RUVBL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.94384054
2DNA unwinding involved in DNA replication (GO:0006268)4.82483270
3DNA deamination (GO:0045006)4.77038707
4DNA replication initiation (GO:0006270)4.74039253
5DNA strand elongation (GO:0022616)4.71914747
6nucleobase biosynthetic process (GO:0046112)4.58666695
7telomere maintenance via semi-conservative replication (GO:0032201)4.55960186
8formation of translation preinitiation complex (GO:0001731)4.53035115
9ribosomal small subunit assembly (GO:0000028)4.47326458
10maturation of SSU-rRNA (GO:0030490)4.41949452
11regulation of mitochondrial translation (GO:0070129)4.29758936
12purine nucleobase biosynthetic process (GO:0009113)4.24837685
13protein localization to kinetochore (GO:0034501)4.21043257
14DNA replication checkpoint (GO:0000076)4.15936477
15IMP biosynthetic process (GO:0006188)4.06169975
16ribosome assembly (GO:0042255)4.03238779
17ribosome biogenesis (GO:0042254)4.01721525
18telomere maintenance via recombination (GO:0000722)4.00033515
19folic acid-containing compound biosynthetic process (GO:0009396)3.98429652
20regulation of translational fidelity (GO:0006450)3.97654833
21peptidyl-arginine omega-N-methylation (GO:0035247)3.96661934
22mitotic nuclear envelope disassembly (GO:0007077)3.94036765
23DNA replication-dependent nucleosome organization (GO:0034723)3.92902881
24DNA replication-dependent nucleosome assembly (GO:0006335)3.92902881
25mitotic metaphase plate congression (GO:0007080)3.92439903
26viral transcription (GO:0019083)3.92419149
27translational termination (GO:0006415)3.87582659
28ribosomal large subunit biogenesis (GO:0042273)3.84254664
29mitotic recombination (GO:0006312)3.84165151
30ribonucleoprotein complex biogenesis (GO:0022613)3.83548580
31telomere maintenance via telomere lengthening (GO:0010833)3.73282882
32translational initiation (GO:0006413)3.67063930
33translational elongation (GO:0006414)3.66785734
34nucleobase-containing small molecule interconversion (GO:0015949)3.66551057
35nuclear envelope disassembly (GO:0051081)3.63195587
36membrane disassembly (GO:0030397)3.63195587
37ribosomal small subunit biogenesis (GO:0042274)3.63077659
38protein localization to chromosome, centromeric region (GO:0071459)3.62799528
39protein maturation by protein folding (GO:0022417)3.59584238
40IMP metabolic process (GO:0046040)3.58896846
41GDP-mannose metabolic process (GO:0019673)3.58186499
42CENP-A containing nucleosome assembly (GO:0034080)3.56142653
43spliceosomal snRNP assembly (GO:0000387)3.55702700
44chromatin remodeling at centromere (GO:0031055)3.54596256
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.54435380
46proline biosynthetic process (GO:0006561)3.54397066
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.52597434
48establishment of viral latency (GO:0019043)3.51943332
49pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.51351478
50nuclear pore organization (GO:0006999)3.49950966
51rRNA processing (GO:0006364)3.49052402
52mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48692017
53histone arginine methylation (GO:0034969)3.43507760
54pseudouridine synthesis (GO:0001522)3.37903729
55rRNA metabolic process (GO:0016072)3.37239216
56chaperone-mediated protein transport (GO:0072321)3.37136134
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.37117772
58pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.36357627
59metaphase plate congression (GO:0051310)3.36053871
60DNA replication-independent nucleosome assembly (GO:0006336)3.34360472
61DNA replication-independent nucleosome organization (GO:0034724)3.34360472
62guanosine-containing compound biosynthetic process (GO:1901070)3.34295338
63proteasome assembly (GO:0043248)3.30455129
64UTP biosynthetic process (GO:0006228)3.30142626
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.26094427
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.23998849
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22911504
68pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.20945854
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.19714988
70cellular component biogenesis (GO:0044085)3.19159817
71protein targeting to mitochondrion (GO:0006626)3.18951623
72tRNA aminoacylation for protein translation (GO:0006418)3.18775403
73peptidyl-arginine methylation (GO:0018216)3.18183194
74peptidyl-arginine N-methylation (GO:0035246)3.18183194
75nuclear pore complex assembly (GO:0051292)3.18159120
76mitotic sister chromatid segregation (GO:0000070)3.17943661
77kinetochore organization (GO:0051383)3.17576769
78ATP synthesis coupled proton transport (GO:0015986)3.15895702
79energy coupled proton transport, down electrochemical gradient (GO:0015985)3.15895702
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14958771
81positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14871139
82establishment of protein localization to mitochondrial membrane (GO:0090151)3.14607972
83establishment of integrated proviral latency (GO:0075713)3.13899221
84cotranslational protein targeting to membrane (GO:0006613)3.13448356
85protein targeting to ER (GO:0045047)3.13065027
86nuclear envelope reassembly (GO:0031468)3.12074551
87mitotic nuclear envelope reassembly (GO:0007084)3.12074551
88regulation of cellular amino acid metabolic process (GO:0006521)3.10908773
89transcription-coupled nucleotide-excision repair (GO:0006283)3.10899094
90amino acid activation (GO:0043038)3.10777960
91tRNA aminoacylation (GO:0043039)3.10777960
92cellular protein complex disassembly (GO:0043624)3.10258867
93rRNA modification (GO:0000154)3.09808691
94regulation of spindle organization (GO:0090224)3.09733838
95somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09144685
96somatic hypermutation of immunoglobulin genes (GO:0016446)3.09144685
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08964926
98deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07866521
99histone exchange (GO:0043486)3.05937690
100* DNA duplex unwinding (GO:0032508)3.05379859
101sister chromatid segregation (GO:0000819)3.05225243
102folic acid metabolic process (GO:0046655)3.05200616
103* DNA geometric change (GO:0032392)3.04772192
104viral life cycle (GO:0019058)3.04722297
105establishment of chromosome localization (GO:0051303)3.04571571
106pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.03639957
107G1/S transition of mitotic cell cycle (GO:0000082)2.99972531
108cell cycle G1/S phase transition (GO:0044843)2.99972531
109oxidative phosphorylation (GO:0006119)2.98821192
110positive regulation of ligase activity (GO:0051351)2.98528526
111kinetochore assembly (GO:0051382)2.98347509
112establishment of protein localization to mitochondrion (GO:0072655)2.97998990
113base-excision repair (GO:0006284)2.97403656
114CTP metabolic process (GO:0046036)2.96577574
115CTP biosynthetic process (GO:0006241)2.96577574
116GTP biosynthetic process (GO:0006183)2.96387294
117spliceosomal complex assembly (GO:0000245)2.96317373
118signal transduction involved in DNA damage checkpoint (GO:0072422)2.96182241
119signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96182241
120regulation of ubiquitin-protein transferase activity (GO:0051438)2.95936719
121establishment of protein localization to endoplasmic reticulum (GO:0072599)2.95931292
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.95904474
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.95904474
124translation (GO:0006412)2.95760838
125DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95332567
126signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.94771534
127signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.94771534
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.94771534
129RNA splicing, via transesterification reactions (GO:0000375)2.94549014
130attachment of spindle microtubules to kinetochore (GO:0008608)2.94482381
131pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.94474056
132mRNA splicing, via spliceosome (GO:0000398)2.94392488
133RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94392488
134negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94365467
135negative regulation of ligase activity (GO:0051352)2.94365467
136negative regulation of chromosome segregation (GO:0051985)2.94258702
137negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.94206212
138regulation of translational termination (GO:0006449)2.93582527
139UTP metabolic process (GO:0046051)2.93559702
140protein localization to endoplasmic reticulum (GO:0070972)2.93053997
141regulation of nuclear cell cycle DNA replication (GO:0033262)2.92168104
142negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90691514
143negative regulation of sister chromatid segregation (GO:0033046)2.90691514
144negative regulation of mitotic sister chromatid separation (GO:2000816)2.90691514
145negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90691514
146mitotic chromosome condensation (GO:0007076)2.90502986
147protein complex disassembly (GO:0043241)2.90471997
148viral mRNA export from host cell nucleus (GO:0046784)2.89566324
149telomere organization (GO:0032200)2.89078515
150telomere maintenance (GO:0000723)2.88118925
151regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87905794
152maturation of 5.8S rRNA (GO:0000460)2.85897692

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.95173409
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.41694985
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.94547225
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.60007101
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40086117
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.14709428
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94852450
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94016751
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90122955
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89876041
11* EST1_17652178_ChIP-ChIP_JURKAT_Human2.85677714
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.83671550
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82324871
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.68952223
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53566005
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42906341
17XRN2_22483619_ChIP-Seq_HELA_Human2.41287535
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35717376
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33555078
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32023610
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15110067
22* VDR_23849224_ChIP-Seq_CD4+_Human2.12896944
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03375146
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03284325
25AR_21909140_ChIP-Seq_LNCAP_Human1.95245996
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91775677
27FOXP3_21729870_ChIP-Seq_TREG_Human1.91478363
28DCP1A_22483619_ChIP-Seq_HELA_Human1.90803440
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89635934
30GABP_19822575_ChIP-Seq_HepG2_Human1.88008629
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87131538
32* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85874442
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.84298009
34TTF2_22483619_ChIP-Seq_HELA_Human1.81206276
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80396387
36ZNF263_19887448_ChIP-Seq_K562_Human1.79656698
37MYC_22102868_ChIP-Seq_BL_Human1.71421336
38CIITA_25753668_ChIP-Seq_RAJI_Human1.68787293
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.67657201
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.66337648
41* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65951033
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65440074
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63296021
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59678889
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57847512
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57814436
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52786028
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52071807
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50421635
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49813699
51KDM5A_27292631_Chip-Seq_BREAST_Human1.47167284
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46182251
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45715703
54* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44459736
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43067012
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40757699
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39658908
58ELK1_19687146_ChIP-ChIP_HELA_Human1.37794994
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35498672
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.33883521
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33552319
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31632914
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31392692
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31303075
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.26605028
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26335463
67* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25209584
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23423006
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22128925
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22034370
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20599448
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19602710
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18175675
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15201353
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15165722
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13386021
77TFEB_21752829_ChIP-Seq_HELA_Human1.13327844
78* FOXP1_21924763_ChIP-Seq_HESCs_Human1.13278636
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13150275
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12913140
81* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12314225
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11880336
83VDR_21846776_ChIP-Seq_THP-1_Human1.09067962
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.05982770
85* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05826245
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05293666
87P68_20966046_ChIP-Seq_HELA_Human1.03815688
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03583316
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03011175
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02193867
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01435962
92TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01370790
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.99831096
94* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99755773
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99251745
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99163579
97* ELF1_20517297_ChIP-Seq_JURKAT_Human0.98453398
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97656868
99TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97119680
100LXR_22292898_ChIP-Seq_THP-1_Human0.95466206
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93225954
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92863079
103RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92500609
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92410989
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91241236
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90679005
107OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90041308
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.89746119
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87793339
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87711549
111RACK7_27058665_Chip-Seq_MCF-7_Human0.87161878
112NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86731022
113MYC_18940864_ChIP-ChIP_HL60_Human0.86730788
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86663686
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86177265
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85946057
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85443865
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85443865
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85443865
120TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.82782774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.60474762
2MP0003111_abnormal_nucleus_morphology4.70037707
3MP0010094_abnormal_chromosome_stability4.66984082
4MP0004957_abnormal_blastocyst_morpholog4.61892786
5MP0003077_abnormal_cell_cycle4.13101997
6MP0008057_abnormal_DNA_replication3.72665184
7MP0008058_abnormal_DNA_repair3.41501660
8MP0008007_abnormal_cellular_replicative3.03014721
9MP0008932_abnormal_embryonic_tissue2.75556488
10MP0001730_embryonic_growth_arrest2.59413471
11MP0010352_gastrointestinal_tract_polyps2.52653156
12MP0002396_abnormal_hematopoietic_system2.52413152
13MP0003123_paternal_imprinting2.38192353
14MP0000350_abnormal_cell_proliferation2.35219464
15MP0009379_abnormal_foot_pigmentation2.02125799
16MP0003786_premature_aging1.95997959
17MP0003806_abnormal_nucleotide_metabolis1.89491271
18MP0005380_embryogenesis_phenotype1.87613925
19MP0001672_abnormal_embryogenesis/_devel1.87613925
20MP0001697_abnormal_embryo_size1.86572559
21MP0010307_abnormal_tumor_latency1.84133995
22MP0008877_abnormal_DNA_methylation1.81464268
23MP0000678_abnormal_parathyroid_gland1.78635290
24MP0002080_prenatal_lethality1.75793125
25MP0009697_abnormal_copulation1.75282761
26MP0000490_abnormal_crypts_of1.73466250
27MP0005451_abnormal_body_composition1.71451307
28MP0003984_embryonic_growth_retardation1.70892600
29MP0002088_abnormal_embryonic_growth/wei1.66737761
30MP0002085_abnormal_embryonic_tissue1.65284439
31MP0000313_abnormal_cell_death1.57356159
32MP0004233_abnormal_muscle_weight1.55179573
33MP0003718_maternal_effect1.54901680
34MP0002084_abnormal_developmental_patter1.51227874
35MP0002019_abnormal_tumor_incidence1.48194952
36MP0002877_abnormal_melanocyte_morpholog1.48090681
37MP0010030_abnormal_orbit_morphology1.46082481
38MP0002086_abnormal_extraembryonic_tissu1.44942872
39MP0004197_abnormal_fetal_growth/weight/1.44010092
40MP0004808_abnormal_hematopoietic_stem1.41794748
41MP0003567_abnormal_fetal_cardiomyocyte1.40776072
42MP0001293_anophthalmia1.35356886
43MP0001727_abnormal_embryo_implantation1.33787452
44MP0001545_abnormal_hematopoietic_system1.32166586
45MP0005397_hematopoietic_system_phenotyp1.32166586
46MP0008789_abnormal_olfactory_epithelium1.31474564
47MP0002653_abnormal_ependyma_morphology1.30625829
48MP0009333_abnormal_splenocyte_physiolog1.25700684
49MP0001661_extended_life_span1.23557909
50MP0003315_abnormal_perineum_morphology1.21770249
51MP0004133_heterotaxia1.20843747
52MP0002210_abnormal_sex_determination1.19871430
53MP0002249_abnormal_larynx_morphology1.18936928
54MP0001529_abnormal_vocalization1.16979340
55MP0001145_abnormal_male_reproductive1.13896759
56MP0000358_abnormal_cell_content/1.13439311
57MP0005076_abnormal_cell_differentiation1.12454138
58MP0008260_abnormal_autophagy1.10880675
59MP0000537_abnormal_urethra_morphology1.10714888
60MP0005623_abnormal_meninges_morphology1.09226274
61MP0003119_abnormal_digestive_system1.08979860
62MP0000703_abnormal_thymus_morphology1.07197463
63MP0000566_synostosis1.06356525
64MP0005394_taste/olfaction_phenotype1.06184613
65MP0005499_abnormal_olfactory_system1.06184613
66MP0002160_abnormal_reproductive_system1.03292848
67MP0003890_abnormal_embryonic-extraembry1.02915126
68MP0004185_abnormal_adipocyte_glucose1.02300499
69MP0003121_genomic_imprinting1.02119313
70MP0002234_abnormal_pharynx_morphology1.00237651
71MP0008875_abnormal_xenobiotic_pharmacok0.99432755
72MP0002722_abnormal_immune_system0.98092944
73MP0005083_abnormal_biliary_tract0.97870499
74MP0001929_abnormal_gametogenesis0.97841772
75MP0003763_abnormal_thymus_physiology0.96703014
76MP0009053_abnormal_anal_canal0.96433123
77MP0006054_spinal_hemorrhage0.96268733
78MP0000858_altered_metastatic_potential0.95485653
79MP0002398_abnormal_bone_marrow0.95015560
80MP0001346_abnormal_lacrimal_gland0.94439201
81MP0006292_abnormal_olfactory_placode0.93687855
82MP0009672_abnormal_birth_weight0.92707701
83MP0001881_abnormal_mammary_gland0.91926093
84MP0000653_abnormal_sex_gland0.91308283
85MP0003186_abnormal_redox_activity0.89976263
86MP0000689_abnormal_spleen_morphology0.89829669
87MP0002796_impaired_skin_barrier0.88831130
88MP0002132_abnormal_respiratory_system0.88374084
89MP0004858_abnormal_nervous_system0.86731248
90MP0002938_white_spotting0.85727712
91MP0000467_abnormal_esophagus_morphology0.85033087
92MP0002163_abnormal_gland_morphology0.84930855
93MP0005384_cellular_phenotype0.84626111
94MP0004147_increased_porphyrin_level0.84519399
95MP0005023_abnormal_wound_healing0.84426581
96MP0005330_cardiomyopathy0.83563906
97MP0002111_abnormal_tail_morphology0.83552593
98MP0003942_abnormal_urinary_system0.81381245
99MP0001915_intracranial_hemorrhage0.80226237
100MP0008995_early_reproductive_senescence0.79486918
101MP0003221_abnormal_cardiomyocyte_apopto0.79045012
102MP0000372_irregular_coat_pigmentation0.78251399
103MP0002429_abnormal_blood_cell0.77434078
104MP0000762_abnormal_tongue_morphology0.77080278
105MP0003941_abnormal_skin_development0.76705908
106MP0005389_reproductive_system_phenotype0.76190643
107MP0005621_abnormal_cell_physiology0.74760873
108MP0006035_abnormal_mitochondrial_morpho0.74517096
109MP0001849_ear_inflammation0.73908793
110MP0003385_abnormal_body_wall0.73344512
111MP0001853_heart_inflammation0.72820737
112MP0003566_abnormal_cell_adhesion0.69751181
113MP0000477_abnormal_intestine_morphology0.69120079
114MP0002697_abnormal_eye_size0.68688714
115MP0000428_abnormal_craniofacial_morphol0.68491999
116MP0000747_muscle_weakness0.67702887
117MP0009278_abnormal_bone_marrow0.67485967
118MP0001119_abnormal_female_reproductive0.67412956
119MP0003705_abnormal_hypodermis_morpholog0.65949377
120MP0000750_abnormal_muscle_regeneration0.65750524
121MP0005075_abnormal_melanosome_morpholog0.65405242
122MP0001764_abnormal_homeostasis0.65041898
123MP0010771_integument_phenotype0.64244822
124MP0009703_decreased_birth_body0.63964078
125MP0006036_abnormal_mitochondrial_physio0.63352289
126MP0005266_abnormal_metabolism0.63243836
127MP0002092_abnormal_eye_morphology0.63098590
128MP0005408_hypopigmentation0.62784180
129MP0001286_abnormal_eye_development0.58035107
130MP0000716_abnormal_immune_system0.57937070
131MP0008770_decreased_survivor_rate0.54918771
132MP0005501_abnormal_skin_physiology0.54570848
133MP0003937_abnormal_limbs/digits/tail_de0.53692729
134MP0002269_muscular_atrophy0.52030282
135MP0001919_abnormal_reproductive_system0.52025173
136MP0003698_abnormal_male_reproductive0.50774117
137MP0002161_abnormal_fertility/fecundity0.47663319
138MP0000049_abnormal_middle_ear0.46234938
139MP0002925_abnormal_cardiovascular_devel0.46144663

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.92275641
2Reticulocytopenia (HP:0001896)4.36968861
3Abnormality of cells of the erythroid lineage (HP:0012130)4.35378106
4Abnormal number of erythroid precursors (HP:0012131)4.21039816
5Breast hypoplasia (HP:0003187)4.12588984
6Abnormal mitochondria in muscle tissue (HP:0008316)3.97018019
7Oral leukoplakia (HP:0002745)3.95862041
8Selective tooth agenesis (HP:0001592)3.87271156
9Colon cancer (HP:0003003)3.76101759
10Acute necrotizing encephalopathy (HP:0006965)3.66853340
11Abnormality of glycolysis (HP:0004366)3.64458003
12Aplastic anemia (HP:0001915)3.55286667
13Microvesicular hepatic steatosis (HP:0001414)3.49579188
14Ependymoma (HP:0002888)3.46664597
15Degeneration of anterior horn cells (HP:0002398)3.45173880
16Abnormality of the anterior horn cell (HP:0006802)3.45173880
17Acute encephalopathy (HP:0006846)3.45108073
18Carpal bone hypoplasia (HP:0001498)3.40000970
19Hepatocellular necrosis (HP:0001404)3.39935528
20Rough bone trabeculation (HP:0100670)3.38049037
21Increased serum pyruvate (HP:0003542)3.30201786
22Mitochondrial inheritance (HP:0001427)3.25937534
23Patellar aplasia (HP:0006443)3.25033783
24Medulloblastoma (HP:0002885)3.24473506
25Increased CSF lactate (HP:0002490)3.21182169
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.18044008
27Cerebral hypomyelination (HP:0006808)3.17596021
28Hepatic necrosis (HP:0002605)3.12956771
29Chromsome breakage (HP:0040012)3.11199640
30Aplasia/Hypoplasia of the patella (HP:0006498)3.08746282
31Ragged-red muscle fibers (HP:0003200)3.01167253
32Meckel diverticulum (HP:0002245)2.99740551
33Absent thumb (HP:0009777)2.93605578
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93567065
35Macrocytic anemia (HP:0001972)2.92841335
36Broad distal phalanx of finger (HP:0009836)2.90610052
37Abnormality of the ileum (HP:0001549)2.87838108
38Microretrognathia (HP:0000308)2.86206619
39Abnormal gallbladder physiology (HP:0012438)2.84967569
40Cholecystitis (HP:0001082)2.84967569
41Increased intramyocellular lipid droplets (HP:0012240)2.84124068
42Agnosia (HP:0010524)2.83310248
43Increased serum lactate (HP:0002151)2.80735607
44Abnormality of the preputium (HP:0100587)2.77353542
45Type I transferrin isoform profile (HP:0003642)2.77233491
46Abnormality of chromosome stability (HP:0003220)2.74769171
47Pallor (HP:0000980)2.73677231
48Neoplasm of the pancreas (HP:0002894)2.73560151
49Trismus (HP:0000211)2.69919709
50Exercise intolerance (HP:0003546)2.69636683
51Cerebral edema (HP:0002181)2.68086425
52Multiple enchondromatosis (HP:0005701)2.65808852
53Lactic acidosis (HP:0003128)2.64092374
54Absent radius (HP:0003974)2.62959617
55Progressive macrocephaly (HP:0004481)2.58548736
56Premature graying of hair (HP:0002216)2.58259151
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.53054474
5811 pairs of ribs (HP:0000878)2.52755812
59Impulsivity (HP:0100710)2.50890548
60Increased muscle lipid content (HP:0009058)2.50307933
61Bone marrow hypocellularity (HP:0005528)2.49747324
62Abnormal number of incisors (HP:0011064)2.49734684
63Premature ovarian failure (HP:0008209)2.48434813
64Myelodysplasia (HP:0002863)2.47482487
65Rhabdomyosarcoma (HP:0002859)2.47170100
66Duodenal stenosis (HP:0100867)2.44181728
67Small intestinal stenosis (HP:0012848)2.44181728
68Absent forearm bone (HP:0003953)2.43512134
69Aplasia involving forearm bones (HP:0009822)2.43512134
70Abnormal respiratory motile cilium physiology (HP:0012261)2.42161728
71Abnormal respiratory epithelium morphology (HP:0012253)2.37680524
72Abnormal respiratory motile cilium morphology (HP:0005938)2.37680524
73Tracheoesophageal fistula (HP:0002575)2.37487111
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.36498894
75Abnormal protein glycosylation (HP:0012346)2.36204505
76Abnormal glycosylation (HP:0012345)2.36204505
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36204505
78Abnormal protein N-linked glycosylation (HP:0012347)2.36204505
79Cellular immunodeficiency (HP:0005374)2.35893186
80Increased hepatocellular lipid droplets (HP:0006565)2.34191970
81Supernumerary spleens (HP:0009799)2.33580768
82Basal cell carcinoma (HP:0002671)2.33278000
83Testicular atrophy (HP:0000029)2.31931044
84Abnormal trabecular bone morphology (HP:0100671)2.31031328
85Atresia of the external auditory canal (HP:0000413)2.24797056
86Horseshoe kidney (HP:0000085)2.24370307
87Sloping forehead (HP:0000340)2.24271733
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23911512
89Lipid accumulation in hepatocytes (HP:0006561)2.23153966
90Thrombocytosis (HP:0001894)2.22374500
91Abnormal lung lobation (HP:0002101)2.20995345
92Atrophy/Degeneration involving motor neurons (HP:0007373)2.18498935
93Secondary amenorrhea (HP:0000869)2.18215814
94Missing ribs (HP:0000921)2.14001069
95Rhinitis (HP:0012384)2.13940083
96Truncus arteriosus (HP:0001660)2.10138902
97Progressive muscle weakness (HP:0003323)2.07365337
98Increased nuchal translucency (HP:0010880)2.06554583
99Abdominal situs inversus (HP:0003363)2.05525419
100Abnormality of abdominal situs (HP:0011620)2.05525419
101Abnormality of the duodenum (HP:0002246)2.05477081
102Abnormality of the labia minora (HP:0012880)2.04662777
103Cleft eyelid (HP:0000625)2.03881855
104Respiratory failure (HP:0002878)2.03473798
105Aplasia/hypoplasia of the humerus (HP:0006507)2.03442604
106Glioma (HP:0009733)2.02315632
107Triphalangeal thumb (HP:0001199)2.01563882
108Hyperacusis (HP:0010780)2.01067545
109Pancytopenia (HP:0001876)2.00753380
110Astrocytoma (HP:0009592)1.99622183
111Abnormality of the astrocytes (HP:0100707)1.99622183
112Chronic bronchitis (HP:0004469)1.98585870
113Facial cleft (HP:0002006)1.97861668
114Abnormal ciliary motility (HP:0012262)1.97145713
115Slender long bone (HP:0003100)1.96453513
116Emotional lability (HP:0000712)1.96416184
117Proximal placement of thumb (HP:0009623)1.95888866
118Dynein arm defect of respiratory motile cilia (HP:0012255)1.95459251
119Absent/shortened dynein arms (HP:0200106)1.95459251
120Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94587132
121Squamous cell carcinoma (HP:0002860)1.94408090
122Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93271080
123Amaurosis fugax (HP:0100576)1.91966843
124Abnormality of reticulocytes (HP:0004312)1.91857301
125Reduced antithrombin III activity (HP:0001976)1.90242499
126Megaloblastic anemia (HP:0001889)1.89974964
127Deviation of the thumb (HP:0009603)1.89184255
128Lymphoma (HP:0002665)1.88897210
129Neoplasm of the colon (HP:0100273)1.88417026
130Insomnia (HP:0100785)1.88186257
131Renal Fanconi syndrome (HP:0001994)1.86826247
132Neoplasm of the oral cavity (HP:0100649)1.86388080
133Ectopic kidney (HP:0000086)1.86342924
134Occipital encephalocele (HP:0002085)1.86292088
135Neoplasm of striated muscle (HP:0009728)1.86279312
136Spinal muscular atrophy (HP:0007269)1.85878893
137Abnormality of the carotid arteries (HP:0005344)1.84596159
138Hypokinesia (HP:0002375)1.84113013
139Glossoptosis (HP:0000162)1.83920776
140Self-mutilation (HP:0000742)1.81595181
141Prominent nose (HP:0000448)1.81322338
142Opisthotonus (HP:0002179)1.81053121
143Hypoplasia of the radius (HP:0002984)1.80974805
144Cafe-au-lait spot (HP:0000957)1.80431282
145CNS hypomyelination (HP:0003429)1.79078226
146Upper limb muscle weakness (HP:0003484)1.78509798
147Reticulocytosis (HP:0001923)1.78203813
148Abnormality of pyrimidine metabolism (HP:0004353)1.78023511
149Abnormality of the umbilical cord (HP:0010881)1.77886516
150Death in infancy (HP:0001522)1.77191387
151Sparse eyelashes (HP:0000653)1.76995715
152Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76542707
153Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76542707
154Adenoma sebaceum (HP:0009720)1.76271039
155Angiofibromas (HP:0010615)1.76271039
156Hyperthyroidism (HP:0000836)1.74480776
157Short nail (HP:0001799)1.74349567
158Male infertility (HP:0003251)1.72789742
159Abnormality of alanine metabolism (HP:0010916)1.70021251
160Hyperalaninemia (HP:0003348)1.70021251
161Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70021251
162Hypergonadotropic hypogonadism (HP:0000815)1.68227386
163Gout (HP:0001997)1.64841358
164Atelectasis (HP:0100750)1.64808394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.03744846
2WEE14.46046339
3VRK24.28795988
4CDC73.75257919
5EIF2AK13.24428113
6TSSK62.70390959
7SMG12.70137782
8NEK22.55809111
9PBK2.51351693
10TESK22.45409760
11NEK12.41280282
12TTK2.35300672
13SRPK12.27810211
14PLK42.18532202
15NME22.00757425
16TLK12.00561344
17STK161.99285244
18IRAK31.93160986
19PLK11.89221559
20BRSK21.86118006
21PASK1.80014614
22EIF2AK31.79936290
23RPS6KB21.78245966
24EPHA21.76787591
25VRK11.73293803
26CDK71.73130503
27ACVR1B1.70822147
28EEF2K1.68929592
29ATR1.64011969
30DYRK31.57948504
31MST1R1.56957618
32AURKB1.56483258
33ARAF1.48782326
34MAP3K81.45901833
35TRIB31.39666487
36MKNK11.39217488
37PLK31.38982004
38SCYL21.37133823
39PAK41.36385143
40TESK11.36076771
41CHEK21.35664178
42AURKA1.31419119
43CDK41.31197983
44RPS6KA41.26178375
45BRSK11.26017719
46STK101.25924268
47PIM21.24670058
48MAP3K101.20202360
49CDK121.19958385
50CCNB11.17007333
51FLT31.16267900
52CHEK11.14439358
53KDR1.12910746
54TGFBR11.12304185
55ZAK1.05789395
56MKNK20.96326318
57PKN20.96222000
58CSNK1G30.92336554
59ICK0.90106622
60STK40.89916907
61MAP3K110.89347027
62ABL20.88151032
63LRRK20.84891490
64CDK20.82003071
65PIM10.79834405
66PNCK0.79718110
67MAP4K10.79540664
68ATM0.77525637
69PAK10.77391565
70MAPKAPK30.74755267
71ALK0.71819107
72ERN10.71456684
73CSNK2A20.70991550
74MST40.69555873
75PRKCI0.66866009
76CSNK2A10.66334130
77BRAF0.65225381
78CSNK1A1L0.62776230
79MET0.61636494
80MAP2K70.61443447
81PDK30.60107740
82PDK40.60107740
83CDK80.58583318
84BCKDK0.56405917
85LMTK20.55764728
86CDK10.54545990
87MAPKAPK50.54299200
88CSNK1G10.50623433
89MAP2K30.49371839
90MAP4K20.49108724
91MAPK150.48845411
92EIF2AK20.48639848
93AKT20.46780152
94RAF10.46173286
95MTOR0.46126986
96ILK0.45942406
97CDK11A0.45244451
98MAP3K120.44648846
99CDK60.44369061
100BRD40.44136998
101TAOK20.41979219
102CDK90.41589246
103ZAP700.40334889
104LATS20.40103536
105NME10.40098987
106CDK150.39197607
107RPS6KA50.39124635
108CDK140.39098965
109ERBB40.38792453
110TAF10.37642378
111CAMK2G0.37201086
112LIMK10.36982904
113CSNK1G20.36860587
114CDK180.36689738
115MAPK110.36650404
116CSNK1E0.36621327
117BMX0.34208602
118BTK0.31995502
119MELK0.29372861
120PAK20.27917151
121PRKDC0.27330462
122GRK60.26834063
123DYRK20.26389709
124CLK10.26325804
125BLK0.25245577
126DAPK10.24481296
127PDK20.20121928
128STK30.19781201
129FGFR10.19738873
130TEC0.19302695
131RPS6KA10.19213362
132DAPK30.18425689
133MAPKAPK20.16926380

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.10367537
2Mismatch repair_Homo sapiens_hsa034304.30480362
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.68415010
4Ribosome_Homo sapiens_hsa030103.68307679
5Proteasome_Homo sapiens_hsa030503.50914801
6Spliceosome_Homo sapiens_hsa030403.42225212
7RNA polymerase_Homo sapiens_hsa030203.18639495
8Base excision repair_Homo sapiens_hsa034103.15877446
9RNA transport_Homo sapiens_hsa030133.15587078
10Homologous recombination_Homo sapiens_hsa034402.97457295
11Nucleotide excision repair_Homo sapiens_hsa034202.85755021
12One carbon pool by folate_Homo sapiens_hsa006702.79679021
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.69636211
14Cell cycle_Homo sapiens_hsa041102.57439468
15Pyrimidine metabolism_Homo sapiens_hsa002402.53416239
16Oxidative phosphorylation_Homo sapiens_hsa001902.16650048
17Fanconi anemia pathway_Homo sapiens_hsa034602.07445535
18RNA degradation_Homo sapiens_hsa030181.87205509
19Non-homologous end-joining_Homo sapiens_hsa034501.79820868
20Basal transcription factors_Homo sapiens_hsa030221.72489864
21mRNA surveillance pathway_Homo sapiens_hsa030151.61094501
22p53 signaling pathway_Homo sapiens_hsa041151.50379126
23Purine metabolism_Homo sapiens_hsa002301.35470055
24Alzheimers disease_Homo sapiens_hsa050101.29188977
25Fatty acid elongation_Homo sapiens_hsa000621.25703766
26Epstein-Barr virus infection_Homo sapiens_hsa051691.19364546
27Pentose phosphate pathway_Homo sapiens_hsa000301.17344939
28Biosynthesis of amino acids_Homo sapiens_hsa012301.15543019
29Systemic lupus erythematosus_Homo sapiens_hsa053221.09972599
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.06928417
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06033883
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97381331
33Folate biosynthesis_Homo sapiens_hsa007900.95560625
34Antigen processing and presentation_Homo sapiens_hsa046120.93764298
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92800992
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90513802
37Viral carcinogenesis_Homo sapiens_hsa052030.90300286
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88436091
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.88190226
40Oocyte meiosis_Homo sapiens_hsa041140.86616302
41Selenocompound metabolism_Homo sapiens_hsa004500.86529986
42Sulfur metabolism_Homo sapiens_hsa009200.83179429
43Phenylalanine metabolism_Homo sapiens_hsa003600.82751549
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81593653
45Herpes simplex infection_Homo sapiens_hsa051680.81258638
46Sulfur relay system_Homo sapiens_hsa041220.79163524
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78013130
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76518722
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.75586441
50Carbon metabolism_Homo sapiens_hsa012000.75506839
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72064348
52HTLV-I infection_Homo sapiens_hsa051660.71062466
53Vitamin B6 metabolism_Homo sapiens_hsa007500.70114549
54Fructose and mannose metabolism_Homo sapiens_hsa000510.69670246
55Tyrosine metabolism_Homo sapiens_hsa003500.67564603
56Thyroid cancer_Homo sapiens_hsa052160.65406101
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64834038
58Cardiac muscle contraction_Homo sapiens_hsa042600.61105479
59Steroid biosynthesis_Homo sapiens_hsa001000.59832340
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57221916
61Legionellosis_Homo sapiens_hsa051340.55374559
62Glutathione metabolism_Homo sapiens_hsa004800.53758063
63Huntingtons disease_Homo sapiens_hsa050160.53235693
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52156404
65Galactose metabolism_Homo sapiens_hsa000520.50311063
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49804710
67Small cell lung cancer_Homo sapiens_hsa052220.45783096
68Vibrio cholerae infection_Homo sapiens_hsa051100.45757255
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45701389
70N-Glycan biosynthesis_Homo sapiens_hsa005100.45058974
71MicroRNAs in cancer_Homo sapiens_hsa052060.44861193
72Primary immunodeficiency_Homo sapiens_hsa053400.44268160
73Arginine biosynthesis_Homo sapiens_hsa002200.43749074
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43313897
75Protein export_Homo sapiens_hsa030600.40221365
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.39955468
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39856013
78Apoptosis_Homo sapiens_hsa042100.39389898
79Peroxisome_Homo sapiens_hsa041460.38718866
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38525870
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37869628
82Bladder cancer_Homo sapiens_hsa052190.35786922
83Hippo signaling pathway_Homo sapiens_hsa043900.35435899
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34782789
85HIF-1 signaling pathway_Homo sapiens_hsa040660.34688475
86Propanoate metabolism_Homo sapiens_hsa006400.33398642
87Alcoholism_Homo sapiens_hsa050340.33048218
88Colorectal cancer_Homo sapiens_hsa052100.32752203
89Fatty acid metabolism_Homo sapiens_hsa012120.31754045
90Parkinsons disease_Homo sapiens_hsa050120.30839090
91Notch signaling pathway_Homo sapiens_hsa043300.30502036
92Basal cell carcinoma_Homo sapiens_hsa052170.30304448
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28686619
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28284721
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27560359
96Acute myeloid leukemia_Homo sapiens_hsa052210.26029013
97Shigellosis_Homo sapiens_hsa051310.25590804
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25535892
99TGF-beta signaling pathway_Homo sapiens_hsa043500.25342623
100Lysine degradation_Homo sapiens_hsa003100.22919718
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22850315
102Metabolic pathways_Homo sapiens_hsa011000.22029000
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.21813564
104Measles_Homo sapiens_hsa051620.21702853
105Hepatitis B_Homo sapiens_hsa051610.20984506
106Renin-angiotensin system_Homo sapiens_hsa046140.20443524
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19945095
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19574654
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19120938
110Chronic myeloid leukemia_Homo sapiens_hsa052200.19055497
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18352686
112Pathways in cancer_Homo sapiens_hsa052000.18167340
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17026387
114beta-Alanine metabolism_Homo sapiens_hsa004100.16789928
115Viral myocarditis_Homo sapiens_hsa054160.16619478
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15941926
117mTOR signaling pathway_Homo sapiens_hsa041500.13729012
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13676797
119Hedgehog signaling pathway_Homo sapiens_hsa043400.11233081
120Arginine and proline metabolism_Homo sapiens_hsa003300.10410349
121NF-kappa B signaling pathway_Homo sapiens_hsa040640.09725756
122Influenza A_Homo sapiens_hsa051640.08856608
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08103158
124Butanoate metabolism_Homo sapiens_hsa006500.07306870
125Adherens junction_Homo sapiens_hsa045200.06880612
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.06731655
127Regulation of autophagy_Homo sapiens_hsa041400.06177948
128Asthma_Homo sapiens_hsa053100.04970704
129Pyruvate metabolism_Homo sapiens_hsa006200.04132463
130Tight junction_Homo sapiens_hsa045300.01169211

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