RTN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.87967516
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.62301682
3neuron cell-cell adhesion (GO:0007158)4.51509197
4locomotory exploration behavior (GO:0035641)4.44972850
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.33954249
6synaptic vesicle exocytosis (GO:0016079)4.24406913
7glutamate secretion (GO:0014047)4.20041707
8layer formation in cerebral cortex (GO:0021819)4.16762289
9vocalization behavior (GO:0071625)4.07907338
10regulation of synaptic vesicle exocytosis (GO:2000300)4.07093223
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.05304231
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.92626282
13protein localization to synapse (GO:0035418)3.84124925
14axon ensheathment in central nervous system (GO:0032291)3.83874471
15central nervous system myelination (GO:0022010)3.83874471
16dendritic spine morphogenesis (GO:0060997)3.79506707
17neuronal action potential propagation (GO:0019227)3.78357916
18exploration behavior (GO:0035640)3.69437436
19dendrite morphogenesis (GO:0048813)3.68340286
20ionotropic glutamate receptor signaling pathway (GO:0035235)3.62316944
21* neuron recognition (GO:0008038)3.60111133
22regulation of glutamate receptor signaling pathway (GO:1900449)3.53962662
23establishment of mitochondrion localization (GO:0051654)3.51910674
24regulation of long-term neuronal synaptic plasticity (GO:0048169)3.43975760
25regulation of synaptic vesicle transport (GO:1902803)3.42513125
26regulation of neuronal synaptic plasticity (GO:0048168)3.41374116
27presynaptic membrane assembly (GO:0097105)3.39513273
28negative regulation of neurotransmitter transport (GO:0051589)3.33681876
29glutamate receptor signaling pathway (GO:0007215)3.32608162
30regulation of synapse structural plasticity (GO:0051823)3.27959516
31presynaptic membrane organization (GO:0097090)3.25877264
32organelle transport along microtubule (GO:0072384)3.24581018
33vesicle transport along microtubule (GO:0047496)3.18632194
34transmission of nerve impulse (GO:0019226)3.18100821
35regulation of dendritic spine morphogenesis (GO:0061001)3.17838071
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.17287728
37* axonal fasciculation (GO:0007413)3.15290945
38neurotransmitter secretion (GO:0007269)3.14817777
39cell migration in hindbrain (GO:0021535)3.14082227
40cerebellar granule cell differentiation (GO:0021707)3.12708329
41postsynaptic membrane organization (GO:0001941)3.08965651
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.07043078
43neuron-neuron synaptic transmission (GO:0007270)3.06763673
44nerve growth factor signaling pathway (GO:0038180)3.04812814
45cellular potassium ion homeostasis (GO:0030007)3.03143703
46synaptic transmission, glutamatergic (GO:0035249)3.02842060
47negative regulation of neurotransmitter secretion (GO:0046929)3.02796222
48establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.01728556
49mitochondrion transport along microtubule (GO:0047497)3.01728556
50long-chain fatty acid biosynthetic process (GO:0042759)3.01475292
51gamma-aminobutyric acid transport (GO:0015812)3.01294025
52L-amino acid import (GO:0043092)3.00922348
53neuromuscular process controlling balance (GO:0050885)2.99451840
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.98845019
55cerebellar Purkinje cell layer development (GO:0021680)2.98397339
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94870903
57proline transport (GO:0015824)2.94309480
58regulation of excitatory postsynaptic membrane potential (GO:0060079)2.92906448
59regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.89116328
60regulation of dendritic spine development (GO:0060998)2.88013786
61mating behavior (GO:0007617)2.87268421
62cell communication by electrical coupling (GO:0010644)2.86132727
63regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84280117
64myelination (GO:0042552)2.83959709
65negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83238771
66regulation of synaptic plasticity (GO:0048167)2.83146063
67central nervous system projection neuron axonogenesis (GO:0021952)2.82624435
68long-term memory (GO:0007616)2.82486757
69ensheathment of neurons (GO:0007272)2.81572274
70axon ensheathment (GO:0008366)2.81572274
71potassium ion homeostasis (GO:0055075)2.81341468
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81311798
73positive regulation of synapse assembly (GO:0051965)2.81104610
74adult walking behavior (GO:0007628)2.80964155
75regulation of postsynaptic membrane potential (GO:0060078)2.80096005
76activation of protein kinase A activity (GO:0034199)2.80049982
77negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.79080815
78long-term synaptic potentiation (GO:0060291)2.78594479
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.77694244
80synapse organization (GO:0050808)2.76171855
81clathrin coat assembly (GO:0048268)2.75471575
82synapse assembly (GO:0007416)2.75074243
83positive regulation of dendritic spine morphogenesis (GO:0061003)2.73699640
84regulation of neurotransmitter secretion (GO:0046928)2.73516945
85regulation of vesicle fusion (GO:0031338)2.71356167
86neuronal ion channel clustering (GO:0045161)2.71235893
87neurotransmitter transport (GO:0006836)2.71058566
88synaptic vesicle endocytosis (GO:0048488)2.70107208
89positive regulation of membrane potential (GO:0045838)2.67970611
90positive regulation of synapse maturation (GO:0090129)2.66629135
91dendritic spine organization (GO:0097061)2.66505294
92neuron projection extension (GO:1990138)2.65411364
93neurotransmitter-gated ion channel clustering (GO:0072578)2.65224897
94neuron remodeling (GO:0016322)2.65151163
95regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65050517
96apical protein localization (GO:0045176)2.64936619
97auditory behavior (GO:0031223)2.62695876
98detection of calcium ion (GO:0005513)2.62132609
99axon extension (GO:0048675)2.61890621
100G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.60632564
101cytoskeletal anchoring at plasma membrane (GO:0007016)2.58959294
102axon cargo transport (GO:0008088)2.58702924
103regulation of synaptic transmission, glutamatergic (GO:0051966)2.57572474
104negative regulation of dendrite morphogenesis (GO:0050774)2.56942662
105membrane assembly (GO:0071709)2.56035778
106membrane depolarization during action potential (GO:0086010)2.56005854
107regulation of synapse assembly (GO:0051963)2.55210355
108sodium ion export (GO:0071436)2.54713383
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.54307143
110neuromuscular process (GO:0050905)2.53288856
111innervation (GO:0060384)2.53087356
112regulation of voltage-gated calcium channel activity (GO:1901385)2.52792194
113positive regulation of dendritic spine development (GO:0060999)2.52780483
114glycine transport (GO:0015816)2.52744182
115regulation of neurotransmitter transport (GO:0051588)2.52093795
116amino acid import (GO:0043090)2.46177080
117response to auditory stimulus (GO:0010996)2.44617395
118positive regulation of axon extension (GO:0045773)2.44235265
119regulation of axon extension involved in axon guidance (GO:0048841)2.43437051
120cellular sodium ion homeostasis (GO:0006883)2.42999147
121positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.41566401
122pyrimidine nucleobase catabolic process (GO:0006208)2.41156922
123neuromuscular synaptic transmission (GO:0007274)2.36658725
124potassium ion import (GO:0010107)2.36529575
125positive regulation of neurotransmitter transport (GO:0051590)2.34643435
126cell communication involved in cardiac conduction (GO:0086065)2.34568115
127membrane depolarization (GO:0051899)2.34197831
128regulation of synapse organization (GO:0050807)2.31505722
129regulation of axon guidance (GO:1902667)2.30212183
130urinary tract smooth muscle contraction (GO:0014848)2.29626466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.42648088
2GBX2_23144817_ChIP-Seq_PC3_Human3.32337748
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82606973
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74849896
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73346315
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50980909
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50980909
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36672617
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33239737
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29017206
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26403671
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.25992135
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25772766
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24444619
15DROSHA_22980978_ChIP-Seq_HELA_Human2.12850692
16AR_21572438_ChIP-Seq_LNCaP_Human2.11595482
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.05290108
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.01837104
19REST_21632747_ChIP-Seq_MESCs_Mouse2.00288962
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.99530169
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.99105715
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95324348
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93016009
24* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72038123
25TAF15_26573619_Chip-Seq_HEK293_Human1.68713678
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66949864
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65224795
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61219532
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.58772520
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58712226
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56831843
32* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56672097
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53160727
34SMAD4_21799915_ChIP-Seq_A2780_Human1.49930429
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48951903
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48762260
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45112714
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43757326
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43604806
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43373957
41* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41937889
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.41019492
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39943547
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.38826988
45TP53_16413492_ChIP-PET_HCT116_Human1.38172787
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37598239
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34790357
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34540777
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.33878609
50* PIAS1_25552417_ChIP-Seq_VCAP_Human1.33728797
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33697877
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32092688
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31033442
54* P300_19829295_ChIP-Seq_ESCs_Human1.30704313
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.30277760
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29161838
57STAT3_23295773_ChIP-Seq_U87_Human1.27707060
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25623595
59* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24748647
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24482221
61* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23668091
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.23512628
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22983603
64AHR_22903824_ChIP-Seq_MCF-7_Human1.22903354
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22522655
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.22220355
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.21760038
68* ZNF274_21170338_ChIP-Seq_K562_Hela1.21314590
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.17613415
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16621841
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16147469
72* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15574044
73AR_25329375_ChIP-Seq_VCAP_Human1.15366276
74ER_23166858_ChIP-Seq_MCF-7_Human1.13748656
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.13587222
76* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12879187
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.12291912
78FUS_26573619_Chip-Seq_HEK293_Human1.12195295
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.11068465
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10505244
81* TP53_18474530_ChIP-ChIP_U2OS_Human1.10295324
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10216592
83* CJUN_26792858_Chip-Seq_BT549_Human1.10200970
84AR_19668381_ChIP-Seq_PC3_Human1.10187715
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09687604
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09687604
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07964372
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07892504
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07046306
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06294987
91TP53_20018659_ChIP-ChIP_R1E_Mouse1.06052209
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05613060
93TCF4_23295773_ChIP-Seq_U87_Human1.05123545
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03271523
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02835026
96KDM2B_26808549_Chip-Seq_K562_Human1.02715072
97IGF1R_20145208_ChIP-Seq_DFB_Human1.02324376
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01518577
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01357540
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01296404
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00598378
102* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00522635
103* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99756866
104RUNX2_22187159_ChIP-Seq_PCA_Human0.97397727
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96806212
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96681911
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.96070154
108RXR_22108803_ChIP-Seq_LS180_Human0.95662963
109NANOG_18555785_Chip-Seq_ESCs_Mouse0.94903028
110RNF2_27304074_Chip-Seq_NSC_Mouse0.94111094
111* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94072087
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93876085
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.93741843
114* PRDM14_20953172_ChIP-Seq_ESCs_Human0.93258446
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92595002
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92275480
117JUN_21703547_ChIP-Seq_K562_Human0.92217929
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91863550
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91607021
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.91371967
121KDM2B_26808549_Chip-Seq_REH_Human0.91349722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.43439896
2MP0004270_analgesia4.38059183
3MP0003880_abnormal_central_pattern4.36079200
4MP0003635_abnormal_synaptic_transmissio3.52709897
5MP0002063_abnormal_learning/memory/cond2.81650026
6MP0009745_abnormal_behavioral_response2.74306725
7MP0002064_seizures2.72607772
8MP0002734_abnormal_mechanical_nocicepti2.63159960
9MP0008438_abnormal_cutaneous_collagen2.56142586
10MP0009046_muscle_twitch2.54733231
11MP0003329_amyloid_beta_deposits2.50132300
12MP0005423_abnormal_somatic_nervous2.47654812
13MP0000778_abnormal_nervous_system2.42244798
14MP0001486_abnormal_startle_reflex2.36591161
15MP0001968_abnormal_touch/_nociception2.33746465
16MP0002572_abnormal_emotion/affect_behav2.29616149
17MP0002272_abnormal_nervous_system2.25143803
18MP0009780_abnormal_chondrocyte_physiolo2.17850090
19MP0000920_abnormal_myelination2.14884156
20MP0001440_abnormal_grooming_behavior2.07667077
21MP0002733_abnormal_thermal_nociception1.97636773
22MP0002735_abnormal_chemical_nociception1.94415614
23MP0004885_abnormal_endolymph1.86471573
24MP0001970_abnormal_pain_threshold1.80310531
25MP0005623_abnormal_meninges_morphology1.75747558
26MP0003705_abnormal_hypodermis_morpholog1.74933278
27MP0004858_abnormal_nervous_system1.73595843
28MP0002184_abnormal_innervation1.73086690
29MP0002067_abnormal_sensory_capabilities1.70658558
30MP0000955_abnormal_spinal_cord1.70393121
31MP0002736_abnormal_nociception_after1.68370731
32MP0004145_abnormal_muscle_electrophysio1.62718967
33MP0001501_abnormal_sleep_pattern1.62522340
34MP0004811_abnormal_neuron_physiology1.62209179
35MP0004924_abnormal_behavior1.58765839
36MP0005386_behavior/neurological_phenoty1.58765839
37MP0001299_abnormal_eye_distance/1.53979763
38MP0004272_abnormal_basement_membrane1.53179105
39MP0003690_abnormal_glial_cell1.52130610
40MP0008569_lethality_at_weaning1.50980000
41MP0003634_abnormal_glial_cell1.50692064
42* MP0002882_abnormal_neuron_morphology1.50393016
43MP0001958_emphysema1.47394377
44MP0003279_aneurysm1.41306224
45MP0002066_abnormal_motor_capabilities/c1.41228287
46MP0002557_abnormal_social/conspecific_i1.39005036
47MP0004742_abnormal_vestibular_system1.38753815
48MP0000751_myopathy1.37860732
49MP0010386_abnormal_urinary_bladder1.36263608
50MP0006276_abnormal_autonomic_nervous1.35493469
51MP0002909_abnormal_adrenal_gland1.29710217
52MP0002822_catalepsy1.29196627
53MP0000604_amyloidosis1.25861873
54MP0001905_abnormal_dopamine_level1.25673130
55MP0000534_abnormal_ureter_morphology1.22644722
56MP0000747_muscle_weakness1.21419546
57MP0003632_abnormal_nervous_system1.20611776
58MP0000569_abnormal_digit_pigmentation1.20410069
59MP0001348_abnormal_lacrimal_gland1.19555850
60MP0005275_abnormal_skin_tensile1.17333063
61MP0002152_abnormal_brain_morphology1.16290640
62* MP0003633_abnormal_nervous_system1.15228614
63* MP0003631_nervous_system_phenotype1.13104386
64MP0002229_neurodegeneration1.11990567
65MP0001529_abnormal_vocalization1.10742251
66MP0004142_abnormal_muscle_tone1.05156278
67MP0000013_abnormal_adipose_tissue1.04085159
68MP0003123_paternal_imprinting1.01742176
69MP0005503_abnormal_tendon_morphology1.01402715
70MP0001177_atelectasis1.00460435
71MP0005257_abnormal_intraocular_pressure1.00280289
72MP0002295_abnormal_pulmonary_circulatio0.95850546
73MP0005171_absent_coat_pigmentation0.95453189
74MP0005409_darkened_coat_color0.94289657
75MP0005595_abnormal_vascular_smooth0.91359693
76MP0004510_myositis0.89933846
77MP0003879_abnormal_hair_cell0.88720275
78MP0002752_abnormal_somatic_nervous0.87815881
79MP0002896_abnormal_bone_mineralization0.86485659
80MP0001188_hyperpigmentation0.85797608
81MP0003950_abnormal_plasma_membrane0.85684498
82MP0002090_abnormal_vision0.85153532
83MP0010368_abnormal_lymphatic_system0.85130026
84MP0000566_synostosis0.83894075
85MP0003283_abnormal_digestive_organ0.83624345
86MP0001984_abnormal_olfaction0.83431458
87MP0001485_abnormal_pinna_reflex0.83039342
88MP0003566_abnormal_cell_adhesion0.82524815
89MP0005551_abnormal_eye_electrophysiolog0.81953928
90MP0004233_abnormal_muscle_weight0.78564119
91MP0001502_abnormal_circadian_rhythm0.77532831
92MP0005645_abnormal_hypothalamus_physiol0.77167103
93MP0001963_abnormal_hearing_physiology0.74911252
94MP0001542_abnormal_bone_strength0.74495133
95* MP0003861_abnormal_nervous_system0.72915140
96MP0003385_abnormal_body_wall0.72312442
97MP0003942_abnormal_urinary_system0.72256398
98MP0000579_abnormal_nail_morphology0.70924183
99MP0003122_maternal_imprinting0.70753189
100MP0003787_abnormal_imprinting0.70605002
101MP0004085_abnormal_heartbeat0.70064632
102MP0004130_abnormal_muscle_cell0.69836172
103MP0009250_abnormal_appendicular_skeleto0.68932782
104MP0003172_abnormal_lysosome_physiology0.68641071
105MP0002069_abnormal_eating/drinking_beha0.68514927
106MP0000537_abnormal_urethra_morphology0.67621483
107MP0005646_abnormal_pituitary_gland0.66617212
108MP0002837_dystrophic_cardiac_calcinosis0.66295365
109MP0008874_decreased_physiological_sensi0.65999318
110MP0000759_abnormal_skeletal_muscle0.65500183
111MP0001943_abnormal_respiration0.65310549
112MP0005620_abnormal_muscle_contractility0.64571183
113MP0003137_abnormal_impulse_conducting0.64185700
114MP0004215_abnormal_myocardial_fiber0.64161286
115MP0004134_abnormal_chest_morphology0.62911764
116MP0009384_cardiac_valve_regurgitation0.62661101
117MP0004484_altered_response_of0.62424641
118MP0000631_abnormal_neuroendocrine_gland0.62330240
119MP0003091_abnormal_cell_migration0.61369945
120MP0010678_abnormal_skin_adnexa0.60738944
121MP0000749_muscle_degeneration0.60581321
122MP0005187_abnormal_penis_morphology0.60523992
123MP0000462_abnormal_digestive_system0.60475650
124MP0002234_abnormal_pharynx_morphology0.60475372
125MP0000003_abnormal_adipose_tissue0.59231065

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.72570165
2Neurofibrillary tangles (HP:0002185)4.65972242
3Myokymia (HP:0002411)4.41627199
4Cerebral inclusion bodies (HP:0100314)4.31193026
5Supranuclear gaze palsy (HP:0000605)4.22333309
6Focal seizures (HP:0007359)4.08721476
7Abnormality of the corticospinal tract (HP:0002492)4.05285176
8Termporal pattern (HP:0011008)4.00183045
9Insidious onset (HP:0003587)4.00183045
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.79052202
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.79052202
12Protrusio acetabuli (HP:0003179)3.58580042
13Visual hallucinations (HP:0002367)3.55815387
14Premature rupture of membranes (HP:0001788)3.42714194
15Atonic seizures (HP:0010819)3.42049475
16Ankle clonus (HP:0011448)3.37418676
17Epileptic encephalopathy (HP:0200134)3.35788016
18Action tremor (HP:0002345)3.22583971
19Mutism (HP:0002300)3.21036084
20Akinesia (HP:0002304)3.07499804
21Type 1 muscle fiber predominance (HP:0003803)3.06632853
22Vascular tortuosity (HP:0004948)3.01602061
23Arterial tortuosity (HP:0005116)2.92382756
24Broad-based gait (HP:0002136)2.91723995
25Spastic gait (HP:0002064)2.91409823
26Absence seizures (HP:0002121)2.91155967
27Dysmetria (HP:0001310)2.85702725
28Progressive cerebellar ataxia (HP:0002073)2.84277502
29Urinary urgency (HP:0000012)2.83302219
30Urinary bladder sphincter dysfunction (HP:0002839)2.82458589
31Dialeptic seizures (HP:0011146)2.76330719
32Drooling (HP:0002307)2.71615083
33Excessive salivation (HP:0003781)2.71615083
34Generalized tonic-clonic seizures (HP:0002069)2.71341952
35Papilledema (HP:0001085)2.63073062
36Intention tremor (HP:0002080)2.61134245
37Lower limb muscle weakness (HP:0007340)2.55154190
38Atrophic scars (HP:0001075)2.53207052
39Fetal akinesia sequence (HP:0001989)2.50264904
40Lower limb amyotrophy (HP:0007210)2.46593577
41Impaired vibration sensation in the lower limbs (HP:0002166)2.45409133
42Megalencephaly (HP:0001355)2.44696860
43Dysdiadochokinesis (HP:0002075)2.42992851
44Broad metatarsal (HP:0001783)2.42989702
45Shallow orbits (HP:0000586)2.42815244
46Poor eye contact (HP:0000817)2.42366766
47Scanning speech (HP:0002168)2.40330355
48Hypoventilation (HP:0002791)2.37834542
49Hyperventilation (HP:0002883)2.36964779
50Peripheral hypomyelination (HP:0007182)2.35368307
51Limb dystonia (HP:0002451)2.31855619
52Truncal ataxia (HP:0002078)2.31241492
53Pheochromocytoma (HP:0002666)2.30788780
54Onion bulb formation (HP:0003383)2.26349882
55Spinal rigidity (HP:0003306)2.25281327
56Abnormality of binocular vision (HP:0011514)2.25072913
57Diplopia (HP:0000651)2.25072913
58Abnormality of dentin (HP:0010299)2.24363443
59Depression (HP:0000716)2.22589705
60Abnormal social behavior (HP:0012433)2.22356966
61Impaired social interactions (HP:0000735)2.22356966
62Absent speech (HP:0001344)2.21842727
63Focal dystonia (HP:0004373)2.21767584
64Inappropriate behavior (HP:0000719)2.21129057
65Febrile seizures (HP:0002373)2.20830623
66Progressive inability to walk (HP:0002505)2.18684406
67Ankle contracture (HP:0006466)2.17177873
68Aortic dissection (HP:0002647)2.16503392
69Amyotrophic lateral sclerosis (HP:0007354)2.16332249
70Difficulty running (HP:0009046)2.15013547
71Overgrowth (HP:0001548)2.14739802
72Neuronal loss in central nervous system (HP:0002529)2.14668970
73Aplasia involving bones of the extremities (HP:0009825)2.13893316
74Aplasia involving bones of the upper limbs (HP:0009823)2.13893316
75Aplasia of the phalanges of the hand (HP:0009802)2.13893316
76Genetic anticipation (HP:0003743)2.13715148
77Bladder diverticulum (HP:0000015)2.13575877
78Aortic aneurysm (HP:0004942)2.13558380
79Slender build (HP:0001533)2.11067654
80Amblyopia (HP:0000646)2.09295806
81Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.09040417
82Gaze-evoked nystagmus (HP:0000640)2.06999422
83Buphthalmos (HP:0000557)2.06648601
84Abnormal eating behavior (HP:0100738)2.06444088
85Wormian bones (HP:0002645)2.05922774
86Mildly elevated creatine phosphokinase (HP:0008180)2.04811942
87Apathy (HP:0000741)2.03514406
88Postural instability (HP:0002172)2.03403264
89Upper limb amyotrophy (HP:0009129)2.03122930
90Distal upper limb amyotrophy (HP:0007149)2.03122930
91Aqueductal stenosis (HP:0002410)2.02216007
92Morphological abnormality of the pyramidal tract (HP:0002062)2.01902130
93Fragile skin (HP:0001030)2.01543324
94Craniofacial dystonia (HP:0012179)2.01476520
95Muscle fiber inclusion bodies (HP:0100299)2.01351929
96Follicular hyperkeratosis (HP:0007502)2.00307025
97Neonatal short-limb short stature (HP:0008921)1.99748221
98Hammertoe (HP:0001765)1.98459825
99Anxiety (HP:0000739)1.96724977
100Rapidly progressive (HP:0003678)1.96501270
101Hemiparesis (HP:0001269)1.93735035
102Nemaline bodies (HP:0003798)1.92473739
103Distal lower limb amyotrophy (HP:0008944)1.91830925
104Generalized myoclonic seizures (HP:0002123)1.90415608
105Abnormality of salivation (HP:0100755)1.89133277
106Clumsiness (HP:0002312)1.88803706
107Bronchomalacia (HP:0002780)1.88253392
108Neuroendocrine neoplasm (HP:0100634)1.87888535
109Insomnia (HP:0100785)1.87347244
110Sensory axonal neuropathy (HP:0003390)1.87228068
111Epileptiform EEG discharges (HP:0011182)1.87016094
112Hyporeflexia of lower limbs (HP:0002600)1.86720760
113Achilles tendon contracture (HP:0001771)1.86524615
114Bowel diverticulosis (HP:0005222)1.86327252
115Retinal dysplasia (HP:0007973)1.83759657
116Obstructive sleep apnea (HP:0002870)1.83319215
117Bradycardia (HP:0001662)1.82912659
118Polyphagia (HP:0002591)1.82500507
119EEG with generalized epileptiform discharges (HP:0011198)1.82136531
120Torticollis (HP:0000473)1.81950246
121Stereotypic behavior (HP:0000733)1.81441942
122Clonus (HP:0002169)1.80388721
123Soft skin (HP:0000977)1.79888262
124Round ear (HP:0100830)1.79775956
125Hyperextensible skin (HP:0000974)1.79233702
126Coronal craniosynostosis (HP:0004440)1.76321414
127Thickened helices (HP:0000391)1.76175072
128Bowel incontinence (HP:0002607)1.75953032
129Diminished motivation (HP:0000745)1.75274231
130Agitation (HP:0000713)1.74731311
131Hypsarrhythmia (HP:0002521)1.74417783
132Limb-girdle muscle weakness (HP:0003325)1.72665073
133Abnormality of the lower motor neuron (HP:0002366)1.72171719
134Turricephaly (HP:0000262)1.70773658
135Abnormal large intestine physiology (HP:0012700)1.67542840
136Difficulty climbing stairs (HP:0003551)1.67390056
137Widely spaced teeth (HP:0000687)1.67319952
138Delayed gross motor development (HP:0002194)1.66749227
139Sleep apnea (HP:0010535)1.66576308
140Increased variability in muscle fiber diameter (HP:0003557)1.65916468
141Hand muscle atrophy (HP:0009130)1.65557109
142Foot dorsiflexor weakness (HP:0009027)1.65110066
143Relative macrocephaly (HP:0004482)1.64620978
144Cerebral aneurysm (HP:0004944)1.64105796
145Hypoplasia of the brainstem (HP:0002365)1.62971640
146Aplasia/Hypoplasia of the brainstem (HP:0007362)1.62971640
147Bundle branch block (HP:0011710)1.62110603
148Limited hip movement (HP:0008800)1.61210254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.43482783
2MAP3K93.42488099
3EPHA43.15460145
4NTRK33.08260187
5PAK62.48253286
6MAP3K42.43128286
7NTRK12.42276171
8STK392.42259678
9MINK12.30172493
10PNCK2.29456686
11KSR21.98680851
12OXSR11.81143668
13PHKG11.80505393
14PHKG21.80505393
15CASK1.74749267
16LATS21.66348123
17EPHB21.64067396
18MAP2K71.62275630
19DAPK21.59914205
20PLK21.49852547
21NTRK21.49538858
22CDK51.48800566
23RIPK11.48285367
24MAP2K41.43710307
25KSR11.37779215
26TYRO31.36157433
27PKN11.33953343
28MAP3K21.33582557
29PAK31.30527542
30PRKD31.30351759
31RIPK41.30310112
32CSNK1G21.25417558
33UHMK11.25264495
34MAPK131.23610159
35TESK11.22972106
36CAMKK11.21434504
37CDK191.20123658
38CDK141.15454168
39LIMK11.15445617
40FGFR21.15371327
41TNIK1.10213492
42RET1.07526917
43MYLK1.06413131
44FGR1.04448583
45CDK151.04376786
46CAMK2A1.03438874
47WNK11.02826896
48CAMK2B1.02521386
49CDK181.01317487
50TTN1.01146982
51PINK11.00328870
52GRK50.98431207
53MARK20.96209074
54SGK20.93595715
55MAPKAPK50.93159611
56BCR0.92059541
57DDR20.91953317
58PRPF4B0.90326288
59SGK30.90286072
60STK110.89870014
61CDK11A0.89473682
62FES0.88842406
63DMPK0.88317354
64DYRK20.88226615
65ROCK10.88213769
66CAMK1G0.86512918
67ROCK20.84755551
68PAK20.84730131
69EPHB10.83228537
70SIK20.82637207
71CSNK1G30.82465643
72PRKCG0.81584273
73ALK0.79388345
74CSNK1A1L0.78849244
75WNK40.78202421
76SGK2230.77696845
77SGK4940.77696845
78CAMK10.77632712
79AKT30.76784766
80CAMKK20.76000226
81CAMK2D0.74831915
82FER0.72726038
83ICK0.68814831
84PTK2B0.68695153
85PRKCE0.68398363
86LMTK20.65562428
87ARAF0.64927615
88MET0.63806167
89PDPK10.62649107
90SCYL20.61212312
91PRKCH0.61197405
92DYRK1A0.61107402
93SGK10.59745094
94PRKG20.59028928
95MOS0.54421257
96OBSCN0.53893535
97CSNK1G10.53795086
98* FYN0.53778020
99STK380.52884632
100ERBB30.51751451
101LATS10.51687964
102PRKG10.50811822
103CAMK2G0.50110167
104ERBB40.49899143
105RPS6KA20.49869965
106PRKCZ0.48546402
107SIK10.48101127
108PTK20.48054631
109PDK10.47089638
110MAP3K120.46954297
111MAPK120.46867809
112TAOK10.45882636
113NEK60.45498226
114ABL20.43922844
115PDGFRA0.43503192
116MAP3K130.43442783
117PDGFRB0.42818819
118MAP2K10.42679700
119BRAF0.42488025
120MAP3K60.41493512
121GSK3A0.41249476
122RPS6KA30.41089509
123RAF10.39384939
124WNK30.38474500
125MAPK40.35656475
126* MAPK100.35321502

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.58253451
2Synaptic vesicle cycle_Homo sapiens_hsa047212.50402485
3GABAergic synapse_Homo sapiens_hsa047272.23591748
4Long-term potentiation_Homo sapiens_hsa047202.23232873
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20712717
6Glutamatergic synapse_Homo sapiens_hsa047242.20380017
7Circadian entrainment_Homo sapiens_hsa047132.14941508
8Dopaminergic synapse_Homo sapiens_hsa047281.98972449
9Morphine addiction_Homo sapiens_hsa050321.97716223
10Olfactory transduction_Homo sapiens_hsa047401.97681421
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93205908
12Amphetamine addiction_Homo sapiens_hsa050311.92090772
13Salivary secretion_Homo sapiens_hsa049701.83801587
14Long-term depression_Homo sapiens_hsa047301.83018771
15Axon guidance_Homo sapiens_hsa043601.82945638
16Cholinergic synapse_Homo sapiens_hsa047251.73497150
17Serotonergic synapse_Homo sapiens_hsa047261.70774923
18Renin secretion_Homo sapiens_hsa049241.64805935
19Gastric acid secretion_Homo sapiens_hsa049711.63815652
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56706530
21Oxytocin signaling pathway_Homo sapiens_hsa049211.55574556
22Cocaine addiction_Homo sapiens_hsa050301.50483115
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49526026
24Insulin secretion_Homo sapiens_hsa049111.48682132
25Gap junction_Homo sapiens_hsa045401.46858485
26GnRH signaling pathway_Homo sapiens_hsa049121.40038066
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36649301
28Taste transduction_Homo sapiens_hsa047421.31748511
29ECM-receptor interaction_Homo sapiens_hsa045121.31021966
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30303823
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26519985
32Glioma_Homo sapiens_hsa052141.25319226
33ErbB signaling pathway_Homo sapiens_hsa040121.22748666
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22528474
35Estrogen signaling pathway_Homo sapiens_hsa049151.21237481
36Collecting duct acid secretion_Homo sapiens_hsa049661.19054005
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16465168
38Renal cell carcinoma_Homo sapiens_hsa052111.16351580
39Calcium signaling pathway_Homo sapiens_hsa040201.16015561
40Dorso-ventral axis formation_Homo sapiens_hsa043201.15165251
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14491550
42Melanogenesis_Homo sapiens_hsa049161.08068624
43cAMP signaling pathway_Homo sapiens_hsa040241.06883400
44Type II diabetes mellitus_Homo sapiens_hsa049301.04521979
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.00079540
46Dilated cardiomyopathy_Homo sapiens_hsa054140.99644520
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.99568487
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98374035
49Sphingolipid signaling pathway_Homo sapiens_hsa040710.96564268
50Vibrio cholerae infection_Homo sapiens_hsa051100.96309566
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95703131
52Phototransduction_Homo sapiens_hsa047440.93751540
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87927944
54Circadian rhythm_Homo sapiens_hsa047100.87362929
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86930193
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86317975
57Choline metabolism in cancer_Homo sapiens_hsa052310.86186038
58VEGF signaling pathway_Homo sapiens_hsa043700.84417315
59Bile secretion_Homo sapiens_hsa049760.83953938
60Ras signaling pathway_Homo sapiens_hsa040140.83738234
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83379661
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82829471
63MAPK signaling pathway_Homo sapiens_hsa040100.82195638
64Steroid biosynthesis_Homo sapiens_hsa001000.80655251
65Protein digestion and absorption_Homo sapiens_hsa049740.79713874
66Endocytosis_Homo sapiens_hsa041440.79178057
67Tight junction_Homo sapiens_hsa045300.78978008
68Oocyte meiosis_Homo sapiens_hsa041140.76577861
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76251967
70Pancreatic secretion_Homo sapiens_hsa049720.74750540
71Vitamin B6 metabolism_Homo sapiens_hsa007500.73917020
72Cardiac muscle contraction_Homo sapiens_hsa042600.72150469
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72110479
74Ether lipid metabolism_Homo sapiens_hsa005650.71398370
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.69895824
76Rap1 signaling pathway_Homo sapiens_hsa040150.69488374
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69161277
78Glucagon signaling pathway_Homo sapiens_hsa049220.66980874
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66725013
80Thyroid hormone synthesis_Homo sapiens_hsa049180.63424943
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62047828
82Adherens junction_Homo sapiens_hsa045200.60740144
83Wnt signaling pathway_Homo sapiens_hsa043100.60517646
84Focal adhesion_Homo sapiens_hsa045100.59525889
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59498161
86Endometrial cancer_Homo sapiens_hsa052130.57870759
87mTOR signaling pathway_Homo sapiens_hsa041500.57709784
88AMPK signaling pathway_Homo sapiens_hsa041520.57314102
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55975715
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54767054
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53983707
92Prion diseases_Homo sapiens_hsa050200.53834498
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53831402
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53426703
95Hippo signaling pathway_Homo sapiens_hsa043900.51730941
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51521997
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50773941
98Nitrogen metabolism_Homo sapiens_hsa009100.49946537
99Proteoglycans in cancer_Homo sapiens_hsa052050.48920463
100Mineral absorption_Homo sapiens_hsa049780.47263626
101Phagosome_Homo sapiens_hsa041450.47091031
102Ovarian steroidogenesis_Homo sapiens_hsa049130.47066193
103Hedgehog signaling pathway_Homo sapiens_hsa043400.46809521
104Fatty acid biosynthesis_Homo sapiens_hsa000610.46633772
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46204396
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45379671
107Colorectal cancer_Homo sapiens_hsa052100.44880349
108Platelet activation_Homo sapiens_hsa046110.44714919
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44628037
110Alcoholism_Homo sapiens_hsa050340.44611011
111Insulin signaling pathway_Homo sapiens_hsa049100.44402820
112Non-small cell lung cancer_Homo sapiens_hsa052230.43639325
113Melanoma_Homo sapiens_hsa052180.42577841
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42120994
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41639845
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41273414
117Amoebiasis_Homo sapiens_hsa051460.41132785
118Inositol phosphate metabolism_Homo sapiens_hsa005620.40466835
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39743314

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