RTFDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.46587030
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98436739
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.98436739
4antigen processing and presentation of endogenous antigen (GO:0019883)3.89037154
5melanin biosynthetic process (GO:0042438)3.83192440
6protein maturation by protein folding (GO:0022417)3.81103540
7COPI coating of Golgi vesicle (GO:0048205)3.69388614
8Golgi transport vesicle coating (GO:0048200)3.69388614
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.65843529
10regulation of superoxide anion generation (GO:0032928)3.60967166
11respiratory burst (GO:0045730)3.53279463
12neutrophil activation involved in immune response (GO:0002283)3.47819404
13cullin deneddylation (GO:0010388)3.41337814
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.39119604
15melanin metabolic process (GO:0006582)3.39066148
16immunoglobulin mediated immune response (GO:0016064)3.34152419
17protein deneddylation (GO:0000338)3.33936765
18pentose-phosphate shunt (GO:0006098)3.31872016
19NIK/NF-kappaB signaling (GO:0038061)3.30968053
20deoxyribose phosphate biosynthetic process (GO:0046385)3.25809213
212-deoxyribonucleotide biosynthetic process (GO:0009265)3.25809213
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24369189
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.20884394
24purine nucleotide salvage (GO:0032261)3.19945597
25secondary metabolite biosynthetic process (GO:0044550)3.16409265
26regulation of triglyceride catabolic process (GO:0010896)3.16264159
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.15442834
28aldehyde catabolic process (GO:0046185)3.15322136
29antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.13779719
30ATP synthesis coupled proton transport (GO:0015986)3.13170175
31energy coupled proton transport, down electrochemical gradient (GO:0015985)3.13170175
32positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10268320
33negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.07754184
34regulation of cellular amine metabolic process (GO:0033238)3.07186060
35cellular extravasation (GO:0045123)3.06900961
36positive regulation of B cell differentiation (GO:0045579)3.04739746
37ribosomal small subunit assembly (GO:0000028)3.02862180
38positive regulation of ligase activity (GO:0051351)2.97756895
39pinocytosis (GO:0006907)2.96822120
40regulation of B cell receptor signaling pathway (GO:0050855)2.95499830
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.93564859
42respiratory electron transport chain (GO:0022904)2.93160504
43phagosome maturation (GO:0090382)2.91621091
44regulation of RIG-I signaling pathway (GO:0039535)2.90645066
45GDP-mannose metabolic process (GO:0019673)2.89119734
46NADPH regeneration (GO:0006740)2.87694152
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.87343528
48electron transport chain (GO:0022900)2.86423681
49deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.86245692
50positive regulation of cell cycle arrest (GO:0071158)2.85131075
51regulation of superoxide metabolic process (GO:0090322)2.82528942
52deoxyribonucleotide biosynthetic process (GO:0009263)2.78148491
53positive regulation of gamma-delta T cell activation (GO:0046645)2.77028474
54pentose metabolic process (GO:0019321)2.75175831
55amyloid precursor protein catabolic process (GO:0042987)2.72934541
56B cell mediated immunity (GO:0019724)2.72834750
57positive regulation of antigen processing and presentation (GO:0002579)2.72008852
58energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.71034899
59ATP hydrolysis coupled proton transport (GO:0015991)2.71034899
60glucose catabolic process (GO:0006007)2.70575388
61chaperone mediated protein folding requiring cofactor (GO:0051085)2.70368141
62regulation of B cell differentiation (GO:0045577)2.70132943
63DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.69385148
64nucleoside salvage (GO:0043174)2.68641793
65L-methionine salvage (GO:0071267)2.66889488
66L-methionine biosynthetic process (GO:0071265)2.66889488
67amino acid salvage (GO:0043102)2.66889488
68viral mRNA export from host cell nucleus (GO:0046784)2.63567294
69regulation of ubiquitin-protein transferase activity (GO:0051438)2.63550257
70pyrimidine nucleoside salvage (GO:0043097)2.62442359
71pyrimidine-containing compound salvage (GO:0008655)2.62442359
72proteasome assembly (GO:0043248)2.61771440
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.61358556
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60764170
75L-phenylalanine catabolic process (GO:0006559)2.60764170
76galactose catabolic process (GO:0019388)2.58012538
77guanosine-containing compound biosynthetic process (GO:1901070)2.56740666
78purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.56507125
79nucleobase-containing small molecule interconversion (GO:0015949)2.56381145
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.56207737
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.55846162
82L-phenylalanine metabolic process (GO:0006558)2.55846162
83primary alcohol catabolic process (GO:0034310)2.55357324
84regulation of ligase activity (GO:0051340)2.55092786
85antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.54955729
86sequestering of actin monomers (GO:0042989)2.54894922
87regulation of cellular amino acid metabolic process (GO:0006521)2.53644522
88NADH metabolic process (GO:0006734)2.53641216
89GMP metabolic process (GO:0046037)2.53511107
90regulation of response to interferon-gamma (GO:0060330)2.53184959
91purine-containing compound salvage (GO:0043101)2.53064093
92cofactor catabolic process (GO:0051187)2.52963928
93disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.50938607
94killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.50938607
95DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50862403
96regulation of cholesterol esterification (GO:0010872)2.50358808
97regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.49376908
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.49170778
99positive regulation of interferon-alpha production (GO:0032727)2.48646380
100protein complex biogenesis (GO:0070271)2.48057587
101myeloid cell activation involved in immune response (GO:0002275)2.46888180
102alpha-linolenic acid metabolic process (GO:0036109)2.46283091
103protein targeting to mitochondrion (GO:0006626)2.44992980
104negative regulation of B cell apoptotic process (GO:0002903)2.44501163
105G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.44264821
106signal transduction in response to DNA damage (GO:0042770)2.42686034
107negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.42597098
108negative regulation of cell cycle G1/S phase transition (GO:1902807)2.42597098
109leukocyte mediated cytotoxicity (GO:0001909)2.42474836
110S-adenosylmethionine metabolic process (GO:0046500)2.42466257
111antigen processing and presentation of exogenous peptide antigen (GO:0002478)2.42315499
112mast cell activation (GO:0045576)2.42230768
113intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.42041712
114signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42041712
115fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.42006904
116regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.41485340
117triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.40321541
118establishment of viral latency (GO:0019043)2.39854315
119positive regulation by symbiont of host defense response (GO:0052509)2.39396827
120modulation by symbiont of host defense response (GO:0052031)2.39396827
121modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39396827
122modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39396827
123positive regulation by organism of defense response of other organism involved in symbiotic interact2.39396827
124modulation by symbiont of host immune response (GO:0052553)2.39396827
125negative regulation of protein ubiquitination (GO:0031397)2.38883093
126neutrophil activation (GO:0042119)2.37602048
127regulation of cell cycle arrest (GO:0071156)2.37520172
128signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.37209085
129signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.37209085
130signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.37209085
131negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.36837797
132antigen processing and presentation of exogenous antigen (GO:0019884)2.36815308
133GTP biosynthetic process (GO:0006183)2.35935988
134establishment of protein localization to mitochondrial membrane (GO:0090151)2.35832817
135xenobiotic catabolic process (GO:0042178)2.34289676
136regulation of interferon-alpha production (GO:0032647)2.34152729
137regulation of antigen processing and presentation (GO:0002577)2.33284013
138regulation of cholesterol storage (GO:0010885)2.33198520
139positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.32603466
140actin nucleation (GO:0045010)2.31942948
141leukocyte degranulation (GO:0043299)2.31254333
142negative regulation of ligase activity (GO:0051352)2.31123440
143negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.31123440
144aromatic amino acid family catabolic process (GO:0009074)2.30579125
145DNA deamination (GO:0045006)2.29713467
146positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.28675901
147leukocyte aggregation (GO:0070486)2.27290684
148regulation of interferon-beta biosynthetic process (GO:0045357)2.26586565
149response to thyroid hormone (GO:0097066)2.26496478
150T cell migration (GO:0072678)2.26436417
151macrophage activation involved in immune response (GO:0002281)2.25779539
152production of molecular mediator involved in inflammatory response (GO:0002532)2.25597158
153natural killer cell mediated cytotoxicity (GO:0042267)2.25233248
154natural killer cell mediated immunity (GO:0002228)2.25233248
155negative regulation of phagocytosis (GO:0050765)2.25078914
156signal transduction involved in DNA damage checkpoint (GO:0072422)2.24881656
157signal transduction involved in DNA integrity checkpoint (GO:0072401)2.24881656
158signal transduction involved in cell cycle checkpoint (GO:0072395)2.23677176
159regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.22632197
160oxaloacetate metabolic process (GO:0006107)2.22531044
161rRNA modification (GO:0000154)2.22298401
162germinal center formation (GO:0002467)2.22125498
163regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.21166936
164heme metabolic process (GO:0042168)2.20153570
165hepatocyte apoptotic process (GO:0097284)2.19712451
166response to interferon-beta (GO:0035456)2.17788637
167antigen processing and presentation via MHC class Ib (GO:0002475)2.17274852
168sulfur amino acid catabolic process (GO:0000098)2.16831709

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.83914949
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.33676035
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.20883146
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.00377900
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99891955
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88082110
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.82630613
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.80400688
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.69270073
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.59108631
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.54962568
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.51945251
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51265892
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.49791869
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46608536
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43828576
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.29262015
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22497369
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.21351348
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.19584967
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16770658
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.14090736
23PPARA_22158963_ChIP-Seq_LIVER_Mouse2.13424768
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07227100
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.05800849
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05471224
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05310167
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91350479
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88435113
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88349749
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.87188361
32SPI1_23547873_ChIP-Seq_NB4_Human1.85345146
33TFEB_21752829_ChIP-Seq_HELA_Human1.83157221
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.74797645
35VDR_23849224_ChIP-Seq_CD4+_Human1.74101282
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71462245
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68366741
38GATA1_22025678_ChIP-Seq_K562_Human1.67681661
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65818796
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63613177
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.61528824
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55844958
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53211077
44FOXP3_21729870_ChIP-Seq_TREG_Human1.52040022
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51475258
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49772532
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48484633
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48068636
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46528131
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.46295160
51BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44199897
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42561015
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37619718
54ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37614118
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37411457
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36157250
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33419399
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33018083
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31992654
60VDR_21846776_ChIP-Seq_THP-1_Human1.31370043
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30720792
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.30330833
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29544903
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29288017
65GABP_19822575_ChIP-Seq_HepG2_Human1.28958813
66DCP1A_22483619_ChIP-Seq_HELA_Human1.28745390
67E2F7_22180533_ChIP-Seq_HELA_Human1.28131354
68XRN2_22483619_ChIP-Seq_HELA_Human1.27495897
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25846571
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25837084
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25805913
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25620574
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25537601
74MYB_26560356_Chip-Seq_TH2_Human1.25190420
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.25072961
76ELK1_19687146_ChIP-ChIP_HELA_Human1.23131329
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22629545
78MYC_22102868_ChIP-Seq_BL_Human1.21764128
79MAF_26560356_Chip-Seq_TH1_Human1.21544314
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21516764
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20611145
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19384950
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19207890
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19089204
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18757228
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18630876
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17951710
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17894806
89SCL_19346495_ChIP-Seq_HPC-7_Human1.15627064
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.15423143
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14293168
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14046727
93KDM5A_27292631_Chip-Seq_BREAST_Human1.13452091
94MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13288647
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12914288
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12153768
97GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11348565
98SPI1_23127762_ChIP-Seq_K562_Human1.11290881
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10429414
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10252851
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10049394
102MAF_26560356_Chip-Seq_TH2_Human1.09844765
103MYB_26560356_Chip-Seq_TH1_Human1.09231328
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08702355
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08554148
106HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08551733
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07942390
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07610004
109CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07303142
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06233184
111ELK1_22589737_ChIP-Seq_MCF10A_Human1.05819325
112VDR_24763502_ChIP-Seq_THP-1_Human1.05334422
113CIITA_25753668_ChIP-Seq_RAJI_Human1.04801902
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04551860
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03353527
116CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03165749
117UTX_26944678_Chip-Seq_JUKART_Human1.02945146
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.02298874
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02287856
120CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02129375
121BCL6_27268052_Chip-Seq_Bcells_Human1.01197958
122MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99759932
123TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99127431
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98853957
125THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98796589
126NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98698885
127TTF2_22483619_ChIP-Seq_HELA_Human0.98625399
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.98015159
129POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97164018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.16624929
2MP0001835_abnormal_antigen_presentation3.87886795
3MP0003191_abnormal_cellular_cholesterol3.49003838
4MP0003436_decreased_susceptibility_to3.28645510
5MP0002877_abnormal_melanocyte_morpholog3.20589217
6MP0005408_hypopigmentation3.14518582
7MP0009840_abnormal_foam_cell3.05960757
8MP0009785_altered_susceptibility_to2.99156113
9MP0005671_abnormal_response_to2.90689866
10MP0000015_abnormal_ear_pigmentation2.86598813
11MP0006082_CNS_inflammation2.83340659
12MP0003806_abnormal_nucleotide_metabolis2.53990709
13MP0000685_abnormal_immune_system2.44276833
14MP0005025_abnormal_response_to2.43866006
15MP0005000_abnormal_immune_tolerance2.43106370
16MP0002419_abnormal_innate_immunity2.42674408
17MP0002139_abnormal_hepatobiliary_system2.39756207
18MP0005171_absent_coat_pigmentation2.38494067
19MP0005464_abnormal_platelet_physiology2.35787402
20MP0005058_abnormal_lysosome_morphology2.33173616
21MP0002148_abnormal_hypersensitivity_rea2.27833280
22MP0001800_abnormal_humoral_immune2.25952043
23MP0003724_increased_susceptibility_to2.23046938
24MP0002452_abnormal_antigen_presenting2.19103731
25MP0005360_urolithiasis2.18324356
26MP0005365_abnormal_bile_salt2.18192278
27MP0002132_abnormal_respiratory_system2.15824478
28MP0002723_abnormal_immune_serum2.07223535
29MP0003186_abnormal_redox_activity1.96783100
30MP0004381_abnormal_hair_follicle1.96345035
31MP0003656_abnormal_erythrocyte_physiolo1.96238663
32MP0001819_abnormal_immune_cell1.95298181
33MP0002420_abnormal_adaptive_immunity1.93887075
34MP0009333_abnormal_splenocyte_physiolog1.93792666
35MP0002095_abnormal_skin_pigmentation1.93570550
36MP0001853_heart_inflammation1.82648339
37MP0005085_abnormal_gallbladder_physiolo1.81288938
38MP0001790_abnormal_immune_system1.77235407
39MP0005387_immune_system_phenotype1.77235407
40MP0010329_abnormal_lipoprotein_level1.76145572
41MP0008875_abnormal_xenobiotic_pharmacok1.75883608
42MP0001764_abnormal_homeostasis1.74115248
43MP0005397_hematopoietic_system_phenotyp1.72109850
44MP0001545_abnormal_hematopoietic_system1.72109850
45MP0001845_abnormal_inflammatory_respons1.69923782
46MP0008469_abnormal_protein_level1.68596440
47MP0003303_peritoneal_inflammation1.68553432
48MP0002398_abnormal_bone_marrow1.67831536
49MP0000371_diluted_coat_color1.67694820
50MP0005451_abnormal_body_composition1.64743803
51MP0000716_abnormal_immune_system1.59930403
52MP0001533_abnormal_skeleton_physiology1.58637064
53MP0002405_respiratory_system_inflammati1.56452224
54MP0000689_abnormal_spleen_morphology1.51534346
55MP0004510_myositis1.44039298
56MP0002429_abnormal_blood_cell1.42734865
57MP0002722_abnormal_immune_system1.42204993
58MP0003763_abnormal_thymus_physiology1.41121622
59MP0004947_skin_inflammation1.40674360
60MP0000749_muscle_degeneration1.40590616
61MP0002396_abnormal_hematopoietic_system1.37886665
62MP0005174_abnormal_tail_pigmentation1.37053917
63MP0000609_abnormal_liver_physiology1.36052828
64MP0000604_amyloidosis1.34033659
65MP0010155_abnormal_intestine_physiology1.28487802
66MP0003172_abnormal_lysosome_physiology1.25119712
67MP0009764_decreased_sensitivity_to1.24374923
68MP0006036_abnormal_mitochondrial_physio1.23932144
69MP0005584_abnormal_enzyme/coenzyme_acti1.18318035
70MP0008260_abnormal_autophagy1.18291823
71MP0005165_increased_susceptibility_to1.16349753
72MP0000343_altered_response_to1.16160695
73MP0002876_abnormal_thyroid_physiology1.15883535
74MP0000358_abnormal_cell_content/1.15031134
75MP0005319_abnormal_enzyme/_coenzyme1.14380177
76MP0009763_increased_sensitivity_to1.12783850
77MP0004233_abnormal_muscle_weight1.12614521
78MP0004147_increased_porphyrin_level1.09893758
79MP0000858_altered_metastatic_potential1.09111886
80MP0003183_abnormal_peptide_metabolism1.08870311
81MP0002166_altered_tumor_susceptibility1.07143418
82MP0005310_abnormal_salivary_gland1.06922945
83MP0005083_abnormal_biliary_tract1.06117220
84MP0000465_gastrointestinal_hemorrhage1.05749115
85MP0001186_pigmentation_phenotype1.02446619
86MP0002332_abnormal_exercise_endurance1.02126134
87MP0002118_abnormal_lipid_homeostasis1.01798615
88MP0002006_tumorigenesis1.00986336
89MP0003329_amyloid_beta_deposits1.00890443
90MP0005332_abnormal_amino_acid0.98905653
91MP0003075_altered_response_to0.98839068
92MP0003828_pulmonary_edema0.97989174
93MP0000747_muscle_weakness0.96351232
94MP0002933_joint_inflammation0.94173097
95MP0000598_abnormal_liver_morphology0.93659501
96MP0002075_abnormal_coat/hair_pigmentati0.92742158
97MP0004782_abnormal_surfactant_physiolog0.92736227
98MP0003950_abnormal_plasma_membrane0.90671256
99MP0006035_abnormal_mitochondrial_morpho0.89695636
100MP0001905_abnormal_dopamine_level0.89328692
101MP0003011_delayed_dark_adaptation0.88044924
102MP0005075_abnormal_melanosome_morpholog0.87293483
103MP0003866_abnormal_defecation0.86544366
104MP0005164_abnormal_response_to0.84307941
105MP0009643_abnormal_urine_homeostasis0.83907888
106MP0003646_muscle_fatigue0.83062331
107MP0000750_abnormal_muscle_regeneration0.82148158
108MP0008007_abnormal_cellular_replicative0.81962228
109MP0008873_increased_physiological_sensi0.81885451
110MP0001873_stomach_inflammation0.81784045
111MP0000703_abnormal_thymus_morphology0.81674477
112MP0001727_abnormal_embryo_implantation0.79969677
113MP0003448_altered_tumor_morphology0.78591886
114MP0005330_cardiomyopathy0.76695785
115MP0005166_decreased_susceptibility_to0.75756114
116MP0000249_abnormal_blood_vessel0.75634607
117MP0009765_abnormal_xenobiotic_induced0.75423949
118MP0000920_abnormal_myelination0.75109578
119MP0003300_gastrointestinal_ulcer0.73276545
120MP0003221_abnormal_cardiomyocyte_apopto0.72945040
121MP0001666_abnormal_nutrient_absorption0.71643594
122MP0001542_abnormal_bone_strength0.71618544
123MP0004883_abnormal_blood_vessel0.71403636
124MP0002019_abnormal_tumor_incidence0.70613094
125MP0009278_abnormal_bone_marrow0.70037355
126MP0002090_abnormal_vision0.69632603
127MP0003786_premature_aging0.68940027
128MP0009642_abnormal_blood_homeostasis0.68264075
129MP0001851_eye_inflammation0.67111192
130MP0005376_homeostasis/metabolism_phenot0.66560409
131MP0002138_abnormal_hepatobiliary_system0.66014987

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.13233560
2Recurrent abscess formation (HP:0002722)4.08917193
3Recurrent bacterial skin infections (HP:0005406)3.87826670
4Recurrent gram-negative bacterial infections (HP:0005420)3.86557402
5Eczematoid dermatitis (HP:0000976)3.86532073
6Petechiae (HP:0000967)3.60420978
7Abnormal mitochondria in muscle tissue (HP:0008316)3.57880811
8Myositis (HP:0100614)3.48506322
9Acute necrotizing encephalopathy (HP:0006965)3.44112494
10Systemic lupus erythematosus (HP:0002725)3.40708326
11Vacuolated lymphocytes (HP:0001922)3.35349406
12Increased cerebral lipofuscin (HP:0011813)3.20447617
13Abnormality of macrophages (HP:0004311)3.17056244
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.15884882
15Increased intramyocellular lipid droplets (HP:0012240)3.05306500
16Hypokinesia (HP:0002375)3.02728697
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.98914281
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.98914281
19Thrombocytosis (HP:0001894)2.98361294
20Progressive macrocephaly (HP:0004481)2.93955986
21Acute encephalopathy (HP:0006846)2.88453718
22Abnormality of aromatic amino acid family metabolism (HP:0004338)2.85911816
23Purpura (HP:0000979)2.85705338
24Orchitis (HP:0100796)2.80905001
25Recurrent skin infections (HP:0001581)2.79436127
26Ocular albinism (HP:0001107)2.76037153
27Amyloidosis (HP:0011034)2.72509877
28Type I transferrin isoform profile (HP:0003642)2.71868837
29Hepatosplenomegaly (HP:0001433)2.66501962
30Patchy hypopigmentation of hair (HP:0011365)2.65026517
31Abnormality of fatty-acid metabolism (HP:0004359)2.60987116
32Hepatic necrosis (HP:0002605)2.60404363
33Hypobetalipoproteinemia (HP:0003563)2.58028576
34Autoimmune thrombocytopenia (HP:0001973)2.56735593
35Hyperlipoproteinemia (HP:0010980)2.55470890
36Hepatocellular necrosis (HP:0001404)2.54462989
37Prolonged partial thromboplastin time (HP:0003645)2.53573893
38Exercise intolerance (HP:0003546)2.52030617
39Complement deficiency (HP:0004431)2.51254296
40Optic neuritis (HP:0100653)2.50631868
41Retrobulbar optic neuritis (HP:0100654)2.50631868
42Vertebral compression fractures (HP:0002953)2.50219015
43Xanthomatosis (HP:0000991)2.43535723
44Abnormality of glycolysis (HP:0004366)2.41391554
45Increased serum pyruvate (HP:0003542)2.41391554
46Rhabdomyolysis (HP:0003201)2.39753024
47Axonal loss (HP:0003447)2.39720886
48Abnormal platelet function (HP:0011869)2.38517869
49Impaired platelet aggregation (HP:0003540)2.38517869
50Abnormality of monocarboxylic acid metabolism (HP:0010996)2.37865646
51Recurrent fungal infections (HP:0002841)2.37435362
52Epistaxis (HP:0000421)2.36073723
53Lactic acidosis (HP:0003128)2.33446400
54Abnormality of liposaccharide metabolism (HP:0010968)2.32379185
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.32379185
56Abnormality of glycolipid metabolism (HP:0010969)2.32379185
57Mediastinal lymphadenopathy (HP:0100721)2.31720873
58Agnosia (HP:0010524)2.29485647
59Deep venous thrombosis (HP:0002625)2.29321652
60Iris hypopigmentation (HP:0007730)2.28818088
61Pustule (HP:0200039)2.27587116
62Leukocytosis (HP:0001974)2.27290820
63Increased IgM level (HP:0003496)2.26796155
64White forelock (HP:0002211)2.26094238
65Vasculitis (HP:0002633)2.25704641
66Ragged-red muscle fibers (HP:0003200)2.25559353
67Cerebral edema (HP:0002181)2.24364817
68Albinism (HP:0001022)2.23796464
69Urticaria (HP:0001025)2.22986893
70Gingival bleeding (HP:0000225)2.21336812
71Keratoconjunctivitis sicca (HP:0001097)2.20869265
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20857680
73Gastrointestinal stroma tumor (HP:0100723)2.20343856
74Reduced antithrombin III activity (HP:0001976)2.19835734
75Abnormal pupillary function (HP:0007686)2.19111267
76Abnormal protein glycosylation (HP:0012346)2.18700827
77Abnormal glycosylation (HP:0012345)2.18700827
78Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18700827
79Abnormal protein N-linked glycosylation (HP:0012347)2.18700827
80Glomerulonephritis (HP:0000099)2.18485382
81Joint hemorrhage (HP:0005261)2.17886949
82Cutaneous melanoma (HP:0012056)2.17742768
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.17551840
84Combined immunodeficiency (HP:0005387)2.15184460
853-Methylglutaconic aciduria (HP:0003535)2.13252558
86Increased serum lactate (HP:0002151)2.13198433
87Heterochromia iridis (HP:0001100)2.12837272
88Abnormality of complement system (HP:0005339)2.12125387
89Respiratory failure (HP:0002878)2.11760882
90Aplastic anemia (HP:0001915)2.11586350
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10144177
92Prostate neoplasm (HP:0100787)2.09501101
93Loss of speech (HP:0002371)2.09279924
94Emotional lability (HP:0000712)2.08779490
95Muscle fibrillation (HP:0010546)2.08595430
96Fatigue (HP:0012378)2.07928522
97Rough bone trabeculation (HP:0100670)2.07480607
98Abnormality of the anterior horn cell (HP:0006802)2.07361170
99Degeneration of anterior horn cells (HP:0002398)2.07361170
100Abnormal gallbladder physiology (HP:0012438)2.06780339
101Cholecystitis (HP:0001082)2.06780339
102Renal Fanconi syndrome (HP:0001994)2.06374542
103Keratoconjunctivitis (HP:0001096)2.06241309
104Poor head control (HP:0002421)2.06033540
105Progressive neurologic deterioration (HP:0002344)2.06015756
106Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05819204
107Distal lower limb muscle weakness (HP:0009053)2.05734416
108Agammaglobulinemia (HP:0004432)2.04852873
109Hypertensive crisis (HP:0100735)2.04636417
110IgM deficiency (HP:0002850)2.04043715
111Prolonged bleeding time (HP:0003010)2.03645978
112Cholelithiasis (HP:0001081)2.03490487
113Opisthotonus (HP:0002179)2.03223779
114Prolonged neonatal jaundice (HP:0006579)2.02672969
115Chronic obstructive pulmonary disease (HP:0006510)2.01225299
116Obstructive lung disease (HP:0006536)2.01225299
117Stomatitis (HP:0010280)2.00742128
118Severe combined immunodeficiency (HP:0004430)1.99224720
119Abnormality of eosinophils (HP:0001879)1.98850384
120Hypergammaglobulinemia (HP:0010702)1.97962673
121Exertional dyspnea (HP:0002875)1.97883772
122Myocardial infarction (HP:0001658)1.97695947
123Recurrent viral infections (HP:0004429)1.97538302
124Respiratory difficulties (HP:0002880)1.97431337
125Meningitis (HP:0001287)1.97327361
126Spastic paraparesis (HP:0002313)1.96360296
127Interstitial pulmonary disease (HP:0006530)1.96136777
128Panhypogammaglobulinemia (HP:0003139)1.96049409
129Generalized hypopigmentation (HP:0007513)1.95953815
130Microvesicular hepatic steatosis (HP:0001414)1.95480598
131Abnormality of the heme biosynthetic pathway (HP:0010472)1.95278019
132Mitochondrial inheritance (HP:0001427)1.94178097
133Premature graying of hair (HP:0002216)1.92603945
134Increased muscle lipid content (HP:0009058)1.92462244
135Tongue fasciculations (HP:0001308)1.92186174
136Acute hepatic failure (HP:0006554)1.92156599
137Increased hepatocellular lipid droplets (HP:0006565)1.90976040
138Increased serum ferritin (HP:0003281)1.90484422
139Nausea (HP:0002018)1.89884200
140Encephalitis (HP:0002383)1.89756979
141Gastrointestinal infarctions (HP:0005244)1.89663536
142Lipid accumulation in hepatocytes (HP:0006561)1.89619220
143Hyperammonemia (HP:0001987)1.87886659
144Muscle fiber atrophy (HP:0100295)1.87378118
145Nonimmune hydrops fetalis (HP:0001790)1.87093720
146Increased CSF lactate (HP:0002490)1.86427734
147Dysostosis multiplex (HP:0000943)1.86259841
148Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.85914575
149Nemaline bodies (HP:0003798)1.85732852
150Arterial thrombosis (HP:0004420)1.85383037
151Cellulitis (HP:0100658)1.85100365
152IgG deficiency (HP:0004315)1.84504108
153Chronic otitis media (HP:0000389)1.84395282
154Recurrent cutaneous fungal infections (HP:0011370)1.84155852
155Type 2 muscle fiber atrophy (HP:0003554)1.83921959
156Orthostatic hypotension (HP:0001278)1.82165750
157Myoglobinuria (HP:0002913)1.81416025
158Episodic fever (HP:0001954)1.80514604
159Abnormal gallbladder morphology (HP:0012437)1.74303958
160Generalized aminoaciduria (HP:0002909)1.71241309
161Amniotic constriction ring (HP:0009775)1.70962257
162Abnormality of placental membranes (HP:0011409)1.70962257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.26461750
2PIK3CG3.19156233
3VRK23.08419453
4MAP4K13.08041889
5KIT2.88375813
6TBK12.66303489
7SCYL22.64110119
8LIMK12.63130512
9PIM22.53681510
10IRAK42.52294680
11ZAP702.48774997
12TESK22.38572559
13TXK2.24072703
14TYK22.18996640
15BCKDK2.17784100
16MAP3K142.08244722
17BUB12.04811831
18PBK2.04179083
19RIPK41.95771725
20NME21.85472951
21MAP3K121.83713300
22CSF1R1.80953408
23KDR1.78924767
24ARAF1.75789261
25ERN11.68516881
26SYK1.64947901
27CCNB11.62886088
28IRAK31.61254723
29MAP2K31.52482083
30IKBKE1.50523327
31RPS6KA41.48809942
32NEK91.39018904
33FLT31.37865015
34STK161.37770305
35EIF2AK11.37511380
36GRK61.34502333
37IKBKB1.34238140
38TRIB31.28829220
39BTK1.25251176
40MATK1.23198450
41MYLK1.21348328
42PDK21.18769749
43TSSK61.17470850
44JAK31.17427016
45TEC1.17180645
46DAPK31.13457517
47MARK31.11146046
48TLK11.07595193
49SRPK11.04610090
50DAPK11.04399483
51WEE11.04108018
52CASK1.03899833
53CAMKK21.03512528
54EPHA21.02954102
55SIK20.99508384
56ILK0.97597694
57PIM10.91081480
58JAK10.90096363
59LCK0.89643420
60ITK0.87289745
61BRAF0.87064661
62TAOK20.86748871
63ABL20.86210690
64MAP3K100.85946957
65NEK10.85089658
66MOS0.84125434
67LRRK20.83893433
68LYN0.83068991
69SIK30.82229654
70FGFR40.80235670
71EIF2AK30.78977309
72CLK10.78408991
73MAPKAPK30.77995501
74MUSK0.76021625
75EPHB10.75972969
76RPS6KB20.74289647
77TESK10.73768100
78JAK20.71174948
79BRSK20.68270614
80DAPK20.67603620
81STK100.66836691
82FGR0.66187657
83PRKG20.65190572
84MAPK40.64762763
85MAPK120.64527893
86CHUK0.64267865
87MAP2K60.64132077
88PRKCD0.63537432
89RAF10.63340897
90MAP4K20.62282281
91CDK190.62031775
92MAPKAPK20.61458569
93CSK0.60314014
94MST40.58703239
95MAP3K110.57247661
96RPS6KA60.56483176
97CDK80.54529870
98FES0.53509768
99GRK70.53312638
100LMTK20.53140294
101MAP3K10.51108509
102MAP2K40.50616863
103CAMK2G0.49910523
104PRKCI0.49026088
105PAK10.48694468
106PDPK10.48374371
107ADRBK20.47888909
108TAOK30.47357015
109CAMK2D0.47040231
110HCK0.44980938
111PAK60.43609376
112CDK70.43171142
113SIK10.42178389
114MAP3K50.41324703
115MAPK70.40724428
116PAK40.40636882
117TNK20.40480536
118MAPK110.40363130
119MINK10.39982189
120PTK2B0.38992894
121TGFBR20.38456010
122MAP2K10.38100657
123NME10.37445535
124BRSK10.36602664
125PHKG10.36533715
126PHKG20.36533715
127RPS6KC10.36449283
128RPS6KL10.36449283
129DYRK30.35407317
130CSNK1G30.34682251
131PDK10.34623127
132GRK50.34396753
133FER0.33722318
134BMPR20.33649310
135MAP2K70.33365459
136MAP3K30.32924655

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.34315599
2Vitamin B6 metabolism_Homo sapiens_hsa007502.78999272
3Staphylococcus aureus infection_Homo sapiens_hsa051502.62093719
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.36540081
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.02331793
6Alzheimers disease_Homo sapiens_hsa050101.93529717
7Vibrio cholerae infection_Homo sapiens_hsa051101.89690242
8Sulfur metabolism_Homo sapiens_hsa009201.89183046
9Pentose and glucuronate interconversions_Homo sapiens_hsa000401.86273442
10Primary immunodeficiency_Homo sapiens_hsa053401.85095306
11Ribosome_Homo sapiens_hsa030101.81922439
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80717354
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78980855
14Leishmaniasis_Homo sapiens_hsa051401.73934009
15Huntingtons disease_Homo sapiens_hsa050161.70470775
16Complement and coagulation cascades_Homo sapiens_hsa046101.61217018
17Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.59324061
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.58771160
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52436297
20RNA polymerase_Homo sapiens_hsa030201.48691932
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.47867420
22Folate biosynthesis_Homo sapiens_hsa007901.40911473
23Peroxisome_Homo sapiens_hsa041461.39171592
24Lysosome_Homo sapiens_hsa041421.34655331
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34274592
26Galactose metabolism_Homo sapiens_hsa000521.33842414
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.33586381
28Histidine metabolism_Homo sapiens_hsa003401.31474101
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30713593
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.29294965
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28638725
32Pentose phosphate pathway_Homo sapiens_hsa000301.27293538
33Pertussis_Homo sapiens_hsa051331.25834549
34Oxidative phosphorylation_Homo sapiens_hsa001901.24430426
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21615352
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21557676
37Legionellosis_Homo sapiens_hsa051341.21356481
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21108041
39Allograft rejection_Homo sapiens_hsa053301.18103741
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16146167
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14966721
42Antigen processing and presentation_Homo sapiens_hsa046121.14486574
43Other glycan degradation_Homo sapiens_hsa005111.14164263
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13989417
45Fatty acid degradation_Homo sapiens_hsa000711.11646507
46Chemical carcinogenesis_Homo sapiens_hsa052041.11323142
47Nucleotide excision repair_Homo sapiens_hsa034201.10954220
48Rheumatoid arthritis_Homo sapiens_hsa053231.08508005
49beta-Alanine metabolism_Homo sapiens_hsa004101.07797577
50Phagosome_Homo sapiens_hsa041451.07493541
51Measles_Homo sapiens_hsa051621.06502523
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06068479
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.06050344
54Phenylalanine metabolism_Homo sapiens_hsa003601.05260652
55Carbon metabolism_Homo sapiens_hsa012001.04946252
56Type I diabetes mellitus_Homo sapiens_hsa049401.04868556
57N-Glycan biosynthesis_Homo sapiens_hsa005101.03204037
58Tuberculosis_Homo sapiens_hsa051521.02555158
59Osteoclast differentiation_Homo sapiens_hsa043801.00230058
60Viral myocarditis_Homo sapiens_hsa054161.00146384
61Hematopoietic cell lineage_Homo sapiens_hsa046400.98864453
62Graft-versus-host disease_Homo sapiens_hsa053320.98367317
63Pyruvate metabolism_Homo sapiens_hsa006200.96840189
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95912283
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95622802
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95292973
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95250307
68Biosynthesis of amino acids_Homo sapiens_hsa012300.94505481
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93801213
70B cell receptor signaling pathway_Homo sapiens_hsa046620.92879741
71Arginine biosynthesis_Homo sapiens_hsa002200.92334029
72Pyrimidine metabolism_Homo sapiens_hsa002400.92043665
73PPAR signaling pathway_Homo sapiens_hsa033200.92009057
74Parkinsons disease_Homo sapiens_hsa050120.90951514
75Apoptosis_Homo sapiens_hsa042100.86561044
76Tryptophan metabolism_Homo sapiens_hsa003800.86355257
77Sulfur relay system_Homo sapiens_hsa041220.86297892
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86272074
79Glutathione metabolism_Homo sapiens_hsa004800.86020504
80Collecting duct acid secretion_Homo sapiens_hsa049660.85285517
81Shigellosis_Homo sapiens_hsa051310.80804142
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79768995
83Epstein-Barr virus infection_Homo sapiens_hsa051690.79191789
84Asthma_Homo sapiens_hsa053100.78028987
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77565286
86Fructose and mannose metabolism_Homo sapiens_hsa000510.76862320
87Base excision repair_Homo sapiens_hsa034100.76388680
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76121793
89Caffeine metabolism_Homo sapiens_hsa002320.76117110
90Endocytosis_Homo sapiens_hsa041440.75632791
91Fatty acid elongation_Homo sapiens_hsa000620.75294824
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75257916
93DNA replication_Homo sapiens_hsa030300.74007461
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71754224
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.71497115
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71359139
97Retinol metabolism_Homo sapiens_hsa008300.70316883
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68273524
99Influenza A_Homo sapiens_hsa051640.67323003
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66462752
101Mismatch repair_Homo sapiens_hsa034300.66364741
102Propanoate metabolism_Homo sapiens_hsa006400.65871719
103Tyrosine metabolism_Homo sapiens_hsa003500.65401975
104Purine metabolism_Homo sapiens_hsa002300.64929404
105Acute myeloid leukemia_Homo sapiens_hsa052210.61433678
106Regulation of autophagy_Homo sapiens_hsa041400.60776914
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.60388287
108Protein export_Homo sapiens_hsa030600.59334048
109Cardiac muscle contraction_Homo sapiens_hsa042600.59137888
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58541772
111Synaptic vesicle cycle_Homo sapiens_hsa047210.56667515
112Spliceosome_Homo sapiens_hsa030400.56337420
113Salmonella infection_Homo sapiens_hsa051320.56194409
114Autoimmune thyroid disease_Homo sapiens_hsa053200.55609896
115Metabolic pathways_Homo sapiens_hsa011000.54370700
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53549462
117Herpes simplex infection_Homo sapiens_hsa051680.52423763
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51379859
119Toxoplasmosis_Homo sapiens_hsa051450.50861024
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49884103
121Fatty acid metabolism_Homo sapiens_hsa012120.48495806
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43078412
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38548868
124Homologous recombination_Homo sapiens_hsa034400.37043301
125Malaria_Homo sapiens_hsa051440.34487825

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