen (GO:0019883)4.12700849
14B cell homeostasis (GO:0001782)4.07288493
15response to interleukin-15 (GO:0070672)4.04873651
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.03076307
17positive regulation of B cell differentiation (GO:0045579)4.02809228
18cell migration in hindbrain (GO:0021535)3.93906877
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.93081589
20dendritic spine morphogenesis (GO:0060997)3.91759409
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.91601788
22neuron cell-cell adhesion (GO:0007158)3.86768039
23positive regulation of gamma-delta T cell activation (GO:0046645)3.85158182
24regulation of synapse structural plasticity (GO:0051823)3.83402629
25positive thymic T cell selection (GO:0045059)3.80138735
26spliceosomal tri-snRNP complex assembly (GO:0000244)3.77781347
27NIK/NF-kappaB signaling (GO:0038061)3.76553489
28response to muramyl dipeptide (GO:0032495)3.73728192
29T cell lineage commitment (GO:0002360)3.71218364
30layer formation in cerebral cortex (GO:0021819)3.71009117
31regulation of synaptic vesicle exocytosis (GO:2000300)3.67364903
32adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.65444652
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.60477111
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.57932198
35ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.55761229
36cellular response to prostaglandin stimulus (GO:0071379)3.54951002
37positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.52194723
38mucosal-associated lymphoid tissue development (GO:0048537)3.51898553
39Peyers patch development (GO:0048541)3.51898553
40neuron fate specification (GO:0048665)3.47792625
41synaptic vesicle exocytosis (GO:0016079)3.46326565
42neurofilament cytoskeleton organization (GO:0060052)3.44946256
43negative regulation of B cell apoptotic process (GO:0002903)3.44857403
44regulation of B cell differentiation (GO:0045577)3.43452510
45tolerance induction (GO:0002507)3.39708831
46modulation by virus of host process (GO:0019054)3.39591520
47central nervous system projection neuron axonogenesis (GO:0021952)3.38216436
48cerebellum development (GO:0021549)3.32578914
49synaptic vesicle maturation (GO:0016188)3.32439529
50neuron recognition (GO:0008038)3.27686641
51dopaminergic neuron differentiation (GO:0071542)3.27236705
52positive T cell selection (GO:0043368)3.26577950
53regulation of interferon-beta biosynthetic process (GO:0045357)3.24909893
54T cell selection (GO:0045058)3.24585117
55regulation of chromatin binding (GO:0035561)3.24336747
56positive regulation of interleukin-4 production (GO:0032753)3.22799433
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.22608352
58protein localization to synapse (GO:0035418)3.21987715
59regulation of autophagic vacuole assembly (GO:2000785)3.21674210
60magnesium ion transport (GO:0015693)3.21267035
61Arp2/3 complex-mediated actin nucleation (GO:0034314)3.20628097
62COPI coating of Golgi vesicle (GO:0048205)3.19797739
63Golgi transport vesicle coating (GO:0048200)3.19797739
64regulation of synaptic vesicle transport (GO:1902803)3.18217499
65negative regulation of cell killing (GO:0031342)3.17870159
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.17870159
67regulation of short-term neuronal synaptic plasticity (GO:0048172)3.17506212
68negative regulation of DNA-templated transcription, elongation (GO:0032785)3.17134287
69melanosome transport (GO:0032402)3.16156570
70establishment of melanosome localization (GO:0032401)3.16108667
71T cell migration (GO:0072678)3.15326684
72negative regulation of bone resorption (GO:0045779)3.14365480
73positive regulation of gastrulation (GO:2000543)3.14172215
74response to type I interferon (GO:0034340)3.13618300
75activation of MAPKKK activity (GO:0000185)3.11061331
76axonal fasciculation (GO:0007413)3.10949849
77type I interferon signaling pathway (GO:0060337)3.07348882
78cellular response to type I interferon (GO:0071357)3.07348882
79tumor necrosis factor-mediated signaling pathway (GO:0033209)3.07260081
80regulation of interleukin-4 production (GO:0032673)3.06402384
81peptidyl-arginine N-methylation (GO:0035246)3.05743102
82peptidyl-arginine methylation (GO:0018216)3.05743102
83membrane budding (GO:0006900)3.05466205
84endocrine pancreas development (GO:0031018)3.03999409
85regulation of vesicle fusion (GO:0031338)3.02935503
86cellular response to interferon-beta (GO:0035458)3.02671578
87vocalization behavior (GO:0071625)3.01613616
88stress granule assembly (GO:0034063)3.01314262
89histone H3-K4 trimethylation (GO:0080182)3.01252113
90regulation of microtubule polymerization (GO:0031113)3.00464316
91regulation of interleukin-2 biosynthetic process (GO:0045076)3.00387460
92peptidyl-arginine omega-N-methylation (GO:0035247)2.99132674
93positive regulation of histone deacetylation (GO:0031065)2.98708822
94establishment of pigment granule localization (GO:0051905)2.97545032
95pigment granule transport (GO:0051904)2.96706671
96regulation of hydrogen peroxide metabolic process (GO:0010310)2.95769526
97retinal ganglion cell axon guidance (GO:0031290)2.94892236
98regulation of glutamate receptor signaling pathway (GO:1900449)2.94706208
99dendrite morphogenesis (GO:0048813)2.94518950
100antigen receptor-mediated signaling pathway (GO:0050851)2.93999556
101T cell costimulation (GO:0031295)2.91939707
102behavioral response to nicotine (GO:0035095)2.91154557
103modulation by symbiont of host cellular process (GO:0044068)2.91110477
104melanosome localization (GO:0032400)2.90918257
105signal complex assembly (GO:0007172)2.90407176
106positive regulation by organism of defense response of other organism involved in symbiotic interact2.90089442
107modulation by symbiont of host immune response (GO:0052553)2.90089442
108positive regulation by symbiont of host defense response (GO:0052509)2.90089442
109modulation by symbiont of host defense response (GO:0052031)2.90089442
110modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.90089442
111modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90089442
112endosome to melanosome transport (GO:0035646)2.89555108
113endosome to pigment granule transport (GO:0043485)2.89555108
114myeloid dendritic cell activation (GO:0001773)2.88418362
115lymphocyte costimulation (GO:0031294)2.86645898
116positive regulation of interleukin-2 production (GO:0032743)2.86317656
117positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.86001669
118lymphocyte homeostasis (GO:0002260)2.85498668
119positive regulation of granulocyte differentiation (GO:0030854)2.84436425
120myeloid dendritic cell differentiation (GO:0043011)2.84274202
121regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.83823309
122positive regulation of synapse assembly (GO:0051965)2.83129981
123regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.82283451
124regulation of protein heterodimerization activity (GO:0043497)2.82245526
125regulation of gamma-delta T cell activation (GO:0046643)2.80891494
126cytidine deamination (GO:0009972)2.80468671
127cytidine metabolic process (GO:0046087)2.80468671
128cytidine catabolic process (GO:0006216)2.80468671
129axon cargo transport (GO:0008088)2.79535871
130regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.78469812
131detection of bacterium (GO:0016045)2.78257740
132regulation of respiratory system process (GO:0044065)2.77700396
133regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.77686482
134dendritic spine organization (GO:0097061)2.77550397
135interferon-gamma-mediated signaling pathway (GO:0060333)2.76378657
136negative regulation of phagocytosis (GO:0050765)2.75843931
137pigment granule localization (GO:0051875)2.74951192
138regulation of defense response to virus by virus (GO:0050690)2.74002039
139positive regulation of synaptic transmission, GABAergic (GO:0032230)2.73086559
140neurotransmitter secretion (GO:0007269)2.72997536
141regulation of vacuole organization (GO:0044088)2.72389799
142innervation (GO:0060384)2.71993666
143positive regulation of insulin secretion (GO:0032024)2.71620281
144urinary tract smooth muscle contraction (GO:0014848)2.71497817
145cellular response to virus (GO:0098586)2.70907879
146response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70570832
147response to host immune response (GO:0052572)2.70570832
148regulation of cAMP-dependent protein kinase activity (GO:2000479)2.70067194
149N-glycan processing (GO:0006491)2.70054486
150negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69865188
151interferon-gamma secretion (GO:0072643)2.69376785
152cellular response to interleukin-4 (GO:0071353)2.69347154
153cellular response to glucagon stimulus (GO:0071377)2.68969000
154interferon-gamma production (GO:0032609)2.68761952
155negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.67566023
156positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.67018997
157positive regulation of filopodium assembly (GO:0051491)2.66905918
158regulation of interferon-gamma biosynthetic process (GO:0045072)2.66293806
159intracellular estrogen receptor signaling pathway (GO:0030520)2.65463441
160immunoglobulin mediated immune response (GO:0016064)2.64945436
161postsynaptic membrane organization (GO:0001941)2.64927770
162protein insertion into membrane (GO:0051205)2.64824799
163purine nucleoside diphosphate metabolic process (GO:0009135)2.64290043
164purine ribonucleoside diphosphate metabolic process (GO:0009179)2.64290043
165viral protein processing (GO:0019082)2.64110351
166negative regulation of myeloid cell apoptotic process (GO:0033033)2.64048336
167regulation of calcium ion-dependent exocytosis (GO:0017158)2.61766542
168positive regulation of B cell proliferation (GO:0030890)2.61550993
169neuronal action potential propagation (GO:0019227)2.61373868
170establishment of synaptic vesicle localization (GO:0097480)2.61076378
171synaptic vesicle transport (GO:0048489)2.61076378
172leukocyte homeostasis (GO:0001776)2.61011615
173metallo-sulfur cluster assembly (GO:0031163)2.60997255
174iron-sulfur cluster assembly (GO:0016226)2.60997255
175dendrite development (GO:0016358)2.60929178
176dopamine receptor signaling pathway (GO:0007212)2.60894642
177regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.58232261
178response to auditory stimulus (GO:0010996)2.58165577
179glutamate secretion (GO:0014047)2.57988520
180response to misfolded protein (GO:0051788)2.57819595
181regulation of type B pancreatic cell apoptotic process (GO:2000674)2.56954337
182anterograde axon cargo transport (GO:0008089)2.56703672
183cranial nerve morphogenesis (GO:0021602)2.56676324
184regulation of axon extension (GO:0030516)2.55513583
185de novo posttranslational protein folding (GO:0051084)2.53593571
186regulation of respiratory gaseous exchange (GO:0043576)2.53591052
187synaptic vesicle docking involved in exocytosis (GO:0016081)2.53081692
188anterograde synaptic vesicle transport (GO:0048490)2.53078680
189histone arginine methylation (GO:0034969)2.52372894
190cellular response to interleukin-15 (GO:0071350)2.52310523
191regulation of synapse assembly (GO:0051963)2.51826810
192auditory behavior (GO:0031223)2.51650886
193exploration behavior (GO:0035640)2.51255415
194establishment of vesicle localization (GO:0051650)2.51120582
195neuromuscular synaptic transmission (GO:0007274)2.50758617
196cerebellar Purkinje cell differentiation (GO:0021702)2.50350950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.35419319
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.09705141
3MYC_22102868_ChIP-Seq_BL_Human4.04919432
4VDR_21846776_ChIP-Seq_THP-1_Human3.51377058
5REST_21632747_ChIP-Seq_MESCs_Mouse2.75464270
6LXR_22292898_ChIP-Seq_THP-1_Human2.63136318
7ZNF274_21170338_ChIP-Seq_K562_Hela2.62709389
8DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.61195729
9REST_18959480_ChIP-ChIP_MESCs_Mouse2.55369994
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.52763114
11* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.49811439
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.48498556
13IGF1R_20145208_ChIP-Seq_DFB_Human2.48089943
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44818077
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42021905
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.39106966
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.37988294
18* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.19092883
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.17951607
20* MAF_26560356_Chip-Seq_TH1_Human2.17153474
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14018869
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11199083
23JARID2_20064375_ChIP-Seq_MESCs_Mouse2.09000083
24OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.08692286
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06052313
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05916919
27MAF_26560356_Chip-Seq_TH2_Human2.05578298
28UTX_26944678_Chip-Seq_JUKART_Human2.02677634
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01741101
30KDM2B_26808549_Chip-Seq_DND41_Human2.01645853
31* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95935586
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.91887805
33P68_20966046_ChIP-Seq_HELA_Human1.91153236
34RNF2_27304074_Chip-Seq_NSC_Mouse1.88193003
35TCF7_22412390_ChIP-Seq_EML_Mouse1.87823498
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86254877
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82602046
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82185454
39BCL6_27268052_Chip-Seq_Bcells_Human1.80279405
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78434422
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.76856626
42GBX2_23144817_ChIP-Seq_PC3_Human1.75535284
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75502071
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74328081
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.74042340
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.73750593
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72169984
48VDR_24763502_ChIP-Seq_THP-1_Human1.71411510
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.70823774
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70090330
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70090330
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67586719
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.66397768
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66356074
55* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.65816836
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65526001
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.65041357
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64120730
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63785199
60ZNF263_19887448_ChIP-Seq_K562_Human1.63442920
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63036395
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62668309
63BCOR_27268052_Chip-Seq_Bcells_Human1.61513006
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61424576
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.60568139
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60422230
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59536516
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.59413586
69* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58585683
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58531875
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56649941
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55908567
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52267057
74* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49853740
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.48128043
76* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47551482
77XRN2_22483619_ChIP-Seq_HELA_Human1.46760562
78* RACK7_27058665_Chip-Seq_MCF-7_Human1.44567102
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.43311530
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39972597
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39920349
82* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39896423
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39200092
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38486433
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38459023
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38154876
87DROSHA_22980978_ChIP-Seq_HELA_Human1.37599793
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37351300
89* MYB_26560356_Chip-Seq_TH1_Human1.36403424
90GABP_19822575_ChIP-Seq_HepG2_Human1.36382301
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.34606491
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33344177
93CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.32971225
94STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32538118
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.32408505
96PHF8_20622854_ChIP-Seq_HELA_Human1.31828443
97CTCF_26484167_Chip-Seq_Bcells_Mouse1.31772630
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.31154082
99SMC4_20622854_ChIP-Seq_HELA_Human1.30421153
100ETS1_20019798_ChIP-Seq_JURKAT_Human1.29737074
101* MYB_26560356_Chip-Seq_TH2_Human1.27991311
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26996585
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25615625
104TP63_17297297_ChIP-ChIP_HaCaT_Human1.25514955
105NCOR1_26117541_ChIP-Seq_K562_Human1.24867744
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24549126
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22110340
108RARB_24833708_ChIP-Seq_LIVER_Mouse1.21433014
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21290739
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.20889874
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20644672
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.20610775
113TAF15_26573619_Chip-Seq_HEK293_Human1.20300998
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19791140
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19692239
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19180268
117KDM5A_27292631_Chip-Seq_BREAST_Human1.18709920
118E2F1_20622854_ChIP-Seq_HELA_Human1.18536300
119SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.17382932
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16136381
121* FOXP1_21924763_ChIP-Seq_HESCs_Human1.15239996
122* SPI1_23547873_ChIP-Seq_NB4_Human1.15031595
123EED_16625203_ChIP-ChIP_MESCs_Mouse1.14489757
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13786602
125RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13244172
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13003113
127CTCF_21964334_ChIP-Seq_BJAB-B_Human1.12673388
128SCL_19346495_ChIP-Seq_HPC-7_Human1.12044890
129MYC_18555785_ChIP-Seq_MESCs_Mouse1.10705334
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10057144
131CREB1_26743006_Chip-Seq_LNCaP_Human1.10042657
132GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09335665
133ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09070085
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08836597
135CTCF_21964334_Chip-Seq_Bcells_Human1.08662213
136SA1_27219007_Chip-Seq_Bcells_Human1.08354680
137THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08238264
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08092781
139ETS1_21867929_ChIP-Seq_TH2_Mouse1.07785065
140ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07057412
141ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06158749
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05360545
143FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02620789
144* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.02467625
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02389657
146RING1B_27294783_Chip-Seq_NPCs_Mouse1.01342606
147CIITA_25753668_ChIP-Seq_RAJI_Human1.00298413
148ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00113510
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98900492
150* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97944653
151CTCF_27219007_Chip-Seq_Bcells_Human0.96799362
152CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96582592
153AR_25329375_ChIP-Seq_VCAP_Human0.96073365
154CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94148704
155VDR_22108803_ChIP-Seq_LS180_Human0.93605592
156POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90773667
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90773667
158* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90429043
159CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89934072
160* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89850935
161ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89072425
162RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88995629
163SOX3_22085726_ChIP-Seq_NPCs_Mouse0.88547860
164SOX2_21211035_ChIP-Seq_LN229_Gbm0.87324895
165P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86968690
166* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84761364
167GABP_17652178_ChIP-ChIP_JURKAT_Human0.84152186
168PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82698272
169TET1_21490601_ChIP-Seq_MESCs_Mouse0.82587637
170POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.81256345
171CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80132733
172GATA1_26923725_Chip-Seq_HPCs_Mouse0.79949647
173SMAD3_21741376_ChIP-Seq_ESCs_Human0.79908621
174TET1_21451524_ChIP-Seq_MESCs_Mouse0.78314076
175YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78278255
176P300_19829295_ChIP-Seq_ESCs_Human0.77532399
177THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76122193
178KDM2B_26808549_Chip-Seq_K562_Human0.76074137
179CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.75557800
180GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72866121
181PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72493890
182WDR5_24793694_ChIP-Seq_LNCAP_Human0.72274853

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006276_abnormal_autonomic_nervous3.88899539
2MP0005671_abnormal_response_to3.75522314
3MP0000685_abnormal_immune_system3.32969663
4MP0004859_abnormal_synaptic_plasticity3.31543227
5MP0001800_abnormal_humoral_immune3.20954293
6MP0003880_abnormal_central_pattern3.09605117
7MP0001873_stomach_inflammation3.04884887
8MP0001790_abnormal_immune_system3.04026069
9MP0005387_immune_system_phenotype3.04026069
10MP0001835_abnormal_antigen_presentation3.01931217
11MP0004270_analgesia2.98069493
12MP0005423_abnormal_somatic_nervous2.93335565
13MP0003183_abnormal_peptide_metabolism2.92763758
14MP0003763_abnormal_thymus_physiology2.87755656
15MP0003122_maternal_imprinting2.78956023
16MP0003436_decreased_susceptibility_to2.72560261
17MP0005000_abnormal_immune_tolerance2.71768965
18MP0002909_abnormal_adrenal_gland2.67806727
19MP0010386_abnormal_urinary_bladder2.55055294
20MP0002723_abnormal_immune_serum2.45842680
21MP0003635_abnormal_synaptic_transmissio2.45427239
22MP0005645_abnormal_hypothalamus_physiol2.43648347
23MP0002184_abnormal_innervation2.42720071
24MP0002420_abnormal_adaptive_immunity2.41160671
25MP0000778_abnormal_nervous_system2.38186923
26MP0001819_abnormal_immune_cell2.37864088
27MP0002398_abnormal_bone_marrow2.36367070
28MP0002734_abnormal_mechanical_nocicepti2.35128614
29MP0009333_abnormal_splenocyte_physiolog2.32932309
30MP0002733_abnormal_thermal_nociception2.31295608
31MP0002063_abnormal_learning/memory/cond2.29247570
32MP0002452_abnormal_antigen_presenting2.29066452
33MP0000716_abnormal_immune_system2.15252900
34MP0001984_abnormal_olfaction2.13632383
35MP0005025_abnormal_response_to2.13466995
36MP0001968_abnormal_touch/_nociception2.12060342
37MP0000703_abnormal_thymus_morphology1.97062140
38MP0002638_abnormal_pupillary_reflex1.95252071
39MP0000631_abnormal_neuroendocrine_gland1.94371093
40MP0002735_abnormal_chemical_nociception1.92730983
41MP0006072_abnormal_retinal_apoptosis1.92684224
42MP0005499_abnormal_olfactory_system1.87872885
43MP0005394_taste/olfaction_phenotype1.87872885
44MP0002751_abnormal_autonomic_nervous1.85665238
45MP0000569_abnormal_digit_pigmentation1.85500699
46MP0002722_abnormal_immune_system1.85103693
47MP0002429_abnormal_blood_cell1.84478510
48MP0005310_abnormal_salivary_gland1.81624040
49MP0001970_abnormal_pain_threshold1.79466283
50MP0001529_abnormal_vocalization1.78272170
51MP0008961_abnormal_basal_metabolism1.76300615
52MP0000689_abnormal_spleen_morphology1.75697334
53MP0002572_abnormal_emotion/affect_behav1.74705921
54MP0000678_abnormal_parathyroid_gland1.74239559
55MP0002557_abnormal_social/conspecific_i1.71994436
56MP0002736_abnormal_nociception_after1.71497183
57MP0000538_abnormal_urinary_bladder1.66813281
58MP0002822_catalepsy1.65737307
59MP0002693_abnormal_pancreas_physiology1.64967551
60MP0008789_abnormal_olfactory_epithelium1.64527363
61MP0000013_abnormal_adipose_tissue1.62242257
62MP0008260_abnormal_autophagy1.61867340
63MP0004811_abnormal_neuron_physiology1.61541797
64MP0003121_genomic_imprinting1.60319479
65MP0003866_abnormal_defecation1.58523513
66MP0001944_abnormal_pancreas_morphology1.56849119
67MP0002166_altered_tumor_susceptibility1.56778013
68MP0004947_skin_inflammation1.55452200
69MP0003890_abnormal_embryonic-extraembry1.52464154
70MP0000465_gastrointestinal_hemorrhage1.46036816
71MP0005451_abnormal_body_composition1.44736823
72MP0000955_abnormal_spinal_cord1.44613925
73MP0002067_abnormal_sensory_capabilities1.43855178
74MP0002396_abnormal_hematopoietic_system1.42779694
75MP0001502_abnormal_circadian_rhythm1.42254516
76MP0002653_abnormal_ependyma_morphology1.40587729
77MP0004381_abnormal_hair_follicle1.39988693
78MP0002064_seizures1.39018786
79MP0005075_abnormal_melanosome_morpholog1.38720001
80MP0002419_abnormal_innate_immunity1.38377769
81MP0005220_abnormal_exocrine_pancreas1.37315698
82MP0002405_respiratory_system_inflammati1.36640274
83MP0000003_abnormal_adipose_tissue1.36291872
84MP0010155_abnormal_intestine_physiology1.35023543
85MP0006292_abnormal_olfactory_placode1.34873710
86MP0009745_abnormal_behavioral_response1.34484758
87MP0009278_abnormal_bone_marrow1.33542002
88MP0002272_abnormal_nervous_system1.31732382
89MP0003787_abnormal_imprinting1.30740760
90MP0002102_abnormal_ear_morphology1.29211476
91MP0001986_abnormal_taste_sensitivity1.28595897
92MP0002138_abnormal_hepatobiliary_system1.24436431
93MP0001845_abnormal_inflammatory_respons1.24259116
94MP0006035_abnormal_mitochondrial_morpho1.24071322
95MP0005464_abnormal_platelet_physiology1.23211328
96MP0002882_abnormal_neuron_morphology1.22629064
97MP0002006_tumorigenesis1.21854122
98MP0002234_abnormal_pharynx_morphology1.20904333
99MP0002933_joint_inflammation1.19851662
100MP0003283_abnormal_digestive_organ1.18213761
101MP0003315_abnormal_perineum_morphology1.17908187
102MP0009046_muscle_twitch1.16959839
103MP0004133_heterotaxia1.16913896
104MP0000372_irregular_coat_pigmentation1.14012186
105MP0002019_abnormal_tumor_incidence1.13278672
106MP0005076_abnormal_cell_differentiation1.13205859
107MP0002152_abnormal_brain_morphology1.12844107
108MP0005386_behavior/neurological_phenoty1.11824428
109MP0004924_abnormal_behavior1.11824428
110MP0003303_peritoneal_inflammation1.11001792
111MP0003861_abnormal_nervous_system1.09459861
112MP0009785_altered_susceptibility_to1.09060482
113MP0005646_abnormal_pituitary_gland1.08032258
114MP0008872_abnormal_physiological_respon1.04618820
115MP0002148_abnormal_hypersensitivity_rea1.04229638
116MP0004858_abnormal_nervous_system1.04031984
117MP0001440_abnormal_grooming_behavior1.02968669
118MP0005379_endocrine/exocrine_gland_phen1.01686642
119MP0001905_abnormal_dopamine_level0.99683618
120MP0002249_abnormal_larynx_morphology0.99200104
121MP0008569_lethality_at_weaning0.98380505
122MP0000490_abnormal_crypts_of0.98350115
123MP0003942_abnormal_urinary_system0.98349778
124MP0003879_abnormal_hair_cell0.97650367
125MP0001486_abnormal_startle_reflex0.96929184
126MP0002163_abnormal_gland_morphology0.95146910
127MP0002066_abnormal_motor_capabilities/c0.94701372
128MP0001664_abnormal_digestion0.94497840
129MP0000537_abnormal_urethra_morphology0.93211466
130MP0010030_abnormal_orbit_morphology0.91622255
131MP0003119_abnormal_digestive_system0.91057557
132MP0000462_abnormal_digestive_system0.90565111
133MP0000534_abnormal_ureter_morphology0.89956704
134MP0001348_abnormal_lacrimal_gland0.88546768
135MP0002837_dystrophic_cardiac_calcinosis0.88262573
136MP0003172_abnormal_lysosome_physiology0.88261945
137MP0002177_abnormal_outer_ear0.88219263
138MP0008995_early_reproductive_senescence0.86808523
139MP0003693_abnormal_embryo_hatching0.85876640
140MP0002752_abnormal_somatic_nervous0.85777383
141MP0002089_abnormal_postnatal_growth/wei0.81663378
142MP0000015_abnormal_ear_pigmentation0.81500650
143MP0005397_hematopoietic_system_phenotyp0.80764038
144MP0001545_abnormal_hematopoietic_system0.80764038
145MP0005187_abnormal_penis_morphology0.77997164
146MP0000681_abnormal_thyroid_gland0.77674327
147MP0008874_decreased_physiological_sensi0.77332607
148MP0000313_abnormal_cell_death0.76434132
149MP0004885_abnormal_endolymph0.75890116
150MP0004742_abnormal_vestibular_system0.75127806
151MP0004264_abnormal_extraembryonic_tissu0.74521081
152MP0000049_abnormal_middle_ear0.73743956
153MP0002069_abnormal_eating/drinking_beha0.73614422
154MP0005375_adipose_tissue_phenotype0.73352122
155MP0002277_abnormal_respiratory_mucosa0.72599276
156MP0003191_abnormal_cellular_cholesterol0.72244241
157MP0000858_altered_metastatic_potential0.71769929
158MP0003329_amyloid_beta_deposits0.71703957
159MP0008469_abnormal_protein_level0.71209906
160MP0003953_abnormal_hormone_level0.70909277
161MP0002132_abnormal_respiratory_system0.70616673
162MP0001270_distended_abdomen0.67029074
163MP0001501_abnormal_sleep_pattern0.66527617
164MP0002938_white_spotting0.66475312
165MP0004808_abnormal_hematopoietic_stem0.66249660
166MP0000026_abnormal_inner_ear0.66124907
167MP0004142_abnormal_muscle_tone0.65468765
168MP0003868_abnormal_feces_composition0.64711846
169MP0010094_abnormal_chromosome_stability0.62073990
170MP0003111_abnormal_nucleus_morphology0.61344514
171MP0001663_abnormal_digestive_system0.61175386
172MP0003724_increased_susceptibility_to0.60880117
173MP0001853_heart_inflammation0.59484684
174MP0000609_abnormal_liver_physiology0.57944982

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.51893092
2Panhypogammaglobulinemia (HP:0003139)5.35183637
3Gastrointestinal stroma tumor (HP:0100723)4.51839298
4Abnormal delayed hypersensitivity skin test (HP:0002963)4.34355773
5Meningitis (HP:0001287)4.22617382
6Recurrent sinusitis (HP:0011108)4.02537023
7Failure to thrive in infancy (HP:0001531)3.96814181
8IgA deficiency (HP:0002720)3.83842373
9Hypothermia (HP:0002045)3.74262664
10Limb dystonia (HP:0002451)3.72692393
11Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.68811216
12Recurrent viral infections (HP:0004429)3.65378124
13Abnormality of T cell physiology (HP:0011840)3.64544786
14Colitis (HP:0002583)3.57815798
15Cellulitis (HP:0100658)3.54117715
16IgM deficiency (HP:0002850)3.41191591
17Aplasia/Hypoplasia of the brainstem (HP:0007362)3.41154809
18Hypoplasia of the brainstem (HP:0002365)3.41154809
19Myokymia (HP:0002411)3.40481174
20Agitation (HP:0000713)3.40263157
21Increased IgE level (HP:0003212)3.40058551
22Lissencephaly (HP:0001339)3.37118288
23Polyphagia (HP:0002591)3.35489760
24Lymphopenia (HP:0001888)3.31936691
25IgG deficiency (HP:0004315)3.29652648
26Recurrent fungal infections (HP:0002841)3.26493602
27Recurrent bronchitis (HP:0002837)3.22886914
28Recurrent cutaneous fungal infections (HP:0011370)3.22234936
29Chronic mucocutaneous candidiasis (HP:0002728)3.22234936
30Hypertensive crisis (HP:0100735)3.21756233
31Mediastinal lymphadenopathy (HP:0100721)3.18449931
32Exotropia (HP:0000577)3.17723467
33Abnormality of cells of the lymphoid lineage (HP:0012140)3.10278710
34Amyotrophic lateral sclerosis (HP:0007354)3.09125320
35Gastrointestinal inflammation (HP:0004386)3.08989559
36Increased IgM level (HP:0003496)3.08268837
37Neuroendocrine neoplasm (HP:0100634)3.00982183
38Pheochromocytoma (HP:0002666)2.94903220
39Encephalitis (HP:0002383)2.94837529
40Vasculitis (HP:0002633)2.94633932
41Poor suck (HP:0002033)2.93757989
42Abnormality of small intestinal villus morphology (HP:0011472)2.91123976
43Villous atrophy (HP:0011473)2.91123976
44Verrucae (HP:0200043)2.87977584
45Papilloma (HP:0012740)2.87977584
46Viral hepatitis (HP:0006562)2.79438183
47Ankle clonus (HP:0011448)2.76846670
48Inflammation of the large intestine (HP:0002037)2.76287742
49Supranuclear gaze palsy (HP:0000605)2.76130625
50Atrophy/Degeneration involving motor neurons (HP:0007373)2.75082542
51Visual hallucinations (HP:0002367)2.74912728
52Recurrent lower respiratory tract infections (HP:0002783)2.71456524
53Seborrheic dermatitis (HP:0001051)2.71212098
54Pustule (HP:0200039)2.69987623
55Granulocytopenia (HP:0001913)2.68898003
56Abnormality of calcium-phosphate metabolism (HP:0100530)2.65545969
57Obstructive lung disease (HP:0006536)2.62994461
58Chronic obstructive pulmonary disease (HP:0006510)2.62994461
59Large eyes (HP:0001090)2.59574274
60Abnormality of T cells (HP:0002843)2.57748597
61Squamous cell carcinoma (HP:0002860)2.57167289
62Severe combined immunodeficiency (HP:0004430)2.55004393
63B lymphocytopenia (HP:0010976)2.48747489
64Eczematoid dermatitis (HP:0000976)2.46013728
65Progressive inability to walk (HP:0002505)2.45305519
66Gait imbalance (HP:0002141)2.44894322
67Emphysema (HP:0002097)2.44327166
68Hepatitis (HP:0012115)2.42294898
69Hypergammaglobulinemia (HP:0010702)2.41740145
70Abnormal number of erythroid precursors (HP:0012131)2.41525228
71Pulmonary infiltrates (HP:0002113)2.40547627
72Progressive cerebellar ataxia (HP:0002073)2.40472765
73Retinal dysplasia (HP:0007973)2.40061529
74Amblyopia (HP:0000646)2.38717021
75Poikiloderma (HP:0001029)2.38011783
76Basal cell carcinoma (HP:0002671)2.37612864
77Esotropia (HP:0000565)2.36735010
78Shoulder girdle muscle weakness (HP:0003547)2.33729964
79Sepsis (HP:0100806)2.33566000
80Abnormality of B cell number (HP:0010975)2.32530088
81Abnormality of cells of the erythroid lineage (HP:0012130)2.31688198
82Restrictive lung disease (HP:0002091)2.29041431
83Abnormality of the lower motor neuron (HP:0002366)2.28664948
84Nasal speech (HP:0001611)2.28404216
85Morphological abnormality of the middle ear (HP:0008609)2.28293636
86Epileptic encephalopathy (HP:0200134)2.25503741
87Abnormality of the prostate (HP:0008775)2.25107033
88Retrobulbar optic neuritis (HP:0100654)2.24791038
89Optic neuritis (HP:0100653)2.24791038
90Poor eye contact (HP:0000817)2.24579376
91Abnormal hair whorl (HP:0010721)2.24504145
92EEG with generalized epileptiform discharges (HP:0011198)2.23623709
93Growth hormone excess (HP:0000845)2.22995645
94Hypsarrhythmia (HP:0002521)2.21664668
95Recurrent pneumonia (HP:0006532)2.21337933
96Mutism (HP:0002300)2.20797714
97Recurrent skin infections (HP:0001581)2.18197817
98Abnormality of the anterior horn cell (HP:0006802)2.16649184
99Degeneration of anterior horn cells (HP:0002398)2.16649184
100Broad distal phalanx of finger (HP:0009836)2.15677508
101Menstrual irregularities (HP:0000858)2.15426906
102Deep palmar crease (HP:0006191)2.14592473
103Specific learning disability (HP:0001328)2.13332002
104Epileptiform EEG discharges (HP:0011182)2.12045638
105Abnormality of the parathyroid morphology (HP:0011766)2.11480914
106Cortical visual impairment (HP:0100704)2.11013936
107Progressive sensorineural hearing impairment (HP:0000408)2.09850681
108Hypoventilation (HP:0002791)2.09384473
109Thyroid-stimulating hormone excess (HP:0002925)2.08349140
110Neoplasm of the heart (HP:0100544)2.07225176
111Anterior segment dysgenesis (HP:0007700)2.07156714
112Hypercortisolism (HP:0001578)2.04309465
113Hyperacusis (HP:0010780)2.04160726
114Recurrent otitis media (HP:0000403)2.03688780
115Abnormal eating behavior (HP:0100738)2.03369032
116Drooling (HP:0002307)2.03223337
117Excessive salivation (HP:0003781)2.03223337
118Labial hypoplasia (HP:0000066)2.02287513
119Neoplasm of the adrenal gland (HP:0100631)2.01932866
120Spastic tetraplegia (HP:0002510)2.01815457
121Conical tooth (HP:0000698)2.01719472
122Clonus (HP:0002169)2.01468604
123Inability to walk (HP:0002540)2.01222831
124Urinary urgency (HP:0000012)1.99933662
125Papillary thyroid carcinoma (HP:0002895)1.98974317
126Aplasia/Hypoplasia of the thymus (HP:0010515)1.98931602
127Abnormal pancreas size (HP:0012094)1.98419393
128Myositis (HP:0100614)1.98329187
129Chronic bronchitis (HP:0004469)1.97551210
130Focal seizures (HP:0007359)1.97042620
131Sleep apnea (HP:0010535)1.96861449
132High anterior hairline (HP:0009890)1.96619615
133Severe visual impairment (HP:0001141)1.96468729
134Polymicrogyria (HP:0002126)1.96448486
135Macroorchidism (HP:0000053)1.96161328
136Ureteral stenosis (HP:0000071)1.95149715
137Skin rash (HP:0000988)1.95109447
138Spinal canal stenosis (HP:0003416)1.94549151
139Broad-based gait (HP:0002136)1.94418114
140Osteomyelitis (HP:0002754)1.94354955
141Long toe (HP:0010511)1.93578529
142Abnormality of male internal genitalia (HP:0000022)1.93492464
143Autoimmune hemolytic anemia (HP:0001890)1.93242771
144Febrile seizures (HP:0002373)1.93113452
145Abnormality of the vocal cords (HP:0008777)1.93103149
146Medial flaring of the eyebrow (HP:0010747)1.92104572
147Chronic diarrhea (HP:0002028)1.92081560
148Tinnitus (HP:0000360)1.89373454
149Short philtrum (HP:0000322)1.89193018
150Optic nerve coloboma (HP:0000588)1.88769940
151Long palpebral fissure (HP:0000637)1.88190290
152Megalocornea (HP:0000485)1.87193753
153Flattened epiphyses (HP:0003071)1.86784083
154Elfin facies (HP:0004428)1.85602302
155Symptomatic seizures (HP:0011145)1.85298439
156Nephrogenic diabetes insipidus (HP:0009806)1.85066362
157Orthostatic hypotension (HP:0001278)1.84496272
158Hemorrhage of the eye (HP:0011885)1.84395419
159Impaired smooth pursuit (HP:0007772)1.83980541
160Entropion (HP:0000621)1.83230162
161Chronic otitis media (HP:0000389)1.83221542
162Type II lissencephaly (HP:0007260)1.83136945
163Microvesicular hepatic steatosis (HP:0001414)1.82687685
164Leukopenia (HP:0001882)1.82502432
165Orchitis (HP:0100796)1.82132364
166Hypoplasia of the pons (HP:0012110)1.81595029
167Oligomenorrhea (HP:0000876)1.80880713
168Pachygyria (HP:0001302)1.80819131
169Lymphoma (HP:0002665)1.80805198
170Abnormality of lateral ventricle (HP:0030047)1.79944921
171Cholecystitis (HP:0001082)1.79873668
172Abnormal gallbladder physiology (HP:0012438)1.79873668
173Lip pit (HP:0100267)1.79366852
174Atonic seizures (HP:0010819)1.79158872
175Combined immunodeficiency (HP:0005387)1.76746939
176Ureteral obstruction (HP:0006000)1.76463982
177Papilledema (HP:0001085)1.76456307
178Rimmed vacuoles (HP:0003805)1.75617698
179Anxiety (HP:0000739)1.75559468
180Congenital primary aphakia (HP:0007707)1.75527152
181Hypoglycemic seizures (HP:0002173)1.75280543
182Insomnia (HP:0100785)1.74923045
183Sacral dimple (HP:0000960)1.74552194
184Hypoplastic female external genitalia (HP:0012815)1.73747676
185Depression (HP:0000716)1.73742190
186Muscular hypotonia of the trunk (HP:0008936)1.73247150
187Eosinophilia (HP:0001880)1.72807645
188Bifid tongue (HP:0010297)1.72574549
189Recurrent bacterial skin infections (HP:0005406)1.72557635
190Acute hepatic failure (HP:0006554)1.72314702
191Sporadic (HP:0003745)1.72223046
192Tented upper lip vermilion (HP:0010804)1.71591298
193Reticulocytosis (HP:0001923)1.70216880
194Abnormality of the thoracic spine (HP:0100711)1.69896187
195Neutropenia (HP:0001875)1.69651372
196Increased muscle lipid content (HP:0009058)1.68231028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.04633079
2MAP4K14.65939044
3SIK34.37041343
4MAP3K93.83206302
5TAOK23.15349139
6TRIB33.07290318
7DYRK23.06994922
8MAP3K123.04712174
9TAOK32.96687710
10UHMK12.83428850
11SMG12.82489122
12BCR2.70283989
13SIK12.59136145
14MAPK132.56327275
15NTRK22.55664238
16WNK32.38033762
17KSR12.34611158
18MAPKAPK32.20438192
19MINK12.16139077
20LIMK12.15597983
21RIPK42.09081373
22MAP3K142.02957774
23NTRK32.02270802
24STK162.00844824
25TBK11.96642261
26VRK21.88555678
27CDK191.84740366
28ERBB31.84142671
29TNK21.82357020
30TAOK11.79878770
31TESK21.79613573
32IKBKE1.72513088
33BCKDK1.70524499
34PIM21.64421359
35ERN11.62628053
36FGFR41.59834945
37CDK121.59044782
38PRPF4B1.57450600
39IRAK41.56016784
40IRAK31.55279383
41NME21.51428522
42MAP2K61.46857738
43DAPK11.42073648
44ICK1.41799250
45MAP3K41.39972175
46TESK11.32350007
47EPHA31.31387269
48KDR1.28928196
49DYRK31.26217346
50IKBKB1.26150407
51MAPK111.23898453
52BMPR1B1.21882055
53TXK1.21004778
54DYRK1B1.20705777
55CSF1R1.18651677
56SIK21.18350363
57INSRR1.17346546
58MAP3K131.16575109
59MAP3K101.16028940
60MAP2K71.16019898
61MAPK151.14212166
62PASK1.13844554
63BTK1.10661251
64GRK61.08574630
65CAMKK11.04481349
66CDK181.00989952
67PRKD21.00849951
68DAPK20.99912427
69MAP3K110.99110410
70CDK50.98337146
71CDK80.96776701
72TYK20.96450513
73MAP2K30.96439236
74ARAF0.96371476
75PRKD30.94935324
76DYRK1A0.94261464
77EPHB20.91549504
78MAPKAPK50.90745683
79KSR20.90481931
80TNIK0.89118012
81KIT0.88988101
82CDK40.88876844
83CSNK1G30.88748356
84PRKCH0.87294798
85CSNK1G20.86156364
86CHUK0.84262339
87VRK10.83029164
88ACVR1B0.82555649
89FES0.80607714
90BRAF0.80025606
91MAP2K40.78774095
92CDK150.78296342
93EPHA20.78268994
94CDK140.77788809
95CDK70.77721861
96PAK60.77306647
97TYRO30.76623935
98CDK11A0.76583371
99PKN20.75291958
100CDK90.74351664
101RPS6KA20.73368986
102HIPK20.73234453
103MAP2K20.71861376
104TGFBR10.71504359
105JAK30.71352141
106EPHB10.69983821
107BRSK10.67885681
108LCK0.67075101
109CSNK1A1L0.66042202
110JAK10.65920558
111NTRK10.65528477
112PRKCQ0.64322616
113LYN0.63724682
114RPS6KB20.63447509
115PAK30.63053729
116CAMKK20.61716043
117CSNK1G10.60785812
118RIPK10.60274708
119MARK20.58475763
120MAPK120.56461015
121PRKCI0.54971482
122CASK0.54840339
123HCK0.54537849
124PHKG20.53812441
125PHKG10.53812441
126EEF2K0.53127393
127MAP3K70.52620680
128MAP3K20.51893690
129ITK0.51511147
130RPS6KC10.49517597
131RPS6KL10.49517597
132LRRK20.49235376
133PIM10.47040769
134EIF2AK20.46215597
135RPS6KA40.45177647
136RET0.44039328
137MAPK90.43921292
138MUSK0.43549730
139RPS6KA60.41276586
140MAP3K50.41034615
141CCNB10.40985542
142SYK0.40552287
143CDC42BPA0.39695945
144MAPK30.38966576
145NME10.38767382
146MTOR0.38128960
147PDK10.37478719
148GRK50.37341801
149MAP2K10.36955219
150ADRBK10.34187972
151PNCK0.30177844
152PRKCG0.29246731
153AURKA0.28906895
154PRKCZ0.27725527
155MAPK40.25122967
156MAP3K10.21844061
157YES10.19656538
158CAMK2B0.19417356
159MATK0.19395684
160GRK70.18846263
161PTK20.18642484
162ZAP700.18561144
163PDGFRA0.18513986
164FYN0.17956702
165ADRBK20.17929139
166BLK0.17081903
167TLK10.16384540

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.27990519
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.81028449
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.76838225
4Allograft rejection_Homo sapiens_hsa053303.36200618
5Autoimmune thyroid disease_Homo sapiens_hsa053203.24192165
6Synaptic vesicle cycle_Homo sapiens_hsa047212.85075421
7Asthma_Homo sapiens_hsa053102.73699625
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.72044415
9B cell receptor signaling pathway_Homo sapiens_hsa046622.70792784
10Graft-versus-host disease_Homo sapiens_hsa053322.68210091
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60263745
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.44625740
13Insulin secretion_Homo sapiens_hsa049112.22224285
14Nicotine addiction_Homo sapiens_hsa050332.20704097
15Vibrio cholerae infection_Homo sapiens_hsa051102.17055044
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.09333795
17N-Glycan biosynthesis_Homo sapiens_hsa005101.99401985
18Dopaminergic synapse_Homo sapiens_hsa047281.99012976
19Viral myocarditis_Homo sapiens_hsa054161.93757995
20Cocaine addiction_Homo sapiens_hsa050301.85626800
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85003957
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.82989714
23Acute myeloid leukemia_Homo sapiens_hsa052211.77530960
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.77367783
25Herpes simplex infection_Homo sapiens_hsa051681.76213797
26Measles_Homo sapiens_hsa051621.75760214
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.75015819
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74230365
29Epstein-Barr virus infection_Homo sapiens_hsa051691.70736593
30GABAergic synapse_Homo sapiens_hsa047271.68791759
31Antigen processing and presentation_Homo sapiens_hsa046121.68732045
32Base excision repair_Homo sapiens_hsa034101.63087771
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63018901
34Protein export_Homo sapiens_hsa030601.62081528
35Leishmaniasis_Homo sapiens_hsa051401.62012546
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59296138
37Cholinergic synapse_Homo sapiens_hsa047251.57998939
38Taste transduction_Homo sapiens_hsa047421.54739551
39Circadian entrainment_Homo sapiens_hsa047131.54402854
40Influenza A_Homo sapiens_hsa051641.54223776
41Serotonergic synapse_Homo sapiens_hsa047261.50252208
42Collecting duct acid secretion_Homo sapiens_hsa049661.45848738
43Amphetamine addiction_Homo sapiens_hsa050311.44225173
44Glutamatergic synapse_Homo sapiens_hsa047241.42125552
45Axon guidance_Homo sapiens_hsa043601.39145229
46Long-term potentiation_Homo sapiens_hsa047201.35747435
47Morphine addiction_Homo sapiens_hsa050321.33483835
48Hepatitis B_Homo sapiens_hsa051611.30458866
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.30259120
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26886099
51Ribosome_Homo sapiens_hsa030101.25898512
52GnRH signaling pathway_Homo sapiens_hsa049121.19691358
53Hepatitis C_Homo sapiens_hsa051601.19459789
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16018678
55Toxoplasmosis_Homo sapiens_hsa051451.14156134
56Regulation of autophagy_Homo sapiens_hsa041401.13335676
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12704972
58Type II diabetes mellitus_Homo sapiens_hsa049301.12609931
59Circadian rhythm_Homo sapiens_hsa047101.11615087
60Other glycan degradation_Homo sapiens_hsa005111.09688312
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09003358
62Colorectal cancer_Homo sapiens_hsa052101.08383632
63Endometrial cancer_Homo sapiens_hsa052131.07782463
64Olfactory transduction_Homo sapiens_hsa047401.07593210
65ErbB signaling pathway_Homo sapiens_hsa040121.07116639
66Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06163816
67Parkinsons disease_Homo sapiens_hsa050121.04754845
68Neurotrophin signaling pathway_Homo sapiens_hsa047221.03700030
69VEGF signaling pathway_Homo sapiens_hsa043701.02733476
70Oxidative phosphorylation_Homo sapiens_hsa001901.02604398
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02068725
72Apoptosis_Homo sapiens_hsa042101.01940754
73Prolactin signaling pathway_Homo sapiens_hsa049171.01912254
74Alcoholism_Homo sapiens_hsa050341.01019216
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00577649
76Notch signaling pathway_Homo sapiens_hsa043300.99113321
77Type I diabetes mellitus_Homo sapiens_hsa049400.98978095
78Sulfur metabolism_Homo sapiens_hsa009200.97624451
79Gap junction_Homo sapiens_hsa045400.97171486
80Phenylalanine metabolism_Homo sapiens_hsa003600.97111231
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96366805
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94591174
83Oocyte meiosis_Homo sapiens_hsa041140.94269846
84Butanoate metabolism_Homo sapiens_hsa006500.93373123
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91436975
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90688089
87Chronic myeloid leukemia_Homo sapiens_hsa052200.90565296
88HTLV-I infection_Homo sapiens_hsa051660.90337007
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89803272
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89221842
91Fructose and mannose metabolism_Homo sapiens_hsa000510.82473577
92TNF signaling pathway_Homo sapiens_hsa046680.81887093
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81672121
94Gastric acid secretion_Homo sapiens_hsa049710.80871245
95Estrogen signaling pathway_Homo sapiens_hsa049150.80165716
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79673922
97Cardiac muscle contraction_Homo sapiens_hsa042600.79662920
98Osteoclast differentiation_Homo sapiens_hsa043800.78425891
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77785510
100Alzheimers disease_Homo sapiens_hsa050100.77356417
101Oxytocin signaling pathway_Homo sapiens_hsa049210.77242160
102Viral carcinogenesis_Homo sapiens_hsa052030.75615594
103Tuberculosis_Homo sapiens_hsa051520.75612725
104DNA replication_Homo sapiens_hsa030300.75187939
105Long-term depression_Homo sapiens_hsa047300.73176584
106Huntingtons disease_Homo sapiens_hsa050160.72945101
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70682871
108Hematopoietic cell lineage_Homo sapiens_hsa046400.70614211
109Pancreatic secretion_Homo sapiens_hsa049720.69734908
110Endocytosis_Homo sapiens_hsa041440.69282971
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.69017420
112mRNA surveillance pathway_Homo sapiens_hsa030150.68339862
113Shigellosis_Homo sapiens_hsa051310.66614118
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66350227
115Insulin signaling pathway_Homo sapiens_hsa049100.65811584
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65196747
117Renin secretion_Homo sapiens_hsa049240.64877417
118T cell receptor signaling pathway_Homo sapiens_hsa046600.62966082
119Pyrimidine metabolism_Homo sapiens_hsa002400.62270909
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62150048
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62141735
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61860228
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60357877
124Sulfur relay system_Homo sapiens_hsa041220.59738938
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59249447
126Staphylococcus aureus infection_Homo sapiens_hsa051500.59237440
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58490059
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57376742
129Chemokine signaling pathway_Homo sapiens_hsa040620.55139975
130Phagosome_Homo sapiens_hsa041450.54612921
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52434672
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49410392
133Wnt signaling pathway_Homo sapiens_hsa043100.49349605
134Pancreatic cancer_Homo sapiens_hsa052120.48770239
135Melanogenesis_Homo sapiens_hsa049160.48462856
136Glioma_Homo sapiens_hsa052140.48416676
137Thyroid cancer_Homo sapiens_hsa052160.48240778
138Biosynthesis of amino acids_Homo sapiens_hsa012300.47913247
139Glucagon signaling pathway_Homo sapiens_hsa049220.47456799
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45700317
141Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45593416
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.44598205
143MAPK signaling pathway_Homo sapiens_hsa040100.44437550
144mTOR signaling pathway_Homo sapiens_hsa041500.44288600
145Choline metabolism in cancer_Homo sapiens_hsa052310.44044194
146Renal cell carcinoma_Homo sapiens_hsa052110.43835516
147Ras signaling pathway_Homo sapiens_hsa040140.43545646
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42372993
149Non-small cell lung cancer_Homo sapiens_hsa052230.41777326
150Thyroid hormone synthesis_Homo sapiens_hsa049180.41713263
151Prion diseases_Homo sapiens_hsa050200.41551171
152cAMP signaling pathway_Homo sapiens_hsa040240.41526975
153Rheumatoid arthritis_Homo sapiens_hsa053230.41326630
154Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40857512
155RNA polymerase_Homo sapiens_hsa030200.39772217
156Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39108784
157Spliceosome_Homo sapiens_hsa030400.39025720
158Homologous recombination_Homo sapiens_hsa034400.32555659
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.31295026
160Pentose phosphate pathway_Homo sapiens_hsa000300.27021233
161Sphingolipid signaling pathway_Homo sapiens_hsa040710.26895937
162AMPK signaling pathway_Homo sapiens_hsa041520.24596811
163Inositol phosphate metabolism_Homo sapiens_hsa005620.24375920
164NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23946440
165Central carbon metabolism in cancer_Homo sapiens_hsa052300.23862706
166Lysine degradation_Homo sapiens_hsa003100.23524759
167Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.22809379
168Non-homologous end-joining_Homo sapiens_hsa034500.22539022
169Small cell lung cancer_Homo sapiens_hsa052220.20583740
170Purine metabolism_Homo sapiens_hsa002300.20104389
171Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19564365

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