S100A10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)7.15663337
2viral transcription (GO:0019083)6.63068305
3translational termination (GO:0006415)6.28832027
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.45516801
5translational elongation (GO:0006414)5.39170554
6protein targeting to ER (GO:0045047)5.33867427
7cotranslational protein targeting to membrane (GO:0006613)5.32389182
8ribosomal small subunit biogenesis (GO:0042274)5.31399659
9ribosomal small subunit assembly (GO:0000028)5.19683133
10viral life cycle (GO:0019058)5.16444459
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.06797796
12protein localization to endoplasmic reticulum (GO:0070972)5.06604364
13cellular protein complex disassembly (GO:0043624)5.03311850
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.46081072
15hemidesmosome assembly (GO:0031581)4.41208646
16response to water (GO:0009415)4.39729622
17translational initiation (GO:0006413)4.27973624
18proteasome assembly (GO:0043248)4.24484664
19protein maturation by protein folding (GO:0022417)4.14593579
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.09197701
21regulation of metalloenzyme activity (GO:0048552)4.05552662
22protein complex disassembly (GO:0043241)4.05390208
23ribosomal large subunit biogenesis (GO:0042273)3.93133364
24protein targeting to membrane (GO:0006612)3.86972560
25macromolecular complex disassembly (GO:0032984)3.80754869
26COPI coating of Golgi vesicle (GO:0048205)3.68901750
27Golgi transport vesicle coating (GO:0048200)3.68901750
28protein retention in ER lumen (GO:0006621)3.58062364
29maturation of SSU-rRNA (GO:0030490)3.57872575
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.50027828
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.46196683
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46196683
33skin morphogenesis (GO:0043589)3.40586784
34bundle of His cell to Purkinje myocyte communication (GO:0086069)3.34376397
35Arp2/3 complex-mediated actin nucleation (GO:0034314)3.33839743
36barbed-end actin filament capping (GO:0051016)3.27066538
37translation (GO:0006412)3.10914552
38regulation of apoptotic process involved in morphogenesis (GO:1902337)3.10313747
39cellular response to nicotine (GO:0071316)3.01279601
40antigen processing and presentation of endogenous antigen (GO:0019883)3.01239013
41positive regulation of Cdc42 GTPase activity (GO:0043089)2.97796640
42cellular response to zinc ion (GO:0071294)2.96354895
43pinocytosis (GO:0006907)2.94288658
44regulation of protein heterodimerization activity (GO:0043497)2.93138354
45pyrimidine nucleoside salvage (GO:0043097)2.92840991
46pyrimidine-containing compound salvage (GO:0008655)2.92840991
47neutrophil activation involved in immune response (GO:0002283)2.87528038
48actin nucleation (GO:0045010)2.86362111
49cellular copper ion homeostasis (GO:0006878)2.85342519
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84413797
51protein neddylation (GO:0045116)2.81769517
52antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.81257713
53GDP-mannose metabolic process (GO:0019673)2.81144411
54positive regulation of epidermal cell differentiation (GO:0045606)2.80806380
55cytidine deamination (GO:0009972)2.79578261
56cytidine metabolic process (GO:0046087)2.79578261
57cytidine catabolic process (GO:0006216)2.79578261
58positive regulation of actin filament depolymerization (GO:0030836)2.77461108
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.76402836
60extracellular fibril organization (GO:0043206)2.75678229
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75564805
62desmosome organization (GO:0002934)2.72086710
63nucleoside salvage (GO:0043174)2.71735163
64negative regulation of ligase activity (GO:0051352)2.71651047
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71651047
66positive regulation of epidermis development (GO:0045684)2.71180408
67positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.71076974
68negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.69829592
69nuclear-transcribed mRNA catabolic process (GO:0000956)2.69070773
70regulation of water loss via skin (GO:0033561)2.68271783
71fibril organization (GO:0097435)2.66762511
72signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.65578374
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65578374
74cell adhesion mediated by integrin (GO:0033627)2.65199139
75aldehyde catabolic process (GO:0046185)2.65144811
76* establishment of protein localization to membrane (GO:0090150)2.64792802
77regulation of monocyte chemotaxis (GO:0090025)2.63787580
78regulation of transforming growth factor beta2 production (GO:0032909)2.63116782
79protein localization to endosome (GO:0036010)2.61562321
80phospholipid scrambling (GO:0017121)2.61320870
81positive regulation of natural killer cell differentiation (GO:0032825)2.61255430
82response to interferon-beta (GO:0035456)2.60292641
83type B pancreatic cell proliferation (GO:0044342)2.58931664
84nucleotide-sugar biosynthetic process (GO:0009226)2.58419635
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.56958158
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.56958158
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.56958158
88nucleobase-containing small molecule interconversion (GO:0015949)2.56819892
89regulation of histone phosphorylation (GO:0033127)2.56616081
90cyclooxygenase pathway (GO:0019371)2.55597920
91phenol-containing compound catabolic process (GO:0019336)2.54701946
92negative regulation of protein autophosphorylation (GO:0031953)2.54496516
93galactose metabolic process (GO:0006012)2.54197022
94mRNA catabolic process (GO:0006402)2.53721973
95negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.50599816
96signal transduction involved in DNA damage checkpoint (GO:0072422)2.48191477
97signal transduction involved in DNA integrity checkpoint (GO:0072401)2.48191477
98regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47526230
99negative regulation of nitric oxide biosynthetic process (GO:0045019)2.46606043
100cellular response to type I interferon (GO:0071357)2.46384443
101type I interferon signaling pathway (GO:0060337)2.46384443
102response to type I interferon (GO:0034340)2.45710536
103keratan sulfate catabolic process (GO:0042340)2.45034637
104glycosphingolipid catabolic process (GO:0046479)2.43503839
105galactose catabolic process (GO:0019388)2.42908474
106regulation of interleukin-8 secretion (GO:2000482)2.39925529
107signal transduction involved in cell cycle checkpoint (GO:0072395)2.37650711
108regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.37650640
109negative regulation of nitric-oxide synthase activity (GO:0051001)2.37231116
110regulation of cellular amine metabolic process (GO:0033238)2.37167810
111anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.36913177
112surfactant homeostasis (GO:0043129)2.36113985
113activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.34354482
114deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.34249209
115response to peptidoglycan (GO:0032494)2.33564137
116regulation of necrotic cell death (GO:0010939)2.33425958
117regulation of integrin-mediated signaling pathway (GO:2001044)2.33174850
118T cell apoptotic process (GO:0070231)2.33040331
119actin filament depolymerization (GO:0030042)2.31662674
120dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.31423365
121mitotic nuclear envelope reassembly (GO:0007084)2.31377592
122nuclear envelope reassembly (GO:0031468)2.31377592
123cellular response to interferon-alpha (GO:0035457)2.30688311
124positive regulation of extracellular matrix organization (GO:1903055)2.30060633
125protein targeting (GO:0006605)2.29867186
126positive regulation of reactive oxygen species metabolic process (GO:2000379)2.29807330
127hepatocyte apoptotic process (GO:0097284)2.28538445
128antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.28524577
129positive regulation of monocyte chemotaxis (GO:0090026)2.28202751
130regulation of podosome assembly (GO:0071801)2.27712527
131response to copper ion (GO:0046688)2.26857088
132peptidyl-proline hydroxylation (GO:0019511)2.26699868
133positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.26687537
134regulation of cytokine secretion involved in immune response (GO:0002739)2.26528008
135negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.24897004
136positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.24386095
137cell-substrate junction assembly (GO:0007044)2.24321482
138detection of temperature stimulus involved in sensory perception (GO:0050961)2.24299680
139detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.24299680
140response to interferon-alpha (GO:0035455)2.23706866
141ATP synthesis coupled proton transport (GO:0015986)2.22969924
142energy coupled proton transport, down electrochemical gradient (GO:0015985)2.22969924
143glycolipid catabolic process (GO:0019377)2.22919858
144positive regulation of macrophage differentiation (GO:0045651)2.22648317
145positive regulation of lamellipodium assembly (GO:0010592)2.22582391
146* membrane budding (GO:0006900)2.22476864
147response to progesterone (GO:0032570)2.22146385
148positive regulation of gamma-delta T cell activation (GO:0046645)2.22033466
149oligosaccharide catabolic process (GO:0009313)2.21843807
150regulation of cellular amino acid metabolic process (GO:0006521)2.21708105
151RNA catabolic process (GO:0006401)2.21636659
152platelet aggregation (GO:0070527)2.21273405
153regulation of superoxide anion generation (GO:0032928)2.21127791
154mitochondrial calcium ion transport (GO:0006851)2.20880965
155hydrogen peroxide catabolic process (GO:0042744)2.20261887
156aggressive behavior (GO:0002118)2.19668244
157copper ion homeostasis (GO:0055070)2.19550089
158regulation of extracellular matrix disassembly (GO:0010715)2.19531021
159negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.19525879
160protein hydroxylation (GO:0018126)2.18715366
161leukocyte aggregation (GO:0070486)2.18638144
162positive regulation of ligase activity (GO:0051351)2.17852784
163negative regulation of type 2 immune response (GO:0002829)2.16405172
164establishment of skin barrier (GO:0061436)2.15685294
165detection of temperature stimulus (GO:0016048)2.14994428
166positive regulation of keratinocyte differentiation (GO:0045618)2.14439069
167positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.14255784
168protein autoprocessing (GO:0016540)2.13663522
169mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.13628051
170negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.13101369
171* membrane raft organization (GO:0031579)2.12696600
172endodermal cell differentiation (GO:0035987)2.11717493
173regulation of natural killer cell differentiation (GO:0032823)2.10888845
174positive regulation of endothelial cell apoptotic process (GO:2000353)2.10836205
175positive regulation of hair cycle (GO:0042635)2.10566328
176positive regulation of hair follicle development (GO:0051798)2.10566328
177cellular response to interferon-beta (GO:0035458)2.10529575
178respiratory burst (GO:0045730)2.09781071
179DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.09643581
180positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.08338013
181T cell migration (GO:0072678)2.07210837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.65031431
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.59089170
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.17710959
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.17648978
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.96415793
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.70147712
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.69177111
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64527184
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.58437297
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.51449394
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37183135
12* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35688101
13* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34425176
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.28855210
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11326431
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.11295769
17ZNF263_19887448_ChIP-Seq_K562_Human2.02938565
18* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95708438
19* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94176471
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.90114278
21* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79497791
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.79393267
23* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.79018521
24HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.77208343
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.73410067
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.73267248
27* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.73254250
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72690672
29ELK1_22589737_ChIP-Seq_MCF10A_Human1.71179681
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68110251
31* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66105946
32KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.66082361
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65235750
34* ELK3_25401928_ChIP-Seq_HUVEC_Human1.63362529
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.60656967
36HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.56464289
37* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56436882
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.55867619
39* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53628653
40* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53628653
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53422209
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50562480
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50326809
44* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50137763
45SOX2_20726797_ChIP-Seq_SW620_Human1.47402571
46* MAF_26560356_Chip-Seq_TH1_Human1.46822166
47SPI1_23547873_ChIP-Seq_NB4_Human1.45684262
48* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45187601
49ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44848697
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44758117
51* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44639830
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43660183
53ELK1_19687146_ChIP-ChIP_HELA_Human1.42404558
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40007473
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.39124689
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38719325
57* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36814645
58* IRF8_27001747_Chip-Seq_BMDM_Mouse1.36760487
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.35908698
60JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35129084
61AR_21909140_ChIP-Seq_LNCAP_Human1.34678570
62* ATF3_27146783_Chip-Seq_COLON_Human1.34598376
63* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32836249
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31555974
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29689286
66P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29624870
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29104709
68CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.29083795
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29078295
70MYB_26560356_Chip-Seq_TH2_Human1.27456907
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26589540
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26150701
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.24572195
74VDR_24763502_ChIP-Seq_THP-1_Human1.23848048
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22483642
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22324820
77* GATA6_25053715_ChIP-Seq_YYC3_Human1.22093514
78* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21676759
79* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21621673
80MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20765864
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20319619
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20190391
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19809839
84* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19245307
85* RXR_22158963_ChIP-Seq_LIVER_Mouse1.18588143
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18176753
87CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18079339
88* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18030575
89XRN2_22483619_ChIP-Seq_HELA_Human1.17943084
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16955422
91EGR1_19032775_ChIP-ChIP_M12_Human1.16867462
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14446381
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13887540
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13662530
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13573146
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13523703
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12943865
98VDR_21846776_ChIP-Seq_THP-1_Human1.11774333
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11256794
100TFEB_21752829_ChIP-Seq_HELA_Human1.11202536
101ESR1_20079471_ChIP-ChIP_T-47D_Human1.10870600
102DCP1A_22483619_ChIP-Seq_HELA_Human1.10533939
103* GATA4_25053715_ChIP-Seq_YYC3_Human1.09652677
104* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08977231
105MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07410638
106* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07109114
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06846555
108EST1_17652178_ChIP-ChIP_JURKAT_Human1.06088194
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06064974
110* UBF1/2_26484160_Chip-Seq_HMECs_Human1.06036561
111* GATA3_24758297_ChIP-Seq_MCF-7_Human1.05554946
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05520438
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04700464
114* CLOCK_20551151_ChIP-Seq_293T_Human1.03845065
115ELF5_23300383_ChIP-Seq_T47D_Human1.03614460
116UTX_26944678_Chip-Seq_JUKART_Human1.03510262
117ETS1_20019798_ChIP-Seq_JURKAT_Human1.03348856
118* MAF_26560356_Chip-Seq_TH2_Human1.01977876
119* CJUN_26792858_Chip-Seq_BT549_Human1.01708250
120JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01482834
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01414718
122* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01245676
123P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01023835
124* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00746386
125* RACK7_27058665_Chip-Seq_MCF-7_Human1.00459008
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99970285
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.98518598
128MYB_26560356_Chip-Seq_TH1_Human0.98016408
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.95393594
130LXR_22292898_ChIP-Seq_THP-1_Human0.94549976
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89875646
132* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89315303

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.14956768
2MP0005275_abnormal_skin_tensile2.93951473
3MP0003950_abnormal_plasma_membrane2.91970527
4MP0008438_abnormal_cutaneous_collagen2.89737764
5MP0003436_decreased_susceptibility_to2.86186842
6MP0001835_abnormal_antigen_presentation2.58902071
7MP0009785_altered_susceptibility_to2.47667735
8MP0003705_abnormal_hypodermis_morpholog2.41435896
9MP0002877_abnormal_melanocyte_morpholog2.35051561
10MP0003724_increased_susceptibility_to2.28461520
11MP0002148_abnormal_hypersensitivity_rea2.24565888
12MP0003566_abnormal_cell_adhesion2.19776265
13MP0005058_abnormal_lysosome_morphology2.16438973
14MP0005000_abnormal_immune_tolerance1.99020539
15MP0005671_abnormal_response_to1.97952666
16MP0002166_altered_tumor_susceptibility1.89690076
17MP0005025_abnormal_response_to1.87037015
18MP0005023_abnormal_wound_healing1.82827263
19MP0000685_abnormal_immune_system1.82808336
20MP0004947_skin_inflammation1.82643003
21MP0000858_altered_metastatic_potential1.81601550
22MP0010352_gastrointestinal_tract_polyps1.76328744
23MP0001533_abnormal_skeleton_physiology1.76162355
24MP0002006_tumorigenesis1.74316975
25MP0010155_abnormal_intestine_physiology1.71928220
26MP0002060_abnormal_skin_morphology1.69209644
27MP0000372_irregular_coat_pigmentation1.68103414
28MP0001853_heart_inflammation1.66402783
29MP0005503_abnormal_tendon_morphology1.65922272
30MP0004264_abnormal_extraembryonic_tissu1.63207053
31MP0005257_abnormal_intraocular_pressure1.62312418
32MP0008260_abnormal_autophagy1.57847768
33MP0002419_abnormal_innate_immunity1.57613384
34MP0003279_aneurysm1.57145747
35MP0001800_abnormal_humoral_immune1.56501476
36MP0005387_immune_system_phenotype1.56134718
37MP0001790_abnormal_immune_system1.56134718
38MP0002933_joint_inflammation1.55572004
39MP0002452_abnormal_antigen_presenting1.54205940
40MP0002796_impaired_skin_barrier1.54141997
41MP0003941_abnormal_skin_development1.53822746
42MP0001542_abnormal_bone_strength1.53491684
43MP0006082_CNS_inflammation1.52143262
44MP0002405_respiratory_system_inflammati1.51402184
45MP0005165_increased_susceptibility_to1.51315079
46MP0000762_abnormal_tongue_morphology1.50211875
47MP0002723_abnormal_immune_serum1.49706348
48MP0003186_abnormal_redox_activity1.49635190
49MP0009333_abnormal_splenocyte_physiolog1.47804613
50MP0003300_gastrointestinal_ulcer1.46699302
51MP0001819_abnormal_immune_cell1.45893204
52MP0002420_abnormal_adaptive_immunity1.45116915
53MP0005464_abnormal_platelet_physiology1.43024466
54MP0003866_abnormal_defecation1.41299936
55MP0001845_abnormal_inflammatory_respons1.41012148
56MP0000343_altered_response_to1.39908540
57MP0004858_abnormal_nervous_system1.36707622
58MP0010234_abnormal_vibrissa_follicle1.36203060
59MP0003075_altered_response_to1.35121697
60MP0003453_abnormal_keratinocyte_physiol1.33882028
61MP0003763_abnormal_thymus_physiology1.32994912
62MP0003828_pulmonary_edema1.32229013
63MP0000538_abnormal_urinary_bladder1.31923436
64MP0005166_decreased_susceptibility_to1.29321979
65MP0002132_abnormal_respiratory_system1.25380651
66MP0005451_abnormal_body_composition1.22924988
67MP0005390_skeleton_phenotype1.20435338
68MP0001243_abnormal_dermal_layer1.20434001
69MP0010678_abnormal_skin_adnexa1.18612888
70MP0000467_abnormal_esophagus_morphology1.17055888
71MP0000579_abnormal_nail_morphology1.16931139
72MP0002254_reproductive_system_inflammat1.16556911
73MP0009053_abnormal_anal_canal1.15917091
74MP0001216_abnormal_epidermal_layer1.14590422
75MP0003693_abnormal_embryo_hatching1.14457347
76MP0003448_altered_tumor_morphology1.13278010
77MP0005501_abnormal_skin_physiology1.12150982
78MP0010030_abnormal_orbit_morphology1.12043059
79MP0008469_abnormal_protein_level1.11164809
80MP0010386_abnormal_urinary_bladder1.08241146
81MP0005408_hypopigmentation1.06907368
82MP0003656_abnormal_erythrocyte_physiolo1.05907931
83MP0004272_abnormal_basement_membrane1.05595238
84MP0005360_urolithiasis1.04258894
85MP0000627_abnormal_mammary_gland1.02921668
86MP0005083_abnormal_biliary_tract1.02767844
87MP0002098_abnormal_vibrissa_morphology1.02096522
88MP0000490_abnormal_crypts_of1.01941701
89MP0009764_decreased_sensitivity_to1.01860555
90MP0000716_abnormal_immune_system1.01424093
91MP0002398_abnormal_bone_marrow1.00856919
92MP0001881_abnormal_mammary_gland1.00736439
93MP0001663_abnormal_digestive_system1.00509267
94MP0002282_abnormal_trachea_morphology0.99870729
95MP0002139_abnormal_hepatobiliary_system0.99635503
96MP0002998_abnormal_bone_remodeling0.98998264
97MP0000678_abnormal_parathyroid_gland0.98960500
98MP0004233_abnormal_muscle_weight0.98943986
99MP0001873_stomach_inflammation0.98843899
100MP0001348_abnormal_lacrimal_gland0.98241970
101MP0002735_abnormal_chemical_nociception0.98098147
102MP0005397_hematopoietic_system_phenotyp0.97951990
103MP0001545_abnormal_hematopoietic_system0.97951990
104MP0003091_abnormal_cell_migration0.95779276
105MP0010771_integument_phenotype0.95750069
106MP0003191_abnormal_cellular_cholesterol0.92568968
107MP0006054_spinal_hemorrhage0.92567454
108MP0000465_gastrointestinal_hemorrhage0.92542578
109MP0001849_ear_inflammation0.91860798
110MP0004782_abnormal_surfactant_physiolog0.91851139
111MP0008004_abnormal_stomach_pH0.91314674
112MP0002722_abnormal_immune_system0.90858762
113MP0003806_abnormal_nucleotide_metabolis0.90799102
114MP0005330_cardiomyopathy0.88504129
115MP0010368_abnormal_lymphatic_system0.88106957
116MP0000516_abnormal_urinary_system0.87998634
117MP0005367_renal/urinary_system_phenotyp0.87998634
118MP0002429_abnormal_blood_cell0.87929663
119MP0001958_emphysema0.87410392
120MP0009780_abnormal_chondrocyte_physiolo0.85936326
121MP0002138_abnormal_hepatobiliary_system0.85265138
122MP0003795_abnormal_bone_structure0.83281978
123MP0009931_abnormal_skin_appearance0.82730423
124MP0005164_abnormal_response_to0.82017062
125MP0003303_peritoneal_inflammation0.81711504
126MP0003045_fibrosis0.81383129
127MP0002896_abnormal_bone_mineralization0.80865973
128MP0004019_abnormal_vitamin_homeostasis0.80854328
129MP0002332_abnormal_exercise_endurance0.80130475
130MP0000689_abnormal_spleen_morphology0.80090278
131MP0004883_abnormal_blood_vessel0.79529376
132MP0000750_abnormal_muscle_regeneration0.79086757
133MP0000377_abnormal_hair_follicle0.78697544
134MP0000537_abnormal_urethra_morphology0.77983749
135MP0009840_abnormal_foam_cell0.77855133
136MP0008875_abnormal_xenobiotic_pharmacok0.76605813
137MP0005197_abnormal_uvea_morphology0.75998400
138MP0005670_abnormal_white_adipose0.74185730
139MP0002751_abnormal_autonomic_nervous0.74141823
140MP0001851_eye_inflammation0.74028883
141MP0000249_abnormal_blood_vessel0.73115108
142MP0000767_abnormal_smooth_muscle0.72074682

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)4.42583499
2Abnormality of cells of the erythroid lineage (HP:0012130)4.41222480
3Abnormality of glycolipid metabolism (HP:0010969)3.66719585
4Abnormality of liposaccharide metabolism (HP:0010968)3.66719585
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.66719585
6Elevated erythrocyte sedimentation rate (HP:0003565)3.58551144
7Right ventricular cardiomyopathy (HP:0011663)3.51996748
8Reduced subcutaneous adipose tissue (HP:0003758)3.38629855
9Amyloidosis (HP:0011034)3.37816521
10Protrusio acetabuli (HP:0003179)3.21568851
11Hypothermia (HP:0002045)3.19989499
12Vertebral compression fractures (HP:0002953)3.18909030
13Eczematoid dermatitis (HP:0000976)3.13087904
14Fragile nails (HP:0001808)3.12514822
15Distal lower limb muscle weakness (HP:0009053)3.06381108
16Abnormal number of erythroid precursors (HP:0012131)3.05360419
17Pallor (HP:0000980)2.92794932
18Atrophic scars (HP:0001075)2.91714122
19Myotonia (HP:0002486)2.87924480
20Pustule (HP:0200039)2.86703657
21Myositis (HP:0100614)2.85936683
22Osteolytic defects of the hand bones (HP:0009699)2.79650390
23Osteolytic defects of the phalanges of the hand (HP:0009771)2.79650390
24Vascular calcification (HP:0004934)2.77879477
25Trismus (HP:0000211)2.77584316
26Cardiovascular calcification (HP:0011915)2.71808094
27Glucose intolerance (HP:0000833)2.70226609
28Recurrent abscess formation (HP:0002722)2.69929315
29Macrocytic anemia (HP:0001972)2.68987064
30Premature rupture of membranes (HP:0001788)2.68825620
31Congenital ichthyosiform erythroderma (HP:0007431)2.64302563
32Reticulocytopenia (HP:0001896)2.63232985
33Peritonitis (HP:0002586)2.60022631
34Rough bone trabeculation (HP:0100670)2.51224106
35Alopecia of scalp (HP:0002293)2.47932903
36Beaking of vertebral bodies (HP:0004568)2.46655806
37Increased connective tissue (HP:0009025)2.41943254
38Thoracolumbar scoliosis (HP:0002944)2.39102693
39Nail dystrophy (HP:0008404)2.38846004
40Orchitis (HP:0100796)2.37675981
41Fragile skin (HP:0001030)2.36238408
42Recurrent bacterial skin infections (HP:0005406)2.34736519
43Plantar hyperkeratosis (HP:0007556)2.33301352
44Abnormality of placental membranes (HP:0011409)2.33199748
45Amniotic constriction ring (HP:0009775)2.33199748
46Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.33032183
47Onycholysis (HP:0001806)2.32608554
48Short nail (HP:0001799)2.29306384
49Milia (HP:0001056)2.26994655
50Hypokinesia (HP:0002375)2.22198903
51Dysostosis multiplex (HP:0000943)2.22051552
52Distal lower limb amyotrophy (HP:0008944)2.21847530
53Malnutrition (HP:0004395)2.19117508
54Spondylolisthesis (HP:0003302)2.18983267
55Cervical subluxation (HP:0003308)2.17438595
56Woolly hair (HP:0002224)2.13920615
57Vacuolated lymphocytes (HP:0001922)2.13395776
58Nuclear cataract (HP:0100018)2.13316490
59Ulnar claw (HP:0001178)2.13070030
60Myokymia (HP:0002411)2.10474245
61Micronodular cirrhosis (HP:0001413)2.09842154
62Abnormality of nail color (HP:0100643)2.09069343
63Mesangial abnormality (HP:0001966)2.06379170
64Abnormal trabecular bone morphology (HP:0100671)2.05998432
65Acanthosis nigricans (HP:0000956)2.04718806
66Biconcave vertebral bodies (HP:0004586)2.04698413
67Down-sloping shoulders (HP:0200021)2.04667151
68Interstitial pulmonary disease (HP:0006530)2.04552753
69Entropion (HP:0000621)2.02858629
70Cupped ribs (HP:0000887)2.02165626
71Prolonged neonatal jaundice (HP:0006579)2.01536952
72Petechiae (HP:0000967)2.01041306
73Vascular tortuosity (HP:0004948)2.00208879
74Thick nail (HP:0001805)2.00044813
75Abnormal blistering of the skin (HP:0008066)1.99391489
76Abnormal tarsal ossification (HP:0008369)1.99287668
77Pili torti (HP:0003777)1.99147717
78Palpitations (HP:0001962)1.99016009
79Hepatosplenomegaly (HP:0001433)1.98403366
80Progressive neurologic deterioration (HP:0002344)1.98155570
81Abnormalities of placenta or umbilical cord (HP:0001194)1.98153069
82Flat acetabular roof (HP:0003180)1.96159542
83Aortic dissection (HP:0002647)1.96075780
84Arterial tortuosity (HP:0005116)1.95987230
85Coxa vara (HP:0002812)1.94976030
86Axonal loss (HP:0003447)1.94938428
87Purpura (HP:0000979)1.94480191
88Nasal polyposis (HP:0100582)1.94208540
89Mitral stenosis (HP:0001718)1.93113237
90Spinal cord compression (HP:0002176)1.93088500
91Wormian bones (HP:0002645)1.92871196
92Anhidrosis (HP:0000970)1.90822409
93Loss of speech (HP:0002371)1.90705699
94Abnormality of the umbilical cord (HP:0010881)1.89717505
95Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89625427
96Abnormal hair laboratory examination (HP:0003328)1.89521136
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87822615
98Ankle contracture (HP:0006466)1.87069094
99Congenital, generalized hypertrichosis (HP:0004540)1.85446156
100Distal arthrogryposis (HP:0005684)1.85391815
101Abnormal foot bone ossification (HP:0010675)1.83998105
102Neonatal short-limb short stature (HP:0008921)1.83533260
103Abnormal glucose tolerance (HP:0001952)1.83207876
104Urinary glycosaminoglycan excretion (HP:0003541)1.82332911
105Mucopolysacchariduria (HP:0008155)1.82332911
106Abnormal platelet volume (HP:0011876)1.81564604
107Radial bowing (HP:0002986)1.81304993
108Irregular epiphyses (HP:0010582)1.81247808
109Conjunctival hamartoma (HP:0100780)1.81031868
110Abnormality of the distal phalanges of the toes (HP:0010182)1.80270597
111Increased mean platelet volume (HP:0011877)1.80130818
112Abnormal mitochondria in muscle tissue (HP:0008316)1.79561811
113Natal tooth (HP:0000695)1.79081974
114Systemic lupus erythematosus (HP:0002725)1.78996471
115Optic neuritis (HP:0100653)1.78866700
116Retrobulbar optic neuritis (HP:0100654)1.78866700
117Erythema (HP:0010783)1.78411890
118Abnormality of polysaccharide metabolism (HP:0011012)1.78312505
119Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78312505
120Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78312505
121Abnormality of carpal bone ossification (HP:0006257)1.76685327
122Oral leukoplakia (HP:0002745)1.75684689
123Skin ulcer (HP:0200042)1.75485790
124Esophageal neoplasm (HP:0100751)1.75199862
125Neoplasm of head and neck (HP:0012288)1.75199862
126Dilatation of the ascending aorta (HP:0005111)1.73659100
127Spinal rigidity (HP:0003306)1.73545949
128Hypercortisolism (HP:0001578)1.72640560
129Vasculitis (HP:0002633)1.72443584
130Palmar hyperkeratosis (HP:0010765)1.72394159
131Recurrent gram-negative bacterial infections (HP:0005420)1.71799294
132Abnormality of the nasal mucosa (HP:0000433)1.71755660
133Abnormality of macrophages (HP:0004311)1.71622422
134Hydroxyprolinuria (HP:0003080)1.71587633
135Abnormality of proline metabolism (HP:0010907)1.71587633
136Recurrent fungal infections (HP:0002841)1.71568081
137Thrombocytosis (HP:0001894)1.71463265
138Orthostatic hypotension (HP:0001278)1.71193538
139Abnormality of glutamine family amino acid metabolism (HP:0010902)1.70589308
140Hypotrichosis (HP:0001006)1.70583331
141Follicular hyperkeratosis (HP:0007502)1.70583252
142Hepatocellular necrosis (HP:0001404)1.69660049
143Popliteal pterygium (HP:0009756)1.69637799
144Bone pain (HP:0002653)1.69157128
145Hyperhidrosis (HP:0000975)1.68561463
146Type I transferrin isoform profile (HP:0003642)1.68467984
147Selective tooth agenesis (HP:0001592)1.68324385
148Generalized amyotrophy (HP:0003700)1.67887888
149Hypoalphalipoproteinemia (HP:0003233)1.67409701
150Elbow flexion contracture (HP:0002987)1.67260250
151Abnormality of complement system (HP:0005339)1.66840875
152Autoamputation (HP:0001218)1.66579871
153Vertebral hypoplasia (HP:0008417)1.66548318
154Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.66548318
155Sparse eyelashes (HP:0000653)1.66483863
156Short clavicles (HP:0000894)1.65499151
157Myocardial infarction (HP:0001658)1.65436361
158Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65400565
159Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65400565
160Palmoplantar hyperkeratosis (HP:0000972)1.64378874
161Acute necrotizing encephalopathy (HP:0006965)1.63574420
162Abnormal cartilage morphology (HP:0002763)1.62952836
163Autoimmune thrombocytopenia (HP:0001973)1.62754623
164Neck muscle weakness (HP:0000467)1.62474020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.72855859
2PIM23.80437869
3TESK13.16147198
4GRK52.65187160
5LIMK12.62616729
6MST42.52784142
7IRAK32.49226938
8MAPKAPK32.36764651
9TESK22.27871631
10MST1R2.25517406
11LRRK22.23809377
12TBK11.87358852
13RPS6KB21.70626553
14TYK21.67060915
15MAP3K31.60660084
16MAP4K11.59199084
17MAP3K121.57748042
18ARAF1.57680349
19ERN11.52728313
20MAP3K21.49298812
21MATK1.47418828
22KDR1.46402026
23MAP3K141.45582875
24BLK1.41961548
25MAP2K21.39297210
26ZAP701.38047508
27NEK91.37781450
28TRIB31.35272990
29TRPM71.32929236
30JAK31.28157670
31ILK1.25260350
32EPHB21.22128606
33EPHA21.21918313
34STK101.21754915
35FGFR41.18641655
36PDK21.14353656
37NME11.13640350
38BMPR21.13361688
39TAOK21.12490735
40NEK11.10314092
41VRK21.08516931
42BUB11.08301663
43STK161.06877452
44SCYL21.06778061
45TTN1.06387082
46RPS6KA41.05236087
47TXK1.04467973
48TGFBR11.04250093
49TEC1.03506433
50MAP2K11.02066307
51PRKG21.01948258
52MAP2K31.01878933
53MAP3K111.01330687
54EPHB11.00806676
55DAPK10.99587366
56NTRK10.99437675
57ERBB40.97096721
58IKBKB0.96304273
59GRK70.94372405
60PKN20.93952123
61IKBKE0.92549197
62ABL20.87187038
63KIT0.85550191
64JAK10.83310147
65CDK80.81646905
66MYLK0.81035209
67PIM10.80551761
68MOS0.80284023
69SIK10.80007288
70EPHA30.79605081
71PBK0.74554781
72ITK0.73271855
73TRIM280.73271056
74DDR20.73167301
75PIK3CA0.72649514
76KSR20.71711717
77PDGFRA0.68525007
78TLK10.68249466
79MAPKAPK50.64612276
80LCK0.62486743
81MARK30.62293134
82MUSK0.61440216
83BTK0.61212369
84PAK40.60826643
85GRK60.60355604
86ADRBK10.60154309
87BMPR1B0.59747820
88FLT30.59186780
89TGFBR20.58689138
90DAPK30.56960096
91RIPK10.56200078
92LATS10.55883712
93CSF1R0.55117613
94EIF2AK30.55081754
95FER0.54349808
96PIK3CG0.53837976
97CSK0.53529467
98LATS20.53418717
99EIF2AK10.52706596
100MAPKAPK20.52629701
101STK240.52257287
102CAMK2G0.52113604
103LMTK20.51126926
104PTK20.51059106
105MAP3K10.50001378
106SYK0.49197568
107MAP3K90.49149322
108CAMKK20.48797949
109EEF2K0.48789881
110BCKDK0.48181773
111STK380.47963731
112MAP3K80.47468985
113ERBB30.47288061
114RET0.47024485
115ROCK20.46912214
116FGFR30.44908795
117HCK0.43816290
118PRPF4B0.43781021
119MAPK40.43276458
120SIK30.42908432
121MET0.42353330
122PAK10.42248212
123PRKCI0.41545741
124ROCK10.41230752
125TAOK10.40567334
126PTK60.40047818
127FRK0.39542485
128NLK0.39375264
129BRAF0.37423056
130BMX0.37345994
131JAK20.36466854
132CAMK2D0.36017465
133BCR0.34826411
134DMPK0.32021256
135PAK20.29283715
136MELK0.28637738
137STK38L0.28342228
138PDPK10.26732861
139ABL10.26513044
140EGFR0.26478552
141PRKCD0.25201110
142AURKB0.24677239

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.91845344
2Proteasome_Homo sapiens_hsa030503.31496301
3Other glycan degradation_Homo sapiens_hsa005112.51195512
4Oxidative phosphorylation_Homo sapiens_hsa001902.46525352
5Galactose metabolism_Homo sapiens_hsa000522.36350950
6Parkinsons disease_Homo sapiens_hsa050122.35888019
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04841052
8Leishmaniasis_Homo sapiens_hsa051401.94156221
9Graft-versus-host disease_Homo sapiens_hsa053321.92704908
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.91833624
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.89924527
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.89077816
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79199511
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76432346
15Vibrio cholerae infection_Homo sapiens_hsa051101.72710564
16Lysosome_Homo sapiens_hsa041421.58775539
17Pertussis_Homo sapiens_hsa051331.54836746
18Salmonella infection_Homo sapiens_hsa051321.54737763
19Alzheimers disease_Homo sapiens_hsa050101.54081986
20Hematopoietic cell lineage_Homo sapiens_hsa046401.49904154
21Shigellosis_Homo sapiens_hsa051311.49059464
22Fatty acid elongation_Homo sapiens_hsa000621.48439524
23Legionellosis_Homo sapiens_hsa051341.44355085
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42608171
25Antigen processing and presentation_Homo sapiens_hsa046121.40395085
26Malaria_Homo sapiens_hsa051441.37808895
27Fructose and mannose metabolism_Homo sapiens_hsa000511.37549198
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.36779014
29ECM-receptor interaction_Homo sapiens_hsa045121.35742128
30Allograft rejection_Homo sapiens_hsa053301.33907441
31Huntingtons disease_Homo sapiens_hsa050161.33367100
32Thyroid cancer_Homo sapiens_hsa052161.32979318
33Toxoplasmosis_Homo sapiens_hsa051451.31757280
34Apoptosis_Homo sapiens_hsa042101.26627993
35Phagosome_Homo sapiens_hsa041451.24615235
36Primary immunodeficiency_Homo sapiens_hsa053401.23213606
37Measles_Homo sapiens_hsa051621.23118437
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21287482
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21027139
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19474694
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19117733
42Caffeine metabolism_Homo sapiens_hsa002321.17640177
43Tyrosine metabolism_Homo sapiens_hsa003501.15406277
44Staphylococcus aureus infection_Homo sapiens_hsa051501.13208029
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11586407
46Viral myocarditis_Homo sapiens_hsa054161.11404291
47Tuberculosis_Homo sapiens_hsa051521.11055659
48Rheumatoid arthritis_Homo sapiens_hsa053231.08469930
49Phenylalanine metabolism_Homo sapiens_hsa003601.07985099
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.07487176
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05865136
52Osteoclast differentiation_Homo sapiens_hsa043801.05597785
53Sphingolipid metabolism_Homo sapiens_hsa006001.04413060
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04360114
55Autoimmune thyroid disease_Homo sapiens_hsa053201.02060813
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99154057
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98109253
58Amoebiasis_Homo sapiens_hsa051460.97643276
59p53 signaling pathway_Homo sapiens_hsa041150.96712145
60TNF signaling pathway_Homo sapiens_hsa046680.95903185
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95704290
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.92802714
63Bladder cancer_Homo sapiens_hsa052190.92645430
64N-Glycan biosynthesis_Homo sapiens_hsa005100.92394810
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90885391
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90049350
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81291180
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80176319
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78338678
70Protein export_Homo sapiens_hsa030600.77622665
71Pyrimidine metabolism_Homo sapiens_hsa002400.76123578
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75760001
73Sulfur metabolism_Homo sapiens_hsa009200.75563704
74Endocytosis_Homo sapiens_hsa041440.75388018
75Glutathione metabolism_Homo sapiens_hsa004800.74704550
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74235357
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73598285
78Influenza A_Homo sapiens_hsa051640.73389263
79Histidine metabolism_Homo sapiens_hsa003400.73238368
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.73206864
81Sulfur relay system_Homo sapiens_hsa041220.71294244
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70685670
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69702901
84Chemical carcinogenesis_Homo sapiens_hsa052040.68609962
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68472243
86Platelet activation_Homo sapiens_hsa046110.67284638
87Hepatitis B_Homo sapiens_hsa051610.67193135
88Carbon metabolism_Homo sapiens_hsa012000.65929278
89Collecting duct acid secretion_Homo sapiens_hsa049660.65618231
90Small cell lung cancer_Homo sapiens_hsa052220.64155497
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64128081
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63500565
93Starch and sucrose metabolism_Homo sapiens_hsa005000.63416469
94T cell receptor signaling pathway_Homo sapiens_hsa046600.63173440
95Complement and coagulation cascades_Homo sapiens_hsa046100.63149512
96Proteoglycans in cancer_Homo sapiens_hsa052050.62814649
97Type I diabetes mellitus_Homo sapiens_hsa049400.62447669
98Focal adhesion_Homo sapiens_hsa045100.61779046
99Adherens junction_Homo sapiens_hsa045200.60892257
100Epstein-Barr virus infection_Homo sapiens_hsa051690.59985055
101Hepatitis C_Homo sapiens_hsa051600.59904425
102Protein digestion and absorption_Homo sapiens_hsa049740.58498483
103Pentose phosphate pathway_Homo sapiens_hsa000300.57711273
104RNA polymerase_Homo sapiens_hsa030200.56392685
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55997891
106Chronic myeloid leukemia_Homo sapiens_hsa052200.55669095
107Asthma_Homo sapiens_hsa053100.55384033
108Mineral absorption_Homo sapiens_hsa049780.52659772
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49995427
110Acute myeloid leukemia_Homo sapiens_hsa052210.49556998
111Folate biosynthesis_Homo sapiens_hsa007900.49498647
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.49180243
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48362241
114Herpes simplex infection_Homo sapiens_hsa051680.47273126
115Pyruvate metabolism_Homo sapiens_hsa006200.46762045
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.46607568
117VEGF signaling pathway_Homo sapiens_hsa043700.45014825
118Renal cell carcinoma_Homo sapiens_hsa052110.44590156
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43390423
120Renin-angiotensin system_Homo sapiens_hsa046140.42301726
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41500484
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.41497778
123B cell receptor signaling pathway_Homo sapiens_hsa046620.39604625
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37402591
125Pancreatic cancer_Homo sapiens_hsa052120.35893510
126African trypanosomiasis_Homo sapiens_hsa051430.35686491
127Viral carcinogenesis_Homo sapiens_hsa052030.34473362

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