RXRG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)7.54808142
2skeletal muscle contraction (GO:0003009)6.60729581
3actin filament-based movement (GO:0030048)5.64287301
4regulation of synapse structural plasticity (GO:0051823)5.32952028
5response to muscle activity (GO:0014850)5.03251949
6striatum development (GO:0021756)5.02458138
7response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.99305842
8negative regulation of cytosolic calcium ion concentration (GO:0051481)4.98355086
9melanin biosynthetic process (GO:0042438)4.90736648
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.86657221
11prepulse inhibition (GO:0060134)4.73655694
12regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.69951964
13synaptic transmission, dopaminergic (GO:0001963)4.51028633
14regulation of membrane repolarization (GO:0060306)4.47104210
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.43116576
16melanin metabolic process (GO:0006582)4.42714544
17skeletal muscle fiber development (GO:0048741)4.42098815
18retinal rod cell development (GO:0046548)4.39324240
19negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.39019884
20sarcomere organization (GO:0045214)4.32108858
21creatine metabolic process (GO:0006600)4.23534943
22negative regulation of potassium ion transmembrane transport (GO:1901380)4.22746388
23myotube cell development (GO:0014904)4.19386166
24muscle contraction (GO:0006936)4.19091182
25tricarboxylic acid cycle (GO:0006099)4.15214641
26regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.11448956
27secondary metabolite biosynthetic process (GO:0044550)4.01363559
28adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.00158992
29regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.97669777
30cardiac myofibril assembly (GO:0055003)3.96672581
31cardiac muscle contraction (GO:0060048)3.96084033
32striated muscle hypertrophy (GO:0014897)3.92669013
33neurotransmitter-gated ion channel clustering (GO:0072578)3.89266638
34regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.86950881
35muscle fiber development (GO:0048747)3.85781290
36glycogen catabolic process (GO:0005980)3.83689856
37muscle system process (GO:0003012)3.78142042
38myofibril assembly (GO:0030239)3.72506032
39adenosine receptor signaling pathway (GO:0001973)3.71574824
40behavioral response to cocaine (GO:0048148)3.68785990
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.67543850
42adult heart development (GO:0007512)3.66179675
43auditory behavior (GO:0031223)3.61817910
44sarcoplasmic reticulum calcium ion transport (GO:0070296)3.58349972
45muscle cell cellular homeostasis (GO:0046716)3.58200946
46skeletal muscle adaptation (GO:0043501)3.57558498
47cAMP catabolic process (GO:0006198)3.56935665
48regulation of skeletal muscle contraction (GO:0014819)3.56027147
49glucan catabolic process (GO:0009251)3.55483501
50positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.55407166
51cardiac muscle cell development (GO:0055013)3.55140359
52regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.53615150
53dopamine receptor signaling pathway (GO:0007212)3.52718119
54regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.52106922
55positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.51820444
56regulation of striated muscle contraction (GO:0006942)3.47673085
57regulation of cell communication by electrical coupling (GO:0010649)3.46523662
58carnitine shuttle (GO:0006853)3.45876220
59actin-myosin filament sliding (GO:0033275)3.45837132
60muscle filament sliding (GO:0030049)3.45837132
61response to amphetamine (GO:0001975)3.45037341
62neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.44995787
63plasma membrane repair (GO:0001778)3.39051722
64vocalization behavior (GO:0071625)3.38990539
65cell communication involved in cardiac conduction (GO:0086065)3.38571181
66striated muscle contraction (GO:0006941)3.37094872
67negative regulation of calcium ion transmembrane transport (GO:1903170)3.36878089
68negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.36878089
69succinate metabolic process (GO:0006105)3.36539798
70gluconeogenesis (GO:0006094)3.36482884
71muscle hypertrophy (GO:0014896)3.36470968
72cardiac conduction (GO:0061337)3.35546704
73glycogen biosynthetic process (GO:0005978)3.35338484
74glucan biosynthetic process (GO:0009250)3.35338484
75striated muscle adaptation (GO:0014888)3.34886563
76regulation of female receptivity (GO:0045924)3.34086916
77regulation of acyl-CoA biosynthetic process (GO:0050812)3.34082877
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.31810802
79* skeletal muscle tissue development (GO:0007519)3.30670284
80fructose metabolic process (GO:0006000)3.30491342
81cellular polysaccharide catabolic process (GO:0044247)3.28923490
82regulation of glucokinase activity (GO:0033131)3.28709520
83regulation of hexokinase activity (GO:1903299)3.28709520
84response to inactivity (GO:0014854)3.28075809
85regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.26454099
86relaxation of muscle (GO:0090075)3.25620478
87cardiac cell development (GO:0055006)3.25055695
88myotube differentiation (GO:0014902)3.24951202
89cardiac muscle cell action potential involved in contraction (GO:0086002)3.24157976
90regulation of heart rate by cardiac conduction (GO:0086091)3.23061572
91regulation of glutamate receptor signaling pathway (GO:1900449)3.21791790
92cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21694265
93detection of calcium ion (GO:0005513)3.21432143
94neuromuscular synaptic transmission (GO:0007274)3.20784032
95positive regulation of synaptic transmission, GABAergic (GO:0032230)3.20519476
96cardiac muscle cell action potential (GO:0086001)3.20210613
97regulation of relaxation of muscle (GO:1901077)3.20197787
98regulation of calcium ion transmembrane transport (GO:1903169)3.19399256
99regulation of calcium ion transmembrane transporter activity (GO:1901019)3.19399256
100regulation of actin filament-based movement (GO:1903115)3.17987866
101regulation of dendritic spine morphogenesis (GO:0061001)3.17339132
102regulation of short-term neuronal synaptic plasticity (GO:0048172)3.17241625
103activation of protein kinase A activity (GO:0034199)3.15218119
104striated muscle cell development (GO:0055002)3.14997857
105ventricular cardiac muscle cell action potential (GO:0086005)3.14517040
106regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.13732809
107female mating behavior (GO:0060180)3.12827446
108regulation of glutamate secretion (GO:0014048)3.12387069
109muscle cell fate commitment (GO:0042693)3.10982046
110regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.10364128
111regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.10364128
112cardiac muscle tissue morphogenesis (GO:0055008)3.10340904
113NADH metabolic process (GO:0006734)3.09337337
114regulation of long-term neuronal synaptic plasticity (GO:0048169)3.09005110
115cyclic nucleotide catabolic process (GO:0009214)3.07902042
116fatty acid transmembrane transport (GO:1902001)3.07854010
117muscle tissue morphogenesis (GO:0060415)3.07426310
118cell communication by electrical coupling (GO:0010644)3.06918118
119peristalsis (GO:0030432)3.06030989
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05430197
121regulation of cofactor metabolic process (GO:0051193)3.03212330
122regulation of coenzyme metabolic process (GO:0051196)3.03212330
123muscle structure development (GO:0061061)3.01828254
124regulation of the force of heart contraction (GO:0002026)3.01804720
125relaxation of cardiac muscle (GO:0055119)3.01477755
126negative regulation of protein localization to cell surface (GO:2000009)3.00935022
127response to epinephrine (GO:0071871)3.00785568
128response to caffeine (GO:0031000)3.00701534
129muscle organ development (GO:0007517)3.00551316
130skeletal muscle tissue regeneration (GO:0043403)3.00404465
131regulation of skeletal muscle cell differentiation (GO:2001014)2.99510683
132regulation of protein kinase A signaling (GO:0010738)2.98673881
133melanocyte differentiation (GO:0030318)2.98318095
134locomotory exploration behavior (GO:0035641)2.97973180
135potassium ion export (GO:0071435)2.97735418
136synaptic vesicle maturation (GO:0016188)2.96881656
137negative regulation of potassium ion transport (GO:0043267)2.96291642
138mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95887122
139regulation of voltage-gated calcium channel activity (GO:1901385)2.94055045
140polysaccharide catabolic process (GO:0000272)2.93926857
141actomyosin structure organization (GO:0031032)2.93764974
142myoblast fusion (GO:0007520)2.93389345
143hexose biosynthetic process (GO:0019319)2.93151634
144cardiac muscle hypertrophy in response to stress (GO:0014898)2.92555322
145muscle hypertrophy in response to stress (GO:0003299)2.92555322
146cardiac muscle adaptation (GO:0014887)2.92555322
147regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91378467
148multicellular organismal signaling (GO:0035637)2.90723122
149cAMP metabolic process (GO:0046058)2.88648320
150response to auditory stimulus (GO:0010996)2.87498970
151substrate-independent telencephalic tangential migration (GO:0021826)2.87489740
152substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.87489740
153regulation of cation channel activity (GO:2001257)2.86631502
154regulation of sarcomere organization (GO:0060297)2.86368798
155G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.84341802
156positive regulation of neurotransmitter transport (GO:0051590)2.84287975
157regulation of ATPase activity (GO:0043462)2.83709408
158regulation of ATP catabolic process (GO:1903289)2.83709408
159cardiac muscle hypertrophy (GO:0003300)2.82441305
160regulation of neuronal synaptic plasticity (GO:0048168)2.82350506
161positive regulation of renal sodium excretion (GO:0035815)2.81708369
162pigment cell differentiation (GO:0050931)2.81391533
163regulation of heart rate (GO:0002027)2.81085112
164glycogen metabolic process (GO:0005977)2.77691730
165cellular glucan metabolic process (GO:0006073)2.70526353
166glucan metabolic process (GO:0044042)2.70526353
167positive regulation of cation channel activity (GO:2001259)2.67011238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.68200208
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.38116628
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.86947172
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83260115
5GBX2_23144817_ChIP-Seq_PC3_Human2.82818481
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.82512670
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78082301
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.58146192
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40268288
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40268288
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40011919
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38911316
13DROSHA_22980978_ChIP-Seq_HELA_Human2.38172877
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33858186
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30170736
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.30042992
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20945552
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19675098
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.18414281
20REST_21632747_ChIP-Seq_MESCs_Mouse2.15808699
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14946141
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.05249287
23AR_21572438_ChIP-Seq_LNCaP_Human2.02204791
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.98708837
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94121681
26* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92819252
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.92798953
28IGF1R_20145208_ChIP-Seq_DFB_Human1.90717041
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.80791053
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76110485
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.75164182
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.74515158
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71914003
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71426964
35FUS_26573619_Chip-Seq_HEK293_Human1.62330647
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55708901
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.53792154
38* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50923710
39* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50538037
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49514630
41* EZH2_27294783_Chip-Seq_NPCs_Mouse1.48639400
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47932426
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46547991
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42741414
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40415793
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38826848
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37597239
48* P53_22387025_ChIP-Seq_ESCs_Mouse1.35988452
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35206213
50* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35031389
51* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33163592
52CTCF_27219007_Chip-Seq_Bcells_Human1.30596073
53* NANOG_18555785_Chip-Seq_ESCs_Mouse1.29166423
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28982891
55CBP_20019798_ChIP-Seq_JUKART_Human1.28982891
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.27615581
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.27615581
58TAF15_26573619_Chip-Seq_HEK293_Human1.27424263
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26968758
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26562936
61* NFE2_27457419_Chip-Seq_LIVER_Mouse1.26547810
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26424708
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.26274285
64* CRX_20693478_ChIP-Seq_RETINA_Mouse1.25181036
65* SMAD4_21799915_ChIP-Seq_A2780_Human1.25047198
66* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24473062
67* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23989315
68GATA1_22025678_ChIP-Seq_K562_Human1.23157036
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.21252959
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19771577
71* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19607805
72VDR_22108803_ChIP-Seq_LS180_Human1.19050613
73* E2F1_18555785_Chip-Seq_ESCs_Mouse1.19048569
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18564684
75* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16912396
76* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16015876
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15981114
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15924330
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15330491
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14640284
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14503255
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11796919
83* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11790147
84* SMAD3_21741376_ChIP-Seq_EPCs_Human1.11654503
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.11483994
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10329584
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10329584
88* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09866371
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09651517
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08892733
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08740641
92MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08587378
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08170444
94* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07675612
95* CMYC_18555785_Chip-Seq_ESCs_Mouse1.07358745
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07288211
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06677563
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06217607
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06131105
100ER_23166858_ChIP-Seq_MCF-7_Human1.06129169
101* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06086646
102AR_19668381_ChIP-Seq_PC3_Human1.06040654
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05405152
104* TBL1_22424771_ChIP-Seq_293T_Human1.04914165
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04460473
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04368385
107FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03434543
108CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02501772
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02225034
110* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01635652
111ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01602777
112* SMAD3_21741376_ChIP-Seq_HESCs_Human1.00632274
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00429826
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00232178
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98943877
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95614319
117* KLF4_19829295_ChIP-Seq_ESCs_Human0.94836694
118AHR_22903824_ChIP-Seq_MCF-7_Human0.94230020
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94165082
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93664450
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93542710
122* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93515578
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91904714
124ZNF274_21170338_ChIP-Seq_K562_Hela0.90328326
125KDM2B_26808549_Chip-Seq_K562_Human0.89839997
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89365122
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89334159
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88970580
129STAT3_23295773_ChIP-Seq_U87_Human0.88927536
130* P300_19829295_ChIP-Seq_ESCs_Human0.87690298
131AR_25329375_ChIP-Seq_VCAP_Human0.87486298
132TCF4_23295773_ChIP-Seq_U87_Human0.85736521
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84061737
134ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83445953
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82719144
136* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82411492
137SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81670302
138CBX2_27304074_Chip-Seq_ESCs_Mouse0.81531029
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80807833
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80598439
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.79932264
142* BCAT_22108803_ChIP-Seq_LS180_Human0.79501216
143RXR_22158963_ChIP-Seq_LIVER_Mouse0.76983029
144OCT4_20526341_ChIP-Seq_ESCs_Human0.76203206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002822_catalepsy5.28772267
2MP0002837_dystrophic_cardiac_calcinosis4.61280784
3MP0000751_myopathy4.29801431
4MP0003646_muscle_fatigue4.29513997
5MP0000372_irregular_coat_pigmentation4.19884751
6MP0004859_abnormal_synaptic_plasticity3.68295136
7MP0005171_absent_coat_pigmentation3.57643377
8MP0004215_abnormal_myocardial_fiber2.99287358
9MP0001529_abnormal_vocalization2.82624689
10MP0000749_muscle_degeneration2.81723152
11MP0004084_abnormal_cardiac_muscle2.74754493
12MP0003136_yellow_coat_color2.61143888
13MP0003635_abnormal_synaptic_transmissio2.54063115
14* MP0004036_abnormal_muscle_relaxation2.48784141
15MP0004130_abnormal_muscle_cell2.44767965
16MP0009745_abnormal_behavioral_response2.41752978
17MP0003880_abnormal_central_pattern2.39448313
18MP0005330_cardiomyopathy2.39122544
19MP0003137_abnormal_impulse_conducting2.24992783
20MP0005408_hypopigmentation2.20041483
21MP0002063_abnormal_learning/memory/cond2.19439972
22MP0002638_abnormal_pupillary_reflex2.17448073
23MP0005620_abnormal_muscle_contractility2.09897284
24MP0004270_analgesia2.09664796
25MP0004145_abnormal_muscle_electrophysio2.08647962
26MP0004087_abnormal_muscle_fiber2.04531340
27MP0004085_abnormal_heartbeat1.89149829
28MP0002972_abnormal_cardiac_muscle1.87618849
29MP0002909_abnormal_adrenal_gland1.86454118
30MP0002106_abnormal_muscle_physiology1.82181939
31MP0002064_seizures1.79626969
32MP0005075_abnormal_melanosome_morpholog1.78659688
33MP0002572_abnormal_emotion/affect_behav1.77235211
34* MP0005386_behavior/neurological_phenoty1.70850507
35* MP0004924_abnormal_behavior1.70850507
36MP0009046_muscle_twitch1.70719231
37MP0001486_abnormal_startle_reflex1.68993025
38MP0000747_muscle_weakness1.67723933
39MP0002272_abnormal_nervous_system1.67641577
40MP0005451_abnormal_body_composition1.67102180
41MP0005646_abnormal_pituitary_gland1.65137131
42MP0002269_muscular_atrophy1.64636935
43MP0005670_abnormal_white_adipose1.63082825
44MP0006036_abnormal_mitochondrial_physio1.61752955
45MP0005253_abnormal_eye_physiology1.61600972
46MP0001968_abnormal_touch/_nociception1.56865696
47MP0008775_abnormal_heart_ventricle1.56633436
48MP0001544_abnormal_cardiovascular_syste1.55790394
49MP0005385_cardiovascular_system_phenoty1.55790394
50MP0005248_abnormal_Harderian_gland1.55553905
51MP0000759_abnormal_skeletal_muscle1.54913523
52MP0005369_muscle_phenotype1.53255350
53MP0004484_altered_response_of1.51860086
54MP0000750_abnormal_muscle_regeneration1.50978522
55MP0000733_abnormal_muscle_development1.40661753
56MP0004381_abnormal_hair_follicle1.39918089
57MP0005409_darkened_coat_color1.39525659
58MP0004233_abnormal_muscle_weight1.38858934
59MP0006138_congestive_heart_failure1.31975039
60MP0002332_abnormal_exercise_endurance1.28316154
61MP0002102_abnormal_ear_morphology1.26523110
62MP0005551_abnormal_eye_electrophysiolog1.25610123
63MP0005535_abnormal_body_temperature1.22330138
64MP0010630_abnormal_cardiac_muscle1.20760458
65MP0001440_abnormal_grooming_behavior1.18604300
66MP0005423_abnormal_somatic_nervous1.18296371
67MP0002938_white_spotting1.17898629
68MP0001324_abnormal_eye_pigmentation1.16380621
69MP0001984_abnormal_olfaction1.16040270
70MP0002734_abnormal_mechanical_nocicepti1.15316125
71MP0000013_abnormal_adipose_tissue1.14624352
72MP0005085_abnormal_gallbladder_physiolo1.13808160
73MP0009780_abnormal_chondrocyte_physiolo1.12755486
74MP0008569_lethality_at_weaning1.11134679
75MP0001905_abnormal_dopamine_level1.10019250
76MP0006035_abnormal_mitochondrial_morpho1.08519093
77MP0005666_abnormal_adipose_tissue1.07549465
78MP0000015_abnormal_ear_pigmentation1.05327529
79MP0001501_abnormal_sleep_pattern1.03215446
80MP0008874_decreased_physiological_sensi1.02335004
81MP0002557_abnormal_social/conspecific_i1.01367237
82MP0001970_abnormal_pain_threshold1.00907584
83MP0003221_abnormal_cardiomyocyte_apopto1.00162628
84MP0002067_abnormal_sensory_capabilities1.00047594
85MP0003633_abnormal_nervous_system0.98688208
86MP0003075_altered_response_to0.98370758
87MP0002736_abnormal_nociception_after0.98056586
88MP0005167_abnormal_blood-brain_barrier0.97723739
89MP0002095_abnormal_skin_pigmentation0.97489562
90MP0005187_abnormal_penis_morphology0.96838448
91MP0003122_maternal_imprinting0.96474920
92MP0002733_abnormal_thermal_nociception0.95627158
93MP0003690_abnormal_glial_cell0.95010219
94MP0000230_abnormal_systemic_arterial0.90737066
95MP0002066_abnormal_motor_capabilities/c0.90614245
96MP0002735_abnormal_chemical_nociception0.90440665
97MP0004043_abnormal_pH_regulation0.90204250
98MP0002127_abnormal_cardiovascular_syste0.90185146
99MP0008961_abnormal_basal_metabolism0.88324940
100MP0004811_abnormal_neuron_physiology0.88114974
101MP0000569_abnormal_digit_pigmentation0.85149404
102MP0004142_abnormal_muscle_tone0.81661979
103MP0006276_abnormal_autonomic_nervous0.81134471
104MP0005584_abnormal_enzyme/coenzyme_acti0.80428929
105MP0006072_abnormal_retinal_apoptosis0.79805180
106MP0001502_abnormal_circadian_rhythm0.79787875
107MP0005375_adipose_tissue_phenotype0.79441489
108MP0000371_diluted_coat_color0.78778499
109MP0003011_delayed_dark_adaptation0.77742566
110MP0002971_abnormal_brown_adipose0.77212741
111MP0002078_abnormal_glucose_homeostasis0.76277570
112MP0003567_abnormal_fetal_cardiomyocyte0.75441286
113MP0002108_abnormal_muscle_morphology0.74625238
114MP0008872_abnormal_physiological_respon0.72703983
115MP0001299_abnormal_eye_distance/0.70986111
116MP0002234_abnormal_pharynx_morphology0.70465204
117MP0003631_nervous_system_phenotype0.70037627
118MP0005645_abnormal_hypothalamus_physiol0.69735379
119MP0003329_amyloid_beta_deposits0.69367866
120MP0002229_neurodegeneration0.68550170
121MP0004510_myositis0.68208109
122MP0002090_abnormal_vision0.68103669
123MP0005266_abnormal_metabolism0.67186803
124MP0001177_atelectasis0.66818771
125MP0002877_abnormal_melanocyte_morpholog0.66095953
126MP0002752_abnormal_somatic_nervous0.66039765
127MP0003879_abnormal_hair_cell0.65753429
128MP0002069_abnormal_eating/drinking_beha0.64733776
129MP0010030_abnormal_orbit_morphology0.64717640
130MP0010329_abnormal_lipoprotein_level0.63534282
131MP0005197_abnormal_uvea_morphology0.62927402
132MP0002882_abnormal_neuron_morphology0.62431199
133MP0003283_abnormal_digestive_organ0.60556796
134MP0005448_abnormal_energy_balance0.60125937
135MP0000003_abnormal_adipose_tissue0.60068526
136MP0004885_abnormal_endolymph0.58427978
137MP0004134_abnormal_chest_morphology0.57532119
138MP0005391_vision/eye_phenotype0.57134975
139MP0005195_abnormal_posterior_eye0.57097429
140MP0003195_calcinosis0.56711043

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)8.57730153
2Exercise-induced myalgia (HP:0003738)6.21391688
3Distal arthrogryposis (HP:0005684)5.48215735
4Sudden death (HP:0001699)5.43377285
5Calf muscle hypertrophy (HP:0008981)5.08271143
6Myokymia (HP:0002411)5.06192285
7Muscle hypertrophy of the lower extremities (HP:0008968)4.92192684
8Exercise-induced muscle cramps (HP:0003710)4.78951603
9Atrial fibrillation (HP:0005110)4.71842014
10Round ear (HP:0100830)4.55060899
11Primary atrial arrhythmia (HP:0001692)4.46722748
12Focal motor seizures (HP:0011153)4.40212328
13Prolonged QT interval (HP:0001657)4.35673528
14Myoglobinuria (HP:0002913)4.33914814
15Supraventricular tachycardia (HP:0004755)4.29098749
16Myopathic facies (HP:0002058)4.16741036
17Supraventricular arrhythmia (HP:0005115)4.16448300
18Abnormality of the calf musculature (HP:0001430)4.06232334
19Atrioventricular block (HP:0001678)4.05700132
20Bundle branch block (HP:0011710)3.99256191
21Posterior subcapsular cataract (HP:0007787)3.96858504
22Ventricular tachycardia (HP:0004756)3.92543333
23Heart block (HP:0012722)3.91141779
24Ulnar deviation of the wrist (HP:0003049)3.86967961
25Fetal akinesia sequence (HP:0001989)3.68297020
26Centrally nucleated skeletal muscle fibers (HP:0003687)3.65124140
27Abnormal atrioventricular conduction (HP:0005150)3.61510408
28Calcaneovalgus deformity (HP:0001848)3.60671219
29Muscle fiber splitting (HP:0003555)3.55877330
30Abnormal EKG (HP:0003115)3.52416752
31Frequent falls (HP:0002359)3.49886087
32Neck muscle weakness (HP:0000467)3.48762147
33Palpitations (HP:0001962)3.46892381
34Syncope (HP:0001279)3.34770449
35Hyporeflexia of lower limbs (HP:0002600)3.28545607
36EMG: myopathic abnormalities (HP:0003458)3.25778725
37Myotonia (HP:0002486)3.25571498
38Deformed tarsal bones (HP:0008119)3.22153484
39Subaortic stenosis (HP:0001682)3.21755545
40Abnormality of the left ventricular outflow tract (HP:0011103)3.21755545
41Absent phalangeal crease (HP:0006109)3.15491215
42Difficulty running (HP:0009046)3.13316014
43Distal lower limb muscle weakness (HP:0009053)3.08738726
44Malignant hyperthermia (HP:0002047)3.04330222
45Lipoatrophy (HP:0100578)3.04159623
46Rhabdomyolysis (HP:0003201)3.04101789
47Ventricular arrhythmia (HP:0004308)2.98895063
48Ventricular fibrillation (HP:0001663)2.97238207
49Dilated cardiomyopathy (HP:0001644)2.92147605
50Abnormal mitochondria in muscle tissue (HP:0008316)2.85199969
51Asymmetric septal hypertrophy (HP:0001670)2.83218133
52Acute necrotizing encephalopathy (HP:0006965)2.82343262
53Resting tremor (HP:0002322)2.81504218
54Focal seizures (HP:0007359)2.80216277
55Blue irides (HP:0000635)2.78652714
56Anxiety (HP:0000739)2.72478137
57Distal lower limb amyotrophy (HP:0008944)2.72190387
58Abnormal finger flexion creases (HP:0006143)2.70054079
59Pheochromocytoma (HP:0002666)2.67700838
60Poor eye contact (HP:0000817)2.66918812
61Increased connective tissue (HP:0009025)2.64219113
62Increased variability in muscle fiber diameter (HP:0003557)2.64023205
63Ketoacidosis (HP:0001993)2.63858273
64Acute encephalopathy (HP:0006846)2.61608687
65Lower limb amyotrophy (HP:0007210)2.61461904
66EMG: neuropathic changes (HP:0003445)2.60362653
67Torticollis (HP:0000473)2.60053989
68Hyperinsulinemic hypoglycemia (HP:0000825)2.59872007
69Areflexia of lower limbs (HP:0002522)2.58108338
70Dysmetric saccades (HP:0000641)2.56180296
71Left ventricular hypertrophy (HP:0001712)2.54468344
72White forelock (HP:0002211)2.54244556
73Muscle stiffness (HP:0003552)2.52909899
74Hepatic necrosis (HP:0002605)2.51522542
75Right ventricular cardiomyopathy (HP:0011663)2.45841445
76Patchy hypopigmentation of hair (HP:0011365)2.45530010
77Impaired social interactions (HP:0000735)2.44956230
78Abnormal social behavior (HP:0012433)2.44956230
79Neuroendocrine neoplasm (HP:0100634)2.44107781
80Weak cry (HP:0001612)2.43078819
81Progressive macrocephaly (HP:0004481)2.42798129
82Hypoglycemic seizures (HP:0002173)2.42121602
83Hyperkalemia (HP:0002153)2.41085683
84Abnormality of skeletal muscle fiber size (HP:0012084)2.39826784
85Subcapsular cataract (HP:0000523)2.38449029
86Gowers sign (HP:0003391)2.37527269
87Hip contracture (HP:0003273)2.35986293
88Generalized muscle weakness (HP:0003324)2.33606146
89Insulin-resistant diabetes mellitus (HP:0000831)2.33343558
90Aplasia/Hypoplasia of the macula (HP:0008059)2.33272415
91Hepatocellular necrosis (HP:0001404)2.26810638
92Craniofacial dystonia (HP:0012179)2.26403934
93Cerebral edema (HP:0002181)2.25069820
94Muscle fiber inclusion bodies (HP:0100299)2.24490823
95Focal dystonia (HP:0004373)2.24041506
96Impaired vibration sensation in the lower limbs (HP:0002166)2.23190913
97Mitochondrial inheritance (HP:0001427)2.21503459
98Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.19991020
99Central scotoma (HP:0000603)2.16236855
100Aplasia/Hypoplasia affecting the retina (HP:0008061)2.16170551
101Testicular atrophy (HP:0000029)2.15840233
102Ketosis (HP:0001946)2.15349421
103Depression (HP:0000716)2.12845210
104Mildly elevated creatine phosphokinase (HP:0008180)2.12831182
105Popliteal pterygium (HP:0009756)2.12558685
106Limb-girdle muscle atrophy (HP:0003797)2.12363378
107Increased CSF lactate (HP:0002490)2.09848983
108Broad-based gait (HP:0002136)2.08555867
109Proximal amyotrophy (HP:0007126)2.07091235
110Fatigable weakness (HP:0003473)2.06236846
111Abnormality of the neuromuscular junction (HP:0003398)2.06236846
112Hypoglycemic coma (HP:0001325)2.05314254
113Dysdiadochokinesis (HP:0002075)2.04749731
114Bulbar palsy (HP:0001283)2.01455087
115Visual hallucinations (HP:0002367)2.01047429
116Scapular winging (HP:0003691)2.00919152
117Abnormality of fatty-acid metabolism (HP:0004359)2.00650595
118Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00465451
119Dicarboxylic aciduria (HP:0003215)2.00465451
120Limb hypertonia (HP:0002509)1.99663017
121Metatarsus adductus (HP:0001840)1.98561667
122Difficulty climbing stairs (HP:0003551)1.98151718
123Increased muscle lipid content (HP:0009058)1.98021845
124Type 1 muscle fiber predominance (HP:0003803)1.95982371
125Abnormality of the foot musculature (HP:0001436)1.95463378
126Lactic acidosis (HP:0003128)1.93738495
127Aplasia/Hypoplasia of the fovea (HP:0008060)1.93311930
128Hypoplasia of the fovea (HP:0007750)1.93311930
129Hyperammonemia (HP:0001987)1.93306566
130Scotoma (HP:0000575)1.93198106
131Generalized tonic-clonic seizures (HP:0002069)1.91958188
132Intestinal atresia (HP:0011100)1.91619740
133Polar cataract (HP:0010696)1.90334138
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89455116
135Abnormality of alanine metabolism (HP:0010916)1.89455116
136Hyperalaninemia (HP:0003348)1.89455116
137Congenital stationary night blindness (HP:0007642)1.88982932
138Athetosis (HP:0002305)1.88403044
139Hyperglycinuria (HP:0003108)1.87838291
140Urinary urgency (HP:0000012)1.87691295
141Annular pancreas (HP:0001734)1.87354991
142Nonprogressive disorder (HP:0003680)1.85392149
143Action tremor (HP:0002345)1.84221794
144Foot dorsiflexor weakness (HP:0009027)1.83914476
145Type 2 muscle fiber atrophy (HP:0003554)1.83078672
146Exercise intolerance (HP:0003546)1.82875889
147Abnormality of the hip-girdle musculature (HP:0001445)1.82770877
148Abnormality of the musculature of the pelvis (HP:0001469)1.82770877
149Rimmed vacuoles (HP:0003805)1.82725498
150Ankle clonus (HP:0011448)1.82538664
151Hyperventilation (HP:0002883)1.82383552
152Hyperglycemia (HP:0003074)1.81599529
153Abnormality of the calcaneus (HP:0008364)1.81446171
154Muscular dystrophy (HP:0003560)1.81301703
155Akinesia (HP:0002304)1.81292866
156Large for gestational age (HP:0001520)1.77594269
157Respiratory insufficiency due to muscle weakness (HP:0002747)1.74639634
158Iris hypopigmentation (HP:0007730)1.73126602
159Abnormality of the shoulder girdle musculature (HP:0001435)1.70727030
160Ocular albinism (HP:0001107)1.70712049
161Aplasia of the musculature (HP:0100854)1.69866554
162Shoulder girdle muscle weakness (HP:0003547)1.69025567
163Steppage gait (HP:0003376)1.68011278
164Limb-girdle muscle weakness (HP:0003325)1.66877224
165Limited hip movement (HP:0008800)1.66367896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.10962118
2PHKG23.46358039
3PHKG13.46358039
4TTN2.99398150
5NTRK32.97177228
6LMTK22.79835445
7PINK12.68161039
8OBSCN2.31880293
9DAPK22.16376890
10PDK32.09159746
11PDK42.09159746
12PRKD32.02496942
13FRK1.94772805
14MAP3K91.85876784
15NEK11.84969836
16PIK3CG1.81470695
17KSR21.76836458
18ARAF1.65331289
19MARK11.55906791
20DMPK1.54049190
21MAP3K41.52920351
22CAMKK11.50458221
23TRIB31.48691555
24BCKDK1.46599370
25MAP3K131.41665588
26MAP2K41.36800551
27PIK3CA1.36022799
28MYLK1.33707792
29NTRK21.32849470
30MINK11.29725263
31SGK21.27411117
32PDK21.25667459
33DDR21.24039136
34ERBB31.21208668
35MUSK1.21141034
36TAOK11.20429698
37TNIK1.17461485
38GRK71.14739014
39SGK4941.14387154
40SGK2231.14387154
41CDK51.12059737
42SGK31.11628822
43MAP2K71.10843624
44EPHA31.10759390
45KSR11.10243950
46LIMK11.09777677
47TIE11.09753097
48PRPF4B1.08098166
49CAMKK21.07276992
50CAMK2A1.01547565
51STK380.95910467
52MAP4K20.95750171
53FES0.91963374
54CAMK2D0.90730520
55PAK60.89578798
56TRPM70.88180245
57MARK30.86272129
58FGFR20.86113696
59CAMK40.85810653
60MAPK120.85041272
61PAK30.84883050
62SGK10.84489783
63DYRK1B0.83042745
64RIPK40.82727841
65CCNB10.82357488
66MAPK130.79348021
67NTRK10.78848684
68RAF10.77940538
69PRKCH0.76186946
70DAPK10.75038631
71MOS0.74690551
72FLT30.72808370
73MAP2K60.72240839
74PDPK10.69408726
75PRKD10.68817279
76STK240.68564246
77AKT20.67649391
78CAMK2G0.67598072
79CAMK10.67364140
80MAP2K10.65064407
81PKN20.64389614
82PRKCG0.60946326
83MAP3K10.60726240
84NME10.60440903
85PDK10.60367936
86PRKG10.59981334
87CASK0.58996455
88CDC42BPA0.57696437
89PRKACA0.57119542
90INSRR0.56570279
91BMPR20.56058752
92UHMK10.55922582
93DAPK30.55791727
94MAP3K70.55780911
95MAP2K30.55543162
96MAP3K50.55474843
97CAMK2B0.54933511
98PRKACG0.54506512
99ROCK10.54360095
100PRKCE0.54012092
101LATS20.53744385
102MAPKAPK30.52757346
103RPS6KA30.51906599
104PTK2B0.49359049
105PRKAA10.48992346
106PKN10.48860513
107MAP3K120.48213199
108TYRO30.46629561
109RIPK10.46598669
110WNK30.46250831
111STK38L0.45868954
112STK110.45752828
113RPS6KA20.45745371
114PLK20.41777785
115MARK20.41301221
116PASK0.41014245
117PRKAA20.40765879
118CSNK1G20.40740339
119PRKACB0.38321088
120BRAF0.38197192
121SIK20.37763623
122DYRK1A0.37703827
123MAP3K20.37416618
124MAPK70.37113243
125RET0.36945632
126CSNK1G10.35642622
127EPHB10.34810079
128MAPK100.34629867
129FER0.33163589
130CSNK1G30.32224806
131CDK30.31182005
132MST1R0.29407005
133LATS10.28118204
134AKT30.28045927
135CSNK1A1L0.25172697
136FGFR30.24881095
137MAPK40.24858604
138GRK10.22048044
139CSNK1D0.21710236

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.71110610
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.87564056
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.76050938
4Cardiac muscle contraction_Homo sapiens_hsa042602.68520457
5Olfactory transduction_Homo sapiens_hsa047402.66138991
6Propanoate metabolism_Homo sapiens_hsa006402.48217566
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.46232478
8Parkinsons disease_Homo sapiens_hsa050122.33890773
9Dilated cardiomyopathy_Homo sapiens_hsa054142.21622890
10Morphine addiction_Homo sapiens_hsa050322.08889646
11GABAergic synapse_Homo sapiens_hsa047271.95429776
12Circadian entrainment_Homo sapiens_hsa047131.93969190
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.86264016
14Oxidative phosphorylation_Homo sapiens_hsa001901.84828072
15Fatty acid degradation_Homo sapiens_hsa000711.84654857
16Cocaine addiction_Homo sapiens_hsa050301.77338891
17Amphetamine addiction_Homo sapiens_hsa050311.76817770
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74794729
19Nicotine addiction_Homo sapiens_hsa050331.71427938
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69006333
21Butanoate metabolism_Homo sapiens_hsa006501.66620363
22Renin secretion_Homo sapiens_hsa049241.63178956
23Calcium signaling pathway_Homo sapiens_hsa040201.62797336
24Alzheimers disease_Homo sapiens_hsa050101.61354197
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55138519
26Cholinergic synapse_Homo sapiens_hsa047251.52722702
27Carbon metabolism_Homo sapiens_hsa012001.52576998
28Dopaminergic synapse_Homo sapiens_hsa047281.51158270
29Glutamatergic synapse_Homo sapiens_hsa047241.50621039
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45819957
31Oxytocin signaling pathway_Homo sapiens_hsa049211.45565667
32Fatty acid metabolism_Homo sapiens_hsa012121.44658425
33Long-term potentiation_Homo sapiens_hsa047201.44375516
34Nitrogen metabolism_Homo sapiens_hsa009101.43416775
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43312827
36Synaptic vesicle cycle_Homo sapiens_hsa047211.35144369
37Arginine biosynthesis_Homo sapiens_hsa002201.34861740
38Insulin secretion_Homo sapiens_hsa049111.30343078
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26689180
40Gastric acid secretion_Homo sapiens_hsa049711.25138357
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24276202
42Pyruvate metabolism_Homo sapiens_hsa006201.22329956
43Salivary secretion_Homo sapiens_hsa049701.20167923
44Fructose and mannose metabolism_Homo sapiens_hsa000511.15265761
45Huntingtons disease_Homo sapiens_hsa050161.13609497
46Gap junction_Homo sapiens_hsa045401.10387898
47Taste transduction_Homo sapiens_hsa047421.05292573
48cAMP signaling pathway_Homo sapiens_hsa040241.04462888
49Regulation of autophagy_Homo sapiens_hsa041401.02534899
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01708388
51Tight junction_Homo sapiens_hsa045301.01456704
52Glucagon signaling pathway_Homo sapiens_hsa049221.01016022
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00338577
54Serotonergic synapse_Homo sapiens_hsa047260.91293794
55* PPAR signaling pathway_Homo sapiens_hsa033200.91252276
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89809972
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.87902021
58GnRH signaling pathway_Homo sapiens_hsa049120.86246343
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85884488
60Pentose phosphate pathway_Homo sapiens_hsa000300.85752401
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81504244
62beta-Alanine metabolism_Homo sapiens_hsa004100.81031964
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79088321
64Bile secretion_Homo sapiens_hsa049760.78166790
65Type II diabetes mellitus_Homo sapiens_hsa049300.77603575
66Insulin signaling pathway_Homo sapiens_hsa049100.77189536
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76554607
68Biosynthesis of amino acids_Homo sapiens_hsa012300.74713874
69Tyrosine metabolism_Homo sapiens_hsa003500.74330704
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73079143
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72726324
72Starch and sucrose metabolism_Homo sapiens_hsa005000.72041943
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.69555063
74Long-term depression_Homo sapiens_hsa047300.69499021
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64988660
76Lysine degradation_Homo sapiens_hsa003100.64772251
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63042777
78Tryptophan metabolism_Homo sapiens_hsa003800.61841996
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60755650
80Insulin resistance_Homo sapiens_hsa049310.58867680
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58815437
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58777757
83Fatty acid biosynthesis_Homo sapiens_hsa000610.57378058
84* Adipocytokine signaling pathway_Homo sapiens_hsa049200.57037103
85Fatty acid elongation_Homo sapiens_hsa000620.56042609
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55411115
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51832869
88Melanogenesis_Homo sapiens_hsa049160.51228022
89Peroxisome_Homo sapiens_hsa041460.50757442
90Circadian rhythm_Homo sapiens_hsa047100.49707339
91Axon guidance_Homo sapiens_hsa043600.47469552
92Inositol phosphate metabolism_Homo sapiens_hsa005620.45093292
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44877235
94Focal adhesion_Homo sapiens_hsa045100.42131300
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41478798
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41181084
97Phenylalanine metabolism_Homo sapiens_hsa003600.40803830
98Estrogen signaling pathway_Homo sapiens_hsa049150.40051675
99AMPK signaling pathway_Homo sapiens_hsa041520.39984293
100Arginine and proline metabolism_Homo sapiens_hsa003300.38159356
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38155959
102Ovarian steroidogenesis_Homo sapiens_hsa049130.36713084
103Protein export_Homo sapiens_hsa030600.36579923
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36075126
105Vibrio cholerae infection_Homo sapiens_hsa051100.35887788
106Phototransduction_Homo sapiens_hsa047440.35862370
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35577902
108Pancreatic secretion_Homo sapiens_hsa049720.34017900
109Glioma_Homo sapiens_hsa052140.33684199
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.32347436
111Galactose metabolism_Homo sapiens_hsa000520.31901629
112Rap1 signaling pathway_Homo sapiens_hsa040150.31511608
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30857005
114Collecting duct acid secretion_Homo sapiens_hsa049660.30122381
115* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28674481
116Glycerolipid metabolism_Homo sapiens_hsa005610.27992010

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