RXRB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.83355344
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.83355344
3DNA unwinding involved in DNA replication (GO:0006268)4.42594844
4positive regulation of histone deacetylation (GO:0031065)4.37525449
5pentose-phosphate shunt (GO:0006098)4.32609584
6regulation of translational fidelity (GO:0006450)4.09002554
7antigen processing and presentation of endogenous antigen (GO:0019883)4.08950387
8negative regulation of cell size (GO:0045792)3.92514603
9negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.82487547
10negative regulation of erythrocyte differentiation (GO:0045647)3.82068450
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.70654884
12mitotic G1 DNA damage checkpoint (GO:0031571)3.68656166
13regulation of gamma-delta T cell differentiation (GO:0045586)3.64856567
14NADPH regeneration (GO:0006740)3.61054871
15positive regulation of protein deacetylation (GO:0090312)3.50229825
16negative regulation of RNA splicing (GO:0033119)3.46148873
17folic acid-containing compound biosynthetic process (GO:0009396)3.38579736
18peptidyl-lysine dimethylation (GO:0018027)3.37283116
19detection of bacterium (GO:0016045)3.32860260
20regulation of translational termination (GO:0006449)3.32117521
21negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.30031057
22detection of other organism (GO:0098543)3.29759993
23viral transcription (GO:0019083)3.28797092
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.28616936
25negative regulation of cell killing (GO:0031342)3.28616936
26positive regulation of B cell differentiation (GO:0045579)3.26162470
27protein localization to endosome (GO:0036010)3.25746987
28positive regulation by symbiont of host defense response (GO:0052509)3.22049342
29modulation by symbiont of host defense response (GO:0052031)3.22049342
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.22049342
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.22049342
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.22049342
33modulation by symbiont of host immune response (GO:0052553)3.22049342
343-UTR-mediated mRNA stabilization (GO:0070935)3.14158930
35regulation of ARF protein signal transduction (GO:0032012)3.12365880
36heterochromatin organization (GO:0070828)3.09721940
372-oxoglutarate metabolic process (GO:0006103)3.09587526
38translational termination (GO:0006415)3.06735054
39response to muramyl dipeptide (GO:0032495)3.06332837
40antigen processing and presentation via MHC class Ib (GO:0002475)3.04830322
41positive thymic T cell selection (GO:0045059)3.04350697
42mitotic G1/S transition checkpoint (GO:0044819)3.04186535
43cellular hyperosmotic response (GO:0071474)3.04070234
44regulation of fatty acid beta-oxidation (GO:0031998)3.01512452
45negative regulation of mRNA processing (GO:0050686)3.01294014
46translational elongation (GO:0006414)2.99703804
47positive regulation of gamma-delta T cell activation (GO:0046645)2.97712720
48regulation of extracellular matrix disassembly (GO:0010715)2.97235482
49oxaloacetate metabolic process (GO:0006107)2.96297380
50tricarboxylic acid metabolic process (GO:0072350)2.96094278
51regulation of ARF GTPase activity (GO:0032312)2.95823184
52glycine metabolic process (GO:0006544)2.95708466
53regulation of cholesterol homeostasis (GO:2000188)2.95428307
54intracellular estrogen receptor signaling pathway (GO:0030520)2.95088630
55response to laminar fluid shear stress (GO:0034616)2.93508626
56regulation of gamma-delta T cell activation (GO:0046643)2.92220392
57* maternal placenta development (GO:0001893)2.90836859
58protein localization to kinetochore (GO:0034501)2.90095066
59negative regulation of mRNA metabolic process (GO:1903312)2.88630995
60G1 DNA damage checkpoint (GO:0044783)2.87242403
61positive regulation of triglyceride biosynthetic process (GO:0010867)2.86937440
62valine metabolic process (GO:0006573)2.86811478
63positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86768016
64positive regulation of lamellipodium assembly (GO:0010592)2.86722251
65negative regulation of necroptotic process (GO:0060546)2.85978783
66lysine catabolic process (GO:0006554)2.84589805
67lysine metabolic process (GO:0006553)2.84589805
68signal complex assembly (GO:0007172)2.84540357
69pre-miRNA processing (GO:0031054)2.83354946
70negative regulation of gene expression, epigenetic (GO:0045814)2.81528261
71leukocyte aggregation (GO:0070486)2.81368281
72natural killer cell differentiation (GO:0001779)2.81143208
73negative regulation of nucleotide catabolic process (GO:0030812)2.81086385
74response to peptidoglycan (GO:0032494)2.80591043
75regulation of leukocyte degranulation (GO:0043300)2.80320368
76regulation of necroptotic process (GO:0060544)2.80139225
77peptidyl-arginine omega-N-methylation (GO:0035247)2.79842295
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.79735552
79alpha-linolenic acid metabolic process (GO:0036109)2.79504616
80negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.78880794
81cellular response to interleukin-4 (GO:0071353)2.78087295
82regulation of erythrocyte differentiation (GO:0045646)2.77379878
83detection of external biotic stimulus (GO:0098581)2.76396744
84modulation by symbiont of host cellular process (GO:0044068)2.75058636
85macrophage activation involved in immune response (GO:0002281)2.73935964
86barbed-end actin filament capping (GO:0051016)2.73240127
87glucose catabolic process (GO:0006007)2.73236817
88NIK/NF-kappaB signaling (GO:0038061)2.70127799
89L-serine metabolic process (GO:0006563)2.69793061
90stress fiber assembly (GO:0043149)2.68766737
91negative regulation of histone methylation (GO:0031061)2.68410905
92COPI coating of Golgi vesicle (GO:0048205)2.68113198
93Golgi transport vesicle coating (GO:0048200)2.68113198
94megakaryocyte development (GO:0035855)2.67783308
95regulation of myeloid leukocyte mediated immunity (GO:0002886)2.67143283
96RNA stabilization (GO:0043489)2.66749325
97mRNA stabilization (GO:0048255)2.66749325
98ribosomal small subunit assembly (GO:0000028)2.65256361
99germinal center formation (GO:0002467)2.63418886
100DNA duplex unwinding (GO:0032508)2.63213961
101modulation by virus of host process (GO:0019054)2.63208884
102regulation of chromatin binding (GO:0035561)2.63159951
103regulation of T-helper 2 cell differentiation (GO:0045628)2.61671185
104negative regulation of phagocytosis (GO:0050765)2.61407025
105mannose metabolic process (GO:0006013)2.59387301
106regulation of mast cell degranulation (GO:0043304)2.57353634
107serine family amino acid biosynthetic process (GO:0009070)2.56167382
108DNA geometric change (GO:0032392)2.55971687
109negative regulation of leukocyte mediated immunity (GO:0002704)2.55793260
110ncRNA 3-end processing (GO:0043628)2.55297673
111regulation of early endosome to late endosome transport (GO:2000641)2.55162020
112negative regulation of lymphocyte mediated immunity (GO:0002707)2.53621985
113B cell receptor signaling pathway (GO:0050853)2.53372684
114IMP metabolic process (GO:0046040)2.51637922
115G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.50222572
116regulation of B cell differentiation (GO:0045577)2.50210061
117formation of translation preinitiation complex (GO:0001731)2.49571918
118regulation of necrotic cell death (GO:0010939)2.49122265
119positive regulation of nuclease activity (GO:0032075)2.48600230
120translational initiation (GO:0006413)2.47744544
121protein-DNA complex disassembly (GO:0032986)2.47592318
122nucleosome disassembly (GO:0006337)2.47592318
123chromatin silencing (GO:0006342)2.46857380
124positive regulation of cellular amide metabolic process (GO:0034250)2.46361148
125positive regulation of gene expression, epigenetic (GO:0045815)2.46160571
126response to interleukin-4 (GO:0070670)2.45745084
127positive regulation of Cdc42 GTPase activity (GO:0043089)2.45372667
128thymic T cell selection (GO:0045061)2.45000152
129negative regulation of toll-like receptor signaling pathway (GO:0034122)2.44409255
130negative regulation of type 2 immune response (GO:0002829)2.44341377
131positive regulation of extracellular matrix organization (GO:1903055)2.44133136
132glucocorticoid receptor signaling pathway (GO:0042921)2.43321255
133activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42627850
134negative regulation of necrotic cell death (GO:0060547)2.42542525
135T cell selection (GO:0045058)2.42399244
136positive regulation of lamellipodium organization (GO:1902745)2.42131942
137negative regulation of cholesterol transport (GO:0032375)2.41869950
138negative regulation of sterol transport (GO:0032372)2.41869950
139IMP biosynthetic process (GO:0006188)2.40929075
140regulation of regulated secretory pathway (GO:1903305)2.40771206
141epithelial cell differentiation involved in prostate gland development (GO:0060742)2.40315317
1424-hydroxyproline metabolic process (GO:0019471)2.40124870
143dosage compensation (GO:0007549)2.39851430
144detection of biotic stimulus (GO:0009595)2.39239957
145pinocytosis (GO:0006907)2.38656836
146positive regulation of Rap GTPase activity (GO:0032854)2.38025223
147sodium ion export (GO:0071436)2.37871218
148DNA strand elongation involved in DNA replication (GO:0006271)2.37841300
149positive regulation of receptor recycling (GO:0001921)2.37435749
150negative regulation of purine nucleotide catabolic process (GO:0033122)2.35899165
151activation of JUN kinase activity (GO:0007257)2.35361195
152regulation of interferon-beta biosynthetic process (GO:0045357)2.35356054
153negative thymic T cell selection (GO:0045060)2.35096639
154regulation of amyloid precursor protein catabolic process (GO:1902991)2.34948245
155positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.33782506
156detection of molecule of bacterial origin (GO:0032490)2.33121285
157regulation of defense response to virus by virus (GO:0050690)2.32175785
158negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.31816195
159apoptotic process involved in morphogenesis (GO:0060561)2.29906349
160retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.29620452
161positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.29387365
162protein retention in ER lumen (GO:0006621)2.29041692
163regulation of type I interferon-mediated signaling pathway (GO:0060338)2.28695500
164positive regulation of protein dephosphorylation (GO:0035307)2.28313448
165regulation of macrophage cytokine production (GO:0010935)2.28114173
166cellular response to virus (GO:0098586)2.27461679
167focal adhesion assembly (GO:0048041)2.25740625
168cell-substrate adherens junction assembly (GO:0007045)2.25740625
169regulation of extracellular matrix organization (GO:1903053)2.25514179
170activation of Rac GTPase activity (GO:0032863)2.25396855
171lipopolysaccharide-mediated signaling pathway (GO:0031663)2.24615816
172positive T cell selection (GO:0043368)2.23386525
173negative regulation of interleukin-12 production (GO:0032695)2.20572821
174embryonic process involved in female pregnancy (GO:0060136)2.20006543
175hypotonic response (GO:0006971)2.19355900
176adherens junction assembly (GO:0034333)2.17318844
177regulation of B cell receptor signaling pathway (GO:0050855)2.17057597
178maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.17010352
179positive regulation of myotube differentiation (GO:0010831)2.16753682
180regulation of dendritic cell antigen processing and presentation (GO:0002604)2.16604755
181cytoskeletal anchoring at plasma membrane (GO:0007016)2.16116645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.87602965
2MYC_22102868_ChIP-Seq_BL_Human3.85852717
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.19804699
4VDR_21846776_ChIP-Seq_THP-1_Human3.15105945
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45346311
6TCF7_22412390_ChIP-Seq_EML_Mouse2.41281604
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.37350362
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.36036743
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.31970927
10* ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.30270828
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29915887
12KDM2B_26808549_Chip-Seq_DND41_Human2.23618947
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.20840154
14LXR_22292898_ChIP-Seq_THP-1_Human2.19814733
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18489816
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16028324
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.02593878
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.97554116
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96904388
20SCL_19346495_ChIP-Seq_HPC-7_Human1.92554597
21* CIITA_25753668_ChIP-Seq_RAJI_Human1.91325077
22MAF_26560356_Chip-Seq_TH1_Human1.89796365
23UTX_26944678_Chip-Seq_JUKART_Human1.78292957
24* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.74439517
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.74393144
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74339502
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.71522392
28ZNF263_19887448_ChIP-Seq_K562_Human1.69584094
29VDR_24763502_ChIP-Seq_THP-1_Human1.65538004
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.62123938
31* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61678648
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59224276
33* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57897365
34* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57373004
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.56758915
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56516897
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56222915
38* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55923271
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.52290987
40RACK7_27058665_Chip-Seq_MCF-7_Human1.51081878
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50870075
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48948420
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48428723
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47351374
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46069434
46MAF_26560356_Chip-Seq_TH2_Human1.42459623
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41971852
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40821428
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40110489
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39692069
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39525482
52CLOCK_20551151_ChIP-Seq_293T_Human1.37781262
53P68_20966046_ChIP-Seq_HELA_Human1.37492830
54SMC4_20622854_ChIP-Seq_HELA_Human1.37141968
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.36490589
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35710511
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35577546
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.34194884
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34037801
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33309056
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.32966279
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31808355
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31513181
64XRN2_22483619_ChIP-Seq_HELA_Human1.29893092
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28176160
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27952530
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26906185
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.26887375
69GATA1_22025678_ChIP-Seq_K562_Human1.26335946
70* NCOR1_26117541_ChIP-Seq_K562_Human1.26225273
71* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24266326
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23492274
73BCOR_27268052_Chip-Seq_Bcells_Human1.23305433
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.22288640
75MYB_26560356_Chip-Seq_TH1_Human1.21279665
76* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21232183
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20178718
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19987443
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19391167
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19328671
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18692942
82* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18445706
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17667078
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17631019
85* SPI1_23127762_ChIP-Seq_K562_Human1.16523104
86BCL6_27268052_Chip-Seq_Bcells_Human1.16457824
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16445768
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16148380
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14554156
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14113802
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.14080073
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13693681
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12386733
94ATF3_27146783_Chip-Seq_COLON_Human1.12252635
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11585921
96CREB1_26743006_Chip-Seq_LNCaP_Human1.11137525
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10780999
98* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10727569
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10158940
100TET1_21451524_ChIP-Seq_MESCs_Mouse1.10034781
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09731162
102KDM2B_26808549_Chip-Seq_K562_Human1.09563288
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09463330
104KDM5A_27292631_Chip-Seq_BREAST_Human1.08091214
105CTCF_21964334_Chip-Seq_Bcells_Human1.07982229
106IRF8_27001747_Chip-Seq_BMDM_Mouse1.07812794
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07013657
108MYB_26560356_Chip-Seq_TH2_Human1.06174394
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05583438
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05452913
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05345814
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05121979
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03914480
114ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03836829
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03745389
116RUNX_20019798_ChIP-Seq_JUKART_Human1.03647474
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03327594
118* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03149218
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03105117
120MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02138294
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01829900
122PHF8_20622854_ChIP-Seq_HELA_Human1.01607962
123SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01374734
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01229768
125* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00606286
126CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99306824
127E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98225935
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98040990
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97917173
130RUNX1_27514584_Chip-Seq_MCF-7_Human0.97524547
131CTCF_27219007_Chip-Seq_Bcells_Human0.96396760
132SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95718335
133FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95611523
134* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95542251
135GATA1_19941826_ChIP-Seq_K562_Human0.94738656
136TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94526354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.00052323
2MP0003705_abnormal_hypodermis_morpholog2.97573162
3MP0003303_peritoneal_inflammation2.87123177
4MP0009278_abnormal_bone_marrow2.83984659
5MP0009840_abnormal_foam_cell2.80037034
6MP0005451_abnormal_body_composition2.67695163
7MP0008260_abnormal_autophagy2.42845577
8MP0008961_abnormal_basal_metabolism2.40666580
9MP0010352_gastrointestinal_tract_polyps2.39503201
10MP0005360_urolithiasis2.26778314
11MP0001545_abnormal_hematopoietic_system2.19241867
12MP0005397_hematopoietic_system_phenotyp2.19241867
13MP0008438_abnormal_cutaneous_collagen2.13643916
14MP0003724_increased_susceptibility_to2.04807450
15MP0003300_gastrointestinal_ulcer2.02489190
16MP0004808_abnormal_hematopoietic_stem2.02248844
17MP0000685_abnormal_immune_system1.95914111
18MP0002419_abnormal_innate_immunity1.93282352
19MP0004185_abnormal_adipocyte_glucose1.86473604
20MP0005025_abnormal_response_to1.86088074
21MP0003329_amyloid_beta_deposits1.82040187
22MP0002139_abnormal_hepatobiliary_system1.78364181
23MP0005000_abnormal_immune_tolerance1.76890269
24MP0001958_emphysema1.76627135
25MP0004947_skin_inflammation1.73220541
26MP0003279_aneurysm1.71356052
27MP0001533_abnormal_skeleton_physiology1.71199926
28* MP0003191_abnormal_cellular_cholesterol1.70934831
29MP0003172_abnormal_lysosome_physiology1.69212240
30MP0002398_abnormal_bone_marrow1.68343729
31MP0010234_abnormal_vibrissa_follicle1.66252871
32MP0000858_altered_metastatic_potential1.66196177
33MP0003091_abnormal_cell_migration1.64774466
34MP0005076_abnormal_cell_differentiation1.62820630
35MP0005464_abnormal_platelet_physiology1.61585365
36MP0005085_abnormal_gallbladder_physiolo1.60156032
37MP0003763_abnormal_thymus_physiology1.59175351
38MP0004130_abnormal_muscle_cell1.52174508
39MP0003111_abnormal_nucleus_morphology1.52135639
40MP0000689_abnormal_spleen_morphology1.51698916
41MP0005365_abnormal_bile_salt1.51061133
42MP0005409_darkened_coat_color1.50891601
43MP0003656_abnormal_erythrocyte_physiolo1.50732901
44MP0002722_abnormal_immune_system1.50347163
45MP0000747_muscle_weakness1.48901497
46MP0005666_abnormal_adipose_tissue1.44882335
47MP0010329_abnormal_lipoprotein_level1.44666136
48MP0003183_abnormal_peptide_metabolism1.43017222
49MP0001730_embryonic_growth_arrest1.42326642
50MP0000703_abnormal_thymus_morphology1.42116725
51MP0004957_abnormal_blastocyst_morpholog1.41255266
52MP0000609_abnormal_liver_physiology1.39702881
53MP0002877_abnormal_melanocyte_morpholog1.38739765
54MP0003828_pulmonary_edema1.37001423
55MP0002269_muscular_atrophy1.36785269
56MP0001800_abnormal_humoral_immune1.36685127
57MP0002998_abnormal_bone_remodeling1.33457677
58MP0000604_amyloidosis1.33119673
59MP0002429_abnormal_blood_cell1.29725279
60MP0000465_gastrointestinal_hemorrhage1.29513405
61MP0003690_abnormal_glial_cell1.28213115
62MP0006082_CNS_inflammation1.28195872
63MP0000716_abnormal_immune_system1.27624420
64MP0001849_ear_inflammation1.26975883
65MP0003075_altered_response_to1.25319066
66MP0005083_abnormal_biliary_tract1.25008020
67MP0003453_abnormal_keratinocyte_physiol1.24682773
68MP0001873_stomach_inflammation1.24334301
69MP0002933_joint_inflammation1.22572595
70MP0009785_altered_susceptibility_to1.21860966
71MP0006036_abnormal_mitochondrial_physio1.20713825
72MP0004087_abnormal_muscle_fiber1.19697029
73MP0004859_abnormal_synaptic_plasticity1.19225474
74MP0002166_altered_tumor_susceptibility1.18403953
75MP0005375_adipose_tissue_phenotype1.18128252
76MP0004510_myositis1.17055980
77MP0003077_abnormal_cell_cycle1.16283839
78MP0000490_abnormal_crypts_of1.15392158
79MP0003221_abnormal_cardiomyocyte_apopto1.15308282
80MP0002019_abnormal_tumor_incidence1.14945523
81MP0008770_decreased_survivor_rate1.12307622
82MP0004858_abnormal_nervous_system1.11870212
83MP0005023_abnormal_wound_healing1.10553254
84MP0010630_abnormal_cardiac_muscle1.09848669
85MP0001851_eye_inflammation1.09759915
86MP0003436_decreased_susceptibility_to1.09038634
87MP0002420_abnormal_adaptive_immunity1.08717834
88MP0000350_abnormal_cell_proliferation1.08125723
89MP0003866_abnormal_defecation1.07962206
90MP0010307_abnormal_tumor_latency1.07814721
91MP0002822_catalepsy1.06716971
92MP0000598_abnormal_liver_morphology1.06637589
93* MP0002080_prenatal_lethality1.06254258
94MP0005330_cardiomyopathy1.06230979
95MP0003879_abnormal_hair_cell1.05573555
96MP0000003_abnormal_adipose_tissue1.04946662
97MP0001819_abnormal_immune_cell1.04778993
98MP0000751_myopathy1.04070874
99MP0005319_abnormal_enzyme/_coenzyme1.03880466
100MP0005584_abnormal_enzyme/coenzyme_acti1.03380940
101MP0005671_abnormal_response_to1.03011945
102MP0005166_decreased_susceptibility_to1.02551625
103MP0010094_abnormal_chromosome_stability1.02516298
104MP0002452_abnormal_antigen_presenting1.00086491
105MP0004381_abnormal_hair_follicle0.99649904
106MP0005390_skeleton_phenotype0.99230528
107MP0001835_abnormal_antigen_presentation0.99113593
108MP0001348_abnormal_lacrimal_gland0.99064942
109MP0001845_abnormal_inflammatory_respons0.99033468
110MP0002723_abnormal_immune_serum0.98850446
111MP0000733_abnormal_muscle_development0.98718473
112MP0009333_abnormal_splenocyte_physiolog0.97834632
113MP0002089_abnormal_postnatal_growth/wei0.97499179
114MP0005075_abnormal_melanosome_morpholog0.97183616
115MP0002086_abnormal_extraembryonic_tissu0.95338769
116MP0001790_abnormal_immune_system0.94920991
117MP0005387_immune_system_phenotype0.94920991
118MP0002148_abnormal_hypersensitivity_rea0.94413540
119MP0000678_abnormal_parathyroid_gland0.93831641
120MP0003806_abnormal_nucleotide_metabolis0.93363850
121MP0003252_abnormal_bile_duct0.92876531
122MP0003123_paternal_imprinting0.92295859
123MP0000767_abnormal_smooth_muscle0.92295605
124MP0000759_abnormal_skeletal_muscle0.92261883
125MP0001697_abnormal_embryo_size0.92208669
126MP0003984_embryonic_growth_retardation0.92064435
127MP0009672_abnormal_birth_weight0.91974371
128MP0008875_abnormal_xenobiotic_pharmacok0.91811387
129MP0003566_abnormal_cell_adhesion0.91429123
130MP0002970_abnormal_white_adipose0.91108514
131MP0002088_abnormal_embryonic_growth/wei0.90210230
132MP0008874_decreased_physiological_sensi0.90041398
133MP0010155_abnormal_intestine_physiology0.89485097
134MP0005058_abnormal_lysosome_morphology0.88744979
135MP0000313_abnormal_cell_death0.88635388
136MP0002118_abnormal_lipid_homeostasis0.87728392
137MP0005257_abnormal_intraocular_pressure0.86953764
138MP0002132_abnormal_respiratory_system0.86763876
139MP0000920_abnormal_myelination0.85678835
140MP0002405_respiratory_system_inflammati0.85640772
141MP0001672_abnormal_embryogenesis/_devel0.85564584
142MP0005380_embryogenesis_phenotype0.85564584
143MP0003045_fibrosis0.85106952
144MP0008469_abnormal_protein_level0.84566454
145MP0004233_abnormal_muscle_weight0.83585969
146MP0002971_abnormal_brown_adipose0.79107023
147MP0000343_altered_response_to0.77355212
148MP0003448_altered_tumor_morphology0.73331675
149MP0003634_abnormal_glial_cell0.73087496
150MP0000681_abnormal_thyroid_gland0.72774471

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.88822763
2Hyperacusis (HP:0010780)3.73572353
3Abnormality of the lower motor neuron (HP:0002366)3.45929808
4Obstructive sleep apnea (HP:0002870)3.22480916
5Protrusio acetabuli (HP:0003179)3.10673030
6Abnormality of the Achilles tendon (HP:0005109)2.98870602
7Achilles tendon contracture (HP:0001771)2.98161288
8Myositis (HP:0100614)2.91876463
9Multiple enchondromatosis (HP:0005701)2.91581065
10Insomnia (HP:0100785)2.89171626
11Nasal polyposis (HP:0100582)2.84663437
12Cerebral aneurysm (HP:0004944)2.67473612
13Orchitis (HP:0100796)2.66731391
14Abnormality of the nasal mucosa (HP:0000433)2.64970208
15Abnormality of macrophages (HP:0004311)2.64199069
16Distal upper limb amyotrophy (HP:0007149)2.63237150
17Upper limb amyotrophy (HP:0009129)2.63237150
18Verrucae (HP:0200043)2.62003643
19Papilloma (HP:0012740)2.62003643
20Recurrent abscess formation (HP:0002722)2.61273291
21Deep venous thrombosis (HP:0002625)2.57992488
22Chronic otitis media (HP:0000389)2.55325327
23Supranuclear gaze palsy (HP:0000605)2.52490681
24Thrombocytosis (HP:0001894)2.52050481
25Vertebral compression fractures (HP:0002953)2.51370236
26Gastrointestinal inflammation (HP:0004386)2.50547670
27Recurrent bacterial skin infections (HP:0005406)2.46613954
28Increased variability in muscle fiber diameter (HP:0003557)2.44218060
29Spastic diplegia (HP:0001264)2.43975498
30Cellulitis (HP:0100658)2.42206841
31Broad face (HP:0000283)2.41863044
32Elfin facies (HP:0004428)2.40972596
33Gastrointestinal infarctions (HP:0005244)2.40713859
34Basal cell carcinoma (HP:0002671)2.38515362
35Cervical subluxation (HP:0003308)2.38042847
36Dysostosis multiplex (HP:0000943)2.36857661
37Colitis (HP:0002583)2.33225110
38Hand muscle atrophy (HP:0009130)2.31243224
39Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.31109546
40Recurrent gram-negative bacterial infections (HP:0005420)2.30582792
41Annular pancreas (HP:0001734)2.27476163
42Abnormality of skeletal muscle fiber size (HP:0012084)2.27448113
43Impaired platelet aggregation (HP:0003540)2.26817559
44Abnormal platelet function (HP:0011869)2.26817559
45Hemorrhage of the eye (HP:0011885)2.26097575
46Ependymoma (HP:0002888)2.24873087
47Gingivitis (HP:0000230)2.24341459
48Progressive muscle weakness (HP:0003323)2.23598717
49Chronic obstructive pulmonary disease (HP:0006510)2.23067017
50Obstructive lung disease (HP:0006536)2.23067017
51Premature rupture of membranes (HP:0001788)2.22392678
52Overriding aorta (HP:0002623)2.22368464
53Myoglobinuria (HP:0002913)2.20764847
54Retrobulbar optic neuritis (HP:0100654)2.20689687
55Optic neuritis (HP:0100653)2.20689687
56Centrally nucleated skeletal muscle fibers (HP:0003687)2.20298513
57Inflammation of the large intestine (HP:0002037)2.20115548
58Distal lower limb amyotrophy (HP:0008944)2.19838915
59IgM deficiency (HP:0002850)2.18318717
60Neurofibrillary tangles (HP:0002185)2.17445962
61Angiofibromas (HP:0010615)2.16369936
62Adenoma sebaceum (HP:0009720)2.16369936
63Difficulty running (HP:0009046)2.15271558
64Abnormality of cells of the erythroid lineage (HP:0012130)2.15067158
65Renovascular hypertension (HP:0100817)2.12510807
66Amyloidosis (HP:0011034)2.12382674
67Segmental peripheral demyelination/remyelination (HP:0003481)2.10170796
68Ragged-red muscle fibers (HP:0003200)2.09972208
69Pseudobulbar signs (HP:0002200)2.09148269
70Ketosis (HP:0001946)2.08901928
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.08801454
72Dilatation of the ascending aorta (HP:0005111)2.07925912
73Reticulocytosis (HP:0001923)2.07596293
74Peritonitis (HP:0002586)2.06341166
75Abnormal number of erythroid precursors (HP:0012131)2.05614837
76Polycythemia (HP:0001901)2.04796872
77Pointed chin (HP:0000307)2.03851685
78Mucopolysacchariduria (HP:0008155)2.03217904
79Urinary glycosaminoglycan excretion (HP:0003541)2.03217904
80Recurrent bronchitis (HP:0002837)2.02509158
81Ulnar bowing (HP:0003031)2.01583948
82Meningitis (HP:0001287)2.00497499
83Thin bony cortex (HP:0002753)1.99916513
84Emphysema (HP:0002097)1.99213090
85Aneurysm (HP:0002617)1.98887196
86Systemic lupus erythematosus (HP:0002725)1.98496884
87Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98327665
88Abnormality of polysaccharide metabolism (HP:0011012)1.98327665
89Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98327665
90Resting tremor (HP:0002322)1.98182564
91Distal lower limb muscle weakness (HP:0009053)1.97428881
92Hypercortisolism (HP:0001578)1.97006576
93Mediastinal lymphadenopathy (HP:0100721)1.96866885
94Cerebral inclusion bodies (HP:0100314)1.96750604
95Neuronal loss in central nervous system (HP:0002529)1.96141581
96Myopathic facies (HP:0002058)1.95992980
97Purpura (HP:0000979)1.95893858
98Hypochromic anemia (HP:0001931)1.94332324
99Prolonged bleeding time (HP:0003010)1.93086666
100Recurrent viral infections (HP:0004429)1.93008134
101Polygenic inheritance (HP:0010982)1.92990463
102Asymmetric septal hypertrophy (HP:0001670)1.92771686
103Late onset (HP:0003584)1.91730083
104Mitral regurgitation (HP:0001653)1.90739356
105Disproportionate tall stature (HP:0001519)1.90736501
106Renal duplication (HP:0000075)1.89349024
107Lymphangioma (HP:0100764)1.87938648
108Gastrointestinal stroma tumor (HP:0100723)1.87766028
109Abnormality of the fingertips (HP:0001211)1.85550608
110Axonal loss (HP:0003447)1.85101921
111Abnormality of aromatic amino acid family metabolism (HP:0004338)1.84318654
112Flat acetabular roof (HP:0003180)1.82671162
113Abnormality of the peritoneum (HP:0002585)1.81366721
114Papilledema (HP:0001085)1.81057849
115Hyperammonemia (HP:0001987)1.80572308
116Arterial tortuosity (HP:0005116)1.79097361
117Elevated erythrocyte sedimentation rate (HP:0003565)1.77567989
118Metaphyseal cupping (HP:0003021)1.77376986
119Loss of speech (HP:0002371)1.77225962
120High pitched voice (HP:0001620)1.77110768
121Panhypogammaglobulinemia (HP:0003139)1.75954451
122Difficulty climbing stairs (HP:0003551)1.75769564
123Vascular tortuosity (HP:0004948)1.75499484
124Growth hormone excess (HP:0000845)1.74737959
125Increased density of long bones (HP:0006392)1.74007699
126Onion bulb formation (HP:0003383)1.73792909
127Stridor (HP:0010307)1.73749414
128Increased IgE level (HP:0003212)1.72330174
129Exercise-induced muscle cramps (HP:0003710)1.72192347
130Abnormality of reticulocytes (HP:0004312)1.72148509
131Type 1 muscle fiber predominance (HP:0003803)1.71820112
132Limb-girdle muscle atrophy (HP:0003797)1.71729356
133Aortic aneurysm (HP:0004942)1.71659335
134EMG: neuropathic changes (HP:0003445)1.71622361
135Increased serum ferritin (HP:0003281)1.70319388
136Abnormality of complement system (HP:0005339)1.70304474
137Chest pain (HP:0100749)1.70296030
138Slow saccadic eye movements (HP:0000514)1.69596331
139Dysmetric saccades (HP:0000641)1.69515079
140Recurrent fungal infections (HP:0002841)1.69409043
141Exercise-induced myalgia (HP:0003738)1.69321808
142Fatigue (HP:0012378)1.68846361
143Abnormality of the thoracic spine (HP:0100711)1.67973286
144Hypertensive crisis (HP:0100735)1.67028336
145Spondylolisthesis (HP:0003302)1.66691096
146Fibroma (HP:0010614)1.66400733
147Interstitial pulmonary disease (HP:0006530)1.66132352
148Abnormality of T cell physiology (HP:0011840)1.65839283
149Prominent nose (HP:0000448)1.65799284
150Blue sclerae (HP:0000592)1.65352719
151Rapidly progressive (HP:0003678)1.64872883
152Ulnar deviation of the wrist (HP:0003049)1.64861770
153Abnormal cartilage morphology (HP:0002763)1.64225040
154Ketoacidosis (HP:0001993)1.64112198
155Syringomyelia (HP:0003396)1.63952969
156Spinal cord lesions (HP:0100561)1.63952969
157Neonatal onset (HP:0003623)1.63784926
158Recurrent skin infections (HP:0001581)1.63577887
159Increased connective tissue (HP:0009025)1.63454213
160Vasculitis (HP:0002633)1.63424907
161Biconcave vertebral bodies (HP:0004586)1.63362445
162Rectal prolapse (HP:0002035)1.63271652
163Genu recurvatum (HP:0002816)1.62488880
164Abnormal platelet volume (HP:0011876)1.61629520
165Mitral valve prolapse (HP:0001634)1.61340962
166Spontaneous hematomas (HP:0007420)1.60878985
167Xanthomatosis (HP:0000991)1.60439708
168Epistaxis (HP:0000421)1.60058381
169Gout (HP:0001997)1.57510400
170Global brain atrophy (HP:0002283)1.57060235
171Selective tooth agenesis (HP:0001592)1.56727329
172Fibrous tissue neoplasm (HP:0012316)1.56379819
173Rhabdomyolysis (HP:0003201)1.55825474
174Abnormality of T cells (HP:0002843)1.55280706
175Petechiae (HP:0000967)1.53872263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.69345191
2PKN24.45547190
3EEF2K4.32879120
4MAP3K103.75826852
5PRPF4B3.47858094
6ERN12.98025699
7MAP4K12.83413891
8RIPK42.53517508
9GRK62.49277216
10FLT32.13966900
11SMG11.94470688
12BCKDK1.92291666
13MAP3K131.82963933
14CDK121.78000595
15SIK31.70584703
16ICK1.67399256
17SCYL21.67086195
18LRRK21.57467563
19PTK61.54264956
20TTN1.42336224
21RIPK11.41316959
22ALK1.37997818
23TAOK11.35593783
24CSF1R1.35477770
25SIK21.29331625
26NEK21.28653008
27MAP3K11.26751927
28MAP2K31.26063743
29PAK41.25347253
30IRAK41.22911237
31IRAK31.22496930
32STK101.20654017
33TYRO31.16667429
34MAP3K111.13871857
35CDC42BPA1.13438989
36MAP3K31.13189349
37CDK41.11532424
38PRKD21.10731728
39BTK1.09007508
40MAP3K71.06808070
41TAOK21.06452796
42SIK11.06273065
43MAPKAPK31.05973139
44ARAF1.05619339
45MAP3K141.04786852
46DAPK11.02473574
47RPS6KB21.01287511
48FES0.99869368
49KSR20.98400165
50ZAP700.98113938
51TESK10.97510848
52JAK30.97179346
53PDGFRA0.96579300
54CAMKK10.91580595
55MATK0.91419597
56KIT0.90688754
57FGFR40.89230263
58JAK10.89191175
59MAP3K80.86161873
60MAPK110.82587689
61TYK20.81280686
62DDR20.79892160
63WEE10.79577741
64TGFBR20.79512207
65STK380.79039412
66CLK10.76847534
67FGFR30.76628431
68HCK0.75818259
69NEK10.75389297
70TNK20.74346765
71HIPK20.71411807
72MTOR0.70923475
73MAP3K90.70587098
74BMX0.70573999
75CDC70.69630065
76SYK0.69457940
77MAPK70.66974527
78EPHB10.65815142
79JAK20.64731193
80ITK0.62608621
81RET0.62243054
82NTRK10.62216166
83PDK10.61279566
84CSK0.60986701
85ILK0.60944630
86TESK20.60680589
87BLK0.60449230
88TBK10.60399758
89CDK60.57818293
90MOS0.55058900
91MARK20.53182111
92UHMK10.53162455
93DYRK1B0.52297365
94CAMK1D0.52279325
95PAK20.51766133
96MAP3K60.51634923
97SGK30.51419244
98KDR0.51162729
99PASK0.50701429
100MAP3K20.50527013
101MAP2K20.49785145
102AKT20.49327865
103DAPK30.49188943
104FGR0.49034629
105BRSK10.48697901
106PIM10.48096334
107DAPK20.47975710
108PRKCH0.47688925
109PAK60.47326126
110LCK0.46356856
111CAMK1G0.45522642
112RPS6KL10.45207772
113RPS6KC10.45207772
114PDGFRB0.45145189
115PTK20.44872837
116FYN0.44633789
117IKBKE0.44490850
118MAP2K60.44417215
119CDK70.44340758
120DYRK30.43923472
121PDPK10.43819295
122RPS6KA10.43782580
123MAPK120.43433703
124RPS6KA60.43143796
125STK110.42878621
126MARK30.41986903
127CAMK40.41742635
128RPS6KA20.41278624
129MAPK40.40243468
130PRKD30.39406392
131MAP2K40.39402422
132NEK90.38729551
133LYN0.37916388
134PRKD10.37740582
135NME20.37479680
136CDK190.37203856
137STK40.35091057

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.23200250
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97044018
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.82676406
4Other glycan degradation_Homo sapiens_hsa005112.42329944
5DNA replication_Homo sapiens_hsa030302.19013137
6Sulfur relay system_Homo sapiens_hsa041222.18219227
7B cell receptor signaling pathway_Homo sapiens_hsa046622.07336578
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.02384981
9Biosynthesis of amino acids_Homo sapiens_hsa012301.98040398
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97050402
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.82247557
12Arginine biosynthesis_Homo sapiens_hsa002201.75912703
13Chronic myeloid leukemia_Homo sapiens_hsa052201.69152258
14Carbon metabolism_Homo sapiens_hsa012001.62786821
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.61430966
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58032924
17Central carbon metabolism in cancer_Homo sapiens_hsa052301.56166872
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55597374
19Acute myeloid leukemia_Homo sapiens_hsa052211.54026584
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.47459014
21Lysine degradation_Homo sapiens_hsa003101.46846634
22mTOR signaling pathway_Homo sapiens_hsa041501.43946402
23Staphylococcus aureus infection_Homo sapiens_hsa051501.41447231
24VEGF signaling pathway_Homo sapiens_hsa043701.41008758
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40203340
26Primary immunodeficiency_Homo sapiens_hsa053401.38330703
27* Non-small cell lung cancer_Homo sapiens_hsa052231.37011535
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35824769
29Fatty acid degradation_Homo sapiens_hsa000711.34707531
30Pentose phosphate pathway_Homo sapiens_hsa000301.28016669
31GnRH signaling pathway_Homo sapiens_hsa049121.26904719
32Prion diseases_Homo sapiens_hsa050201.26127073
33Toxoplasmosis_Homo sapiens_hsa051451.25965766
34Tuberculosis_Homo sapiens_hsa051521.25516098
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17698841
36Insulin resistance_Homo sapiens_hsa049311.16997005
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14889680
38One carbon pool by folate_Homo sapiens_hsa006701.13930144
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11812445
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11072480
41TNF signaling pathway_Homo sapiens_hsa046681.09591395
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.08442541
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08235846
44Selenocompound metabolism_Homo sapiens_hsa004501.08035536
45Base excision repair_Homo sapiens_hsa034101.05885791
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.05403263
47Insulin signaling pathway_Homo sapiens_hsa049101.02992934
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01096845
49Long-term potentiation_Homo sapiens_hsa047201.00265716
50Influenza A_Homo sapiens_hsa051641.00099037
51Chemokine signaling pathway_Homo sapiens_hsa040620.99760233
52Hepatitis C_Homo sapiens_hsa051600.98783230
53Viral myocarditis_Homo sapiens_hsa054160.98141646
54Glioma_Homo sapiens_hsa052140.98011703
55ErbB signaling pathway_Homo sapiens_hsa040120.97818552
56Prolactin signaling pathway_Homo sapiens_hsa049170.97752913
57Malaria_Homo sapiens_hsa051440.96489449
58Mismatch repair_Homo sapiens_hsa034300.96066682
59AMPK signaling pathway_Homo sapiens_hsa041520.94939645
60Caffeine metabolism_Homo sapiens_hsa002320.94579147
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94375528
62Amoebiasis_Homo sapiens_hsa051460.93088223
63Spliceosome_Homo sapiens_hsa030400.93030378
64Choline metabolism in cancer_Homo sapiens_hsa052310.92868880
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.92722701
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91703439
67Ribosome_Homo sapiens_hsa030100.91153769
68Bile secretion_Homo sapiens_hsa049760.90538889
69Pertussis_Homo sapiens_hsa051330.88223446
70Measles_Homo sapiens_hsa051620.88161482
71Lysosome_Homo sapiens_hsa041420.87140766
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84454443
73* Adipocytokine signaling pathway_Homo sapiens_hsa049200.84187271
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83918325
75Allograft rejection_Homo sapiens_hsa053300.83217302
76Osteoclast differentiation_Homo sapiens_hsa043800.82587159
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82349793
78Fructose and mannose metabolism_Homo sapiens_hsa000510.82032783
79Notch signaling pathway_Homo sapiens_hsa043300.81859807
80Pyruvate metabolism_Homo sapiens_hsa006200.81614085
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81193290
82Focal adhesion_Homo sapiens_hsa045100.81130826
83Inositol phosphate metabolism_Homo sapiens_hsa005620.80738368
84Platelet activation_Homo sapiens_hsa046110.79865926
85Autoimmune thyroid disease_Homo sapiens_hsa053200.78670512
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.78623884
87Glucagon signaling pathway_Homo sapiens_hsa049220.78422283
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77604001
89Herpes simplex infection_Homo sapiens_hsa051680.77248135
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77093072
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76942125
92Propanoate metabolism_Homo sapiens_hsa006400.76924601
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76669672
94Graft-versus-host disease_Homo sapiens_hsa053320.76628589
95Phagosome_Homo sapiens_hsa041450.75588601
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75441221
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75404945
98Salmonella infection_Homo sapiens_hsa051320.74925242
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73945101
100Bladder cancer_Homo sapiens_hsa052190.72222681
101T cell receptor signaling pathway_Homo sapiens_hsa046600.71796594
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71166946
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.71149966
104Fatty acid metabolism_Homo sapiens_hsa012120.69183456
105Antigen processing and presentation_Homo sapiens_hsa046120.68788211
106Estrogen signaling pathway_Homo sapiens_hsa049150.67564102
107Tryptophan metabolism_Homo sapiens_hsa003800.67326884
108Colorectal cancer_Homo sapiens_hsa052100.66637420
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66471054
110HIF-1 signaling pathway_Homo sapiens_hsa040660.66436408
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66246194
112* PPAR signaling pathway_Homo sapiens_hsa033200.65492965
113FoxO signaling pathway_Homo sapiens_hsa040680.65184416
114MAPK signaling pathway_Homo sapiens_hsa040100.64099351
115Proteoglycans in cancer_Homo sapiens_hsa052050.63707220
116* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63238846
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62475092
118mRNA surveillance pathway_Homo sapiens_hsa030150.62222820
119Folate biosynthesis_Homo sapiens_hsa007900.62007675
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.61737358
121Endometrial cancer_Homo sapiens_hsa052130.61575744
122Prostate cancer_Homo sapiens_hsa052150.61486538
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.60378808
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60014578
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58531169
126Pancreatic cancer_Homo sapiens_hsa052120.58494791
127Galactose metabolism_Homo sapiens_hsa000520.56301698
128Shigellosis_Homo sapiens_hsa051310.56246139
129Viral carcinogenesis_Homo sapiens_hsa052030.56138068
130RNA transport_Homo sapiens_hsa030130.54982408
131Hematopoietic cell lineage_Homo sapiens_hsa046400.53756767
132* Small cell lung cancer_Homo sapiens_hsa052220.53577542
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.52748002
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52695569
135HTLV-I infection_Homo sapiens_hsa051660.52378440
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.51766044
137Fat digestion and absorption_Homo sapiens_hsa049750.50078489
138ABC transporters_Homo sapiens_hsa020100.49560339
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49370827
140Renal cell carcinoma_Homo sapiens_hsa052110.48193149
141Type II diabetes mellitus_Homo sapiens_hsa049300.47970282
142Leishmaniasis_Homo sapiens_hsa051400.47351119
143Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47322743
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46733602
145Apoptosis_Homo sapiens_hsa042100.46003567
146beta-Alanine metabolism_Homo sapiens_hsa004100.43914055
147Endocytosis_Homo sapiens_hsa041440.43499999
148Hepatitis B_Homo sapiens_hsa051610.43333558
149AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42462523

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