RWDD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)6.08957244
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.06041361
3respiratory electron transport chain (GO:0022904)5.59559614
4electron transport chain (GO:0022900)5.47684013
5maturation of SSU-rRNA (GO:0030490)5.34464964
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.24830742
7mitochondrial respiratory chain complex I assembly (GO:0032981)5.24830742
8NADH dehydrogenase complex assembly (GO:0010257)5.24830742
9protein complex biogenesis (GO:0070271)5.15509884
10DNA deamination (GO:0045006)4.95588594
11mitochondrial respiratory chain complex assembly (GO:0033108)4.94328423
12formation of translation preinitiation complex (GO:0001731)4.87085344
13protein neddylation (GO:0045116)4.77644792
14proteasome assembly (GO:0043248)4.64421939
15viral transcription (GO:0019083)4.63461938
16ribosomal small subunit assembly (GO:0000028)4.61021825
17translational termination (GO:0006415)4.60668536
18ribosomal large subunit biogenesis (GO:0042273)4.56395069
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.47496591
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.34829964
21ribosome assembly (GO:0042255)4.30030755
22positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.29947586
23translational initiation (GO:0006413)4.29884328
24ribosomal small subunit biogenesis (GO:0042274)4.29651268
25purine nucleobase biosynthetic process (GO:0009113)4.28691795
26cotranslational protein targeting to membrane (GO:0006613)4.24063282
27protein targeting to ER (GO:0045047)4.23844615
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.20848019
29translational elongation (GO:0006414)4.19466407
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.17782514
31ribonucleoprotein complex biogenesis (GO:0022613)4.16205009
32nucleobase biosynthetic process (GO:0046112)4.15857934
33respiratory chain complex IV assembly (GO:0008535)4.08794906
34transcription elongation from RNA polymerase III promoter (GO:0006385)4.07617289
35termination of RNA polymerase III transcription (GO:0006386)4.07617289
36negative regulation of ligase activity (GO:0051352)4.05298399
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.05298399
38ribosome biogenesis (GO:0042254)4.04963881
39establishment of protein localization to endoplasmic reticulum (GO:0072599)4.03420949
40protein localization to endoplasmic reticulum (GO:0070972)4.02880358
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.99967867
42protein-cofactor linkage (GO:0018065)3.98815866
43translation (GO:0006412)3.97200395
44regulation of cellular amino acid metabolic process (GO:0006521)3.85235342
45spliceosomal snRNP assembly (GO:0000387)3.84646148
46water-soluble vitamin biosynthetic process (GO:0042364)3.82654149
47positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.82387992
48rRNA processing (GO:0006364)3.78479878
49DNA replication checkpoint (GO:0000076)3.73104128
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.72618690
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.71933728
52DNA strand elongation involved in DNA replication (GO:0006271)3.71746916
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.70688037
54cellular protein complex disassembly (GO:0043624)3.70327670
55ATP biosynthetic process (GO:0006754)3.68898474
56mitotic metaphase plate congression (GO:0007080)3.68668998
57viral life cycle (GO:0019058)3.68120355
58ATP synthesis coupled proton transport (GO:0015986)3.67215132
59energy coupled proton transport, down electrochemical gradient (GO:0015985)3.67215132
60cytochrome complex assembly (GO:0017004)3.66358888
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.65337927
627-methylguanosine mRNA capping (GO:0006370)3.64909138
63rRNA metabolic process (GO:0016072)3.64492034
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.63912779
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.63912779
66signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.63789386
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.63789386
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.63789386
69positive regulation of ligase activity (GO:0051351)3.63637130
70hydrogen ion transmembrane transport (GO:1902600)3.63229248
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62062289
72rRNA modification (GO:0000154)3.61072434
73signal transduction involved in DNA damage checkpoint (GO:0072422)3.60914955
74signal transduction involved in DNA integrity checkpoint (GO:0072401)3.60914955
75RNA capping (GO:0036260)3.56037556
767-methylguanosine RNA capping (GO:0009452)3.56037556
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.55894534
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.55894534
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.55766675
80purine nucleoside triphosphate biosynthetic process (GO:0009145)3.55261584
81regulation of mitochondrial translation (GO:0070129)3.54666994
82signal transduction involved in cell cycle checkpoint (GO:0072395)3.54291568
83establishment of protein localization to mitochondrial membrane (GO:0090151)3.51965116
84purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.51098613
85DNA strand elongation (GO:0022616)3.50628353
86cullin deneddylation (GO:0010388)3.46161594
87DNA replication initiation (GO:0006270)3.45675312
88antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.45244058
89cellular component biogenesis (GO:0044085)3.45187718
90telomere maintenance via semi-conservative replication (GO:0032201)3.43370122
91pseudouridine synthesis (GO:0001522)3.42992793
92mitochondrial transport (GO:0006839)3.41450839
93L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.39764943
94intracellular protein transmembrane import (GO:0044743)3.39309383
95protein deneddylation (GO:0000338)3.37252433
96regulation of ubiquitin-protein transferase activity (GO:0051438)3.35965271
97nucleobase-containing small molecule interconversion (GO:0015949)3.35921905
98spliceosomal complex assembly (GO:0000245)3.32613194
99oxidative phosphorylation (GO:0006119)3.32478873
100transcription from RNA polymerase I promoter (GO:0006360)3.29668876
101transcription elongation from RNA polymerase I promoter (GO:0006362)3.28522377
102folic acid-containing compound biosynthetic process (GO:0009396)3.27251390
103transcription-coupled nucleotide-excision repair (GO:0006283)3.24913273
104cell cycle G1/S phase transition (GO:0044843)3.24816550
105G1/S transition of mitotic cell cycle (GO:0000082)3.24816550
106establishment of protein localization to mitochondrion (GO:0072655)3.24489837
107guanosine-containing compound biosynthetic process (GO:1901070)3.24355084
108termination of RNA polymerase I transcription (GO:0006363)3.24338865
109proton transport (GO:0015992)3.23614210
110regulation of ligase activity (GO:0051340)3.22234479
111protein complex disassembly (GO:0043241)3.21632499
112inner mitochondrial membrane organization (GO:0007007)3.21346279
113protein targeting to mitochondrion (GO:0006626)3.19198533
114hydrogen transport (GO:0006818)3.17097998
115telomere maintenance via recombination (GO:0000722)3.15210085
116regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14925060
117macromolecular complex disassembly (GO:0032984)3.13993239
118ribonucleoside triphosphate biosynthetic process (GO:0009201)3.13122140
119positive regulation of cell cycle arrest (GO:0071158)3.08624659
120protein localization to mitochondrion (GO:0070585)3.07914569
121protein targeting to membrane (GO:0006612)3.04489766
122peptidyl-histidine modification (GO:0018202)3.02998022
123CENP-A containing nucleosome assembly (GO:0034080)3.01497946
124nucleoside triphosphate biosynthetic process (GO:0009142)2.98833866
125establishment of integrated proviral latency (GO:0075713)2.98427248
126viral mRNA export from host cell nucleus (GO:0046784)2.98067316
127IMP biosynthetic process (GO:0006188)2.97461467
128DNA replication-dependent nucleosome assembly (GO:0006335)2.96403220
129DNA replication-dependent nucleosome organization (GO:0034723)2.96403220
130chromatin remodeling at centromere (GO:0031055)2.95549044
131pteridine-containing compound biosynthetic process (GO:0042559)2.94834103
132GTP biosynthetic process (GO:0006183)2.94732388
133deoxyribonucleotide biosynthetic process (GO:0009263)2.93302134
134rRNA methylation (GO:0031167)2.89769163
135purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.86837646
136purine nucleoside monophosphate biosynthetic process (GO:0009127)2.86837646
137regulation of cellular respiration (GO:0043457)2.83262694
138tRNA processing (GO:0008033)2.82851484
139organelle disassembly (GO:1903008)2.81471712
140regulation of hexokinase activity (GO:1903299)2.75677805
141regulation of glucokinase activity (GO:0033131)2.75677805
142nuclear-transcribed mRNA catabolic process (GO:0000956)2.75406683
143mitochondrion morphogenesis (GO:0070584)2.75291973
144DNA damage response, detection of DNA damage (GO:0042769)2.74674846
145purine nucleotide salvage (GO:0032261)2.73910089
146intracellular protein transmembrane transport (GO:0065002)2.73044172
147histone exchange (GO:0043486)2.72179369
148protein transmembrane transport (GO:0071806)2.71587694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.30532126
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.63278921
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.21051507
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05126367
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.02139938
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.65305094
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.57292821
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.56518057
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.43715019
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12564425
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09139545
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99510861
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76096974
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74356997
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73324198
16* VDR_23849224_ChIP-Seq_CD4+_Human2.65731568
17XRN2_22483619_ChIP-Seq_HELA_Human2.55305581
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54166867
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52246811
20* DCP1A_22483619_ChIP-Seq_HELA_Human2.50091963
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45345446
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37699648
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.34613186
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.34553848
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33368969
26* GABP_19822575_ChIP-Seq_HepG2_Human2.22174805
27VDR_22108803_ChIP-Seq_LS180_Human2.22067663
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15177183
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12518700
30* FOXP3_21729870_ChIP-Seq_TREG_Human2.12282745
31TTF2_22483619_ChIP-Seq_HELA_Human2.07243478
32ELK1_19687146_ChIP-ChIP_HELA_Human2.03548304
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03375895
34* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96256410
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95624074
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94665803
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88058518
38* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85771074
39FUS_26573619_Chip-Seq_HEK293_Human1.82096164
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80924937
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.77713753
42* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77413484
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76219059
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.75908328
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70756397
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70274644
47EWS_26573619_Chip-Seq_HEK293_Human1.67512333
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67230774
49ZNF274_21170338_ChIP-Seq_K562_Hela1.63718869
50AR_21909140_ChIP-Seq_LNCAP_Human1.62659509
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62096500
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61896797
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60365029
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59857684
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54502326
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.53416315
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52116858
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.49853727
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.48140397
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46490754
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45066282
62KDM5A_27292631_Chip-Seq_BREAST_Human1.43021776
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40479668
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40274960
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35992076
66CIITA_25753668_ChIP-Seq_RAJI_Human1.35735950
67* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34892547
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33930058
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31033667
70TFEB_21752829_ChIP-Seq_HELA_Human1.23806699
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23351945
72* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21784317
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21766464
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21555885
75TP53_22573176_ChIP-Seq_HFKS_Human1.20481681
76* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19196327
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18662405
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18382550
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17348172
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.15835539
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14766233
82TAF15_26573619_Chip-Seq_HEK293_Human1.12597350
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11117342
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10123577
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09908650
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09886360
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09865405
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09165116
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07915338
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07831216
91* MYC_18940864_ChIP-ChIP_HL60_Human1.07462784
92* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07249872
93IGF1R_20145208_ChIP-Seq_DFB_Human1.05535018
94ZNF263_19887448_ChIP-Seq_K562_Human1.05343439
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04606580
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04077819
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01762720
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01691014
99P300_19829295_ChIP-Seq_ESCs_Human1.01501735
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00457011
101* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99595594
102HTT_18923047_ChIP-ChIP_STHdh_Human0.99522050
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99387673
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99259397
105CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98203075
106CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97533573
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97150005
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96842075
109SOX2_19829295_ChIP-Seq_ESCs_Human0.96726808
110NANOG_19829295_ChIP-Seq_ESCs_Human0.96726808
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96715739
112SPI1_23547873_ChIP-Seq_NB4_Human0.96211724
113* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94064020
114CBX2_27304074_Chip-Seq_ESCs_Mouse0.93305908
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92994094
116MYC_22102868_ChIP-Seq_BL_Human0.92559963
117TP63_19390658_ChIP-ChIP_HaCaT_Human0.91422069
118* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91150539
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.90684525
120EGR1_19374776_ChIP-ChIP_THP-1_Human0.89059113
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88714133
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87432883
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86082738
124FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85554723
125* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85465534
126IRF1_19129219_ChIP-ChIP_H3396_Human0.84881585
127RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84660267
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83549503
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83469058
130SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83122610
131TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82614550
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82426363
133NCOR_22424771_ChIP-Seq_293T_Human0.81821304
134GBX2_23144817_ChIP-Seq_PC3_Human0.81698659
135CRX_20693478_ChIP-Seq_RETINA_Mouse0.80411340
136AR_20517297_ChIP-Seq_VCAP_Human0.79545431
137POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79323066
138SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79063355
139CTCF_18555785_ChIP-Seq_MESCs_Mouse0.78999661
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.78060666
141FOXA1_25329375_ChIP-Seq_VCAP_Human0.77976999
142FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77976999
143ER_23166858_ChIP-Seq_MCF-7_Human0.77041465
144PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.76448486
145JUN_21703547_ChIP-Seq_K562_Human0.75733922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.54568270
2MP0004957_abnormal_blastocyst_morpholog4.92182302
3MP0003111_abnormal_nucleus_morphology3.88391125
4MP0003077_abnormal_cell_cycle3.65265267
5MP0010094_abnormal_chromosome_stability3.58427272
6MP0008932_abnormal_embryonic_tissue3.05819152
7MP0008058_abnormal_DNA_repair2.72129860
8MP0003123_paternal_imprinting2.62786236
9MP0003718_maternal_effect2.62742611
10MP0008057_abnormal_DNA_replication2.37916724
11MP0001730_embryonic_growth_arrest2.32216345
12MP0008007_abnormal_cellular_replicative2.28739496
13MP0009046_muscle_twitch2.24488186
14MP0006072_abnormal_retinal_apoptosis2.20398974
15MP0000750_abnormal_muscle_regeneration2.15070560
16MP0006036_abnormal_mitochondrial_physio2.11190147
17MP0009333_abnormal_splenocyte_physiolog2.10409128
18MP0005084_abnormal_gallbladder_morpholo2.06292119
19MP0002102_abnormal_ear_morphology2.02349362
20MP0000350_abnormal_cell_proliferation2.01592597
21MP0003646_muscle_fatigue1.94542411
22MP0004142_abnormal_muscle_tone1.91450897
23MP0003011_delayed_dark_adaptation1.91059480
24MP0005646_abnormal_pituitary_gland1.87740236
25MP0003186_abnormal_redox_activity1.86866145
26MP0003786_premature_aging1.86169701
27MP0001984_abnormal_olfaction1.77215537
28MP0002736_abnormal_nociception_after1.76022749
29MP0006035_abnormal_mitochondrial_morpho1.69131013
30MP0001697_abnormal_embryo_size1.66215205
31MP0003221_abnormal_cardiomyocyte_apopto1.62876976
32MP0000358_abnormal_cell_content/1.61998302
33MP0002080_prenatal_lethality1.59923610
34MP0001905_abnormal_dopamine_level1.59634488
35MP0003806_abnormal_nucleotide_metabolis1.58392697
36MP0001968_abnormal_touch/_nociception1.53022099
37MP0003880_abnormal_central_pattern1.50434141
38MP0002272_abnormal_nervous_system1.49742361
39MP0002638_abnormal_pupillary_reflex1.48903786
40MP0005551_abnormal_eye_electrophysiolog1.48797320
41MP0003567_abnormal_fetal_cardiomyocyte1.46509409
42MP0000313_abnormal_cell_death1.45691785
43MP0009379_abnormal_foot_pigmentation1.45570418
44MP0005380_embryogenesis_phenotype1.45143539
45MP0001672_abnormal_embryogenesis/_devel1.45143539
46MP0004084_abnormal_cardiac_muscle1.44152645
47MP0009745_abnormal_behavioral_response1.40241384
48MP0001764_abnormal_homeostasis1.39267031
49MP0000490_abnormal_crypts_of1.38116447
50MP0008872_abnormal_physiological_respon1.37865914
51MP0005670_abnormal_white_adipose1.37705944
52MP0005253_abnormal_eye_physiology1.36032982
53MP0005332_abnormal_amino_acid1.35083684
54MP0002396_abnormal_hematopoietic_system1.34978561
55MP0003195_calcinosis1.32042637
56MP0003136_yellow_coat_color1.31594833
57MP0009697_abnormal_copulation1.30669643
58MP0003984_embryonic_growth_retardation1.30018564
59MP0004147_increased_porphyrin_level1.29970411
60MP0008260_abnormal_autophagy1.29447239
61MP0003315_abnormal_perineum_morphology1.28057298
62MP0010307_abnormal_tumor_latency1.27631373
63MP0005379_endocrine/exocrine_gland_phen1.26729292
64MP0010386_abnormal_urinary_bladder1.26309275
65MP0002088_abnormal_embryonic_growth/wei1.25444888
66MP0010352_gastrointestinal_tract_polyps1.22968095
67MP0006276_abnormal_autonomic_nervous1.21679972
68MP0008789_abnormal_olfactory_epithelium1.21318411
69MP0001485_abnormal_pinna_reflex1.20482953
70MP0004145_abnormal_muscle_electrophysio1.20148185
71MP0002876_abnormal_thyroid_physiology1.19386812
72MP0002019_abnormal_tumor_incidence1.18525275
73MP0002234_abnormal_pharynx_morphology1.18073564
74MP0005187_abnormal_penis_morphology1.17999538
75MP0003787_abnormal_imprinting1.15298531
76MP0002085_abnormal_embryonic_tissue1.14387149
77MP0001529_abnormal_vocalization1.13229775
78MP0002163_abnormal_gland_morphology1.12331255
79MP0001188_hyperpigmentation1.12281261
80MP0005645_abnormal_hypothalamus_physiol1.09686711
81MP0008875_abnormal_xenobiotic_pharmacok1.09684914
82MP0001542_abnormal_bone_strength1.06229457
83MP0000858_altered_metastatic_potential1.05378188
84MP0003121_genomic_imprinting1.02822296
85MP0003950_abnormal_plasma_membrane1.01710108
86MP0000049_abnormal_middle_ear1.01556925
87MP0008995_early_reproductive_senescence1.01270410
88MP0008877_abnormal_DNA_methylation1.01250561
89MP0000631_abnormal_neuroendocrine_gland0.98402787
90MP0002084_abnormal_developmental_patter0.98083667
91MP0001853_heart_inflammation0.97290002
92MP0004808_abnormal_hematopoietic_stem0.95008404
93MP0002277_abnormal_respiratory_mucosa0.94909562
94MP0005330_cardiomyopathy0.94198434
95MP0000747_muscle_weakness0.92706091
96MP0002269_muscular_atrophy0.92521917
97MP0000703_abnormal_thymus_morphology0.92469976
98MP0002064_seizures0.92353449
99MP0002106_abnormal_muscle_physiology0.91614465
100MP0002086_abnormal_extraembryonic_tissu0.91448442
101MP0000749_muscle_degeneration0.91001899
102MP0001727_abnormal_embryo_implantation0.89526693
103MP0009250_abnormal_appendicular_skeleto0.89269160
104MP0004036_abnormal_muscle_relaxation0.89257496
105MP0000013_abnormal_adipose_tissue0.88631954
106MP0004742_abnormal_vestibular_system0.87918825
107MP0005384_cellular_phenotype0.87635940
108MP0002722_abnormal_immune_system0.87309614
109MP0005389_reproductive_system_phenotype0.85779969
110MP0002398_abnormal_bone_marrow0.85162761
111MP0002210_abnormal_sex_determination0.83146411
112MP0002693_abnormal_pancreas_physiology0.82224343
113MP0003137_abnormal_impulse_conducting0.82003294
114MP0004885_abnormal_endolymph0.81306929
115MP0005671_abnormal_response_to0.81233589
116MP0006292_abnormal_olfactory_placode0.80346434
117MP0002090_abnormal_vision0.79792395
118MP0004197_abnormal_fetal_growth/weight/0.79748494
119MP0004043_abnormal_pH_regulation0.79437956
120MP0002160_abnormal_reproductive_system0.79253564
121MP0010030_abnormal_orbit_morphology0.78822049
122MP0002067_abnormal_sensory_capabilities0.78154447
123MP0001145_abnormal_male_reproductive0.76645997
124MP0002132_abnormal_respiratory_system0.76420659
125MP0000689_abnormal_spleen_morphology0.76407340
126MP0000372_irregular_coat_pigmentation0.76127977
127MP0003763_abnormal_thymus_physiology0.75445834
128MP0002095_abnormal_skin_pigmentation0.74670460
129MP0002429_abnormal_blood_cell0.74527319
130MP0001440_abnormal_grooming_behavior0.74381450
131MP0009840_abnormal_foam_cell0.74098508
132MP0005195_abnormal_posterior_eye0.73430437
133MP0005621_abnormal_cell_physiology0.73058711
134MP0004924_abnormal_behavior0.71905722
135MP0005386_behavior/neurological_phenoty0.71905722
136MP0001293_anophthalmia0.71052787
137MP0009785_altered_susceptibility_to0.70987962
138MP0006054_spinal_hemorrhage0.70476720
139MP0005636_abnormal_mineral_homeostasis0.70401300
140MP0004215_abnormal_myocardial_fiber0.69652360
141MP0001944_abnormal_pancreas_morphology0.68573745
142MP0002837_dystrophic_cardiac_calcinosis0.68143456
143MP0003119_abnormal_digestive_system0.67692831
144MP0008775_abnormal_heart_ventricle0.67655062
145MP0000759_abnormal_skeletal_muscle0.67418811
146MP0002572_abnormal_emotion/affect_behav0.65836464
147MP0002735_abnormal_chemical_nociception0.64737422
148MP0001919_abnormal_reproductive_system0.64230651
149MP0005620_abnormal_muscle_contractility0.63696450
150MP0000716_abnormal_immune_system0.62843057
151MP0005410_abnormal_fertilization0.62571401
152MP0005395_other_phenotype0.62055428
153MP0002938_white_spotting0.61040068
154MP0005408_hypopigmentation0.60060854
155MP0000428_abnormal_craniofacial_morphol0.59415028
156MP0002877_abnormal_melanocyte_morpholog0.59215296
157MP0004233_abnormal_muscle_weight0.58948026
158MP0005266_abnormal_metabolism0.57587738
159MP0005369_muscle_phenotype0.57338531
160MP0003436_decreased_susceptibility_to0.57303937
161MP0005397_hematopoietic_system_phenotyp0.56967747
162MP0001545_abnormal_hematopoietic_system0.56967747
163MP0000653_abnormal_sex_gland0.55964511

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.85597566
2Abnormal number of erythroid precursors (HP:0012131)4.47352881
3Birth length less than 3rd percentile (HP:0003561)4.33362176
4Acute necrotizing encephalopathy (HP:0006965)4.27032791
5Reticulocytopenia (HP:0001896)4.16253743
6Abnormal mitochondria in muscle tissue (HP:0008316)3.99378537
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.96940150
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.96940150
9Renal Fanconi syndrome (HP:0001994)3.93918325
10Mitochondrial inheritance (HP:0001427)3.71249752
11Multiple enchondromatosis (HP:0005701)3.65890532
12Cerebral hypomyelination (HP:0006808)3.64231868
13Carpal bone hypoplasia (HP:0001498)3.58286489
14Rough bone trabeculation (HP:0100670)3.57099578
15Abnormality of the anterior horn cell (HP:0006802)3.54053829
16Degeneration of anterior horn cells (HP:0002398)3.54053829
17Hepatocellular necrosis (HP:0001404)3.52642239
18Breast hypoplasia (HP:0003187)3.50558804
19Macrocytic anemia (HP:0001972)3.46545724
20Increased CSF lactate (HP:0002490)3.43192218
21Hepatic necrosis (HP:0002605)3.38389360
22Progressive macrocephaly (HP:0004481)3.29982226
23Acute encephalopathy (HP:0006846)3.25883535
24Oral leukoplakia (HP:0002745)3.24833882
25Pallor (HP:0000980)3.20530560
26Progressive muscle weakness (HP:0003323)3.12199913
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.08841388
28Abnormality of alanine metabolism (HP:0010916)3.08841388
29Hyperalaninemia (HP:0003348)3.08841388
30Increased serum lactate (HP:0002151)2.99070897
31Methylmalonic acidemia (HP:0002912)2.97142782
32Microretrognathia (HP:0000308)2.93520271
33Abnormality of glycolysis (HP:0004366)2.89881512
34Increased serum pyruvate (HP:0003542)2.89881512
35Increased hepatocellular lipid droplets (HP:0006565)2.87428261
36Molar tooth sign on MRI (HP:0002419)2.83180151
37Abnormality of midbrain morphology (HP:0002418)2.83180151
383-Methylglutaconic aciduria (HP:0003535)2.82458600
39Leukodystrophy (HP:0002415)2.80829625
40Aplastic anemia (HP:0001915)2.75708098
41Trismus (HP:0000211)2.73305591
42Secondary amenorrhea (HP:0000869)2.72144590
43Exercise intolerance (HP:0003546)2.66071144
44Glossoptosis (HP:0000162)2.65054754
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63760817
46Optic disc pallor (HP:0000543)2.62284209
47Methylmalonic aciduria (HP:0012120)2.61210074
48Lactic acidosis (HP:0003128)2.60906273
49Abnormal trabecular bone morphology (HP:0100671)2.60154327
50Poor head control (HP:0002421)2.59397306
51Respiratory failure (HP:0002878)2.58976121
52Lipid accumulation in hepatocytes (HP:0006561)2.57779855
53Abnormality of renal resorption (HP:0011038)2.54983669
54Aplasia/Hypoplasia of the patella (HP:0006498)2.54208536
55Patellar aplasia (HP:0006443)2.54142868
56Pelvic girdle muscle weakness (HP:0003749)2.51491828
57Shoulder girdle muscle weakness (HP:0003547)2.50619139
58Atrophy/Degeneration involving motor neurons (HP:0007373)2.45509916
59Abnormality of the umbilical cord (HP:0010881)2.45367933
60Emotional lability (HP:0000712)2.44112565
61Premature ovarian failure (HP:0008209)2.43394754
62Lethargy (HP:0001254)2.41923570
63CNS demyelination (HP:0007305)2.41776780
64Glycosuria (HP:0003076)2.41580960
65Abnormality of urine glucose concentration (HP:0011016)2.41580960
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40968655
67Pancreatic fibrosis (HP:0100732)2.37047627
68Premature graying of hair (HP:0002216)2.34755189
69Generalized aminoaciduria (HP:0002909)2.34377488
70Pancreatic cysts (HP:0001737)2.33984619
71Postnatal microcephaly (HP:0005484)2.32770442
72Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.32757592
73Congenital, generalized hypertrichosis (HP:0004540)2.32043938
74Calcaneovalgus deformity (HP:0001848)2.31461132
75Irregular epiphyses (HP:0010582)2.27056873
76Colon cancer (HP:0003003)2.26719396
77Personality changes (HP:0000751)2.26677439
78Abnormality of serum amino acid levels (HP:0003112)2.26437626
79Deformed tarsal bones (HP:0008119)2.24323056
80Unsteady gait (HP:0002317)2.24300386
81Cleft eyelid (HP:0000625)2.23307372
82Large for gestational age (HP:0001520)2.22877769
83Abnormality of the musculature of the pelvis (HP:0001469)2.21870396
84Abnormality of the hip-girdle musculature (HP:0001445)2.21870396
85Cerebral edema (HP:0002181)2.21214398
8611 pairs of ribs (HP:0000878)2.21144941
87Respiratory difficulties (HP:0002880)2.17574239
88Nemaline bodies (HP:0003798)2.16711408
89Neoplasm of the pancreas (HP:0002894)2.16403835
90Abnormality of methionine metabolism (HP:0010901)2.15862116
91Delusions (HP:0000746)2.12763764
92Exertional dyspnea (HP:0002875)2.12650720
93Increased intramyocellular lipid droplets (HP:0012240)2.12283869
94Type I transferrin isoform profile (HP:0003642)2.10714720
95True hermaphroditism (HP:0010459)2.09166824
96CNS hypomyelination (HP:0003429)2.08309043
97Hypoplasia of the pons (HP:0012110)2.05595865
98Selective tooth agenesis (HP:0001592)2.05341072
99Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.02889847
100X-linked dominant inheritance (HP:0001423)2.02830661
101Cellular immunodeficiency (HP:0005374)2.02650349
102Muscle fiber inclusion bodies (HP:0100299)2.01277861
103Sparse eyelashes (HP:0000653)2.00904034
104Distal arthrogryposis (HP:0005684)2.00203862
105Horseshoe kidney (HP:0000085)1.98578435
106Hypoglycemic coma (HP:0001325)1.98507623
107Microvesicular hepatic steatosis (HP:0001414)1.98361906
108Renal cortical cysts (HP:0000803)1.96986904
109Hyperphosphaturia (HP:0003109)1.94368886
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92585534
111Absent thumb (HP:0009777)1.92314048
112Areflexia of lower limbs (HP:0002522)1.91855569
113Patent foramen ovale (HP:0001655)1.91627730
114Rimmed vacuoles (HP:0003805)1.90736776
115Slender long bone (HP:0003100)1.90104210
116Difficulty climbing stairs (HP:0003551)1.89655728
117Megaloblastic anemia (HP:0001889)1.89276606
118Medial flaring of the eyebrow (HP:0010747)1.88952061
119Abnormality of the calcaneus (HP:0008364)1.88773438
120Abnormality of subcutaneous fat tissue (HP:0001001)1.88377965
121Muscle fiber atrophy (HP:0100295)1.85433247
122Abnormality of the renal cortex (HP:0011035)1.85214087
123Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84938074
124Hyperglycinemia (HP:0002154)1.84115199
125Hyperinsulinemic hypoglycemia (HP:0000825)1.81150233
126Rhabdomyolysis (HP:0003201)1.79938612
127Increased muscle lipid content (HP:0009058)1.79440308
128Abnormality of the pons (HP:0007361)1.79404116
129Dicarboxylic aciduria (HP:0003215)1.79206240
130Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79206240
131Abnormality of the labia minora (HP:0012880)1.78656331
132Nephronophthisis (HP:0000090)1.77821317
133Myokymia (HP:0002411)1.76649122
134Abnormal protein glycosylation (HP:0012346)1.74868139
135Abnormal glycosylation (HP:0012345)1.74868139
136Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74868139
137Abnormal protein N-linked glycosylation (HP:0012347)1.74868139
138Abnormality of vitamin B metabolism (HP:0004340)1.72921143
139Poor suck (HP:0002033)1.68485312
140Reduced antithrombin III activity (HP:0001976)1.68285325
141Ketoacidosis (HP:0001993)1.66175617
142Hypomagnesemia (HP:0002917)1.65757458
143Abnormality of the vitamin B12 metabolism (HP:0004341)1.64677852
144Abnormality of aromatic amino acid family metabolism (HP:0004338)1.64655524
145Testicular atrophy (HP:0000029)1.63721647
146Sensory axonal neuropathy (HP:0003390)1.63602062
147Aplasia/hypoplasia of the uterus (HP:0008684)1.63422082
148Blindness (HP:0000618)1.59216310
149Abnormality of homocysteine metabolism (HP:0010919)1.59161006
150Homocystinuria (HP:0002156)1.59161006
151Progressive microcephaly (HP:0000253)1.59065728
152Abnormality of magnesium homeostasis (HP:0004921)1.55829707

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.18549041
2NME24.52113020
3WEE14.18038418
4EIF2AK13.44058569
5STK163.03841167
6TSSK62.41350766
7TLK12.32257643
8PLK42.31645475
9TESK22.31364786
10EIF2AK32.25808902
11NME12.24819476
12CDC72.21519931
13ACVR1B2.20938202
14VRK22.20644170
15MAP3K122.15255908
16SRPK12.14713426
17BMPR1B2.07256364
18BRSK22.03440126
19NEK11.96711219
20WNK31.87282188
21DYRK31.84832360
22RPS6KA41.84591261
23NEK21.80975918
24PIM21.73726508
25PHKG11.72564174
26PHKG21.72564174
27FRK1.71798627
28VRK11.66355174
29TESK11.65072455
30SCYL21.60633361
31PLK11.57604267
32ADRBK21.51151568
33CAMKK21.50453246
34LIMK11.48364280
35PBK1.47488183
36KDR1.47227242
37PASK1.46179135
38ARAF1.45804628
39MAP4K21.40869413
40MYLK1.40426341
41PLK31.39944099
42BRAF1.37182290
43MAP3K41.36299263
44NUAK11.35022393
45GRK11.33889856
46AURKB1.33219800
47EPHA21.31391336
48TTK1.30056953
49AURKA1.26503992
50MAP2K71.25470693
51ZAK1.19589421
52BRSK11.16249856
53WNK41.13303842
54CASK1.10645520
55TNIK1.09848561
56INSRR1.04148989
57MKNK11.00341834
58MAP3K80.99970657
59RPS6KB20.99628627
60PNCK0.99480115
61OXSR10.97756672
62CSNK1G30.97561867
63PAK30.97434151
64TRIM280.97070817
65CSNK1G20.95948150
66BCKDK0.95680127
67IRAK30.95039348
68LRRK20.94306110
69STK38L0.93697702
70ILK0.92757800
71ERBB30.92724559
72PRKCG0.91067055
73DYRK20.89963249
74CDK70.89885221
75MAP3K110.89524837
76STK390.87615824
77CSNK1G10.86333681
78ABL20.84824774
79PLK20.83152168
80CHEK20.77463879
81ATR0.76525852
82PAK10.75713659
83RPS6KA50.72044888
84TAOK30.70861049
85PAK40.69602501
86CSNK2A10.68968214
87MKNK20.68641639
88CSNK2A20.66310274
89PDK40.65172814
90PDK30.65172814
91ZAP700.65067608
92MINK10.64150362
93BLK0.63269907
94TIE10.62934223
95CCNB10.62882096
96PRKCI0.62682844
97CHEK10.61309135
98ADRBK10.60311510
99RAF10.58598104
100MAPK130.58541423
101CAMK10.57280768
102MARK10.56722827
103PKN10.56133987
104DMPK0.54858399
105PIM10.54008840
106PRKCE0.53428534
107MAPKAPK30.53297511
108CDK40.53041112
109MARK30.52858875
110LATS20.52328825
111CAMK2D0.51413348
112OBSCN0.50712934
113CAMK2A0.50171715
114EIF2AK20.49369053
115GRK70.48111636
116CSNK1A1L0.47967320
117TAF10.47816420
118TAOK20.46117712
119CDK30.45815195
120PRKACA0.44617383
121CAMK2G0.44427141
122STK30.44145460
123CSNK1A10.43652079
124TTN0.42449668
125MAP2K20.41876228
126CDK20.41138290
127MAP2K30.38491783
128PINK10.38122978
129MAP3K50.38063177
130MUSK0.36518753
131PIK3CG0.35695484
132CDK80.35381910
133PDK20.34187689
134FLT30.34042496
135MAP3K30.32268664
136JAK30.30087718
137IRAK40.29651263
138ATM0.27939420
139STK240.27808122
140CDK190.27217302
141STK40.26544856
142MAP4K10.26042153
143TGFBR10.26028962
144CSNK1E0.25535895
145CDK10.20664789
146MST40.19919136
147ALK0.19636752
148DAPK30.19283618

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.01675772
2Ribosome_Homo sapiens_hsa030104.49329936
3RNA polymerase_Homo sapiens_hsa030204.12093314
4DNA replication_Homo sapiens_hsa030303.69040907
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53964039
6Mismatch repair_Homo sapiens_hsa034303.07577870
7Spliceosome_Homo sapiens_hsa030403.01317170
8RNA transport_Homo sapiens_hsa030132.88514815
9Pyrimidine metabolism_Homo sapiens_hsa002402.73773567
10Protein export_Homo sapiens_hsa030602.58178240
11Oxidative phosphorylation_Homo sapiens_hsa001902.47511342
12Parkinsons disease_Homo sapiens_hsa050122.33339275
13Nucleotide excision repair_Homo sapiens_hsa034202.33190747
14Homologous recombination_Homo sapiens_hsa034402.15600589
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05493811
16Base excision repair_Homo sapiens_hsa034102.00609327
17Cell cycle_Homo sapiens_hsa041101.95252077
18Huntingtons disease_Homo sapiens_hsa050161.91732736
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58653533
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56400624
21RNA degradation_Homo sapiens_hsa030181.55237769
22Basal transcription factors_Homo sapiens_hsa030221.52137759
23Purine metabolism_Homo sapiens_hsa002301.51207532
24Alzheimers disease_Homo sapiens_hsa050101.47292225
25Propanoate metabolism_Homo sapiens_hsa006401.45912382
26Folate biosynthesis_Homo sapiens_hsa007901.45411186
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45263457
28One carbon pool by folate_Homo sapiens_hsa006701.44608038
29Sulfur metabolism_Homo sapiens_hsa009201.39103619
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38563216
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36143068
32p53 signaling pathway_Homo sapiens_hsa041151.32613908
33Vitamin B6 metabolism_Homo sapiens_hsa007501.31106685
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27337609
35Epstein-Barr virus infection_Homo sapiens_hsa051691.24758532
36Fanconi anemia pathway_Homo sapiens_hsa034601.15236407
37Butanoate metabolism_Homo sapiens_hsa006501.09806526
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09124865
39Pentose phosphate pathway_Homo sapiens_hsa000301.03105105
40Sulfur relay system_Homo sapiens_hsa041221.00298560
41Nitrogen metabolism_Homo sapiens_hsa009100.98808379
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98738899
43mRNA surveillance pathway_Homo sapiens_hsa030150.98487385
44Antigen processing and presentation_Homo sapiens_hsa046120.95323876
45Regulation of autophagy_Homo sapiens_hsa041400.93813622
46Fatty acid elongation_Homo sapiens_hsa000620.92220741
47Peroxisome_Homo sapiens_hsa041460.88326275
48Legionellosis_Homo sapiens_hsa051340.87925629
49Non-homologous end-joining_Homo sapiens_hsa034500.87672761
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81984708
51Systemic lupus erythematosus_Homo sapiens_hsa053220.79981262
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.77897727
53Oocyte meiosis_Homo sapiens_hsa041140.77817406
54Cardiac muscle contraction_Homo sapiens_hsa042600.77790032
55Phototransduction_Homo sapiens_hsa047440.76067661
56Tryptophan metabolism_Homo sapiens_hsa003800.73779956
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72357184
58Nicotine addiction_Homo sapiens_hsa050330.71605223
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69927041
60Carbon metabolism_Homo sapiens_hsa012000.68655403
61Fructose and mannose metabolism_Homo sapiens_hsa000510.67997135
62Selenocompound metabolism_Homo sapiens_hsa004500.67483122
63Biosynthesis of amino acids_Homo sapiens_hsa012300.66408415
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64363726
65Viral carcinogenesis_Homo sapiens_hsa052030.63471441
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60990187
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59565943
68Chemical carcinogenesis_Homo sapiens_hsa052040.59127720
69Herpes simplex infection_Homo sapiens_hsa051680.56916297
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.55583947
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54633118
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54515689
73Glutathione metabolism_Homo sapiens_hsa004800.53989463
74Caffeine metabolism_Homo sapiens_hsa002320.53621870
75Fatty acid degradation_Homo sapiens_hsa000710.51819263
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49301087
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.47128247
78Galactose metabolism_Homo sapiens_hsa000520.46924031
79Metabolic pathways_Homo sapiens_hsa011000.46307753
80Shigellosis_Homo sapiens_hsa051310.45866725
81Synaptic vesicle cycle_Homo sapiens_hsa047210.44462614
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44083538
83Circadian rhythm_Homo sapiens_hsa047100.43672798
84Retinol metabolism_Homo sapiens_hsa008300.42046166
85beta-Alanine metabolism_Homo sapiens_hsa004100.41995855
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40287881
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39443369
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38692134
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.38689721
90N-Glycan biosynthesis_Homo sapiens_hsa005100.38291146
91GABAergic synapse_Homo sapiens_hsa047270.37672818
92Mineral absorption_Homo sapiens_hsa049780.37369606
93Thyroid cancer_Homo sapiens_hsa052160.37090599
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36797691
95Type I diabetes mellitus_Homo sapiens_hsa049400.36735350
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36706479
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.36444369
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36145493
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36092601
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35952504
101HTLV-I infection_Homo sapiens_hsa051660.35087846
102Linoleic acid metabolism_Homo sapiens_hsa005910.35001280
103Fatty acid metabolism_Homo sapiens_hsa012120.34609047
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33470377
105Steroid biosynthesis_Homo sapiens_hsa001000.33451140
106Vibrio cholerae infection_Homo sapiens_hsa051100.33360951
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32102871
108Apoptosis_Homo sapiens_hsa042100.31332248
109Morphine addiction_Homo sapiens_hsa050320.30172407
110Alcoholism_Homo sapiens_hsa050340.28663966
111Tyrosine metabolism_Homo sapiens_hsa003500.28108535
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27917238
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27099215
114Measles_Homo sapiens_hsa051620.26886293
115Allograft rejection_Homo sapiens_hsa053300.26574613
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25850107
117Graft-versus-host disease_Homo sapiens_hsa053320.24412034
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24017539
119Insulin secretion_Homo sapiens_hsa049110.23569439
120Olfactory transduction_Homo sapiens_hsa047400.23276238
121Taste transduction_Homo sapiens_hsa047420.21779888
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20918043
123HIF-1 signaling pathway_Homo sapiens_hsa040660.20816174
124Fat digestion and absorption_Homo sapiens_hsa049750.18984158
125Asthma_Homo sapiens_hsa053100.18744415
126Arginine and proline metabolism_Homo sapiens_hsa003300.18393617
127Dopaminergic synapse_Homo sapiens_hsa047280.17995858
128Hepatitis B_Homo sapiens_hsa051610.17239240
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16758633
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14614430
131Pyruvate metabolism_Homo sapiens_hsa006200.13701810
132Rheumatoid arthritis_Homo sapiens_hsa053230.12443865
133Primary immunodeficiency_Homo sapiens_hsa053400.11640462
134Viral myocarditis_Homo sapiens_hsa054160.10413768
135Phagosome_Homo sapiens_hsa041450.09621381
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.09173895
137NF-kappa B signaling pathway_Homo sapiens_hsa040640.08566236
138Influenza A_Homo sapiens_hsa051640.08046577
139Small cell lung cancer_Homo sapiens_hsa052220.06640736
140Arachidonic acid metabolism_Homo sapiens_hsa005900.04767731
141Collecting duct acid secretion_Homo sapiens_hsa049660.04344265
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02426306
143Lysosome_Homo sapiens_hsa041420.02358233
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.02030854
145Bladder cancer_Homo sapiens_hsa052190.01246465

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