RTEL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.32811731
2nuclear pore complex assembly (GO:0051292)5.06033416
3nuclear pore organization (GO:0006999)5.00783956
4DNA unwinding involved in DNA replication (GO:0006268)5.00585319
5DNA replication initiation (GO:0006270)4.73456715
6DNA strand elongation involved in DNA replication (GO:0006271)4.65385291
7mitotic sister chromatid segregation (GO:0000070)4.56666536
8protein localization to chromosome, centromeric region (GO:0071459)4.53566060
9mitotic chromosome condensation (GO:0007076)4.52838907
10DNA replication-dependent nucleosome assembly (GO:0006335)4.42422547
11DNA replication-dependent nucleosome organization (GO:0034723)4.42422547
12DNA strand elongation (GO:0022616)4.41913079
13sister chromatid segregation (GO:0000819)4.40996082
14mitotic nuclear envelope disassembly (GO:0007077)4.37158508
15telomere maintenance via semi-conservative replication (GO:0032201)4.27367545
16mitotic metaphase plate congression (GO:0007080)4.23193364
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.15610579
18DNA replication checkpoint (GO:0000076)4.14265117
19kinetochore organization (GO:0051383)4.11073068
20membrane disassembly (GO:0030397)4.08310270
21nuclear envelope disassembly (GO:0051081)4.08310270
22Golgi transport vesicle coating (GO:0048200)4.01555621
23COPI coating of Golgi vesicle (GO:0048205)4.01555621
24mitotic recombination (GO:0006312)3.91225735
25telomere maintenance via recombination (GO:0000722)3.90153105
26mannose metabolic process (GO:0006013)3.89855732
27pore complex assembly (GO:0046931)3.87869136
28regulation of spindle organization (GO:0090224)3.87245050
29nucleobase biosynthetic process (GO:0046112)3.85369776
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.84984898
31negative regulation of erythrocyte differentiation (GO:0045647)3.83758749
32folic acid-containing compound biosynthetic process (GO:0009396)3.77304284
33* DNA geometric change (GO:0032392)3.77038896
34* DNA duplex unwinding (GO:0032508)3.76299623
35IMP biosynthetic process (GO:0006188)3.74614813
36negative regulation of histone methylation (GO:0031061)3.73656471
37metaphase plate congression (GO:0051310)3.72564751
38regulation of histone H3-K9 methylation (GO:0051570)3.69906692
39proline biosynthetic process (GO:0006561)3.69489490
40positive regulation of chromosome segregation (GO:0051984)3.68687391
41kinetochore assembly (GO:0051382)3.67457214
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.62047728
43somatic hypermutation of immunoglobulin genes (GO:0016446)3.61686150
44somatic diversification of immune receptors via somatic mutation (GO:0002566)3.61686150
45mitotic sister chromatid cohesion (GO:0007064)3.61120193
46translesion synthesis (GO:0019985)3.55449102
47attachment of spindle microtubules to kinetochore (GO:0008608)3.55004459
48chromatin remodeling at centromere (GO:0031055)3.54493483
49regulation of mammary gland epithelial cell proliferation (GO:0033599)3.53773702
50focal adhesion assembly (GO:0048041)3.53503691
51cell-substrate adherens junction assembly (GO:0007045)3.53503691
52regulation of chromosome segregation (GO:0051983)3.52720793
53regulation of sister chromatid cohesion (GO:0007063)3.50305313
54regulation of centrosome cycle (GO:0046605)3.49894377
55purine nucleobase biosynthetic process (GO:0009113)3.47678036
56CENP-A containing nucleosome assembly (GO:0034080)3.47116993
57pre-miRNA processing (GO:0031054)3.46240153
58DNA replication-independent nucleosome organization (GO:0034724)3.45947360
59DNA replication-independent nucleosome assembly (GO:0006336)3.45947360
60telomere maintenance via telomere lengthening (GO:0010833)3.45943077
61activation of Rac GTPase activity (GO:0032863)3.45884366
62spliceosomal tri-snRNP complex assembly (GO:0000244)3.45485630
63regulation of histone H3-K27 methylation (GO:0061085)3.45443544
64regulation of centriole replication (GO:0046599)3.44223415
65adherens junction assembly (GO:0034333)3.43811327
66heterochromatin organization (GO:0070828)3.42409585
67pinocytosis (GO:0006907)3.42186262
68apoptotic process involved in morphogenesis (GO:0060561)3.41730624
69regulation of mitotic spindle organization (GO:0060236)3.41283752
70formation of translation preinitiation complex (GO:0001731)3.41244354
71negative regulation of chromosome segregation (GO:0051985)3.40887798
72establishment of chromosome localization (GO:0051303)3.40455311
73positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.37778944
74meiotic chromosome segregation (GO:0045132)3.37323709
75chromatin assembly or disassembly (GO:0006333)3.37070186
76negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.36186262
77protein localization to chromosome (GO:0034502)3.33898267
78spindle checkpoint (GO:0031577)3.33710050
79chromosome condensation (GO:0030261)3.33388091
80* DNA conformation change (GO:0071103)3.32368899
81negative regulation of cell size (GO:0045792)3.30957626
82chromosome segregation (GO:0007059)3.30576863
83protein K6-linked ubiquitination (GO:0085020)3.30349623
84negative regulation of mitotic sister chromatid separation (GO:2000816)3.28262835
85negative regulation of mitotic sister chromatid segregation (GO:0033048)3.28262835
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.28262835
87negative regulation of sister chromatid segregation (GO:0033046)3.28262835
88spindle assembly checkpoint (GO:0071173)3.27188845
89dosage compensation (GO:0007549)3.25599874
90regulation of mitotic metaphase/anaphase transition (GO:0030071)3.24329995
91protein retention in ER lumen (GO:0006621)3.23906026
92positive regulation of mitotic sister chromatid separation (GO:1901970)3.23767524
93positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.23767524
94positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.23767524
95regulation of translational fidelity (GO:0006450)3.23712609
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.23576339
97regulation of posttranscriptional gene silencing (GO:0060147)3.23491668
98regulation of gene silencing by miRNA (GO:0060964)3.23491668
99regulation of gene silencing by RNA (GO:0060966)3.23491668
100postreplication repair (GO:0006301)3.21407126
101nuclear envelope organization (GO:0006998)3.20156926
102chromatin assembly (GO:0031497)3.19972141
103histone exchange (GO:0043486)3.19631359
104mitotic spindle assembly checkpoint (GO:0007094)3.17705807
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16929676
106regulation of nuclear cell cycle DNA replication (GO:0033262)3.16668092
107mismatch repair (GO:0006298)3.16660937
108regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.15661937
109mitotic spindle checkpoint (GO:0071174)3.15610881
110embryonic process involved in female pregnancy (GO:0060136)3.14099810
111maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.13947927
112IMP metabolic process (GO:0046040)3.12491366
113DNA topological change (GO:0006265)3.12111588
114regulation of mitotic sister chromatid separation (GO:0010965)3.11476152
115regulation of mitotic sister chromatid segregation (GO:0033047)3.11476152
116regulation of sister chromatid segregation (GO:0033045)3.11476152
117positive regulation of Cdc42 GTPase activity (GO:0043089)3.11011142
118DNA packaging (GO:0006323)3.08241277
119ribosome biogenesis (GO:0042254)3.04770959
120ribosome assembly (GO:0042255)3.01875662
121cell-substrate junction assembly (GO:0007044)3.01352694
122retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.98573141
123intracellular estrogen receptor signaling pathway (GO:0030520)2.96225119
124cellular response to epidermal growth factor stimulus (GO:0071364)2.92844174
125regulation of RNA export from nucleus (GO:0046831)2.91865611
126protein localization to endosome (GO:0036010)2.91492843
127pentose-phosphate shunt (GO:0006098)2.87510700
128regulation of nucleobase-containing compound transport (GO:0032239)2.85357579
129activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.83587536
130positive regulation of nuclease activity (GO:0032075)2.81554992
131semaphorin-plexin signaling pathway (GO:0071526)2.80528269
132basement membrane organization (GO:0071711)2.78574670
133regulation of cholesterol homeostasis (GO:2000188)2.76105219
134modulation by symbiont of host cellular process (GO:0044068)2.72830707
135proline metabolic process (GO:0006560)2.72368216
136regulation of type I interferon-mediated signaling pathway (GO:0060338)2.71349296
137cellular response to virus (GO:0098586)2.68378759
138snRNA metabolic process (GO:0016073)2.65778874
139glucocorticoid receptor signaling pathway (GO:0042921)2.64793316
140low-density lipoprotein particle clearance (GO:0034383)2.63595171
141modulation by virus of host process (GO:0019054)2.63457829
142positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.62836491
143GDP-mannose metabolic process (GO:0019673)2.62807024
144regulation of early endosome to late endosome transport (GO:2000641)2.62555610
1453-UTR-mediated mRNA stabilization (GO:0070935)2.59810708
146RNA stabilization (GO:0043489)2.56774610
147mRNA stabilization (GO:0048255)2.56774610
148folic acid metabolic process (GO:0046655)2.55591862
149cytoskeletal anchoring at plasma membrane (GO:0007016)2.55557898
150regulation of nuclease activity (GO:0032069)2.55438417
151glucose catabolic process (GO:0006007)2.55271991
152regulation of glucose import in response to insulin stimulus (GO:2001273)2.54912166
153positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.53941876
154mitotic G1 DNA damage checkpoint (GO:0031571)2.53887057
155peptidyl-arginine omega-N-methylation (GO:0035247)2.53158893
156regulation of ARF GTPase activity (GO:0032312)2.51058920
157negative regulation of viral release from host cell (GO:1902187)2.49165690
158NADPH regeneration (GO:0006740)2.49080550
159glucose 6-phosphate metabolic process (GO:0051156)2.47613758
160negative regulation of fatty acid transport (GO:2000192)2.46706577
161maternal placenta development (GO:0001893)2.46270864
162regulation of NFAT protein import into nucleus (GO:0051532)2.45892647
163endoplasmic reticulum unfolded protein response (GO:0030968)2.45076703
164mitochondrial DNA metabolic process (GO:0032042)2.45001011
165response to epidermal growth factor (GO:0070849)2.44610742
166epithelial cell-cell adhesion (GO:0090136)2.43800326
167regulation of cholesterol biosynthetic process (GO:0045540)2.43467633
168protein export from nucleus (GO:0006611)2.42796246
169planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40870242
170T cell apoptotic process (GO:0070231)2.39970181
171mitotic G1/S transition checkpoint (GO:0044819)2.39433248
172histone H3-K36 demethylation (GO:0070544)2.38004111
173negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.37855817
174ER-nucleus signaling pathway (GO:0006984)2.37732702
175corticosteroid receptor signaling pathway (GO:0031958)2.37013497
176modulation by virus of host morphology or physiology (GO:0019048)2.36883386
177stress fiber assembly (GO:0043149)2.35876506
178barbed-end actin filament capping (GO:0051016)2.35356943
179response to laminar fluid shear stress (GO:0034616)2.34273610
180positive regulation of blood vessel endothelial cell migration (GO:0043536)2.32633288
181protein-DNA complex disassembly (GO:0032986)2.32478585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.55025605
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.17173577
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.71384195
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.48031708
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87274534
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82832267
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.74843449
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56253365
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.44789236
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38373661
11LXR_22292898_ChIP-Seq_THP-1_Human2.37172769
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.35098979
13AR_21909140_ChIP-Seq_LNCAP_Human2.34309569
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.32947284
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31959523
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.30182660
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23514661
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17806197
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15102983
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05446380
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02709137
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01646127
23E2F7_22180533_ChIP-Seq_HELA_Human10.7929365
24XRN2_22483619_ChIP-Seq_HELA_Human1.99061180
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98157473
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97682544
27* ETS1_20019798_ChIP-Seq_JURKAT_Human1.96404925
28MYC_22102868_ChIP-Seq_BL_Human1.96344923
29* TCF7_22412390_ChIP-Seq_EML_Mouse1.95359590
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93961203
31RACK7_27058665_Chip-Seq_MCF-7_Human1.93486262
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93086612
33ZNF263_19887448_ChIP-Seq_K562_Human1.91869508
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91500955
35* EST1_17652178_ChIP-ChIP_JURKAT_Human1.90397345
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87208422
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85031062
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.82868171
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79736543
40* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78019118
41CIITA_25753668_ChIP-Seq_RAJI_Human1.77307623
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74771088
43KDM2B_26808549_Chip-Seq_DND41_Human1.73962910
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72814323
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71113793
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70884100
47* VDR_23849224_ChIP-Seq_CD4+_Human1.63917088
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59007708
49* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58304313
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57694183
51* FOXP3_21729870_ChIP-Seq_TREG_Human1.57670361
52* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54502200
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.53167615
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50761922
55KDM5A_27292631_Chip-Seq_BREAST_Human1.49365240
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49126793
57P68_20966046_ChIP-Seq_HELA_Human1.48744705
58VDR_24763502_ChIP-Seq_THP-1_Human1.47310785
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47057394
60TTF2_22483619_ChIP-Seq_HELA_Human1.46973117
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.46701302
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46060956
63* GABP_19822575_ChIP-Seq_HepG2_Human1.45367501
64DCP1A_22483619_ChIP-Seq_HELA_Human1.45074027
65MAF_26560356_Chip-Seq_TH1_Human1.44447692
66* TET1_21451524_ChIP-Seq_MESCs_Mouse1.41180331
67KDM2B_26808549_Chip-Seq_K562_Human1.39657665
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38326637
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38275168
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36958095
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36927320
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36563382
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34197757
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34195505
75NCOR1_26117541_ChIP-Seq_K562_Human1.34117797
76MAF_26560356_Chip-Seq_TH2_Human1.33716917
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32205070
78UTX_26944678_Chip-Seq_JUKART_Human1.30780103
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30069944
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29017142
81* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28648563
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28392398
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28100139
84* SMC4_20622854_ChIP-Seq_HELA_Human1.27225125
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27132758
86* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26447204
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.25385848
88ATF3_27146783_Chip-Seq_COLON_Human1.24905237
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24048447
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23658657
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.23338482
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23021252
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22186816
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21494151
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.21318936
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21134576
97KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20846944
98KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20846944
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20846944
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20429154
101YY1_21170310_ChIP-Seq_MESCs_Mouse1.20006085
102* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19589974
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19285434
104TP53_22127205_ChIP-Seq_IMR90_Human1.19061072
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18782959
106GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18697068
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18641094
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18549848
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17108542
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16847167
111ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16718809
112ELF1_20517297_ChIP-Seq_JURKAT_Human1.15252124
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14925503
114NANOG_21062744_ChIP-ChIP_HESCs_Human1.14762212
115SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14482877
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13723737
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13608718
118VDR_21846776_ChIP-Seq_THP-1_Human1.13590087
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13575229
120CREB1_26743006_Chip-Seq_LNCaP_Human1.13541104
121CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13330832
122CLOCK_20551151_ChIP-Seq_293T_Human1.13327654
123ESR2_21235772_ChIP-Seq_MCF-7_Human1.11965761
124* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11056651
125ELK1_19687146_ChIP-ChIP_HELA_Human1.09643522
126TCF3_18692474_ChIP-Seq_MESCs_Mouse1.09156400
127TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08267192
128TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07860934
129KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07338524
130RUNX1_27514584_Chip-Seq_MCF-7_Human1.06272212
131TFEB_21752829_ChIP-Seq_HELA_Human1.06119031
132PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04933291
133MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04721045
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04691082
135BCOR_27268052_Chip-Seq_Bcells_Human1.04460969
136ERG_21242973_ChIP-ChIP_JURKAT_Human1.04388407
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03460582
138RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02387448
139* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01473869
140PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01225840
141RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99747671
142* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98733263
143SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98519699
144MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98378332
145CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97773491
146NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97591655
147PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97567702
148SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97382000
149GATA1_19941827_ChIP-Seq_MEL_Mouse0.97204600
150HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96733436
151NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96344387
152SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94666009
153HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93569403
154CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91560228
155ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90124115
156ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89817991
157SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88525610
158SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88120522
159SOX2_18692474_ChIP-Seq_MESCs_Mouse0.84872518
160ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84634754
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84565934
162NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81927734
163* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.78835654
164SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78447724
165* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78305440
166POU5F1_16518401_ChIP-PET_MESCs_Mouse0.78305160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.96527801
2MP0003111_abnormal_nucleus_morphology4.89721862
3MP0003693_abnormal_embryo_hatching4.67752694
4MP0008057_abnormal_DNA_replication4.30714353
5MP0003077_abnormal_cell_cycle4.02500596
6MP0004957_abnormal_blastocyst_morpholog3.96088788
7MP0005451_abnormal_body_composition3.94140269
8MP0005058_abnormal_lysosome_morphology3.45301266
9MP0008058_abnormal_DNA_repair2.95528291
10MP0010352_gastrointestinal_tract_polyps2.77222673
11MP0002877_abnormal_melanocyte_morpholog2.69872374
12MP0008007_abnormal_cellular_replicative2.65722902
13MP0001730_embryonic_growth_arrest2.64765349
14MP0003123_paternal_imprinting2.47746234
15MP0003172_abnormal_lysosome_physiology2.44087388
16MP0004185_abnormal_adipocyte_glucose2.43555749
17MP0000350_abnormal_cell_proliferation2.40398155
18MP0010307_abnormal_tumor_latency2.38717344
19MP0008932_abnormal_embryonic_tissue2.38108219
20MP0008877_abnormal_DNA_methylation2.30936802
21MP0008260_abnormal_autophagy2.22512708
22MP0001672_abnormal_embryogenesis/_devel2.10311780
23MP0005380_embryogenesis_phenotype2.10311780
24MP0009840_abnormal_foam_cell1.96866993
25MP0003890_abnormal_embryonic-extraembry1.93903245
26MP0003984_embryonic_growth_retardation1.89671591
27* MP0001697_abnormal_embryo_size1.88644237
28MP0002088_abnormal_embryonic_growth/wei1.86328377
29MP0003786_premature_aging1.85981663
30MP0004197_abnormal_fetal_growth/weight/1.85935479
31* MP0002085_abnormal_embryonic_tissue1.85288299
32* MP0002084_abnormal_developmental_patter1.82999886
33MP0008438_abnormal_cutaneous_collagen1.82766678
34MP0003453_abnormal_keratinocyte_physiol1.81799189
35MP0002396_abnormal_hematopoietic_system1.79213973
36* MP0002086_abnormal_extraembryonic_tissu1.75240488
37* MP0002080_prenatal_lethality1.73321491
38MP0003121_genomic_imprinting1.71053432
39MP0000003_abnormal_adipose_tissue1.66443935
40MP0003705_abnormal_hypodermis_morpholog1.65359008
41MP0003436_decreased_susceptibility_to1.64746477
42MP0000858_altered_metastatic_potential1.63233987
43MP0001348_abnormal_lacrimal_gland1.59642572
44MP0003091_abnormal_cell_migration1.51938646
45MP0005409_darkened_coat_color1.51853056
46MP0004947_skin_inflammation1.50905673
47MP0000678_abnormal_parathyroid_gland1.48246209
48* MP0005076_abnormal_cell_differentiation1.47677873
49MP0003303_peritoneal_inflammation1.46710707
50MP0010030_abnormal_orbit_morphology1.44693626
51MP0009278_abnormal_bone_marrow1.44445760
52MP0002089_abnormal_postnatal_growth/wei1.42122969
53MP0001293_anophthalmia1.41402716
54MP0004858_abnormal_nervous_system1.40975514
55MP0003119_abnormal_digestive_system1.38712740
56MP0002210_abnormal_sex_determination1.37976267
57MP0010234_abnormal_vibrissa_follicle1.36159503
58MP0003300_gastrointestinal_ulcer1.36127990
59MP0000313_abnormal_cell_death1.35977389
60MP0005257_abnormal_intraocular_pressure1.35527596
61MP0004808_abnormal_hematopoietic_stem1.34413267
62MP0005666_abnormal_adipose_tissue1.32996908
63MP0000569_abnormal_digit_pigmentation1.29900132
64MP0002653_abnormal_ependyma_morphology1.29454716
65MP0005375_adipose_tissue_phenotype1.28006579
66MP0002019_abnormal_tumor_incidence1.27252100
67MP0003191_abnormal_cellular_cholesterol1.27134162
68MP0001661_extended_life_span1.26939502
69MP0000490_abnormal_crypts_of1.26824963
70MP0000537_abnormal_urethra_morphology1.25558646
71MP0003567_abnormal_fetal_cardiomyocyte1.23560867
72MP0001145_abnormal_male_reproductive1.23123848
73MP0005501_abnormal_skin_physiology1.22849737
74MP0001873_stomach_inflammation1.22288905
75MP0001929_abnormal_gametogenesis1.21359747
76MP0002796_impaired_skin_barrier1.18120213
77MP0004133_heterotaxia1.17671898
78MP0005083_abnormal_biliary_tract1.15214711
79MP0005397_hematopoietic_system_phenotyp1.12862690
80MP0001545_abnormal_hematopoietic_system1.12862690
81MP0003718_maternal_effect1.11696931
82MP0002060_abnormal_skin_morphology1.11603479
83MP0009053_abnormal_anal_canal1.09921783
84MP0000703_abnormal_thymus_morphology1.03368492
85MP0003806_abnormal_nucleotide_metabolis1.02668081
86MP0003937_abnormal_limbs/digits/tail_de1.01148870
87MP0000653_abnormal_sex_gland1.00656898
88MP0002970_abnormal_white_adipose0.99810672
89MP0003315_abnormal_perineum_morphology0.99424731
90MP0005464_abnormal_platelet_physiology0.96654893
91MP0004264_abnormal_extraembryonic_tissu0.95065625
92MP0002092_abnormal_eye_morphology0.93363638
93MP0001849_ear_inflammation0.92679104
94MP0003656_abnormal_erythrocyte_physiolo0.90994636
95MP0003283_abnormal_digestive_organ0.90853666
96MP0009931_abnormal_skin_appearance0.90700263
97MP0009672_abnormal_birth_weight0.90211374
98MP0002111_abnormal_tail_morphology0.89723078
99MP0001915_intracranial_hemorrhage0.89535287
100MP0009703_decreased_birth_body0.88949912
101MP0000747_muscle_weakness0.88095025
102MP0003935_abnormal_craniofacial_develop0.86378044
103MP0003566_abnormal_cell_adhesion0.85767940
104MP0000428_abnormal_craniofacial_morphol0.85019649
105MP0004272_abnormal_basement_membrane0.84241501
106MP0005023_abnormal_wound_healing0.83650063
107MP0002998_abnormal_bone_remodeling0.82677752
108MP0003115_abnormal_respiratory_system0.82162402
109MP0009333_abnormal_splenocyte_physiolog0.81578424
110MP0000432_abnormal_head_morphology0.81066884
111* MP0005384_cellular_phenotype0.80707417
112MP0004233_abnormal_muscle_weight0.80539880
113* MP0005621_abnormal_cell_physiology0.80361737
114MP0001216_abnormal_epidermal_layer0.79816798
115MP0005360_urolithiasis0.79732220
116MP0001853_heart_inflammation0.78615495
117MP0010630_abnormal_cardiac_muscle0.78533641
118MP0001119_abnormal_female_reproductive0.78157593
119MP0003763_abnormal_thymus_physiology0.77655232
120MP0002697_abnormal_eye_size0.77168226
121MP0003698_abnormal_male_reproductive0.76916593
122MP0000767_abnormal_smooth_muscle0.76881213
123MP0002398_abnormal_bone_marrow0.75398843
124MP0001286_abnormal_eye_development0.75004229
125MP0002925_abnormal_cardiovascular_devel0.74920978
126MP0008770_decreased_survivor_rate0.74892215
127* MP0003861_abnormal_nervous_system0.74704243
128MP0003279_aneurysm0.74338828
129MP0003329_amyloid_beta_deposits0.74319474
130MP0002429_abnormal_blood_cell0.73921140
131MP0002722_abnormal_immune_system0.73422206
132MP0006292_abnormal_olfactory_placode0.73233448
133MP0000609_abnormal_liver_physiology0.73140405
134MP0003787_abnormal_imprinting0.71470047
135MP0002419_abnormal_innate_immunity0.69647330
136MP0000689_abnormal_spleen_morphology0.69460571
137MP0001243_abnormal_dermal_layer0.68974284
138MP0008995_early_reproductive_senescence0.67823740
139MP0002160_abnormal_reproductive_system0.67460777
140MP0002249_abnormal_larynx_morphology0.67279805
141MP0009384_cardiac_valve_regurgitation0.67017126
142MP0005389_reproductive_system_phenotype0.66883997
143MP0002161_abnormal_fertility/fecundity0.66024611
144MP0000358_abnormal_cell_content/0.65943965
145MP0000371_diluted_coat_color0.65206197
146MP0002114_abnormal_axial_skeleton0.60882405
147MP0003755_abnormal_palate_morphology0.60766069
148MP0002075_abnormal_coat/hair_pigmentati0.59856040
149MP0003950_abnormal_plasma_membrane0.59569400
150* MP0000733_abnormal_muscle_development0.59292947
151MP0003699_abnormal_female_reproductive0.58948851
152* MP0000266_abnormal_heart_morphology0.55415531

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.15225597
2Chromsome breakage (HP:0040012)4.04851264
3Ependymoma (HP:0002888)4.04427720
4Birth length less than 3rd percentile (HP:0003561)3.63732267
5Selective tooth agenesis (HP:0001592)3.50965894
6Impulsivity (HP:0100710)3.46669509
7Ulnar bowing (HP:0003031)3.25493881
8Medulloblastoma (HP:0002885)3.21880751
9Broad face (HP:0000283)3.18209989
10Abnormality of the astrocytes (HP:0100707)3.13065157
11Astrocytoma (HP:0009592)3.13065157
12Patellar aplasia (HP:0006443)3.11670473
13Breast hypoplasia (HP:0003187)3.10583123
14Abnormality of chromosome stability (HP:0003220)3.10073552
15Abnormality of the labia minora (HP:0012880)3.05943820
16Colon cancer (HP:0003003)3.05531640
17Meckel diverticulum (HP:0002245)3.04064943
18Absent radius (HP:0003974)3.03397176
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.02834722
20Deep venous thrombosis (HP:0002625)2.99826134
21Abnormality of the ileum (HP:0001549)2.98565948
22Ectopic kidney (HP:0000086)2.92696298
23Reticulocytopenia (HP:0001896)2.91733915
24Aplasia/Hypoplasia of the patella (HP:0006498)2.88814517
25Hemorrhage of the eye (HP:0011885)2.88575772
26Increased nuchal translucency (HP:0010880)2.85405816
27Protrusio acetabuli (HP:0003179)2.82775567
28Aplasia involving forearm bones (HP:0009822)2.82665693
29Absent forearm bone (HP:0003953)2.82665693
30Cerebral aneurysm (HP:0004944)2.78466852
31Glioma (HP:0009733)2.78259131
32Abnormal number of incisors (HP:0011064)2.72530615
33Abnormality of the preputium (HP:0100587)2.71441513
34Absent thumb (HP:0009777)2.70935238
35Small intestinal stenosis (HP:0012848)2.69937596
36Duodenal stenosis (HP:0100867)2.69937596
37Distal lower limb amyotrophy (HP:0008944)2.68173353
38Duplicated collecting system (HP:0000081)2.67607547
39Rhabdomyosarcoma (HP:0002859)2.62454828
40Volvulus (HP:0002580)2.59119938
41Basal cell carcinoma (HP:0002671)2.57049934
42Vertebral compression fractures (HP:0002953)2.54443880
43Carpal bone hypoplasia (HP:0001498)2.53794546
44Myelodysplasia (HP:0002863)2.51126892
45Upper limb amyotrophy (HP:0009129)2.50692715
46Distal upper limb amyotrophy (HP:0007149)2.50692715
47Increased connective tissue (HP:0009025)2.50405804
48Thin bony cortex (HP:0002753)2.49004261
49Cervical subluxation (HP:0003308)2.46982745
50Flat acetabular roof (HP:0003180)2.45921901
51Proximal placement of thumb (HP:0009623)2.43658789
52Premature rupture of membranes (HP:0001788)2.42722774
53Deviation of the thumb (HP:0009603)2.41810885
54Aplasia/hypoplasia of the humerus (HP:0006507)2.41311545
55Sloping forehead (HP:0000340)2.39638735
56Supernumerary spleens (HP:0009799)2.39275163
57Cafe-au-lait spot (HP:0000957)2.38885380
58J-shaped sella turcica (HP:0002680)2.38190147
59Biconcave vertebral bodies (HP:0004586)2.36906219
60Achilles tendon contracture (HP:0001771)2.35956740
61Abnormality of the carotid arteries (HP:0005344)2.35357106
62Neoplasm of the oral cavity (HP:0100649)2.34749949
63Degeneration of anterior horn cells (HP:0002398)2.32290847
64Abnormality of the anterior horn cell (HP:0006802)2.32290847
65Short humerus (HP:0005792)2.31642624
66Short 4th metacarpal (HP:0010044)2.30468409
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.30468409
68Disproportionate tall stature (HP:0001519)2.28981063
69Abnormality of the renal collecting system (HP:0004742)2.27924853
70Neoplasm of striated muscle (HP:0009728)2.27687643
71Prominent nose (HP:0000448)2.27631397
72Insomnia (HP:0100785)2.25431585
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.22784721
74Abnormality of the duodenum (HP:0002246)2.22600126
75High pitched voice (HP:0001620)2.20606115
76Abnormality of the Achilles tendon (HP:0005109)2.18582172
77Agnosia (HP:0010524)2.17387157
78Abnormality of the thoracic spine (HP:0100711)2.15612557
79Missing ribs (HP:0000921)2.15305274
8011 pairs of ribs (HP:0000878)2.14593459
81Short thumb (HP:0009778)2.09958381
82Myocardial infarction (HP:0001658)2.08336712
83Abnormality of the distal phalanx of the thumb (HP:0009617)2.08017638
84Squamous cell carcinoma (HP:0002860)2.06935127
85Nephroblastoma (Wilms tumor) (HP:0002667)2.05696319
86Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05052787
87Dysostosis multiplex (HP:0000943)2.03921518
88Spinal muscular atrophy (HP:0007269)2.03275588
89Asymmetry of the thorax (HP:0001555)2.01493649
90Reticulocytosis (HP:0001923)2.01240950
91Progressive external ophthalmoplegia (HP:0000590)2.00891705
92Atresia of the external auditory canal (HP:0000413)2.00081358
93Progressive muscle weakness (HP:0003323)2.00021332
94Abnormality of the fingertips (HP:0001211)1.99817738
95Abnormality of pyrimidine metabolism (HP:0004353)1.98717163
96Long palpebral fissure (HP:0000637)1.97998411
97Obstructive sleep apnea (HP:0002870)1.96458818
98Facial hemangioma (HP:0000329)1.96285984
99Abnormality of the lower motor neuron (HP:0002366)1.95895844
100Abnormal ossification of hand bones (HP:0005921)1.94947913
101Anal stenosis (HP:0002025)1.94268945
102Heterotopia (HP:0002282)1.93895158
103Cholecystitis (HP:0001082)1.91226073
104Abnormal gallbladder physiology (HP:0012438)1.91226073
105Ragged-red muscle fibers (HP:0003200)1.90860126
106Aplasia/Hypoplasia of the sternum (HP:0006714)1.90029132
107Oral leukoplakia (HP:0002745)1.89197481
108Horseshoe kidney (HP:0000085)1.88711391
109Abnormality of abdominal situs (HP:0011620)1.88483097
110Abdominal situs inversus (HP:0003363)1.88483097
111Rib fusion (HP:0000902)1.88459085
112Renal duplication (HP:0000075)1.88355105
113Dislocated radial head (HP:0003083)1.87227518
114Ankyloglossia (HP:0010296)1.86955323
115Abnormality of DNA repair (HP:0003254)1.86828590
116Mucopolysacchariduria (HP:0008155)1.86599164
117Urinary glycosaminoglycan excretion (HP:0003541)1.86599164
118Embryonal renal neoplasm (HP:0011794)1.85914849
119Increased cerebral lipofuscin (HP:0011813)1.85770283
120* Tracheoesophageal fistula (HP:0002575)1.84816357
121Fragile skin (HP:0001030)1.83882983
122Spinal cord lesions (HP:0100561)1.83759040
123Syringomyelia (HP:0003396)1.83759040
124Short nail (HP:0001799)1.83501758
125Abnormal lung lobation (HP:0002101)1.83497407
126Gastrointestinal carcinoma (HP:0002672)1.83081870
127Malignant gastrointestinal tract tumors (HP:0006749)1.83081870
128* Neoplasm of the pancreas (HP:0002894)1.83033063
129* Bone marrow hypocellularity (HP:0005528)1.82061550
130Centrally nucleated skeletal muscle fibers (HP:0003687)1.81654880
131Stridor (HP:0010307)1.81632673
132Pointed chin (HP:0000307)1.80993967
133Abnormality of carpal bone ossification (HP:0006257)1.80590751
134Abnormality of oral frenula (HP:0000190)1.79533236
135Cellulitis (HP:0100658)1.79507950
136Biliary tract neoplasm (HP:0100574)1.79162982
137Hand muscle atrophy (HP:0009130)1.78584856
138Premature skin wrinkling (HP:0100678)1.78126804
139Abnormality of polysaccharide metabolism (HP:0011012)1.78026937
140Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78026937
141Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78026937
142Hyperacusis (HP:0010780)1.77932207
143Dysmetric saccades (HP:0000641)1.77642506
144Shallow orbits (HP:0000586)1.75978811
145Absent epiphyses (HP:0010577)1.75805466
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75805466
147Abnormality of the calcaneus (HP:0008364)1.75611173
148Loss of speech (HP:0002371)1.75080722
149Skin tags (HP:0010609)1.74720771
150Cupped ribs (HP:0000887)1.74379913
151Ureteral duplication (HP:0000073)1.73693701
152Lower limb amyotrophy (HP:0007210)1.73674641
153Aneurysm (HP:0002617)1.73149190
154Blue sclerae (HP:0000592)1.72590215
155Abnormality of chromosome segregation (HP:0002916)1.72528651
156Colitis (HP:0002583)1.72271467
157Sandal gap (HP:0001852)1.72151539
158Triphalangeal thumb (HP:0001199)1.72056336
159Trismus (HP:0000211)1.70802323
160Abnormality of the radial head (HP:0003995)1.68836180
161Long eyelashes (HP:0000527)1.68705957
162Nonimmune hydrops fetalis (HP:0001790)1.68429923
163Distal lower limb muscle weakness (HP:0009053)1.67767321
164Mitral regurgitation (HP:0001653)1.67387620
165Premature ovarian failure (HP:0008209)1.66520676
166Abnormality of cells of the erythroid lineage (HP:0012130)1.66341666
167Difficulty climbing stairs (HP:0003551)1.66208662
168Clubbing of toes (HP:0100760)1.65958318
169Orthostatic hypotension (HP:0001278)1.65644214
170Increased neuronal autofluorescent lipopigment (HP:0002074)1.65074898
171Metaphyseal cupping (HP:0003021)1.64893422
172Ovarian neoplasm (HP:0100615)1.64749365
173Slow saccadic eye movements (HP:0000514)1.63934136
174Nuclear cataract (HP:0100018)1.62784536
175Wormian bones (HP:0002645)1.62636229
176Advanced eruption of teeth (HP:0006288)1.61466341
177Broad distal phalanx of finger (HP:0009836)1.61405792
178Thoracic kyphosis (HP:0002942)1.61177480
179Sparse lateral eyebrow (HP:0005338)1.58801396
180Poikiloderma (HP:0001029)1.58543588
181Patellar dislocation (HP:0002999)1.57126103
182Increased serum ferritin (HP:0003281)1.56645819
183Urethral obstruction (HP:0000796)1.55642819
184Deformed sella turcica (HP:0002681)1.54749698
185Elbow flexion contracture (HP:0002987)1.54738134
186Abnormality of the acetabulum (HP:0003170)1.54569109
187Upper motor neuron abnormality (HP:0002127)1.54087591
188Self-mutilation (HP:0000742)1.52878180
189Osteolytic defects of the hand bones (HP:0009699)1.50681730
190Osteolytic defects of the phalanges of the hand (HP:0009771)1.50681730
191Hypertriglyceridemia (HP:0002155)1.49631727
192Mitral valve prolapse (HP:0001634)1.49534922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.61165471
2BUB14.04837608
3CDK123.95496116
4WEE13.85571526
5SMG13.58794367
6NEK23.46327930
7IRAK33.02421135
8TTK2.81521064
9PRPF4B2.78860826
10SIK12.76348469
11ERN12.54067123
12NEK12.49871665
13SRPK12.35288724
14FGFR42.33511508
15EEF2K2.20842333
16PLK12.08183242
17ATR2.06019841
18MAP3K102.03642692
19MST1R1.85712283
20CHEK21.84470090
21PASK1.84077856
22CDK71.83092704
23MAP2K31.81332879
24AURKB1.76851038
25RIPK11.72098373
26BRSK21.71267827
27TLK11.66961667
28CHEK11.66771479
29CDK41.66602752
30BRD41.65817933
31ACVR1B1.60998073
32PLK41.60151697
33RPS6KB21.59060332
34TSSK61.54959243
35PLK31.51589366
36EPHA21.44924996
37STK101.38955828
38BRSK11.37800782
39MAP3K81.30901161
40MAP3K131.26882154
41TAOK21.26695539
42ZAK1.24855567
43TESK21.20674271
44ATM1.20528517
45PKN21.18386107
46MKNK11.18090874
47DYRK31.17631484
48STK41.14901094
49CDK21.12125343
50EIF2AK11.12103337
51ALK1.09093106
52AURKA1.08842012
53AKT31.06340747
54VRK11.06200231
55CDK61.06162406
56MKNK21.05473647
57SIK21.04995686
58PIM11.02415373
59PTK61.02197858
60CDC42BPA1.01996152
61ICK1.01191743
62MTOR1.01047400
63MAPK111.00189863
64MELK1.00162210
65TAOK10.98554915
66STK30.94309454
67PAK40.94175822
68MAP3K30.93724882
69RPS6KA40.91269417
70RIPK40.90126405
71PTK20.88242414
72PDPK10.86686188
73CDK10.86661387
74KSR20.85483626
75TTN0.85401778
76MARK20.84584410
77MAP3K110.83615288
78CCNB10.83174874
79TRIB30.82573686
80PRKD20.82462604
81SCYL20.80296745
82MAP3K140.79994597
83MAP3K10.79840726
84ZAP700.76064445
85MET0.75249379
86TYK20.74437976
87MAP4K10.70169380
88IRAK40.70157308
89PNCK0.70108787
90TGFBR10.69669881
91TBK10.68939362
92EPHB10.67489275
93GRK60.66701926
94IRAK20.64038929
95LATS10.63455387
96RPS6KA20.63239183
97NME20.62939684
98PDK40.61599892
99PDK30.61599892
100FGFR30.56113100
101PAK10.55287930
102LMTK20.54768291
103SIK30.54310103
104CSNK1D0.53932433
105CSNK2A20.53797441
106PRKDC0.52700534
107MAP3K60.52662388
108YES10.52495627
109FGFR10.50815797
110AKT20.50467478
111RET0.47420861
112CDK80.47324254
113ARAF0.47005851
114MAPK140.46056338
115PIM20.45743955
116MAPKAPK30.44880736
117PDK10.44812796
118HIPK20.44296740
119DDR20.44028889
120PRKCI0.43322471
121PRKD30.43102615
122CAMK1G0.42429991
123CSNK2A10.42255037
124BLK0.41194711
125PAK20.40673957
126CSNK1E0.40531034
127MAP3K70.39911633
128MAP2K20.39180845
129TYRO30.38839329
130MATK0.38731539
131EIF2AK30.38091906
132JAK30.38081740
133AKT10.37946404
134PDGFRB0.37627501
135STK380.37584936
136BRAF0.37328376
137GSK3B0.37179521
138MAPKAPK20.37041795
139RPS6KA60.35787628
140FLT30.35708484
141LRRK20.33909146
142RPS6KA10.33319417
143CLK10.33174036
144STK38L0.30713454
145KSR10.30492847
146MAPK10.30098097
147PDGFRA0.29768831
148RPS6KA50.28694814
149MARK30.28131972
150DYRK1B0.27903166
151TESK10.27220064
152RPS6KC10.27016537
153RPS6KL10.27016537
154BMX0.26554495
155CAMK1D0.25778282
156LATS20.25489196
157CDK90.25343054

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.14907822
2Mismatch repair_Homo sapiens_hsa034304.52141359
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.57457524
4Other glycan degradation_Homo sapiens_hsa005113.52406566
5RNA transport_Homo sapiens_hsa030133.28479582
6Base excision repair_Homo sapiens_hsa034103.27979271
7Cell cycle_Homo sapiens_hsa041103.19823961
8Spliceosome_Homo sapiens_hsa030403.13555556
9One carbon pool by folate_Homo sapiens_hsa006703.11017793
10Homologous recombination_Homo sapiens_hsa034403.06074825
11Fanconi anemia pathway_Homo sapiens_hsa034602.86971687
12Nucleotide excision repair_Homo sapiens_hsa034202.72360010
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.57525495
14mRNA surveillance pathway_Homo sapiens_hsa030152.22076371
15RNA polymerase_Homo sapiens_hsa030202.10855353
16Non-homologous end-joining_Homo sapiens_hsa034502.09636354
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.97289793
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.94428754
19Pyrimidine metabolism_Homo sapiens_hsa002401.90887707
20p53 signaling pathway_Homo sapiens_hsa041151.82714302
21Systemic lupus erythematosus_Homo sapiens_hsa053221.71795382
22RNA degradation_Homo sapiens_hsa030181.68436583
23Ribosome_Homo sapiens_hsa030101.65013958
24Basal transcription factors_Homo sapiens_hsa030221.55527403
25VEGF signaling pathway_Homo sapiens_hsa043701.49352242
26Proteasome_Homo sapiens_hsa030501.49146665
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37456151
28Oocyte meiosis_Homo sapiens_hsa041141.31603313
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27118089
30Viral carcinogenesis_Homo sapiens_hsa052031.23534207
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18645378
32Prion diseases_Homo sapiens_hsa050201.13242277
33Galactose metabolism_Homo sapiens_hsa000521.11873947
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09762589
35Epstein-Barr virus infection_Homo sapiens_hsa051691.07702332
36Glioma_Homo sapiens_hsa052141.07393932
37Biosynthesis of amino acids_Homo sapiens_hsa012301.06498789
38MicroRNAs in cancer_Homo sapiens_hsa052061.05139040
39Lysosome_Homo sapiens_hsa041421.04069430
40Selenocompound metabolism_Homo sapiens_hsa004501.03878181
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.01952621
42HTLV-I infection_Homo sapiens_hsa051661.01046822
43Insulin signaling pathway_Homo sapiens_hsa049100.99349253
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98594240
45Renal cell carcinoma_Homo sapiens_hsa052110.96805851
46Lysine degradation_Homo sapiens_hsa003100.96761837
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95423587
48Hepatitis C_Homo sapiens_hsa051600.95199738
49Osteoclast differentiation_Homo sapiens_hsa043800.94950326
50Purine metabolism_Homo sapiens_hsa002300.92171375
51Vitamin B6 metabolism_Homo sapiens_hsa007500.92062944
52Herpes simplex infection_Homo sapiens_hsa051680.91214802
53ErbB signaling pathway_Homo sapiens_hsa040120.90488905
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89285037
55Basal cell carcinoma_Homo sapiens_hsa052170.88965081
56Small cell lung cancer_Homo sapiens_hsa052220.87277130
57TNF signaling pathway_Homo sapiens_hsa046680.86299305
58Focal adhesion_Homo sapiens_hsa045100.85891904
59Inositol phosphate metabolism_Homo sapiens_hsa005620.84614003
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84325589
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84316508
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.81057907
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.80215137
64mTOR signaling pathway_Homo sapiens_hsa041500.80030943
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79865649
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79789248
67Insulin resistance_Homo sapiens_hsa049310.78671106
68Hippo signaling pathway_Homo sapiens_hsa043900.76352139
69Notch signaling pathway_Homo sapiens_hsa043300.75999614
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74127451
71Pentose phosphate pathway_Homo sapiens_hsa000300.73873852
72Toxoplasmosis_Homo sapiens_hsa051450.70448060
73Colorectal cancer_Homo sapiens_hsa052100.70132209
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.70101777
75Antigen processing and presentation_Homo sapiens_hsa046120.69980319
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.69738546
77GnRH signaling pathway_Homo sapiens_hsa049120.69488440
78Choline metabolism in cancer_Homo sapiens_hsa052310.69343170
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.67143750
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.66431996
81Alcoholism_Homo sapiens_hsa050340.66374309
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64437614
83Prolactin signaling pathway_Homo sapiens_hsa049170.63332583
84Chronic myeloid leukemia_Homo sapiens_hsa052200.61620444
85T cell receptor signaling pathway_Homo sapiens_hsa046600.60784090
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60570023
87Hedgehog signaling pathway_Homo sapiens_hsa043400.60233261
88Estrogen signaling pathway_Homo sapiens_hsa049150.59889253
89Amoebiasis_Homo sapiens_hsa051460.58792619
90Endocytosis_Homo sapiens_hsa041440.58488157
912-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57784545
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57783228
93Arginine biosynthesis_Homo sapiens_hsa002200.55194469
94TGF-beta signaling pathway_Homo sapiens_hsa043500.55096083
95Leishmaniasis_Homo sapiens_hsa051400.54560767
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.54377701
97Thyroid cancer_Homo sapiens_hsa052160.54083315
98Primary immunodeficiency_Homo sapiens_hsa053400.53866039
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.53548958
100ECM-receptor interaction_Homo sapiens_hsa045120.50641246
101Fructose and mannose metabolism_Homo sapiens_hsa000510.47344781
102Adherens junction_Homo sapiens_hsa045200.47161290
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45910440
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45370159
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43411869
106Bladder cancer_Homo sapiens_hsa052190.43313135
107Apoptosis_Homo sapiens_hsa042100.42431193
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39255227
109Folate biosynthesis_Homo sapiens_hsa007900.38136384
110Prostate cancer_Homo sapiens_hsa052150.38066169
111Hepatitis B_Homo sapiens_hsa051610.37912767
112Carbon metabolism_Homo sapiens_hsa012000.37882252
113Pathways in cancer_Homo sapiens_hsa052000.37340293
114Non-small cell lung cancer_Homo sapiens_hsa052230.35788941
115Viral myocarditis_Homo sapiens_hsa054160.34109849
116HIF-1 signaling pathway_Homo sapiens_hsa040660.33375334
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.33159860
118Wnt signaling pathway_Homo sapiens_hsa043100.32015137
119Proteoglycans in cancer_Homo sapiens_hsa052050.31478562
120FoxO signaling pathway_Homo sapiens_hsa040680.29308233
121Endometrial cancer_Homo sapiens_hsa052130.28959034
122Measles_Homo sapiens_hsa051620.27896153
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27668090
124Sulfur relay system_Homo sapiens_hsa041220.27566139
125Acute myeloid leukemia_Homo sapiens_hsa052210.26275150
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26068121
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25946373
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24712245
129N-Glycan biosynthesis_Homo sapiens_hsa005100.24375082
130AMPK signaling pathway_Homo sapiens_hsa041520.23099175
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22905748
132Pancreatic cancer_Homo sapiens_hsa052120.22476072
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22236064
134Legionellosis_Homo sapiens_hsa051340.21360972
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20855336
136Tight junction_Homo sapiens_hsa045300.19926349
137B cell receptor signaling pathway_Homo sapiens_hsa046620.19665369
138Shigellosis_Homo sapiens_hsa051310.18966153
139Influenza A_Homo sapiens_hsa051640.18043229
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18012786
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16751656
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16005102
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14032817
144Melanoma_Homo sapiens_hsa052180.13326719

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