S100A12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte migration involved in inflammatory response (GO:0002523)7.70690292
2leukocyte aggregation (GO:0070486)7.59641632
3neutrophil activation involved in immune response (GO:0002283)6.56791383
4detection of other organism (GO:0098543)6.45676390
5detection of bacterium (GO:0016045)6.23006672
6response to peptidoglycan (GO:0032494)5.87686559
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.79861180
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.79861180
9modulation by symbiont of host immune response (GO:0052553)5.79861180
10positive regulation by symbiont of host defense response (GO:0052509)5.79861180
11modulation by symbiont of host defense response (GO:0052031)5.79861180
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.79861180
13positive regulation of gamma-delta T cell activation (GO:0046645)5.41973094
14detection of external biotic stimulus (GO:0098581)5.34673260
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.30728760
16negative regulation of cell killing (GO:0031342)5.30728760
17cellular extravasation (GO:0045123)5.12727046
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.02272891
19neutrophil activation (GO:0042119)4.95603143
20macrophage activation involved in immune response (GO:0002281)4.85851601
21detection of biotic stimulus (GO:0009595)4.75042288
22detection of molecule of bacterial origin (GO:0032490)4.74664023
23respiratory burst (GO:0045730)4.70770775
24* defense response to fungus (GO:0050832)4.63034997
25granulocyte activation (GO:0036230)4.45620267
26production of molecular mediator involved in inflammatory response (GO:0002532)4.45117538
27negative regulation of interleukin-12 production (GO:0032695)4.40203832
28regulation of B cell receptor signaling pathway (GO:0050855)4.38766661
29microglial cell activation (GO:0001774)4.37943932
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.34874844
31response to host immune response (GO:0052572)4.34874844
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.34680063
33regulation of mast cell degranulation (GO:0043304)4.28867173
34immunoglobulin mediated immune response (GO:0016064)4.14087654
35antigen processing and presentation of endogenous antigen (GO:0019883)4.13985444
36regulation of myeloid leukocyte mediated immunity (GO:0002886)4.09404142
37regulation of interferon-beta biosynthetic process (GO:0045357)4.06752894
38negative regulation of lymphocyte mediated immunity (GO:0002707)4.01220238
39macrophage activation (GO:0042116)3.98558214
40response to host (GO:0075136)3.97336970
41response to host defenses (GO:0052200)3.97336970
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.97336970
43regulation of mast cell activation involved in immune response (GO:0033006)3.97239698
44* response to fungus (GO:0009620)3.96393144
45neutrophil mediated immunity (GO:0002446)3.90394675
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90352207
47myeloid cell activation involved in immune response (GO:0002275)3.89472940
48positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.85785867
49regulation of gamma-delta T cell activation (GO:0046643)3.81981488
50positive regulation of mast cell activation (GO:0033005)3.79918477
51regulation of leukocyte degranulation (GO:0043300)3.78151926
52regulation of mast cell activation (GO:0033003)3.71432769
53chronic inflammatory response (GO:0002544)3.63971591
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.58504222
55positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.57599645
56sequestering of metal ion (GO:0051238)3.55375133
57negative regulation of leukocyte mediated immunity (GO:0002704)3.53992684
58leukocyte degranulation (GO:0043299)3.52667932
59positive regulation of mast cell activation involved in immune response (GO:0033008)3.51223144
60positive regulation of mast cell degranulation (GO:0043306)3.51223144
61myeloid leukocyte mediated immunity (GO:0002444)3.48368359
62* neutrophil chemotaxis (GO:0030593)3.47395643
63antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.45520112
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.39976609
65regulation of regulated secretory pathway (GO:1903305)3.39505851
66* neutrophil migration (GO:1990266)3.38476418
67positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.31483068
68negative regulation of T cell mediated immunity (GO:0002710)3.31323160
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.28948632
70superoxide anion generation (GO:0042554)3.27181815
71B cell mediated immunity (GO:0019724)3.26480499
72response to muramyl dipeptide (GO:0032495)3.24831991
73negative regulation of interleukin-6 production (GO:0032715)3.23882338
74antigen processing and presentation via MHC class Ib (GO:0002475)3.20892675
75B cell receptor signaling pathway (GO:0050853)3.20247862
76regulation of gamma-delta T cell differentiation (GO:0045586)3.19972127
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.16042871
78negative regulation of erythrocyte differentiation (GO:0045647)3.15084678
79regulation of interleukin-8 biosynthetic process (GO:0045414)3.11032771
80defense response to protozoan (GO:0042832)3.08300408
81lipopolysaccharide-mediated signaling pathway (GO:0031663)3.07964967
82regulation of tolerance induction (GO:0002643)3.06734226
83negative regulation of T-helper cell differentiation (GO:0045623)3.05025056
84negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.05025056
85regulation of T-helper 2 cell differentiation (GO:0045628)3.04023306
86regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.99714175
87positive regulation of cellular amide metabolic process (GO:0034250)2.99409188
88response to interleukin-15 (GO:0070672)2.99158462
89positive regulation of B cell differentiation (GO:0045579)2.96984908
90regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.94346550
91disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.94195086
92killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.94195086
93germinal center formation (GO:0002467)2.94112244
94activated T cell proliferation (GO:0050798)2.93737217
95negative regulation of phagocytosis (GO:0050765)2.93572943
96regulation of B cell differentiation (GO:0045577)2.92911477
97negative regulation of B cell mediated immunity (GO:0002713)2.91511391
98negative regulation of immunoglobulin mediated immune response (GO:0002890)2.91511391
99* myeloid leukocyte activation (GO:0002274)2.91375364
100negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.88581972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.88950167
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.46074790
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.30992436
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.08393123
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.54445994
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.42105339
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.29136094
8MYB_21317192_ChIP-Seq_ERMYB_Mouse3.28079604
9SPI1_23547873_ChIP-Seq_NB4_Human3.11895023
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06225428
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.05221833
12VDR_24763502_ChIP-Seq_THP-1_Human2.95033331
13VDR_21846776_ChIP-Seq_THP-1_Human2.92887246
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.77907272
15SPI1_23127762_ChIP-Seq_K562_Human2.72850097
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65349747
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.59757126
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.55529463
19SCL_19346495_ChIP-Seq_HPC-7_Human2.53053240
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50709118
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.50264780
22RUNX_20019798_ChIP-Seq_JUKART_Human2.47852853
23RUNX1_22412390_ChIP-Seq_EML_Mouse2.38979669
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.38522002
25MAF_26560356_Chip-Seq_TH1_Human2.27599030
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22945397
27MYB_26560356_Chip-Seq_TH2_Human2.20580902
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.17682434
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16231664
30UTX_26944678_Chip-Seq_JUKART_Human2.08955621
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08144778
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03632537
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.97681641
34VDR_24787735_ChIP-Seq_THP-1_Human1.96626315
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96456243
36MYB_26560356_Chip-Seq_TH1_Human1.88600570
37TCF7_22412390_ChIP-Seq_EML_Mouse1.87816626
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84878444
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.79619688
40MYC_22102868_ChIP-Seq_BL_Human1.78280989
41GATA1_19941827_ChIP-Seq_MEL_Mouse1.74303003
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74019831
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69080635
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68494692
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.64487419
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63748112
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61256546
48PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59390981
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.57318605
50MAF_26560356_Chip-Seq_TH2_Human1.54999528
51GATA1_19941826_ChIP-Seq_K562_Human1.53546586
52GATA1_22025678_ChIP-Seq_K562_Human1.53110555
53GATA3_27048872_Chip-Seq_THYMUS_Human1.52575173
54KDM2B_26808549_Chip-Seq_DND41_Human1.52526660
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46776503
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46243816
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45020110
58PU_27001747_Chip-Seq_BMDM_Mouse1.44487250
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43977098
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43937946
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43735983
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43130869
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41987426
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40234988
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39666345
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38285036
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38113614
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36216761
69SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35867326
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34805499
71GATA3_26560356_Chip-Seq_TH2_Human1.34545688
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31213551
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29006756
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28993602
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28781817
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21442515
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20812587
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17726037
79GATA2_19941826_ChIP-Seq_K562_Human1.16943866
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13940319
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.11696950
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07891753
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07620310
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07513288
85BCL6_27268052_Chip-Seq_Bcells_Human1.05349403
86LXR_22292898_ChIP-Seq_THP-1_Human1.05141781
87BCOR_27268052_Chip-Seq_Bcells_Human1.05070999
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04968006
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00842402
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.00568644
91SPI1_20517297_ChIP-Seq_HL60_Human0.99729266
92VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96393889
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96356245
94KDM2B_26808549_Chip-Seq_JURKAT_Human0.96020807
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95827060
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92493890
97NCOR1_26117541_ChIP-Seq_K562_Human0.90007153
98GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81040893
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75695876
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74408358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.26940028
2MP0003436_decreased_susceptibility_to4.18054991
3MP0003303_peritoneal_inflammation3.89056908
4MP0001835_abnormal_antigen_presentation3.63869383
5MP0002419_abnormal_innate_immunity3.52368120
6MP0009785_altered_susceptibility_to3.49487081
7MP0005025_abnormal_response_to3.13927038
8MP0005000_abnormal_immune_tolerance2.78197667
9MP0000685_abnormal_immune_system2.70295285
10MP0001800_abnormal_humoral_immune2.69414850
11MP0005387_immune_system_phenotype2.67527865
12MP0001790_abnormal_immune_system2.67527865
13MP0005671_abnormal_response_to2.60115529
14MP0002723_abnormal_immune_serum2.51305904
15MP0002420_abnormal_adaptive_immunity2.50789823
16MP0001819_abnormal_immune_cell2.47942261
17MP0006082_CNS_inflammation2.47440322
18MP0002452_abnormal_antigen_presenting2.46453811
19MP0003191_abnormal_cellular_cholesterol2.42588439
20MP0005464_abnormal_platelet_physiology2.38597275
21MP0008260_abnormal_autophagy2.38301036
22MP0002148_abnormal_hypersensitivity_rea2.31533073
23MP0001533_abnormal_skeleton_physiology2.20959785
24MP0009278_abnormal_bone_marrow2.10369655
25MP0003300_gastrointestinal_ulcer2.08806488
26MP0003828_pulmonary_edema2.02386658
27MP0003172_abnormal_lysosome_physiology1.96934751
28MP0002405_respiratory_system_inflammati1.89862231
29MP0001845_abnormal_inflammatory_respons1.88346500
30MP0002132_abnormal_respiratory_system1.88339813
31MP0002398_abnormal_bone_marrow1.87214132
32MP0000716_abnormal_immune_system1.82779859
33MP0000465_gastrointestinal_hemorrhage1.77777040
34MP0005397_hematopoietic_system_phenotyp1.73060613
35MP0001545_abnormal_hematopoietic_system1.73060613
36MP0004947_skin_inflammation1.64327587
37MP0010155_abnormal_intestine_physiology1.59718189
38MP0003183_abnormal_peptide_metabolism1.59677566
39MP0003763_abnormal_thymus_physiology1.57785079
40MP0002722_abnormal_immune_system1.56366017
41MP0000689_abnormal_spleen_morphology1.55422567
42MP0003656_abnormal_erythrocyte_physiolo1.50799695
43MP0009764_decreased_sensitivity_to1.48232214
44MP0002429_abnormal_blood_cell1.47858760
45MP0004883_abnormal_blood_vessel1.47685265
46MP0008469_abnormal_protein_level1.47227857
47MP0003075_altered_response_to1.45723528
48MP0001851_eye_inflammation1.45505923
49MP0003806_abnormal_nucleotide_metabolis1.39950806
50MP0002396_abnormal_hematopoietic_system1.39668528
51MP0000858_altered_metastatic_potential1.38951087
52MP0003866_abnormal_defecation1.34095643
53MP0009333_abnormal_splenocyte_physiolog1.31773832
54MP0002277_abnormal_respiratory_mucosa1.31601311
55MP0005058_abnormal_lysosome_morphology1.27765450
56MP0005451_abnormal_body_composition1.25408743
57MP0004381_abnormal_hair_follicle1.24872828
58MP0000703_abnormal_thymus_morphology1.23657961
59MP0005164_abnormal_response_to1.21111985
60MP0002998_abnormal_bone_remodeling1.20657027
61MP0004510_myositis1.17681474
62MP0002166_altered_tumor_susceptibility1.12364472
63MP0005310_abnormal_salivary_gland1.12115403
64MP0000343_altered_response_to1.09657333
65MP0003690_abnormal_glial_cell1.08050091
66MP0005166_decreased_susceptibility_to1.00244428
67MP0005083_abnormal_biliary_tract0.98964765
68MP0008004_abnormal_stomach_pH0.96178768
69MP0009763_increased_sensitivity_to0.88881518
70MP0005390_skeleton_phenotype0.84677843
71MP0002138_abnormal_hepatobiliary_system0.84667378
72MP0003448_altered_tumor_morphology0.83657107
73MP0000569_abnormal_digit_pigmentation0.83380385
74MP0001853_heart_inflammation0.82202979
75MP0001663_abnormal_digestive_system0.79237549
76MP0004808_abnormal_hematopoietic_stem0.76940597
77MP0000015_abnormal_ear_pigmentation0.76484574
78MP0003045_fibrosis0.74735165
79MP0005075_abnormal_melanosome_morpholog0.73343406
80MP0003221_abnormal_cardiomyocyte_apopto0.73243667
81MP0001986_abnormal_taste_sensitivity0.71406762
82MP0003795_abnormal_bone_structure0.71046552
83MP0009765_abnormal_xenobiotic_induced0.68909050
84MP0002006_tumorigenesis0.68017535
85MP0005076_abnormal_cell_differentiation0.67225929
86MP0000604_amyloidosis0.66478205
87MP0005319_abnormal_enzyme/_coenzyme0.65813171
88MP0008874_decreased_physiological_sensi0.64368012
89MP0000249_abnormal_blood_vessel0.62049755
90MP0003566_abnormal_cell_adhesion0.58783192
91MP0004130_abnormal_muscle_cell0.56870967
92MP0000490_abnormal_crypts_of0.56202219
93MP0004264_abnormal_extraembryonic_tissu0.56022351
94MP0005388_respiratory_system_phenotype0.54020807
95MP0002133_abnormal_respiratory_system0.54020807
96MP0005376_homeostasis/metabolism_phenot0.53696521
97MP0001958_emphysema0.52317928
98MP0002332_abnormal_exercise_endurance0.51458142
99MP0004484_altered_response_of0.50975195
100MP0003091_abnormal_cell_migration0.50944828

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.27596344
2Recurrent abscess formation (HP:0002722)6.83573738
3Recurrent bacterial skin infections (HP:0005406)6.67870362
4Abnormality of macrophages (HP:0004311)5.99117721
5Recurrent gram-negative bacterial infections (HP:0005420)5.77069152
6Myositis (HP:0100614)5.44095970
7Stomatitis (HP:0010280)5.19529632
8Orchitis (HP:0100796)4.92247491
9Optic neuritis (HP:0100653)4.68531709
10Retrobulbar optic neuritis (HP:0100654)4.68531709
11Chronic obstructive pulmonary disease (HP:0006510)4.45439612
12Obstructive lung disease (HP:0006536)4.45439612
13Mediastinal lymphadenopathy (HP:0100721)4.33547426
14Gastrointestinal infarctions (HP:0005244)4.29701791
15Hypochromic microcytic anemia (HP:0004840)4.25060772
16Elevated erythrocyte sedimentation rate (HP:0003565)4.20977555
17Recurrent skin infections (HP:0001581)4.19924619
18Recurrent fungal infections (HP:0002841)4.10371732
19Gingivitis (HP:0000230)4.01115163
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.95189619
21Meningitis (HP:0001287)3.94781566
22Urticaria (HP:0001025)3.85860776
23Prolonged bleeding time (HP:0003010)3.84596212
24Keratoconjunctivitis sicca (HP:0001097)3.64485959
25Recurrent cutaneous fungal infections (HP:0011370)3.46419852
26Chronic mucocutaneous candidiasis (HP:0002728)3.46419852
27Hypochromic anemia (HP:0001931)3.42382167
28Encephalitis (HP:0002383)3.38445354
29Episodic fever (HP:0001954)3.38004946
30Keratoconjunctivitis (HP:0001096)3.34550618
31Cellulitis (HP:0100658)3.33050715
32Increased IgE level (HP:0003212)3.30637777
33Gingival bleeding (HP:0000225)3.28400591
34Spontaneous hematomas (HP:0007420)3.25814104
35Vasculitis (HP:0002633)3.17839414
36Epistaxis (HP:0000421)3.10268517
37Petechiae (HP:0000967)3.10108871
38Anorexia (HP:0002039)3.03805835
39Abnormality of the heme biosynthetic pathway (HP:0010472)3.02249975
40Peritonitis (HP:0002586)2.99603878
41Chest pain (HP:0100749)2.93941453
42Amyloidosis (HP:0011034)2.88940950
43Osteomyelitis (HP:0002754)2.85758649
44Hemoptysis (HP:0002105)2.85506068
45Pulmonary infiltrates (HP:0002113)2.79979888
46Leukocytosis (HP:0001974)2.77603686
47Arterial thrombosis (HP:0004420)2.70339670
48Microcytic anemia (HP:0001935)2.64327164
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.58397587
50Recurrent viral infections (HP:0004429)2.55616848
51Inflammation of the large intestine (HP:0002037)2.53172961
52Difficulty running (HP:0009046)2.51768335
53Metaphyseal cupping (HP:0003021)2.48449543
54Abnormal platelet volume (HP:0011876)2.46654411
55Pustule (HP:0200039)2.44885923
56T lymphocytopenia (HP:0005403)2.44156967
57Granulocytopenia (HP:0001913)2.42497877
58Sepsis (HP:0100806)2.42144258
59Gastrointestinal inflammation (HP:0004386)2.42068231
60Abnormality of T cell number (HP:0011839)2.41796035
61Pulmonary embolism (HP:0002204)2.37518160
62Abnormality of iron homeostasis (HP:0011031)2.33777681
63Gangrene (HP:0100758)2.33549259
64Purpura (HP:0000979)2.33293603
65Increased IgM level (HP:0003496)2.31081331
66Premature loss of primary teeth (HP:0006323)2.30133798
67Hepatosplenomegaly (HP:0001433)2.28940471
68Abnormality of T cells (HP:0002843)2.28463032
69Increased serum ferritin (HP:0003281)2.27325034
70Panhypogammaglobulinemia (HP:0003139)2.26251064
71Increased cerebral lipofuscin (HP:0011813)2.23893313
72Polycythemia (HP:0001901)2.20929156
73Abnormality of the peritoneum (HP:0002585)2.15295292
74Muscle fiber splitting (HP:0003555)2.15164153
75Colitis (HP:0002583)2.14406267
76Abnormality of the pleura (HP:0002103)2.14276533
77Abnormality of T cell physiology (HP:0011840)2.13126199
78Skin ulcer (HP:0200042)2.10169263
79Hypergammaglobulinemia (HP:0010702)2.09745257
80Recurrent pneumonia (HP:0006532)2.02791932
81Abnormality of glycolipid metabolism (HP:0010969)1.98736952
82Abnormality of liposaccharide metabolism (HP:0010968)1.98736952
83Abnormality of glycosphingolipid metabolism (HP:0004343)1.98736952
84Vertigo (HP:0002321)1.97327504
85Lymphopenia (HP:0001888)1.94728097
86Abnormality of the endocardium (HP:0004306)1.94188484
87Eosinophilia (HP:0001880)1.92324949
88Systemic lupus erythematosus (HP:0002725)1.89631480
89Glomerulopathy (HP:0100820)1.89154460
90Abnormality of transition element cation homeostasis (HP:0011030)1.89128629
91Skin rash (HP:0000988)1.87691344
92Slow saccadic eye movements (HP:0000514)1.87160744
93Increased neuronal autofluorescent lipopigment (HP:0002074)1.86987230
94Abnormality of cells of the lymphoid lineage (HP:0012140)1.86277039
95Menorrhagia (HP:0000132)1.83797306
96Toxemia of pregnancy (HP:0100603)1.83279027
97Acne (HP:0001061)1.82525807
98Disinhibition (HP:0000734)1.80710651
99Loss of speech (HP:0002371)1.80272567
100Keratitis (HP:0000491)1.80131595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.49896986
2MAP2K33.94565756
3IRAK43.39203276
4BLK3.12353004
5GRK62.88283806
6CSK2.83161511
7FES2.79965035
8MAP4K12.78987373
9TYK22.41916896
10ERN12.40343757
11TNK22.32462844
12FGR2.29399565
13ZAP702.16027821
14TAOK12.06180313
15PRPF4B2.04251952
16BTK2.01697681
17MAP3K31.97114344
18MAP3K61.93632157
19EPHB11.78074675
20SYK1.77309693
21HCK1.73936533
22JAK31.68195552
23MAP3K111.64408188
24MAP3K141.50744465
25LYN1.49122649
26JAK21.43101222
27TEC1.41286375
28YES11.38161069
29TXK1.37575978
30IKBKE1.32713029
31MAP3K11.29451713
32CSF1R1.20231595
33KSR21.19862980
34MAP3K131.14999284
35TBK11.14749764
36SIK31.14420221
37JAK11.10382807
38ITK1.09650078
39TAOK21.06173942
40LCK1.06084600
41MARK31.03840471
42KIT1.03038073
43MAP2K41.02758286
44IRAK11.00826518
45BMPR20.99126408
46MARK20.97338494
47IRAK20.92670940
48MATK0.90280004
49MAP3K50.88028105
50MAP3K20.85288770
51TAOK30.85040565
52PTK60.83906791
53PDK10.83171105
54PTK2B0.82487724
55PIK3CG0.82262818
56PDPK10.80400432
57CDK190.79213141
58LRRK20.78886575
59PRKD20.76751753
60STK100.74770483
61IKBKB0.74012796
62TESK20.73212336
63FYN0.73051303
64MAP2K60.67602695
65SIK20.61682501
66TGFBR20.58698320
67RET0.58478582
68MAP3K70.57642930
69STK110.56669899
70MAPK120.56642567
71SGK30.53443452
72DAPK20.52668930
73EPHA30.49581404
74RPS6KC10.48856634
75RPS6KL10.48856634
76RAF10.46903229
77FGFR30.45903817
78KSR10.44755549
79TRIB30.40829003
80PIM10.40786493
81MAPK70.40708532
82MAPKAPK20.40553411
83RPS6KA60.40258346
84DYRK1B0.39894268
85CDC42BPA0.38609081
86PRKCQ0.37889196
87BMX0.36121893
88PRKCD0.35838610
89SGK20.34390305
90HIPK20.34105635
91SMG10.33898135
92CLK10.30971803
93PRKCZ0.29517031
94WNK10.28962056
95ABL10.28240898
96DYRK30.27340682
97MOS0.27167828
98PRKG20.25777316
99GRK70.25776596
100STK380.25703159

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.29354113
2Leishmaniasis_Homo sapiens_hsa051403.24373872
3Osteoclast differentiation_Homo sapiens_hsa043803.20005337
4Staphylococcus aureus infection_Homo sapiens_hsa051502.92898600
5Tuberculosis_Homo sapiens_hsa051522.28382698
6Malaria_Homo sapiens_hsa051442.18636796
7B cell receptor signaling pathway_Homo sapiens_hsa046622.18490191
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.17511260
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.17450967
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.04476858
11Legionellosis_Homo sapiens_hsa051342.03780982
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.00432240
13Hematopoietic cell lineage_Homo sapiens_hsa046401.82662273
14Graft-versus-host disease_Homo sapiens_hsa053321.75344089
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69393606
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67510917
17Allograft rejection_Homo sapiens_hsa053301.67023453
18Chemokine signaling pathway_Homo sapiens_hsa040621.61542892
19Autoimmune thyroid disease_Homo sapiens_hsa053201.54831855
20Acute myeloid leukemia_Homo sapiens_hsa052211.54249834
21Measles_Homo sapiens_hsa051621.53341794
22Phagosome_Homo sapiens_hsa041451.48176760
23Primary immunodeficiency_Homo sapiens_hsa053401.47480726
24Toxoplasmosis_Homo sapiens_hsa051451.45294773
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.40478045
26Asthma_Homo sapiens_hsa053101.39520045
27Influenza A_Homo sapiens_hsa051641.38640299
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.34078010
29T cell receptor signaling pathway_Homo sapiens_hsa046601.30138318
30African trypanosomiasis_Homo sapiens_hsa051431.29833001
31Platelet activation_Homo sapiens_hsa046111.29536085
32Salmonella infection_Homo sapiens_hsa051321.25056948
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23992394
34Pertussis_Homo sapiens_hsa051331.21738540
35Type I diabetes mellitus_Homo sapiens_hsa049401.21291553
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20978293
37Antigen processing and presentation_Homo sapiens_hsa046121.19433664
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.19259065
39TNF signaling pathway_Homo sapiens_hsa046681.16583720
40Non-small cell lung cancer_Homo sapiens_hsa052231.13953749
41Other glycan degradation_Homo sapiens_hsa005111.13037215
42Herpes simplex infection_Homo sapiens_hsa051681.11727193
43Viral myocarditis_Homo sapiens_hsa054161.11628709
44Shigellosis_Homo sapiens_hsa051311.10700210
45Hepatitis B_Homo sapiens_hsa051611.04218742
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01332390
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.96353433
48Pancreatic cancer_Homo sapiens_hsa052120.95163656
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94172920
50Rheumatoid arthritis_Homo sapiens_hsa053230.93712758
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93041136
52Hepatitis C_Homo sapiens_hsa051600.91448559
53Amoebiasis_Homo sapiens_hsa051460.86391772
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86367991
55Chronic myeloid leukemia_Homo sapiens_hsa052200.84642508
56VEGF signaling pathway_Homo sapiens_hsa043700.84231488
57Lysosome_Homo sapiens_hsa041420.80153751
58Apoptosis_Homo sapiens_hsa042100.79614031
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77282768
60Renal cell carcinoma_Homo sapiens_hsa052110.76902422
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.76774919
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75168809
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73804776
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73618922
65Endocytosis_Homo sapiens_hsa041440.73458654
66Prolactin signaling pathway_Homo sapiens_hsa049170.72927678
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71826625
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71720792
69Type II diabetes mellitus_Homo sapiens_hsa049300.70213399
70HIF-1 signaling pathway_Homo sapiens_hsa040660.69958078
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.69178168
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67195618
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.66642958
74FoxO signaling pathway_Homo sapiens_hsa040680.63811629
75GnRH signaling pathway_Homo sapiens_hsa049120.62318277
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.59408733
77Galactose metabolism_Homo sapiens_hsa000520.58689728
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58174570
79Notch signaling pathway_Homo sapiens_hsa043300.56076865
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55706051
81Regulation of autophagy_Homo sapiens_hsa041400.55465159
82Choline metabolism in cancer_Homo sapiens_hsa052310.53858759
83Viral carcinogenesis_Homo sapiens_hsa052030.53688619
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.52840629
85Collecting duct acid secretion_Homo sapiens_hsa049660.52036027
86Endometrial cancer_Homo sapiens_hsa052130.52031959
87Dorso-ventral axis formation_Homo sapiens_hsa043200.51714107
88Epstein-Barr virus infection_Homo sapiens_hsa051690.51504397
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49327699
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44972889
91Rap1 signaling pathway_Homo sapiens_hsa040150.43966397
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.42915893
93Insulin resistance_Homo sapiens_hsa049310.42686751
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42294349
95Inositol phosphate metabolism_Homo sapiens_hsa005620.41789560
96MAPK signaling pathway_Homo sapiens_hsa040100.41320559
97mTOR signaling pathway_Homo sapiens_hsa041500.40560949
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38910624
99Insulin signaling pathway_Homo sapiens_hsa049100.38731999
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38199196

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