RTN4RL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.09746316
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.74666985
3locomotory exploration behavior (GO:0035641)6.21888296
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.97325523
5glutamate secretion (GO:0014047)5.90322396
6synaptic vesicle exocytosis (GO:0016079)5.82990208
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.75612620
8protein localization to synapse (GO:0035418)5.66204439
9vocalization behavior (GO:0071625)5.61633305
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.58710244
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.52483490
12regulation of synaptic vesicle exocytosis (GO:2000300)5.25429789
13exploration behavior (GO:0035640)5.19293737
14layer formation in cerebral cortex (GO:0021819)5.17354606
15regulation of glutamate receptor signaling pathway (GO:1900449)5.11625265
16cellular potassium ion homeostasis (GO:0030007)4.72079536
17regulation of neuronal synaptic plasticity (GO:0048168)4.67039394
18regulation of synaptic vesicle transport (GO:1902803)4.61423426
19sodium ion export (GO:0071436)4.56533388
20dendritic spine morphogenesis (GO:0060997)4.53032800
21neuron cell-cell adhesion (GO:0007158)4.48614896
22positive regulation of synapse maturation (GO:0090129)4.46772433
23L-phenylalanine catabolic process (GO:0006559)4.42587841
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.42587841
25L-phenylalanine metabolic process (GO:0006558)4.40760633
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.40760633
27regulation of synapse structural plasticity (GO:0051823)4.39890682
28proline transport (GO:0015824)4.37642293
29regulation of long-term neuronal synaptic plasticity (GO:0048169)4.36677742
30neurotransmitter-gated ion channel clustering (GO:0072578)4.24355444
31ionotropic glutamate receptor signaling pathway (GO:0035235)4.18665556
32neurotransmitter secretion (GO:0007269)4.17035138
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.08209269
34cell communication by electrical coupling (GO:0010644)3.99631750
35synaptic transmission, glutamatergic (GO:0035249)3.94235854
36innervation (GO:0060384)3.89435315
37positive regulation of membrane potential (GO:0045838)3.88628929
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87834065
39glutamate receptor signaling pathway (GO:0007215)3.82509761
40neuronal ion channel clustering (GO:0045161)3.80318645
41regulation of dendritic spine morphogenesis (GO:0061001)3.75652300
42neuronal action potential propagation (GO:0019227)3.74389754
43positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.73132697
44long-term memory (GO:0007616)3.69934393
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67414423
46central nervous system myelination (GO:0022010)3.67217268
47axon ensheathment in central nervous system (GO:0032291)3.67217268
48G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.67158525
49activation of protein kinase A activity (GO:0034199)3.66345841
50regulation of synaptic plasticity (GO:0048167)3.66078790
51cell-cell junction maintenance (GO:0045217)3.65703859
52synaptic vesicle endocytosis (GO:0048488)3.62635492
53positive regulation of neurotransmitter transport (GO:0051590)3.59691071
54cerebellar granule cell differentiation (GO:0021707)3.55849583
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.53416239
56neuromuscular process controlling balance (GO:0050885)3.51326562
57dendrite morphogenesis (GO:0048813)3.49949581
58amino acid import (GO:0043090)3.49383888
59cell migration in hindbrain (GO:0021535)3.48870622
60postsynaptic membrane organization (GO:0001941)3.48387515
61regulation of ARF protein signal transduction (GO:0032012)3.48039650
62neuron-neuron synaptic transmission (GO:0007270)3.47248407
63regulation of neurotransmitter secretion (GO:0046928)3.46851190
64regulation of postsynaptic membrane potential (GO:0060078)3.46521330
65dendritic spine organization (GO:0097061)3.46414353
66neuron recognition (GO:0008038)3.41145661
67positive regulation of dendritic spine development (GO:0060999)3.39432087
68regulation of vesicle fusion (GO:0031338)3.28499895
69long-term synaptic potentiation (GO:0060291)3.25579638
70peptidyl-glutamic acid carboxylation (GO:0017187)3.24554401
71protein carboxylation (GO:0018214)3.24554401
72regulation of synapse maturation (GO:0090128)3.24468100
73membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.24352418
74neurotransmitter transport (GO:0006836)3.23281173
75L-serine metabolic process (GO:0006563)3.20075424
76cerebellar Purkinje cell layer development (GO:0021680)3.19898455
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.19703168
78cellular sodium ion homeostasis (GO:0006883)3.18366996
79axonal fasciculation (GO:0007413)3.17609708
80establishment of mitochondrion localization (GO:0051654)3.16802678
81gamma-aminobutyric acid signaling pathway (GO:0007214)3.16611810
82regulation of dendritic spine development (GO:0060998)3.16348882
83establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.16154972
84mitochondrion transport along microtubule (GO:0047497)3.16154972
85gamma-aminobutyric acid transport (GO:0015812)3.15965907
86neuromuscular process controlling posture (GO:0050884)3.15242241
87L-amino acid import (GO:0043092)3.13867929
88respiratory system process (GO:0003016)3.12514267
89regulation of neurotransmitter transport (GO:0051588)3.11272756
90phosphate ion transmembrane transport (GO:0035435)3.10818119
91dicarboxylic acid transport (GO:0006835)3.07616508
92regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06759269
93alanine transport (GO:0032328)3.06201868
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.02825156
95positive regulation of neurotransmitter secretion (GO:0001956)3.01174101
96positive regulation of fibroblast migration (GO:0010763)2.99920210
97behavioral fear response (GO:0001662)2.97135319
98behavioral defense response (GO:0002209)2.97135319
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96714430
100regulation of neurotransmitter levels (GO:0001505)2.96467054
101regulation of synaptic transmission, glutamatergic (GO:0051966)2.96288806
102potassium ion homeostasis (GO:0055075)2.94506865
103response to auditory stimulus (GO:0010996)2.93426474
104G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93363953
105regulation of synaptic transmission (GO:0050804)2.92647161
106clathrin coat assembly (GO:0048268)2.91746062
107skeletal muscle organ development (GO:0060538)2.91658982
108membrane depolarization (GO:0051899)2.91514377
109regulation of voltage-gated calcium channel activity (GO:1901385)2.91333751
110chemosensory behavior (GO:0007635)2.89294374
111axon cargo transport (GO:0008088)2.88088829
112synapse assembly (GO:0007416)2.87990748
113membrane depolarization during action potential (GO:0086010)2.87835788
114central nervous system projection neuron axonogenesis (GO:0021952)2.87150154
115cytoskeletal anchoring at plasma membrane (GO:0007016)2.86644617
116learning (GO:0007612)2.85807934
117intraspecies interaction between organisms (GO:0051703)2.84818040
118social behavior (GO:0035176)2.84818040
119auditory behavior (GO:0031223)2.84740431
120positive regulation of synaptic transmission, GABAergic (GO:0032230)2.83343305
121vesicle transport along microtubule (GO:0047496)2.83294466
122cerebellar Purkinje cell differentiation (GO:0021702)2.82679064
123glycine transport (GO:0015816)2.81755322
124suckling behavior (GO:0001967)2.80000069
125positive regulation of synaptic transmission (GO:0050806)2.79555831
126regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79150150
127organelle transport along microtubule (GO:0072384)2.78310559
128protein retention in ER lumen (GO:0006621)2.70238981
129ribosomal small subunit biogenesis (GO:0042274)2.66135666
130presynaptic membrane organization (GO:0097090)2.65725183
131L-alpha-amino acid transmembrane transport (GO:1902475)2.63022006
132negative regulation of cholesterol transport (GO:0032375)2.57646222
133negative regulation of sterol transport (GO:0032372)2.57646222
134diaphragm development (GO:0060539)2.57077824
135iron coordination entity transport (GO:1901678)2.55805278
136cell junction maintenance (GO:0034331)2.54162274
137serine family amino acid catabolic process (GO:0009071)2.53786819
138response to dietary excess (GO:0002021)2.50636631
139negative regulation of microtubule polymerization (GO:0031115)2.50210886
140regulation of NFAT protein import into nucleus (GO:0051532)2.47566542
141negative regulation of fibrinolysis (GO:0051918)2.47112084
142neuromuscular synaptic transmission (GO:0007274)2.45425084
143lung epithelium development (GO:0060428)2.44799125
144behavioral response to cocaine (GO:0048148)2.44722900
145acidic amino acid transport (GO:0015800)2.44109560
146proline metabolic process (GO:0006560)2.41804656
147regulation of fibrinolysis (GO:0051917)2.41621487
148mating behavior (GO:0007617)2.41472748
149phosphate ion transport (GO:0006817)2.41097317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.46227723
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.10823449
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16715425
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10411552
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03030289
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.89837608
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.89837608
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.85555213
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.77572578
10DROSHA_22980978_ChIP-Seq_HELA_Human2.75246746
11GBX2_23144817_ChIP-Seq_PC3_Human2.72546266
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.69755420
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63564646
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63324415
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61921836
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.60593163
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59237430
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.54681400
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.50002123
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.47242514
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.46047936
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38968335
23SRY_22984422_ChIP-ChIP_TESTIS_Rat2.37712090
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.36589074
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.35306946
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.24616538
27* EED_16625203_ChIP-ChIP_MESCs_Mouse2.22460335
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15627198
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14486606
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00755003
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92530339
32P68_20966046_ChIP-Seq_HELA_Human1.89103537
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.87372269
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79237621
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.77219041
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.74094267
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69715863
38AR_21572438_ChIP-Seq_LNCaP_Human1.67244619
39RACK7_27058665_Chip-Seq_MCF-7_Human1.65932274
40* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63833842
41* KDM2B_26808549_Chip-Seq_K562_Human1.61368520
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.60674932
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59632068
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58220188
45* RING1B_27294783_Chip-Seq_ESCs_Mouse1.57647236
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57138147
47SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51522432
48SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.50966631
49CREB1_26743006_Chip-Seq_LNCaP_Human1.50314083
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45332425
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43412966
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42753707
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.41303412
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39985925
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39239037
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38102335
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35541204
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.34924479
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34388248
60* SA1_27219007_Chip-Seq_ERYTHROID_Human1.34056153
61VDR_21846776_ChIP-Seq_THP-1_Human1.34041911
62* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33517421
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31992781
64* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.31941598
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31633599
66ZNF274_21170338_ChIP-Seq_K562_Hela1.31605955
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31288205
68* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30032137
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29748622
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28969124
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27934327
72* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.27045199
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26394514
74* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26082329
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.24982804
76SMAD4_21799915_ChIP-Seq_A2780_Human1.21568997
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21421747
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.21229867
79STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.20082770
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19493202
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18000347
82AR_19668381_ChIP-Seq_PC3_Human1.17268248
83* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17232184
84RARA_24833708_ChIP-Seq_LIVER_Mouse1.16359733
85* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15047551
86* SA1_27219007_Chip-Seq_Bcells_Human1.14162035
87LXR_22292898_ChIP-Seq_THP-1_Human1.13922206
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13351854
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12570633
90OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12358733
91MYC_22102868_ChIP-Seq_BL_Human1.11550931
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10903821
93* CTCF_27219007_Chip-Seq_Bcells_Human1.10810419
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08693388
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.08588743
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08284152
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08276258
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08191672
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07903247
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07833216
101OCT4_19829295_ChIP-Seq_ESCs_Human1.05800488
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03824004
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03509730
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03324984
105* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03000380
106XRN2_22483619_ChIP-Seq_HELA_Human1.02065136
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01967344
108TET1_21490601_ChIP-Seq_MESCs_Mouse1.01794457
109* AR_25329375_ChIP-Seq_VCAP_Human1.00821297
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00798122
111RXR_22158963_ChIP-Seq_LIVER_Mouse1.00589017
112JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00340202
113CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99709139
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99421512
115FOXP1_21924763_ChIP-Seq_HESCs_Human0.98176944
116YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97829306
117SMAD_19615063_ChIP-ChIP_OVARY_Human0.97168866
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.97084878
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96503329
120SMAD3_21741376_ChIP-Seq_EPCs_Human0.95904576
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95675073
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95158400
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.94299384
124* KDM2B_26808549_Chip-Seq_DND41_Human0.94102032
125* KDM2B_26808549_Chip-Seq_JURKAT_Human0.93675181
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.93005338
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92540260
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.89754614
129CBX2_27304074_Chip-Seq_ESCs_Mouse0.87393998
130STAT3_23295773_ChIP-Seq_U87_Human0.87363752
131TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85301236
132AHR_22903824_ChIP-Seq_MCF-7_Human0.84785585
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83280047
134SMC4_20622854_ChIP-Seq_HELA_Human0.83008302
135CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81521188
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81047808
137TP53_16413492_ChIP-PET_HCT116_Human0.80559771
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80197892
139P300_19829295_ChIP-Seq_ESCs_Human0.79915615
140ZNF263_19887448_ChIP-Seq_K562_Human0.79792627
141TCF4_23295773_ChIP-Seq_U87_Human0.76866828
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.76659731
143* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.75709174
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74840311
145RNF2_27304074_Chip-Seq_NSC_Mouse0.74466218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.70756762
2MP0003635_abnormal_synaptic_transmissio4.29409997
3MP0003880_abnormal_central_pattern4.04901445
4MP0004270_analgesia3.92408432
5MP0002063_abnormal_learning/memory/cond3.48230527
6MP0002139_abnormal_hepatobiliary_system3.29672920
7MP0009745_abnormal_behavioral_response3.15499843
8MP0004858_abnormal_nervous_system3.07672598
9MP0002064_seizures2.90912741
10MP0001968_abnormal_touch/_nociception2.79080895
11MP0005423_abnormal_somatic_nervous2.74869161
12MP0003123_paternal_imprinting2.70794260
13MP0002734_abnormal_mechanical_nocicepti2.62075094
14MP0002572_abnormal_emotion/affect_behav2.57061774
15MP0009780_abnormal_chondrocyte_physiolo2.50317077
16MP0001486_abnormal_startle_reflex2.38858008
17MP0009046_muscle_twitch2.34853861
18MP0003329_amyloid_beta_deposits2.33829144
19MP0002735_abnormal_chemical_nociception2.32118060
20MP0002272_abnormal_nervous_system2.19404701
21MP0002736_abnormal_nociception_after2.16752155
22MP0003879_abnormal_hair_cell2.05245896
23MP0004811_abnormal_neuron_physiology2.03116832
24MP0001440_abnormal_grooming_behavior1.99904601
25MP0000778_abnormal_nervous_system1.99880248
26MP0001501_abnormal_sleep_pattern1.96830889
27MP0002184_abnormal_innervation1.91325343
28MP0002733_abnormal_thermal_nociception1.90488616
29MP0002822_catalepsy1.81721136
30MP0001970_abnormal_pain_threshold1.81579569
31MP0008569_lethality_at_weaning1.79928430
32MP0000955_abnormal_spinal_cord1.67414432
33MP0005058_abnormal_lysosome_morphology1.65819522
34MP0002909_abnormal_adrenal_gland1.64010247
35MP0002067_abnormal_sensory_capabilities1.61721371
36MP0006292_abnormal_olfactory_placode1.56276719
37MP0002557_abnormal_social/conspecific_i1.55727236
38MP0002249_abnormal_larynx_morphology1.53811643
39MP0002882_abnormal_neuron_morphology1.53512570
40MP0004885_abnormal_endolymph1.52271881
41MP0001502_abnormal_circadian_rhythm1.50333085
42MP0000566_synostosis1.40352828
43MP0003075_altered_response_to1.39885435
44MP0009840_abnormal_foam_cell1.38388754
45MP0004233_abnormal_muscle_weight1.36652399
46MP0001188_hyperpigmentation1.36581613
47MP0005386_behavior/neurological_phenoty1.36300965
48MP0004924_abnormal_behavior1.36300965
49MP0008961_abnormal_basal_metabolism1.35733152
50MP0005551_abnormal_eye_electrophysiolog1.34213396
51MP0005360_urolithiasis1.33496336
52MP0002066_abnormal_motor_capabilities/c1.33159630
53MP0003633_abnormal_nervous_system1.31634014
54MP0005365_abnormal_bile_salt1.27661029
55MP0000751_myopathy1.24455740
56MP0001984_abnormal_olfaction1.23488299
57MP0010030_abnormal_orbit_morphology1.22366747
58MP0002090_abnormal_vision1.22238246
59MP0008875_abnormal_xenobiotic_pharmacok1.22223985
60MP0005623_abnormal_meninges_morphology1.20910454
61MP0001346_abnormal_lacrimal_gland1.18495816
62MP0000681_abnormal_thyroid_gland1.16006068
63MP0002152_abnormal_brain_morphology1.14985828
64MP0003938_abnormal_ear_development1.14319003
65MP0000604_amyloidosis1.12564854
66MP0003631_nervous_system_phenotype1.10490579
67MP0003787_abnormal_imprinting1.07038543
68MP0005645_abnormal_hypothalamus_physiol1.05000005
69MP0003136_yellow_coat_color1.04988736
70MP0004133_heterotaxia1.04396409
71MP0002653_abnormal_ependyma_morphology1.02176095
72MP0000678_abnormal_parathyroid_gland1.01724455
73MP0000569_abnormal_digit_pigmentation0.96465284
74MP0003121_genomic_imprinting0.96310345
75MP0004510_myositis0.95799983
76MP0002069_abnormal_eating/drinking_beha0.94622419
77MP0006276_abnormal_autonomic_nervous0.94434550
78MP0004019_abnormal_vitamin_homeostasis0.94246426
79MP0003690_abnormal_glial_cell0.94033942
80MP0010386_abnormal_urinary_bladder0.93274708
81MP0003634_abnormal_glial_cell0.92754421
82MP0002229_neurodegeneration0.90474362
83MP0003283_abnormal_digestive_organ0.90160770
84MP0004130_abnormal_muscle_cell0.89141374
85MP0005451_abnormal_body_composition0.87685688
86MP0006072_abnormal_retinal_apoptosis0.84582443
87MP0001177_atelectasis0.82951852
88MP0010234_abnormal_vibrissa_follicle0.82584922
89MP0009672_abnormal_birth_weight0.82419616
90MP0008874_decreased_physiological_sensi0.82410847
91MP0002752_abnormal_somatic_nervous0.82375783
92MP0002876_abnormal_thyroid_physiology0.82029495
93MP0008872_abnormal_physiological_respon0.81404889
94MP0000003_abnormal_adipose_tissue0.81180606
95MP0004215_abnormal_myocardial_fiber0.80837378
96MP0001348_abnormal_lacrimal_gland0.80713880
97MP0000049_abnormal_middle_ear0.80536498
98MP0001905_abnormal_dopamine_level0.79282381
99MP0004484_altered_response_of0.77382024
100MP0000026_abnormal_inner_ear0.77378501
101MP0002234_abnormal_pharynx_morphology0.76902452
102MP0004142_abnormal_muscle_tone0.76779756
103MP0003632_abnormal_nervous_system0.76170067
104MP0004085_abnormal_heartbeat0.76137631
105MP0001963_abnormal_hearing_physiology0.74117574
106MP0004145_abnormal_muscle_electrophysio0.74014320
107MP0003172_abnormal_lysosome_physiology0.70750190
108MP0005499_abnormal_olfactory_system0.69895684
109MP0005394_taste/olfaction_phenotype0.69895684
110MP0005076_abnormal_cell_differentiation0.69823052
111MP0005646_abnormal_pituitary_gland0.69730324
112MP0003137_abnormal_impulse_conducting0.69546914
113MP0000579_abnormal_nail_morphology0.69089922
114MP0002138_abnormal_hepatobiliary_system0.69003225
115MP0003861_abnormal_nervous_system0.68841467
116MP0000534_abnormal_ureter_morphology0.68105712
117MP0005167_abnormal_blood-brain_barrier0.67872421
118MP0003942_abnormal_urinary_system0.66075195
119MP0003122_maternal_imprinting0.66026018
120MP0002089_abnormal_postnatal_growth/wei0.65770049
121MP0001664_abnormal_digestion0.64688036
122MP0005535_abnormal_body_temperature0.64553614
123MP0000631_abnormal_neuroendocrine_gland0.62743360
124MP0009379_abnormal_foot_pigmentation0.61928270
125MP0003045_fibrosis0.61078811
126MP0005257_abnormal_intraocular_pressure0.60905404
127MP0009278_abnormal_bone_marrow0.60078643
128MP0005187_abnormal_penis_morphology0.59341311
129MP0005166_decreased_susceptibility_to0.58897060
130MP0005253_abnormal_eye_physiology0.58314561
131MP0002751_abnormal_autonomic_nervous0.57713968
132MP0000920_abnormal_myelination0.57401451
133MP0003646_muscle_fatigue0.55796198
134MP0004742_abnormal_vestibular_system0.55424959

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.09258129
2Focal motor seizures (HP:0011153)5.63194310
3Visual hallucinations (HP:0002367)5.48501372
4Focal seizures (HP:0007359)4.95482118
5Epileptic encephalopathy (HP:0200134)4.59698501
6Action tremor (HP:0002345)4.08383075
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.05723838
8Supranuclear gaze palsy (HP:0000605)4.01551162
9Mutism (HP:0002300)3.95819576
10Progressive cerebellar ataxia (HP:0002073)3.90750851
11Deep venous thrombosis (HP:0002625)3.85843059
12Febrile seizures (HP:0002373)3.73944340
13Absence seizures (HP:0002121)3.68820997
14Atonic seizures (HP:0010819)3.67354091
15Abnormality of the lower motor neuron (HP:0002366)3.55410917
16Ankle clonus (HP:0011448)3.51464265
17Generalized tonic-clonic seizures (HP:0002069)3.43472149
18Depression (HP:0000716)3.37125370
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.32120179
20Dialeptic seizures (HP:0011146)3.28022467
21Impaired vibration sensation in the lower limbs (HP:0002166)3.20933662
22Amblyopia (HP:0000646)3.18750867
23Poor eye contact (HP:0000817)3.16287858
24Papilledema (HP:0001085)3.13318612
25Cerebral inclusion bodies (HP:0100314)3.07003105
26Postural instability (HP:0002172)2.98321670
27Abnormality of the Achilles tendon (HP:0005109)2.97551621
28Turricephaly (HP:0000262)2.97511636
29Urinary bladder sphincter dysfunction (HP:0002839)2.96361374
30Neurofibrillary tangles (HP:0002185)2.94550811
31Torticollis (HP:0000473)2.93170596
32Genetic anticipation (HP:0003743)2.87212040
33Abnormal social behavior (HP:0012433)2.84748333
34Impaired social interactions (HP:0000735)2.84748333
35Ventricular fibrillation (HP:0001663)2.81871007
36Athetosis (HP:0002305)2.81192820
37Prolonged partial thromboplastin time (HP:0003645)2.78992989
38Insomnia (HP:0100785)2.78099002
39Dysdiadochokinesis (HP:0002075)2.76759891
40Dysmetria (HP:0001310)2.73089762
41Focal dystonia (HP:0004373)2.72701573
42Hyperthyroidism (HP:0000836)2.71884463
43Anxiety (HP:0000739)2.69635396
44Broad-based gait (HP:0002136)2.65330089
45Megalencephaly (HP:0001355)2.63027860
46Urinary urgency (HP:0000012)2.62240169
47Choanal stenosis (HP:0000452)2.60035971
48Excessive salivation (HP:0003781)2.59495548
49Drooling (HP:0002307)2.59495548
50Abnormal eating behavior (HP:0100738)2.57563946
51Termporal pattern (HP:0011008)2.55310645
52Insidious onset (HP:0003587)2.55310645
53Neuronal loss in central nervous system (HP:0002529)2.53605126
54Truncal ataxia (HP:0002078)2.52950697
55Hemiparesis (HP:0001269)2.51533142
56Abnormality of binocular vision (HP:0011514)2.47809455
57Diplopia (HP:0000651)2.47809455
58Overriding aorta (HP:0002623)2.46193386
59Bronchomalacia (HP:0002780)2.45223051
60Obstructive sleep apnea (HP:0002870)2.44493781
61Gaze-evoked nystagmus (HP:0000640)2.44220664
62Hemiplegia (HP:0002301)2.43759854
63Pointed chin (HP:0000307)2.40505498
64Spastic gait (HP:0002064)2.40477788
65Stereotypic behavior (HP:0000733)2.39507789
66Bradykinesia (HP:0002067)2.39258370
67Epileptiform EEG discharges (HP:0011182)2.39034409
68Central scotoma (HP:0000603)2.38002703
69Annular pancreas (HP:0001734)2.37591262
70Craniofacial dystonia (HP:0012179)2.36793184
71Impaired smooth pursuit (HP:0007772)2.34891705
72Intention tremor (HP:0002080)2.34807403
73Amyotrophic lateral sclerosis (HP:0007354)2.34165977
74Ulnar bowing (HP:0003031)2.33729095
75Aplasia of the phalanges of the hand (HP:0009802)2.33060083
76Aplasia involving bones of the extremities (HP:0009825)2.33060083
77Aplasia involving bones of the upper limbs (HP:0009823)2.33060083
78EEG with generalized epileptiform discharges (HP:0011198)2.32938751
79Hypoventilation (HP:0002791)2.29311545
80Pheochromocytoma (HP:0002666)2.28631238
81Abnormality of the corticospinal tract (HP:0002492)2.25976266
82Hypercortisolism (HP:0001578)2.23456052
83Apathy (HP:0000741)2.21964104
84Vaginal fistula (HP:0004320)2.21383354
85Bundle branch block (HP:0011710)2.18280882
86Synostosis involving the elbow (HP:0003938)2.16383089
87Humeroradial synostosis (HP:0003041)2.16383089
88Lower limb muscle weakness (HP:0007340)2.13839605
89Hypsarrhythmia (HP:0002521)2.10430916
90Status epilepticus (HP:0002133)2.08249795
91Abnormality of ocular smooth pursuit (HP:0000617)2.07628446
92Impaired vibratory sensation (HP:0002495)2.07499732
93Peripheral hypomyelination (HP:0007182)2.06661841
94Rapidly progressive (HP:0003678)2.05723404
95Nuclear cataract (HP:0100018)2.04949712
96Distal upper limb amyotrophy (HP:0007149)2.03840252
97Upper limb amyotrophy (HP:0009129)2.03840252
98Hyperacusis (HP:0010780)2.03236356
99Delusions (HP:0000746)2.02903658
100Agitation (HP:0000713)2.02671230
101Nasolacrimal duct obstruction (HP:0000579)2.01285301
102Fetal akinesia sequence (HP:0001989)1.98940565
103Intellectual disability, profound (HP:0002187)1.98847609
104Hand muscle atrophy (HP:0009130)1.98417909
105Lower limb amyotrophy (HP:0007210)1.97556993
106Dysphonia (HP:0001618)1.97418880
107Renal duplication (HP:0000075)1.96114749
108Generalized myoclonic seizures (HP:0002123)1.95650521
109Diminished motivation (HP:0000745)1.95039937
110Hypercholesterolemia (HP:0003124)1.93220039
111Congenital stationary night blindness (HP:0007642)1.93018057
112Neuroendocrine neoplasm (HP:0100634)1.92835423
113Akinesia (HP:0002304)1.92733784
114Hyperventilation (HP:0002883)1.92678826
115Joint hemorrhage (HP:0005261)1.92551614
116Dysmetric saccades (HP:0000641)1.91776495
117Incomplete penetrance (HP:0003829)1.90194312
118Neoplasm of the peripheral nervous system (HP:0100007)1.90163465
119Partial duplication of thumb phalanx (HP:0009944)1.88059646
120Systemic lupus erythematosus (HP:0002725)1.88042130
121Progressive inability to walk (HP:0002505)1.87797782
122Split foot (HP:0001839)1.86871599
123Long palpebral fissure (HP:0000637)1.86595303
124Clonus (HP:0002169)1.86438572
125Neonatal onset (HP:0003623)1.84108590
126Sleep apnea (HP:0010535)1.82755768
127Complement deficiency (HP:0004431)1.82413535
128Dementia (HP:0000726)1.82267453
129Absent speech (HP:0001344)1.82229665
130Rib fusion (HP:0000902)1.82021980
131Inappropriate behavior (HP:0000719)1.81135161
132Achilles tendon contracture (HP:0001771)1.81047063
133Large eyes (HP:0001090)1.80735409
134Lower limb asymmetry (HP:0100559)1.79916218
135Elfin facies (HP:0004428)1.79615838
136Polyphagia (HP:0002591)1.78570261
137Abnormality of macular pigmentation (HP:0008002)1.78280668
138Abnormality of the aortic arch (HP:0012303)1.78269688
139Abnormality of the lacrimal duct (HP:0011481)1.78120412
140Inability to walk (HP:0002540)1.77796620
141Cerebral hypomyelination (HP:0006808)1.77730142
142Renovascular hypertension (HP:0100817)1.77463106
143Abnormality of cochlea (HP:0000375)1.77296751
144Aqueductal stenosis (HP:0002410)1.76417705
145Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.75582556
146Multiple enchondromatosis (HP:0005701)1.71743582
147Coronal craniosynostosis (HP:0004440)1.66167232
148Retinal atrophy (HP:0001105)1.64812256
149Hyperparathyroidism (HP:0000843)1.63514718
150Thickened helices (HP:0000391)1.60889278
151Broad distal phalanx of finger (HP:0009836)1.60609866
152Xanthomatosis (HP:0000991)1.60587494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.41552717
2MARK13.85905771
3EPHA43.81598214
4NTRK33.71393675
5PAK63.06744526
6DAPK22.89710800
7MINK12.81646341
8PRKD32.81490060
9KSR22.62120692
10NME22.56773626
11MAP3K42.41432402
12NTRK12.21346093
13CAMKK12.18050851
14LATS21.86137143
15MAP3K111.85124290
16KSR11.83876203
17SIK11.82721476
18NTRK21.79162172
19ERN11.68345127
20MAP2K71.66781114
21DAPK11.60943629
22CDK51.57631479
23PRPF4B1.55003661
24PHKG11.49599735
25PHKG21.49599735
26PLK21.49426492
27IRAK31.45416328
28MAP2K41.40808842
29BRAF1.37529340
30EEF2K1.36139843
31TAOK11.35374692
32GRK51.31390615
33SIK21.30922286
34SMG11.30248053
35NEK11.29583194
36PDK21.26842252
37STK381.24271215
38ABL21.24009167
39CAMK11.23956732
40MAP3K21.22543427
41PRKCG1.16927006
42ALK1.15898341
43RET1.13589811
44TYRO31.13062721
45MAPK131.10964090
46ARAF1.10732158
47RIPK11.10015540
48CDK121.08555990
49CAMK1D1.04131376
50PAK31.03548563
51RIPK41.03249678
52MAP3K131.02588302
53CDK151.02364096
54CDK181.01233241
55UHMK10.99495074
56CDK140.99167528
57LMTK20.98571056
58MAP3K120.97432875
59RAF10.93503369
60STK110.93424740
61PRKCH0.90684828
62FES0.90294414
63CDK190.89910473
64PTK2B0.89902420
65CDK11A0.89482900
66MARK20.88603547
67PIM20.86989484
68DYRK1A0.80062738
69CAMK2A0.79337607
70MAP3K70.78327013
71PKN20.77368943
72FGFR40.76926877
73TESK10.71412449
74TRIB30.70438003
75PDK10.70328413
76LIMK10.69075587
77SCYL20.68803574
78CAMKK20.67038973
79CAMK2G0.65587248
80DAPK30.62910435
81AURKA0.62152565
82BCKDK0.61765608
83CAMK40.61666824
84MTOR0.58618929
85DDR20.58577812
86CSNK1G20.58575510
87PDPK10.57959944
88PRKCZ0.57317155
89ICK0.55863425
90BRSK10.55826197
91MAP3K10.55416010
92CAMK1G0.55222427
93CSNK1E0.52505905
94AKT20.51158140
95MAP2K10.50881322
96SGK2230.49628968
97SGK4940.49628968
98TNIK0.49266884
99PKN10.49084667
100IRAK20.48639134
101FER0.48280850
102EPHB20.47793203
103SGK10.47753912
104MAPK120.47625673
105MAP3K100.47488327
106FYN0.47022451
107RPS6KA20.46476005
108DYRK30.46383561
109RPS6KA30.45160912
110PRKG20.44745634
111WNK40.44417545
112VRK20.44263535
113DMPK0.43711831
114PNCK0.43481840
115CAMK2B0.42961027
116BMX0.42317728
117MAPK40.42303012
118PRKD20.41176526
119PAK10.40310766
120NEK60.39926543
121TAOK20.39887130
122MAPK100.39553951
123PTK20.39462394
124NME10.38962762
125PINK10.38807481
126SGK30.38369100
127MAPK80.37986253
128CASK0.37729655
129CDC42BPA0.36998976
130PRKCE0.36263215
131GSK3B0.36063817
132TESK20.35657411
133MAP2K60.35567082
134PDGFRA0.35259665
135MAP3K60.34148918
136MATK0.33423143
137DYRK20.29499681
138FGR0.29176770

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.81692123
2Synaptic vesicle cycle_Homo sapiens_hsa047213.31938571
3Nicotine addiction_Homo sapiens_hsa050333.15703249
4Circadian entrainment_Homo sapiens_hsa047132.65199223
5Olfactory transduction_Homo sapiens_hsa047402.56956477
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.56695590
7GABAergic synapse_Homo sapiens_hsa047272.41867975
8Long-term potentiation_Homo sapiens_hsa047202.40393746
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40213321
10Sulfur relay system_Homo sapiens_hsa041222.36359250
11Glutamatergic synapse_Homo sapiens_hsa047242.34244585
12Salivary secretion_Homo sapiens_hsa049702.26299377
13Morphine addiction_Homo sapiens_hsa050322.22936661
14Phenylalanine metabolism_Homo sapiens_hsa003602.14936370
15Amphetamine addiction_Homo sapiens_hsa050312.05859106
16Insulin secretion_Homo sapiens_hsa049112.04450009
17Cholinergic synapse_Homo sapiens_hsa047251.98164446
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94663099
19Dopaminergic synapse_Homo sapiens_hsa047281.92780933
20Gastric acid secretion_Homo sapiens_hsa049711.89250719
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89238107
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.82818014
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75814790
24Oxytocin signaling pathway_Homo sapiens_hsa049211.74235911
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.61288114
26Biosynthesis of amino acids_Homo sapiens_hsa012301.58715363
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55134871
28Renin secretion_Homo sapiens_hsa049241.49459712
29GnRH signaling pathway_Homo sapiens_hsa049121.47979979
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46958795
31Glioma_Homo sapiens_hsa052141.46649241
32Long-term depression_Homo sapiens_hsa047301.44935915
33Calcium signaling pathway_Homo sapiens_hsa040201.44054751
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.41916570
35Arginine and proline metabolism_Homo sapiens_hsa003301.38132522
36Gap junction_Homo sapiens_hsa045401.32557218
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31757568
38Complement and coagulation cascades_Homo sapiens_hsa046101.29479236
39Type II diabetes mellitus_Homo sapiens_hsa049301.28550843
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27952154
41Axon guidance_Homo sapiens_hsa043601.27834342
42Serotonergic synapse_Homo sapiens_hsa047261.27343970
43Estrogen signaling pathway_Homo sapiens_hsa049151.26483970
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26292453
45Galactose metabolism_Homo sapiens_hsa000521.25992053
46Taste transduction_Homo sapiens_hsa047421.25062941
47Cocaine addiction_Homo sapiens_hsa050301.18707673
48cAMP signaling pathway_Homo sapiens_hsa040241.17438266
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16028119
50ErbB signaling pathway_Homo sapiens_hsa040121.13652564
51Melanogenesis_Homo sapiens_hsa049161.09304037
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06918194
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03777151
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.01681151
55Collecting duct acid secretion_Homo sapiens_hsa049661.00606966
56Tyrosine metabolism_Homo sapiens_hsa003500.99373736
57Pyruvate metabolism_Homo sapiens_hsa006200.99196841
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97511449
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.92738152
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92612971
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.91578528
62Dilated cardiomyopathy_Homo sapiens_hsa054140.89067335
63mTOR signaling pathway_Homo sapiens_hsa041500.88711528
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88467934
65VEGF signaling pathway_Homo sapiens_hsa043700.88402815
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.87382753
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87139977
68Oocyte meiosis_Homo sapiens_hsa041140.85965971
69Cardiac muscle contraction_Homo sapiens_hsa042600.85902893
70Phototransduction_Homo sapiens_hsa047440.85478137
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82245862
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.81913508
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.81002828
74Ribosome_Homo sapiens_hsa030100.80933221
75Carbon metabolism_Homo sapiens_hsa012000.80466761
76Other glycan degradation_Homo sapiens_hsa005110.80179862
77Fructose and mannose metabolism_Homo sapiens_hsa000510.80069725
78Fatty acid biosynthesis_Homo sapiens_hsa000610.79610258
79Thyroid hormone synthesis_Homo sapiens_hsa049180.79451604
80Dorso-ventral axis formation_Homo sapiens_hsa043200.78226296
81Vibrio cholerae infection_Homo sapiens_hsa051100.75902456
82Basal cell carcinoma_Homo sapiens_hsa052170.75585950
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.75151222
84Pancreatic secretion_Homo sapiens_hsa049720.74977738
85Histidine metabolism_Homo sapiens_hsa003400.74857030
86Nitrogen metabolism_Homo sapiens_hsa009100.74477782
87Choline metabolism in cancer_Homo sapiens_hsa052310.73829275
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70428496
89Endometrial cancer_Homo sapiens_hsa052130.69750678
90Glucagon signaling pathway_Homo sapiens_hsa049220.69601321
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.68701390
92MAPK signaling pathway_Homo sapiens_hsa040100.67848330
93Bile secretion_Homo sapiens_hsa049760.67503830
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67102050
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64932935
96Endocytosis_Homo sapiens_hsa041440.64884594
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61201673
98Rap1 signaling pathway_Homo sapiens_hsa040150.61014343
99Non-small cell lung cancer_Homo sapiens_hsa052230.60728887
100Folate biosynthesis_Homo sapiens_hsa007900.60402349
101Ras signaling pathway_Homo sapiens_hsa040140.59291070
102Oxidative phosphorylation_Homo sapiens_hsa001900.58940466
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.58913336
104Notch signaling pathway_Homo sapiens_hsa043300.58556729
105Insulin signaling pathway_Homo sapiens_hsa049100.58292801
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57768177
107Renal cell carcinoma_Homo sapiens_hsa052110.57508746
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55147600
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54973481
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54553040
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54399768
112Pentose phosphate pathway_Homo sapiens_hsa000300.53764264
113Alzheimers disease_Homo sapiens_hsa050100.53104404
114beta-Alanine metabolism_Homo sapiens_hsa004100.52800547
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52721060
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51598848
117Steroid biosynthesis_Homo sapiens_hsa001000.51385653
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50778588
119Lysosome_Homo sapiens_hsa041420.49720368
120Prion diseases_Homo sapiens_hsa050200.48995384
121Hippo signaling pathway_Homo sapiens_hsa043900.47737388
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47513918
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46520634
124Wnt signaling pathway_Homo sapiens_hsa043100.45367481
125Colorectal cancer_Homo sapiens_hsa052100.43346072
126Hedgehog signaling pathway_Homo sapiens_hsa043400.42033062
127HIF-1 signaling pathway_Homo sapiens_hsa040660.41835902
128Lysine degradation_Homo sapiens_hsa003100.41820461
129Bladder cancer_Homo sapiens_hsa052190.41032339
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39552704
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39235357
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38698412
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38670257
134PPAR signaling pathway_Homo sapiens_hsa033200.37615961
135Chemokine signaling pathway_Homo sapiens_hsa040620.36905746
136Alcoholism_Homo sapiens_hsa050340.36336802
137Inositol phosphate metabolism_Homo sapiens_hsa005620.36037170
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34670323
139AMPK signaling pathway_Homo sapiens_hsa041520.33941003
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33378091
141Arginine biosynthesis_Homo sapiens_hsa002200.32533727
142Parkinsons disease_Homo sapiens_hsa050120.31976101
143Circadian rhythm_Homo sapiens_hsa047100.31826620
144Ovarian steroidogenesis_Homo sapiens_hsa049130.31200060

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