RUFY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a RUN domain and a FYVE-type zinc finger domain. The encoded protein binds to phosphatidylinositol-3-phosphate (PI3P) and plays a role in early endosomal trafficking, tethering and fusion through interactions with small GTPases including Rab4, Rab5 and Rab14. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.82979758
2neutrophil activation involved in immune response (GO:0002283)7.49338957
3transcription from mitochondrial promoter (GO:0006390)7.03925065
4proline metabolic process (GO:0006560)6.90075175
5fat-soluble vitamin biosynthetic process (GO:0042362)6.34452616
6thrombin receptor signaling pathway (GO:0070493)6.24038931
7embryonic process involved in female pregnancy (GO:0060136)6.19333184
8regulation of protein homooligomerization (GO:0032462)5.79173330
9regulation of integrin activation (GO:0033623)5.77471422
10positive regulation of protein homooligomerization (GO:0032464)5.55814186
11response to pheromone (GO:0019236)5.50291607
12regulation of platelet aggregation (GO:0090330)5.40926077
13adenosine receptor signaling pathway (GO:0001973)5.33392135
14positive regulation of dendritic spine morphogenesis (GO:0061003)5.18442377
15regulation of platelet activation (GO:0010543)5.12470957
16oxidative demethylation (GO:0070989)5.08939194
17cellular response to zinc ion (GO:0071294)4.98220839
18replication fork processing (GO:0031297)4.94196021
19negative regulation of protein oligomerization (GO:0032460)4.84203760
20positive regulation of mast cell activation (GO:0033005)4.82780207
21leukocyte migration involved in inflammatory response (GO:0002523)4.79292638
22platelet aggregation (GO:0070527)4.67656491
23protein neddylation (GO:0045116)4.61711750
24cellular response to ATP (GO:0071318)4.61104727
25neutrophil activation (GO:0042119)4.60552157
26G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.53130308
27protein localization to endosome (GO:0036010)4.49312319
28negative regulation of fatty acid biosynthetic process (GO:0045717)4.34987984
29angiogenesis involved in wound healing (GO:0060055)4.30126634
30negative regulation of homotypic cell-cell adhesion (GO:0034111)4.29169672
31blood coagulation, intrinsic pathway (GO:0007597)4.28065791
32granulocyte activation (GO:0036230)4.21734452
33lipoxygenase pathway (GO:0019372)4.18236952
34embryonic placenta development (GO:0001892)4.17777850
35glutamine family amino acid biosynthetic process (GO:0009084)4.09527200
36mitochondrial DNA metabolic process (GO:0032042)4.05648460
37negative regulation of platelet activation (GO:0010544)3.99860345
38purinergic nucleotide receptor signaling pathway (GO:0035590)3.97416861
39intestinal cholesterol absorption (GO:0030299)3.96117718
40sulfur amino acid catabolic process (GO:0000098)3.93503466
41positive regulation of macrophage differentiation (GO:0045651)3.91569803
42regulation of integrin-mediated signaling pathway (GO:2001044)3.88925845
43negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.88875641
44triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.88283010
45establishment of apical/basal cell polarity (GO:0035089)3.85184554
46negative regulation of thymocyte apoptotic process (GO:0070244)3.76957096
47regulation of mast cell degranulation (GO:0043304)3.75123400
48G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.70291456
49GDP-mannose metabolic process (GO:0019673)3.69154850
50positive regulation of endothelial cell differentiation (GO:0045603)3.67457777
51maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.64587533
52regulation of protein oligomerization (GO:0032459)3.63866237
53megakaryocyte development (GO:0035855)3.62645873
54regulation of podosome assembly (GO:0071801)3.61569411
55negative regulation of JAK-STAT cascade (GO:0046426)3.59708012
56regulation of mast cell activation (GO:0033003)3.59341562
57purinergic receptor signaling pathway (GO:0035587)3.56119321
58regulation of mast cell activation involved in immune response (GO:0033006)3.52956690
59positive regulation by host of viral transcription (GO:0043923)3.50530568
60negative regulation of norepinephrine secretion (GO:0010700)3.50107371
61membrane tubulation (GO:0097320)3.47273725
62regulation of MHC class II biosynthetic process (GO:0045346)3.47213070
63negative regulation of erythrocyte differentiation (GO:0045647)3.43594363
64mitotic G1 DNA damage checkpoint (GO:0031571)3.41477844
65positive regulation of mast cell activation involved in immune response (GO:0033008)3.41200245
66positive regulation of mast cell degranulation (GO:0043306)3.41200245
67poly(A)+ mRNA export from nucleus (GO:0016973)3.40070836
68platelet degranulation (GO:0002576)3.39933036
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.39867383
70homotypic cell-cell adhesion (GO:0034109)3.38874866
71positive regulation of protein oligomerization (GO:0032461)3.32461926
72regulation of homotypic cell-cell adhesion (GO:0034110)3.31556027
73platelet activation (GO:0030168)3.28734459
74leukocyte degranulation (GO:0043299)3.28321437
75very-low-density lipoprotein particle assembly (GO:0034379)3.27819370
76positive regulation of receptor recycling (GO:0001921)3.26655253
77low-density lipoprotein particle remodeling (GO:0034374)3.24447361
78myeloid cell activation involved in immune response (GO:0002275)3.23186804
79glial cell migration (GO:0008347)3.21016231
80positive regulation of gamma-delta T cell activation (GO:0046645)3.14958448
81negative regulation of Ras GTPase activity (GO:0034261)3.14804700
82establishment or maintenance of monopolar cell polarity (GO:0061339)3.13781768
83establishment of monopolar cell polarity (GO:0061162)3.13781768
84positive regulation of cAMP-mediated signaling (GO:0043950)3.12328445
85positive regulation of systemic arterial blood pressure (GO:0003084)3.11878075
86negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.11357035
87negative regulation of cell cycle arrest (GO:0071157)3.09878615
88regulation of macrophage chemotaxis (GO:0010758)3.09210260
89platelet formation (GO:0030220)3.08634695
90regulation of hydrogen peroxide-induced cell death (GO:1903205)3.08270479
91DNA strand renaturation (GO:0000733)3.08025581
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.07330406
93negative regulation of T-helper cell differentiation (GO:0045623)3.07330406
94negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.06935467
95G1 DNA damage checkpoint (GO:0044783)3.06176226
96microglial cell activation (GO:0001774)3.05403935
97Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05244421
98regulation of response to reactive oxygen species (GO:1901031)3.05208997
99mitotic G1/S transition checkpoint (GO:0044819)3.03164468
100regulation of myeloid leukocyte mediated immunity (GO:0002886)3.02878262
101negative regulation of fatty acid metabolic process (GO:0045922)3.02361022
102regulation of macrophage derived foam cell differentiation (GO:0010743)3.01628980
103regulation of leukocyte degranulation (GO:0043300)3.01363815
104alkaloid metabolic process (GO:0009820)3.01024020
105positive regulation of granulocyte differentiation (GO:0030854)3.00577536
106negative regulation of response to reactive oxygen species (GO:1901032)3.00316710
107positive regulation of hemostasis (GO:1900048)2.99651234
108positive regulation of blood coagulation (GO:0030194)2.99651234
109response to peptidoglycan (GO:0032494)2.98933156
110negative regulation of cell killing (GO:0031342)2.98434137
111negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.98434137
112modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97957750
113modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97957750
114positive regulation by organism of defense response of other organism involved in symbiotic interact2.97957750
115modulation by symbiont of host immune response (GO:0052553)2.97957750
116positive regulation by symbiont of host defense response (GO:0052509)2.97957750
117modulation by symbiont of host defense response (GO:0052031)2.97957750
118hypotonic response (GO:0006971)2.96863544
119regulation of cAMP-dependent protein kinase activity (GO:2000479)2.96691104
120vascular endothelial growth factor signaling pathway (GO:0038084)2.96260305
121negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95592711
122heart trabecula formation (GO:0060347)2.94147228
123regulation of T-helper 2 cell differentiation (GO:0045628)2.93819766
124autophagic vacuole fusion (GO:0000046)2.93196037
125negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.93149205
126regulation of vascular permeability (GO:0043114)2.91704854
127regulation of translational fidelity (GO:0006450)2.90640860
128phagocytosis, engulfment (GO:0006911)2.90116012
129regulation of cholesterol homeostasis (GO:2000188)2.89817614
130peptide catabolic process (GO:0043171)2.88120843
131signal complex assembly (GO:0007172)2.86718017
132polyamine biosynthetic process (GO:0006596)2.86501371
133positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85945829
134cellular extravasation (GO:0045123)2.84822611
135positive regulation of developmental pigmentation (GO:0048087)2.84206464
136vesicle targeting (GO:0006903)2.83350258
137regulation of lipoprotein metabolic process (GO:0050746)2.83132309
138vitamin transmembrane transport (GO:0035461)2.82709644
139negative regulation of heart rate (GO:0010459)2.80538531
140N-glycan processing (GO:0006491)2.80293872
141positive regulation of coagulation (GO:0050820)2.79807137
142fusion of sperm to egg plasma membrane (GO:0007342)2.78895192
143DNA deamination (GO:0045006)2.78538329
144cellular response to thyroid hormone stimulus (GO:0097067)2.78247889
145regulation of T-helper 1 cell differentiation (GO:0045625)2.77427845
146positive regulation of B cell mediated immunity (GO:0002714)2.75138830
147positive regulation of immunoglobulin mediated immune response (GO:0002891)2.75138830
148positive regulation of Rho protein signal transduction (GO:0035025)2.75003234
149negative regulation of tumor necrosis factor production (GO:0032720)2.74620490
150protein targeting to vacuole (GO:0006623)2.74324606
151protein targeting to lysosome (GO:0006622)2.74324606
152establishment of protein localization to vacuole (GO:0072666)2.74324606
153negative regulation of T cell apoptotic process (GO:0070233)2.74219870
154negative regulation of stress fiber assembly (GO:0051497)2.73935756
155regulation of Golgi to plasma membrane protein transport (GO:0042996)2.73141518
156stress fiber assembly (GO:0043149)2.72726695
157face development (GO:0060324)2.72613425
158negative regulation of neural precursor cell proliferation (GO:2000178)2.72411931
159extracellular fibril organization (GO:0043206)2.72409253
160superoxide anion generation (GO:0042554)2.71325421
161synaptic vesicle endocytosis (GO:0048488)2.71155773
162dosage compensation (GO:0007549)2.70834109
163negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.70132539
164membrane invagination (GO:0010324)2.68699179
165apoptotic process involved in morphogenesis (GO:0060561)2.68564414
166cyclooxygenase pathway (GO:0019371)2.68499299
167convergent extension (GO:0060026)2.68198529
168negative regulation of interleukin-17 production (GO:0032700)2.66979745
169neuromuscular process controlling posture (GO:0050884)2.66791999
170activation of Rac GTPase activity (GO:0032863)2.66684244
171positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.65713755
172negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.65609523
173fibril organization (GO:0097435)2.64130519
174regulation of cholesterol efflux (GO:0010874)2.64006316
175intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.63459301
176positive regulation of actin cytoskeleton reorganization (GO:2000251)2.60418650
177regulation of mitochondrial depolarization (GO:0051900)2.59655995
178somatic diversification of immune receptors via somatic mutation (GO:0002566)2.57621347
179somatic hypermutation of immunoglobulin genes (GO:0016446)2.57621347
180protein retention in ER lumen (GO:0006621)2.57204260
181positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.56335088
182regulation of lamellipodium assembly (GO:0010591)2.53423912
183definitive hemopoiesis (GO:0060216)2.53318016
184glycogen catabolic process (GO:0005980)2.53283134
185positive regulation of lamellipodium assembly (GO:0010592)2.52945849
186positive regulation of lipid kinase activity (GO:0090218)2.52722744
187regulation of early endosome to late endosome transport (GO:2000641)2.48960789
188labyrinthine layer development (GO:0060711)2.48498954
189regulation of glomerular filtration (GO:0003093)2.48169468
190anatomical structure regression (GO:0060033)2.48011250
191retinoic acid receptor signaling pathway (GO:0048384)2.47976181
192regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.47355199
193positive regulation of cellular amide metabolic process (GO:0034250)2.47169331
194regulation of protein polyubiquitination (GO:1902914)2.46287593
195macroautophagy (GO:0016236)2.44725997
196fatty acid beta-oxidation (GO:0006635)2.43625207
197mitotic cell cycle arrest (GO:0071850)2.42355205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human4.17692859
2MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.01641961
3SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.97176546
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.61445694
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.56068080
6LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.52325777
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.36039972
8MYB_21317192_ChIP-Seq_ERMYB_Mouse2.89701902
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.73165772
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69765704
11GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.68231966
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.66986651
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.59485149
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58360433
15LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.57694551
16VDR_21846776_ChIP-Seq_THP-1_Human2.52087641
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.49700736
18* LXR_22292898_ChIP-Seq_THP-1_Human2.47983972
19TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.40267996
20GATA2_19941826_ChIP-Seq_K562_Human2.35130816
21* RUNX1_22412390_ChIP-Seq_EML_Mouse2.32875242
22PPARA_22158963_ChIP-Seq_LIVER_Mouse2.26916756
23* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.23850225
24MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.23808168
25GATA2_21666600_ChIP-Seq_HMVEC_Human2.22004213
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21236620
27KDM2B_26808549_Chip-Seq_SUP-B15_Human2.19078868
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17569652
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.16943006
30LXR_22158963_ChIP-Seq_LIVER_Mouse2.15168831
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14819867
32GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.14368377
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.12946291
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.12506709
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08293852
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.04016142
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.01578893
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.99463145
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96548690
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95074440
41GATA1_22025678_ChIP-Seq_K562_Human1.94241593
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.90947851
43CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.90524416
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87213497
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86967546
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84629550
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.84327746
48* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83524666
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.81092392
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.81092392
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.81092392
52RACK7_27058665_Chip-Seq_MCF-7_Human1.78477707
53* SPI1_23547873_ChIP-Seq_NB4_Human1.78407010
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.77818633
55PU.1_20513432_ChIP-Seq_Bcells_Mouse1.76550359
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74250476
57SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.71118169
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.69779609
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69209962
60* KDM2B_26808549_Chip-Seq_DND41_Human1.67855129
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.67702135
62RUNX_20019798_ChIP-Seq_JUKART_Human1.67112270
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66933648
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.64196329
65* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60657373
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.60652957
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.60065949
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59577300
69* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56598541
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55526122
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54892037
72GATA1_19941827_ChIP-Seq_MEL86_Mouse1.51549979
73KDM2B_26808549_Chip-Seq_K562_Human1.50875052
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48053068
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47627879
76NCOR1_26117541_ChIP-Seq_K562_Human1.44319790
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42900015
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42290297
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41668128
80* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39007500
81* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.36044967
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35193422
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34931444
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34676261
85MYB_26560356_Chip-Seq_TH2_Human1.33460178
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.32540353
87STAT1_20625510_ChIP-Seq_HELA_Human1.31478695
88* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30487079
89* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.28303461
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26988564
91* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26705015
92* TCF7_22412390_ChIP-Seq_EML_Mouse1.26429873
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25478903
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24772722
95TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22014989
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20708652
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20679469
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20145028
99MYC_22102868_ChIP-Seq_BL_Human1.20138421
100CDX2_20551321_ChIP-Seq_CACO-2_Human1.19661130
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18787480
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17808624
103* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17807761
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15503519
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15459797
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14699484
107ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14218205
108* BCOR_27268052_Chip-Seq_Bcells_Human1.13619048
109* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13462362
110* PU_27001747_Chip-Seq_BMDM_Mouse1.13361669
111MYB_26560356_Chip-Seq_TH1_Human1.13020392
112PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12900554
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.12746463
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12524655
115* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12198450
116* TET1_21451524_ChIP-Seq_MESCs_Mouse1.11551639
117STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11292024
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10051129
119TET1_21490601_ChIP-Seq_MESCs_Mouse1.09935056
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09454562
121GATA3_27048872_Chip-Seq_THYMUS_Human1.09332040
122VDR_24787735_ChIP-Seq_THP-1_Human1.07965449
123CTCF_27219007_Chip-Seq_Bcells_Human1.07435169
124* E2F1_20622854_ChIP-Seq_HELA_Human1.07116380
125MAF_26560356_Chip-Seq_TH1_Human1.06850982
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06688764
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06455586
128TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06411532
129* ETS1_21867929_ChIP-Seq_TH2_Mouse1.06136805
130CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05486495
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05251574
132VDR_24763502_ChIP-Seq_THP-1_Human1.04938291
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04918904
134CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04844486
135* SPI1_20517297_ChIP-Seq_HL60_Human1.04719358
136GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04639059
137STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04031024
138GATA1_19941826_ChIP-Seq_K562_Human1.03774823
139CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02822108
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02735340
141UTX_26944678_Chip-Seq_JUKART_Human1.02491646
142* KDM2B_26808549_Chip-Seq_JURKAT_Human1.01319522
143TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01147427
144ZNF263_19887448_ChIP-Seq_K562_Human1.00581226
145RARB_24833708_ChIP-Seq_LIVER_Mouse1.00496519
146KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00387021
147NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99734334
148IRF8_22096565_ChIP-ChIP_GC-B_Human0.99324585
149NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98752012
150* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98379135
151ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98326655
152SPI1_23127762_ChIP-Seq_K562_Human0.97840152
153ETS1_22383799_ChIP-Seq_G1ME_Mouse0.97110519
154MAF_26560356_Chip-Seq_TH2_Human0.96527937
155SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96125784
156SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95972133
157TBX20_22080862_ChIP-Seq_HEART_Mouse0.95615472
158TBX20_22328084_ChIP-Seq_HEART_Mouse0.95615472
159MYC_27129775_Chip-Seq_CORNEA_Mouse0.95348816
160TFEB_21752829_ChIP-Seq_HELA_Human0.95114305
161TP53_23651856_ChIP-Seq_MEFs_Mouse0.93651762
162SMAD_19615063_ChIP-ChIP_OVARY_Human0.92614707
163JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90602864
164RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90068587
165HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88542606
166GATA3_26560356_Chip-Seq_TH2_Human0.87747436
167* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86182351
168* BCL6_27268052_Chip-Seq_Bcells_Human0.85877937
169SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82843137
170* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81935565
171JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81053924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH4.50161090
2MP0003724_increased_susceptibility_to4.34335028
3MP0005058_abnormal_lysosome_morphology3.97513687
4MP0009278_abnormal_bone_marrow3.70404313
5MP0004233_abnormal_muscle_weight3.64468301
6MP0008057_abnormal_DNA_replication3.36089560
7MP0005171_absent_coat_pigmentation3.34450971
8MP0000465_gastrointestinal_hemorrhage3.07904449
9MP0004510_myositis2.93849766
10MP0001835_abnormal_antigen_presentation2.87308873
11MP0005365_abnormal_bile_salt2.82899000
12MP0003172_abnormal_lysosome_physiology2.79157730
13MP0005085_abnormal_gallbladder_physiolo2.67247774
14MP0002009_preneoplasia2.59461017
15MP0003436_decreased_susceptibility_to2.58006534
16MP0009840_abnormal_foam_cell2.16420350
17MP0002148_abnormal_hypersensitivity_rea2.14691233
18MP0005000_abnormal_immune_tolerance2.02903935
19MP0005167_abnormal_blood-brain_barrier2.01479001
20MP0004130_abnormal_muscle_cell1.99270876
21MP0005670_abnormal_white_adipose1.96037688
22MP0002269_muscular_atrophy1.93650864
23MP0003828_pulmonary_edema1.90731211
24MP0003806_abnormal_nucleotide_metabolis1.88464800
25MP0005671_abnormal_response_to1.85295368
26MP0002419_abnormal_innate_immunity1.84979003
27MP0003300_gastrointestinal_ulcer1.83624228
28MP0010155_abnormal_intestine_physiology1.80693702
29MP0004019_abnormal_vitamin_homeostasis1.79747199
30MP0003453_abnormal_keratinocyte_physiol1.79488665
31MP0002723_abnormal_immune_serum1.75292618
32MP0001800_abnormal_humoral_immune1.73902939
33MP0002452_abnormal_antigen_presenting1.72524544
34MP0005330_cardiomyopathy1.70928232
35MP0010630_abnormal_cardiac_muscle1.70126195
36MP0004947_skin_inflammation1.69951574
37MP0001851_eye_inflammation1.69319979
38MP0001533_abnormal_skeleton_physiology1.68787166
39MP0006082_CNS_inflammation1.65980028
40MP0002398_abnormal_bone_marrow1.64949314
41MP0001873_stomach_inflammation1.62489272
42MP0005387_immune_system_phenotype1.59194629
43MP0001790_abnormal_immune_system1.59194629
44MP0005025_abnormal_response_to1.59124084
45MP0005076_abnormal_cell_differentiation1.58668881
46MP0000858_altered_metastatic_potential1.53595020
47MP0002420_abnormal_adaptive_immunity1.52681830
48MP0000751_myopathy1.51612416
49MP0001819_abnormal_immune_cell1.50846661
50MP0003567_abnormal_fetal_cardiomyocyte1.48617795
51MP0001545_abnormal_hematopoietic_system1.47514434
52MP0005397_hematopoietic_system_phenotyp1.47514434
53MP0005360_urolithiasis1.46206655
54MP0008995_early_reproductive_senescence1.44566003
55MP0000579_abnormal_nail_morphology1.43672538
56MP0009764_decreased_sensitivity_to1.43132707
57MP0002139_abnormal_hepatobiliary_system1.42756458
58MP0002166_altered_tumor_susceptibility1.39559174
59MP0005083_abnormal_biliary_tract1.39199258
60MP0010030_abnormal_orbit_morphology1.39158738
61MP0003191_abnormal_cellular_cholesterol1.38538038
62MP0006072_abnormal_retinal_apoptosis1.38494918
63MP0003075_altered_response_to1.37386711
64MP0000230_abnormal_systemic_arterial1.35849812
65MP0000685_abnormal_immune_system1.35567954
66MP0006138_congestive_heart_failure1.34667191
67MP0000470_abnormal_stomach_morphology1.34624531
68MP0001845_abnormal_inflammatory_respons1.32279426
69MP0008260_abnormal_autophagy1.32177695
70MP0002132_abnormal_respiratory_system1.30959814
71MP0009115_abnormal_fat_cell1.30323558
72MP0002837_dystrophic_cardiac_calcinosis1.30066718
73MP0009785_altered_susceptibility_to1.29138665
74MP0001663_abnormal_digestive_system1.28798945
75MP0003137_abnormal_impulse_conducting1.28666769
76MP0002998_abnormal_bone_remodeling1.28213526
77MP0004087_abnormal_muscle_fiber1.27757972
78MP0000689_abnormal_spleen_morphology1.27733988
79MP0000249_abnormal_blood_vessel1.26162887
80MP0003656_abnormal_erythrocyte_physiolo1.25888144
81MP0002429_abnormal_blood_cell1.25411727
82MP0000716_abnormal_immune_system1.24751385
83MP0010329_abnormal_lipoprotein_level1.24505505
84MP0004084_abnormal_cardiac_muscle1.22763133
85MP0002118_abnormal_lipid_homeostasis1.18445350
86MP0003283_abnormal_digestive_organ1.18199912
87MP0009763_increased_sensitivity_to1.17999973
88MP0002722_abnormal_immune_system1.17572215
89MP0003638_abnormal_response/metabolism_1.16803336
90MP0000371_diluted_coat_color1.16094879
91MP0003045_fibrosis1.14544021
92MP0009333_abnormal_splenocyte_physiolog1.14187891
93MP0002108_abnormal_muscle_morphology1.13841033
94MP0000639_abnormal_adrenal_gland1.12760993
95MP0005165_increased_susceptibility_to1.08223060
96MP0005409_darkened_coat_color1.07489401
97MP0000015_abnormal_ear_pigmentation1.05495003
98MP0005410_abnormal_fertilization1.05229015
99MP0003705_abnormal_hypodermis_morpholog1.05011543
100MP0002877_abnormal_melanocyte_morpholog1.04893353
101MP0003091_abnormal_cell_migration1.04465095
102MP0006054_spinal_hemorrhage1.03440858
103MP0003763_abnormal_thymus_physiology1.03012485
104MP0001879_abnormal_lymphatic_vessel1.02525843
105MP0002971_abnormal_brown_adipose1.02327419
106MP0002106_abnormal_muscle_physiology1.01187515
107MP0005369_muscle_phenotype0.98049180
108MP0003690_abnormal_glial_cell0.97866984
109MP0008775_abnormal_heart_ventricle0.97058521
110MP0005332_abnormal_amino_acid0.96879701
111MP0002796_impaired_skin_barrier0.96829470
112MP0004883_abnormal_blood_vessel0.96761450
113MP0000747_muscle_weakness0.96645156
114MP0004036_abnormal_muscle_relaxation0.95511991
115MP0005084_abnormal_gallbladder_morpholo0.94574146
116MP0005023_abnormal_wound_healing0.93286917
117MP0000609_abnormal_liver_physiology0.93192726
118MP0003866_abnormal_defecation0.92703664
119MP0003879_abnormal_hair_cell0.91883708
120MP0005464_abnormal_platelet_physiology0.91772834
121MP0004185_abnormal_adipocyte_glucose0.90482515
122MP0002086_abnormal_extraembryonic_tissu0.89962923
123MP0002736_abnormal_nociception_after0.89581218
124MP0005666_abnormal_adipose_tissue0.88299976
125MP0003448_altered_tumor_morphology0.88233079
126MP0005310_abnormal_salivary_gland0.87184472
127MP0003633_abnormal_nervous_system0.86734979
128MP0001666_abnormal_nutrient_absorption0.86579049
129MP0009765_abnormal_xenobiotic_induced0.85261722
130MP0005266_abnormal_metabolism0.84518906
131MP0001324_abnormal_eye_pigmentation0.83272397
132MP0002006_tumorigenesis0.82945871
133MP0003183_abnormal_peptide_metabolism0.82537246
134MP0000703_abnormal_thymus_morphology0.81654400
135MP0005385_cardiovascular_system_phenoty0.81604636
136MP0001544_abnormal_cardiovascular_syste0.81604636
137MP0003890_abnormal_embryonic-extraembry0.81462322
138MP0000759_abnormal_skeletal_muscle0.81031738
139MP0004808_abnormal_hematopoietic_stem0.80089315
140MP0005319_abnormal_enzyme/_coenzyme0.79717837
141MP0003566_abnormal_cell_adhesion0.79235169
142MP0008469_abnormal_protein_level0.76908294
143MP0004484_altered_response_of0.76074937
144MP0005381_digestive/alimentary_phenotyp0.75922644
145MP0009642_abnormal_blood_homeostasis0.75346969
146MP0005174_abnormal_tail_pigmentation0.74260624
147MP0003943_abnormal_hepatobiliary_system0.73269334
148MP0005164_abnormal_response_to0.72937979
149MP0001915_intracranial_hemorrhage0.72899120
150MP0003634_abnormal_glial_cell0.72704343
151MP0002405_respiratory_system_inflammati0.72704014
152MP0005075_abnormal_melanosome_morpholog0.72396604
153MP0002332_abnormal_exercise_endurance0.71893503
154MP0000490_abnormal_crypts_of0.70814334
155MP0000343_altered_response_to0.70383269
156MP0001765_abnormal_ion_homeostasis0.68844127
157MP0003795_abnormal_bone_structure0.68237976
158MP0001784_abnormal_fluid_regulation0.67787102
159MP0005375_adipose_tissue_phenotype0.67730044
160MP0008874_decreased_physiological_sensi0.67442036
161MP0004133_heterotaxia0.66982694
162MP0008872_abnormal_physiological_respon0.66794112
163MP0002060_abnormal_skin_morphology0.65939760
164MP0004264_abnormal_extraembryonic_tissu0.65546720
165MP0008875_abnormal_xenobiotic_pharmacok0.65182716
166MP0005166_decreased_susceptibility_to0.65135221
167MP0000266_abnormal_heart_morphology0.63831206
168MP0003303_peritoneal_inflammation0.63327351
169MP0003631_nervous_system_phenotype0.62072638
170MP0000598_abnormal_liver_morphology0.61637557
171MP0009643_abnormal_urine_homeostasis0.61308170
172MP0005334_abnormal_fat_pad0.60724152

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)9.39829134
2Menorrhagia (HP:0000132)9.12542391
3Abnormal platelet volume (HP:0011876)9.04879375
4Purpura (HP:0000979)8.31836083
5Epistaxis (HP:0000421)7.27510750
6Gingival bleeding (HP:0000225)6.34225751
7Annular pancreas (HP:0001734)5.54696446
8Abnormal platelet function (HP:0011869)5.33017205
9Impaired platelet aggregation (HP:0003540)5.33017205
10Turricephaly (HP:0000262)5.17126396
11Spontaneous hematomas (HP:0007420)4.80528505
12Pustule (HP:0200039)4.63397866
13Hyperlipoproteinemia (HP:0010980)4.57291145
14Pancreatic islet-cell hyperplasia (HP:0004510)4.51119180
15Dysostosis multiplex (HP:0000943)4.50911558
16Mucopolysacchariduria (HP:0008155)4.37306625
17Urinary glycosaminoglycan excretion (HP:0003541)4.37306625
18Abnormality of polysaccharide metabolism (HP:0011012)4.09085239
19Abnormality of glycosaminoglycan metabolism (HP:0004371)4.09085239
20Abnormality of mucopolysaccharide metabolism (HP:0011020)4.09085239
21Ulnar bowing (HP:0003031)4.01702004
22Alopecia of scalp (HP:0002293)3.91619676
23Dyschromatopsia (HP:0007641)3.87499123
24Asymmetric septal hypertrophy (HP:0001670)3.75947108
25Abnormality of macrophages (HP:0004311)3.73721710
26Conjunctival telangiectasia (HP:0000524)3.62659086
27Increased CSF protein (HP:0002922)3.51645813
28Abnormality of the vasculature of the conjunctiva (HP:0008054)3.49512140
29Abnormality of the aortic arch (HP:0012303)3.47914974
30Increased IgM level (HP:0003496)3.47020301
31Poikilocytosis (HP:0004447)3.46379323
32Bruising susceptibility (HP:0000978)3.38318276
33Abnormality of the common coagulation pathway (HP:0010990)3.35972545
34Acanthocytosis (HP:0001927)3.31074713
35Rib fusion (HP:0000902)3.29995693
36Growth hormone excess (HP:0000845)3.28178603
37Hypochromic microcytic anemia (HP:0004840)3.25272418
38Exercise-induced myalgia (HP:0003738)3.20013544
39Facial hemangioma (HP:0000329)3.10750646
40Rectovaginal fistula (HP:0000143)3.09843979
41Rectal fistula (HP:0100590)3.09843979
42Male infertility (HP:0003251)3.08087614
43Large for gestational age (HP:0001520)3.06043902
44Vaginal fistula (HP:0004320)3.03997744
45Coronal craniosynostosis (HP:0004440)3.03362358
46Abnormality of the pancreatic islet cells (HP:0006476)3.03046929
47Abnormality of endocrine pancreas physiology (HP:0012093)3.03046929
48Poikiloderma (HP:0001029)3.01612156
49Polycythemia (HP:0001901)2.97608400
50Hyperinsulinemic hypoglycemia (HP:0000825)2.94798158
51Stomatitis (HP:0010280)2.93815810
52Intestinal fistula (HP:0100819)2.89848395
53Paralysis (HP:0003470)2.86146076
54Increased density of long bones (HP:0006392)2.85288495
55Cerebral aneurysm (HP:0004944)2.83406535
56Colitis (HP:0002583)2.82989870
57Recurrent bacterial skin infections (HP:0005406)2.82573218
58Recurrent abscess formation (HP:0002722)2.80520705
59Hepatosplenomegaly (HP:0001433)2.77026702
60Clumsiness (HP:0002312)2.73852306
61Ketoacidosis (HP:0001993)2.69659815
62Chronic obstructive pulmonary disease (HP:0006510)2.67379804
63Obstructive lung disease (HP:0006536)2.67379804
64Abnormality of the heme biosynthetic pathway (HP:0010472)2.64409119
65Premature skin wrinkling (HP:0100678)2.63927465
66Concave nail (HP:0001598)2.58545348
67Intestinal atresia (HP:0011100)2.58210323
68Short humerus (HP:0005792)2.50865724
69Anteriorly placed anus (HP:0001545)2.49377239
70Abnormality of iron homeostasis (HP:0011031)2.49042123
71Myocardial infarction (HP:0001658)2.45571101
72Abnormal pupillary function (HP:0007686)2.45115367
73Abnormality of male internal genitalia (HP:0000022)2.43387096
74Abnormality of the periventricular white matter (HP:0002518)2.41445536
75Lower limb hyperreflexia (HP:0002395)2.39884860
76Arterial thrombosis (HP:0004420)2.38735621
77Joint stiffness (HP:0001387)2.38006934
78Muscle fibrillation (HP:0010546)2.34603347
79Hypokinesia (HP:0002375)2.34077835
80Hypoglycemic coma (HP:0001325)2.33388052
81Tongue fasciculations (HP:0001308)2.31168036
82Abnormal hemoglobin (HP:0011902)2.30895441
83Congenital hip dislocation (HP:0001374)2.30595395
84Alacrima (HP:0000522)2.30579930
85Generalized amyotrophy (HP:0003700)2.30475507
86Encephalitis (HP:0002383)2.26601249
87Joint swelling (HP:0001386)2.24932770
88Increased serum ferritin (HP:0003281)2.22750297
89Ketosis (HP:0001946)2.20425011
90Albinism (HP:0001022)2.19592940
91Orthostatic hypotension (HP:0001278)2.16977788
92Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.14057161
93Vertebral hypoplasia (HP:0008417)2.14057161
94Tetany (HP:0001281)2.13808830
95Diaphragmatic weakness (HP:0009113)2.13040382
96Aplasia/hypoplasia of the humerus (HP:0006507)2.11602820
97Hypoglycemic seizures (HP:0002173)2.07210113
98Episodic fever (HP:0001954)2.07126454
99Bowed forearm bones (HP:0003956)2.06359033
100Bowing of the arm (HP:0006488)2.06359033
101Abnormality of fatty-acid metabolism (HP:0004359)2.05840669
102Increased circulating renin level (HP:0000848)2.04945896
103Hypotrichosis (HP:0001006)2.03741785
104Chest pain (HP:0100749)2.01248596
105Abnormality of transition element cation homeostasis (HP:0011030)2.01195125
106Prolonged bleeding time (HP:0003010)10.5271345
107Short chin (HP:0000331)1.99899730
108Myoglobinuria (HP:0002913)1.98664347
109Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93470365
110Abnormality of aromatic amino acid family metabolism (HP:0004338)1.91740371
111Abnormality of lateral ventricle (HP:0030047)1.91486542
112Thrombocytosis (HP:0001894)1.91080860
113Vacuolated lymphocytes (HP:0001922)1.90639829
114Exercise-induced muscle cramps (HP:0003710)1.90398112
115Autoimmune thrombocytopenia (HP:0001973)1.89948308
116Dysautonomia (HP:0002459)1.88950674
117Decreased central vision (HP:0007663)1.88532482
118Inflammation of the large intestine (HP:0002037)1.88011889
119Choanal stenosis (HP:0000452)1.87665957
120IgA deficiency (HP:0002720)1.87332966
121Tinnitus (HP:0000360)1.86152800
122Hypochromic anemia (HP:0001931)1.86085031
123Myositis (HP:0100614)1.85912236
124Increased neuronal autofluorescent lipopigment (HP:0002074)1.85101266
125Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.84766894
126Increased cerebral lipofuscin (HP:0011813)1.84439320
127Hypercortisolism (HP:0001578)1.81774182
128Elevated erythrocyte sedimentation rate (HP:0003565)1.81436475
129Aplasia of the musculature (HP:0100854)1.81432578
130Basal ganglia calcification (HP:0002135)1.81209856
131Bilateral sensorineural hearing impairment (HP:0008619)1.81140101
132Distal lower limb amyotrophy (HP:0008944)1.79864230
133Xanthomatosis (HP:0000991)1.79507510
134Split hand (HP:0001171)1.79078706
135Orchitis (HP:0100796)1.78721508
136Abnormality of T cell physiology (HP:0011840)1.77553844
137Recurrent fungal infections (HP:0002841)1.77499164
138Optic neuritis (HP:0100653)1.76443757
139Retrobulbar optic neuritis (HP:0100654)1.76443757
140Joint hemorrhage (HP:0005261)1.75977255
141Acute hepatic failure (HP:0006554)1.75892644
142Hemorrhage of the eye (HP:0011885)1.74258450
143Hamartoma (HP:0010566)1.74252629
144Petechiae (HP:0000967)1.74166309
145Hypoplastic ischia (HP:0003175)1.74135737
146Intrahepatic cholestasis (HP:0001406)1.73841869
147Gastrointestinal inflammation (HP:0004386)1.73513370
148Coarse hair (HP:0002208)1.73496351
149Eczematoid dermatitis (HP:0000976)1.72320368
150Autoimmune hemolytic anemia (HP:0001890)1.71557753
151Upper limb muscle weakness (HP:0003484)1.71390422
152Peripheral demyelination (HP:0011096)1.70848146
153Vertigo (HP:0002321)1.70775486
154Leukocytosis (HP:0001974)1.70721805
155Nausea (HP:0002018)1.69498621
156Systemic lupus erythematosus (HP:0002725)1.69257818
157Mucosal telangiectasiae (HP:0100579)1.68901929
158Recurrent gram-negative bacterial infections (HP:0005420)1.67437111
159Capillary hemangiomas (HP:0005306)1.65905840
160Hypophosphatemic rickets (HP:0004912)1.61541358
161Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.61374439
162Gastrointestinal infarctions (HP:0005244)1.61208807
163Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.60827592
164Recurrent skin infections (HP:0001581)1.59444607
165Ventricular fibrillation (HP:0001663)1.58762285
166Cerebral ischemia (HP:0002637)1.57741061
167Vasculitis (HP:0002633)1.57226358
168Hypertriglyceridemia (HP:0002155)1.56791679
169Hyperthyroidism (HP:0000836)1.56039711
170Granulocytopenia (HP:0001913)1.55519300
171Thrombophlebitis (HP:0004418)1.55153010
172Pulmonary embolism (HP:0002204)1.54868950
173Amaurosis fugax (HP:0100576)1.53084087
174Meningitis (HP:0001287)1.52745484
175Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.50723131
176Spontaneous abortion (HP:0005268)1.50516798
177Abnormal auditory evoked potentials (HP:0006958)1.50412454
178Testicular neoplasm (HP:0010788)1.49606844
179Gingivitis (HP:0000230)1.49452415
180Papillary thyroid carcinoma (HP:0002895)1.48907601
181Arthralgia (HP:0002829)1.48465660
182Abnormality of glycolipid metabolism (HP:0010969)1.45038551
183Abnormality of liposaccharide metabolism (HP:0010968)1.45038551
184Abnormality of glycosphingolipid metabolism (HP:0004343)1.45038551
185Abnormality of the prostate (HP:0008775)1.44081231
186T lymphocytopenia (HP:0005403)1.42914556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE18.13320342
2ICK5.25448139
3MAPK154.01959414
4MST43.64223606
5MAP3K63.57422470
6DDR23.49243271
7PINK13.03278509
8BTK2.93032085
9MYLK2.60596592
10FGR2.46439966
11MAP3K112.34630400
12ZAP702.33891179
13SYK2.32322300
14CSF1R2.29958926
15GRK62.24476536
16MAP2K32.21406538
17PTK2B2.17986318
18TRPM72.17604159
19CAMK1D2.13950953
20EIF2AK12.11231414
21MATK2.01211277
22BMPR21.93084267
23CSK1.93054498
24TYRO31.86873682
25UHMK11.84944306
26PIK3CG1.77943308
27PRKD21.74703793
28PDGFRA1.73484358
29FES1.73253800
30DYRK1B1.67090710
31CAMK1G1.65422926
32HCK1.65129548
33GRK51.57942923
34IRAK31.50773288
35IKBKB1.47525171
36PHKG21.43415957
37PHKG11.43415957
38DAPK11.41457005
39TEC1.32807573
40ACVR1B1.32379139
41ILK1.31829239
42JAK31.25100411
43GRK11.23536208
44MAP3K31.23262937
45TESK21.16889578
46IRAK41.15567813
47MARK31.15366123
48TRIB31.15052181
49YES11.14655942
50PIM21.10908947
51TAOK21.09030412
52STK241.08940098
53TTN1.08138625
54SIK31.06496180
55STK31.05533611
56TAOK31.04054786
57MAPK111.01734778
58DMPK1.01620477
59TAOK11.01344249
60CDK61.00596794
61RPS6KL10.99904307
62RPS6KC10.99904307
63PAK10.99267163
64PDK10.98207474
65ADRBK20.98138243
66GSK3A0.96046191
67IRAK10.96024319
68ITK0.94347879
69CDC42BPA0.92780841
70ARAF0.90581354
71RPS6KA60.89878669
72MAPKAPK30.87422816
73* BMX0.86587601
74TYK20.86522086
75MAP3K50.86153952
76MAP3K140.85991706
77RIPK10.85680018
78AKT30.84413865
79PRKAA10.83284710
80INSRR0.82591352
81IKBKE0.78449066
82HIPK20.77898717
83TXK0.77752240
84IRAK20.77439898
85DAPK30.76760433
86MAP3K10.75086341
87PRKAA20.73580191
88LCK0.72407393
89CAMKK20.72286897
90PIM10.71951627
91STK40.69958239
92EPHB10.69739089
93MAP4K10.68732918
94ADRBK10.68717327
95LMTK20.67849155
96RET0.67532756
97MTOR0.66806701
98EGFR0.66224269
99CDK70.64600096
100MAPK120.58668299
101BCKDK0.58542119
102LATS20.58509952
103PRKD10.58148118
104PKN20.55759717
105RPS6KA10.48928967
106ERBB20.47696358
107FYN0.47355964
108DAPK20.46496268
109ERN10.46209962
110SGK10.41618762
111CDK120.41367743
112CAMK2D0.39464870
113EPHA30.38700035
114PDGFRB0.38283795
115MAP3K100.37957856
116LRRK20.37261288
117CAMK40.37223228
118PKN10.37108187
119MAP2K10.34267830
120NEK90.33721581
121CAMK2G0.33382462
122CAMK2B0.32245528
123SIK10.31709458
124PRKCQ0.31655588
125TLK10.31045553
126PRKCD0.30998951
127TGFBR20.30568991
128PDPK10.30291801
129LYN0.30084611
130PTK20.29542736
131SGK30.29338398
132GRK70.29122203
133MAPK100.28910902
134MAP2K20.28871669
135JAK20.28763666
136PRPF4B0.27710894
137KDR0.27420816
138PRKCZ0.27176119
139EPHB20.27154027
140TNK20.26893462
141MAPK30.26667473
142RAF10.25942578
143INSR0.25626103
144PRKCH0.24037123
145MAPK10.23918480
146BLK0.22108240
147CAMK2A0.21654768
148MAPK40.21604710
149RPS6KA30.21257698
150RPS6KB10.21219800
151STK100.20566520
152PRKACG0.20399051
153MAP3K90.19846421
154MARK20.19192839
155JAK10.18843269
156TBK10.18200212
157ALK0.17578765
158LATS10.16950532
159ABL10.16287206
160STK380.14524027
161RIPK40.14484590
162AKT20.14170785
163KIT0.14051991
164MAPKAPK20.12457091
165MAP3K70.11270566

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.66838386
2Platelet activation_Homo sapiens_hsa046114.29992819
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.90999854
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.75873531
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.54839775
6Fatty acid metabolism_Homo sapiens_hsa012122.49320018
7Hematopoietic cell lineage_Homo sapiens_hsa046402.40525977
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.19738002
9Arginine and proline metabolism_Homo sapiens_hsa003302.18046022
10mTOR signaling pathway_Homo sapiens_hsa041502.03019200
11Osteoclast differentiation_Homo sapiens_hsa043802.00317915
12Arginine biosynthesis_Homo sapiens_hsa002201.97728557
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.97293611
14Circadian rhythm_Homo sapiens_hsa047101.92679107
15Longevity regulating pathway - mammal_Homo sapiens_hsa042111.92538916
16Chemokine signaling pathway_Homo sapiens_hsa040621.86896440
17Base excision repair_Homo sapiens_hsa034101.81254909
18Notch signaling pathway_Homo sapiens_hsa043301.77998376
19Adherens junction_Homo sapiens_hsa045201.74612120
20Lysine degradation_Homo sapiens_hsa003101.68073449
21Bile secretion_Homo sapiens_hsa049761.66317270
22PPAR signaling pathway_Homo sapiens_hsa033201.60693909
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59385213
24Leishmaniasis_Homo sapiens_hsa051401.55371712
25Malaria_Homo sapiens_hsa051441.54639591
26Fructose and mannose metabolism_Homo sapiens_hsa000511.54142322
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.53240568
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.51098975
29Biosynthesis of amino acids_Homo sapiens_hsa012301.47321894
30Lysosome_Homo sapiens_hsa041421.47019238
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43348730
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41974670
33ABC transporters_Homo sapiens_hsa020101.41141241
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.40961986
35ECM-receptor interaction_Homo sapiens_hsa045121.38485452
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37883150
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35972905
38Phagosome_Homo sapiens_hsa041451.33635951
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.33289142
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33199180
41Fatty acid degradation_Homo sapiens_hsa000711.30731601
42Tryptophan metabolism_Homo sapiens_hsa003801.30143610
43Nitrogen metabolism_Homo sapiens_hsa009101.29235624
44Tuberculosis_Homo sapiens_hsa051521.28438639
45Arachidonic acid metabolism_Homo sapiens_hsa005901.27974218
46T cell receptor signaling pathway_Homo sapiens_hsa046601.25929575
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23745451
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.14145888
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14118455
50Pancreatic cancer_Homo sapiens_hsa052121.11244279
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09845689
52Staphylococcus aureus infection_Homo sapiens_hsa051501.08608448
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08189260
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07940653
55Propanoate metabolism_Homo sapiens_hsa006401.06627689
56Systemic lupus erythematosus_Homo sapiens_hsa053221.05883549
57VEGF signaling pathway_Homo sapiens_hsa043701.04525305
58Collecting duct acid secretion_Homo sapiens_hsa049661.03555018
59AMPK signaling pathway_Homo sapiens_hsa041521.01942172
60Non-small cell lung cancer_Homo sapiens_hsa052231.01862036
61Graft-versus-host disease_Homo sapiens_hsa053321.01055732
62Allograft rejection_Homo sapiens_hsa053301.00005078
63Asthma_Homo sapiens_hsa053100.99255360
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.98143316
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.96646036
66HIF-1 signaling pathway_Homo sapiens_hsa040660.95974882
67Dorso-ventral axis formation_Homo sapiens_hsa043200.95395868
68Toxoplasmosis_Homo sapiens_hsa051450.95167988
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94951884
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91625472
71Choline metabolism in cancer_Homo sapiens_hsa052310.91453767
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90672369
73Insulin signaling pathway_Homo sapiens_hsa049100.89559316
74Salmonella infection_Homo sapiens_hsa051320.89109826
75TNF signaling pathway_Homo sapiens_hsa046680.87762787
76Apoptosis_Homo sapiens_hsa042100.86472128
77Autoimmune thyroid disease_Homo sapiens_hsa053200.86452711
78Fatty acid elongation_Homo sapiens_hsa000620.86376683
79B cell receptor signaling pathway_Homo sapiens_hsa046620.85568934
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.84726097
81Peroxisome_Homo sapiens_hsa041460.83297833
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83285149
83Folate biosynthesis_Homo sapiens_hsa007900.82393184
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81715653
85Measles_Homo sapiens_hsa051620.80254324
86Butanoate metabolism_Homo sapiens_hsa006500.79449265
87beta-Alanine metabolism_Homo sapiens_hsa004100.79330769
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79117697
89Starch and sucrose metabolism_Homo sapiens_hsa005000.78691177
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77994077
91Endometrial cancer_Homo sapiens_hsa052130.77591290
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77557214
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.77163431
94Renal cell carcinoma_Homo sapiens_hsa052110.76419332
95Amoebiasis_Homo sapiens_hsa051460.76308064
96Alcoholism_Homo sapiens_hsa050340.76102761
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75469173
98Serotonergic synapse_Homo sapiens_hsa047260.73374425
99Histidine metabolism_Homo sapiens_hsa003400.73208499
100Influenza A_Homo sapiens_hsa051640.73128657
101Shigellosis_Homo sapiens_hsa051310.72605893
102Viral carcinogenesis_Homo sapiens_hsa052030.72540801
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.71415529
104Acute myeloid leukemia_Homo sapiens_hsa052210.69907438
105Complement and coagulation cascades_Homo sapiens_hsa046100.69139673
106Hippo signaling pathway_Homo sapiens_hsa043900.68677563
107Viral myocarditis_Homo sapiens_hsa054160.66810121
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66612196
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66073832
110Other glycan degradation_Homo sapiens_hsa005110.65957224
111Primary immunodeficiency_Homo sapiens_hsa053400.65088988
112Pertussis_Homo sapiens_hsa051330.64553225
113Ovarian steroidogenesis_Homo sapiens_hsa049130.63776085
114Hepatitis C_Homo sapiens_hsa051600.63313644
115Insulin resistance_Homo sapiens_hsa049310.63018624
116Glycerolipid metabolism_Homo sapiens_hsa005610.62769439
117Hepatitis B_Homo sapiens_hsa051610.62579425
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61943384
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61880756
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.61220093
121Bladder cancer_Homo sapiens_hsa052190.61216684
122Sphingolipid metabolism_Homo sapiens_hsa006000.60967363
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60818829
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60741407
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60303822
126Mismatch repair_Homo sapiens_hsa034300.60146660
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59891929
128Herpes simplex infection_Homo sapiens_hsa051680.59734808
129Glucagon signaling pathway_Homo sapiens_hsa049220.58869599
130Pancreatic secretion_Homo sapiens_hsa049720.58178858
131Estrogen signaling pathway_Homo sapiens_hsa049150.57151524
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56085648
133Renin-angiotensin system_Homo sapiens_hsa046140.56032075
134Dilated cardiomyopathy_Homo sapiens_hsa054140.55231115
135Rheumatoid arthritis_Homo sapiens_hsa053230.54760673
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54356377
137Phenylalanine metabolism_Homo sapiens_hsa003600.53711457
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53373609
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53300722
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53047353
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.51859140
142Small cell lung cancer_Homo sapiens_hsa052220.50947441
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.50645465
144Long-term depression_Homo sapiens_hsa047300.49154087
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49057133
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48631422
147TGF-beta signaling pathway_Homo sapiens_hsa043500.47854811
148Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46210112
149Ras signaling pathway_Homo sapiens_hsa040140.46044653
150Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44908274
151GnRH signaling pathway_Homo sapiens_hsa049120.44833501
152Gap junction_Homo sapiens_hsa045400.44668842
153* Endocytosis_Homo sapiens_hsa041440.44525476
154Legionellosis_Homo sapiens_hsa051340.43866735
155Fat digestion and absorption_Homo sapiens_hsa049750.43448556
156Tight junction_Homo sapiens_hsa045300.41317035
157Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39313609
158Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38931994
159Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38727879
160Vitamin digestion and absorption_Homo sapiens_hsa049770.38323500
161Mineral absorption_Homo sapiens_hsa049780.37001801
162Rap1 signaling pathway_Homo sapiens_hsa040150.36944642
163Gastric acid secretion_Homo sapiens_hsa049710.36379440
164ErbB signaling pathway_Homo sapiens_hsa040120.36170484
165Hedgehog signaling pathway_Homo sapiens_hsa043400.36014430
166Proteoglycans in cancer_Homo sapiens_hsa052050.35320948
167Chronic myeloid leukemia_Homo sapiens_hsa052200.34408835
168Steroid biosynthesis_Homo sapiens_hsa001000.34408153
169Carbon metabolism_Homo sapiens_hsa012000.34204698
170Focal adhesion_Homo sapiens_hsa045100.33269900
171Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32653579

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