SALL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of chemokine secretion (GO:0090197)5.41242454
2presynaptic membrane assembly (GO:0097105)5.27273312
3regulation of posttranscriptional gene silencing (GO:0060147)5.26189069
4regulation of gene silencing by miRNA (GO:0060964)5.26189069
5regulation of gene silencing by RNA (GO:0060966)5.26189069
6regulation of chemokine secretion (GO:0090196)5.10375064
7G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.79556428
8paraxial mesoderm development (GO:0048339)4.78695596
9presynaptic membrane organization (GO:0097090)4.57570600
10microglial cell activation (GO:0001774)4.49098950
11positive regulation of SMAD protein import into nucleus (GO:0060391)4.38351894
12postsynaptic membrane organization (GO:0001941)4.23440311
13pre-miRNA processing (GO:0031054)3.97568025
14L-phenylalanine catabolic process (GO:0006559)3.90253624
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.90253624
16anterior/posterior axis specification, embryo (GO:0008595)3.76326279
17lateral sprouting from an epithelium (GO:0060601)3.74312112
18L-phenylalanine metabolic process (GO:0006558)3.74096501
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.74096501
20glycine metabolic process (GO:0006544)3.62077790
21convergent extension (GO:0060026)3.53584578
22G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.49802243
23determination of adult lifespan (GO:0008340)3.45069510
24regulation of SMAD protein import into nucleus (GO:0060390)3.44245107
25serine family amino acid catabolic process (GO:0009071)3.42813492
26nuclear pore organization (GO:0006999)3.27841167
27regulation of hippo signaling (GO:0035330)3.26202299
28aromatic amino acid family catabolic process (GO:0009074)3.24023318
29pyrimidine nucleobase catabolic process (GO:0006208)3.18502522
30cellular response to cholesterol (GO:0071397)3.16246905
31serine family amino acid biosynthetic process (GO:0009070)3.06894097
32somatic stem cell division (GO:0048103)3.06450139
33histone H4-K12 acetylation (GO:0043983)3.05229249
34serine family amino acid metabolic process (GO:0009069)3.04565943
35protein localization to kinetochore (GO:0034501)3.03725744
36neuron cell-cell adhesion (GO:0007158)3.03443245
37female genitalia development (GO:0030540)3.01291250
38DNA unwinding involved in DNA replication (GO:0006268)3.00510279
39negative regulation of glial cell differentiation (GO:0045686)2.99212027
40sodium-independent organic anion transport (GO:0043252)2.96430700
41regulation of timing of cell differentiation (GO:0048505)2.93598162
42glyoxylate metabolic process (GO:0046487)2.93303249
43regulation of development, heterochronic (GO:0040034)2.91913019
44establishment of apical/basal cell polarity (GO:0035089)2.89009313
45regulation of cell fate specification (GO:0042659)2.88857007
46regulation of helicase activity (GO:0051095)2.88795655
47lung-associated mesenchyme development (GO:0060484)2.88720068
48thyroid hormone generation (GO:0006590)2.88140990
49bile acid and bile salt transport (GO:0015721)2.88113845
50positive regulation by host of viral transcription (GO:0043923)2.85679218
51planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83572430
52cell-cell junction maintenance (GO:0045217)2.83027043
53axon extension involved in axon guidance (GO:0048846)2.81155204
54neuron projection extension involved in neuron projection guidance (GO:1902284)2.81155204
55cellular modified amino acid catabolic process (GO:0042219)2.80115039
56vagina development (GO:0060068)2.79708455
57G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.78914407
58notochord development (GO:0030903)2.78262304
59otic vesicle formation (GO:0030916)2.77888527
60cysteine metabolic process (GO:0006534)2.74548106
61regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.74340885
62anterior/posterior axis specification (GO:0009948)2.74309675
63L-serine metabolic process (GO:0006563)2.73825023
64negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73804735
65negative regulation of translation, ncRNA-mediated (GO:0040033)2.73804735
66regulation of translation, ncRNA-mediated (GO:0045974)2.73804735
67kynurenine metabolic process (GO:0070189)2.73706857
68DNA replication-dependent nucleosome assembly (GO:0006335)2.73683264
69DNA replication-dependent nucleosome organization (GO:0034723)2.73683264
70apical protein localization (GO:0045176)2.73346952
71IMP biosynthetic process (GO:0006188)2.72070755
72establishment of integrated proviral latency (GO:0075713)2.71928928
73midgut development (GO:0007494)2.71895651
74chromatin remodeling at centromere (GO:0031055)2.71637658
75sulfur amino acid catabolic process (GO:0000098)2.71136900
76purinergic nucleotide receptor signaling pathway (GO:0035590)2.71071696
77tryptophan catabolic process (GO:0006569)2.69823304
78indole-containing compound catabolic process (GO:0042436)2.69823304
79indolalkylamine catabolic process (GO:0046218)2.69823304
80digestive tract morphogenesis (GO:0048546)2.69024064
81negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.68773197
82folic acid-containing compound biosynthetic process (GO:0009396)2.68625953
83cell surface receptor signaling pathway involved in heart development (GO:0061311)2.67140635
84cell junction maintenance (GO:0034331)2.67040052
85establishment of nucleus localization (GO:0040023)2.65834433
86nuclear pore complex assembly (GO:0051292)2.65482701
87response to nitrosative stress (GO:0051409)2.63681215
88limb bud formation (GO:0060174)2.63659186
89regulation of stem cell maintenance (GO:2000036)2.63280716
90* cranial nerve development (GO:0021545)2.62102818
91negative regulation of histone methylation (GO:0031061)2.61287895
92negative regulation of astrocyte differentiation (GO:0048712)2.61125420
93imidazole-containing compound metabolic process (GO:0052803)2.60061580
94negative regulation of cholesterol transport (GO:0032375)2.59814640
95negative regulation of sterol transport (GO:0032372)2.59814640
96tryptophan metabolic process (GO:0006568)2.59061235
97positive regulation of neuroblast proliferation (GO:0002052)2.58212726
98generation of neurons (GO:0048699)2.57977326
99alpha-linolenic acid metabolic process (GO:0036109)2.57285272
100regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56723642
101dorsal/ventral axis specification (GO:0009950)2.56409408
102negative regulation of oligodendrocyte differentiation (GO:0048715)2.56272166
103ectodermal placode formation (GO:0060788)2.56144731
104CENP-A containing nucleosome assembly (GO:0034080)2.55843082
105pore complex assembly (GO:0046931)2.54588885
106regulation of gene silencing (GO:0060968)2.54430036
107cochlea morphogenesis (GO:0090103)2.54394814
108urea metabolic process (GO:0019627)2.54134156
109urea cycle (GO:0000050)2.54134156
110triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.54086578
111negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.53108363
112cell migration involved in gastrulation (GO:0042074)2.52072813
113glutamate metabolic process (GO:0006536)2.52033632
114heterochromatin organization (GO:0070828)2.52013660
115alpha-amino acid catabolic process (GO:1901606)2.51855792
116regulation of translational fidelity (GO:0006450)2.51807746
117amino acid import (GO:0043090)2.51700684
118ventricular trabecula myocardium morphogenesis (GO:0003222)2.50858406
119Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.50493690
120mitochondrial DNA metabolic process (GO:0032042)2.48770605
121stem cell division (GO:0017145)2.48073610
122spinal cord development (GO:0021510)2.47789625
123DNA replication-independent nucleosome assembly (GO:0006336)2.46567219
124DNA replication-independent nucleosome organization (GO:0034724)2.46567219
125neuronal stem cell maintenance (GO:0097150)2.46277106
126tetrahydrofolate metabolic process (GO:0046653)2.45910406
127protein complex localization (GO:0031503)2.45586127
128tongue development (GO:0043586)2.45348508
129macrophage activation involved in immune response (GO:0002281)2.45165071
130mitotic metaphase plate congression (GO:0007080)2.45114607
131regulation of non-canonical Wnt signaling pathway (GO:2000050)2.44387178
132sister chromatid segregation (GO:0000819)2.44076187
133negative regulation of mRNA processing (GO:0050686)2.44065706
134somatic hypermutation of immunoglobulin genes (GO:0016446)2.43366995
135somatic diversification of immune receptors via somatic mutation (GO:0002566)2.43366995
136establishment or maintenance of monopolar cell polarity (GO:0061339)2.42399804
137establishment of monopolar cell polarity (GO:0061162)2.42399804
138DNA damage response, detection of DNA damage (GO:0042769)2.42145667
139axon ensheathment in central nervous system (GO:0032291)2.41823768
140central nervous system myelination (GO:0022010)2.41823768
141glucocorticoid receptor signaling pathway (GO:0042921)2.41501304
142embryonic retina morphogenesis in camera-type eye (GO:0060059)2.41465546
143protein localization to chromosome, centromeric region (GO:0071459)2.41127519
144nodal signaling pathway (GO:0038092)2.40970423
145negative regulation of fibrinolysis (GO:0051918)2.40801750
146lysine metabolic process (GO:0006553)2.40798394
147lysine catabolic process (GO:0006554)2.40798394
148negative regulation of granulocyte differentiation (GO:0030853)2.40564645
149cellular amino acid catabolic process (GO:0009063)2.39608283
150vocalization behavior (GO:0071625)2.39515281
151proximal/distal pattern formation (GO:0009954)2.39257776
152axonal fasciculation (GO:0007413)2.38725510
153* mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.38231133
154positive regulation of catenin import into nucleus (GO:0035413)2.38208235
155regulation of establishment of planar polarity (GO:0090175)2.38190079
156L-amino acid import (GO:0043092)2.36667762
157cellular response to sterol (GO:0036315)2.35692747
158heart valve formation (GO:0003188)2.35235791
159histone exchange (GO:0043486)2.34602855
160mitotic sister chromatid segregation (GO:0000070)2.34529073
161ATP-dependent chromatin remodeling (GO:0043044)2.34384250
162somite development (GO:0061053)2.32287653
163protein localization to synapse (GO:0035418)2.31279392
164mitotic sister chromatid cohesion (GO:0007064)2.31186898
165inner ear receptor cell development (GO:0060119)2.31185052
166metaphase plate congression (GO:0051310)2.30899154
167dermatan sulfate biosynthetic process (GO:0030208)2.29799969
168regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.28624990
169establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.28334885
170non-canonical Wnt signaling pathway (GO:0035567)2.27757800
171cerebral cortex radially oriented cell migration (GO:0021799)2.25450076
172* cell-cell signaling involved in cell fate commitment (GO:0045168)2.25352557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.83943182
2* KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.61997732
3* KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.61997732
4* KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.61997732
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.55518106
6POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.53553427
7* NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.48797819
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.34254520
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.29651124
10TCF3_18692474_ChIP-Seq_MEFs_Mouse3.29262018
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.26125794
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.20724239
13* NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.10691640
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09527066
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.04061401
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.90275234
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.85087784
18TCF3_18692474_ChIP-Seq_MESCs_Mouse2.74397339
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.53859711
20EZH2_22144423_ChIP-Seq_EOC_Human2.52838997
21* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.51194067
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.44870018
23* SOX2_18555785_ChIP-Seq_MESCs_Mouse2.40964086
24* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.31038312
25RXR_22158963_ChIP-Seq_LIVER_Mouse2.26701754
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25738728
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.19702354
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14406094
29* POU5F1_16518401_ChIP-PET_MESCs_Mouse2.13898842
30* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.11767898
31* MYC_18555785_ChIP-Seq_MESCs_Mouse2.11522275
32MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08790498
33* NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.00413631
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98475402
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.94436457
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.92924963
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90447594
38* LXR_22158963_ChIP-Seq_LIVER_Mouse1.84429936
39AR_21909140_ChIP-Seq_LNCAP_Human1.79940859
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79420719
41* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.79385172
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.79200917
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.79050831
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78438758
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77768078
46* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73904217
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72408225
48GBX2_23144817_ChIP-Seq_PC3_Human1.71180415
49SOX2_18692474_ChIP-Seq_MEFs_Mouse1.71071187
50SOX2_18692474_ChIP-Seq_MESCs_Mouse1.69269543
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.68238003
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.68024503
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66458552
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66186251
55* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65609807
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64685551
57TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.64058522
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62149724
59* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60783531
60* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.58021955
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55193019
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55193019
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.54948792
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53706708
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52909087
66* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.52756525
67POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.51222170
68* ISL1_27105846_Chip-Seq_CPCs_Mouse1.51138329
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.49553884
70* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49362866
71* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.48621952
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47244698
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46384606
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43899623
75* P300_19829295_ChIP-Seq_ESCs_Human1.43839244
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42253390
77* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.40870603
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.40778546
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.40426858
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38801100
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37998193
82* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36151735
83* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36151735
84FUS_26573619_Chip-Seq_HEK293_Human1.35143992
85* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34680462
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.34552694
87EWS_26573619_Chip-Seq_HEK293_Human1.34227177
88SOX9_26525672_Chip-Seq_HEART_Mouse1.29992914
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29296504
90* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28823291
91RNF2_27304074_Chip-Seq_NSC_Mouse1.28724929
92IRF1_19129219_ChIP-ChIP_H3396_Human1.28689206
93AR_21572438_ChIP-Seq_LNCaP_Human1.28110300
94NANOG_21062744_ChIP-ChIP_HESCs_Human1.27811103
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26544440
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26441803
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25644325
98MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25184595
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24736903
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24615652
101SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24193178
102SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23230329
103* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23050507
104* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.20456583
105* RING1B_27294783_Chip-Seq_ESCs_Mouse1.19638438
106* RING1B_27294783_Chip-Seq_NPCs_Mouse1.19234579
107* NANOG_16518401_ChIP-PET_MESCs_Mouse1.18991403
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18742690
109TAF15_26573619_Chip-Seq_HEK293_Human1.18426551
110* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18022038
111* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17871540
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17515668
113* SMAD3_21741376_ChIP-Seq_EPCs_Human1.17002914
114* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.16578814
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16009789
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15710205
117* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14025001
118MYC_22102868_ChIP-Seq_BL_Human1.13772109
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13683019
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13509254
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12055469
122MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11955681
123* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11752080
124* NANOG_16153702_ChIP-ChIP_HESCs_Human1.11043097
125* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10242066
126* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09777886
127ESR2_21235772_ChIP-Seq_MCF-7_Human1.08965582
128PIAS1_25552417_ChIP-Seq_VCAP_Human1.08258115
129ESR1_21235772_ChIP-Seq_MCF-7_Human1.06871519
130SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06528170
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05835876
132* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05584933
133* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03667624
134* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03141375
135* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02909161
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02358594
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02139426
138* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01511162
139ZNF274_21170338_ChIP-Seq_K562_Hela1.01198962
140* SOX2_16153702_ChIP-ChIP_HESCs_Human1.00727228
141JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00474881
142* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99342505
143CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98829526
144KAP1_27257070_Chip-Seq_ESCs_Mouse0.98748254
145E2F1_21310950_ChIP-Seq_MCF-7_Human0.97843860
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96253386
147* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95627007
148XRN2_22483619_ChIP-Seq_HELA_Human0.95043941
149EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91501931
150MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91435863
151NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91373963
152CLOCK_20551151_ChIP-Seq_293T_Human0.91369571
153KDM5A_27292631_Chip-Seq_BREAST_Human0.90110910
154* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89134164
155ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88946168
156* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85723728
157* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85391748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.55585096
2MP0005085_abnormal_gallbladder_physiolo3.49653306
3MP0003191_abnormal_cellular_cholesterol3.28151651
4MP0002139_abnormal_hepatobiliary_system3.20753620
5MP0005360_urolithiasis2.94655444
6MP0003806_abnormal_nucleotide_metabolis2.93954886
7MP0010030_abnormal_orbit_morphology2.86029819
8MP0003252_abnormal_bile_duct2.78416106
9MP0004133_heterotaxia2.57597717
10MP0000566_synostosis2.53564906
11MP0000778_abnormal_nervous_system2.38793373
12MP0003890_abnormal_embryonic-extraembry2.20752875
13MP0002249_abnormal_larynx_morphology2.14766578
14MP0008057_abnormal_DNA_replication2.10580125
15MP0009840_abnormal_foam_cell2.05295967
16MP0005365_abnormal_bile_salt2.05170350
17MP0003283_abnormal_digestive_organ1.98734551
18MP0006082_CNS_inflammation1.96955199
19MP0003880_abnormal_central_pattern1.89470481
20MP0001299_abnormal_eye_distance/1.87499318
21MP0008007_abnormal_cellular_replicative1.78306294
22MP0003690_abnormal_glial_cell1.76627691
23MP0008875_abnormal_xenobiotic_pharmacok1.74631462
24MP0002938_white_spotting1.72389181
25MP0010094_abnormal_chromosome_stability1.72178042
26MP0001915_intracranial_hemorrhage1.71904179
27MP0004859_abnormal_synaptic_plasticity1.67329637
28MP0001293_anophthalmia1.64692676
29MP0003123_paternal_imprinting1.62148200
30MP0006292_abnormal_olfactory_placode1.60004073
31MP0003938_abnormal_ear_development1.59268773
32MP0003119_abnormal_digestive_system1.58380271
33MP0002084_abnormal_developmental_patter1.58165418
34MP0004957_abnormal_blastocyst_morpholog1.57499838
35* MP0005380_embryogenesis_phenotype1.56893090
36* MP0001672_abnormal_embryogenesis/_devel1.56893090
37MP0003077_abnormal_cell_cycle1.56878688
38MP0003111_abnormal_nucleus_morphology1.56304932
39MP0009672_abnormal_birth_weight1.56108592
40* MP0002085_abnormal_embryonic_tissue1.55329673
41MP0002697_abnormal_eye_size1.53439036
42MP0008058_abnormal_DNA_repair1.51644970
43MP0001346_abnormal_lacrimal_gland1.50823118
44MP0005670_abnormal_white_adipose1.45101080
45MP0002092_abnormal_eye_morphology1.44577053
46MP0001730_embryonic_growth_arrest1.44492030
47MP0002111_abnormal_tail_morphology1.44234239
48MP0001849_ear_inflammation1.39449577
49MP0004197_abnormal_fetal_growth/weight/1.39262854
50MP0003567_abnormal_fetal_cardiomyocyte1.39157015
51* MP0002088_abnormal_embryonic_growth/wei1.35733000
52* MP0003984_embryonic_growth_retardation1.35602577
53MP0003937_abnormal_limbs/digits/tail_de1.34514606
54MP0000955_abnormal_spinal_cord1.31754286
55MP0000631_abnormal_neuroendocrine_gland1.31680028
56MP0000049_abnormal_middle_ear1.30833127
57MP0001529_abnormal_vocalization1.30756323
58MP0003693_abnormal_embryo_hatching1.30549609
59MP0003172_abnormal_lysosome_physiology1.29928653
60MP0004019_abnormal_vitamin_homeostasis1.29730991
61MP0003136_yellow_coat_color1.27169423
62* MP0009053_abnormal_anal_canal1.26898748
63MP0003122_maternal_imprinting1.26200134
64MP0001177_atelectasis1.25242904
65MP0002086_abnormal_extraembryonic_tissu1.24080546
66MP0001286_abnormal_eye_development1.23745104
67MP0001697_abnormal_embryo_size1.23099491
68MP0005332_abnormal_amino_acid1.22494328
69MP0005377_hearing/vestibular/ear_phenot1.22145579
70MP0003878_abnormal_ear_physiology1.22145579
71MP0001984_abnormal_olfaction1.21280102
72* MP0000350_abnormal_cell_proliferation1.20823030
73MP0000537_abnormal_urethra_morphology1.20543345
74MP0005394_taste/olfaction_phenotype1.19270595
75MP0005499_abnormal_olfactory_system1.19270595
76MP0009703_decreased_birth_body1.17448407
77MP0003115_abnormal_respiratory_system1.17323656
78* MP0002152_abnormal_brain_morphology1.16381184
79MP0008932_abnormal_embryonic_tissue1.15934348
80MP0009250_abnormal_appendicular_skeleto1.15921587
81MP0003705_abnormal_hypodermis_morpholog1.15443497
82MP0000579_abnormal_nail_morphology1.14178855
83MP0005058_abnormal_lysosome_morphology1.13869985
84MP0002736_abnormal_nociception_after1.13429302
85MP0005187_abnormal_penis_morphology1.12523343
86MP0008789_abnormal_olfactory_epithelium1.12049963
87MP0010352_gastrointestinal_tract_polyps1.10823102
88MP0002254_reproductive_system_inflammat1.08285714
89MP0001485_abnormal_pinna_reflex1.08032599
90MP0000762_abnormal_tongue_morphology1.06536239
91MP0005391_vision/eye_phenotype1.04934236
92* MP0003942_abnormal_urinary_system1.04318775
93MP0001486_abnormal_startle_reflex1.03031670
94MP0000432_abnormal_head_morphology1.02221978
95MP0004270_analgesia1.01802389
96MP0000026_abnormal_inner_ear1.01788488
97MP0002751_abnormal_autonomic_nervous1.01496369
98MP0005248_abnormal_Harderian_gland1.01487369
99MP0009384_cardiac_valve_regurgitation1.01396263
100MP0004272_abnormal_basement_membrane1.00374886
101MP0010678_abnormal_skin_adnexa0.98765279
102MP0003941_abnormal_skin_development0.98203976
103* MP0003861_abnormal_nervous_system0.96965100
104MP0003718_maternal_effect0.95832396
105MP0002932_abnormal_joint_morphology0.95611733
106MP0004858_abnormal_nervous_system0.95288788
107* MP0002081_perinatal_lethality0.94987924
108MP0005023_abnormal_wound_healing0.94634734
109MP0003121_genomic_imprinting0.93565301
110MP0003635_abnormal_synaptic_transmissio0.92519443
111MP0005076_abnormal_cell_differentiation0.91955879
112MP0004885_abnormal_endolymph0.91528370
113MP0003755_abnormal_palate_morphology0.89561479
114MP0000428_abnormal_craniofacial_morphol0.89137697
115* MP0002080_prenatal_lethality0.88263861
116MP0008877_abnormal_DNA_methylation0.87211171
117MP0005423_abnormal_somatic_nervous0.86926327
118MP0005647_abnormal_sex_gland0.86054040
119MP0002928_abnormal_bile_duct0.85988945
120MP0003315_abnormal_perineum_morphology0.85795214
121MP0010329_abnormal_lipoprotein_level0.84988056
122MP0000383_abnormal_hair_follicle0.84363194
123MP0005257_abnormal_intraocular_pressure0.83958913
124MP0002282_abnormal_trachea_morphology0.83946375
125MP0002734_abnormal_mechanical_nocicepti0.83934547
126MP0000678_abnormal_parathyroid_gland0.83711861
127MP0005367_renal/urinary_system_phenotyp0.83572579
128MP0000516_abnormal_urinary_system0.83572579
129MP0002882_abnormal_neuron_morphology0.83033534
130MP0004264_abnormal_extraembryonic_tissu0.82305937
131MP0000609_abnormal_liver_physiology0.82240829
132MP0000647_abnormal_sebaceous_gland0.82226593
133MP0002557_abnormal_social/conspecific_i0.81852545
134MP0002925_abnormal_cardiovascular_devel0.81553897
135MP0000462_abnormal_digestive_system0.79634063
136MP0002233_abnormal_nose_morphology0.79264775
137* MP0000534_abnormal_ureter_morphology0.78442059
138MP0002116_abnormal_craniofacial_bone0.78364692
139MP0003385_abnormal_body_wall0.76934570
140MP0003935_abnormal_craniofacial_develop0.74543840
141MP0005666_abnormal_adipose_tissue0.73401602
142MP0003936_abnormal_reproductive_system0.71106104
143MP0005167_abnormal_blood-brain_barrier0.70699152

Predicted human phenotypes

RankGene SetZ-score
1Glomerulonephritis (HP:0000099)5.16773072
2Systemic lupus erythematosus (HP:0002725)4.85520932
3Complement deficiency (HP:0004431)4.51804102
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.47397125
5Rib fusion (HP:0000902)3.41948579
6Ependymoma (HP:0002888)3.34977525
7Esophageal atresia (HP:0002032)3.34698693
8Agnosia (HP:0010524)3.28057070
9Upper motor neuron abnormality (HP:0002127)3.21564869
10Intrahepatic cholestasis (HP:0001406)3.20566002
11Abnormality of complement system (HP:0005339)3.08641161
12Pseudobulbar signs (HP:0002200)3.02627491
13Abnormality of pyrimidine metabolism (HP:0004353)2.96034023
14Hypobetalipoproteinemia (HP:0003563)2.88961745
15Abnormality of the labia minora (HP:0012880)2.84632485
16Choanal stenosis (HP:0000452)2.82732364
17Aplasia/Hypoplasia of the sternum (HP:0006714)2.81473416
18Cortical dysplasia (HP:0002539)2.78482715
19Trigonocephaly (HP:0000243)2.74700003
20Orthostatic hypotension (HP:0001278)2.71255171
21Abnormal lung lobation (HP:0002101)2.71154374
22Increased nuchal translucency (HP:0010880)2.70923718
23Astrocytoma (HP:0009592)2.69027378
24Abnormality of the astrocytes (HP:0100707)2.69027378
25Spastic diplegia (HP:0001264)2.65432818
26Cutaneous finger syndactyly (HP:0010554)2.63738663
27Absent septum pellucidum (HP:0001331)2.62579853
28Absent radius (HP:0003974)2.60798303
29Abnormal number of incisors (HP:0011064)2.60550753
30Maternal diabetes (HP:0009800)2.59306270
31Anophthalmia (HP:0000528)2.59157275
32Short 4th metacarpal (HP:0010044)2.57328943
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57328943
34Aplasia involving forearm bones (HP:0009822)2.57198596
35Absent forearm bone (HP:0003953)2.57198596
36Hyperglycinemia (HP:0002154)2.51439281
37High anterior hairline (HP:0009890)2.50767695
38Deep venous thrombosis (HP:0002625)2.50443279
39Abnormality of the 4th metacarpal (HP:0010012)2.50301858
40Cutaneous syndactyly (HP:0012725)2.49925780
41Hepatoblastoma (HP:0002884)2.49544056
42Retinal atrophy (HP:0001105)2.49416459
43Megalencephaly (HP:0001355)2.48421015
44Bronchomalacia (HP:0002780)2.47341633
45Midline defect of the nose (HP:0004122)2.47338434
46Supernumerary spleens (HP:0009799)2.45803338
47Hyperglycinuria (HP:0003108)2.44960542
48Shawl scrotum (HP:0000049)2.44081300
49Hemivertebrae (HP:0002937)2.41807877
50Abnormality of liposaccharide metabolism (HP:0010968)2.40313937
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.40313937
52Abnormality of glycolipid metabolism (HP:0010969)2.40313937
53Abnormality of the middle phalanges of the toes (HP:0010183)2.39891783
54Arterial tortuosity (HP:0005116)2.38168780
55Medulloblastoma (HP:0002885)2.36805133
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36412009
57Supernumerary ribs (HP:0005815)2.36094656
58Neoplasm of the oral cavity (HP:0100649)2.35856951
59Abnormality of sulfur amino acid metabolism (HP:0004339)2.35076775
60Stenosis of the external auditory canal (HP:0000402)2.33576369
61Optic nerve hypoplasia (HP:0000609)2.31569468
62Aqueductal stenosis (HP:0002410)2.30975754
63Abnormality of the septum pellucidum (HP:0007375)2.30721251
64Septo-optic dysplasia (HP:0100842)2.29081037
65Nephritis (HP:0000123)2.28905588
66Shallow orbits (HP:0000586)2.28561399
67Abnormality of glycine metabolism (HP:0010895)2.28473512
68Abnormality of serine family amino acid metabolism (HP:0010894)2.28473512
69Aplasia involving bones of the extremities (HP:0009825)2.27633090
70Aplasia involving bones of the upper limbs (HP:0009823)2.27633090
71Aplasia of the phalanges of the hand (HP:0009802)2.27633090
72Myelomeningocele (HP:0002475)2.25891953
73Abnormality of the salivary glands (HP:0010286)2.23715129
74* Arnold-Chiari malformation (HP:0002308)2.23448632
75Supernumerary bones of the axial skeleton (HP:0009144)2.23206250
76Renal duplication (HP:0000075)2.23170804
77Bifid tongue (HP:0010297)2.20582335
78Overriding aorta (HP:0002623)2.16834817
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14376558
80Glioma (HP:0009733)2.13335447
81* Gastrointestinal atresia (HP:0002589)2.12719042
82Back pain (HP:0003418)2.10062077
83Erectile abnormalities (HP:0100639)2.09792354
84Vitreoretinal degeneration (HP:0000655)2.08043201
85* Preaxial foot polydactyly (HP:0001841)2.05670613
86Bilateral microphthalmos (HP:0007633)2.04958984
87Abnormality of methionine metabolism (HP:0010901)2.04540240
88Rhabdomyosarcoma (HP:0002859)2.04252158
89Cerebral aneurysm (HP:0004944)2.03128611
90Abnormality of the diencephalon (HP:0010662)2.02943273
91Vertebral fusion (HP:0002948)2.02727164
92Broad metatarsal (HP:0001783)2.01615601
93Impulsivity (HP:0100710)2.01426329
94Morphological abnormality of the inner ear (HP:0011390)2.01168061
95Hypolipoproteinemia (HP:0010981)2.00557974
96* Renal hypoplasia (HP:0000089)1.99319793
97Short humerus (HP:0005792)1.97404742
98Coronal craniosynostosis (HP:0004440)1.96276292
99Disproportionate tall stature (HP:0001519)1.96071991
100Missing ribs (HP:0000921)1.93081564
101Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92841007
102Omphalocele (HP:0001539)1.92397659
103Meckel diverticulum (HP:0002245)1.91601964
104* Broad thumb (HP:0011304)1.91419044
105* Intestinal fistula (HP:0100819)1.90396964
106Short hallux (HP:0010109)1.90316839
107Neoplasm of striated muscle (HP:0009728)1.90251003
108Colon cancer (HP:0003003)1.89064712
109Oligodactyly (HP:0012165)1.88993289
110Abnormality of cochlea (HP:0000375)1.87272727
111Vascular tortuosity (HP:0004948)1.86969804
112Aplasia/hypoplasia of the humerus (HP:0006507)1.85980151
113Embryonal renal neoplasm (HP:0011794)1.84946265
114* Anal stenosis (HP:0002025)1.84586880
115* Abnormality of the antihelix (HP:0009738)1.84293234
116Neonatal short-limb short stature (HP:0008921)1.84117017
117Breast aplasia (HP:0100783)1.82543583
118Turricephaly (HP:0000262)1.81101250
119Abnormality of the ileum (HP:0001549)1.81071172
120Aplasia/Hypoplasia of the breasts (HP:0010311)1.80353309
121* Rectovaginal fistula (HP:0000143)1.79179727
122* Rectal fistula (HP:0100590)1.79179727
123Neoplasm of the liver (HP:0002896)1.78751020
124Synostosis involving the elbow (HP:0003938)1.78749291
125Humeroradial synostosis (HP:0003041)1.78749291
126Dysphonia (HP:0001618)1.78454229
127Aplasia/Hypoplasia of the hallux (HP:0008362)1.78007948
128Spinal muscular atrophy (HP:0007269)1.77366668
129Enlarged kidneys (HP:0000105)1.76648408
130Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.75556881
131Short 1st metacarpal (HP:0010034)1.75556881
132Synostosis of carpal bones (HP:0005048)1.75177841
133Skull defect (HP:0001362)1.74761571
134Abnormality of the incisor (HP:0000676)1.73933463
135Volvulus (HP:0002580)1.71368988
136Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.70344173
137Oligodactyly (hands) (HP:0001180)1.70043089
138Nephroblastoma (Wilms tumor) (HP:0002667)1.70040086
139* Vaginal fistula (HP:0004320)1.69566578
140Abnormality of the lower motor neuron (HP:0002366)1.68951752
141Hypochromic microcytic anemia (HP:0004840)1.68519719
142Short middle phalanx of finger (HP:0005819)1.66724665
143Depressed nasal tip (HP:0000437)1.66011328
144Holoprosencephaly (HP:0001360)1.65398865
145Hyperammonemia (HP:0001987)1.65247673
146Abnormality of the phalanges of the 2nd finger (HP:0009541)1.64177558
147Malignant gastrointestinal tract tumors (HP:0006749)1.63289467
148Gastrointestinal carcinoma (HP:0002672)1.63289467
149Patellar aplasia (HP:0006443)1.62736783
150Breast hypoplasia (HP:0003187)1.61722454
151Vertebral clefting (HP:0008428)1.61716371
152Broad alveolar ridges (HP:0000187)1.61576118
153Anomalous pulmonary venous return (HP:0010772)1.61400544
154Bicornuate uterus (HP:0000813)1.60098582
155Micropenis (HP:0000054)1.58471349
156Renovascular hypertension (HP:0100817)1.58115611
157Broad toe (HP:0001837)1.57999243
158Abnormality of the aortic arch (HP:0012303)1.56785784
159Vaginal atresia (HP:0000148)1.56246585
160Morphological abnormality of the middle ear (HP:0008609)1.56228680
161Vertebral arch anomaly (HP:0008438)1.55484153
162Abnormality of the carotid arteries (HP:0005344)1.54756315
163* Broad finger (HP:0001500)1.54332854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.54824346
2TSSK63.86960446
3MAPK153.43155693
4CDK123.25897841
5PDK22.55665398
6TTK2.46181148
7PAK42.42320546
8EPHA22.38997343
9CASK2.38976921
10ICK2.38953403
11MKNK12.33614114
12EPHA42.28475671
13CDC72.02738860
14NTRK22.02674179
15CAMK1D1.99548054
16CSF1R1.95469053
17TAF11.95007276
18MKNK21.91888680
19MARK11.88648675
20TNIK1.81187273
21EPHB21.78397115
22PLK41.73391235
23MAP3K101.72592579
24PBK1.62967863
25DYRK21.60258364
26BCR1.59176973
27BUB11.54061563
28PASK1.51788258
29LATS11.48477421
30STK101.43903160
31AKT31.43436688
32WEE11.41315029
33CLK11.38948481
34VRK21.38822866
35GRK71.38744244
36CAMK1G1.36815631
37PKN21.36790995
38MET1.35308437
39PLK31.29541070
40NEK91.29337513
41NEK11.29022203
42MTOR1.27559769
43PNCK1.25428576
44VRK11.24970304
45BRD41.22061486
46CDK61.21105353
47FGFR21.20508882
48ERBB41.20062932
49MAP3K81.17623492
50NTRK11.17433922
51PAK21.17097897
52NEK61.14476132
53MAPK71.11252575
54RPS6KB21.10460765
55PDGFRA1.08161949
56MATK1.07743625
57CDK71.06226299
58UHMK11.04393158
59CDK41.02711488
60LATS21.01786607
61MELK1.00790754
62PRKD31.00260023
63NTRK30.98890266
64PLK20.97210850
65NEK20.95209700
66PKN10.94960769
67BRSK20.94960269
68BCKDK0.94272151
69ATR0.91856462
70PLK10.91141641
71FGFR10.90718077
72CAMK40.90383948
73BMPR1B0.87021703
74TRIM280.85641311
75STK38L0.85463012
76CHEK20.84729227
77MAP3K90.83279496
78CSNK1G20.82341320
79PAK60.81691266
80SGK2230.80908954
81SGK4940.80908954
82ZAK0.78976177
83CDK20.78572450
84BRSK10.77422376
85ALK0.76364146
86CHEK10.76167133
87MAP3K40.71973938
88OXSR10.71523496
89GSK3A0.70978503
90TESK20.70346798
91SGK20.70295082
92FLT30.69862606
93EEF2K0.67908414
94SIK10.66925110
95DYRK1A0.66551795
96WNK30.65511748
97YES10.64586258
98ERBB20.63882908
99ATM0.63611072
100NUAK10.62960718
101PTK60.62157222
102PRKCG0.61851097
103EPHA30.61837311
104MAP2K20.61829293
105ERN10.61627704
106CDK180.60858338
107CDK150.60748399
108STK40.59596629
109BMX0.58620030
110KSR10.58589801
111CSNK1A1L0.58251235
112CSNK1D0.57684253
113CDK30.56574683
114CDK11A0.56061713
115CSNK1E0.55258205
116TYRO30.53494739
117DDR20.53076464
118CDK10.52928688
119TGFBR10.52069214
120STK30.51440021
121DMPK0.51225762
122CDK80.48625410
123MINK10.48508833
124EIF2AK20.48412556
125DYRK30.48124750
126MAPK140.47820124
127ROCK20.47800865
128CDK140.47078202
129AURKA0.46470605
130MAPK120.44898230
131DYRK1B0.43206353
132CSNK1G30.42673934
133SRPK10.42218765
134FGFR40.41620733
135CDK190.41542091
136MAPK10.39571880
137SGK30.38871338
138CSNK1G10.36559291
139GSK3B0.35127516
140MAPK100.34641788
141INSR0.33082688
142AURKB0.30942911
143AKT20.30804346
144PRKDC0.30552994
145AKT10.29772306
146WNK10.29331374
147TYK20.28574035

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.47962874
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.68408398
3Staphylococcus aureus infection_Homo sapiens_hsa051502.66629734
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43142042
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.40907821
6One carbon pool by folate_Homo sapiens_hsa006702.28383998
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.21710481
8Arginine biosynthesis_Homo sapiens_hsa002202.21565294
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.17408643
10Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.99209821
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.97978467
12Complement and coagulation cascades_Homo sapiens_hsa046101.96062121
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86757675
14Lysine degradation_Homo sapiens_hsa003101.86275810
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.79540532
16Selenocompound metabolism_Homo sapiens_hsa004501.78050524
17Mismatch repair_Homo sapiens_hsa034301.74111566
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73837884
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73295983
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.71309722
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69081854
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66823096
23Chemical carcinogenesis_Homo sapiens_hsa052041.60951938
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.59914763
25Basal cell carcinoma_Homo sapiens_hsa052171.58893243
26Spliceosome_Homo sapiens_hsa030401.55554465
27Biosynthesis of amino acids_Homo sapiens_hsa012301.55373036
28Notch signaling pathway_Homo sapiens_hsa043301.55142886
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.54458988
30Tryptophan metabolism_Homo sapiens_hsa003801.53093677
31Butanoate metabolism_Homo sapiens_hsa006501.48837440
32DNA replication_Homo sapiens_hsa030301.43343300
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42535020
34Axon guidance_Homo sapiens_hsa043601.41937405
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41705455
36RNA transport_Homo sapiens_hsa030131.35433714
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33522149
38Nicotine addiction_Homo sapiens_hsa050331.33467634
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.32807496
40Retinol metabolism_Homo sapiens_hsa008301.31631833
41Prion diseases_Homo sapiens_hsa050201.30365047
42Other glycan degradation_Homo sapiens_hsa005111.30239241
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27379626
44Basal transcription factors_Homo sapiens_hsa030221.26590499
45Protein export_Homo sapiens_hsa030601.22588233
46Fatty acid degradation_Homo sapiens_hsa000711.16545654
47Hippo signaling pathway_Homo sapiens_hsa043901.15430751
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.14475302
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.06577746
50Melanogenesis_Homo sapiens_hsa049161.05627751
51Fatty acid metabolism_Homo sapiens_hsa012121.04914605
52mRNA surveillance pathway_Homo sapiens_hsa030151.03840052
53beta-Alanine metabolism_Homo sapiens_hsa004101.01279691
54Arginine and proline metabolism_Homo sapiens_hsa003301.01045502
55Hedgehog signaling pathway_Homo sapiens_hsa043401.00659109
56Oocyte meiosis_Homo sapiens_hsa041141.00369304
57Peroxisome_Homo sapiens_hsa041460.98496665
58Propanoate metabolism_Homo sapiens_hsa006400.97970550
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97648982
60Bile secretion_Homo sapiens_hsa049760.95245924
61Glutathione metabolism_Homo sapiens_hsa004800.92964616
62Tyrosine metabolism_Homo sapiens_hsa003500.91556112
63Base excision repair_Homo sapiens_hsa034100.90614137
64TGF-beta signaling pathway_Homo sapiens_hsa043500.90016716
65Histidine metabolism_Homo sapiens_hsa003400.87622155
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85046465
67Carbon metabolism_Homo sapiens_hsa012000.82217834
68PPAR signaling pathway_Homo sapiens_hsa033200.81145199
69Cell cycle_Homo sapiens_hsa041100.81132281
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80587809
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80068626
72Vitamin B6 metabolism_Homo sapiens_hsa007500.79570164
73GABAergic synapse_Homo sapiens_hsa047270.79536657
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78998756
75Glutamatergic synapse_Homo sapiens_hsa047240.75796325
76Melanoma_Homo sapiens_hsa052180.73699644
77Caffeine metabolism_Homo sapiens_hsa002320.73271413
78Cocaine addiction_Homo sapiens_hsa050300.72998298
79Ether lipid metabolism_Homo sapiens_hsa005650.71773955
80p53 signaling pathway_Homo sapiens_hsa041150.70447453
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68368940
82Adherens junction_Homo sapiens_hsa045200.68286632
83ABC transporters_Homo sapiens_hsa020100.66383598
84Fatty acid elongation_Homo sapiens_hsa000620.65674561
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64338679
86Phenylalanine metabolism_Homo sapiens_hsa003600.64256025
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60764805
88ECM-receptor interaction_Homo sapiens_hsa045120.60713832
89Folate biosynthesis_Homo sapiens_hsa007900.60153722
90Starch and sucrose metabolism_Homo sapiens_hsa005000.58486133
91Pyruvate metabolism_Homo sapiens_hsa006200.56083794
92Steroid biosynthesis_Homo sapiens_hsa001000.55727603
93Nucleotide excision repair_Homo sapiens_hsa034200.55414713
94Vitamin digestion and absorption_Homo sapiens_hsa049770.54164540
95Endometrial cancer_Homo sapiens_hsa052130.53015341
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52306164
97Colorectal cancer_Homo sapiens_hsa052100.51710832
98Glioma_Homo sapiens_hsa052140.51185685
99Thyroid hormone synthesis_Homo sapiens_hsa049180.50954675
100MicroRNAs in cancer_Homo sapiens_hsa052060.50716935
101Circadian entrainment_Homo sapiens_hsa047130.50707119
102Gap junction_Homo sapiens_hsa045400.50507591
103Lysosome_Homo sapiens_hsa041420.50264788
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48439105
105Amphetamine addiction_Homo sapiens_hsa050310.48269116
106Taste transduction_Homo sapiens_hsa047420.46140051
107Wnt signaling pathway_Homo sapiens_hsa043100.45783202
108RNA degradation_Homo sapiens_hsa030180.43922530
109Rap1 signaling pathway_Homo sapiens_hsa040150.43836706
110Dopaminergic synapse_Homo sapiens_hsa047280.43598275
111Non-homologous end-joining_Homo sapiens_hsa034500.41894768
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41873026
113RNA polymerase_Homo sapiens_hsa030200.40771685
114Tight junction_Homo sapiens_hsa045300.40703161
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.39013375
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38765250
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.38623437
118ErbB signaling pathway_Homo sapiens_hsa040120.37540602
119Renal cell carcinoma_Homo sapiens_hsa052110.37312140
120Fanconi anemia pathway_Homo sapiens_hsa034600.36456345
121Homologous recombination_Homo sapiens_hsa034400.34842797
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33823557
123Fat digestion and absorption_Homo sapiens_hsa049750.32579076
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32241232
125Pathways in cancer_Homo sapiens_hsa052000.29696787
126Fructose and mannose metabolism_Homo sapiens_hsa000510.29591347
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27467651
128Pyrimidine metabolism_Homo sapiens_hsa002400.27000372
129Fatty acid biosynthesis_Homo sapiens_hsa000610.23698882
130Prostate cancer_Homo sapiens_hsa052150.21712855
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.20946442

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