S100A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1long-chain fatty acid biosynthetic process (GO:0042759)9.03573702
2water homeostasis (GO:0030104)8.66719510
3hair cycle (GO:0042633)8.49589585
4molting cycle (GO:0042303)8.49589585
5* epidermis development (GO:0008544)8.36425540
6detection of bacterium (GO:0016045)8.25554755
7keratinocyte proliferation (GO:0043616)8.14846989
8bundle of His cell to Purkinje myocyte communication (GO:0086069)7.70728905
9lipoxygenase pathway (GO:0019372)7.58351072
10detection of other organism (GO:0098543)7.57262256
11phosphatidylinositol acyl-chain remodeling (GO:0036149)7.52244917
12phosphatidylserine acyl-chain remodeling (GO:0036150)7.41015118
13linoleic acid metabolic process (GO:0043651)7.01688166
14skin morphogenesis (GO:0043589)6.56136834
15regulation of natural killer cell differentiation (GO:0032823)6.26872197
16gap junction assembly (GO:0016264)6.06491720
17phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.97537998
18negative regulation of interferon-gamma production (GO:0032689)5.80430212
19phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.65080731
20intermediate filament cytoskeleton organization (GO:0045104)5.50780661
21phosphatidylcholine acyl-chain remodeling (GO:0036151)5.33403910
22intermediate filament-based process (GO:0045103)5.33138695
23intermediate filament organization (GO:0045109)5.33006799
24negative regulation of interleukin-17 production (GO:0032700)4.99120487
25surfactant homeostasis (GO:0043129)4.92896373
26ectoderm development (GO:0007398)4.86348628
27hemidesmosome assembly (GO:0031581)4.79093426
28phosphatidylserine metabolic process (GO:0006658)4.63578350
29establishment of tissue polarity (GO:0007164)4.57210971
30establishment of planar polarity (GO:0001736)4.57210971
31detection of external biotic stimulus (GO:0098581)4.45068919
32chemical homeostasis within a tissue (GO:0048875)4.10686280
33ceramide biosynthetic process (GO:0046513)4.08277154
34keratinocyte development (GO:0003334)4.04802325
35phospholipid catabolic process (GO:0009395)3.98437702
36* epithelium development (GO:0060429)3.84494867
37detection of biotic stimulus (GO:0009595)3.78275095
38alditol phosphate metabolic process (GO:0052646)3.74692385
39polarized epithelial cell differentiation (GO:0030859)3.67544453
40defense response to fungus (GO:0050832)3.44131466
41lateral sprouting from an epithelium (GO:0060601)3.39002653
42epithelial cell differentiation involved in prostate gland development (GO:0060742)3.33098504
43phospholipid efflux (GO:0033700)3.20768631
44positive regulation of epidermis development (GO:0045684)3.18266741
45negative regulation of keratinocyte proliferation (GO:0010839)3.17858428
46regulation of keratinocyte differentiation (GO:0045616)3.09908671
47keratinization (GO:0031424)26.1967704
48positive regulation of epidermal cell differentiation (GO:0045606)2.99452964
49regulation of keratinocyte proliferation (GO:0010837)2.99271801
50phosphatidylglycerol metabolic process (GO:0046471)2.97703724
51eyelid development in camera-type eye (GO:0061029)2.96564504
52regulation of natural killer cell activation (GO:0032814)2.94478660
53* epithelial cell differentiation (GO:0030855)2.92689170
54ventricular cardiac muscle cell action potential (GO:0086005)2.92646885
55positive regulation of cholesterol efflux (GO:0010875)2.86717172
56regulation of neuron projection regeneration (GO:0070570)2.84936853
57regulation of axon regeneration (GO:0048679)2.84936853
58regulation of interleukin-17 production (GO:0032660)2.78012875
59planar cell polarity pathway involved in neural tube closure (GO:0090179)2.77454019
60leukocyte aggregation (GO:0070486)2.73028724
61regulation of epidermis development (GO:0045682)2.66967363
62regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.66549400
63hair follicle morphogenesis (GO:0031069)2.63191843
64sphingolipid biosynthetic process (GO:0030148)2.61932059
65regulation of heart rate by cardiac conduction (GO:0086091)2.56910036
66antimicrobial humoral response (GO:0019730)2.56397386
67phosphatidic acid biosynthetic process (GO:0006654)2.53162765
68phosphatidic acid metabolic process (GO:0046473)2.53162765
69positive regulation of cholesterol transport (GO:0032376)2.47622033
70positive regulation of sterol transport (GO:0032373)2.47622033
71cell communication involved in cardiac conduction (GO:0086065)2.41961230
72response to UV-B (GO:0010224)2.41076943
73regulation of protein localization to cell surface (GO:2000008)2.40079562
74response to zinc ion (GO:0010043)2.39724380
75regulation of epidermal cell differentiation (GO:0045604)2.39381514
76negative regulation of lymphocyte differentiation (GO:0045620)2.36537416
77skin development (GO:0043588)2.36253878
78intestinal epithelial cell development (GO:0060576)2.31420844
79hair cell differentiation (GO:0035315)2.29416674
80unsaturated fatty acid biosynthetic process (GO:0006636)2.29073698
81response to fungus (GO:0009620)2.25228831
82positive regulation of keratinocyte differentiation (GO:0045618)2.25150945
83response to phenylpropanoid (GO:0080184)2.24372399
84fatty acid elongation (GO:0030497)2.23960443
85chronic inflammatory response (GO:0002544)2.23745248
86atrioventricular valve morphogenesis (GO:0003181)2.23484739
87one-carbon compound transport (GO:0019755)2.17402694
88mitotic G1 DNA damage checkpoint (GO:0031571)2.17297955
89phosphatidylcholine metabolic process (GO:0046470)2.16947421
90polyol transport (GO:0015791)2.13077224
91cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.11568594
92negative regulation of interleukin-6 production (GO:0032715)2.10609338
93positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.06889786
94establishment of skin barrier (GO:0061436)19.0757626
95regulation of water loss via skin (GO:0033561)16.4548077
96* keratinocyte differentiation (GO:0030216)13.8205369
97desmosome organization (GO:0002934)11.5097329
98* epidermal cell differentiation (GO:0009913)10.5468739
99peptide cross-linking (GO:0018149)10.4645487
100multicellular organismal water homeostasis (GO:0050891)10.4467264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.30343565
2P63_26484246_Chip-Seq_KERATINOCYTES_Human4.28786615
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.49275259
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.41026942
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.94037133
6SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.50420727
7SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.50420727
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.16082002
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.09274701
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.08564099
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.07179728
12TP63_17297297_ChIP-ChIP_HaCaT_Human14.3308073
13TP63_23658742_ChIP-Seq_EP156T_Human1.98261388
14STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87454199
15EGR1_19032775_ChIP-ChIP_M12_Human1.84158116
16* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.79770137
17TP63_22573176_ChIP-Seq_HFKS_Human1.75380052
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74544814
19ZNF263_19887448_ChIP-Seq_K562_Human1.70125316
20ERG_20517297_ChIP-Seq_VCAP_Human1.65114691
21VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.62791414
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62706443
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.48990814
24RXR_22108803_ChIP-Seq_LS180_Human1.48619552
25ATF3_27146783_Chip-Seq_COLON_Human1.48423051
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47576481
27* GATA6_21074721_ChIP-Seq_CACO-2_Human1.47202588
28KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46737236
29SOX2_20726797_ChIP-Seq_SW620_Human1.43814598
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40840989
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39031841
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.33822897
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30433044
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26404164
35RACK7_27058665_Chip-Seq_MCF-7_Human1.24102985
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.24081865
37GATA3_24758297_ChIP-Seq_MCF-7_Human1.21947571
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20581528
39KLF5_25053715_ChIP-Seq_YYC3_Human1.19958776
40* SMC4_20622854_ChIP-Seq_HELA_Human1.14250276
41UBF1/2_26484160_Chip-Seq_HMECs_Human1.11356813
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10130735
43BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.07051629
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04087948
45FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03331975
46* E2F1_20622854_ChIP-Seq_HELA_Human1.03219486
47TCF4_18268006_ChIP-ChIP_LS174T_Human1.02924862
48CLOCK_20551151_ChIP-Seq_293T_Human1.01058167
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00980802
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99770874
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99761058
52* CTCF_27219007_Chip-Seq_Bcells_Human0.98845243
53* CJUN_26792858_Chip-Seq_BT549_Human0.98084052
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97298009
55CTCF_20526341_ChIP-Seq_ESCs_Human0.97269527
56* BCOR_27268052_Chip-Seq_Bcells_Human0.96005461
57AHR_22903824_ChIP-Seq_MCF-7_Human0.95995408
58SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95470673
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94585577
60P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.93574402
61P53_21459846_ChIP-Seq_SAOS-2_Human0.90408224
62HTT_18923047_ChIP-ChIP_STHdh_Human0.88382524
63FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85327411
64JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84775056
65* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84329694
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83615717
67GATA6_25053715_ChIP-Seq_YYC3_Human0.83560736
68GATA4_25053715_ChIP-Seq_YYC3_Human0.82403738
69LXR_22292898_ChIP-Seq_THP-1_Human0.81660877
70SA1_27219007_Chip-Seq_ERYTHROID_Human0.79088427
71AR_21572438_ChIP-Seq_LNCaP_Human0.78318572
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78192910
73GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.75620685
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73784968
75* RBPJ_21746931_ChIP-Seq_IB4_Human0.73455251
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72701403
77BCL6_27268052_Chip-Seq_Bcells_Human0.72215282
78ELK3_25401928_ChIP-Seq_HUVEC_Human0.71868064
79NCOR_22424771_ChIP-Seq_293T_Human0.71515771
80ERG_21242973_ChIP-ChIP_JURKAT_Human0.70929334
81GATA2_19941826_ChIP-Seq_K562_Human0.70457446
82JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67009584
83TP53_18474530_ChIP-ChIP_U2OS_Human0.66882528
84ARNT_22903824_ChIP-Seq_MCF-7_Human0.65502678
85SRY_22984422_ChIP-ChIP_TESTIS_Rat0.64538599
86SPI1_20517297_ChIP-Seq_HL60_Human0.63917028
87* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.62972320
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.62791310
89CEBPB_22108803_ChIP-Seq_LS180_Human0.61417482
90* P300_27268052_Chip-Seq_Bcells_Human0.61017128
91TBX20_22328084_ChIP-Seq_HEART_Mouse0.60162894
92TBX20_22080862_ChIP-Seq_HEART_Mouse0.60162894
93* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.60094821
94PPARA_22158963_ChIP-Seq_LIVER_Mouse0.59119366
95* TAF2_19829295_ChIP-Seq_ESCs_Human0.59050620
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.58988649
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.58528059
98SMAD4_21741376_ChIP-Seq_ESCs_Human0.57755550
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57462981
100* HNFA_21074721_ChIP-Seq_CACO-2_Human0.57096210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.80889497
2MP0005275_abnormal_skin_tensile7.20502548
3MP0000579_abnormal_nail_morphology5.82921366
4MP0010234_abnormal_vibrissa_follicle5.74883394
5MP0005501_abnormal_skin_physiology5.41880823
6MP0005377_hearing/vestibular/ear_phenot3.38565241
7MP0003878_abnormal_ear_physiology3.38565241
8MP0004885_abnormal_endolymph3.38002381
9MP0003941_abnormal_skin_development3.36160024
10MP0001216_abnormal_epidermal_layer3.17095433
11MP0003453_abnormal_keratinocyte_physiol3.12939998
12MP0010771_integument_phenotype2.73637201
13MP0010678_abnormal_skin_adnexa2.64874718
14MP0002060_abnormal_skin_morphology2.64779052
15MP0004381_abnormal_hair_follicle2.35643036
16MP0003191_abnormal_cellular_cholesterol2.33179298
17MP0000467_abnormal_esophagus_morphology2.23549173
18MP0005409_darkened_coat_color2.22976090
19MP0004947_skin_inflammation2.21106081
20MP0000383_abnormal_hair_follicle2.21044788
21MP0000377_abnormal_hair_follicle2.05787272
22MP0001188_hyperpigmentation1.92769299
23MP0004264_abnormal_extraembryonic_tissu1.88548392
24MP0003705_abnormal_hypodermis_morpholog1.86082204
25MP0002098_abnormal_vibrissa_morphology1.83446701
26MP0004782_abnormal_surfactant_physiolog1.81541415
27MP0009931_abnormal_skin_appearance1.69085253
28MP0010352_gastrointestinal_tract_polyps1.54156007
29MP0003566_abnormal_cell_adhesion1.45083168
30MP0000762_abnormal_tongue_morphology1.37839390
31MP0002095_abnormal_skin_pigmentation1.30496770
32MP0001191_abnormal_skin_condition1.30154940
33MP0000427_abnormal_hair_cycle1.24523953
34MP0000465_gastrointestinal_hemorrhage1.23671980
35MP0000367_abnormal_coat/_hair1.18912249
36MP0003011_delayed_dark_adaptation1.17833041
37MP0000647_abnormal_sebaceous_gland1.17479938
38MP0000566_synostosis1.11529722
39MP0009379_abnormal_foot_pigmentation1.02901175
40MP0001851_eye_inflammation0.97886835
41MP0005023_abnormal_wound_healing0.87953237
42MP0009053_abnormal_anal_canal0.86259766
43MP0001784_abnormal_fluid_regulation0.81312527
44MP0004185_abnormal_adipocyte_glucose0.76211435
45MP0001243_abnormal_dermal_layer0.73171103
46MP0008004_abnormal_stomach_pH0.66893432
47MP0001485_abnormal_pinna_reflex0.65399085
48MP0002177_abnormal_outer_ear0.62461565
49MP0000015_abnormal_ear_pigmentation0.57772651
50MP0002234_abnormal_pharynx_morphology0.55009248
51MP0002877_abnormal_melanocyte_morpholog0.52072818
52MP0003315_abnormal_perineum_morphology0.50347649
53MP0004043_abnormal_pH_regulation0.43349341
54MP0000569_abnormal_digit_pigmentation0.42037162
55MP0005075_abnormal_melanosome_morpholog0.41808570
56MP0005174_abnormal_tail_pigmentation0.39732186
57MP0002111_abnormal_tail_morphology0.37532497
58MP0003763_abnormal_thymus_physiology0.36997055
59MP0001340_abnormal_eyelid_morphology0.34431760
60MP0008438_abnormal_cutaneous_collagen0.34049000
61MP0005503_abnormal_tendon_morphology0.33831417
62MP0001186_pigmentation_phenotype0.32918087
63MP0005257_abnormal_intraocular_pressure0.32112819
64MP0003950_abnormal_plasma_membrane0.31925097
65MP0000627_abnormal_mammary_gland0.30292332
66MP0002138_abnormal_hepatobiliary_system0.29627345
67MP0003300_gastrointestinal_ulcer0.28066468
68MP0002006_tumorigenesis0.27629029
69MP0009333_abnormal_splenocyte_physiolog0.27122899
70MP0002166_altered_tumor_susceptibility0.26894821
71MP0005388_respiratory_system_phenotype0.26812392
72MP0002133_abnormal_respiratory_system0.26812392
73MP0005171_absent_coat_pigmentation0.26183926
74MP0000685_abnormal_immune_system0.25886990
75MP0010030_abnormal_orbit_morphology0.25881561
76MP0004197_abnormal_fetal_growth/weight/0.25536781
77MP0005666_abnormal_adipose_tissue0.25411502
78MP0002282_abnormal_trachea_morphology0.25122913
79MP0002009_preneoplasia0.23529226
80MP0001177_atelectasis0.22495365
81MP0003755_abnormal_palate_morphology0.22487220
82MP0003638_abnormal_response/metabolism_0.19141433
83MP0008789_abnormal_olfactory_epithelium0.18755109
84MP0005375_adipose_tissue_phenotype0.18144152
85MP0000858_altered_metastatic_potential0.17297569
86MP0002075_abnormal_coat/hair_pigmentati0.16749492
87MP0003436_decreased_susceptibility_to0.16415267
88MP0005499_abnormal_olfactory_system0.15743685
89MP0005394_taste/olfaction_phenotype0.15743685
90MP0000372_irregular_coat_pigmentation0.14973351
91MP0005193_abnormal_anterior_eye0.14400742
92MP0000470_abnormal_stomach_morphology0.13239488
93MP0003045_fibrosis0.12460775
94MP0008260_abnormal_autophagy0.12157946
95MP0009672_abnormal_birth_weight0.12034621
96MP0000371_diluted_coat_color0.11341173
97MP0005408_hypopigmentation0.10719344
98MP0005076_abnormal_cell_differentiation0.09896433
99MP0008569_lethality_at_weaning0.09656423
100MP0003448_altered_tumor_morphology0.09641953

Predicted human phenotypes

RankGene SetZ-score
1Palmoplantar hyperkeratosis (HP:0000972)9.08056212
2Palmar hyperkeratosis (HP:0010765)8.64264041
3Increased IgE level (HP:0003212)8.40902447
4Erythroderma (HP:0001019)8.29209742
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.70721871
6Oral leukoplakia (HP:0002745)7.55688353
7Congenital ichthyosiform erythroderma (HP:0007431)7.54793235
8Plantar hyperkeratosis (HP:0007556)7.31662646
9Alopecia of scalp (HP:0002293)7.11958252
10Onycholysis (HP:0001806)6.80527299
11Thick nail (HP:0001805)6.29042996
12Abnormality of secondary sexual hair (HP:0009888)6.13153209
13Abnormality of the axillary hair (HP:0100134)6.13153209
14Corneal erosion (HP:0200020)5.76881920
15Erythema (HP:0010783)5.66832266
16Parakeratosis (HP:0001036)5.63894616
17Hypotrichosis (HP:0001006)5.62772509
18Gangrene (HP:0100758)4.45041036
19Hypohidrosis (HP:0000966)4.36292950
20Ectropion (HP:0000656)4.32799920
21Conjunctival hamartoma (HP:0100780)4.27533759
22Palmoplantar keratoderma (HP:0000982)4.17844392
23Right ventricular cardiomyopathy (HP:0011663)4.01450855
24Nail dystrophy (HP:0008404)4.00842549
25Sparse eyelashes (HP:0000653)3.74745288
26Absent eyelashes (HP:0000561)3.73476039
27Absent hair (HP:0002298)3.63320488
28Follicular hyperkeratosis (HP:0007502)3.46042284
29Pustule (HP:0200039)3.35049718
30Woolly hair (HP:0002224)3.31260151
31Abnormality of placental membranes (HP:0011409)3.27941689
32Amniotic constriction ring (HP:0009775)3.27941689
33Fragile nails (HP:0001808)3.10426257
34Furrowed tongue (HP:0000221)3.09958118
35Abnormal blistering of the skin (HP:0008066)3.03264726
36Sparse scalp hair (HP:0002209)2.93221681
37Lip pit (HP:0100267)2.89704813
38Hamartoma of the eye (HP:0010568)2.84225916
39Pruritus (HP:0000989)2.82003582
40Abnormality of the salivary glands (HP:0010286)2.78353884
41Lack of skin elasticity (HP:0100679)2.71089304
42Blepharitis (HP:0000498)2.68115027
43Autoamputation (HP:0001218)2.60981825
44Eczematoid dermatitis (HP:0000976)2.45908151
45Ridged nail (HP:0001807)2.37464292
46Urticaria (HP:0001025)2.33491468
47Brittle hair (HP:0002299)2.28291410
48Abnormal hair laboratory examination (HP:0003328)2.26016211
49Multifactorial inheritance (HP:0001426)2.25872006
50Hypergammaglobulinemia (HP:0010702)2.22493124
51Laryngomalacia (HP:0001601)2.18529931
52Pili torti (HP:0003777)2.16301068
53Paralysis (HP:0003470)2.13091354
54Dehydration (HP:0001944)2.10304042
55Recurrent corneal erosions (HP:0000495)2.01698649
56Abnormality of nail color (HP:0100643)13.6843933
57Keratoconjunctivitis sicca (HP:0001097)1.95041673
58Abnormality of hair growth rate (HP:0011363)1.94730537
59Slow-growing hair (HP:0002217)1.94730537
60Selective tooth agenesis (HP:0001592)1.94293892
61Milia (HP:0001056)1.91792036
62Hyperhidrosis (HP:0000975)1.90702870
63Natal tooth (HP:0000695)1.88059507
64Melanocytic nevus (HP:0000995)1.87276098
65Hypoplastic labia majora (HP:0000059)1.84065609
66Anonychia (HP:0001798)1.81157712
67Recurrent bacterial skin infections (HP:0005406)1.78052065
68Sepsis (HP:0100806)1.77341360
69Keratoconjunctivitis (HP:0001096)1.76177429
70Advanced eruption of teeth (HP:0006288)1.74654340
71Skin ulcer (HP:0200042)1.72088984
72Corneal dystrophy (HP:0001131)1.71791745
73Carious teeth (HP:0000670)1.71481469
74Hypoplastic toenails (HP:0001800)1.68594892
75Abnormality of the labia majora (HP:0012881)1.66812014
76Fine hair (HP:0002213)1.66045142
77Duplicated collecting system (HP:0000081)1.55895765
78Xerostomia (HP:0000217)1.55721244
79Abnormality of the fingernails (HP:0001231)1.54595850
80Dry skin (HP:0000958)1.54069183
81Preauricular skin tag (HP:0000384)1.53615151
82Generalized hyperpigmentation (HP:0007440)1.48796903
83Verrucae (HP:0200043)1.48135520
84Papilloma (HP:0012740)1.48135520
85Septate vagina (HP:0001153)1.42817168
86Acanthosis nigricans (HP:0000956)1.41490683
87Split foot (HP:0001839)1.36603803
88Hamartoma (HP:0010566)1.33782228
89Skin tags (HP:0010609)1.31190581
90Abnormality of the renal collecting system (HP:0004742)1.31059535
91Curly hair (HP:0002212)1.27072996
92Breast hypoplasia (HP:0003187)1.26302112
93Fatigable weakness (HP:0003473)1.24898680
94Abnormality of the neuromuscular junction (HP:0003398)1.24898680
95Depressed nasal tip (HP:0000437)1.24897292
96Recurrent skin infections (HP:0001581)1.24298606
97Nasolacrimal duct obstruction (HP:0000579)1.23692731
98Ventricular tachycardia (HP:0004756)1.21357813
99Villous atrophy (HP:0011473)1.19145606
100Abnormality of small intestinal villus morphology (HP:0011472)1.19145606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR15.91176676
2FER4.15926146
3MAP3K63.83229982
4EPHA33.71414988
5EPHA23.15730972
6MAP3K23.00890751
7MAP3K92.69239228
8MAPKAPK32.61166297
9FGFR12.51164205
10ERN12.45831352
11STK242.43457252
12EPHB12.40600371
13FGFR42.40191266
14FGFR32.34530043
15RIPK12.31211262
16MAP3K32.28223869
17LATS12.25448414
18GRK62.01252783
19IRAK11.79486374
20SGK4941.65831098
21SGK2231.65831098
22PBK1.50781795
23MST1R1.50492245
24MAP3K11.46398944
25PTK21.40175467
26IKBKB1.36588071
27LATS21.32670921
28BMPR21.24647748
29MET1.18854801
30MAP2K61.15416027
31ERBB31.13976127
32TAOK11.13094030
33CDK121.12560699
34BLK1.06664801
35TRPM71.05181610
36NLK1.04862869
37RPS6KB21.01446506
38MAPK71.01281444
39PDGFRA0.97167542
40JAK30.89155599
41STK38L0.88779909
42RET0.81535794
43PIK3CG0.79623439
44MATK0.79531381
45EPHB20.78692718
46JAK10.75145780
47STK30.75099001
48MAPKAPK20.71001336
49MAP3K120.70766984
50PRPF4B0.70607359
51IRAK30.70545501
52TRIB30.68397167
53CDC42BPA0.64589123
54RPS6KB10.62174116
55MST40.61514187
56DMPK0.59208195
57KSR20.58290855
58STK380.57098802
59MARK20.56675348
60HIPK20.53478086
61SIK30.52385546
62KIT0.51552996
63SMG10.51221749
64MTOR0.48377439
65IKBKE0.47720019
66BCR0.47537285
67GSK3A0.45280040
68SGK10.42316027
69PRKD20.39646395
70FGR0.37990320
71TTN0.37022609
72ABL20.36927850
73WNK10.36538641
74SIK10.34157625
75CDK60.33833734
76HCK0.33241748
77KSR10.32655475
78PDGFRB0.31779410
79MAPK120.31130385
80LRRK20.30234597
81MAP3K70.29968520
82PTK60.27727092
83TGFBR20.27497220
84ABL10.27490574
85PRKCE0.27267303
86ADRBK10.26201185
87RPS6KA40.26183806
88MAPKAPK50.25383127
89PRKAA20.25377580
90JAK20.24886304
91PDK20.24689115
92SGK30.24013527
93MAP3K130.23582315
94NEK60.22912681
95EEF2K0.22178132
96ERBB20.21362299
97ICK0.21295662
98FLT30.20997635
99SGK20.20815303
100MAPK90.20734346

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005927.11541688
2Linoleic acid metabolism_Homo sapiens_hsa005915.78138028
3Ether lipid metabolism_Homo sapiens_hsa005654.11539861
4Arachidonic acid metabolism_Homo sapiens_hsa005903.96961129
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.60433309
6GnRH signaling pathway_Homo sapiens_hsa049122.45265415
7Ovarian steroidogenesis_Homo sapiens_hsa049132.33803139
8VEGF signaling pathway_Homo sapiens_hsa043702.32871752
9Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.08894571
10Staphylococcus aureus infection_Homo sapiens_hsa051502.06883448
11Sphingolipid metabolism_Homo sapiens_hsa006001.97281038
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.89062508
13Long-term depression_Homo sapiens_hsa047301.85463379
14Histidine metabolism_Homo sapiens_hsa003401.82353726
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.77992995
16Phototransduction_Homo sapiens_hsa047441.71024715
17Amoebiasis_Homo sapiens_hsa051461.67866959
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.58340840
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51188897
20Choline metabolism in cancer_Homo sapiens_hsa052311.39281268
21Serotonergic synapse_Homo sapiens_hsa047261.38676565
22Renin secretion_Homo sapiens_hsa049241.25955261
23Ras signaling pathway_Homo sapiens_hsa040141.13979665
24Platelet activation_Homo sapiens_hsa046111.04989513
25Pertussis_Homo sapiens_hsa051331.00497605
26Glioma_Homo sapiens_hsa052140.99929510
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98660022
28Acute myeloid leukemia_Homo sapiens_hsa052210.93614076
29Phenylalanine metabolism_Homo sapiens_hsa003600.88927164
30Fat digestion and absorption_Homo sapiens_hsa049750.88873802
31Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87072363
32Phospholipase D signaling pathway_Homo sapiens_hsa040720.86401764
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84700194
34Sphingolipid signaling pathway_Homo sapiens_hsa040710.80595013
35Oxytocin signaling pathway_Homo sapiens_hsa049210.80593380
36ABC transporters_Homo sapiens_hsa020100.76786109
37Circadian rhythm_Homo sapiens_hsa047100.72360730
38Glutamatergic synapse_Homo sapiens_hsa047240.71542486
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69619459
40MicroRNAs in cancer_Homo sapiens_hsa052060.67395173
41Dorso-ventral axis formation_Homo sapiens_hsa043200.66871591
42Bladder cancer_Homo sapiens_hsa052190.66086628
43Tuberculosis_Homo sapiens_hsa051520.64750523
44Pancreatic secretion_Homo sapiens_hsa049720.64142444
45Melanogenesis_Homo sapiens_hsa049160.64038028
46Gastric acid secretion_Homo sapiens_hsa049710.62126607
47Long-term potentiation_Homo sapiens_hsa047200.62034996
48Adherens junction_Homo sapiens_hsa045200.61844004
49Estrogen signaling pathway_Homo sapiens_hsa049150.57503542
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.57165536
51ECM-receptor interaction_Homo sapiens_hsa045120.56977335
52Pancreatic cancer_Homo sapiens_hsa052120.54475742
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48278391
54Renal cell carcinoma_Homo sapiens_hsa052110.46302830
55Fatty acid elongation_Homo sapiens_hsa000620.45620018
56Thyroid cancer_Homo sapiens_hsa052160.44888856
57Influenza A_Homo sapiens_hsa051640.44288283
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.43757206
59p53 signaling pathway_Homo sapiens_hsa041150.42847049
60Insulin signaling pathway_Homo sapiens_hsa049100.42730275
61MAPK signaling pathway_Homo sapiens_hsa040100.42538262
62Salivary secretion_Homo sapiens_hsa049700.42210672
63HIF-1 signaling pathway_Homo sapiens_hsa040660.42085880
64Toxoplasmosis_Homo sapiens_hsa051450.40011219
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.38083590
66Proteoglycans in cancer_Homo sapiens_hsa052050.37695388
67Arginine biosynthesis_Homo sapiens_hsa002200.36718788
68Rap1 signaling pathway_Homo sapiens_hsa040150.33638932
69Hepatitis C_Homo sapiens_hsa051600.33126071
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32726463
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.30822280
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30764424
73Renin-angiotensin system_Homo sapiens_hsa046140.29708360
74beta-Alanine metabolism_Homo sapiens_hsa004100.28836940
75Tyrosine metabolism_Homo sapiens_hsa003500.28336083
76Retinol metabolism_Homo sapiens_hsa008300.28110892
77Endocytosis_Homo sapiens_hsa041440.27684906
78Leishmaniasis_Homo sapiens_hsa051400.26824222
79Inositol phosphate metabolism_Homo sapiens_hsa005620.26582688
80ErbB signaling pathway_Homo sapiens_hsa040120.26129498
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24489318
82Malaria_Homo sapiens_hsa051440.24339296
83TNF signaling pathway_Homo sapiens_hsa046680.23919991
84Shigellosis_Homo sapiens_hsa051310.23505758
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.22396856
86Glucagon signaling pathway_Homo sapiens_hsa049220.22245457
87Salmonella infection_Homo sapiens_hsa051320.22161713
88Asthma_Homo sapiens_hsa053100.21789096
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21156200
90Notch signaling pathway_Homo sapiens_hsa043300.20624500
91Protein digestion and absorption_Homo sapiens_hsa049740.20608174
92PPAR signaling pathway_Homo sapiens_hsa033200.20588438
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20230809
94Phagosome_Homo sapiens_hsa041450.19810312
95Axon guidance_Homo sapiens_hsa043600.19710663
96Mineral absorption_Homo sapiens_hsa049780.19287079
97Amphetamine addiction_Homo sapiens_hsa050310.18882561
98Focal adhesion_Homo sapiens_hsa045100.18377869
99Pathways in cancer_Homo sapiens_hsa052000.18199792
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17813419

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