RUNX1T1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.16742189
2presynaptic membrane assembly (GO:0097105)5.15394493
3pyrimidine nucleobase catabolic process (GO:0006208)4.77958624
4postsynaptic membrane organization (GO:0001941)4.69974708
5presynaptic membrane organization (GO:0097090)4.64260182
6positive regulation of synapse assembly (GO:0051965)4.21690918
7vocalization behavior (GO:0071625)3.99735158
8neuron recognition (GO:0008038)3.90398048
9gamma-aminobutyric acid transport (GO:0015812)3.86617028
10regulation of synapse assembly (GO:0051963)3.78484347
11protein localization to synapse (GO:0035418)3.78204458
12sympathetic nervous system development (GO:0048485)3.67770553
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.62409355
14central nervous system projection neuron axonogenesis (GO:0021952)3.62387512
15cerebral cortex radially oriented cell migration (GO:0021799)3.51863974
16limb bud formation (GO:0060174)3.50617450
17chaperone-mediated protein transport (GO:0072321)3.45633190
18axonal fasciculation (GO:0007413)3.39932800
19nucleobase catabolic process (GO:0046113)3.36659049
20facial nerve structural organization (GO:0021612)3.34164838
21dendritic spine morphogenesis (GO:0060997)3.31691148
22regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.26706719
23regulation of respiratory system process (GO:0044065)3.22031617
24righting reflex (GO:0060013)3.21268327
25positive regulation of action potential (GO:0045760)3.21062665
26dendrite development (GO:0016358)3.19233815
27establishment of mitochondrion localization (GO:0051654)3.12683416
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.11736383
29hindbrain development (GO:0030902)3.10631026
30urinary tract smooth muscle contraction (GO:0014848)3.10216445
31mechanosensory behavior (GO:0007638)3.09041700
32glutamate receptor signaling pathway (GO:0007215)3.04202887
33regulation of collateral sprouting (GO:0048670)3.03565727
34protein localization to cilium (GO:0061512)3.02614162
35positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.01330192
36regulation of synapse organization (GO:0050807)2.99653654
37startle response (GO:0001964)2.99142298
38cranial nerve morphogenesis (GO:0021602)2.99090324
39glycosphingolipid biosynthetic process (GO:0006688)2.97778737
40regulation of glutamate receptor signaling pathway (GO:1900449)2.97574359
41synaptic vesicle exocytosis (GO:0016079)2.96687866
42neuronal action potential (GO:0019228)2.95692196
43positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95490529
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.94657730
45central nervous system neuron axonogenesis (GO:0021955)2.93950020
46cell migration in hindbrain (GO:0021535)2.93741603
47neurofilament cytoskeleton organization (GO:0060052)2.93518710
48retinal ganglion cell axon guidance (GO:0031290)2.93405750
49negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92683785
50kidney morphogenesis (GO:0060993)2.91914651
51cranial nerve structural organization (GO:0021604)2.88364763
52intraciliary transport (GO:0042073)2.85321170
53positive regulation of amino acid transport (GO:0051957)2.85091525
54cornea development in camera-type eye (GO:0061303)2.84954096
55membrane depolarization during action potential (GO:0086010)2.84790319
56transmission of nerve impulse (GO:0019226)2.83448255
57response to pheromone (GO:0019236)2.83220694
58regulation of respiratory gaseous exchange (GO:0043576)2.82610299
59negative regulation of axon extension (GO:0030517)2.82550369
60synaptic vesicle maturation (GO:0016188)2.81730623
61positive regulation of dendritic spine morphogenesis (GO:0061003)2.80609085
62negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78660424
63negative regulation of translation, ncRNA-mediated (GO:0040033)2.78660424
64regulation of translation, ncRNA-mediated (GO:0045974)2.78660424
65behavioral response to ethanol (GO:0048149)2.78498385
66negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.77945299
67regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77426075
68regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.77062172
69hippocampus development (GO:0021766)2.76836405
70regulation of short-term neuronal synaptic plasticity (GO:0048172)2.76828526
71neural tube formation (GO:0001841)2.76726449
72negative regulation of dendrite development (GO:2000171)2.76465456
73regulation of synaptic vesicle exocytosis (GO:2000300)2.75260186
74atrial cardiac muscle cell action potential (GO:0086014)2.74859850
75neurotransmitter-gated ion channel clustering (GO:0072578)2.74598165
76synaptic transmission, glutamatergic (GO:0035249)2.72201645
77somite development (GO:0061053)2.71691988
78innervation (GO:0060384)2.68997988
79synapse organization (GO:0050808)2.68649918
80regulation of synapse structural plasticity (GO:0051823)2.68531442
81regulation of action potential (GO:0098900)2.64907991
82regulation of synapse maturation (GO:0090128)2.64214464
83behavioral response to nicotine (GO:0035095)2.63818054
84regulation of dendritic spine morphogenesis (GO:0061001)2.63803290
85opioid receptor signaling pathway (GO:0038003)2.63500321
86adult feeding behavior (GO:0008343)2.62947399
87nonmotile primary cilium assembly (GO:0035058)2.62754150
88microtubule depolymerization (GO:0007019)2.61840904
89synapse assembly (GO:0007416)2.61141519
90auditory behavior (GO:0031223)2.60110580
91epithelial cell differentiation involved in kidney development (GO:0035850)2.59628150
92positive regulation of membrane potential (GO:0045838)2.59288397
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59182735
94regulation of axon guidance (GO:1902667)2.56401964
95regulation of synaptic transmission, glutamatergic (GO:0051966)2.56093338
96head development (GO:0060322)2.54442185
97regulation of synaptic vesicle transport (GO:1902803)2.53836411
98reflex (GO:0060004)2.53422357
99axonogenesis (GO:0007409)2.52713422
100neuron-neuron synaptic transmission (GO:0007270)2.52499671
101regulation of pigment cell differentiation (GO:0050932)2.52453959
102adult walking behavior (GO:0007628)2.52277984
103adult behavior (GO:0030534)2.51564912
104protein neddylation (GO:0045116)2.51082578
105spinal cord development (GO:0021510)2.50774950
106response to auditory stimulus (GO:0010996)2.50642327
107G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50480949
108generation of neurons (GO:0048699)2.49787001
109regulation of non-canonical Wnt signaling pathway (GO:2000050)2.49602691
110positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.47629262
111substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.46959992
112substrate-independent telencephalic tangential migration (GO:0021826)2.46959992
113regulation of telomere maintenance (GO:0032204)2.46714568
114exploration behavior (GO:0035640)2.45894966
115axon extension (GO:0048675)2.45706150
116regulation of feeding behavior (GO:0060259)2.45031502
117neurotransmitter secretion (GO:0007269)2.43907829
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.43116910
119cardiac ventricle formation (GO:0003211)2.42360825
120tachykinin receptor signaling pathway (GO:0007217)2.42177477
121negative regulation of axonogenesis (GO:0050771)2.41629188
122regulation of male gonad development (GO:2000018)2.41610451
123cerebral cortex cell migration (GO:0021795)2.41337181
124action potential (GO:0001508)2.40962335
125cardiac chamber formation (GO:0003207)2.40207912
126regulation of dendritic spine development (GO:0060998)2.40050791
127gamma-aminobutyric acid signaling pathway (GO:0007214)2.39995631
128dendrite morphogenesis (GO:0048813)2.39591477
129regulation of synaptic transmission, GABAergic (GO:0032228)2.39028798
130cell differentiation involved in kidney development (GO:0061005)2.37619780
131calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.37527542
132regulation of excitatory postsynaptic membrane potential (GO:0060079)2.36978553
133cerebellum development (GO:0021549)2.34085173
134mesenchymal cell differentiation involved in kidney development (GO:0072161)2.33782855
135mesenchymal cell differentiation involved in renal system development (GO:2001012)2.33782855
136neuron migration (GO:0001764)2.33749773
137regulation of timing of cell differentiation (GO:0048505)2.33151584
138neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.32373094
139regulation of postsynaptic membrane potential (GO:0060078)2.31106208
140forebrain neuron development (GO:0021884)2.30635260
141cullin deneddylation (GO:0010388)2.29200563
142negative regulation of axon guidance (GO:1902668)2.28975169
143negative regulation of synaptic transmission, GABAergic (GO:0032229)2.28468177
144cardiac right ventricle morphogenesis (GO:0003215)2.28124802
145protein complex biogenesis (GO:0070271)2.27456830
146positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.27145189
147neuronal action potential propagation (GO:0019227)2.26459055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.77298665
2GBX2_23144817_ChIP-Seq_PC3_Human4.07717539
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74814702
4* EZH2_27304074_Chip-Seq_ESCs_Mouse2.71983735
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70464227
6* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.59556047
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.53715325
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46444019
9* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45826268
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.38730672
11TAF15_26573619_Chip-Seq_HEK293_Human2.33343513
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33204566
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28772007
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25542131
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20493857
16PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.20244160
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19985603
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19985603
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19086068
20* RNF2_27304074_Chip-Seq_NSC_Mouse2.15796630
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14769110
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.14585935
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11862906
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05084647
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04636070
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00764189
27* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98505615
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97240180
29* P300_19829295_ChIP-Seq_ESCs_Human1.95182424
30* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94067958
31IGF1R_20145208_ChIP-Seq_DFB_Human1.93072368
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91262732
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.90885037
34REST_21632747_ChIP-Seq_MESCs_Mouse1.88461517
35* RNF2_27304074_Chip-Seq_ESCs_Mouse1.87057308
36* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86150277
37VDR_22108803_ChIP-Seq_LS180_Human1.83720896
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82571748
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.81713028
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81331029
41FUS_26573619_Chip-Seq_HEK293_Human1.79321624
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.75779994
43* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69385799
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65211121
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64619664
46* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61546200
47SMAD4_21799915_ChIP-Seq_A2780_Human1.58274609
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53112428
49CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52644967
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.52358041
51* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52285644
52ZNF274_21170338_ChIP-Seq_K562_Hela1.52135536
53AR_21572438_ChIP-Seq_LNCaP_Human1.41428867
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39812034
55CBP_20019798_ChIP-Seq_JUKART_Human1.39812034
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.39684972
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39373604
58* SMAD3_21741376_ChIP-Seq_EPCs_Human1.38353416
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38126949
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37684614
61BCAT_22108803_ChIP-Seq_LS180_Human1.33473944
62* NANOG_18555785_Chip-Seq_ESCs_Mouse1.30495655
63ER_23166858_ChIP-Seq_MCF-7_Human1.30478567
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.30016727
65* EWS_26573619_Chip-Seq_HEK293_Human1.27684666
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27208462
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26948074
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26948074
69* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26881127
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24104504
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22869650
72* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22508226
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22190487
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21910255
75* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21476863
76RUNX2_22187159_ChIP-Seq_PCA_Human1.20906955
77DROSHA_22980978_ChIP-Seq_HELA_Human1.19381611
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15103956
79* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12991379
80* AR_25329375_ChIP-Seq_VCAP_Human1.12659785
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.11054745
82* P53_22387025_ChIP-Seq_ESCs_Mouse1.10701648
83* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10235746
84* E2F1_18555785_Chip-Seq_ESCs_Mouse1.09707999
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.09135684
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08350525
87STAT3_23295773_ChIP-Seq_U87_Human1.08147798
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07922426
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07812840
90TCF4_22108803_ChIP-Seq_LS180_Human1.06966209
91TP53_18474530_ChIP-ChIP_U2OS_Human1.06205370
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06166132
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06019478
94JUN_21703547_ChIP-Seq_K562_Human1.05708513
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05110605
96* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04639681
97TCF4_23295773_ChIP-Seq_U87_Human1.04316983
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03878681
99* CMYC_18555785_Chip-Seq_ESCs_Mouse1.01744425
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00848799
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00172235
102* KDM2B_26808549_Chip-Seq_REH_Human0.99726851
103* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99466169
104* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99026990
105* SOX9_26525672_Chip-Seq_HEART_Mouse0.98711127
106* TAL1_26923725_Chip-Seq_HPCs_Mouse0.98315782
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.97404015
108SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97052946
109TP53_20018659_ChIP-ChIP_R1E_Mouse0.96472383
110* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96236803
111* SOX2_21211035_ChIP-Seq_LN229_Gbm0.96190271
112NMYC_18555785_Chip-Seq_ESCs_Mouse0.95460503
113YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94775204
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94497945
115* STAT3_18555785_Chip-Seq_ESCs_Mouse0.94469865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.40227887
2MP0001188_hyperpigmentation3.60060000
3MP0006292_abnormal_olfactory_placode3.37602169
4MP0006276_abnormal_autonomic_nervous3.34611703
5MP0003122_maternal_imprinting2.99777028
6MP0002638_abnormal_pupillary_reflex2.52223338
7MP0004270_analgesia2.33326058
8MP0001529_abnormal_vocalization2.33087128
9MP0000569_abnormal_digit_pigmentation2.29506962
10MP0000778_abnormal_nervous_system2.27145787
11MP0005423_abnormal_somatic_nervous2.20966129
12MP0003635_abnormal_synaptic_transmissio2.16206507
13MP0002184_abnormal_innervation2.15325306
14MP0001984_abnormal_olfaction2.08877563
15MP0008877_abnormal_DNA_methylation2.06844035
16MP0002734_abnormal_mechanical_nocicepti2.04928094
17MP0001968_abnormal_touch/_nociception2.03516277
18MP0002938_white_spotting1.99165956
19MP0004859_abnormal_synaptic_plasticity1.97913370
20MP0002063_abnormal_learning/memory/cond1.97271168
21MP0008789_abnormal_olfactory_epithelium1.97216281
22MP0003787_abnormal_imprinting1.95829383
23MP0003121_genomic_imprinting1.92445996
24MP0005645_abnormal_hypothalamus_physiol1.92323179
25MP0002102_abnormal_ear_morphology1.90639692
26MP0000566_synostosis1.87257968
27MP0010386_abnormal_urinary_bladder1.86615614
28MP0002572_abnormal_emotion/affect_behav1.82567338
29MP0002735_abnormal_chemical_nociception1.77937368
30MP0005499_abnormal_olfactory_system1.76364661
31MP0005394_taste/olfaction_phenotype1.76364661
32MP0002822_catalepsy1.75982859
33MP0001486_abnormal_startle_reflex1.75345129
34MP0005187_abnormal_penis_morphology1.71572058
35MP0009745_abnormal_behavioral_response1.70090722
36MP0005409_darkened_coat_color1.66411480
37MP0000631_abnormal_neuroendocrine_gland1.66268529
38MP0002557_abnormal_social/conspecific_i1.66052250
39MP0002751_abnormal_autonomic_nervous1.65301013
40MP0003195_calcinosis1.61590045
41MP0002272_abnormal_nervous_system1.55366972
42MP0001502_abnormal_circadian_rhythm1.53817605
43MP0002736_abnormal_nociception_after1.53278896
44MP0009379_abnormal_foot_pigmentation1.51937045
45MP0004885_abnormal_endolymph1.49707358
46MP0002067_abnormal_sensory_capabilities1.49019703
47MP0005646_abnormal_pituitary_gland1.42761141
48MP0005367_renal/urinary_system_phenotyp1.39361887
49MP0000516_abnormal_urinary_system1.39361887
50MP0002064_seizures1.37213118
51MP0006072_abnormal_retinal_apoptosis1.35630743
52MP0001986_abnormal_taste_sensitivity1.35224160
53MP0000049_abnormal_middle_ear1.29965119
54MP0009046_muscle_twitch1.29392311
55MP0001970_abnormal_pain_threshold1.29055701
56MP0002909_abnormal_adrenal_gland1.27472772
57MP0000015_abnormal_ear_pigmentation1.23459200
58MP0002234_abnormal_pharynx_morphology1.22609894
59MP0002733_abnormal_thermal_nociception1.20492310
60MP0004742_abnormal_vestibular_system1.14781773
61MP0003938_abnormal_ear_development1.14259780
62MP0005248_abnormal_Harderian_gland1.13691302
63MP0002882_abnormal_neuron_morphology1.13184493
64MP0004145_abnormal_muscle_electrophysio1.12730102
65MP0002177_abnormal_outer_ear1.12670459
66MP0000026_abnormal_inner_ear1.12211272
67* MP0003385_abnormal_body_wall1.12028003
68MP0001905_abnormal_dopamine_level1.11868539
69MP0000955_abnormal_spinal_cord1.11043234
70MP0004811_abnormal_neuron_physiology1.09537282
71MP0005551_abnormal_eye_electrophysiolog1.09197093
72MP0005386_behavior/neurological_phenoty1.08667082
73MP0004924_abnormal_behavior1.08667082
74MP0002876_abnormal_thyroid_physiology1.07877842
75MP0009250_abnormal_appendicular_skeleto1.06767017
76MP0005257_abnormal_intraocular_pressure1.06164766
77* MP0003119_abnormal_digestive_system1.04092124
78MP0004142_abnormal_muscle_tone1.03544831
79MP0002752_abnormal_somatic_nervous1.03087274
80MP0003136_yellow_coat_color1.03049714
81MP0003567_abnormal_fetal_cardiomyocyte0.99775594
82MP0002152_abnormal_brain_morphology0.99235529
83MP0003283_abnormal_digestive_organ0.98995189
84MP0001440_abnormal_grooming_behavior0.96338035
85MP0003942_abnormal_urinary_system0.95546910
86MP0005171_absent_coat_pigmentation0.94460073
87MP0003861_abnormal_nervous_system0.92441990
88MP0003937_abnormal_limbs/digits/tail_de0.91800636
89MP0003315_abnormal_perineum_morphology0.91752917
90MP0001963_abnormal_hearing_physiology0.90505455
91MP0003137_abnormal_impulse_conducting0.88792653
92MP0003755_abnormal_palate_morphology0.88669419
93MP0003633_abnormal_nervous_system0.87842585
94MP0001177_atelectasis0.87227062
95MP0004215_abnormal_myocardial_fiber0.87084412
96MP0001299_abnormal_eye_distance/0.85782267
97MP0003879_abnormal_hair_cell0.85552918
98MP0000372_irregular_coat_pigmentation0.85451324
99MP0004085_abnormal_heartbeat0.85318878
100MP0003890_abnormal_embryonic-extraembry0.85289032
101MP0004043_abnormal_pH_regulation0.84557765
102MP0002066_abnormal_motor_capabilities/c0.83278953
103MP0008569_lethality_at_weaning0.83134698
104* MP0002069_abnormal_eating/drinking_beha0.82863507
105MP0000647_abnormal_sebaceous_gland0.82481018
106MP0001501_abnormal_sleep_pattern0.81964176
107MP0005195_abnormal_posterior_eye0.79848900
108MP0005253_abnormal_eye_physiology0.79673192
109MP0002116_abnormal_craniofacial_bone0.79382229
110MP0002163_abnormal_gland_morphology0.78260214
111MP0010030_abnormal_orbit_morphology0.77609081
112MP0002233_abnormal_nose_morphology0.77355162
113MP0002229_neurodegeneration0.77072298
114MP0002837_dystrophic_cardiac_calcinosis0.77062787
115MP0005379_endocrine/exocrine_gland_phen0.74824348
116MP0005084_abnormal_gallbladder_morpholo0.74339778
117MP0004133_heterotaxia0.73571793
118MP0005503_abnormal_tendon_morphology0.73167802
119MP0009697_abnormal_copulation0.72864038
120MP0001485_abnormal_pinna_reflex0.72328984
121MP0002928_abnormal_bile_duct0.72080866
122MP0001346_abnormal_lacrimal_gland0.72055838
123MP0000534_abnormal_ureter_morphology0.71896656
124MP0001286_abnormal_eye_development0.71572130
125MP0000538_abnormal_urinary_bladder0.70324460
126MP0000681_abnormal_thyroid_gland0.69590339
127MP0003935_abnormal_craniofacial_develop0.69558133

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)4.07467462
2Focal motor seizures (HP:0011153)3.62535582
3Febrile seizures (HP:0002373)3.61234836
4Gait imbalance (HP:0002141)3.28341467
5Protruding tongue (HP:0010808)3.13384532
6Medial flaring of the eyebrow (HP:0010747)3.10170450
7Absent eyebrow (HP:0002223)3.09256873
8Hypothermia (HP:0002045)3.01302096
9Congenital primary aphakia (HP:0007707)2.86761770
10Morphological abnormality of the middle ear (HP:0008609)2.84377344
11True hermaphroditism (HP:0010459)2.82206526
12Nephrogenic diabetes insipidus (HP:0009806)2.79215672
13Epileptic encephalopathy (HP:0200134)2.72844052
14Midline defect of the nose (HP:0004122)2.72066726
15Limb dystonia (HP:0002451)2.71715282
16Failure to thrive in infancy (HP:0001531)2.65875938
17Gaze-evoked nystagmus (HP:0000640)2.59866136
18Hypsarrhythmia (HP:0002521)2.58031662
19Vaginal atresia (HP:0000148)2.57535663
20Genital tract atresia (HP:0001827)2.56110092
21Inability to walk (HP:0002540)2.55679926
22Polyphagia (HP:0002591)2.54927291
23Pachygyria (HP:0001302)2.50518712
24Genetic anticipation (HP:0003743)2.50508986
25Hyperventilation (HP:0002883)2.46000731
26Aplasia/Hypoplasia of the lens (HP:0008063)2.44624932
27Bifid tongue (HP:0010297)2.43855716
28Hemiparesis (HP:0001269)2.43355271
29Generalized tonic-clonic seizures (HP:0002069)2.43114799
30Sleep apnea (HP:0010535)2.42065008
31Volvulus (HP:0002580)2.41279161
32Atonic seizures (HP:0010819)2.39637962
33Broad-based gait (HP:0002136)2.38449900
34Progressive cerebellar ataxia (HP:0002073)2.38392787
35Acute necrotizing encephalopathy (HP:0006965)2.36115364
36Esotropia (HP:0000565)2.35632474
37Progressive inability to walk (HP:0002505)2.34209074
38Focal seizures (HP:0007359)2.33753418
39Lissencephaly (HP:0001339)2.30223512
40Abnormality of the renal medulla (HP:0100957)2.27506632
41Pancreatic fibrosis (HP:0100732)2.25903731
42Poor coordination (HP:0002370)2.22705486
43Abnormality of the nasolacrimal system (HP:0000614)2.17264504
44Myokymia (HP:0002411)2.17107398
45Abnormality of the lacrimal duct (HP:0011481)2.15511194
46Action tremor (HP:0002345)2.14449846
47Abnormality of the labia minora (HP:0012880)2.10378263
48Progressive macrocephaly (HP:0004481)2.10376214
49Retinal dysplasia (HP:0007973)2.09617422
50Congenital stationary night blindness (HP:0007642)2.08867359
51Scrotal hypoplasia (HP:0000046)2.08347157
52Ulnar claw (HP:0001178)2.07764441
53Amblyopia (HP:0000646)2.07501076
54Inappropriate behavior (HP:0000719)2.06383036
55Severe visual impairment (HP:0001141)2.05652131
56Narrow nasal bridge (HP:0000446)2.05490972
57Slow-growing hair (HP:0002217)2.04710892
58Abnormality of hair growth rate (HP:0011363)2.04710892
59Cutaneous finger syndactyly (HP:0010554)2.04597239
60Absent speech (HP:0001344)2.04277613
61Agitation (HP:0000713)2.03120156
62Molar tooth sign on MRI (HP:0002419)2.02852957
63Abnormality of midbrain morphology (HP:0002418)2.02852957
64Abnormality of the phalanges of the hallux (HP:0010057)2.02849189
65Optic nerve hypoplasia (HP:0000609)2.02358164
66Aplasia/Hypoplasia of the fovea (HP:0008060)2.01287534
67Hypoplasia of the fovea (HP:0007750)2.01287534
68Shawl scrotum (HP:0000049)1.99459566
69Hepatoblastoma (HP:0002884)1.98882845
70Pancreatic cysts (HP:0001737)1.98616982
71Abnormality of the astrocytes (HP:0100707)1.98292412
72Astrocytoma (HP:0009592)1.98292412
73Poor suck (HP:0002033)1.97321078
74Type II lissencephaly (HP:0007260)1.96993928
75Narrow forehead (HP:0000341)1.96711974
76Specific learning disability (HP:0001328)1.96046466
77Methylmalonic acidemia (HP:0002912)1.95929123
78Abnormal mitochondria in muscle tissue (HP:0008316)1.95824272
79Amyotrophic lateral sclerosis (HP:0007354)1.95090364
80Chronic hepatic failure (HP:0100626)1.94375952
81Poor eye contact (HP:0000817)1.93426991
82Abnormality of salivation (HP:0100755)1.92745572
83Absent eyelashes (HP:0000561)1.91867497
84Abnormality of incisor morphology (HP:0011063)1.91745689
85Abnormality of the aortic arch (HP:0012303)1.91330786
86Spastic tetraplegia (HP:0002510)1.89744983
87Neoplasm of the adrenal cortex (HP:0100641)1.89529357
88Abnormality of the corticospinal tract (HP:0002492)1.88974733
89Patellar aplasia (HP:0006443)1.87306076
90Excessive salivation (HP:0003781)1.86713506
91Drooling (HP:0002307)1.86713506
92Aplasia/Hypoplasia of the tibia (HP:0005772)1.84979930
93Urinary urgency (HP:0000012)1.84530934
94Optic disc pallor (HP:0000543)1.83672483
95Anencephaly (HP:0002323)1.82262939
96Absence seizures (HP:0002121)1.82154528
97Myelomeningocele (HP:0002475)1.81769591
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81425869
99Impaired social interactions (HP:0000735)1.81258073
100Abnormal social behavior (HP:0012433)1.81258073
101Absent hair (HP:0002298)1.81168225
102Widely spaced teeth (HP:0000687)1.79533280
103Tented upper lip vermilion (HP:0010804)1.79028283
104Labial hypoplasia (HP:0000066)1.76978746
105Prolonged QT interval (HP:0001657)1.76374951
106Abnormality of the renal cortex (HP:0011035)1.76141499
107Short foot (HP:0001773)1.76070398
108Mitochondrial inheritance (HP:0001427)1.76025665
109Hypoplasia of the brainstem (HP:0002365)1.75730386
110Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75730386
111Renal hypoplasia (HP:0000089)1.75624043
112Epileptiform EEG discharges (HP:0011182)1.75352332
113Oligodactyly (hands) (HP:0001180)1.75236745
114Adrenal hypoplasia (HP:0000835)1.74962004
115Generalized myoclonic seizures (HP:0002123)1.74638699
116Short tibia (HP:0005736)1.74313729
117Dysdiadochokinesis (HP:0002075)1.73257930
118Aplasia/Hypoplasia of the patella (HP:0006498)1.73024449
119Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.72842767
120Micropenis (HP:0000054)1.72379475
121Renal cortical cysts (HP:0000803)1.72215629
122Fair hair (HP:0002286)1.71928340
123Atelectasis (HP:0100750)1.71765778
124Atrioventricular canal defect (HP:0006695)1.71619990
125Nephronophthisis (HP:0000090)1.71414881
126Growth hormone deficiency (HP:0000824)1.70605276
127Intestinal atresia (HP:0011100)1.70539822
128Cutaneous syndactyly (HP:0012725)1.70180822
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.69521812
130Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69521812
131Aganglionic megacolon (HP:0002251)1.69289382
132Macroglossia (HP:0000158)1.68804788
133Dynein arm defect of respiratory motile cilia (HP:0012255)1.68451048
134Absent/shortened dynein arms (HP:0200106)1.68451048
135Preaxial hand polydactyly (HP:0001177)1.68374933
136Postaxial hand polydactyly (HP:0001162)1.67544807
137Abnormality of the metopic suture (HP:0005556)1.67235693
138Abnormal eating behavior (HP:0100738)1.66996392
139Heterochromia iridis (HP:0001100)1.66392869
140Type I transferrin isoform profile (HP:0003642)1.66373240
141Dialeptic seizures (HP:0011146)1.65493287
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.64465307
143EEG with generalized epileptiform discharges (HP:0011198)1.63944691
144Abnormality of the fovea (HP:0000493)1.63906512
145Exotropia (HP:0000577)1.63364202
146Bulbous nose (HP:0000414)1.63086098
147Anophthalmia (HP:0000528)1.62856286
148Blue irides (HP:0000635)1.62333745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.14580742
2MARK14.04160788
3FRK3.88663706
4AKT33.59790959
5MAPK132.98849470
6TNIK2.84871354
7MAP2K72.74037340
8DYRK22.60515809
9MAP4K22.32000846
10SIK32.06794188
11WNK32.06747653
12ERBB31.99270951
13MUSK1.98225662
14BMPR1B1.96384091
15TRIM281.90404510
16NTRK21.90235078
17NTRK31.90095059
18MAP3K121.85997782
19SGK21.73953779
20MKNK21.73815038
21YES11.69128244
22PINK11.67740835
23UHMK11.64264793
24SRPK11.59782673
25BRAF1.54139595
26LIMK11.52035865
27MAP3K41.50516707
28PRPF4B1.46476182
29SGK2231.42613455
30SGK4941.42613455
31SIK21.40652982
32EPHA41.29551599
33MKNK11.26451776
34BMPR21.22867918
35MINK11.22577767
36DYRK1A1.22432156
37STK161.19332406
38BCR1.17928740
39FGFR21.15320467
40ZAK1.13915897
41PLK21.12747353
42GRK11.08431954
43OBSCN1.06878733
44VRK11.06649378
45EPHB21.04974277
46KSR11.04404752
47CDK190.99778634
48INSRR0.96529817
49MYLK0.94975590
50PNCK0.91599696
51CDK30.86025852
52GRK70.85709661
53ADRBK20.85393342
54EIF2AK20.81073524
55NME10.80559215
56CAMK2A0.80407050
57ACVR1B0.76842309
58NUAK10.75899822
59CDK80.74824269
60CDK50.74445941
61PRKCG0.71812337
62IRAK20.70273494
63DYRK30.68851422
64SGK30.67705741
65CAMK40.66834685
66CAMK2B0.65898639
67PRKCE0.65313354
68PAK60.64350549
69CSNK1G20.62791605
70CSNK1G30.62676120
71ADRBK10.62573075
72MAP2K40.61163681
73PHKG20.61144743
74PHKG10.61144743
75CDC42BPA0.60366147
76OXSR10.57974987
77PLK30.56398406
78EPHA30.54435527
79TAOK10.54029729
80CAMKK20.53333895
81CAMK10.53083853
82GRK50.52374199
83PRKG10.51777778
84CSNK1G10.50878620
85CSNK1D0.49746255
86ROCK10.49368515
87CAMK1G0.48655222
88RPS6KA40.48359657
89CSNK1A1L0.48254312
90RPS6KB10.47652069
91FER0.47421707
92DAPK10.47093162
93CSNK1E0.47075908
94PAK30.46120723
95CCNB10.45785347
96CSNK1A10.45533519
97MAPK150.44959170
98TIE10.44548227
99PRKACA0.42803880
100FES0.42414184
101STK110.42190373
102RPS6KA20.41527541
103DAPK20.41267487
104PRKACB0.40177920
105CDK180.40054049
106SGK10.39775119
107TNK20.39379824
108NEK60.39205968
109NEK10.38684705
110STK38L0.38319962
111MARK20.38187353
112PKN10.36800154
113MAPK40.35664938
114NTRK10.34624232
115PRKCZ0.33879245
116CDK140.33845998
117STK390.33693363
118HIPK20.33585602
119IRAK10.33298786
120CAMK2D0.32753161
121MAPK90.32485304
122EIF2AK30.30638062
123MAP3K60.30504600
124WNK40.30400199
125STK240.30205245
126RPS6KA30.29723224
127BRD40.28985729
128CDK150.28533161
129PLK40.27365836
130PRKCB0.27318133
131MAPK80.26457140

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.07678090
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35258448
3Oxidative phosphorylation_Homo sapiens_hsa001902.23827750
4Morphine addiction_Homo sapiens_hsa050322.11710056
5Taste transduction_Homo sapiens_hsa047422.09828098
6Serotonergic synapse_Homo sapiens_hsa047262.06620654
7Synaptic vesicle cycle_Homo sapiens_hsa047212.03459121
8Circadian entrainment_Homo sapiens_hsa047132.03296679
9GABAergic synapse_Homo sapiens_hsa047271.99747341
10Glutamatergic synapse_Homo sapiens_hsa047241.95822027
11Parkinsons disease_Homo sapiens_hsa050121.83242874
12Olfactory transduction_Homo sapiens_hsa047401.80843050
13Axon guidance_Homo sapiens_hsa043601.79994551
14Cardiac muscle contraction_Homo sapiens_hsa042601.79064705
15Phototransduction_Homo sapiens_hsa047441.78112049
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75697282
17Amphetamine addiction_Homo sapiens_hsa050311.71439420
18Dopaminergic synapse_Homo sapiens_hsa047281.71016967
19Huntingtons disease_Homo sapiens_hsa050161.69307729
20Alzheimers disease_Homo sapiens_hsa050101.68866404
21Butanoate metabolism_Homo sapiens_hsa006501.68423977
22Long-term depression_Homo sapiens_hsa047301.67764036
23Insulin secretion_Homo sapiens_hsa049111.67081823
24Long-term potentiation_Homo sapiens_hsa047201.59860279
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54521777
26Cocaine addiction_Homo sapiens_hsa050301.47177349
27Cholinergic synapse_Homo sapiens_hsa047251.41299815
28Protein export_Homo sapiens_hsa030601.40164401
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.36799114
30Collecting duct acid secretion_Homo sapiens_hsa049661.35463755
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.32402614
32Wnt signaling pathway_Homo sapiens_hsa043101.29724755
33Basal transcription factors_Homo sapiens_hsa030221.29313093
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24761546
35Circadian rhythm_Homo sapiens_hsa047101.22640168
36Hedgehog signaling pathway_Homo sapiens_hsa043401.16048784
37Renin secretion_Homo sapiens_hsa049241.13884891
38Calcium signaling pathway_Homo sapiens_hsa040201.12302531
39Melanogenesis_Homo sapiens_hsa049161.09270623
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08927646
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07539898
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07400746
43Basal cell carcinoma_Homo sapiens_hsa052171.07139408
44Steroid biosynthesis_Homo sapiens_hsa001001.06286054
45Ether lipid metabolism_Homo sapiens_hsa005651.05014755
46Oxytocin signaling pathway_Homo sapiens_hsa049211.03363868
47Vibrio cholerae infection_Homo sapiens_hsa051101.03256500
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02431861
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01180655
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00837758
51Gap junction_Homo sapiens_hsa045400.99276711
52Dorso-ventral axis formation_Homo sapiens_hsa043200.97347136
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95713679
54Selenocompound metabolism_Homo sapiens_hsa004500.93398395
55ErbB signaling pathway_Homo sapiens_hsa040120.92894351
56Linoleic acid metabolism_Homo sapiens_hsa005910.90954741
57cAMP signaling pathway_Homo sapiens_hsa040240.90462790
58RNA polymerase_Homo sapiens_hsa030200.89649254
59Propanoate metabolism_Homo sapiens_hsa006400.88673951
60Alcoholism_Homo sapiens_hsa050340.87631192
61Fanconi anemia pathway_Homo sapiens_hsa034600.86396121
62Salivary secretion_Homo sapiens_hsa049700.84893480
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84512718
64N-Glycan biosynthesis_Homo sapiens_hsa005100.83923326
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82052548
66Regulation of autophagy_Homo sapiens_hsa041400.81845111
67Dilated cardiomyopathy_Homo sapiens_hsa054140.80975611
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80238776
69Endometrial cancer_Homo sapiens_hsa052130.80089063
70Proteasome_Homo sapiens_hsa030500.79702965
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78190097
72Colorectal cancer_Homo sapiens_hsa052100.76757706
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75971459
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74763800
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72944915
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72034726
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.71996470
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71119487
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68567556
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68184563
81RNA degradation_Homo sapiens_hsa030180.67404309
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67008861
83Tryptophan metabolism_Homo sapiens_hsa003800.66634905
84GnRH signaling pathway_Homo sapiens_hsa049120.64914027
85Melanoma_Homo sapiens_hsa052180.63026445
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62941492
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58313889
88MAPK signaling pathway_Homo sapiens_hsa040100.58141293
89Spliceosome_Homo sapiens_hsa030400.57985898
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57303234
91Tight junction_Homo sapiens_hsa045300.55474167
92Ovarian steroidogenesis_Homo sapiens_hsa049130.54338797
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53564876
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53502669
95Ras signaling pathway_Homo sapiens_hsa040140.53218983
96Gastric acid secretion_Homo sapiens_hsa049710.52726820
97mRNA surveillance pathway_Homo sapiens_hsa030150.52578349
98Phagosome_Homo sapiens_hsa041450.50934706
99Purine metabolism_Homo sapiens_hsa002300.50125069
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49722374
101Nitrogen metabolism_Homo sapiens_hsa009100.49643760
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48909460
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48732547
104TGF-beta signaling pathway_Homo sapiens_hsa043500.47527575
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47182980
106Oocyte meiosis_Homo sapiens_hsa041140.46912780
107Type II diabetes mellitus_Homo sapiens_hsa049300.45024603
108Peroxisome_Homo sapiens_hsa041460.44087410
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43860552
110Autoimmune thyroid disease_Homo sapiens_hsa053200.43690165
111Hippo signaling pathway_Homo sapiens_hsa043900.43357310
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41422043
113Renal cell carcinoma_Homo sapiens_hsa052110.39316806
114ABC transporters_Homo sapiens_hsa020100.39132176
115Arachidonic acid metabolism_Homo sapiens_hsa005900.38920612
116Rap1 signaling pathway_Homo sapiens_hsa040150.37894045
117Glioma_Homo sapiens_hsa052140.37100904
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36228288
119Estrogen signaling pathway_Homo sapiens_hsa049150.35702485
120Type I diabetes mellitus_Homo sapiens_hsa049400.35350569
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35107636
122Choline metabolism in cancer_Homo sapiens_hsa052310.35093989
123Caffeine metabolism_Homo sapiens_hsa002320.34700229
124Thyroid cancer_Homo sapiens_hsa052160.34498828
125Fatty acid elongation_Homo sapiens_hsa000620.34498484
126AMPK signaling pathway_Homo sapiens_hsa041520.32924451
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.32123396

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