RXFP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aggressive behavior (GO:0002118)7.24224246
2regulation of female receptivity (GO:0045924)5.78501487
3regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.59723721
4neuron cell-cell adhesion (GO:0007158)5.57162703
5female mating behavior (GO:0060180)5.54313896
6presynaptic membrane assembly (GO:0097105)5.19959858
7vocalization behavior (GO:0071625)5.06024882
8positive regulation of synaptic transmission, GABAergic (GO:0032230)5.00673995
9presynaptic membrane organization (GO:0097090)4.98753997
10regulation of glutamate receptor signaling pathway (GO:1900449)4.84190736
11positive regulation of uterine smooth muscle contraction (GO:0070474)4.73502697
12drinking behavior (GO:0042756)4.57786773
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.53160807
14postsynaptic membrane organization (GO:0001941)4.47704672
15synaptic vesicle exocytosis (GO:0016079)4.37431928
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.32631155
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.30620431
18protein localization to synapse (GO:0035418)4.20500411
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.17161227
20positive regulation of synapse assembly (GO:0051965)4.15649782
21neurotransmitter-gated ion channel clustering (GO:0072578)4.10007159
22positive regulation of action potential (GO:0045760)4.02549173
23negative regulation of synaptic transmission, GABAergic (GO:0032229)4.01416250
24neuron recognition (GO:0008038)3.98059163
25regulation of glutamate secretion (GO:0014048)3.96104528
26regulation of synaptic transmission, GABAergic (GO:0032228)3.95567799
27maternal behavior (GO:0042711)3.89170985
28regulation of uterine smooth muscle contraction (GO:0070472)3.85346309
29positive regulation of amino acid transport (GO:0051957)3.84038155
30regulation of synaptic vesicle exocytosis (GO:2000300)3.82185912
31glutamate receptor signaling pathway (GO:0007215)3.78342380
32locomotory exploration behavior (GO:0035641)3.76252947
33axonal fasciculation (GO:0007413)3.65019900
34synaptic transmission, glutamatergic (GO:0035249)3.62877822
35neuronal action potential propagation (GO:0019227)3.62442592
36neuron-neuron synaptic transmission (GO:0007270)3.61965795
37positive regulation of amine transport (GO:0051954)3.60950445
38cerebral cortex radially oriented cell migration (GO:0021799)3.60766605
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.60751028
40neurotransmitter secretion (GO:0007269)3.60610991
41cellular response to ammonium ion (GO:0071242)3.58288289
42gamma-aminobutyric acid transport (GO:0015812)3.49662943
43behavioral response to ethanol (GO:0048149)3.47127848
44parental behavior (GO:0060746)3.41076508
45long-chain fatty acid biosynthetic process (GO:0042759)3.40752760
46glutamate secretion (GO:0014047)3.38952744
47response to histamine (GO:0034776)3.37281111
48synaptic vesicle maturation (GO:0016188)3.34420473
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.33360198
50regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.27457663
51regulation of synapse assembly (GO:0051963)3.26044739
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22376930
53negative regulation of neurotransmitter transport (GO:0051589)3.22370805
54exploration behavior (GO:0035640)3.19635533
55fat-soluble vitamin catabolic process (GO:0042363)3.16690829
56vitamin catabolic process (GO:0009111)3.16690829
57regulation of synaptic vesicle transport (GO:1902803)3.16396937
58multicellular organismal reproductive behavior (GO:0033057)3.15887410
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15776869
60positive regulation of neurotransmitter transport (GO:0051590)3.15399011
61positive regulation of membrane potential (GO:0045838)3.12030106
62regulation of protein kinase A signaling (GO:0010738)3.11614661
63sleep (GO:0030431)3.11536187
64neurotransmitter transport (GO:0006836)3.10996423
65response to auditory stimulus (GO:0010996)3.10944273
66layer formation in cerebral cortex (GO:0021819)3.08076775
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05839291
68regulation of respiratory system process (GO:0044065)3.05336977
69social behavior (GO:0035176)3.04246592
70intraspecies interaction between organisms (GO:0051703)3.04246592
71energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.04120084
72ATP hydrolysis coupled proton transport (GO:0015991)3.04120084
73synaptic vesicle docking involved in exocytosis (GO:0016081)3.02162261
74synapse assembly (GO:0007416)2.99465678
75regulation of excitatory postsynaptic membrane potential (GO:0060079)2.97637177
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97057435
77regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96886492
78positive regulation of digestive system process (GO:0060456)2.96162461
79proline transport (GO:0015824)2.94812199
80regulation of neurotransmitter levels (GO:0001505)2.91671228
81positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90993275
82multi-organism reproductive behavior (GO:0044705)2.90277030
83transferrin transport (GO:0033572)2.88472855
84positive regulation of synaptic transmission (GO:0050806)2.86070117
85regulation of neuronal synaptic plasticity (GO:0048168)2.86069023
86transmission of nerve impulse (GO:0019226)2.85737328
87cerebellar Purkinje cell layer development (GO:0021680)2.85176861
88regulation of synaptic transmission, glutamatergic (GO:0051966)2.84976099
89startle response (GO:0001964)2.83687082
90mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.81647964
91negative regulation of amino acid transport (GO:0051956)2.81242271
92dendrite development (GO:0016358)2.79443886
93regulation of penile erection (GO:0060405)2.78851460
94opioid receptor signaling pathway (GO:0038003)2.77803323
95regulation of vesicle fusion (GO:0031338)2.77723377
96positive regulation of organic acid transport (GO:0032892)2.76418313
97regulation of amino acid transport (GO:0051955)2.75603310
98membrane hyperpolarization (GO:0060081)2.73701116
99regulation of neurotransmitter secretion (GO:0046928)2.73429968
100regulation of postsynaptic membrane potential (GO:0060078)2.73113676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.47070881
2GBX2_23144817_ChIP-Seq_PC3_Human4.11238178
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04159569
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96713491
5TAF15_26573619_Chip-Seq_HEK293_Human2.91909592
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91331046
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.70416062
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65690731
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.63880778
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.61994796
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58244884
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36689081
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36086672
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36086672
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30021581
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.28357752
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26144686
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25006408
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23751255
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18518058
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11232849
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10329055
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.02728143
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02499093
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01555597
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.00061071
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96780323
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.95421234
29P300_19829295_ChIP-Seq_ESCs_Human1.87900880
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87380459
31* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86959978
32SMAD4_21799915_ChIP-Seq_A2780_Human1.81821881
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81549711
34AR_21572438_ChIP-Seq_LNCaP_Human1.80079343
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.73431266
36DROSHA_22980978_ChIP-Seq_HELA_Human1.70484325
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.67555849
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66101266
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62668230
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61982612
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61470726
42VDR_22108803_ChIP-Seq_LS180_Human1.61292586
43RNF2_27304074_Chip-Seq_NSC_Mouse1.60135958
44FUS_26573619_Chip-Seq_HEK293_Human1.57085193
45IGF1R_20145208_ChIP-Seq_DFB_Human1.55142212
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.52965934
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.49028265
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45460867
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45146549
50ER_23166858_ChIP-Seq_MCF-7_Human1.44516658
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40959565
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.39746425
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39483115
54AR_25329375_ChIP-Seq_VCAP_Human1.39166710
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38814164
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36168364
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34923259
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32999621
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.32138865
60TP53_18474530_ChIP-ChIP_U2OS_Human1.31046003
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27472645
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.27440939
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26869836
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21547480
65* JUN_21703547_ChIP-Seq_K562_Human1.19220512
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16443682
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.15764797
68STAT3_23295773_ChIP-Seq_U87_Human1.14348677
69* RING1B_27294783_Chip-Seq_ESCs_Mouse1.13127628
70RUNX2_22187159_ChIP-Seq_PCA_Human1.12828535
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12036524
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11287955
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10485442
74TCF4_23295773_ChIP-Seq_U87_Human1.08810332
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.08628960
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06341770
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.05508328
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05459292
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05391757
80KDM2B_26808549_Chip-Seq_REH_Human1.05300314
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04250171
82ZNF274_21170338_ChIP-Seq_K562_Hela1.03935817
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03027703
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03027703
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.02591627
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02532761
87P53_22387025_ChIP-Seq_ESCs_Mouse1.01765479
88AHR_22903824_ChIP-Seq_MCF-7_Human0.99935818
89CMYC_18555785_Chip-Seq_ESCs_Mouse0.99679869
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98878399
91NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98487596
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97848818
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97792792
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96888141
95AR_19668381_ChIP-Seq_PC3_Human0.96063163
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95966780
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95025328
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94768711
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92855746
100SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92396930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.24572208
2MP0005645_abnormal_hypothalamus_physiol4.29152722
3MP0004859_abnormal_synaptic_plasticity4.25098888
4MP0006276_abnormal_autonomic_nervous3.58709355
5MP0003635_abnormal_synaptic_transmissio3.44843289
6MP0001529_abnormal_vocalization3.19208044
7MP0009745_abnormal_behavioral_response3.12335084
8MP0002064_seizures2.98184205
9MP0001968_abnormal_touch/_nociception2.92525579
10MP0005423_abnormal_somatic_nervous2.87478966
11MP0004270_analgesia2.83218062
12MP0002736_abnormal_nociception_after2.80864030
13MP0002063_abnormal_learning/memory/cond2.73818051
14MP0002572_abnormal_emotion/affect_behav2.70935233
15MP0009046_muscle_twitch2.67225301
16MP0003122_maternal_imprinting2.57321436
17MP0001440_abnormal_grooming_behavior2.37388782
18MP0002734_abnormal_mechanical_nocicepti2.31689791
19MP0002272_abnormal_nervous_system2.29685501
20MP0005646_abnormal_pituitary_gland2.29310765
21MP0002735_abnormal_chemical_nociception2.23283338
22MP0001486_abnormal_startle_reflex2.14912102
23MP0001501_abnormal_sleep_pattern2.11334302
24MP0000778_abnormal_nervous_system2.00959477
25MP0002067_abnormal_sensory_capabilities1.91581206
26MP0003787_abnormal_imprinting1.89329339
27MP0002557_abnormal_social/conspecific_i1.70071205
28MP0004142_abnormal_muscle_tone1.70008283
29MP0001188_hyperpigmentation1.69863472
30MP0001970_abnormal_pain_threshold1.69619412
31MP0004924_abnormal_behavior1.66477751
32MP0005386_behavior/neurological_phenoty1.66477751
33MP0002184_abnormal_innervation1.62502864
34MP0004858_abnormal_nervous_system1.59681386
35MP0009780_abnormal_chondrocyte_physiolo1.59408738
36MP0002733_abnormal_thermal_nociception1.56176235
37MP0002876_abnormal_thyroid_physiology1.48996664
38MP0001502_abnormal_circadian_rhythm1.46438807
39MP0001984_abnormal_olfaction1.36301758
40MP0001905_abnormal_dopamine_level1.34954635
41MP0000751_myopathy1.34330541
42MP0004811_abnormal_neuron_physiology1.32751366
43MP0000631_abnormal_neuroendocrine_gland1.32306586
44MP0002163_abnormal_gland_morphology1.28689324
45MP0002882_abnormal_neuron_morphology1.24575244
46MP0002066_abnormal_motor_capabilities/c1.24327600
47MP0000955_abnormal_spinal_cord1.24258472
48MP0005171_absent_coat_pigmentation1.23123465
49MP0005379_endocrine/exocrine_gland_phen1.20968049
50MP0003690_abnormal_glial_cell1.19699772
51MP0008569_lethality_at_weaning1.17067287
52MP0003121_genomic_imprinting1.16510315
53MP0005551_abnormal_eye_electrophysiolog1.10438028
54MP0002837_dystrophic_cardiac_calcinosis1.07433736
55MP0003329_amyloid_beta_deposits1.05806069
56MP0001177_atelectasis1.03820381
57MP0003633_abnormal_nervous_system1.01221938
58MP0002152_abnormal_brain_morphology0.98301054
59MP0003879_abnormal_hair_cell0.98299637
60MP0004885_abnormal_endolymph0.97462178
61MP0000566_synostosis0.96445208
62MP0002069_abnormal_eating/drinking_beha0.95899618
63MP0002822_catalepsy0.93186354
64MP0003631_nervous_system_phenotype0.89826158
65MP0001986_abnormal_taste_sensitivity0.88389261
66MP0004742_abnormal_vestibular_system0.84883486
67MP0009379_abnormal_foot_pigmentation0.84835876
68MP0005623_abnormal_meninges_morphology0.84570323
69MP0008872_abnormal_physiological_respon0.83383347
70MP0010386_abnormal_urinary_bladder0.82181728
71MP0003634_abnormal_glial_cell0.82099197
72MP0003123_paternal_imprinting0.82009824
73MP0001963_abnormal_hearing_physiology0.80114834
74MP0005535_abnormal_body_temperature0.77473778
75MP0000013_abnormal_adipose_tissue0.77153990
76MP0004484_altered_response_of0.76748414
77MP0002752_abnormal_somatic_nervous0.76215808
78MP0002638_abnormal_pupillary_reflex0.74965449
79MP0002229_neurodegeneration0.74193542
80MP0002332_abnormal_exercise_endurance0.73292252
81MP0002277_abnormal_respiratory_mucosa0.72442101
82MP0000026_abnormal_inner_ear0.70631196
83MP0003646_muscle_fatigue0.69176312
84MP0001943_abnormal_respiration0.67533320
85MP0005409_darkened_coat_color0.67368904
86MP0003632_abnormal_nervous_system0.64757720
87MP0002909_abnormal_adrenal_gland0.64672114
88MP0004043_abnormal_pH_regulation0.61607176
89MP0006292_abnormal_olfactory_placode0.60537407
90MP0000920_abnormal_myelination0.58766837
91MP0003938_abnormal_ear_development0.57547119
92MP0005253_abnormal_eye_physiology0.56817122
93MP0000049_abnormal_middle_ear0.55733518
94MP0000681_abnormal_thyroid_gland0.54784788
95MP0008874_decreased_physiological_sensi0.54614533
96MP0002090_abnormal_vision0.52224426
97MP0005394_taste/olfaction_phenotype0.51893777
98MP0005499_abnormal_olfactory_system0.51893777
99MP0003385_abnormal_body_wall0.51664268
100MP0002177_abnormal_outer_ear0.48314630

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.88336139
2Atonic seizures (HP:0010819)4.55258620
3Myokymia (HP:0002411)4.50812353
4Focal seizures (HP:0007359)4.40561661
5Febrile seizures (HP:0002373)4.34223403
6Abnormal hair whorl (HP:0010721)4.11014023
7Polyphagia (HP:0002591)3.87375685
8Epileptic encephalopathy (HP:0200134)3.66063545
9Generalized tonic-clonic seizures (HP:0002069)3.62065096
10Abnormality of the labia minora (HP:0012880)3.44078774
11Gait imbalance (HP:0002141)3.39612879
12Absence seizures (HP:0002121)3.37123250
13Dialeptic seizures (HP:0011146)3.35532921
14Abnormal eating behavior (HP:0100738)3.31410651
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.18366491
16Ankle clonus (HP:0011448)3.14419723
17Impaired vibration sensation in the lower limbs (HP:0002166)3.12789989
18Limb dystonia (HP:0002451)3.08333911
19Visual hallucinations (HP:0002367)3.02062629
20Progressive cerebellar ataxia (HP:0002073)2.89003242
21Congenital primary aphakia (HP:0007707)2.87172212
22Hyperventilation (HP:0002883)2.85271264
23Medial flaring of the eyebrow (HP:0010747)2.82991844
24Mutism (HP:0002300)2.79957631
25Oligomenorrhea (HP:0000876)2.74088772
26Poor suck (HP:0002033)2.73727103
27Narrow nasal bridge (HP:0000446)2.68065608
28Broad-based gait (HP:0002136)2.67578718
29Specific learning disability (HP:0001328)2.67447179
30Nephrogenic diabetes insipidus (HP:0009806)2.63217513
31Vaginal atresia (HP:0000148)2.59991573
32Retinal dysplasia (HP:0007973)2.58590622
33Fetal akinesia sequence (HP:0001989)2.57824581
34Esotropia (HP:0000565)2.53665458
35Pheochromocytoma (HP:0002666)2.52631388
36Failure to thrive in infancy (HP:0001531)2.50479871
37Genital tract atresia (HP:0001827)2.49546023
38Anxiety (HP:0000739)2.47591488
39Sleep apnea (HP:0010535)2.43797997
40Neurofibrillary tangles (HP:0002185)2.37908487
41Abnormality of the corticospinal tract (HP:0002492)2.37828596
42Acute necrotizing encephalopathy (HP:0006965)2.37294952
43Akinesia (HP:0002304)2.35302281
44Neuroendocrine neoplasm (HP:0100634)2.35053517
45Supranuclear gaze palsy (HP:0000605)2.34577550
46Alacrima (HP:0000522)2.22056099
47Excessive salivation (HP:0003781)2.20120704
48Drooling (HP:0002307)2.20120704
49Hypothermia (HP:0002045)2.19202148
50Spastic gait (HP:0002064)2.19107581
51Decreased lacrimation (HP:0000633)2.15900943
52Synostosis involving the elbow (HP:0003938)2.15235920
53Humeroradial synostosis (HP:0003041)2.15235920
54Epileptiform EEG discharges (HP:0011182)2.15032069
55Depression (HP:0000716)2.13096783
56Abnormal mitochondria in muscle tissue (HP:0008316)2.10532816
57Incomplete penetrance (HP:0003829)2.09675759
58Neuronal loss in central nervous system (HP:0002529)2.09662761
59Aplasia/Hypoplasia of the lens (HP:0008063)2.08904358
60Insidious onset (HP:0003587)2.08303796
61Termporal pattern (HP:0011008)2.08303796
62Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07625808
63Lower limb muscle weakness (HP:0007340)2.06202761
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05391659
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.05391659
66Progressive macrocephaly (HP:0004481)2.04336080
67EEG with generalized epileptiform discharges (HP:0011198)2.03531081
68Dysdiadochokinesis (HP:0002075)2.03501643
69Septo-optic dysplasia (HP:0100842)2.03389296
70Poor coordination (HP:0002370)2.01397269
71Hepatocellular necrosis (HP:0001404)2.01392681
72Absent speech (HP:0001344)2.01324969
73Truncal ataxia (HP:0002078)2.01160820
74Mitochondrial inheritance (HP:0001427)1.99808772
75Lissencephaly (HP:0001339)1.99631306
76Progressive inability to walk (HP:0002505)1.99260712
77Hypoventilation (HP:0002791)1.97707367
78Dysmetria (HP:0001310)1.97354504
79Type II lissencephaly (HP:0007260)1.96936444
80Agitation (HP:0000713)1.96398512
81Abnormal ciliary motility (HP:0012262)1.93581157
82Hypsarrhythmia (HP:0002521)1.92756265
83Abnormality of binocular vision (HP:0011514)1.91492860
84Diplopia (HP:0000651)1.91492860
85Urinary bladder sphincter dysfunction (HP:0002839)1.91459263
86Abnormality of salivation (HP:0100755)1.91442015
87Hemiparesis (HP:0001269)1.90074347
88Growth hormone deficiency (HP:0000824)1.88814436
89Cerebral inclusion bodies (HP:0100314)1.87248607
90Menstrual irregularities (HP:0000858)1.84847465
91Diminished movement (HP:0002374)1.84693906
92Scanning speech (HP:0002168)1.84198702
93Psychosis (HP:0000709)1.84053183
94Aplasia involving bones of the extremities (HP:0009825)1.81542349
95Aplasia involving bones of the upper limbs (HP:0009823)1.81542349
96Aplasia of the phalanges of the hand (HP:0009802)1.81542349
97Dynein arm defect of respiratory motile cilia (HP:0012255)1.80471238
98Absent/shortened dynein arms (HP:0200106)1.80471238
99Bradykinesia (HP:0002067)1.79133358
100Torticollis (HP:0000473)1.78324593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.21321119
2CASK4.05218194
3MAP3K123.80611876
4MARK13.66943155
5EPHA42.85496439
6MAP2K72.69890641
7MAP3K42.64469010
8NTRK22.27081616
9MINK12.17420135
10TNIK2.06829046
11BCR1.98685308
12MAPK131.95278317
13GRK71.87444412
14PLK21.83547243
15CDK191.61720370
16ADRBK21.56533734
17MAP2K41.55348110
18OXSR11.51103991
19PAK61.46547985
20PNCK1.39560604
21CAMK2A1.34608886
22SIK21.32130480
23PRKCG1.31716365
24GRK51.30597637
25CDK51.30235731
26TSSK61.25277826
27DAPK21.24390765
28UHMK11.23738877
29PHKG21.21926534
30PHKG11.21926534
31PKN11.18894898
32NME11.18412823
33DAPK11.17760561
34FES1.13732191
35NTRK11.12123364
36ARAF1.11552692
37CAMK2B1.09471906
38SGK2231.02511433
39SGK4941.02511433
40SIK30.98462383
41PIK3CG0.96689782
42MAP3K90.94481714
43PRKCE0.92638243
44CAMK2G0.90707716
45STK390.90625077
46CSNK1G20.89410780
47AKT30.88029589
48PAK30.87845100
49LIMK10.85542118
50CAMK2D0.83989909
51SGK20.81805478
52LATS20.81009203
53KSR10.80208425
54EPHB20.80207013
55FER0.80039381
56MUSK0.75876588
57CAMK10.75684465
58PRPF4B0.75428635
59RPS6KA20.74025755
60MYLK0.73130308
61CSNK1G30.73010884
62TAOK30.72904948
63CDK180.72679001
64CDK140.72593741
65DYRK20.70421732
66DYRK1A0.69873356
67CDK150.68690803
68SGK10.67327463
69STK110.65358679
70ADRBK10.63457988
71TNK20.60557589
72CDK11A0.57661350
73FGR0.54579031
74ROCK20.53708669
75NEK60.53503828
76STK380.50358627
77CSNK1A1L0.49891371
78PRKACA0.49874402
79PRKG10.49018344
80STK160.48761192
81MAP3K20.47694222
82CAMKK10.47122552
83ERBB30.46940211
84YES10.46249250
85STK240.42315953
86WNK30.41803827
87LMTK20.40692202
88PRKCA0.40616104
89FYN0.40426223
90EIF2AK20.39608574
91PRKCB0.39438760
92PRKCH0.39214230
93RPS6KA30.38211411
94KSR20.37839984
95CAMK40.36619029
96PRKCQ0.35860615
97RPS6KC10.35460280
98RPS6KL10.35460280
99DAPK30.35245528
100ROCK10.34894856

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.52965165
2Synaptic vesicle cycle_Homo sapiens_hsa047213.36136920
3Collecting duct acid secretion_Homo sapiens_hsa049662.95412618
4GABAergic synapse_Homo sapiens_hsa047272.90020341
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81231439
6Oxidative phosphorylation_Homo sapiens_hsa001902.66141388
7Morphine addiction_Homo sapiens_hsa050322.64909389
8Olfactory transduction_Homo sapiens_hsa047402.52475499
9Circadian entrainment_Homo sapiens_hsa047132.39244372
10Glutamatergic synapse_Homo sapiens_hsa047242.38017416
11Vibrio cholerae infection_Homo sapiens_hsa051102.10628825
12Amphetamine addiction_Homo sapiens_hsa050312.07788478
13Serotonergic synapse_Homo sapiens_hsa047261.99379576
14Taste transduction_Homo sapiens_hsa047421.98405053
15Long-term potentiation_Homo sapiens_hsa047201.98005187
16Salivary secretion_Homo sapiens_hsa049701.89807481
17Alzheimers disease_Homo sapiens_hsa050101.80348993
18Parkinsons disease_Homo sapiens_hsa050121.78164802
19Long-term depression_Homo sapiens_hsa047301.72708218
20Cocaine addiction_Homo sapiens_hsa050301.70541760
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68814027
22Dopaminergic synapse_Homo sapiens_hsa047281.66139695
23* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64669502
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61852071
25Insulin secretion_Homo sapiens_hsa049111.58816240
26Cholinergic synapse_Homo sapiens_hsa047251.58616245
27Renin secretion_Homo sapiens_hsa049241.57597748
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50731377
29Calcium signaling pathway_Homo sapiens_hsa040201.47386659
30Gastric acid secretion_Homo sapiens_hsa049711.45034041
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.39454647
32Cardiac muscle contraction_Homo sapiens_hsa042601.39089792
33Axon guidance_Homo sapiens_hsa043601.38040503
34Huntingtons disease_Homo sapiens_hsa050161.29600686
35Phototransduction_Homo sapiens_hsa047441.26961775
36Rheumatoid arthritis_Homo sapiens_hsa053231.24836606
37Type I diabetes mellitus_Homo sapiens_hsa049401.21880651
38Oxytocin signaling pathway_Homo sapiens_hsa049211.21376365
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20468022
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16947866
41Phagosome_Homo sapiens_hsa041451.12442592
42Gap junction_Homo sapiens_hsa045401.09640523
43Melanogenesis_Homo sapiens_hsa049161.08911312
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07519636
45cAMP signaling pathway_Homo sapiens_hsa040241.02212212
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01985749
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96084666
48ErbB signaling pathway_Homo sapiens_hsa040120.92647492
49GnRH signaling pathway_Homo sapiens_hsa049120.91790606
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84603257
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84295550
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80768365
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79504081
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78443844
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.78259824
56Estrogen signaling pathway_Homo sapiens_hsa049150.71403603
57Steroid biosynthesis_Homo sapiens_hsa001000.68735806
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65451996
59Thyroid hormone synthesis_Homo sapiens_hsa049180.63802800
60Dilated cardiomyopathy_Homo sapiens_hsa054140.63473650
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60050185
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56353597
63African trypanosomiasis_Homo sapiens_hsa051430.55606956
64Butanoate metabolism_Homo sapiens_hsa006500.53522648
65MAPK signaling pathway_Homo sapiens_hsa040100.52843571
66Pancreatic secretion_Homo sapiens_hsa049720.50741691
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50544001
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49602408
69Ras signaling pathway_Homo sapiens_hsa040140.49362921
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48148570
71Fatty acid elongation_Homo sapiens_hsa000620.46358071
72Type II diabetes mellitus_Homo sapiens_hsa049300.45661173
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.43752929
74Prion diseases_Homo sapiens_hsa050200.43036543
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41432639
76Sphingolipid metabolism_Homo sapiens_hsa006000.40329209
77Alcoholism_Homo sapiens_hsa050340.39791288
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39486206
79Wnt signaling pathway_Homo sapiens_hsa043100.35828695
80Ovarian steroidogenesis_Homo sapiens_hsa049130.35034615
81Choline metabolism in cancer_Homo sapiens_hsa052310.34864126
82Glioma_Homo sapiens_hsa052140.34217857
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33519618
84Dorso-ventral axis formation_Homo sapiens_hsa043200.32999169
85Glucagon signaling pathway_Homo sapiens_hsa049220.32915659
86Hedgehog signaling pathway_Homo sapiens_hsa043400.32704586
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.32456656
88Ether lipid metabolism_Homo sapiens_hsa005650.31171766
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29879918
90Renal cell carcinoma_Homo sapiens_hsa052110.29696151
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28541227
92Sulfur metabolism_Homo sapiens_hsa009200.27782125
93Protein export_Homo sapiens_hsa030600.26939840
94Inositol phosphate metabolism_Homo sapiens_hsa005620.26331565
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25246790
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24286775
97Rap1 signaling pathway_Homo sapiens_hsa040150.20185015
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.17992292
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17019455
100Chemokine signaling pathway_Homo sapiens_hsa040620.16352924

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