S1PR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replicative senescence (GO:0090399)6.83209696
2hematopoietic stem cell proliferation (GO:0071425)5.63631864
3cell proliferation involved in metanephros development (GO:0072203)5.24922453
4cell migration involved in heart development (GO:0060973)5.22020971
5kidney mesenchyme development (GO:0072074)5.15530711
6metanephric mesenchyme development (GO:0072075)5.11398120
7regulation of somitogenesis (GO:0014807)5.08296826
8positive regulation of prostaglandin secretion (GO:0032308)4.85727068
9protein heterotrimerization (GO:0070208)4.70606879
10endocardial cushion morphogenesis (GO:0003203)4.67280401
11mesenchyme morphogenesis (GO:0072132)4.62411138
12glomerular filtration (GO:0003094)4.48088643
13regulation of prostaglandin secretion (GO:0032306)4.35552224
14vascular endothelial growth factor signaling pathway (GO:0038084)4.33137797
15collagen fibril organization (GO:0030199)4.27678842
16regulation of catenin import into nucleus (GO:0035412)4.22190029
17glomerulus development (GO:0032835)4.16726016
18chondrocyte proliferation (GO:0035988)4.15382281
19detection of calcium ion (GO:0005513)4.12974608
20axon extension involved in axon guidance (GO:0048846)4.08172049
21neuron projection extension involved in neuron projection guidance (GO:1902284)4.08172049
22renal filtration (GO:0097205)4.07738030
23bone trabecula formation (GO:0060346)4.05484808
24epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.05168744
25cell proliferation involved in kidney development (GO:0072111)4.04565025
26negative regulation of catenin import into nucleus (GO:0035414)4.02142287
27glomerular basement membrane development (GO:0032836)3.96467776
28lymph vessel development (GO:0001945)3.95207782
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.94690682
30sequestering of extracellular ligand from receptor (GO:0035581)3.94408289
31planar cell polarity pathway involved in neural tube closure (GO:0090179)3.87663704
32mesenchymal cell development (GO:0014031)3.77275914
33extracellular fibril organization (GO:0043206)3.64466241
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.60082045
35coronary vasculature morphogenesis (GO:0060977)3.58920783
36cellular response to cholesterol (GO:0071397)3.51345051
37cartilage morphogenesis (GO:0060536)3.50547359
38extracellular matrix assembly (GO:0085029)3.48917653
39stem cell development (GO:0048864)3.41984175
40regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.40592436
41negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.39726862
42cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.37347179
43negative regulation of epithelial to mesenchymal transition (GO:0010719)3.35137118
44negative regulation of chondrocyte differentiation (GO:0032331)3.32575411
45hippo signaling (GO:0035329)3.28843468
46glomerular epithelial cell development (GO:0072310)3.24268850
47positive regulation of icosanoid secretion (GO:0032305)3.24165878
48positive regulation of cardiac muscle cell differentiation (GO:2000727)3.24156762
49basement membrane organization (GO:0071711)3.24056141
50regulation of axon extension involved in axon guidance (GO:0048841)3.23623330
51G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.20498170
52regulation of cardiac muscle cell contraction (GO:0086004)3.19888674
53outer ear morphogenesis (GO:0042473)3.18944266
54white fat cell differentiation (GO:0050872)3.18773433
55regulation of heart morphogenesis (GO:2000826)3.17542566
56fibril organization (GO:0097435)3.14714468
57smooth muscle tissue development (GO:0048745)3.13022506
58cardiac myofibril assembly (GO:0055003)3.13007169
59negative regulation of axon extension involved in axon guidance (GO:0048843)3.11308492
60endocardial cushion development (GO:0003197)3.10062776
61mesenchymal cell proliferation (GO:0010463)3.09919651
62embryonic cranial skeleton morphogenesis (GO:0048701)3.09813596
63positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.07699959
64retina vasculature morphogenesis in camera-type eye (GO:0061299)3.06863826
65cardiac epithelial to mesenchymal transition (GO:0060317)3.05813793
66mesenchymal cell differentiation involved in renal system development (GO:2001012)3.05216127
67mesenchymal cell differentiation involved in kidney development (GO:0072161)3.05216127
68cAMP biosynthetic process (GO:0006171)3.02533396
69neural crest cell development (GO:0014032)3.01041282
70dermatan sulfate biosynthetic process (GO:0030208)3.00811825
71positive regulation of fatty acid transport (GO:2000193)3.00005202
72middle ear morphogenesis (GO:0042474)2.98417844
73collagen metabolic process (GO:0032963)2.98410458
74DNA replication-dependent nucleosome assembly (GO:0006335)2.98290807
75DNA replication-dependent nucleosome organization (GO:0034723)2.98290807
76head development (GO:0060322)2.97179437
77mesenchymal-epithelial cell signaling (GO:0060638)2.96780541
78lymphangiogenesis (GO:0001946)2.96473075
79pericardium development (GO:0060039)2.95322335
80regulation of axon guidance (GO:1902667)2.94223648
81negative regulation of fatty acid transport (GO:2000192)2.94206864
82collagen catabolic process (GO:0030574)2.92854552
83heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.91030871
84negative regulation of striated muscle cell apoptotic process (GO:0010664)2.90519714
85plasma membrane repair (GO:0001778)2.89811128
86atrioventricular valve morphogenesis (GO:0003181)2.89517635
87aorta morphogenesis (GO:0035909)2.89275050
88regulation of hippo signaling (GO:0035330)2.89069759
89histamine secretion (GO:0001821)2.88710532
90positive regulation of epithelial to mesenchymal transition (GO:0010718)2.88605905
91positive regulation of endothelial cell apoptotic process (GO:2000353)2.88104460
92positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.88092034
93chondrocyte development (GO:0002063)2.87168053
94cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.86431808
95regulation of cardiac muscle cell differentiation (GO:2000725)2.85991880
96endodermal cell differentiation (GO:0035987)2.85752313
97post-anal tail morphogenesis (GO:0036342)2.83273647
98negative regulation of embryonic development (GO:0045992)2.82127497
99positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81973627
100enteric nervous system development (GO:0048484)2.81783754
101multicellular organismal macromolecule metabolic process (GO:0044259)2.81405278
102Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.80715390
103neuron projection regeneration (GO:0031102)2.80406283
104body morphogenesis (GO:0010171)2.79612239
105negative regulation of cartilage development (GO:0061037)2.76500513
106type B pancreatic cell proliferation (GO:0044342)2.76230801
107cellular response to sterol (GO:0036315)2.75267840
108regulation of epithelial to mesenchymal transition (GO:0010717)2.74944470
109peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.71061680
110glomerular visceral epithelial cell development (GO:0072015)2.70786374
111vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.69880223
112mesenchyme development (GO:0060485)2.69662004
113regulation of actin filament-based movement (GO:1903115)2.69424331
114positive regulation of cardiac muscle hypertrophy (GO:0010613)2.68916958
115positive regulation of muscle hypertrophy (GO:0014742)2.68916958
116organ induction (GO:0001759)2.68720479
117regulation of establishment of planar polarity (GO:0090175)2.68576480
118negative regulation of axon guidance (GO:1902668)2.68111682
119adrenergic receptor signaling pathway (GO:0071875)2.67755660
120positive regulation of fatty acid biosynthetic process (GO:0045723)2.67712076
121multicellular organismal catabolic process (GO:0044243)2.67586199
122glycoprotein biosynthetic process (GO:0009101)2.66876451
123craniofacial suture morphogenesis (GO:0097094)2.66821042
124vasculature development (GO:0001944)2.65725960
125dermatan sulfate metabolic process (GO:0030205)2.65723840
126artery morphogenesis (GO:0048844)2.64680227
127paraxial mesoderm development (GO:0048339)2.64487561
128regulation of non-canonical Wnt signaling pathway (GO:2000050)2.63340106
129negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.63091533
130macroautophagy (GO:0016236)2.62629376
131heart valve morphogenesis (GO:0003179)2.61935061
132positive regulation of fatty acid beta-oxidation (GO:0032000)2.61485897
133ganglion development (GO:0061548)2.60611894
134multicellular organismal metabolic process (GO:0044236)2.59891564
135positive regulation of cartilage development (GO:0061036)2.59819696
136embryonic foregut morphogenesis (GO:0048617)2.59687926
137positive regulation of fatty acid metabolic process (GO:0045923)2.58888163
138epithelial to mesenchymal transition (GO:0001837)2.58706904
139cell adhesion mediated by integrin (GO:0033627)2.58542828
140trabecula formation (GO:0060343)2.58166141
141regulation of cartilage development (GO:0061035)2.57115812
142neuronal action potential (GO:0019228)2.54742277
143positive regulation of cardiac muscle tissue growth (GO:0055023)2.52895612
144cell migration involved in sprouting angiogenesis (GO:0002042)2.52796931
145endothelial cell morphogenesis (GO:0001886)2.50055005
146artery development (GO:0060840)2.47577205
147regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.47266132
148positive regulation of heart rate (GO:0010460)2.46971681
149positive regulation of mesenchymal cell proliferation (GO:0002053)2.46001655
150activation of protein kinase A activity (GO:0034199)2.44639957
151extracellular regulation of signal transduction (GO:1900115)2.42849910
152extracellular negative regulation of signal transduction (GO:1900116)2.42849910
153lung vasculature development (GO:0060426)2.41987706
154regulation of fatty acid transport (GO:2000191)2.41074880
155anterior/posterior axis specification, embryo (GO:0008595)2.40551793
156wound healing, spreading of epidermal cells (GO:0035313)2.39786628
157chondroitin sulfate biosynthetic process (GO:0030206)2.38968459
158keratan sulfate catabolic process (GO:0042340)2.38528748
159axonal fasciculation (GO:0007413)2.38503645
160regulation of cardiac muscle hypertrophy (GO:0010611)2.38237201
161positive regulation of cardiac muscle tissue development (GO:0055025)2.37323910
162heparan sulfate proteoglycan metabolic process (GO:0030201)2.36586538
163positive regulation of fatty acid oxidation (GO:0046321)2.34592613
164regulation of fatty acid beta-oxidation (GO:0031998)2.34350603
165heparin biosynthetic process (GO:0030210)2.32160086
166heparin metabolic process (GO:0030202)2.32160086
167peripheral nervous system axon ensheathment (GO:0032292)2.31528356
168myelination in peripheral nervous system (GO:0022011)2.31528356
169regulation of muscle hypertrophy (GO:0014743)2.31345505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.04590087
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.52435264
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.58854442
4EED_16625203_ChIP-ChIP_MESCs_Mouse3.20297499
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.03998092
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.99222256
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.97240427
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.94621081
9EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.80795583
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.77994639
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.76945647
12PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.76925425
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75546914
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75546914
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74807604
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.70456934
17CLOCK_20551151_ChIP-Seq_293T_Human2.69574002
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.64275546
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.54947439
20TP53_16413492_ChIP-PET_HCT116_Human2.48248942
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43424878
22EP300_21415370_ChIP-Seq_HL-1_Mouse2.42987526
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39374448
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.33035807
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31641742
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.31206386
27JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26556312
28GBX2_23144817_ChIP-Seq_PC3_Human2.25188015
29CDX2_19796622_ChIP-Seq_MESCs_Mouse2.24767125
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.23005461
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.21603155
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17819902
33TP53_20018659_ChIP-ChIP_R1E_Mouse2.16467076
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse11.3984902
35CJUN_26792858_Chip-Seq_BT549_Human1.95061794
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90316951
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87335447
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.86567118
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84289204
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.83305009
41EZH2_22144423_ChIP-Seq_EOC_Human1.74976845
42AR_21572438_ChIP-Seq_LNCaP_Human1.71317186
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.71259284
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67531036
45BRD4_25478319_ChIP-Seq_HGPS_Human1.63805980
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.59139730
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57491343
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54218479
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.52546347
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48372858
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47140843
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.46209456
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45644380
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43043791
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.41686132
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40907680
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39427611
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.39359829
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39182092
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39127494
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37279885
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.36482567
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35815221
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35364578
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35202293
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33631413
67* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31862521
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.31230534
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30221265
70TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28134507
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28004849
72ZNF274_21170338_ChIP-Seq_K562_Hela1.24106259
73ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23444301
74TBX20_22080862_ChIP-Seq_HEART_Mouse1.23220149
75TBX20_22328084_ChIP-Seq_HEART_Mouse1.23220149
76* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21874008
77* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21874008
78TP53_18474530_ChIP-ChIP_U2OS_Human1.20320802
79SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19824597
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.18332816
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17905298
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.17197405
83ZNF263_19887448_ChIP-Seq_K562_Human1.14971658
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14928834
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13557774
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13338841
87SMAD4_21799915_ChIP-Seq_A2780_Human1.12182019
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11833436
89IRF1_19129219_ChIP-ChIP_H3396_Human1.10926420
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10807179
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09896114
92* ESR2_21235772_ChIP-Seq_MCF-7_Human1.08893182
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07360757
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.06928825
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.06300169
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05581762
97AHR_22903824_ChIP-Seq_MCF-7_Human1.04727484
98SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04700842
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.02807314
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02157874
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01675530
102* SA1_22415368_ChIP-Seq_MEFs_Mouse1.01437212
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00437353
104VDR_22108803_ChIP-Seq_LS180_Human1.00176761
105* SMAD3_21741376_ChIP-Seq_HESCs_Human1.00150877
106BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99193749
107PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98856033
108TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98431523
109KDM2B_26808549_Chip-Seq_K562_Human0.98067367
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.98017140
111TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97541617
112KDM2B_26808549_Chip-Seq_REH_Human0.96923818
113P300_19829295_ChIP-Seq_ESCs_Human0.96824298
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96550833
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96550833
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96303807
117FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95928107
118STAT3_23295773_ChIP-Seq_U87_Human0.95842862
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95681248
120* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95680107
121UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95655436
122BCAT_22108803_ChIP-Seq_LS180_Human0.95207293
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93672799
124* TP53_23651856_ChIP-Seq_MEFs_Mouse0.93660275
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93305496
126FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93200542
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.92928970
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92400212
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92065345
130FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91805401
131AR_25329375_ChIP-Seq_VCAP_Human0.91201519
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90731419
133UBF1/2_26484160_Chip-Seq_HMECs_Human0.89700091
134GATA2_21666600_ChIP-Seq_HMVEC_Human0.89400939
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88734397
136FUS_26573619_Chip-Seq_HEK293_Human0.88131318
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.88102743
138OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87453761
139* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87344379
140MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.87331057
141* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87227170
142ER_23166858_ChIP-Seq_MCF-7_Human0.86321559
143PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85432712
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84381282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.92293225
2MP0005503_abnormal_tendon_morphology4.49452993
3MP0003279_aneurysm3.85152440
4MP0004272_abnormal_basement_membrane3.82124380
5MP0003011_delayed_dark_adaptation3.32027642
6MP0005623_abnormal_meninges_morphology3.31146964
7MP0003385_abnormal_body_wall2.90106888
8MP0005275_abnormal_skin_tensile2.78322713
9MP0009250_abnormal_appendicular_skeleto2.75311840
10MP0003942_abnormal_urinary_system2.46915252
11MP0010368_abnormal_lymphatic_system2.38839691
12MP0003283_abnormal_digestive_organ2.37986500
13MP0001958_emphysema2.33521219
14MP0004858_abnormal_nervous_system2.30840461
15MP0005508_abnormal_skeleton_morphology2.26771801
16MP0000534_abnormal_ureter_morphology2.24154901
17MP0010030_abnormal_orbit_morphology2.22723073
18MP0001879_abnormal_lymphatic_vessel2.19588502
19MP0003705_abnormal_hypodermis_morpholog2.14639422
20MP0002249_abnormal_larynx_morphology2.14468903
21MP0006054_spinal_hemorrhage2.10447923
22MP0009053_abnormal_anal_canal2.01717531
23MP0009384_cardiac_valve_regurgitation1.96395973
24MP0003122_maternal_imprinting1.89005466
25MP0002282_abnormal_trachea_morphology1.87415499
26MP0000049_abnormal_middle_ear1.81168329
27MP0000767_abnormal_smooth_muscle1.79590856
28MP0003950_abnormal_plasma_membrane1.66392749
29MP0002932_abnormal_joint_morphology1.65270335
30MP0008872_abnormal_physiological_respon1.64976462
31MP0002108_abnormal_muscle_morphology1.62098036
32MP0000751_myopathy1.59010011
33MP0001270_distended_abdomen1.58919123
34MP0002938_white_spotting1.58222537
35MP0000428_abnormal_craniofacial_morphol1.56793421
36MP0003755_abnormal_palate_morphology1.52112534
37MP0000733_abnormal_muscle_development1.51431483
38MP0003935_abnormal_craniofacial_develop1.49183257
39MP0009780_abnormal_chondrocyte_physiolo1.46772714
40MP0003091_abnormal_cell_migration1.43518500
41MP0000747_muscle_weakness1.38431714
42MP0003115_abnormal_respiratory_system1.37084999
43MP0003123_paternal_imprinting1.36544749
44MP0003937_abnormal_limbs/digits/tail_de1.34622999
45MP0005367_renal/urinary_system_phenotyp1.34037376
46MP0000516_abnormal_urinary_system1.34037376
47MP0002295_abnormal_pulmonary_circulatio1.33703243
48MP0001299_abnormal_eye_distance/1.30256677
49MP0003221_abnormal_cardiomyocyte_apopto1.29173172
50MP0000537_abnormal_urethra_morphology1.27723657
51MP0000163_abnormal_cartilage_morphology1.27413236
52MP0005257_abnormal_intraocular_pressure1.25640174
53MP0002233_abnormal_nose_morphology1.25193933
54MP0002115_abnormal_skeleton_extremities1.22400368
55MP0002109_abnormal_limb_morphology1.21232556
56MP0000762_abnormal_tongue_morphology1.20840922
57MP0004130_abnormal_muscle_cell1.20097963
58MP0002896_abnormal_bone_mineralization1.19151072
59MP0003566_abnormal_cell_adhesion1.16707949
60MP0005023_abnormal_wound_healing1.16448190
61MP0002128_abnormal_blood_circulation1.15365904
62MP0000462_abnormal_digestive_system1.13335150
63MP0006138_congestive_heart_failure1.12898570
64MP0002116_abnormal_craniofacial_bone1.11536529
65MP0005083_abnormal_biliary_tract1.10700110
66MP0004084_abnormal_cardiac_muscle1.09003603
67MP0005171_absent_coat_pigmentation1.05301018
68MP0000569_abnormal_digit_pigmentation1.04203063
69MP0005595_abnormal_vascular_smooth1.03673142
70MP0000432_abnormal_head_morphology1.03472045
71MP0000538_abnormal_urinary_bladder1.03090558
72MP0001661_extended_life_span1.02223761
73MP0002127_abnormal_cardiovascular_syste1.01405048
74MP0002925_abnormal_cardiovascular_devel1.00025988
75MP0002113_abnormal_skeleton_development0.99728582
76MP0002933_joint_inflammation0.97995907
77MP0001614_abnormal_blood_vessel0.97831369
78MP0000750_abnormal_muscle_regeneration0.97786492
79MP0001243_abnormal_dermal_layer0.96098372
80MP0005390_skeleton_phenotype0.94103788
81MP0004883_abnormal_blood_vessel0.93810083
82MP0002177_abnormal_outer_ear0.92466924
83MP0005197_abnormal_uvea_morphology0.90674316
84MP0000003_abnormal_adipose_tissue0.89683404
85MP0001542_abnormal_bone_strength0.89181945
86MP0002089_abnormal_postnatal_growth/wei0.88226956
87MP0001915_intracranial_hemorrhage0.88098259
88MP0001340_abnormal_eyelid_morphology0.87599739
89MP0005253_abnormal_eye_physiology0.85971025
90MP0000013_abnormal_adipose_tissue0.85737368
91MP0010386_abnormal_urinary_bladder0.85586768
92MP0002114_abnormal_axial_skeleton0.85356968
93MP0005187_abnormal_penis_morphology0.84256451
94MP0004233_abnormal_muscle_weight0.84069064
95MP0003567_abnormal_fetal_cardiomyocyte0.82690456
96MP0002972_abnormal_cardiac_muscle0.82365572
97MP0005076_abnormal_cell_differentiation0.80937044
98MP0002060_abnormal_skin_morphology0.80218579
99MP0010630_abnormal_cardiac_muscle0.80171261
100MP0004036_abnormal_muscle_relaxation0.79405557
101MP0000778_abnormal_nervous_system0.79382727
102MP0005385_cardiovascular_system_phenoty0.78901840
103MP0001544_abnormal_cardiovascular_syste0.78901840
104MP0005165_increased_susceptibility_to0.77415088
105MP0005388_respiratory_system_phenotype0.77367373
106MP0002133_abnormal_respiratory_system0.77367373
107MP0000266_abnormal_heart_morphology0.77155098
108MP0002269_muscular_atrophy0.77082269
109MP0003828_pulmonary_edema0.76740689
110MP0002751_abnormal_autonomic_nervous0.76409983
111* MP0001175_abnormal_lung_morphology0.76341730
112MP0000759_abnormal_skeletal_muscle0.76256791
113MP0005620_abnormal_muscle_contractility0.74849424
114MP0004484_altered_response_of0.73740346
115MP0000372_irregular_coat_pigmentation0.73373716
116MP0004087_abnormal_muscle_fiber0.73212145
117MP0002837_dystrophic_cardiac_calcinosis0.73192051
118MP0002102_abnormal_ear_morphology0.72734494
119MP0002168_other_aberrant_phenotype0.72686578
120MP0004134_abnormal_chest_morphology0.72677773
121MP0004133_heterotaxia0.72532496
122MP0000749_muscle_degeneration0.71853091
123MP0005391_vision/eye_phenotype0.71646420
124MP0009278_abnormal_bone_marrow0.71620114
125MP0002697_abnormal_eye_size0.70606796
126MP0002736_abnormal_nociception_after0.70456668
127MP0005369_muscle_phenotype0.64985982
128MP0005193_abnormal_anterior_eye0.64624359
129MP0002092_abnormal_eye_morphology0.63326438
130MP0002111_abnormal_tail_morphology0.63186681
131MP0006072_abnormal_retinal_apoptosis0.60044540
132MP0005195_abnormal_posterior_eye0.58507912
133MP0005551_abnormal_eye_electrophysiolog0.56348670

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.09617040
2Oral leukoplakia (HP:0002745)5.79291375
3Premature rupture of membranes (HP:0001788)4.98372643
4Shallow orbits (HP:0000586)4.40514618
5Broad metatarsal (HP:0001783)4.23412957
6Ankle contracture (HP:0006466)4.21982451
7Anomalous pulmonary venous return (HP:0010772)4.03902076
8Abnormality of the pulmonary veins (HP:0011718)4.02154681
9Aortic dissection (HP:0002647)4.00745786
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.00706387
11Short 4th metacarpal (HP:0010044)4.00706387
12Hemiplegia (HP:0002301)4.00462653
13Abnormality of dentin (HP:0010299)3.94313494
14Bladder diverticulum (HP:0000015)3.79578152
15Cerebellar dysplasia (HP:0007033)3.79285322
16Type II lissencephaly (HP:0007260)3.76922364
17Aortic aneurysm (HP:0004942)3.57182170
18Cerebral aneurysm (HP:0004944)3.42903493
19Abnormality of the 4th metacarpal (HP:0010012)3.39072980
20Short femoral neck (HP:0100864)3.34208505
21Calf muscle hypertrophy (HP:0008981)3.33123164
22Renal duplication (HP:0000075)3.25856447
23Soft skin (HP:0000977)3.25674043
24Atrophic scars (HP:0001075)3.22094425
25Keratoconus (HP:0000563)3.08117149
26Increased corneal curvature (HP:0100692)3.08117149
27Abnormality of the odontoid process (HP:0003310)2.95507701
28Camptodactyly of toe (HP:0001836)2.95187012
29Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.94524344
30Mesomelia (HP:0003027)2.87522898
31Asymmetry of the thorax (HP:0001555)2.86882287
32Follicular hyperkeratosis (HP:0007502)2.84573152
33Neonatal short-limb short stature (HP:0008921)2.83871225
34Type 1 muscle fiber predominance (HP:0003803)2.79724574
35Muscle hypertrophy of the lower extremities (HP:0008968)2.79651485
36Abnormality of the right ventricle (HP:0001707)2.76185162
37Dilatation of the ascending aorta (HP:0005111)2.75225704
38Fragile skin (HP:0001030)2.73353428
39Mitral valve prolapse (HP:0001634)2.72326798
40Peritonitis (HP:0002586)2.71457377
41Wide anterior fontanel (HP:0000260)2.68079542
42Delayed gross motor development (HP:0002194)2.66862073
43Spinal rigidity (HP:0003306)2.66466289
44Limb-girdle muscle atrophy (HP:0003797)2.65163079
45Bowel diverticulosis (HP:0005222)2.62087699
46Rough bone trabeculation (HP:0100670)2.61803539
47Vertebral compression fractures (HP:0002953)2.58871450
48Increased variability in muscle fiber diameter (HP:0003557)2.58689242
49Wormian bones (HP:0002645)2.55997156
50Vascular tortuosity (HP:0004948)2.51946349
51Biconcave vertebral bodies (HP:0004586)2.50186264
52Deviation of the hallux (HP:0010051)2.48208609
53Infantile muscular hypotonia (HP:0008947)2.45277559
54Midline defect of the nose (HP:0004122)2.44640509
55Broad toe (HP:0001837)2.41414429
56Aplasia/hypoplasia of the femur (HP:0005613)2.39410592
57Aortic regurgitation (HP:0001659)2.39278393
58Blue sclerae (HP:0000592)2.36481279
59Vertebral fusion (HP:0002948)2.34242932
60Overgrowth (HP:0001548)2.34157921
61Ulnar claw (HP:0001178)2.33117823
62Cervical subluxation (HP:0003308)2.33035528
63Abnormality of the calf musculature (HP:0001430)2.32924582
64Spinal cord lesions (HP:0100561)2.32468474
65Syringomyelia (HP:0003396)2.32468474
66Wrist flexion contracture (HP:0001239)2.31674139
67Hypoplasia of the pons (HP:0012110)2.29341819
68Slender build (HP:0001533)2.28930389
69Hallux valgus (HP:0001822)2.28251871
70Abnormality of the pons (HP:0007361)2.26739484
71Flexion contracture of toe (HP:0005830)2.25532579
72Joint contractures involving the joints of the feet (HP:0100492)2.25532579
73Limb-girdle muscle weakness (HP:0003325)2.24674285
74Hepatoblastoma (HP:0002884)2.23227449
75Venous insufficiency (HP:0005293)2.20804890
76Long toe (HP:0010511)2.18843146
77Abnormality of skeletal muscle fiber size (HP:0012084)2.18308078
78Short hallux (HP:0010109)2.16045685
79Hemivertebrae (HP:0002937)2.15694224
80Mesangial abnormality (HP:0001966)2.15204882
81Joint laxity (HP:0001388)2.14287674
82Buphthalmos (HP:0000557)2.13838340
83Increased connective tissue (HP:0009025)2.13736319
84Lymphangioma (HP:0100764)2.13507517
85Achilles tendon contracture (HP:0001771)2.13027778
86Arterial tortuosity (HP:0005116)2.11322711
87Coronal craniosynostosis (HP:0004440)2.10760566
88Hypoventilation (HP:0002791)2.10359395
89Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.09059501
90Difficulty climbing stairs (HP:0003551)2.08228712
91Broad long bones (HP:0005622)2.07848156
92Mitral stenosis (HP:0001718)2.07755145
93Genu recurvatum (HP:0002816)2.04802000
94Hyperextensible skin (HP:0000974)2.04714939
95Frequent falls (HP:0002359)2.04637899
96Shoulder girdle muscle weakness (HP:0003547)2.03303576
97Pathologic fracture (HP:0002756)2.02188354
98Abnormality of the Achilles tendon (HP:0005109)2.01351126
99Venous abnormality (HP:0002624)2.01233892
100Bell-shaped thorax (HP:0001591)2.01174090
101Myelomeningocele (HP:0002475)2.01164133
102Abnormality of the musculature of the pelvis (HP:0001469)2.00975154
103Abnormality of the hip-girdle musculature (HP:0001445)2.00975154
104Amelogenesis imperfecta (HP:0000705)1.98895845
105Aneurysm (HP:0002617)1.98895638
106Upper motor neuron abnormality (HP:0002127)1.98806127
107Aplasia/Hypoplasia of the hallux (HP:0008362)1.98114215
108Redundant skin (HP:0001582)1.97422494
109Knee flexion contracture (HP:0006380)1.97187961
110Meningocele (HP:0002435)1.95761480
111Chorioretinal atrophy (HP:0000533)1.95464476
112Osteopenia (HP:0000938)1.94341140
113Microglossia (HP:0000171)1.93424327
114Mitral regurgitation (HP:0001653)1.92861011
115Short middle phalanx of the 5th finger (HP:0004220)1.91740394
116Pelvic girdle muscle weakness (HP:0003749)1.91563803
117Elbow flexion contracture (HP:0002987)1.90305342
118Protruding ear (HP:0000411)1.89094218
119Morphological abnormality of the pyramidal tract (HP:0002062)1.88879495
120Flat cornea (HP:0007720)1.86683712
121Ectopia lentis (HP:0001083)1.85755436
122Scapular winging (HP:0003691)1.85347008
123Vertebral arch anomaly (HP:0008438)1.84299466
124Narrow nasal bridge (HP:0000446)1.82713422
125Thin bony cortex (HP:0002753)1.82324657
126Thoracolumbar scoliosis (HP:0002944)1.82119751
127Thin skin (HP:0000963)1.82067056
128Abnormality of the ischium (HP:0003174)1.82032157
129Broad hallux (HP:0010055)1.80546669
130Bicuspid aortic valve (HP:0001647)1.79147884
131Abnormality of the peritoneum (HP:0002585)1.78111697
132Neoplasm of the heart (HP:0100544)1.77763696
133Cutaneous finger syndactyly (HP:0010554)1.77639765
134Renovascular hypertension (HP:0100817)1.77603047
135Premature graying of hair (HP:0002216)1.77132489
136Broad ribs (HP:0000885)1.76486561
137Genu valgum (HP:0002857)1.76468772
138Bone cyst (HP:0012062)1.76052065
139Pulmonary artery stenosis (HP:0004415)1.75494914
140Disproportionate tall stature (HP:0001519)1.74554167
141Morphological abnormality of the middle ear (HP:0008609)1.74284686
142Limited hip movement (HP:0008800)1.74277956
143Abnormal trabecular bone morphology (HP:0100671)1.73378816
144Broad phalanx (HP:0006009)1.73275449
145Hyperacusis (HP:0010780)1.72383034
146Abnormality of the intervertebral disk (HP:0005108)1.72088643
147Aortic valve stenosis (HP:0001650)1.71102650
148Drooling (HP:0002307)1.69728360
149Ovoid vertebral bodies (HP:0003300)1.69565776
150Broad distal phalanx of finger (HP:0009836)1.69507336
151Rectal prolapse (HP:0002035)1.68262199
152Prominent supraorbital ridges (HP:0000336)1.67416147
153Gingival overgrowth (HP:0000212)1.67041342
154Selective tooth agenesis (HP:0001592)1.65805880
155Inguinal hernia (HP:0000023)1.65163291
156Hypercalcemia (HP:0003072)1.65126414
157Chondrocalcinosis (HP:0000934)1.65012317

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K46.92444851
2MAP2K76.85345154
3MAP2K44.20166764
4ZAK4.18018644
5PDGFRA3.98944837
6LATS23.80360430
7EPHA33.58476960
8EPHB23.36926446
9MYLK3.16748009
10BLK3.11399508
11TTN2.91707866
12DDR22.91372349
13LMTK22.76336411
14TRIB32.74786557
15LATS12.04198860
16TIE11.99551031
17PAK21.98654278
18KIT1.92644447
19NEK91.92320430
20CLK11.91882431
21DMPK1.85411246
22ROCK11.74552339
23ERN11.70514068
24AKT31.69278338
25NTRK11.66464258
26VRK11.65998943
27PTK2B1.65343386
28ROCK21.61786686
29TLK11.58653583
30LRRK21.58423187
31SIK11.50056051
32GRK11.42168303
33TGFBR21.37709104
34ILK1.32100939
35ADRBK11.31368511
36PAK31.30929209
37PDGFRB1.29718478
38TGFBR11.23436850
39LIMK11.22149094
40FER1.22131006
41BMX1.19207317
42MAPKAPK31.16004767
43STK38L1.12355756
44PTK61.12309732
45ADRBK21.08452157
46RET1.06688918
47PKN21.05677782
48PHKG21.04822992
49PHKG11.04822992
50RIPK11.04400315
51WNK11.02134495
52FRK1.00183021
53MINK10.99413491
54RPS6KA50.98334623
55CDC42BPA0.94115973
56PTK20.93231528
57ERBB40.90100507
58CAMK1G0.88781968
59PIK3CG0.87976253
60BMPR1B0.85197402
61MARK10.81670982
62MAP2K10.78180452
63TRPM70.77162408
64TEC0.77140365
65KDR0.76537733
66FGFR30.74756643
67MELK0.72571213
68RPS6KA40.70874099
69PRKCE0.70873718
70MARK30.69914769
71PAK60.69805556
72MET0.68789303
73PIK3CA0.66268396
74MAP3K100.66200576
75PKN10.64157477
76PLK20.63707034
77DAPK30.62335678
78PRKD10.62163542
79BRSK20.61834214
80MTOR0.60310607
81INSR0.58961686
82MATK0.58949053
83RPS6KA20.58878473
84SCYL20.55307413
85PLK30.55137092
86ERBB30.54657578
87MKNK20.53303583
88CAMK1D0.53261186
89SRC0.50674617
90STK30.49029631
91STK40.47916757
92OBSCN0.47583368
93FGFR10.46623367
94NTRK20.46527534
95PRKAA10.46089178
96ERBB20.45600994
97MKNK10.44590315
98MAP2K20.43498295
99TESK10.42044028
100CASK0.41870626
101EPHB10.41048169
102PRKCI0.40818317
103EEF2K0.39696696
104AURKA0.39695265
105PRKCH0.39570804
106KSR20.39181384
107IGF1R0.38457052
108FGFR40.38307626
109KSR10.36480189
110RPS6KL10.35526422
111RPS6KC10.35526422
112ITK0.34956674
113GRK50.34707277
114MAP3K70.34431920
115INSRR0.34128987
116RPS6KA60.33580676
117CDK80.32614373
118CAMKK20.32600142
119MAP4K20.32442107
120CDK140.32204817
121STK380.31629362
122MAP3K60.31303569
123MAPKAPK20.30710081
124PAK40.30211615
125ABL20.29918226
126CSF1R0.29759786
127EGFR0.29105714
128MUSK0.28824312
129CAMK40.28410083
130PRKD20.28293035
131CAMK2D0.28178731
132CSNK1G10.28140844
133CSNK1A1L0.27808357
134FGFR20.27654127
135CDK90.26312137
136UHMK10.26172626
137JAK10.25646749
138GSK3A0.25079730
139STK390.24613941
140PRKCZ0.21078438
141ACVR1B0.20516736
142CSNK1G20.20062078
143MOS0.19917817
144MAPK110.19261627
145CAMK2G0.19061141

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.05804870
2ECM-receptor interaction_Homo sapiens_hsa045123.37818738
3Alcoholism_Homo sapiens_hsa050343.28244548
4Focal adhesion_Homo sapiens_hsa045102.79954103
5Dilated cardiomyopathy_Homo sapiens_hsa054142.24481840
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.17235916
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.16932305
8Hedgehog signaling pathway_Homo sapiens_hsa043402.16681138
9Basal cell carcinoma_Homo sapiens_hsa052172.11748547
10Adherens junction_Homo sapiens_hsa045202.11284106
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.09485735
12Hippo signaling pathway_Homo sapiens_hsa043902.04846358
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.02722163
14Proteoglycans in cancer_Homo sapiens_hsa052052.01913964
15Small cell lung cancer_Homo sapiens_hsa052221.90673790
16Protein digestion and absorption_Homo sapiens_hsa049741.86384815
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.83408860
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.77575026
19Axon guidance_Homo sapiens_hsa043601.73262732
20Selenocompound metabolism_Homo sapiens_hsa004501.70279647
21MicroRNAs in cancer_Homo sapiens_hsa052061.65972079
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64515123
23Amoebiasis_Homo sapiens_hsa051461.63475763
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.57169836
25TGF-beta signaling pathway_Homo sapiens_hsa043501.53898476
26Viral myocarditis_Homo sapiens_hsa054161.53037206
27Melanoma_Homo sapiens_hsa052181.51837625
28Prostate cancer_Homo sapiens_hsa052151.51207286
29Pathways in cancer_Homo sapiens_hsa052001.41699797
30Glioma_Homo sapiens_hsa052141.39424909
31Gap junction_Homo sapiens_hsa045401.34737844
32Melanogenesis_Homo sapiens_hsa049161.34585600
33Wnt signaling pathway_Homo sapiens_hsa043101.33919971
34Chronic myeloid leukemia_Homo sapiens_hsa052201.26786677
35Regulation of actin cytoskeleton_Homo sapiens_hsa048101.24221174
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24127830
37Rap1 signaling pathway_Homo sapiens_hsa040151.22334462
38Platelet activation_Homo sapiens_hsa046111.21972058
39Sulfur relay system_Homo sapiens_hsa041221.21965390
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20548081
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.19486301
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16243527
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.15900604
44Insulin secretion_Homo sapiens_hsa049111.15854111
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14532255
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.14353337
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11369757
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.09818863
49Colorectal cancer_Homo sapiens_hsa052101.05567952
50Prolactin signaling pathway_Homo sapiens_hsa049171.04239907
51Renin secretion_Homo sapiens_hsa049241.01966500
52Notch signaling pathway_Homo sapiens_hsa043301.01218345
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00721824
54Pancreatic cancer_Homo sapiens_hsa052121.00538148
55Bladder cancer_Homo sapiens_hsa052191.00162405
56Estrogen signaling pathway_Homo sapiens_hsa049150.99796769
57HTLV-I infection_Homo sapiens_hsa051660.99350676
58Tight junction_Homo sapiens_hsa045300.99240436
59ErbB signaling pathway_Homo sapiens_hsa040120.99214523
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98105791
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.97621988
62Dorso-ventral axis formation_Homo sapiens_hsa043200.95974039
63Toxoplasmosis_Homo sapiens_hsa051450.94883053
64Sulfur metabolism_Homo sapiens_hsa009200.94723160
65Endometrial cancer_Homo sapiens_hsa052130.94718867
66Choline metabolism in cancer_Homo sapiens_hsa052310.92403463
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88492568
68Calcium signaling pathway_Homo sapiens_hsa040200.87870608
69Viral carcinogenesis_Homo sapiens_hsa052030.87570898
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.86997944
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86783414
72Malaria_Homo sapiens_hsa051440.85680220
73B cell receptor signaling pathway_Homo sapiens_hsa046620.85346722
74Cholinergic synapse_Homo sapiens_hsa047250.83613083
75Tryptophan metabolism_Homo sapiens_hsa003800.83486900
76Pancreatic secretion_Homo sapiens_hsa049720.82495568
77Morphine addiction_Homo sapiens_hsa050320.80538528
78ABC transporters_Homo sapiens_hsa020100.79832207
79Type II diabetes mellitus_Homo sapiens_hsa049300.79541168
80Ras signaling pathway_Homo sapiens_hsa040140.79127290
81Renal cell carcinoma_Homo sapiens_hsa052110.78730211
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78638611
83VEGF signaling pathway_Homo sapiens_hsa043700.78406776
84Thyroid cancer_Homo sapiens_hsa052160.78230074
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.76913051
86GnRH signaling pathway_Homo sapiens_hsa049120.75552041
87Hepatitis B_Homo sapiens_hsa051610.74718562
88Oxytocin signaling pathway_Homo sapiens_hsa049210.74523166
89Insulin resistance_Homo sapiens_hsa049310.74216180
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72769447
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71544755
92cAMP signaling pathway_Homo sapiens_hsa040240.68900731
93Gastric acid secretion_Homo sapiens_hsa049710.67472973
94Inositol phosphate metabolism_Homo sapiens_hsa005620.66902190
95MAPK signaling pathway_Homo sapiens_hsa040100.66123190
96Shigellosis_Homo sapiens_hsa051310.65566341
97HIF-1 signaling pathway_Homo sapiens_hsa040660.65339840
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64371349
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61226964
100Insulin signaling pathway_Homo sapiens_hsa049100.60829066
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60653021
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60522504
103Circadian entrainment_Homo sapiens_hsa047130.59170391
104TNF signaling pathway_Homo sapiens_hsa046680.58907212
105Oocyte meiosis_Homo sapiens_hsa041140.58499954
106Renin-angiotensin system_Homo sapiens_hsa046140.56141017
107Phototransduction_Homo sapiens_hsa047440.56041501
108Thyroid hormone synthesis_Homo sapiens_hsa049180.56012699
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54833490
110Dopaminergic synapse_Homo sapiens_hsa047280.54751656
111Salivary secretion_Homo sapiens_hsa049700.53194435
112Endocytosis_Homo sapiens_hsa041440.52757273
113Cardiac muscle contraction_Homo sapiens_hsa042600.52483784
114Ovarian steroidogenesis_Homo sapiens_hsa049130.50755519
115Cocaine addiction_Homo sapiens_hsa050300.50696744
116FoxO signaling pathway_Homo sapiens_hsa040680.50413373
117Glutamatergic synapse_Homo sapiens_hsa047240.49138447
118* Sphingolipid signaling pathway_Homo sapiens_hsa040710.48571144
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47794239
120Long-term depression_Homo sapiens_hsa047300.47713428
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47476629
122Bile secretion_Homo sapiens_hsa049760.46695017
123mTOR signaling pathway_Homo sapiens_hsa041500.46467199
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46056430
125Apoptosis_Homo sapiens_hsa042100.45526566
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45298469
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45210881
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45100599
129Caffeine metabolism_Homo sapiens_hsa002320.44773272
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43380117
131Osteoclast differentiation_Homo sapiens_hsa043800.43041601
132Phagosome_Homo sapiens_hsa041450.42100344
133Cell cycle_Homo sapiens_hsa041100.41923664

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