RTP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.04366756
2type I interferon signaling pathway (GO:0060337)6.61180626
3cellular response to type I interferon (GO:0071357)6.61180626
4response to type I interferon (GO:0034340)6.57066934
5positive regulation of interferon-alpha production (GO:0032727)5.96671185
6response to interferon-alpha (GO:0035455)5.76790219
7regulation of interferon-alpha production (GO:0032647)5.62061738
8cellular response to interferon-beta (GO:0035458)5.42895352
9response to interferon-beta (GO:0035456)5.41543994
10immunoglobulin mediated immune response (GO:0016064)5.00618818
11cellular response to interferon-alpha (GO:0035457)4.91706954
12cellular response to exogenous dsRNA (GO:0071360)4.86367840
13positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.83007567
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.71627268
15negative regulation of cell killing (GO:0031342)4.71627268
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.66431624
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.66431624
18negative regulation of viral genome replication (GO:0045071)4.61140502
19interferon-gamma-mediated signaling pathway (GO:0060333)4.47137761
20response to peptidoglycan (GO:0032494)4.39997364
21antigen processing and presentation of endogenous antigen (GO:0019883)4.37239859
22neutrophil activation involved in immune response (GO:0002283)4.37103199
23lipopolysaccharide-mediated signaling pathway (GO:0031663)4.23304055
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.19815173
25positive regulation by organism of defense response of other organism involved in symbiotic interact4.19815173
26modulation by symbiont of host immune response (GO:0052553)4.19815173
27positive regulation by symbiont of host defense response (GO:0052509)4.19815173
28modulation by symbiont of host defense response (GO:0052031)4.19815173
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.19815173
30regulation of interferon-beta biosynthetic process (GO:0045357)4.05293283
31positive regulation of interferon-beta production (GO:0032728)4.04215213
32regulation of type I interferon-mediated signaling pathway (GO:0060338)4.03931855
33detection of molecule of bacterial origin (GO:0032490)4.03035411
34cellular response to virus (GO:0098586)3.98098667
35negative regulation of interleukin-12 production (GO:0032695)3.96858172
36regulation of RIG-I signaling pathway (GO:0039535)3.95100224
37B cell mediated immunity (GO:0019724)3.92166182
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.85771435
39regulation of T-helper 1 cell differentiation (GO:0045625)3.79968222
40detection of other organism (GO:0098543)3.78028001
41detection of bacterium (GO:0016045)3.70232584
42detection of external biotic stimulus (GO:0098581)3.70087250
43microglial cell activation (GO:0001774)3.60555561
44regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.60000431
45defense response to protozoan (GO:0042832)3.59587312
46respiratory burst (GO:0045730)3.57293111
47T cell migration (GO:0072678)3.56809591
48regulation of dendritic cell antigen processing and presentation (GO:0002604)3.51850708
49positive regulation of gamma-delta T cell activation (GO:0046645)3.43350469
50positive regulation of chemokine biosynthetic process (GO:0045080)3.42732519
51positive regulation of type 2 immune response (GO:0002830)3.41487936
52cellular response to interferon-gamma (GO:0071346)3.38424112
53positive regulation of toll-like receptor signaling pathway (GO:0034123)3.38356314
54defense response to virus (GO:0051607)3.38036469
55regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.35825354
56response to exogenous dsRNA (GO:0043330)3.35798208
57response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.35655485
58response to host immune response (GO:0052572)3.35655485
59macrophage activation (GO:0042116)3.33500054
60antigen processing and presentation via MHC class Ib (GO:0002475)3.32666420
61negative regulation of cytokine production involved in immune response (GO:0002719)3.32411040
62regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.32327164
63regulation of antigen processing and presentation (GO:0002577)3.32213970
64T-helper 1 type immune response (GO:0042088)3.29965907
65regulation of chemokine biosynthetic process (GO:0045073)3.29522787
66leukocyte aggregation (GO:0070486)3.27156981
67negative regulation of myeloid cell apoptotic process (GO:0033033)3.26850044
68interferon-gamma secretion (GO:0072643)3.26671045
69response to protozoan (GO:0001562)3.23179816
70regulation of gamma-delta T cell activation (GO:0046643)3.22911046
71detection of biotic stimulus (GO:0009595)3.20270494
72regulation of B cell receptor signaling pathway (GO:0050855)3.19743240
73positive regulation of defense response to virus by host (GO:0002230)3.19343046
74NIK/NF-kappaB signaling (GO:0038061)3.18444511
75regulation of T cell tolerance induction (GO:0002664)3.12335384
76regulation of interleukin-12 biosynthetic process (GO:0045075)3.12089888
77regulation of response to interferon-gamma (GO:0060330)3.11930901
78response to interferon-gamma (GO:0034341)3.11332788
79lymphocyte chemotaxis (GO:0048247)3.10075997
80myeloid dendritic cell activation (GO:0001773)3.10048624
81positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.09211548
82positive regulation of natural killer cell differentiation (GO:0032825)3.08893981
83cellular response to zinc ion (GO:0071294)3.08315550
84regulation of defense response to virus by host (GO:0050691)3.07595737
85positive regulation of interleukin-17 production (GO:0032740)3.06330354
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.04597317
87macrophage activation involved in immune response (GO:0002281)3.04391399
88regulation of interleukin-17 production (GO:0032660)3.04033843
89positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.03332282
90negative regulation of interleukin-17 production (GO:0032700)3.02921187
91positive regulation of alpha-beta T cell proliferation (GO:0046641)3.02633970
92negative regulation of lymphocyte mediated immunity (GO:0002707)3.01859057
93granulocyte activation (GO:0036230)3.01789902
94regulation of T cell mediated cytotoxicity (GO:0001914)3.01458374
95negative regulation of innate immune response (GO:0045824)3.01209823
96negative regulation of T cell mediated immunity (GO:0002710)3.00996491
97positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.00869156
98mast cell activation (GO:0045576)3.00035807
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.99590821
100positive regulation of antigen processing and presentation (GO:0002579)2.99532113
101hydrogen peroxide biosynthetic process (GO:0050665)2.98350463
102myeloid cell activation involved in immune response (GO:0002275)2.97852397
103response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95087579
104response to host (GO:0075136)2.95087579
105response to host defenses (GO:0052200)2.95087579
106production of molecular mediator involved in inflammatory response (GO:0002532)2.94069161
107neutrophil activation (GO:0042119)2.93970751
108leukocyte migration involved in inflammatory response (GO:0002523)2.90785633
109regulation of alpha-beta T cell proliferation (GO:0046640)2.89398366
110JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.89243118
111response to muramyl dipeptide (GO:0032495)2.89239904
112regulation of type 2 immune response (GO:0002828)2.88939204
113regulation of tolerance induction (GO:0002643)2.88430261
114positive regulation of interleukin-12 production (GO:0032735)2.87069074
115positive regulation of T cell mediated cytotoxicity (GO:0001916)2.86889574
116positive regulation of NF-kappaB import into nucleus (GO:0042346)2.86581380
117regulation of activation of Janus kinase activity (GO:0010533)2.85852235
118cellular extravasation (GO:0045123)2.85337678
119negative regulation of viral process (GO:0048525)2.84977058
120negative regulation of leukocyte mediated immunity (GO:0002704)2.84672306
121regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.84587642
122regulation of interferon-beta production (GO:0032648)2.84319590
123germinal center formation (GO:0002467)2.84281725
124regulation of regulatory T cell differentiation (GO:0045589)2.83560577
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83298042
126positive regulation of isotype switching (GO:0045830)2.83272520
127interferon-gamma production (GO:0032609)2.82347706
128negative regulation of growth of symbiont in host (GO:0044130)2.81961355
129negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.81961355
130modulation of growth of symbiont involved in interaction with host (GO:0044144)2.81961355
131regulation of growth of symbiont in host (GO:0044126)2.81961355
132positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81501305
133positive regulation of lymphocyte migration (GO:2000403)2.78269634
134regulation of chronic inflammatory response (GO:0002676)2.77801220
135myeloid dendritic cell differentiation (GO:0043011)2.77455960
136cellular response to interleukin-15 (GO:0071350)2.76892116
137regulation of viral genome replication (GO:0045069)2.76493958
138positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.76402671
139positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.74980410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human8.20062370
2* IRF8_21731497_ChIP-ChIP_J774_Mouse6.56347142
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.11750735
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.58619536
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.21119416
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.68076704
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.72242273
8STAT4_19710469_ChIP-ChIP_TH1__Mouse3.34340585
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28549225
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.28423275
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.24166413
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20640349
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.02022126
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.99706119
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.73591860
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.56056987
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.29244765
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.29029343
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21624858
20MYB_26560356_Chip-Seq_TH2_Human2.08523758
21SPI1_23547873_ChIP-Seq_NB4_Human2.07007171
22SCL_19346495_ChIP-Seq_HPC-7_Human2.02180976
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96316133
24GATA1_22025678_ChIP-Seq_K562_Human1.94033325
25RUNX_20019798_ChIP-Seq_JUKART_Human1.80950122
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77494676
27MAF_26560356_Chip-Seq_TH1_Human1.77417348
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.76102877
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75864890
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.63335508
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62869766
32MYB_26560356_Chip-Seq_TH1_Human1.61849655
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60674913
34CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58148292
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.54714415
36VDR_24763502_ChIP-Seq_THP-1_Human1.53021459
37CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52267733
38* PU_27001747_Chip-Seq_BMDM_Mouse1.51609396
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50288128
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47938192
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39350109
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37539740
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.36051260
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35965494
45CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30599398
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30484906
47GATA3_26560356_Chip-Seq_TH2_Human1.29859022
48SPI1_23127762_ChIP-Seq_K562_Human1.25763649
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25414923
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25080361
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.23740937
52GATA3_27048872_Chip-Seq_THYMUS_Human1.22780412
53CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22321259
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20424816
55UTX_26944678_Chip-Seq_JUKART_Human1.19144889
56EGR1_19032775_ChIP-ChIP_M12_Human1.18875025
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17061006
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15428758
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14234589
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13730552
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07447219
62VDR_21846776_ChIP-Seq_THP-1_Human1.06108777
63STAT1_20625510_ChIP-Seq_HELA_Human1.04882643
64TCF7_22412390_ChIP-Seq_EML_Mouse1.04680371
65MAF_26560356_Chip-Seq_TH2_Human1.02704243
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00670998
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00356626
68MYC_22102868_ChIP-Seq_BL_Human0.98433252
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97545731
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96796787
71LXR_22292898_ChIP-Seq_THP-1_Human0.96740868
72VDR_24787735_ChIP-Seq_THP-1_Human0.96284562
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95526159
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92754128
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92608699
76NOTCH1_21737748_ChIP-Seq_TLL_Human0.92405116
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91436216
78BCOR_27268052_Chip-Seq_Bcells_Human0.91308457
79PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90168810
80KDM2B_26808549_Chip-Seq_DND41_Human0.89781421
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89405130
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89005896
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88960257
84GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88415696
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86879815
86SOX2_20726797_ChIP-Seq_SW620_Human0.85563788
87ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85175413
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.81385868
89TP63_17297297_ChIP-ChIP_HaCaT_Human0.79488726
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78808478
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.77243125
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.76940768
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.76434843
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76124056
95RXR_22158963_ChIP-Seq_LIVER_Mouse0.75446342
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74637217
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.74603508
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74551656
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74544152
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.73876612
101GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73554556
102GATA1_19941827_ChIP-Seq_MEL_Mouse0.72832852
103SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.71734304
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71310739
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.70794188
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.70783648
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70734802
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.70095200
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.69437048
110CTCF_26484167_Chip-Seq_Bcells_Mouse0.66010146
111* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.64864245
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.63240242
113SPI1_20517297_ChIP-Seq_HL60_Human0.61578716
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.61132247
115* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.58263112
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.56737624
117CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.55243447
118* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.52733553
119GATA1_19941826_ChIP-Seq_K562_Human0.52050980
120* BCL6_27268052_Chip-Seq_Bcells_Human0.50005889

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.03106560
2MP0009785_altered_susceptibility_to4.71847177
3MP0003724_increased_susceptibility_to4.42495139
4MP0006082_CNS_inflammation3.56315253
5MP0002148_abnormal_hypersensitivity_rea3.50526577
6MP0005025_abnormal_response_to3.41404158
7MP0005671_abnormal_response_to3.40894517
8MP0003436_decreased_susceptibility_to3.31548526
9MP0005000_abnormal_immune_tolerance3.21059026
10MP0000685_abnormal_immune_system3.19575353
11MP0002419_abnormal_innate_immunity2.93424930
12MP0001790_abnormal_immune_system2.85021766
13MP0005387_immune_system_phenotype2.85021766
14MP0002723_abnormal_immune_serum2.73337272
15MP0002006_tumorigenesis2.71807052
16MP0001800_abnormal_humoral_immune2.69122960
17MP0002166_altered_tumor_susceptibility2.68688321
18MP0002452_abnormal_antigen_presenting2.61453568
19MP0001819_abnormal_immune_cell2.36443626
20MP0002420_abnormal_adaptive_immunity2.33800087
21MP0004510_myositis2.20945408
22MP0004947_skin_inflammation2.07383784
23MP0001853_heart_inflammation2.04771317
24MP0009764_decreased_sensitivity_to2.02166238
25MP0001533_abnormal_skeleton_physiology1.99197532
26MP0008469_abnormal_protein_level1.97541694
27MP0002405_respiratory_system_inflammati1.95684987
28MP0001845_abnormal_inflammatory_respons1.93866163
29MP0005464_abnormal_platelet_physiology1.93136808
30MP0003303_peritoneal_inflammation1.92109018
31MP0010155_abnormal_intestine_physiology1.92102260
32MP0000343_altered_response_to1.87508964
33MP0000716_abnormal_immune_system1.79208442
34MP0002398_abnormal_bone_marrow1.76663036
35MP0003806_abnormal_nucleotide_metabolis1.75879332
36MP0003763_abnormal_thymus_physiology1.73446738
37MP0009333_abnormal_splenocyte_physiolog1.63753288
38MP0005058_abnormal_lysosome_morphology1.61669423
39MP0003191_abnormal_cellular_cholesterol1.54626859
40MP0003186_abnormal_redox_activity1.48760869
41MP0003448_altered_tumor_morphology1.47484869
42MP0002429_abnormal_blood_cell1.44866616
43MP0002139_abnormal_hepatobiliary_system1.43550169
44MP0000689_abnormal_spleen_morphology1.43093225
45MP0005310_abnormal_salivary_gland1.42392185
46MP0002722_abnormal_immune_system1.37234365
47MP0002998_abnormal_bone_remodeling1.36595830
48MP0005397_hematopoietic_system_phenotyp1.36249895
49MP0001545_abnormal_hematopoietic_system1.36249895
50MP0000858_altered_metastatic_potential1.35021898
51MP0003075_altered_response_to1.30982473
52MP0009278_abnormal_bone_marrow1.26650004
53MP0003183_abnormal_peptide_metabolism1.24131881
54MP0005451_abnormal_body_composition1.21611385
55MP0009763_increased_sensitivity_to1.16597695
56MP0002396_abnormal_hematopoietic_system1.11576715
57MP0002933_joint_inflammation1.10782784
58MP0005167_abnormal_blood-brain_barrier1.07893181
59MP0001851_eye_inflammation1.06608342
60MP0005166_decreased_susceptibility_to1.04108068
61MP0009840_abnormal_foam_cell0.99948463
62MP0008260_abnormal_autophagy0.99600551
63MP0008004_abnormal_stomach_pH0.98321700
64MP0003828_pulmonary_edema0.95954678
65MP0002254_reproductive_system_inflammat0.95657790
66MP0004782_abnormal_surfactant_physiolog0.95530003
67MP0005164_abnormal_response_to0.94409019
68MP0005390_skeleton_phenotype0.91008526
69MP0004808_abnormal_hematopoietic_stem0.88887295
70MP0000465_gastrointestinal_hemorrhage0.88812877
71MP0001873_stomach_inflammation0.88483214
72MP0003172_abnormal_lysosome_physiology0.87575726
73MP0002138_abnormal_hepatobiliary_system0.83285976
74MP0000249_abnormal_blood_vessel0.78850172
75MP0002277_abnormal_respiratory_mucosa0.78777495
76MP0000703_abnormal_thymus_morphology0.77875552
77MP0003866_abnormal_defecation0.76110920
78MP0002332_abnormal_exercise_endurance0.76099749
79MP0000604_amyloidosis0.72793555
80MP0003300_gastrointestinal_ulcer0.71181420
81MP0005075_abnormal_melanosome_morpholog0.66593123
82MP0008874_decreased_physiological_sensi0.66540143
83MP0005023_abnormal_wound_healing0.66409471
84MP0003195_calcinosis0.66341418
85MP0005174_abnormal_tail_pigmentation0.63888627
86MP0000490_abnormal_crypts_of0.62770937
87MP0002132_abnormal_respiratory_system0.62540469
88MP0009765_abnormal_xenobiotic_induced0.61800320
89MP0003690_abnormal_glial_cell0.61112573
90MP0002136_abnormal_kidney_physiology0.59895667
91MP0001542_abnormal_bone_strength0.59823430
92MP0003453_abnormal_keratinocyte_physiol0.59302472
93MP0005319_abnormal_enzyme/_coenzyme0.58826441
94MP0001879_abnormal_lymphatic_vessel0.58616424
95MP0004381_abnormal_hair_follicle0.56550599
96MP0003795_abnormal_bone_structure0.56288868
97MP0002019_abnormal_tumor_incidence0.54829244
98MP0000015_abnormal_ear_pigmentation0.54793798
99MP0010368_abnormal_lymphatic_system0.54473659
100MP0002693_abnormal_pancreas_physiology0.54178836
101MP0001348_abnormal_lacrimal_gland0.54108101
102MP0000609_abnormal_liver_physiology0.53831392
103MP0003656_abnormal_erythrocyte_physiolo0.50714914
104MP0003045_fibrosis0.49582991
105MP0001881_abnormal_mammary_gland0.48797331
106MP0000920_abnormal_myelination0.48255907
107MP0005584_abnormal_enzyme/coenzyme_acti0.48078311
108MP0005165_increased_susceptibility_to0.47966724
109MP0006054_spinal_hemorrhage0.47623761
110MP0001191_abnormal_skin_condition0.47233411
111MP0008873_increased_physiological_sensi0.46956973
112MP0001663_abnormal_digestive_system0.46814809
113MP0004883_abnormal_blood_vessel0.46746431

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.44381598
2Eczematoid dermatitis (HP:0000976)5.91753591
3Recurrent abscess formation (HP:0002722)5.90006456
4Recurrent bacterial skin infections (HP:0005406)5.33924395
5Myositis (HP:0100614)4.86819290
6Recurrent cutaneous fungal infections (HP:0011370)4.69863353
7Chronic mucocutaneous candidiasis (HP:0002728)4.69863353
8Recurrent gram-negative bacterial infections (HP:0005420)4.63859643
9Increased IgM level (HP:0003496)4.60562320
10Recurrent skin infections (HP:0001581)4.45689736
11Autoimmune thrombocytopenia (HP:0001973)4.44491683
12Abnormality of macrophages (HP:0004311)4.27129567
13Recurrent fungal infections (HP:0002841)4.25057445
14Orchitis (HP:0100796)4.12168343
15Chronic otitis media (HP:0000389)3.95132358
16Abnormality of glycolipid metabolism (HP:0010969)3.82568896
17Abnormality of liposaccharide metabolism (HP:0010968)3.82568896
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.82568896
19Retrobulbar optic neuritis (HP:0100654)3.78740844
20Optic neuritis (HP:0100653)3.78740844
21Basal ganglia calcification (HP:0002135)3.77948529
22Mediastinal lymphadenopathy (HP:0100721)3.76050158
23Systemic lupus erythematosus (HP:0002725)3.74072311
24Vasculitis (HP:0002633)3.63897154
25Recurrent viral infections (HP:0004429)3.63112337
26Vacuolated lymphocytes (HP:0001922)3.58273348
27Stomatitis (HP:0010280)3.56032750
28Recurrent bronchitis (HP:0002837)3.52072009
29Autoimmune hemolytic anemia (HP:0001890)3.46151706
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.43376226
31Hypergammaglobulinemia (HP:0010702)3.39496536
32Severe combined immunodeficiency (HP:0004430)3.25788406
33Thyroiditis (HP:0100646)3.24615998
34Increased IgE level (HP:0003212)3.13481447
35Loss of speech (HP:0002371)3.09292084
36Abnormality of T cell number (HP:0011839)3.08899554
37Interstitial pulmonary disease (HP:0006530)3.06172761
38Increased neuronal autofluorescent lipopigment (HP:0002074)3.04568530
39Combined immunodeficiency (HP:0005387)3.03937029
40IgG deficiency (HP:0004315)3.02617422
41Hemoptysis (HP:0002105)3.01084771
42Pustule (HP:0200039)3.00764367
43Gingivitis (HP:0000230)2.96877161
44Increased cerebral lipofuscin (HP:0011813)2.86550854
45Chronic obstructive pulmonary disease (HP:0006510)2.84413495
46Obstructive lung disease (HP:0006536)2.84413495
47T lymphocytopenia (HP:0005403)2.84172252
48Abnormality of T cells (HP:0002843)2.81230457
49Abnormality of the nasal mucosa (HP:0000433)2.79940558
50Leukocytosis (HP:0001974)2.78472367
51Nasal polyposis (HP:0100582)2.73474749
52Petechiae (HP:0000967)2.72724286
53Cheilitis (HP:0100825)2.69594439
54Hypoplasia of the thymus (HP:0000778)2.69411221
55Abnormality of eosinophils (HP:0001879)2.61150390
56Abnormality of T cell physiology (HP:0011840)2.60701326
57Pulmonary infiltrates (HP:0002113)2.59704755
58Meningitis (HP:0001287)2.59475832
59Chronic diarrhea (HP:0002028)2.59364567
60Thrombocytosis (HP:0001894)2.57947859
61Periodontitis (HP:0000704)2.57221931
62Abnormality of the pleura (HP:0002103)2.51631620
63Purpura (HP:0000979)2.50690361
64Prostate neoplasm (HP:0100787)2.50438770
65Cellulitis (HP:0100658)2.49497251
66Gingival bleeding (HP:0000225)2.48793184
67IgM deficiency (HP:0002850)2.46120136
68Pulmonary embolism (HP:0002204)2.43492894
69Urticaria (HP:0001025)2.42768593
70Hepatosplenomegaly (HP:0001433)2.42598967
71Increased serum ferritin (HP:0003281)2.37822439
72Arterial thrombosis (HP:0004420)2.37773153
73Dysostosis multiplex (HP:0000943)2.36288432
74Keratoconjunctivitis sicca (HP:0001097)2.34902250
75Recurrent pneumonia (HP:0006532)2.34504908
76Gastrointestinal infarctions (HP:0005244)2.32317165
77Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.32192256
78Episodic fever (HP:0001954)2.30360700
79Abnormality of the prostate (HP:0008775)2.30358688
80Lymphopenia (HP:0001888)2.28606751
81Inflammation of the large intestine (HP:0002037)2.28320663
82Gastrointestinal inflammation (HP:0004386)2.27965692
83Joint swelling (HP:0001386)2.27703514
84Abnormality of cells of the lymphoid lineage (HP:0012140)2.27263404
85Axonal loss (HP:0003447)2.25547003
86Tetraparesis (HP:0002273)2.25357721
87Agammaglobulinemia (HP:0004432)2.25154491
88Eosinophilia (HP:0001880)2.21882862
89Chest pain (HP:0100749)2.18634067
90Epistaxis (HP:0000421)2.18471005
91Poor head control (HP:0002421)2.17753188
92Amyloidosis (HP:0011034)2.17611681
93Recurrent lower respiratory tract infections (HP:0002783)2.16498923
94Glomerulonephritis (HP:0000099)2.14663015
95Keratoconjunctivitis (HP:0001096)2.13797120
96Keratitis (HP:0000491)2.12856293
97IgA deficiency (HP:0002720)2.12343358
98Panhypogammaglobulinemia (HP:0003139)2.12098873
99Spontaneous hematomas (HP:0007420)2.11802516
100Porencephaly (HP:0002132)2.11327410
101Anorexia (HP:0002039)2.09600359
102Abnormality of iron homeostasis (HP:0011031)2.07979727
103Progressive neurologic deterioration (HP:0002344)2.07534704
104Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.06959041
105Vertigo (HP:0002321)2.06219862
106Chronic sinusitis (HP:0011109)2.05609291
107Prolonged bleeding time (HP:0003010)2.05212997
108Joint hemorrhage (HP:0005261)2.04074993
109Disinhibition (HP:0000734)2.03156247
110Polyneuropathy (HP:0001271)2.02871884
111Abnormality of the pericardium (HP:0001697)2.02795337
112Encephalitis (HP:0002383)2.01172975
113Skin ulcer (HP:0200042)1.99665877
114Acne (HP:0001061)1.99651414
115Osteomyelitis (HP:0002754)1.99609196
116Glomerulopathy (HP:0100820)1.98477406
117Colitis (HP:0002583)1.98342640
118Arthralgia (HP:0002829)1.97688821
119Abnormality of B cell number (HP:0010975)1.97235675
120B lymphocytopenia (HP:0010976)1.97235675
121Skin rash (HP:0000988)1.97040402
122Granulocytopenia (HP:0001913)1.96932607
123Gangrene (HP:0100758)1.96677650
124Gastrointestinal stroma tumor (HP:0100723)1.96486045
125Thick nail (HP:0001805)1.95134883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IKBKE4.45127754
2KIT4.42898857
3TBK14.08986303
4TYK23.99286855
5FGFR43.76727861
6TXK3.64473034
7JAK33.44993520
8MAP3K143.24745768
9MAP4K13.09955721
10BLK2.59378834
11IRAK42.50835157
12JAK12.45999203
13PBK2.45527614
14RIPK42.16885842
15FGFR32.03236101
16IKBKB1.89264054
17ZAP701.86328945
18ERN11.81044599
19MAP3K31.73545204
20TEC1.69012052
21NME21.67443074
22KDR1.64354488
23PIM21.63831732
24TNK21.58141511
25CSF1R1.55316486
26FLT31.50498992
27MAP3K111.47536341
28TAOK21.45413010
29BTK1.41525790
30TAOK11.37821160
31ADRBK21.35537825
32SYK1.34975446
33MST41.34410297
34IRAK31.33243714
35PRPF4B1.32889183
36LCK1.31963621
37TGFBR21.25712841
38TIE11.20700068
39CSK1.19170321
40LYN1.19126447
41TLK11.15938845
42HCK1.15517551
43MAP3K131.12259007
44MAP3K121.07110473
45ACVR1B1.02113067
46CHUK1.00784742
47MATK0.97894433
48DDR20.96776285
49JAK20.88227323
50MAPK110.87811339
51EIF2AK20.87548791
52BCKDK0.86171591
53HIPK20.85374278
54TAOK30.84345163
55TGFBR10.83938247
56NEK90.82068658
57EPHB10.81958461
58NLK0.81484047
59ITK0.75114839
60BMPR20.73056669
61FES0.69968874
62RPS6KA40.69724058
63CDC42BPA0.66919739
64PRKCD0.66507928
65PIM10.62473224
66ABL20.61860508
67MAPKAPK30.56767225
68IRAK10.56145295
69MAP2K60.55829436
70RPS6KA50.55436910
71TNIK0.54676086
72MAPK70.53812984
73MYLK0.53701843
74TRPM70.52431082
75ABL10.50820113
76CAMKK20.50525335
77EPHA30.49652131
78STK100.48886416
79EGFR0.47573791
80PRKG20.47497606
81TESK20.46736281
82FGR0.45921550
83LRRK20.44131551
84GRK70.42874900
85MUSK0.42369028
86STK40.41337536
87CLK10.40749154
88PKN10.40621123
89RIPK10.40378504
90BMPR1B0.40193225
91MST1R0.38378660
92YES10.37288599
93PRKCQ0.37111682
94IGF1R0.35780817
95ARAF0.34923504
96MAP2K30.34138036
97PRKCH0.33350121
98GRK50.32674875
99CAMKK10.32557779
100MAP3K60.31200516
101PTK60.30725324
102BMX0.30110110
103TESK10.29789139
104GRK60.28556810
105STK160.28519778
106MOS0.27977264
107DAPK30.25814091
108PRKD10.24988562
109MARK20.24664530
110PDPK10.24540832
111PDK10.23596102
112FYN0.23578760
113EIF2AK10.22155723
114MAP3K10.21139398
115MAP3K20.20714998
116DAPK20.20271196
117IRAK20.19937984
118MAPKAPK20.19637462
119INSR0.19499682
120ERBB30.18595629
121PIK3CG0.17769370
122MAPK40.15958241
123MARK30.15803498
124MAPK30.15662422
125SIK30.15326077
126MAP3K50.14065523

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.69714702
2Graft-versus-host disease_Homo sapiens_hsa053323.26093827
3Leishmaniasis_Homo sapiens_hsa051403.20111365
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.04458644
5Allograft rejection_Homo sapiens_hsa053302.99660523
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.99267016
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.86139114
8Staphylococcus aureus infection_Homo sapiens_hsa051502.82263568
9Measles_Homo sapiens_hsa051622.80546914
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.63445954
11Primary immunodeficiency_Homo sapiens_hsa053402.61098584
12Legionellosis_Homo sapiens_hsa051342.38928009
13Malaria_Homo sapiens_hsa051442.35421590
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.33735635
15Herpes simplex infection_Homo sapiens_hsa051682.14586156
16Pertussis_Homo sapiens_hsa051332.11053886
17Influenza A_Homo sapiens_hsa051642.09016988
18NOD-like receptor signaling pathway_Homo sapiens_hsa046212.03881324
19Osteoclast differentiation_Homo sapiens_hsa043801.98737708
20Asthma_Homo sapiens_hsa053101.92914785
21Rheumatoid arthritis_Homo sapiens_hsa053231.91651519
22Hematopoietic cell lineage_Homo sapiens_hsa046401.81885924
23Type I diabetes mellitus_Homo sapiens_hsa049401.81317163
24Antigen processing and presentation_Homo sapiens_hsa046121.79747415
25Tuberculosis_Homo sapiens_hsa051521.73539919
26African trypanosomiasis_Homo sapiens_hsa051431.72201706
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.71603224
28Caffeine metabolism_Homo sapiens_hsa002321.70233318
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65979352
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.58635372
31TNF signaling pathway_Homo sapiens_hsa046681.56648657
32Salmonella infection_Homo sapiens_hsa051321.54934051
33Toxoplasmosis_Homo sapiens_hsa051451.51938947
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41105127
35Autoimmune thyroid disease_Homo sapiens_hsa053201.40542493
36Hepatitis C_Homo sapiens_hsa051601.31935607
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25483037
38Viral myocarditis_Homo sapiens_hsa054161.19835560
39Chemokine signaling pathway_Homo sapiens_hsa040621.19282626
40Lysosome_Homo sapiens_hsa041421.18587057
41B cell receptor signaling pathway_Homo sapiens_hsa046621.16028126
42Hepatitis B_Homo sapiens_hsa051611.10270154
43Shigellosis_Homo sapiens_hsa051311.09960015
44Proteasome_Homo sapiens_hsa030501.03065772
45Phagosome_Homo sapiens_hsa041451.02139565
46Apoptosis_Homo sapiens_hsa042101.01857312
47Other glycan degradation_Homo sapiens_hsa005110.91579743
48T cell receptor signaling pathway_Homo sapiens_hsa046600.91498206
49Complement and coagulation cascades_Homo sapiens_hsa046100.86831165
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77686231
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77500402
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.75849459
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.73516566
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71153113
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67033793
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66564049
57Prion diseases_Homo sapiens_hsa050200.52986012
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52465184
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52434422
60Amoebiasis_Homo sapiens_hsa051460.51932234
61Prolactin signaling pathway_Homo sapiens_hsa049170.50732064
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48967219
63Platelet activation_Homo sapiens_hsa046110.46435594
64Sulfur metabolism_Homo sapiens_hsa009200.45569952
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44769774
66Folate biosynthesis_Homo sapiens_hsa007900.44443144
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40482459
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40288244
69Epstein-Barr virus infection_Homo sapiens_hsa051690.40227866
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39577227
71Collecting duct acid secretion_Homo sapiens_hsa049660.38940416
72Ribosome_Homo sapiens_hsa030100.37779606
73Acute myeloid leukemia_Homo sapiens_hsa052210.37352620
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34995874
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.33053404
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32764679
77Pancreatic cancer_Homo sapiens_hsa052120.31568567
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.31294939
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30878484
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28637227
81Viral carcinogenesis_Homo sapiens_hsa052030.27805308
82Notch signaling pathway_Homo sapiens_hsa043300.25528869
83Endocytosis_Homo sapiens_hsa041440.24885388
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23250632
85VEGF signaling pathway_Homo sapiens_hsa043700.22840569
86Peroxisome_Homo sapiens_hsa041460.22332972
87Protein export_Homo sapiens_hsa030600.21660922
88ABC transporters_Homo sapiens_hsa020100.20680126
89Type II diabetes mellitus_Homo sapiens_hsa049300.20548308
90Histidine metabolism_Homo sapiens_hsa003400.18966127
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.18434100
92Chemical carcinogenesis_Homo sapiens_hsa052040.17886318
93Galactose metabolism_Homo sapiens_hsa000520.17672076
94Chronic myeloid leukemia_Homo sapiens_hsa052200.17533317
95Sulfur relay system_Homo sapiens_hsa041220.16796464
96HIF-1 signaling pathway_Homo sapiens_hsa040660.16267195
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16195750
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15756652
99Dorso-ventral axis formation_Homo sapiens_hsa043200.15572158
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14640324
101HTLV-I infection_Homo sapiens_hsa051660.13945953
102Pentose phosphate pathway_Homo sapiens_hsa000300.13414592
103FoxO signaling pathway_Homo sapiens_hsa040680.13242386
104Insulin resistance_Homo sapiens_hsa049310.12885504
105Mineral absorption_Homo sapiens_hsa049780.12292848
106Bladder cancer_Homo sapiens_hsa052190.10042817
107Steroid biosynthesis_Homo sapiens_hsa001000.08833975
108Sphingolipid metabolism_Homo sapiens_hsa006000.08813090
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.08781202
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.08176825
111Vitamin digestion and absorption_Homo sapiens_hsa049770.06837924
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.06779440
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06744673
114Renin-angiotensin system_Homo sapiens_hsa046140.06585028
115Arachidonic acid metabolism_Homo sapiens_hsa005900.05555257
116Pyrimidine metabolism_Homo sapiens_hsa002400.04693053
117p53 signaling pathway_Homo sapiens_hsa041150.04442184
118Systemic lupus erythematosus_Homo sapiens_hsa053220.04072849
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.03542827
120Non-small cell lung cancer_Homo sapiens_hsa052230.03363225

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