RTBDN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was first identified in a study of human eye tissues. The protein encoded by this gene is preferentially expressed in the retina and may play a role in binding retinoids and other carotenoids as it shares homology with riboflavin binding proteins. Alternative splicing results in multiple transcript variants and protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GMP metabolic process (GO:0046037)8.50699808
2visual perception (GO:0007601)8.47978807
3sensory perception of light stimulus (GO:0050953)8.38609865
4retinal rod cell development (GO:0046548)7.74636371
5cellular response to light stimulus (GO:0071482)7.32991383
6detection of external stimulus (GO:0009581)7.02817195
7detection of abiotic stimulus (GO:0009582)6.90622906
8detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)6.87681609
9regulation of cGMP metabolic process (GO:0030823)6.83832140
10positive regulation of cGMP biosynthetic process (GO:0030828)6.64846812
11eye photoreceptor cell differentiation (GO:0001754)6.57083876
12photoreceptor cell differentiation (GO:0046530)6.57083876
13regulation of cGMP biosynthetic process (GO:0030826)6.23202878
14retina development in camera-type eye (GO:0060041)6.00911234
15positive regulation of cGMP metabolic process (GO:0030825)5.89664649
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.63801636
17receptor guanylyl cyclase signaling pathway (GO:0007168)5.19517338
18positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.06509724
19behavioral response to nicotine (GO:0035095)5.01673533
20nonmotile primary cilium assembly (GO:0035058)4.97627682
21cellular response to radiation (GO:0071478)4.81447319
22cell morphogenesis involved in neuron differentiation (GO:0048667)4.70430242
23regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.42512105
24regulation of penile erection (GO:0060405)4.10805144
25regulation of voltage-gated calcium channel activity (GO:1901385)4.09426172
26adaptation of signaling pathway (GO:0023058)4.07475440
27short-term memory (GO:0007614)4.05735342
28behavioral response to ethanol (GO:0048149)4.02801142
29sensory perception (GO:0007600)4.01414650
30detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.00679166
31regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.90679511
32regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.90679511
33positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.88373693
34fucose catabolic process (GO:0019317)3.87408374
35L-fucose metabolic process (GO:0042354)3.87408374
36L-fucose catabolic process (GO:0042355)3.87408374
37estrogen biosynthetic process (GO:0006703)3.86638374
38response to light stimulus (GO:0009416)3.84124826
39chemosensory behavior (GO:0007635)3.73750968
40positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.69251597
41positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.66172082
42protein-cofactor linkage (GO:0018065)3.64740225
43detection of chemical stimulus involved in sensory perception (GO:0050907)3.64732779
44response to histamine (GO:0034776)3.63072852
45respiratory chain complex IV assembly (GO:0008535)3.56737899
46protein K11-linked deubiquitination (GO:0035871)3.49932939
47piRNA metabolic process (GO:0034587)3.47005283
48neuron development (GO:0048666)3.45313187
49positive regulation of ERBB signaling pathway (GO:1901186)3.43358924
50retina layer formation (GO:0010842)3.41095371
51positive regulation of neurotransmitter transport (GO:0051590)3.38117935
52indolalkylamine metabolic process (GO:0006586)3.37639700
53positive regulation of sodium ion transmembrane transport (GO:1902307)3.37137202
54protein prenylation (GO:0018342)3.31189863
55prenylation (GO:0097354)3.31189863
56detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.27521995
57kynurenine metabolic process (GO:0070189)3.26217046
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.25994595
59cellular ketone body metabolic process (GO:0046950)3.21968778
60protein complex biogenesis (GO:0070271)3.21456356
61indolalkylamine catabolic process (GO:0046218)3.21099138
62tryptophan catabolic process (GO:0006569)3.21099138
63indole-containing compound catabolic process (GO:0042436)3.21099138
64establishment of protein localization to mitochondrial membrane (GO:0090151)3.18652225
65retina homeostasis (GO:0001895)3.18102056
66regulation of glucokinase activity (GO:0033131)3.16619883
67regulation of hexokinase activity (GO:1903299)3.16619883
68cellular response to ATP (GO:0071318)3.14999465
69mitochondrial respiratory chain complex I assembly (GO:0032981)3.14067800
70NADH dehydrogenase complex assembly (GO:0010257)3.14067800
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14067800
72primary amino compound metabolic process (GO:1901160)3.12722451
73mitochondrial respiratory chain complex assembly (GO:0033108)3.11028058
74membrane hyperpolarization (GO:0060081)3.08363193
75meiotic chromosome segregation (GO:0045132)3.02562251
76water-soluble vitamin biosynthetic process (GO:0042364)3.02438013
77platelet dense granule organization (GO:0060155)2.99805767
78cytochrome complex assembly (GO:0017004)2.99317864
79retinoid metabolic process (GO:0001523)2.97885218
80regulation of action potential (GO:0098900)2.97024202
81ketone body metabolic process (GO:1902224)2.96949147
82serotonin metabolic process (GO:0042428)2.95200757
83indole-containing compound metabolic process (GO:0042430)2.93044949
84negative regulation of telomere maintenance (GO:0032205)2.91467318
85regulation of clathrin-mediated endocytosis (GO:2000369)2.88603685
86preassembly of GPI anchor in ER membrane (GO:0016254)2.85191344
87regulation of nuclear cell cycle DNA replication (GO:0033262)2.85164583
88reciprocal meiotic recombination (GO:0007131)2.84748650
89reciprocal DNA recombination (GO:0035825)2.84748650
90intracellular protein transmembrane import (GO:0044743)2.83782427
91synaptic transmission, dopaminergic (GO:0001963)2.82941709
92auditory receptor cell stereocilium organization (GO:0060088)2.82192895
93DNA methylation involved in gamete generation (GO:0043046)2.82167541
94tryptophan metabolic process (GO:0006568)2.81207588
95behavioral response to cocaine (GO:0048148)2.79173872
96CDP-diacylglycerol biosynthetic process (GO:0016024)2.79057664
97regulation of meiosis I (GO:0060631)2.78917096
98diterpenoid metabolic process (GO:0016101)2.74665947
99male meiosis (GO:0007140)2.74108197
100rRNA catabolic process (GO:0016075)2.72649808
101phosphatidylinositol acyl-chain remodeling (GO:0036149)2.72376216
102regulation of neurotransmitter uptake (GO:0051580)2.71820238
103positive regulation of cyclase activity (GO:0031281)2.70606847
104response to radiation (GO:0009314)2.69564665
105icosanoid secretion (GO:0032309)2.69465091
106arachidonic acid secretion (GO:0050482)2.69465091
107protein localization to synapse (GO:0035418)2.69060964
108somite rostral/caudal axis specification (GO:0032525)2.68402637
109negative regulation of transcription regulatory region DNA binding (GO:2000678)2.67988106
110gamma-aminobutyric acid transport (GO:0015812)2.67981600
111protein heterotetramerization (GO:0051290)2.66909315
112protein import into peroxisome matrix (GO:0016558)2.66621549
113cornea development in camera-type eye (GO:0061303)2.65736819
114mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.64889535
115glycerophospholipid catabolic process (GO:0046475)2.63603185
116regulation of short-term neuronal synaptic plasticity (GO:0048172)2.62569514
117positive regulation of mitochondrial fission (GO:0090141)2.61153807
118dopamine transport (GO:0015872)2.61057401
119dopamine receptor signaling pathway (GO:0007212)2.59197725
120inner ear receptor stereocilium organization (GO:0060122)2.57486739
121C-terminal protein lipidation (GO:0006501)2.57407438
122mannosylation (GO:0097502)2.57255243
123phospholipid translocation (GO:0045332)2.55973562
124lipid translocation (GO:0034204)2.55973562
125ubiquinone biosynthetic process (GO:0006744)2.55889678
126regulation of cilium movement (GO:0003352)2.55472157
127sex differentiation (GO:0007548)2.55236565
128righting reflex (GO:0060013)2.54454689
129C-terminal protein amino acid modification (GO:0018410)2.53520376
130CDP-diacylglycerol metabolic process (GO:0046341)2.52631191
131DNA deamination (GO:0045006)2.52246949
132negative regulation of cation channel activity (GO:2001258)2.51853368
133terpenoid metabolic process (GO:0006721)2.50083981
134neuronal action potential (GO:0019228)2.49979429
135response to pheromone (GO:0019236)2.49373929
136regulation of catecholamine metabolic process (GO:0042069)2.49021374
137regulation of dopamine metabolic process (GO:0042053)2.49021374
138positive regulation of lyase activity (GO:0051349)2.48771377
139negative regulation of calcium ion transmembrane transport (GO:1903170)2.47860250
140negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.47860250
141negative regulation of receptor-mediated endocytosis (GO:0048261)2.47796916
142startle response (GO:0001964)2.47206384
143positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.46933225
144peptidyl-histidine modification (GO:0018202)2.46741350
145negative regulation of synaptic transmission, GABAergic (GO:0032229)2.46016939
146cellular response to abiotic stimulus (GO:0071214)2.45940637
147spinal cord motor neuron differentiation (GO:0021522)2.45715380
148base-excision repair, AP site formation (GO:0006285)2.45477073
149positive regulation of meiosis (GO:0045836)2.45397840
150energy coupled proton transport, down electrochemical gradient (GO:0015985)2.44731970
151ATP synthesis coupled proton transport (GO:0015986)2.44731970
152synapsis (GO:0007129)2.43895045
153mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.43040376
154phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.41305214
155male meiosis I (GO:0007141)2.41269407
156retinol metabolic process (GO:0042572)2.40750286
157reflex (GO:0060004)2.38171789
158pseudouridine synthesis (GO:0001522)2.38143396
159phosphatidylserine acyl-chain remodeling (GO:0036150)2.38108249
160ubiquinone metabolic process (GO:0006743)2.37908589
161intracellular protein transmembrane transport (GO:0065002)2.37816902
162positive regulation of prostaglandin secretion (GO:0032308)2.37754620
163G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.37141689
164L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.36839387
165tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.36628351
166RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.36628351
167transcription elongation from RNA polymerase III promoter (GO:0006385)2.36449820
168axoneme assembly (GO:0035082)2.33771131
169synaptic vesicle docking involved in exocytosis (GO:0016081)2.31135080
170peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.24251743
171regulation of rhodopsin mediated signaling pathway (GO:0022400)18.3828446
172rhodopsin mediated signaling pathway (GO:0016056)17.7747250
173retinal cone cell development (GO:0046549)17.7283790
174photoreceptor cell development (GO:0042461)11.7311904
175detection of light stimulus involved in visual perception (GO:0050908)11.5356542
176detection of light stimulus involved in sensory perception (GO:0050962)11.5356542
177eye photoreceptor cell development (GO:0042462)11.4642454
178photoreceptor cell maintenance (GO:0045494)11.4063293
179positive regulation of guanylate cyclase activity (GO:0031284)11.3788902
180protein-chromophore linkage (GO:0018298)10.6852533
181phototransduction (GO:0007602)10.6496626
182phototransduction, visible light (GO:0007603)10.5846691
183regulation of guanylate cyclase activity (GO:0031282)10.2674057
184detection of visible light (GO:0009584)10.1452456
185detection of light stimulus (GO:0009583)10.0559315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.08651160
2VDR_22108803_ChIP-Seq_LS180_Human4.11669608
3ZNF274_21170338_ChIP-Seq_K562_Hela3.92675659
4CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.64919523
5GBX2_23144817_ChIP-Seq_PC3_Human3.53845043
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.49456816
7EZH2_22144423_ChIP-Seq_EOC_Human2.95085075
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.72309776
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54061015
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.21697370
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.20310511
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.18477762
13AR_21572438_ChIP-Seq_LNCaP_Human2.10996325
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08230981
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08162102
16IGF1R_20145208_ChIP-Seq_DFB_Human2.07971880
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.05618715
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94907637
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92714586
20CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92100838
21EWS_26573619_Chip-Seq_HEK293_Human1.90567354
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90234036
23FUS_26573619_Chip-Seq_HEK293_Human1.87269391
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86245912
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.83296882
26* TP53_22573176_ChIP-Seq_HFKS_Human1.78159604
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77181988
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76304855
29SMAD3_21741376_ChIP-Seq_HESCs_Human1.72795628
30TAF15_26573619_Chip-Seq_HEK293_Human1.70483791
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.67615354
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64730567
33* DROSHA_22980978_ChIP-Seq_HELA_Human1.64290300
34* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62103248
35MYC_18940864_ChIP-ChIP_HL60_Human1.58482147
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.58015888
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.55619871
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54635092
39AR_19668381_ChIP-Seq_PC3_Human1.52690807
40SMAD4_21799915_ChIP-Seq_A2780_Human1.52650287
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51990482
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51019071
43P53_22127205_ChIP-Seq_FIBROBLAST_Human1.47149144
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46778106
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44610422
46TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.44252084
47* EZH2_27294783_Chip-Seq_ESCs_Mouse1.44198852
48P300_19829295_ChIP-Seq_ESCs_Human1.43442314
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43378013
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42408268
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41325718
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39920782
53* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39635315
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38617019
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38158075
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.37380401
57STAT3_23295773_ChIP-Seq_U87_Human1.36236936
58* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35899824
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.35427736
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35427736
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.34380138
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34265245
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34249640
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34243925
65JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34035980
66* REST_21632747_ChIP-Seq_MESCs_Mouse1.33763873
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33303650
68RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31802030
69EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31802030
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31694526
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.31020252
72BCAT_22108803_ChIP-Seq_LS180_Human1.29418415
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.29103824
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.28215890
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28133620
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28122700
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.27980798
78TBL1_22424771_ChIP-Seq_293T_Human1.27897621
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.27885703
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27263977
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.27002185
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.26522600
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25905630
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25593896
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25083789
86GATA3_21878914_ChIP-Seq_MCF-7_Human1.24305041
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23581393
88CBP_20019798_ChIP-Seq_JUKART_Human1.23581393
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22846217
90VDR_23849224_ChIP-Seq_CD4+_Human1.22360164
91AR_25329375_ChIP-Seq_VCAP_Human1.20942729
92MYC_19829295_ChIP-Seq_ESCs_Human1.20914045
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.19484257
94IRF1_19129219_ChIP-ChIP_H3396_Human1.19185333
95ERA_21632823_ChIP-Seq_H3396_Human1.19179804
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19131227
97JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16980226
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16060799
99LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14727150
100HOXB7_26014856_ChIP-Seq_BT474_Human1.14351687
101* NCOR_22424771_ChIP-Seq_293T_Human1.13947669
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13826595
103RARB_27405468_Chip-Seq_BRAIN_Mouse1.13231133
104RNF2_27304074_Chip-Seq_NSC_Mouse1.13090078
105SOX2_19829295_ChIP-Seq_ESCs_Human1.12886370
106NANOG_19829295_ChIP-Seq_ESCs_Human1.12886370
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11460536
108CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10332793
109TCF4_23295773_ChIP-Seq_U87_Human1.09636072
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07800827
111ER_23166858_ChIP-Seq_MCF-7_Human1.07212588
112AR_20517297_ChIP-Seq_VCAP_Human1.06973100
113SRF_21415370_ChIP-Seq_HL-1_Mouse1.06427017
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05277750
115TCF4_22108803_ChIP-Seq_LS180_Human1.04704516
116WDR5_24793694_ChIP-Seq_LNCAP_Human1.04601904
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04587304
118* KDM2B_26808549_Chip-Seq_K562_Human1.04455653
119YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04450107
120GATA2_21666600_ChIP-Seq_HMVEC_Human1.03457956
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02354109
122* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.02090040
123TAF2_19829295_ChIP-Seq_ESCs_Human1.01853146
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01269376
125GF1_26923725_Chip-Seq_HPCs_Mouse1.00548610
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99956610
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99709185
128CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99676322
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99662284
130RUNX2_22187159_ChIP-Seq_PCA_Human0.99289381
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99237821
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99237821
133E2F1_18555785_Chip-Seq_ESCs_Mouse0.98805643
134NANOG_20526341_ChIP-Seq_ESCs_Human0.96995359
135POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96702880
136EED_16625203_ChIP-ChIP_MESCs_Mouse0.96405101
137OCT1_27270436_Chip-Seq_PROSTATE_Human0.95888484
138ELK1_19687146_ChIP-ChIP_HELA_Human0.95620106
139CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95111854
140SMAD4_21741376_ChIP-Seq_EPCs_Human0.94526365
141OCT4_20526341_ChIP-Seq_ESCs_Human0.94189116
142GF1B_26923725_Chip-Seq_HPCs_Mouse0.94126618
143CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93787660
144AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93495377
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.93439924
146SMAD3_21741376_ChIP-Seq_EPCs_Human0.93253935
147ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92525483
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92336104
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92305463
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.91909245
151KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91881880
152UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91601519
153* ISL1_27105846_Chip-Seq_CPCs_Mouse0.90069436
154NFE2_27457419_Chip-Seq_LIVER_Mouse0.89666684
155PIAS1_25552417_ChIP-Seq_VCAP_Human0.89628086
156* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89484067
157BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88971340
158SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88841832
159CBP_21632823_ChIP-Seq_H3396_Human0.87798145
160FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87591619
161SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87363691
162* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87236069
163RUNX_20019798_ChIP-Seq_JUKART_Human0.87050017
164CBX2_27304074_Chip-Seq_ESCs_Mouse0.86171975
165KDM2B_26808549_Chip-Seq_REH_Human0.85557155
166TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84027072
167TAL1_26923725_Chip-Seq_HPCs_Mouse0.83805214
168SOX2_18555785_Chip-Seq_ESCs_Mouse0.83338187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005253_abnormal_eye_physiology6.98579614
2MP0006072_abnormal_retinal_apoptosis6.29552948
3MP0003950_abnormal_plasma_membrane4.10841485
4MP0005195_abnormal_posterior_eye3.87878416
5MP0005391_vision/eye_phenotype3.35875172
6MP0001324_abnormal_eye_pigmentation3.35711546
7MP0002090_abnormal_vision3.11566534
8MP0005423_abnormal_somatic_nervous2.97316226
9MP0001986_abnormal_taste_sensitivity2.82305359
10MP0003136_yellow_coat_color2.79710169
11MP0008877_abnormal_DNA_methylation2.70459792
12MP0002638_abnormal_pupillary_reflex2.70287009
13MP0002229_neurodegeneration2.55725552
14MP0008875_abnormal_xenobiotic_pharmacok2.48020192
15MP0003195_calcinosis2.35480189
16MP0003787_abnormal_imprinting2.01948431
17MP0003011_delayed_dark_adaptation10.5612234
18MP0005551_abnormal_eye_electrophysiolog10.1497805
19MP0001764_abnormal_homeostasis1.94508853
20MP0002752_abnormal_somatic_nervous1.94412011
21MP0002736_abnormal_nociception_after1.92994508
22MP0008872_abnormal_physiological_respon1.83574751
23MP0002837_dystrophic_cardiac_calcinosis1.71316350
24MP0004133_heterotaxia1.69864828
25MP0000372_irregular_coat_pigmentation1.69320967
26MP0002938_white_spotting1.57761913
27MP0005174_abnormal_tail_pigmentation1.53712574
28MP0002876_abnormal_thyroid_physiology1.52280085
29MP0006276_abnormal_autonomic_nervous1.51278862
30MP0005171_absent_coat_pigmentation1.45530972
31MP0005645_abnormal_hypothalamus_physiol1.45144622
32MP0002735_abnormal_chemical_nociception1.44724125
33MP0004019_abnormal_vitamin_homeostasis1.37659921
34MP0002882_abnormal_neuron_morphology1.37166385
35MP0002254_reproductive_system_inflammat1.36896526
36MP0003283_abnormal_digestive_organ1.35279196
37MP0001485_abnormal_pinna_reflex1.34279781
38MP0002909_abnormal_adrenal_gland1.30588973
39MP0001984_abnormal_olfaction1.26850015
40MP0003718_maternal_effect1.26728245
41MP0004147_increased_porphyrin_level1.26681458
42MP0002653_abnormal_ependyma_morphology1.26024583
43MP0004043_abnormal_pH_regulation1.25066624
44MP0002160_abnormal_reproductive_system1.23318782
45MP0004233_abnormal_muscle_weight1.21895336
46MP0002733_abnormal_thermal_nociception1.20292085
47MP0005332_abnormal_amino_acid1.15480611
48MP0000427_abnormal_hair_cycle1.14204740
49MP0003122_maternal_imprinting1.12726181
50MP0001529_abnormal_vocalization1.12056929
51MP0002163_abnormal_gland_morphology1.07055014
52MP0001502_abnormal_circadian_rhythm1.03533536
53MP0005197_abnormal_uvea_morphology1.03400839
54MP0002693_abnormal_pancreas_physiology1.02032684
55MP0002210_abnormal_sex_determination1.00747597
56MP0005389_reproductive_system_phenotype0.98725933
57MP0002127_abnormal_cardiovascular_syste0.93761224
58MP0001944_abnormal_pancreas_morphology0.92707967
59MP0003121_genomic_imprinting0.92003977
60MP0002332_abnormal_exercise_endurance0.91348341
61MP0005167_abnormal_blood-brain_barrier0.90932001
62MP0001486_abnormal_startle_reflex0.90400150
63MP0003698_abnormal_male_reproductive0.89745107
64MP0003119_abnormal_digestive_system0.89217957
65MP0002751_abnormal_autonomic_nervous0.88511737
66MP0001919_abnormal_reproductive_system0.87235415
67MP0005379_endocrine/exocrine_gland_phen0.87041852
68MP0004885_abnormal_endolymph0.86338556
69MP0005365_abnormal_bile_salt0.85977197
70MP0001756_abnormal_urination0.84479360
71MP0006292_abnormal_olfactory_placode0.83998245
72MP0005410_abnormal_fertilization0.83023348
73MP0005448_abnormal_energy_balance0.82381010
74MP0000383_abnormal_hair_follicle0.81143445
75MP0005499_abnormal_olfactory_system0.75616634
76MP0005394_taste/olfaction_phenotype0.75616634
77MP0004270_analgesia0.73083805
78MP0002272_abnormal_nervous_system0.71977165
79MP0008789_abnormal_olfactory_epithelium0.68004794
80MP0008004_abnormal_stomach_pH0.67950784
81MP0003634_abnormal_glial_cell0.65106065
82MP0002734_abnormal_mechanical_nocicepti0.63134054
83MP0001963_abnormal_hearing_physiology0.59541083
84MP0005187_abnormal_penis_morphology0.56944242
85MP0005646_abnormal_pituitary_gland0.55327898
86MP0001286_abnormal_eye_development0.52446012
87MP0002572_abnormal_emotion/affect_behav0.50909606
88MP0003045_fibrosis0.50093324
89MP0000465_gastrointestinal_hemorrhage0.49901171
90MP0003646_muscle_fatigue0.49420575
91MP0004859_abnormal_synaptic_plasticity0.45901242
92MP0001968_abnormal_touch/_nociception0.45547659
93MP0002064_seizures0.45376207
94MP0001905_abnormal_dopamine_level0.44520894
95MP0003635_abnormal_synaptic_transmissio0.42985363
96MP0002063_abnormal_learning/memory/cond0.42750806
97MP0004782_abnormal_surfactant_physiolog0.41617189
98MP0004924_abnormal_behavior0.41589706
99MP0005386_behavior/neurological_phenoty0.41589706
100MP0000631_abnormal_neuroendocrine_gland0.40980331
101MP0005376_homeostasis/metabolism_phenot0.40955291
102MP0002067_abnormal_sensory_capabilities0.40801675
103MP0003880_abnormal_central_pattern0.39928329
104MP0009046_muscle_twitch0.38892059
105MP0009745_abnormal_behavioral_response0.37698937
106MP0004145_abnormal_muscle_electrophysio0.37021418
107MP0005620_abnormal_muscle_contractility0.35018822
108MP0010386_abnormal_urinary_bladder0.34729771
109MP0004085_abnormal_heartbeat0.32722410
110MP0000026_abnormal_inner_ear0.32491900
111MP0004142_abnormal_muscle_tone0.31357412
112MP0001661_extended_life_span0.30948881
113MP0005310_abnormal_salivary_gland0.30563389
114MP0004742_abnormal_vestibular_system0.28171128
115MP0004215_abnormal_myocardial_fiber0.28022507
116MP0001188_hyperpigmentation0.26470340
117MP0002108_abnormal_muscle_morphology0.25837473
118MP0002102_abnormal_ear_morphology0.24869640
119MP0000749_muscle_degeneration0.23901123
120MP0005595_abnormal_vascular_smooth0.21949003
121MP0008058_abnormal_DNA_repair0.20137877
122MP0001915_intracranial_hemorrhage0.19277723
123MP0002152_abnormal_brain_morphology0.19014569
124MP0003943_abnormal_hepatobiliary_system0.18894313
125MP0002928_abnormal_bile_duct0.18628811
126MP0005084_abnormal_gallbladder_morpholo0.18307556
127MP0008569_lethality_at_weaning0.18225408
128MP0002066_abnormal_motor_capabilities/c0.17994267
129MP0005076_abnormal_cell_differentiation0.17920326
130MP0001501_abnormal_sleep_pattern0.15970711
131MP0003890_abnormal_embryonic-extraembry0.14677430
132MP0002557_abnormal_social/conspecific_i0.14219488
133MP0000569_abnormal_digit_pigmentation0.13979596
134MP0001879_abnormal_lymphatic_vessel0.13207430
135MP0002184_abnormal_innervation0.12866313
136MP0002972_abnormal_cardiac_muscle0.12716137
137MP0009780_abnormal_chondrocyte_physiolo0.12550070
138MP0003638_abnormal_response/metabolism_0.12123062
139MP0000778_abnormal_nervous_system0.12079647
140MP0004811_abnormal_neuron_physiology0.11856587
141MP0000751_myopathy0.11508909
142MP0005193_abnormal_anterior_eye0.11330681
143MP0005248_abnormal_Harderian_gland0.11325229
144MP0005330_cardiomyopathy0.11054527
145MP0010368_abnormal_lymphatic_system0.11044606
146MP0001970_abnormal_pain_threshold0.11004269
147MP0003632_abnormal_nervous_system0.10859533

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.84600541
2Abnormal rod and cone electroretinograms (HP:0008323)9.44570297
3Pigmentary retinal degeneration (HP:0001146)9.24224437
4Abnormality of macular pigmentation (HP:0008002)8.41512150
5Central scotoma (HP:0000603)8.19371795
6Attenuation of retinal blood vessels (HP:0007843)7.91647311
7Chorioretinal atrophy (HP:0000533)7.54834853
8Scotoma (HP:0000575)7.33570358
9Pendular nystagmus (HP:0012043)7.20373418
10Decreased central vision (HP:0007663)6.45712201
11Photophobia (HP:0000613)6.01546978
12Abolished electroretinogram (ERG) (HP:0000550)5.93520562
13Type II diabetes mellitus (HP:0005978)5.61522823
14Vitreoretinal degeneration (HP:0000655)5.34293132
15Macular degeneration (HP:0000608)5.00749881
16Choroideremia (HP:0001139)4.79763802
17Severe visual impairment (HP:0001141)4.64522326
18Posterior subcapsular cataract (HP:0007787)4.54939858
19Cone-rod dystrophy (HP:0000548)4.48942985
20Retinitis pigmentosa (HP:0000510)4.45134065
21Keratoconus (HP:0000563)4.31305883
22Increased corneal curvature (HP:0100692)4.31305883
23Constricted visual fields (HP:0001133)4.08033976
24Decreased electroretinogram (ERG) amplitude (HP:0000654)3.42539387
25Type II lissencephaly (HP:0007260)3.30777835
26Congenital sensorineural hearing impairment (HP:0008527)3.09011065
27Progressive visual loss (HP:0000529)3.01212447
28Lipid accumulation in hepatocytes (HP:0006561)2.82711933
29Optic disc pallor (HP:0000543)2.81459882
30Retinal atrophy (HP:0001105)2.81455644
31Abnormality of the renal medulla (HP:0100957)2.81016116
32Subcapsular cataract (HP:0000523)2.78554034
33Tubular atrophy (HP:0000092)2.67512742
34Large for gestational age (HP:0001520)2.66115483
35Gait imbalance (HP:0002141)2.64374865
36Congenital primary aphakia (HP:0007707)2.62127474
37Rib fusion (HP:0000902)2.61057616
38Abnormality of the renal cortex (HP:0011035)2.58886841
39Retinal dysplasia (HP:0007973)2.57049674
40Polydipsia (HP:0001959)2.55865318
41Abnormal drinking behavior (HP:0030082)2.55865318
42Increased hepatocellular lipid droplets (HP:0006565)2.54379440
43Wide nasal bridge (HP:0000431)2.52984504
44Abnormality of alanine metabolism (HP:0010916)2.50645614
45Hyperalaninemia (HP:0003348)2.50645614
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50645614
47Mitochondrial inheritance (HP:0001427)2.46170410
48Acute necrotizing encephalopathy (HP:0006965)2.42852875
49Ketoacidosis (HP:0001993)2.39695821
50Increased CSF lactate (HP:0002490)2.37321931
51Nephrogenic diabetes insipidus (HP:0009806)2.35963790
52Limb dystonia (HP:0002451)2.33120498
53Hypothermia (HP:0002045)2.30462390
54Medial flaring of the eyebrow (HP:0010747)2.29721744
55Abnormal number of erythroid precursors (HP:0012131)2.28474969
56Inability to walk (HP:0002540)2.28459768
57Mesangial abnormality (HP:0001966)2.22665095
58Acute encephalopathy (HP:0006846)2.18873159
59Lissencephaly (HP:0001339)2.14822900
60Progressive macrocephaly (HP:0004481)2.13036133
61Polyuria (HP:0000103)2.11684654
62Concave nail (HP:0001598)2.11631244
63Patellar aplasia (HP:0006443)2.09884961
64Renal Fanconi syndrome (HP:0001994)2.03538356
65Renal cortical cysts (HP:0000803)2.02782140
66Poor coordination (HP:0002370)2.02396529
67Aplasia/Hypoplasia of the patella (HP:0006498)2.02250570
68Congenital stationary night blindness (HP:0007642)15.2804253
69Bony spicule pigmentary retinopathy (HP:0007737)11.5847396
70Dyschromatopsia (HP:0007641)11.0702036
71Hemiparesis (HP:0001269)1.98184066
72Hepatocellular necrosis (HP:0001404)1.96758213
73Male pseudohermaphroditism (HP:0000037)1.94595392
74Ketosis (HP:0001946)1.94006312
75Focal motor seizures (HP:0011153)1.93799557
76Progressive inability to walk (HP:0002505)1.92111287
77Abnormality of cells of the erythroid lineage (HP:0012130)1.91933914
78Abnormal mitochondria in muscle tissue (HP:0008316)1.90793374
79Abnormal albumin level (HP:0012116)1.90572047
80Hypoalbuminemia (HP:0003073)1.90572047
81Bile duct proliferation (HP:0001408)1.90448689
82Abnormal biliary tract physiology (HP:0012439)1.90448689
83Hypoplasia of the pons (HP:0012110)1.90198577
84Hepatic necrosis (HP:0002605)1.88698420
85Abnormality of the pons (HP:0007361)1.87450802
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87165139
87Decreased circulating renin level (HP:0003351)1.86643540
88Methylmalonic aciduria (HP:0012120)1.86033166
89Postaxial foot polydactyly (HP:0001830)1.85719218
90Focal seizures (HP:0007359)1.84471133
91Aplasia/Hypoplasia of the tibia (HP:0005772)1.83656813
92Aplasia/hypoplasia of the uterus (HP:0008684)1.81205756
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79277952
94Amelogenesis imperfecta (HP:0000705)1.78945613
95Oligodactyly (hands) (HP:0001180)1.78371675
96Vaginal atresia (HP:0000148)1.78339948
97Optic nerve hypoplasia (HP:0000609)1.77684208
98Increased serum lactate (HP:0002151)1.75826223
99Abnormality of the labia minora (HP:0012880)1.73998081
100Agitation (HP:0000713)1.73315190
101Genital tract atresia (HP:0001827)1.72494048
102Horizontal nystagmus (HP:0000666)1.72426638
103True hermaphroditism (HP:0010459)1.69843682
104Optic atrophy (HP:0000648)1.59670032
105Aplasia/Hypoplasia of the lens (HP:0008063)1.49631532
106Polar cataract (HP:0010696)1.43319370
107Pancreatic fibrosis (HP:0100732)1.39947451
108Severe Myopia (HP:0011003)1.38850669
109Dysdiadochokinesis (HP:0002075)1.35571657
110Febrile seizures (HP:0002373)1.32254543
111Epileptic encephalopathy (HP:0200134)1.29027914
112Astigmatism (HP:0000483)1.27285505
113Retinal detachment (HP:0000541)1.21429252
114Interstitial pulmonary disease (HP:0006530)1.21089894
115Broad foot (HP:0001769)1.13553781
116Pancreatic cysts (HP:0001737)1.10695856
117Chronic hepatic failure (HP:0100626)1.10248335
118Aplasia/Hypoplasia of the fovea (HP:0008060)1.07875858
119Hypoplasia of the fovea (HP:0007750)1.07875858
120Left ventricular hypertrophy (HP:0001712)1.07171388
121Progressive cerebellar ataxia (HP:0002073)1.05962135
122Cystic liver disease (HP:0006706)1.05720843
123Specific learning disability (HP:0001328)1.04094606
124Truncal ataxia (HP:0002078)1.03626147
125Abnormality of the fovea (HP:0000493)1.03305011
126Chorioretinal coloboma (HP:0000567)0.97958002
127Abnormality of dental color (HP:0011073)0.97193642
128Decreased testicular size (HP:0008734)0.96207471
129Asthma (HP:0002099)0.96048115
130Molar tooth sign on MRI (HP:0002419)0.94274882
131Abnormality of midbrain morphology (HP:0002418)0.94274882
132Aplasia/Hypoplasia of the tongue (HP:0010295)0.92475466
133Cerebellar dysplasia (HP:0007033)0.88825586
134Genetic anticipation (HP:0003743)0.87312752
135Recurrent sinusitis (HP:0011108)0.82999475
136Sclerocornea (HP:0000647)0.78526847
137Abnormality of the fingertips (HP:0001211)0.77907062
138Aplasia/Hypoplasia of the macula (HP:0008059)0.77901246
139Postaxial hand polydactyly (HP:0001162)0.77573703
140Short foot (HP:0001773)0.77014009
141Broad-based gait (HP:0002136)0.75931808
142Dental crowding (HP:0000678)0.75700928
143Hypermetropia (HP:0000540)0.75546065
144Nephronophthisis (HP:0000090)0.73452237
145Furrowed tongue (HP:0000221)0.70565880
146Hypodontia (HP:0000668)0.70487681
147Lymphopenia (HP:0001888)0.69315981
148Osteomalacia (HP:0002749)0.68038159
149Aqueductal stenosis (HP:0002410)0.67145408
150Prolonged QT interval (HP:0001657)0.67133083
151Gaze-evoked nystagmus (HP:0000640)0.67132918
152Hyperventilation (HP:0002883)0.66913257
153Congenital hepatic fibrosis (HP:0002612)0.66723369
154Partial agenesis of the corpus callosum (HP:0001338)0.66622453
155Corneal dystrophy (HP:0001131)0.66480080
156Anencephaly (HP:0002323)0.66045103
157Hirsutism (HP:0001007)0.65044112
158Aplasia/Hypoplasia affecting the retina (HP:0008061)0.64217801
159Nephrotic syndrome (HP:0000100)0.63233482
160Dysmetric saccades (HP:0000641)0.61878402
161Abnormality of cells of the lymphoid lineage (HP:0012140)0.61835426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK7.23376308
2BMPR1B2.90472947
3INSRR2.85527098
4MAP4K22.81852718
5ADRBK22.77647264
6PINK12.76142088
7WNK42.55814317
8WNK32.54114053
9TLK12.17487721
10ACVR1B2.04027593
11GRK110.2232519
12MAPK71.96264841
13ADRBK11.90004192
14IRAK21.88617397
15MAPK151.84874709
16BCKDK1.81741345
17CCNB11.80190214
18TAOK31.69681383
19OXSR11.66445979
20CAMK1G1.60457489
21BRD41.58925497
22CDK121.57569088
23DAPK21.57026584
24CAMK1D1.53412808
25MAPK121.51706671
26SIK21.46538138
27CDK191.42228267
28DYRK21.41176630
29AKT31.39752514
30STK391.32383955
31SGK21.30669815
32CAMKK21.22893926
33SGK2231.21905702
34SGK4941.21905702
35RPS6KA41.19642642
36PAK31.18246212
37CDK31.14661053
38STK381.12119094
39VRK11.09301993
40MST41.07887787
41MARK11.07573339
42LATS11.06706737
43EPHA41.05662675
44MAPKAPK51.04543934
45SGK31.02253902
46SIK30.99871932
47VRK20.99821667
48PASK0.98859943
49TRIM280.98692351
50MAP3K40.98673867
51ICK0.96877495
52MAP2K70.95572506
53CSNK1D0.95525060
54PRKCZ0.95468942
55MUSK0.93135108
56CSNK1G20.93062223
57HIPK20.92769128
58TIE10.91629151
59MKNK20.91457558
60MYLK0.90308064
61TTK0.90238611
62NME10.90018174
63TGFBR10.87863127
64CASK0.86668538
65CSNK1G30.85375031
66CSNK1G10.83805344
67PRKCE0.82797266
68FRK0.78731420
69WEE10.76825790
70NEK60.76462814
71PTK2B0.75844036
72PLK20.74235453
73PRKCH0.73890415
74PRPF4B0.73343634
75FGFR20.69749600
76ERBB20.67883815
77YES10.64638193
78PLK40.63647058
79DYRK1A0.63210760
80WNK10.63160361
81PRKAA20.63139325
82TXK0.62397052
83PLK10.61087710
84PRKAA10.59257573
85PHKG20.58452102
86PHKG10.58452102
87PRKCB0.57548338
88LIMK10.57328958
89CSNK1A1L0.57029307
90TNK20.56452864
91CAMK10.55587927
92PRKACG0.54799695
93CAMK2D0.54494971
94BUB10.53228567
95CHEK20.51508078
96SGK10.51489283
97TSSK60.51022436
98PAK60.50556648
99ZAK0.50230792
100STK38L0.48639194
101RPS6KA30.48357490
102PLK30.48081950
103AKT20.47336756
104PRKD30.46512606
105PNCK0.46378740
106MAPK130.46145216
107CAMKK10.45379681
108MAPKAPK30.43712343
109NEK20.43263374
110NTRK30.42664012
111FES0.42316880
112RPS6KB10.42273866
113MAP3K90.41717282
114SIK10.41146983
115PRKCI0.40911232
116GSK3B0.40611906
117NUAK10.40573587
118MAP3K100.40180392
119CSNK1A10.39711175
120MAPK140.39082669
121BRSK20.38519551
122UHMK10.38164494
123CAMK40.37960571
124TNIK0.37719356
125ERBB30.36962614
126PRKCA0.36466299
127PRKDC0.35734881
128RPS6KA50.35260270
129CHUK0.35220764
130CSNK1E0.35032817
131GRK50.34936600
132CAMK2A0.33899026
133BLK0.33770077
134STK30.33287429
135BCR0.33082625
136CDK50.32655398
137PRKACA0.32118952
138PRKCQ0.31828476
139PRKCG0.31741957
140MAPK90.31721171
141CDK90.31259820
142PIK3CA0.29342157
143MAPK100.29253695
144MAP3K130.28159425
145FGFR30.28052025
146PKN10.27687393
147MKNK10.27578875
148NTRK20.27279758
149CDK10.27227942
150PRKD20.26885208
151MAPK30.25838914
152STK110.25653497
153IRAK10.24812166
154MAP2K40.23678994

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.97837850
2Oxidative phosphorylation_Homo sapiens_hsa001902.68314823
3Linoleic acid metabolism_Homo sapiens_hsa005912.63744351
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.62355608
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.56826616
6Butanoate metabolism_Homo sapiens_hsa006502.24553140
7Parkinsons disease_Homo sapiens_hsa050122.06357193
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.05402972
9Selenocompound metabolism_Homo sapiens_hsa004502.02019890
10Phototransduction_Homo sapiens_hsa0474416.1773699
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97235208
12Protein export_Homo sapiens_hsa030601.92120122
13RNA polymerase_Homo sapiens_hsa030201.90178314
14Basal transcription factors_Homo sapiens_hsa030221.89460203
15Ether lipid metabolism_Homo sapiens_hsa005651.81046955
16Nitrogen metabolism_Homo sapiens_hsa009101.71133674
17Homologous recombination_Homo sapiens_hsa034401.66029243
18Tryptophan metabolism_Homo sapiens_hsa003801.58178513
19Regulation of autophagy_Homo sapiens_hsa041401.49658727
20Olfactory transduction_Homo sapiens_hsa047401.44175372
21Huntingtons disease_Homo sapiens_hsa050161.42924447
22Synaptic vesicle cycle_Homo sapiens_hsa047211.39145811
23Propanoate metabolism_Homo sapiens_hsa006401.29941777
24Sulfur relay system_Homo sapiens_hsa041221.28378412
25Alzheimers disease_Homo sapiens_hsa050101.26230130
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.23955903
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17234465
28Fanconi anemia pathway_Homo sapiens_hsa034601.10583334
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08740026
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08391119
31Peroxisome_Homo sapiens_hsa041461.07417633
32One carbon pool by folate_Homo sapiens_hsa006701.05172761
33Ribosome_Homo sapiens_hsa030101.02293281
34Arachidonic acid metabolism_Homo sapiens_hsa005901.01692715
35GABAergic synapse_Homo sapiens_hsa047270.94936052
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93408782
37Caffeine metabolism_Homo sapiens_hsa002320.89510026
38Steroid hormone biosynthesis_Homo sapiens_hsa001400.86856697
39Retinol metabolism_Homo sapiens_hsa008300.84590297
40Circadian rhythm_Homo sapiens_hsa047100.82352925
41Cyanoamino acid metabolism_Homo sapiens_hsa004600.76757387
42Metabolic pathways_Homo sapiens_hsa011000.76572811
43Sulfur metabolism_Homo sapiens_hsa009200.76158923
44Cholinergic synapse_Homo sapiens_hsa047250.75945991
45Chemical carcinogenesis_Homo sapiens_hsa052040.74520364
46Folate biosynthesis_Homo sapiens_hsa007900.73039123
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71786912
48Morphine addiction_Homo sapiens_hsa050320.71432106
49Fat digestion and absorption_Homo sapiens_hsa049750.71338287
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71202228
51Glutamatergic synapse_Homo sapiens_hsa047240.66395079
52Dopaminergic synapse_Homo sapiens_hsa047280.65942375
53Circadian entrainment_Homo sapiens_hsa047130.65514168
54Pyrimidine metabolism_Homo sapiens_hsa002400.64168469
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63714519
56Serotonergic synapse_Homo sapiens_hsa047260.63332113
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63047589
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62315861
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.60447789
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59742121
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59497926
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59356311
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59249125
64ABC transporters_Homo sapiens_hsa020100.58040130
65Steroid biosynthesis_Homo sapiens_hsa001000.57159429
66Arginine and proline metabolism_Homo sapiens_hsa003300.55519164
67Base excision repair_Homo sapiens_hsa034100.55183912
68Purine metabolism_Homo sapiens_hsa002300.55166750
69Proteasome_Homo sapiens_hsa030500.54889063
70Sphingolipid metabolism_Homo sapiens_hsa006000.51191879
71Long-term depression_Homo sapiens_hsa047300.50036346
72Nicotine addiction_Homo sapiens_hsa050330.49849566
73Hedgehog signaling pathway_Homo sapiens_hsa043400.49133512
74beta-Alanine metabolism_Homo sapiens_hsa004100.48116031
75Fatty acid degradation_Homo sapiens_hsa000710.47991405
76Insulin secretion_Homo sapiens_hsa049110.47875704
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46859037
78Vitamin B6 metabolism_Homo sapiens_hsa007500.45833114
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45085291
80Fatty acid metabolism_Homo sapiens_hsa012120.44253073
81Histidine metabolism_Homo sapiens_hsa003400.43924152
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42677927
83Pyruvate metabolism_Homo sapiens_hsa006200.41806021
84Glutathione metabolism_Homo sapiens_hsa004800.40729553
85Fatty acid biosynthesis_Homo sapiens_hsa000610.39423136
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37684517
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36614123
88Oxytocin signaling pathway_Homo sapiens_hsa049210.33739490
89cAMP signaling pathway_Homo sapiens_hsa040240.33218720
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33125951
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32951267
92Dilated cardiomyopathy_Homo sapiens_hsa054140.32137325
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28648862
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27920235
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27454216
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26494210
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.26350957
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26321585
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25637083
100Cocaine addiction_Homo sapiens_hsa050300.25177444
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24552062
102Renin secretion_Homo sapiens_hsa049240.24053845
103Inositol phosphate metabolism_Homo sapiens_hsa005620.23996857
104Fructose and mannose metabolism_Homo sapiens_hsa000510.23979791
105Salivary secretion_Homo sapiens_hsa049700.22052944
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21899765
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21706861
108mTOR signaling pathway_Homo sapiens_hsa041500.21657860
109Gastric acid secretion_Homo sapiens_hsa049710.21425734
110Calcium signaling pathway_Homo sapiens_hsa040200.21126658
111Lysine degradation_Homo sapiens_hsa003100.20932726
112Cardiac muscle contraction_Homo sapiens_hsa042600.20240817
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19923736
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19421822
115Chemokine signaling pathway_Homo sapiens_hsa040620.19262213
116Type II diabetes mellitus_Homo sapiens_hsa049300.19259647
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19104754
118Glycerolipid metabolism_Homo sapiens_hsa005610.18711266
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.18671072
120Fatty acid elongation_Homo sapiens_hsa000620.17710320
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.17703645
122Long-term potentiation_Homo sapiens_hsa047200.15752207
123Galactose metabolism_Homo sapiens_hsa000520.15335177
124Taste transduction_Homo sapiens_hsa047420.14941884
125Arginine biosynthesis_Homo sapiens_hsa002200.14610516
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14147935
127HIF-1 signaling pathway_Homo sapiens_hsa040660.13604656
128Glucagon signaling pathway_Homo sapiens_hsa049220.13544435
129Amphetamine addiction_Homo sapiens_hsa050310.12525287
130Ras signaling pathway_Homo sapiens_hsa040140.12064371
131Alcoholism_Homo sapiens_hsa050340.12041251
132MAPK signaling pathway_Homo sapiens_hsa040100.10317311
133Ovarian steroidogenesis_Homo sapiens_hsa049130.08352904
134AMPK signaling pathway_Homo sapiens_hsa041520.08211940
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.08209713
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07959985
137Vitamin digestion and absorption_Homo sapiens_hsa049770.07391009
138Mineral absorption_Homo sapiens_hsa049780.07147079
139Collecting duct acid secretion_Homo sapiens_hsa049660.06771727
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.06586030
141GnRH signaling pathway_Homo sapiens_hsa049120.05954842
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.05752823
143Wnt signaling pathway_Homo sapiens_hsa043100.05499288
144Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.05196152
145Pancreatic secretion_Homo sapiens_hsa049720.03685201
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.03194945
147RNA degradation_Homo sapiens_hsa030180.03186709
148ErbB signaling pathway_Homo sapiens_hsa040120.03011546
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.02902953
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.02499523
151Choline metabolism in cancer_Homo sapiens_hsa052310.02374965
152Glioma_Homo sapiens_hsa052140.02231057
153Rheumatoid arthritis_Homo sapiens_hsa053230.02205236
154Insulin resistance_Homo sapiens_hsa049310.01908568
155Tight junction_Homo sapiens_hsa045300.01830684
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.01821665
157Hippo signaling pathway_Homo sapiens_hsa043900.01412374
158Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.01059841
159mRNA surveillance pathway_Homo sapiens_hsa030150.00804511
160Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.00758335
161Thyroid hormone synthesis_Homo sapiens_hsa049180.00396116
162Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0039083
163Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0032931

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »