SACS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12.8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that 'the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins' (Parfitt et al., PubMed: 19208651). A pseudogene associated with this gene is located on chromosome 11. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.11709997
2nuclear pore organization (GO:0006999)5.39406266
3locomotory exploration behavior (GO:0035641)4.98524297
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.90380903
5synaptic vesicle maturation (GO:0016188)4.83065304
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.42468880
7pore complex assembly (GO:0046931)4.30858455
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.27077275
9mitotic sister chromatid cohesion (GO:0007064)4.23601014
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.14939031
11vocalization behavior (GO:0071625)4.10581240
12glutamate secretion (GO:0014047)4.06402751
13regulation of glutamate receptor signaling pathway (GO:1900449)4.04765241
14synaptic vesicle exocytosis (GO:0016079)4.01220222
15cerebellar Purkinje cell differentiation (GO:0021702)3.99857225
16synaptic vesicle docking involved in exocytosis (GO:0016081)3.95459220
17regulation of synaptic vesicle exocytosis (GO:2000300)3.94519129
18neuronal action potential propagation (GO:0019227)3.91806560
19layer formation in cerebral cortex (GO:0021819)3.89246184
20exploration behavior (GO:0035640)3.81042468
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.79659382
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76775469
23protein localization to synapse (GO:0035418)3.69962606
24establishment of nucleus localization (GO:0040023)3.66699538
25paraxial mesoderm development (GO:0048339)3.65508255
26regulation of synapse structural plasticity (GO:0051823)3.62394947
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.50874524
28glutamate receptor signaling pathway (GO:0007215)3.47852932
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47688494
30negative regulation of DNA repair (GO:0045738)3.46962541
31positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.41845703
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.40339776
33neuron cell-cell adhesion (GO:0007158)3.39288558
34regulation of neuronal synaptic plasticity (GO:0048168)3.38865676
35DNA unwinding involved in DNA replication (GO:0006268)3.37587328
36neurotransmitter secretion (GO:0007269)3.36789530
37regulation of synaptic vesicle transport (GO:1902803)3.35942909
38synaptic transmission, glutamatergic (GO:0035249)3.35733677
39regulation of dendritic spine morphogenesis (GO:0061001)3.32799323
40cellular potassium ion homeostasis (GO:0030007)3.31053574
41mitotic chromosome condensation (GO:0007076)3.30497531
42membrane depolarization during action potential (GO:0086010)3.30058356
43neuron-neuron synaptic transmission (GO:0007270)3.26310541
44dendritic spine morphogenesis (GO:0060997)3.25810651
45sodium ion export (GO:0071436)3.25268230
46cell communication by electrical coupling (GO:0010644)3.23683500
47activation of protein kinase A activity (GO:0034199)3.20958069
48vesicle transport along microtubule (GO:0047496)3.20287491
49axonal fasciculation (GO:0007413)3.19641325
50dendrite morphogenesis (GO:0048813)3.19485945
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18839109
52regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.17376955
53regulation of RNA export from nucleus (GO:0046831)3.14886594
54long-term memory (GO:0007616)3.11925886
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07938595
56regulation of postsynaptic membrane potential (GO:0060078)3.07353696
57sister chromatid segregation (GO:0000819)3.07095480
58regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.05069341
59proline transport (GO:0015824)3.04920783
60positive regulation of synapse maturation (GO:0090129)3.04383881
61neuron recognition (GO:0008038)3.04271024
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.04057243
63neuromuscular process controlling balance (GO:0050885)3.02084416
64positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.00462632
65regulation of mitotic spindle organization (GO:0060236)2.98742249
66plasma membrane repair (GO:0001778)2.98199736
67mitotic cytokinesis (GO:0000281)2.96737450
68organelle transport along microtubule (GO:0072384)2.92628148
69regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.89405868
70regulation of synaptic plasticity (GO:0048167)2.88772431
71positive regulation of fibroblast migration (GO:0010763)2.88439518
72regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88358915
73neurotransmitter-gated ion channel clustering (GO:0072578)2.86060426
74cell migration in hindbrain (GO:0021535)2.85967056
75gamma-aminobutyric acid transport (GO:0015812)2.84909399
76innervation (GO:0060384)2.84887610
77cytoskeleton-dependent cytokinesis (GO:0061640)2.83610957
78NLS-bearing protein import into nucleus (GO:0006607)2.83195204
79regulation of dendritic spine development (GO:0060998)2.82586609
80regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.81620093
81membrane depolarization (GO:0051899)2.81512179
82nerve growth factor signaling pathway (GO:0038180)2.81402605
83G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.80949411
84regulation of ARF protein signal transduction (GO:0032012)2.80346041
85G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.80099540
86protein localization to chromosome, centromeric region (GO:0071459)2.78122824
87cytoplasmic mRNA processing body assembly (GO:0033962)2.77698387
88transmission of nerve impulse (GO:0019226)2.77418947
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.76050555
90positive regulation of dendritic spine morphogenesis (GO:0061003)2.76000662
91synaptic vesicle endocytosis (GO:0048488)2.74830395
92generation of neurons (GO:0048699)2.74820159
93positive regulation of potassium ion transmembrane transport (GO:1901381)2.74352889
94pre-miRNA processing (GO:0031054)2.74348829
95gamma-aminobutyric acid signaling pathway (GO:0007214)2.74042602
96regulation of centriole replication (GO:0046599)2.72941945
97mitotic sister chromatid segregation (GO:0000070)2.71777963
98long-term synaptic potentiation (GO:0060291)2.71646382
99regulation of synaptic transmission, glutamatergic (GO:0051966)2.71495319
100behavioral fear response (GO:0001662)2.70726000
101behavioral defense response (GO:0002209)2.70726000
102regulation of calcium ion transmembrane transport (GO:1903169)2.69766285
103regulation of calcium ion transmembrane transporter activity (GO:1901019)2.69766285
104mitotic metaphase plate congression (GO:0007080)2.68792764
105positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.67082165
106prepulse inhibition (GO:0060134)2.66951820
107regulation of nucleobase-containing compound transport (GO:0032239)2.66935923
108regulation of NFAT protein import into nucleus (GO:0051532)2.66099220
109hippo signaling (GO:0035329)2.66049392
110protein localization to kinetochore (GO:0034501)2.65989324
111positive regulation of membrane potential (GO:0045838)2.65753771
112metaphase plate congression (GO:0051310)2.65643988
113regulation of spindle organization (GO:0090224)2.63066718
114regulation of neurotransmitter secretion (GO:0046928)2.62854334
115response to histamine (GO:0034776)2.62543356
116clathrin coat assembly (GO:0048268)2.61105278
117neuromuscular process (GO:0050905)2.59765630
118nucleus localization (GO:0051647)2.59425417
119DNA duplex unwinding (GO:0032508)2.59154283
120regulation of cell communication by electrical coupling (GO:0010649)2.59093128
121potassium ion import (GO:0010107)2.58343276
122presynaptic membrane assembly (GO:0097105)2.57552088
123central nervous system projection neuron axonogenesis (GO:0021952)2.57465954
124morphogenesis of an epithelial sheet (GO:0002011)2.57290816
125negative regulation of cell killing (GO:0031342)2.57037613
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.57037613
127double-strand break repair via nonhomologous end joining (GO:0006303)2.56792614
128non-recombinational repair (GO:0000726)2.56792614
129lymphangiogenesis (GO:0001946)2.56713497
130cell migration involved in sprouting angiogenesis (GO:0002042)2.55279865
131chondrocyte proliferation (GO:0035988)2.52882796
132neurotransmitter transport (GO:0006836)2.52543838
133establishment of chromosome localization (GO:0051303)2.52416418
134axon extension (GO:0048675)2.51632334
135mitotic spindle organization (GO:0007052)2.51494766
136regulation of potassium ion transmembrane transporter activity (GO:1901016)2.51385908
137artery development (GO:0060840)2.51204138
138DNA geometric change (GO:0032392)2.51099296
139regulation of voltage-gated calcium channel activity (GO:1901385)2.50988928
140regulation of DNA endoreduplication (GO:0032875)2.50452662
141retina vasculature morphogenesis in camera-type eye (GO:0061299)2.50046863
142positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.49956093
143negative regulation of fibroblast apoptotic process (GO:2000270)2.48815763
144regulation of centrosome duplication (GO:0010824)2.43806646
145regulation of transforming growth factor beta2 production (GO:0032909)2.42821407
146collagen fibril organization (GO:0030199)2.40823997
147regulation of centrosome cycle (GO:0046605)2.40240248
148coronary vasculature morphogenesis (GO:0060977)2.40115732
149presynaptic membrane organization (GO:0097090)2.36751765
150establishment of spindle localization (GO:0051293)2.36691412
151regulation of sister chromatid cohesion (GO:0007063)2.35871983
152monoubiquitinated protein deubiquitination (GO:0035520)2.33337361
153spindle checkpoint (GO:0031577)2.31149520
154cell adhesion mediated by integrin (GO:0033627)2.31136637
155nuclear envelope disassembly (GO:0051081)2.30867946
156membrane disassembly (GO:0030397)2.30867946
157membrane assembly (GO:0071709)2.27958215
158establishment of spindle orientation (GO:0051294)2.27881127
159interkinetic nuclear migration (GO:0022027)2.27663872
160notochord development (GO:0030903)2.24941137
161mitotic nuclear envelope disassembly (GO:0007077)2.24332595
162neuron projection extension (GO:1990138)2.24104842
163regulation of mitotic metaphase/anaphase transition (GO:0030071)2.21988492
164regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.21988492
165centrosome duplication (GO:0051298)2.21939236
166regulation of mitotic sister chromatid separation (GO:0010965)2.21181872
167regulation of mitotic sister chromatid segregation (GO:0033047)2.21181872
168regulation of sister chromatid segregation (GO:0033045)2.21181872
169regulation of chromosome segregation (GO:0051983)2.20669086
170regulation of Rac protein signal transduction (GO:0035020)2.19319876
171positive regulation of mitotic sister chromatid separation (GO:1901970)2.19086462
172positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.19086462
173positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.19086462
174positive regulation of chromosome segregation (GO:0051984)2.18867109
175regulation of axon extension involved in axon guidance (GO:0048841)2.18846570
176gastrulation with mouth forming second (GO:0001702)2.18468167
177cardiac cell development (GO:0055006)2.17813888
178mesenchymal-epithelial cell signaling (GO:0060638)2.17325824
179kidney mesenchyme development (GO:0072074)2.17145945
180positive regulation of cell cycle checkpoint (GO:1901978)2.17089511
181G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.16337877
182cardiac muscle cell development (GO:0055013)2.15191694
183mitotic spindle checkpoint (GO:0071174)2.14865600
184hemidesmosome assembly (GO:0031581)2.14729505
185spindle organization (GO:0007051)2.12718526
186negative regulation of chromosome segregation (GO:0051985)2.11907211
187negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.08703054
188negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.08703054
189negative regulation of mitotic sister chromatid segregation (GO:0033048)2.08703054
190negative regulation of mitotic sister chromatid separation (GO:2000816)2.08703054
191negative regulation of sister chromatid segregation (GO:0033046)2.08703054
192somitogenesis (GO:0001756)2.08489096
193peptidyl-lysine dimethylation (GO:0018027)2.08112690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.63643197
2E2F7_22180533_ChIP-Seq_HELA_Human5.59848077
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.85919665
4GBX2_23144817_ChIP-Seq_PC3_Human3.40684433
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.76074064
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.67860187
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64093515
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.57342479
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.57229698
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47413301
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44998158
12DROSHA_22980978_ChIP-Seq_HELA_Human2.43725333
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41351462
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.20919249
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20778008
16REST_21632747_ChIP-Seq_MESCs_Mouse2.17006017
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.14252892
18AR_21572438_ChIP-Seq_LNCaP_Human2.14071888
19AR_21909140_ChIP-Seq_LNCAP_Human2.11302317
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10873815
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10873815
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05076495
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96832630
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95828199
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92440487
26SMAD4_21799915_ChIP-Seq_A2780_Human1.84513357
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82368995
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82030841
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81986754
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.80102904
31TP53_16413492_ChIP-PET_HCT116_Human1.78254817
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.77785039
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.76580675
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75981625
35TAF15_26573619_Chip-Seq_HEK293_Human1.74015222
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73627464
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.73061639
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71976454
39BRD4_25478319_ChIP-Seq_HGPS_Human1.70282796
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65263250
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.64828794
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62948861
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62574711
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.60862393
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.60254032
46ZNF274_21170338_ChIP-Seq_K562_Hela1.58702446
47SOX9_26525672_Chip-Seq_HEART_Mouse1.56869906
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56680930
49STAT3_23295773_ChIP-Seq_U87_Human1.54124428
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.52929923
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51856424
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.50543199
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44855215
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43833088
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.42738539
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42235671
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40578962
58AR_19668381_ChIP-Seq_PC3_Human1.38500212
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38405003
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37697037
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37557835
62P300_19829295_ChIP-Seq_ESCs_Human1.37401758
63TP53_18474530_ChIP-ChIP_U2OS_Human1.37383503
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35908926
65* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.35283695
66TCF4_23295773_ChIP-Seq_U87_Human1.34830994
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34827041
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33929445
69YAP1_20516196_ChIP-Seq_MESCs_Mouse1.33668510
70* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32640446
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.32578044
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31008975
73FUS_26573619_Chip-Seq_HEK293_Human1.30661486
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29531191
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29531191
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.28630193
77IGF1R_20145208_ChIP-Seq_DFB_Human1.27218333
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25891295
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25648677
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25526099
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25338914
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24871113
83* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23824590
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23573144
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21730869
86CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21327820
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20399091
88AR_25329375_ChIP-Seq_VCAP_Human1.19979873
89TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19125562
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19058170
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18988351
92TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18726346
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.17999853
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17717977
95ISL1_27105846_Chip-Seq_CPCs_Mouse1.17472098
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16800571
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15463796
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15139212
99AHR_22903824_ChIP-Seq_MCF-7_Human1.14818250
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14591860
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14047956
102TRIM28_21343339_ChIP-Seq_HEK293_Human1.13166368
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13024977
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11566939
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08517242
106KDM2B_26808549_Chip-Seq_K562_Human1.08114398
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07712820
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07229196
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.06656001
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.06256308
111CJUN_26792858_Chip-Seq_BT549_Human1.04584214
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.04558200
113TCF4_18268006_ChIP-ChIP_LS174T_Human1.03056557
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.02799978
115* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02779550
116* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02503376
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01596250
118ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01505126
119EWS_26573619_Chip-Seq_HEK293_Human1.01280564
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00919953
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00919953
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00365943
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99922858
124EP300_21415370_ChIP-Seq_HL-1_Mouse0.99460546
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97604676
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97538979
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96729118
128FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96384008
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.96350914
130RING1B_27294783_Chip-Seq_NPCs_Mouse0.96286614
131* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96036053
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96023599
133KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95816848
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.95758101
135TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94925653
136* RUNX2_22187159_ChIP-Seq_PCA_Human0.94667133
137* KDM2B_26808549_Chip-Seq_REH_Human0.94621397
138P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94165407
139BCAT_22108803_ChIP-Seq_LS180_Human0.94060841
140GF1B_26923725_Chip-Seq_HPCs_Mouse0.93645648
141HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93644459
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93566922
143JUN_21703547_ChIP-Seq_K562_Human0.93056571
144CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91939135
145KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91751487
146LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91560320
147ELK1_19687146_ChIP-ChIP_HELA_Human0.88636829
148PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88316268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.99617366
2MP0003880_abnormal_central_pattern4.02328277
3MP0003635_abnormal_synaptic_transmissio3.66832886
4MP0004270_analgesia3.40668490
5MP0008057_abnormal_DNA_replication3.03959848
6MP0009046_muscle_twitch2.93482893
7MP0008438_abnormal_cutaneous_collagen2.92146526
8MP0002063_abnormal_learning/memory/cond2.89038749
9MP0009745_abnormal_behavioral_response2.83034223
10MP0000569_abnormal_digit_pigmentation2.68363999
11MP0001968_abnormal_touch/_nociception2.65906494
12MP0003705_abnormal_hypodermis_morpholog2.63567273
13MP0002064_seizures2.55297687
14MP0003787_abnormal_imprinting2.41866184
15MP0005423_abnormal_somatic_nervous2.33422845
16MP0002572_abnormal_emotion/affect_behav2.27628136
17MP0002735_abnormal_chemical_nociception2.25123428
18MP0002734_abnormal_mechanical_nocicepti2.18831369
19MP0001486_abnormal_startle_reflex2.15165969
20MP0004272_abnormal_basement_membrane2.11396235
21MP0002272_abnormal_nervous_system2.08603460
22MP0010094_abnormal_chromosome_stability1.97505859
23MP0000751_myopathy1.95274404
24MP0004811_abnormal_neuron_physiology1.86874442
25MP0008569_lethality_at_weaning1.85450398
26MP0002736_abnormal_nociception_after1.84794023
27MP0002067_abnormal_sensory_capabilities1.83145464
28MP0000733_abnormal_muscle_development1.79673751
29MP0003941_abnormal_skin_development1.77956599
30MP0000778_abnormal_nervous_system1.77502641
31MP0003385_abnormal_body_wall1.76723482
32MP0003950_abnormal_plasma_membrane1.76423952
33MP0002184_abnormal_innervation1.76084027
34MP0009780_abnormal_chondrocyte_physiolo1.75163713
35MP0001440_abnormal_grooming_behavior1.74089321
36MP0000428_abnormal_craniofacial_morphol1.70504777
37MP0004215_abnormal_myocardial_fiber1.67433553
38MP0005386_behavior/neurological_phenoty1.67148192
39MP0004924_abnormal_behavior1.67148192
40MP0003937_abnormal_limbs/digits/tail_de1.66854725
41MP0002822_catalepsy1.66382932
42MP0002733_abnormal_thermal_nociception1.64699365
43MP0003111_abnormal_nucleus_morphology1.64384379
44MP0002009_preneoplasia1.61463403
45MP0010368_abnormal_lymphatic_system1.61439950
46MP0001501_abnormal_sleep_pattern1.58916095
47MP0002697_abnormal_eye_size1.54847743
48MP0001970_abnormal_pain_threshold1.54775214
49MP0003077_abnormal_cell_cycle1.51070690
50MP0000537_abnormal_urethra_morphology1.50665903
51MP0004145_abnormal_muscle_electrophysio1.49659477
52MP0003122_maternal_imprinting1.47943457
53MP0003935_abnormal_craniofacial_develop1.47801607
54MP0002877_abnormal_melanocyte_morpholog1.46683548
55MP0000534_abnormal_ureter_morphology1.44850001
56MP0000955_abnormal_spinal_cord1.43479506
57MP0004510_myositis1.42280470
58MP0004858_abnormal_nervous_system1.42193371
59MP0009250_abnormal_appendicular_skeleto1.42143179
60MP0005257_abnormal_intraocular_pressure1.41859078
61MP0005623_abnormal_meninges_morphology1.41739927
62MP0003890_abnormal_embryonic-extraembry1.40463278
63MP0009697_abnormal_copulation1.38110636
64MP0003121_genomic_imprinting1.38031671
65MP0006276_abnormal_autonomic_nervous1.34937205
66MP0005275_abnormal_skin_tensile1.34667550
67MP0002557_abnormal_social/conspecific_i1.34329684
68MP0005503_abnormal_tendon_morphology1.33735042
69MP0004233_abnormal_muscle_weight1.32643567
70MP0009053_abnormal_anal_canal1.32000172
71MP0003755_abnormal_palate_morphology1.31847064
72MP0002084_abnormal_developmental_patter1.28811740
73MP0001879_abnormal_lymphatic_vessel1.26653354
74MP0002909_abnormal_adrenal_gland1.26040690
75MP0002882_abnormal_neuron_morphology1.23862525
76MP0008932_abnormal_embryonic_tissue1.23831689
77MP0004957_abnormal_blastocyst_morpholog1.22222481
78MP0001299_abnormal_eye_distance/1.21841292
79MP0004084_abnormal_cardiac_muscle1.20647065
80MP0004484_altered_response_of1.19759755
81MP0010030_abnormal_orbit_morphology1.18825141
82MP0005171_absent_coat_pigmentation1.18107512
83MP0002066_abnormal_motor_capabilities/c1.17613253
84MP0002233_abnormal_nose_morphology1.17403073
85MP0009384_cardiac_valve_regurgitation1.16134413
86MP0005248_abnormal_Harderian_gland1.15062259
87MP0002085_abnormal_embryonic_tissue1.14864270
88MP0004197_abnormal_fetal_growth/weight/1.13888736
89MP0003633_abnormal_nervous_system1.13758712
90MP0003566_abnormal_cell_adhesion1.13693365
91MP0003942_abnormal_urinary_system1.13141808
92MP0002152_abnormal_brain_morphology1.12255317
93MP0000432_abnormal_head_morphology1.11383561
94MP0008007_abnormal_cellular_replicative1.10562189
95MP0008877_abnormal_DNA_methylation1.10093386
96MP0001293_anophthalmia1.10079860
97MP0005380_embryogenesis_phenotype1.09990518
98MP0001672_abnormal_embryogenesis/_devel1.09990518
99MP0001286_abnormal_eye_development1.09374512
100MP0003984_embryonic_growth_retardation1.09010396
101MP0004085_abnormal_heartbeat1.07181441
102MP0003045_fibrosis1.07013829
103MP0002092_abnormal_eye_morphology1.06448119
104MP0002114_abnormal_axial_skeleton1.04452498
105MP0002081_perinatal_lethality1.04029338
106MP0002088_abnormal_embryonic_growth/wei1.03900940
107MP0002108_abnormal_muscle_morphology1.02598399
108MP0003631_nervous_system_phenotype1.01561835
109MP0000762_abnormal_tongue_morphology1.00635097
110MP0003329_amyloid_beta_deposits1.00315049
111MP0001730_embryonic_growth_arrest0.99170307
112MP0003137_abnormal_impulse_conducting0.97835721
113MP0000350_abnormal_cell_proliferation0.97200062
114MP0003123_paternal_imprinting0.96900928
115MP0009703_decreased_birth_body0.96592213
116MP0010307_abnormal_tumor_latency0.96105608
117MP0000747_muscle_weakness0.95830757
118MP0004134_abnormal_chest_morphology0.95320032
119MP0001958_emphysema0.95252670
120MP0008961_abnormal_basal_metabolism0.95059134
121MP0001915_intracranial_hemorrhage0.94654204
122MP0000767_abnormal_smooth_muscle0.94554008
123MP0002177_abnormal_outer_ear0.94505508
124MP0003879_abnormal_hair_cell0.94365663
125MP0001188_hyperpigmentation0.91628507
126MP0005409_darkened_coat_color0.91415744
127MP0000749_muscle_degeneration0.90846171
128MP0000049_abnormal_middle_ear0.89337214
129MP0004087_abnormal_muscle_fiber0.88860191
130MP0004036_abnormal_muscle_relaxation0.88393452
131MP0003279_aneurysm0.88331740
132MP0001346_abnormal_lacrimal_gland0.87555638
133MP0005187_abnormal_penis_morphology0.86450536
134MP0002086_abnormal_extraembryonic_tissu0.86282260
135MP0003221_abnormal_cardiomyocyte_apopto0.85957743
136MP0002837_dystrophic_cardiac_calcinosis0.85339437
137MP0005646_abnormal_pituitary_gland0.84784622
138MP0009672_abnormal_birth_weight0.84163965
139MP0001697_abnormal_embryo_size0.83794762
140MP0003115_abnormal_respiratory_system0.83782181
141MP0002751_abnormal_autonomic_nervous0.83054357
142MP0003091_abnormal_cell_migration0.82979371
143MP0003861_abnormal_nervous_system0.82555048
144MP0001984_abnormal_olfaction0.81664012
145MP0002234_abnormal_pharynx_morphology0.81336966
146MP0002116_abnormal_craniofacial_bone0.80948471
147MP0003632_abnormal_nervous_system0.79900026
148MP0004142_abnormal_muscle_tone0.79282518
149MP0001348_abnormal_lacrimal_gland0.78246603
150MP0005620_abnormal_muscle_contractility0.75669424
151MP0004885_abnormal_endolymph0.74329710
152MP0001177_atelectasis0.73375826
153MP0008770_decreased_survivor_rate0.72642823
154MP0000759_abnormal_skeletal_muscle0.72431253
155MP0002106_abnormal_muscle_physiology0.71885736
156MP0008874_decreased_physiological_sensi0.70706060
157MP0001502_abnormal_circadian_rhythm0.69518194
158MP0001529_abnormal_vocalization0.69126275
159MP0010769_abnormal_survival0.67959794
160MP0001943_abnormal_respiration0.67076932
161MP0002972_abnormal_cardiac_muscle0.66972271
162MP0002269_muscular_atrophy0.64933106
163MP0002082_postnatal_lethality0.64439080
164MP0010770_preweaning_lethality0.64439080
165MP0010768_mortality/aging0.64142882
166MP0008775_abnormal_heart_ventricle0.64060203
167MP0003300_gastrointestinal_ulcer0.63344652
168MP0002229_neurodegeneration0.63338851
169MP0005369_muscle_phenotype0.62844619
170MP0005076_abnormal_cell_differentiation0.62545269
171MP0010352_gastrointestinal_tract_polyps0.62197644
172MP0003646_muscle_fatigue0.61808093
173MP0000013_abnormal_adipose_tissue0.61722927
174MP0003634_abnormal_glial_cell0.60938399
175MP0004130_abnormal_muscle_cell0.60753215

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.37663966
2Focal seizures (HP:0007359)4.54369669
3Myokymia (HP:0002411)4.42823605
4Febrile seizures (HP:0002373)3.78523513
5Progressive cerebellar ataxia (HP:0002073)3.71418415
6Atonic seizures (HP:0010819)3.69996069
7Action tremor (HP:0002345)3.45535432
8Visual hallucinations (HP:0002367)3.41934188
9Epileptic encephalopathy (HP:0200134)3.35699633
10Dysmetric saccades (HP:0000641)3.21186713
11Absence seizures (HP:0002121)3.13192942
12Gaze-evoked nystagmus (HP:0000640)3.09562476
13Urinary bladder sphincter dysfunction (HP:0002839)3.07357625
14Genetic anticipation (HP:0003743)3.02194502
15Broad-based gait (HP:0002136)3.00090245
16Premature rupture of membranes (HP:0001788)2.99764012
17Termporal pattern (HP:0011008)2.97134729
18Insidious onset (HP:0003587)2.97134729
19Lower limb amyotrophy (HP:0007210)2.87848833
20Papilledema (HP:0001085)2.80798746
21Dialeptic seizures (HP:0011146)2.76015112
22Poor eye contact (HP:0000817)2.63834453
23Generalized tonic-clonic seizures (HP:0002069)2.58790225
24Dysdiadochokinesis (HP:0002075)2.58073983
25Aortic dissection (HP:0002647)2.54725008
26Pointed chin (HP:0000307)2.54079390
27Drooling (HP:0002307)2.53001236
28Excessive salivation (HP:0003781)2.53001236
29* Truncal ataxia (HP:0002078)2.52641878
30Abnormality of the lower motor neuron (HP:0002366)2.51109106
31Macroorchidism (HP:0000053)2.50906264
32Protrusio acetabuli (HP:0003179)2.48291385
33Arterial tortuosity (HP:0005116)2.46491787
34Abnormal social behavior (HP:0012433)2.43366363
35Impaired social interactions (HP:0000735)2.43366363
36Vertebral arch anomaly (HP:0008438)2.39812353
37Overgrowth (HP:0001548)2.35700152
38* Impaired smooth pursuit (HP:0007772)2.34577614
39Vascular tortuosity (HP:0004948)2.33954389
40* Impaired vibration sensation in the lower limbs (HP:0002166)2.31668135
41* Urinary urgency (HP:0000012)2.30675690
42Depression (HP:0000716)2.30323422
43Inappropriate behavior (HP:0000719)2.29563098
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28484999
45Aortic aneurysm (HP:0004942)2.26435526
46Spinal cord lesions (HP:0100561)2.25185212
47Syringomyelia (HP:0003396)2.25185212
48Ankle clonus (HP:0011448)2.23945161
49Absent frontal sinuses (HP:0002688)2.20544791
50Type 1 muscle fiber predominance (HP:0003803)2.19744086
51Chromsome breakage (HP:0040012)2.19591148
52Calcaneovalgus deformity (HP:0001848)2.18947672
53Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.18817963
54Volvulus (HP:0002580)2.16311032
55Nemaline bodies (HP:0003798)2.15688747
56Cortical dysplasia (HP:0002539)2.15188199
57Abnormality of the calcaneus (HP:0008364)2.14542425
58* Abnormality of ocular smooth pursuit (HP:0000617)2.14463068
59Postural instability (HP:0002172)2.14421681
60Aqueductal stenosis (HP:0002410)2.13027774
61Hemiplegia (HP:0002301)2.09732710
62Distal lower limb amyotrophy (HP:0008944)2.08959760
63Shallow orbits (HP:0000586)2.08399931
64Mitral valve prolapse (HP:0001634)2.06901312
65* Dysmetria (HP:0001310)2.06572575
66Amblyopia (HP:0000646)2.06388520
67Supranuclear gaze palsy (HP:0000605)2.05102298
68Resting tremor (HP:0002322)2.04390723
69Muscle fiber inclusion bodies (HP:0100299)2.03537636
70Atrophic scars (HP:0001075)2.02519041
71Increased nuchal translucency (HP:0010880)2.01946676
72Obsessive-compulsive behavior (HP:0000722)2.01477605
73Spastic gait (HP:0002064)2.00851842
74Stereotypic behavior (HP:0000733)1.99753235
75Diplopia (HP:0000651)1.96320859
76Abnormality of binocular vision (HP:0011514)1.96320859
77Deformed tarsal bones (HP:0008119)1.95137916
78Relative macrocephaly (HP:0004482)1.95100087
79Sudden death (HP:0001699)1.94446377
80Abnormality of the astrocytes (HP:0100707)1.93509973
81Astrocytoma (HP:0009592)1.93509973
82Hyperacusis (HP:0010780)1.93160766
83Bladder diverticulum (HP:0000015)1.91622629
84Ankyloglossia (HP:0010296)1.91540082
85Difficulty running (HP:0009046)1.91536833
86Annular pancreas (HP:0001734)1.90693763
87Prolonged QT interval (HP:0001657)1.90117222
88Abnormality of the corticospinal tract (HP:0002492)1.89790503
89Soft skin (HP:0000977)1.89579673
90Lower limb muscle weakness (HP:0007340)1.88700454
91Limited hip movement (HP:0008800)1.88332146
92Protruding tongue (HP:0010808)1.88275331
93Medulloblastoma (HP:0002885)1.87588148
94Primary atrial arrhythmia (HP:0001692)1.87501798
95Insomnia (HP:0100785)1.87311532
96Atrial fibrillation (HP:0005110)1.86261797
97Amyotrophic lateral sclerosis (HP:0007354)1.85191727
98Abnormality of oral frenula (HP:0000190)1.84566647
99Deep philtrum (HP:0002002)1.84544152
100Progressive inability to walk (HP:0002505)1.82311354
101Cystic hygroma (HP:0000476)1.82285104
102Short chin (HP:0000331)1.81900832
103Ankle contracture (HP:0006466)1.81786498
104Missing ribs (HP:0000921)1.80580642
105Absent speech (HP:0001344)1.80321902
106Open mouth (HP:0000194)1.80286418
107Sacral dimple (HP:0000960)1.79959693
108Ventricular fibrillation (HP:0001663)1.78403271
109Distal arthrogryposis (HP:0005684)1.78301060
110Hyperventilation (HP:0002883)1.76684326
111Hemiparesis (HP:0001269)1.76313664
112Abnormality of the ischium (HP:0003174)1.76204337
113Mild short stature (HP:0003502)1.75326558
114Cutaneous syndactyly (HP:0012725)1.74197126
115Shoulder girdle muscle weakness (HP:0003547)1.74188219
116Rhabdomyosarcoma (HP:0002859)1.73975874
117Cutaneous finger syndactyly (HP:0010554)1.72899776
118Supraventricular tachycardia (HP:0004755)1.72233330
119Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72071315
120Short 4th metacarpal (HP:0010044)1.72071315
121Wide anterior fontanel (HP:0000260)1.71591605
122Heterotopia (HP:0002282)1.71340977
123Bradykinesia (HP:0002067)1.71149155
124Pulmonic stenosis (HP:0001642)1.70809687
125Deeply set eye (HP:0000490)1.70388460
126Hyporeflexia of lower limbs (HP:0002600)1.69150495
127Supraventricular arrhythmia (HP:0005115)1.68865760
128Spinal rigidity (HP:0003306)1.68041451
129Narrow palate (HP:0000189)1.67769251
130Ulnar bowing (HP:0003031)1.67480191
131Renovascular hypertension (HP:0100817)1.67416793
132Papillary thyroid carcinoma (HP:0002895)1.66710682
133Anxiety (HP:0000739)1.66353508
134Epileptiform EEG discharges (HP:0011182)1.65399064
135Long clavicles (HP:0000890)1.65276810
136Intellectual disability, profound (HP:0002187)1.65133302
137Abnormality of the musculature of the pelvis (HP:0001469)1.65082947
138Abnormality of the hip-girdle musculature (HP:0001445)1.65082947
139Embryonal renal neoplasm (HP:0011794)1.64520990
140Pelvic girdle muscle weakness (HP:0003749)1.63638829
141Fetal akinesia sequence (HP:0001989)1.63298141
142Neonatal short-limb short stature (HP:0008921)1.62651762
143Cubitus valgus (HP:0002967)1.62643988
144Skull defect (HP:0001362)1.62452934
145Abnormality of salivation (HP:0100755)1.62439309
146Coronal craniosynostosis (HP:0004440)1.62111745
147Abnormal EKG (HP:0003115)1.61930288
148Abnormality of the left ventricular outflow tract (HP:0011103)1.61548187
149Subaortic stenosis (HP:0001682)1.61548187
150High anterior hairline (HP:0009890)1.61543982
151Nephroblastoma (Wilms tumor) (HP:0002667)1.61375478
152Renal duplication (HP:0000075)1.61220987
153Spondylolisthesis (HP:0003302)1.61061543
154Abnormality of the phalanges of the hallux (HP:0010057)1.60128145
155Bowel diverticulosis (HP:0005222)1.59551389
156Abnormality of the 4th metacarpal (HP:0010012)1.59332031
157Asymmetry of the thorax (HP:0001555)1.59244105
158Bundle branch block (HP:0011710)1.58976738
159Large earlobe (HP:0009748)1.58922115
160Lower limb asymmetry (HP:0100559)1.58888653
161Megalencephaly (HP:0001355)1.58793380
162Wormian bones (HP:0002645)1.58199807
163Subacute progressive viral hepatitis (HP:0006572)1.57024190
164Glioma (HP:0009733)1.56541961
165Broad metatarsal (HP:0001783)1.56016126
166Broad ribs (HP:0000885)1.54382455
167Abnormality of chromosome segregation (HP:0002916)1.53644993
168Limb-girdle muscle weakness (HP:0003325)1.52771918
169Long eyelashes (HP:0000527)1.52762055
170Abnormality of dentin (HP:0010299)1.51256428
171Hepatoblastoma (HP:0002884)1.50380130
172Sandal gap (HP:0001852)1.50185300
173Mesomelia (HP:0003027)1.49629839
174Hypopigmentation of the fundus (HP:0007894)1.49496131
175Arnold-Chiari malformation (HP:0002308)1.49241844
176Flat cornea (HP:0007720)1.48011359
177Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.46879206
178Gastrointestinal carcinoma (HP:0002672)1.46298558
179Malignant gastrointestinal tract tumors (HP:0006749)1.46298558
180Omphalocele (HP:0001539)1.45951431

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.95010279
2EPHA43.40848734
3MAP3K43.21984939
4MAP3K93.07654497
5MARK12.79413068
6MINK12.48363710
7MKNK22.23856076
8NTRK22.21462981
9LATS12.06053190
10MAP2K71.97842723
11PAK61.96823274
12KSR11.87697294
13MAP3K101.85531613
14SRPK11.81970527
15AKT31.76977630
16TSSK61.75573552
17NEK91.69936632
18TTK1.69317918
19CAMKK11.67458720
20MKNK11.66613929
21SIK21.63757847
22TAF11.63019308
23KSR21.62782645
24MAP2K41.56090179
25STK38L1.54583123
26TNIK1.53941500
27ERBB31.52391726
28NTRK11.49392866
29SCYL21.49301821
30PAK21.48223977
31PBK1.43898442
32DAPK21.41643171
33PLK21.40196396
34PNCK1.36363505
35CDK51.34637202
36PRKD31.33552870
37CDK121.32746859
38RIPK11.29505818
39MAPK131.28455266
40RET1.26538770
41CCNB11.24878173
42CAMKK21.23717377
43RIPK41.23377409
44CAMK1G1.22413267
45DMPK1.21672023
46PLK41.20539627
47BCR1.17285710
48WNK11.16942043
49ALK1.16492661
50ICK1.15783667
51DAPK11.15486451
52BRSK21.14197958
53SGK31.14197932
54WEE11.14099475
55SGK21.14065580
56PHKG21.11520636
57PHKG11.11520636
58STK381.10186828
59TTN1.09662506
60BUB11.08078383
61ERBB41.07344960
62MARK21.06279370
63MAP3K71.04390167
64EIF2AK31.03658822
65TYRO31.00807969
66MAP3K121.00450839
67PTK21.00335051
68CHEK20.97839820
69TAOK10.96135967
70CDC70.94326244
71CDK60.93793627
72DDR20.92958754
73SGK10.92851261
74PLK30.92428574
75PRKCH0.92017604
76LATS20.91981232
77MAP3K20.91695972
78FGFR30.88561777
79STK110.88492920
80FES0.87310485
81PLK10.85461400
82ATM0.85369887
83MTOR0.83125274
84LMTK20.82595443
85NEK20.82516716
86RAF10.81404350
87NEK10.81230452
88UHMK10.81204120
89MET0.80662969
90CHEK10.80446195
91PRKCG0.80386381
92CDK180.80194743
93MELK0.79916733
94TRPM70.78525407
95AURKB0.78507520
96STK30.78324299
97CAMK10.76901727
98CDK150.76435029
99CASK0.76261301
100SGK4940.76159288
101SGK2230.76159288
102BRD40.74705852
103CDC42BPA0.72093278
104EPHB20.72072923
105CSNK1A1L0.71692451
106PKN20.71676852
107CDK140.70541043
108MOS0.69855843
109CAMK2A0.69814583
110FGFR20.68517962
111MAPK100.68516874
112OBSCN0.68336088
113MAP3K130.67739512
114CSNK1G10.66528366
115PDGFRA0.66245497
116PDK10.66188003
117CDK80.65821995
118PRPF4B0.64195182
119PAK30.63578382
120ATR0.63058314
121RPS6KA30.63029983
122CAMK40.62185829
123CDK11A0.61807994
124CAMK1D0.61562272
125PTK2B0.60679563
126EEF2K0.60210287
127MAP3K60.59466825
128EIF2AK10.59297966
129TIE10.58053861
130CDK10.57542602
131FGFR10.56926748
132CSNK1G20.54914161
133GRK50.52545381
134PDGFRB0.51379833
135SIK30.50301387
136EPHA30.49796805
137BRSK10.48805471
138CDK20.48207001
139CAMK2B0.47502081
140MAPK80.46534031
141CLK10.46291237
142ROCK20.45529298
143DYRK1A0.45488559
144PRKCB0.45112513
145RPS6KB10.43691624
146FYN0.43623391
147CSNK1E0.42616081
148CDK30.42136939
149GSK3B0.41313884
150ROCK10.41033749
151EIF2AK20.40165074
152TNK20.38056987
153PRKDC0.36994152
154CDK190.35241762
155PDPK10.34777892

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.80760800
2Long-term potentiation_Homo sapiens_hsa047202.51441215
3Non-homologous end-joining_Homo sapiens_hsa034502.30349203
4Circadian entrainment_Homo sapiens_hsa047132.26041904
5Olfactory transduction_Homo sapiens_hsa047402.16939692
6Cell cycle_Homo sapiens_hsa041102.10680065
7Glutamatergic synapse_Homo sapiens_hsa047242.05173376
8Synaptic vesicle cycle_Homo sapiens_hsa047211.99481611
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99301313
10Amphetamine addiction_Homo sapiens_hsa050311.96775416
11Morphine addiction_Homo sapiens_hsa050321.94695084
12GABAergic synapse_Homo sapiens_hsa047271.87752804
13Adherens junction_Homo sapiens_hsa045201.87157951
14Dopaminergic synapse_Homo sapiens_hsa047281.85734693
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78229984
16ECM-receptor interaction_Homo sapiens_hsa045121.75828010
17Salivary secretion_Homo sapiens_hsa049701.74025418
18Hippo signaling pathway_Homo sapiens_hsa043901.73104650
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70803065
20Oxytocin signaling pathway_Homo sapiens_hsa049211.63802867
21Cholinergic synapse_Homo sapiens_hsa047251.63000141
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61098084
23Gastric acid secretion_Homo sapiens_hsa049711.60209214
24Renin secretion_Homo sapiens_hsa049241.54424688
25Insulin secretion_Homo sapiens_hsa049111.48753979
26Long-term depression_Homo sapiens_hsa047301.48160023
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48040191
28Glioma_Homo sapiens_hsa052141.45251535
29Taste transduction_Homo sapiens_hsa047421.42989720
30Small cell lung cancer_Homo sapiens_hsa052221.41115641
31Calcium signaling pathway_Homo sapiens_hsa040201.40649618
32TGF-beta signaling pathway_Homo sapiens_hsa043501.39649592
33GnRH signaling pathway_Homo sapiens_hsa049121.37545568
34Basal cell carcinoma_Homo sapiens_hsa052171.35312004
35mRNA surveillance pathway_Homo sapiens_hsa030151.35284290
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33426569
37Type II diabetes mellitus_Homo sapiens_hsa049301.33026843
38Dorso-ventral axis formation_Homo sapiens_hsa043201.31943994
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30005144
40Dilated cardiomyopathy_Homo sapiens_hsa054141.29665562
41RNA transport_Homo sapiens_hsa030131.29146286
42Hedgehog signaling pathway_Homo sapiens_hsa043401.27634727
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26714298
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26296389
45DNA replication_Homo sapiens_hsa030301.25668240
46Gap junction_Homo sapiens_hsa045401.25347955
47Thyroid cancer_Homo sapiens_hsa052161.24285464
48ErbB signaling pathway_Homo sapiens_hsa040121.23350957
49cAMP signaling pathway_Homo sapiens_hsa040241.23176919
50Lysine degradation_Homo sapiens_hsa003101.23062658
51Estrogen signaling pathway_Homo sapiens_hsa049151.22705555
52Cocaine addiction_Homo sapiens_hsa050301.22580513
53Fanconi anemia pathway_Homo sapiens_hsa034601.22311345
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20145011
55Melanoma_Homo sapiens_hsa052181.19446226
56Serotonergic synapse_Homo sapiens_hsa047261.17838091
57Mismatch repair_Homo sapiens_hsa034301.17499074
58Oocyte meiosis_Homo sapiens_hsa041141.15270808
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14827420
60Axon guidance_Homo sapiens_hsa043601.12869536
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12260265
62mTOR signaling pathway_Homo sapiens_hsa041501.10244842
63Tight junction_Homo sapiens_hsa045301.09476957
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08671767
65Nucleotide excision repair_Homo sapiens_hsa034201.07461276
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06959281
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06854557
68Neurotrophin signaling pathway_Homo sapiens_hsa047221.06352906
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05321480
70Prostate cancer_Homo sapiens_hsa052151.04534589
71Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02707721
72MAPK signaling pathway_Homo sapiens_hsa040101.00589243
73p53 signaling pathway_Homo sapiens_hsa041150.99973579
74Pathways in cancer_Homo sapiens_hsa052000.98827180
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96683014
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.93146049
77Alcoholism_Homo sapiens_hsa050340.92853739
78Melanogenesis_Homo sapiens_hsa049160.92789506
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91383246
80Non-small cell lung cancer_Homo sapiens_hsa052230.89394313
81VEGF signaling pathway_Homo sapiens_hsa043700.88345454
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.86445400
83Spliceosome_Homo sapiens_hsa030400.85442445
84Colorectal cancer_Homo sapiens_hsa052100.82699010
85Endometrial cancer_Homo sapiens_hsa052130.82536044
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82492679
87Choline metabolism in cancer_Homo sapiens_hsa052310.82353057
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81879592
89Viral carcinogenesis_Homo sapiens_hsa052030.79489836
90Circadian rhythm_Homo sapiens_hsa047100.79372772
91Rap1 signaling pathway_Homo sapiens_hsa040150.78605692
92T cell receptor signaling pathway_Homo sapiens_hsa046600.78397833
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77226203
94Bladder cancer_Homo sapiens_hsa052190.76574930
95Cardiac muscle contraction_Homo sapiens_hsa042600.75911114
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75389839
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73983764
98Glucagon signaling pathway_Homo sapiens_hsa049220.73310188
99Renal cell carcinoma_Homo sapiens_hsa052110.73156280
100Chronic myeloid leukemia_Homo sapiens_hsa052200.72468394
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72280217
102Inositol phosphate metabolism_Homo sapiens_hsa005620.70532083
103Ras signaling pathway_Homo sapiens_hsa040140.69015852
104Basal transcription factors_Homo sapiens_hsa030220.68950308
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68318276
106Insulin signaling pathway_Homo sapiens_hsa049100.68112365
107Platelet activation_Homo sapiens_hsa046110.65652031
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64634486
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64611783
110Thyroid hormone synthesis_Homo sapiens_hsa049180.63873532
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63604160
112Systemic lupus erythematosus_Homo sapiens_hsa053220.63325639
113Wnt signaling pathway_Homo sapiens_hsa043100.61953113
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61941869
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61921865
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.58238979
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57725552
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57687467
119Focal adhesion_Homo sapiens_hsa045100.57300976
120Chemokine signaling pathway_Homo sapiens_hsa040620.57201790
121MicroRNAs in cancer_Homo sapiens_hsa052060.56983098
122Proteoglycans in cancer_Homo sapiens_hsa052050.56891421
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.56462345
124Pancreatic secretion_Homo sapiens_hsa049720.56446430
125Pancreatic cancer_Homo sapiens_hsa052120.55817399
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55599813
127Prolactin signaling pathway_Homo sapiens_hsa049170.54754877
128B cell receptor signaling pathway_Homo sapiens_hsa046620.54375131
129Viral myocarditis_Homo sapiens_hsa054160.54183733
130Endocytosis_Homo sapiens_hsa041440.53882543
131HIF-1 signaling pathway_Homo sapiens_hsa040660.52931384
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52620645
133Type I diabetes mellitus_Homo sapiens_hsa049400.52055766
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51217345
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50706225
136FoxO signaling pathway_Homo sapiens_hsa040680.49162283

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