RSPO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of branching involved in prostate gland morphogenesis (GO:0060687)9.31584014
2prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060528.28487151
3mesenchymal-epithelial cell signaling (GO:0060638)7.39812177
4cellular response to vitamin D (GO:0071305)7.33203456
5negative regulation of osteoblast proliferation (GO:0033689)6.91123310
6lateral sprouting from an epithelium (GO:0060601)6.74797935
7regulation of branching involved in salivary gland morphogenesis (GO:0060693)6.32431645
8COPI coating of Golgi vesicle (GO:0048205)6.17638996
9Golgi transport vesicle coating (GO:0048200)6.17638996
10radial glial cell differentiation (GO:0060019)5.79747080
11negative regulation of JUN kinase activity (GO:0043508)5.77094604
12bone trabecula formation (GO:0060346)5.77053677
13somite development (GO:0061053)5.69495778
14type B pancreatic cell development (GO:0003323)5.64381147
15branching involved in prostate gland morphogenesis (GO:0060442)5.58794941
16peptide hormone processing (GO:0016486)5.25675413
17regulation of non-canonical Wnt signaling pathway (GO:2000050)5.16643312
18cellular response to vitamin (GO:0071295)5.06587905
19convergent extension (GO:0060026)5.02735313
20dorsal/ventral axis specification (GO:0009950)5.01002332
21negative regulation of bone remodeling (GO:0046851)4.98997586
22keratinocyte proliferation (GO:0043616)4.94610633
23branching involved in labyrinthine layer morphogenesis (GO:0060670)4.94226945
24glandular epithelial cell development (GO:0002068)4.91832364
25regulation of gene silencing by RNA (GO:0060966)4.87339288
26regulation of posttranscriptional gene silencing (GO:0060147)4.87339288
27regulation of gene silencing by miRNA (GO:0060964)4.87339288
28negative regulation of gluconeogenesis (GO:0045721)4.82651336
29regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.82336609
30planar cell polarity pathway involved in neural tube closure (GO:0090179)4.79015812
31paraxial mesoderm development (GO:0048339)4.78208694
32neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.77248325
33chromosome condensation (GO:0030261)4.66994307
34cellular response to prostaglandin stimulus (GO:0071379)4.61020140
35regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.58827722
36craniofacial suture morphogenesis (GO:0097094)4.56125021
37cell proliferation involved in kidney development (GO:0072111)4.52255566
38cell proliferation involved in metanephros development (GO:0072203)4.51614831
39establishment of apical/basal cell polarity (GO:0035089)4.47513760
40pre-miRNA processing (GO:0031054)4.42907404
41negative regulation of fibroblast apoptotic process (GO:2000270)4.41261545
42protein maturation by protein folding (GO:0022417)4.35580588
43establishment of planar polarity (GO:0001736)4.26528757
44establishment of tissue polarity (GO:0007164)4.26528757
45negative regulation of tissue remodeling (GO:0034104)4.23434637
46artery smooth muscle contraction (GO:0014824)4.19777013
47single strand break repair (GO:0000012)4.18142014
48heterochromatin organization (GO:0070828)4.17988418
49acrosome reaction (GO:0007340)4.17793311
50DNA packaging (GO:0006323)4.15826349
51prostate gland epithelium morphogenesis (GO:0060740)4.13959691
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.08852897
53COPII vesicle coating (GO:0048208)4.08144775
54regulation of systemic arterial blood pressure by hormone (GO:0001990)4.02977558
55regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.02977558
56endocrine process (GO:0050886)4.02977558
57positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.99477269
58cellular response to cholesterol (GO:0071397)3.98615180
59outer ear morphogenesis (GO:0042473)3.95648046
60chromatin silencing (GO:0006342)3.93413683
61pharyngeal system development (GO:0060037)3.91713594
62columnar/cuboidal epithelial cell development (GO:0002066)3.90781389
63exocrine pancreas development (GO:0031017)3.89969199
64renal system development (GO:0072001)3.89694153
65branch elongation of an epithelium (GO:0060602)3.85725523
66endocrine pancreas development (GO:0031018)3.81488284
67establishment of monopolar cell polarity (GO:0061162)3.79046890
68establishment or maintenance of monopolar cell polarity (GO:0061339)3.79046890
69regulation of keratinocyte proliferation (GO:0010837)3.71671212
70branching involved in salivary gland morphogenesis (GO:0060445)3.69279227
71mesenchymal cell proliferation (GO:0010463)3.69277846
72neuronal ion channel clustering (GO:0045161)3.66480779
73mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.66098977
74response to prostaglandin E (GO:0034695)3.64840431
75tonic smooth muscle contraction (GO:0014820)3.63677889
76notochord development (GO:0030903)3.63609807
77regulation of osteoblast proliferation (GO:0033688)3.62139998
78glandular epithelial cell differentiation (GO:0002067)3.59435561
79protein retention in ER lumen (GO:0006621)3.57627723
80hematopoietic stem cell differentiation (GO:0060218)3.56341915
81otic vesicle formation (GO:0030916)3.55961954
82axis elongation (GO:0003401)3.54891121
83cranial suture morphogenesis (GO:0060363)3.54505365
84mesenchymal cell differentiation (GO:0048762)3.53885436
85retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.52927482
86L-alpha-amino acid transmembrane transport (GO:1902475)3.51192363
87regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.48621723
88protein-DNA complex disassembly (GO:0032986)3.42338860
89nucleosome disassembly (GO:0006337)3.42338860
90lung-associated mesenchyme development (GO:0060484)3.41379143
91cochlea morphogenesis (GO:0090103)3.40252652
92sperm motility (GO:0030317)3.39866104
93fusion of sperm to egg plasma membrane (GO:0007342)3.39023835
94genitalia morphogenesis (GO:0035112)3.36546270
95establishment of integrated proviral latency (GO:0075713)3.36334522
96glomerular visceral epithelial cell development (GO:0072015)3.34347545
97activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.31622045
98signal peptide processing (GO:0006465)3.25379361
99negative regulation of insulin secretion (GO:0046676)3.25095188
100digestive tract morphogenesis (GO:0048546)3.23974669
101cellular response to sterol (GO:0036315)3.22020659
102vesicle coating (GO:0006901)3.19268804
103induction of positive chemotaxis (GO:0050930)3.17196658
104sequestering of extracellular ligand from receptor (GO:0035581)3.17057276
105negative regulation of multicellular organism growth (GO:0040015)3.16657457
106regulation of type B pancreatic cell apoptotic process (GO:2000674)3.15998833
107mammary gland epithelial cell differentiation (GO:0060644)3.15161347
108glomerular epithelial cell development (GO:0072310)3.14697192
109positive regulation of fat cell differentiation (GO:0045600)3.14547168
110hair follicle morphogenesis (GO:0031069)3.14046004
111cellular response to nutrient (GO:0031670)3.13898834
112regulation of smoothened signaling pathway (GO:0008589)3.12936836
113positive regulation of nuclease activity (GO:0032075)3.12228852
114phenol-containing compound catabolic process (GO:0019336)3.11341249
115protein complex localization (GO:0031503)3.10152878
116response to follicle-stimulating hormone (GO:0032354)3.07950800
117microtubule depolymerization (GO:0007019)3.06872262
118sensory perception of taste (GO:0050909)3.06572430
119Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.05721628
120non-canonical Wnt signaling pathway (GO:0035567)3.05165617
121sperm capacitation (GO:0048240)3.04774374
122prostate gland growth (GO:0060736)3.04440643
123insulin secretion (GO:0030073)3.04394113
124rRNA methylation (GO:0031167)3.04325357
125polarized epithelial cell differentiation (GO:0030859)3.04261603
126sequestering of metal ion (GO:0051238)3.03703552
127regulation of systemic arterial blood pressure (GO:0003073)3.03588664
128regulation of morphogenesis of a branching structure (GO:0060688)3.03365827
129spermatid nucleus differentiation (GO:0007289)3.03305018
130regulation of establishment of planar polarity (GO:0090175)3.00967756
131microtubule polymerization or depolymerization (GO:0031109)3.00916020
132positive regulation of hormone biosynthetic process (GO:0046886)2.99337939
133negative regulation of osteoblast differentiation (GO:0045668)2.99207031
134binding of sperm to zona pellucida (GO:0007339)2.99040190
135negative regulation of smoothened signaling pathway (GO:0045879)2.98957720
136response to vitamin D (GO:0033280)2.94182241
137positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.93458608
138positive regulation of cell cycle G2/M phase transition (GO:1902751)2.93458608
139intestinal epithelial cell development (GO:0060576)2.93107914
140histone arginine methylation (GO:0034969)2.92185514
141organ growth (GO:0035265)2.91465528
142hormone catabolic process (GO:0042447)2.90527571
143hippo signaling (GO:0035329)2.90399727
144spermatid development (GO:0007286)2.89418861
145endothelial cell chemotaxis (GO:0035767)2.85415962
146rRNA modification (GO:0000154)2.83414609
147negative regulation of translation, ncRNA-mediated (GO:0040033)2.79376316
148regulation of translation, ncRNA-mediated (GO:0045974)2.79376316
149negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79376316
150regulation of cell fate specification (GO:0042659)2.76208080
151regulation of stem cell maintenance (GO:2000036)2.72358946
152regulation of G0 to G1 transition (GO:0070316)2.71943978
153negative regulation of gene silencing (GO:0060969)2.71545423
154regulation of short-term neuronal synaptic plasticity (GO:0048172)2.71163429
155mesenchymal to epithelial transition (GO:0060231)2.70605590
156negative regulation of gene expression, epigenetic (GO:0045814)2.68229857
157microtubule severing (GO:0051013)2.65258034
158sperm-egg recognition (GO:0035036)2.62477131
159negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.62358925
160establishment or maintenance of bipolar cell polarity (GO:0061245)2.61663421
161establishment or maintenance of apical/basal cell polarity (GO:0035088)2.61663421
162establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.61273676
163nuclear pore complex assembly (GO:0051292)2.60527169
164somatic stem cell division (GO:0048103)2.59415968
165peptidyl-arginine omega-N-methylation (GO:0035247)2.57769913
166establishment of viral latency (GO:0019043)2.56609996
167response to pheromone (GO:0019236)2.54781409
168negative regulation of cell fate specification (GO:0009996)2.50861721
1694-hydroxyproline metabolic process (GO:0019471)2.50834417
170generation of neurons (GO:0048699)2.49868582
171regulation of transcription involved in cell fate commitment (GO:0060850)2.49689238
172G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.47501279
173cytoskeletal anchoring at plasma membrane (GO:0007016)2.46096184
174embryonic body morphogenesis (GO:0010172)2.43278125
175plasma membrane fusion (GO:0045026)2.41574761
176ATP-dependent chromatin remodeling (GO:0043044)2.41103767
177embryonic camera-type eye development (GO:0031076)2.40780143
178negative regulation of androgen receptor signaling pathway (GO:0060766)2.37804198
179positive regulation of catenin import into nucleus (GO:0035413)2.37564948
180kidney mesenchyme development (GO:0072074)2.36181555
181DNA unwinding involved in DNA replication (GO:0006268)2.34727669
182negative regulation of chondrocyte differentiation (GO:0032331)2.33062966
183mesenchymal cell differentiation involved in kidney development (GO:0072161)2.30261371
184mesenchymal cell differentiation involved in renal system development (GO:2001012)2.30261371
185inner ear receptor cell development (GO:0060119)2.28821910
186neural tube development (GO:0021915)2.28458588
187cellular protein complex localization (GO:0034629)2.26975762
188L-serine metabolic process (GO:0006563)2.26129597
189sexual reproduction (GO:0019953)2.26105525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.92904186
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.74086054
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.68158333
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.58683866
5E2F7_22180533_ChIP-Seq_HELA_Human3.05268247
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.86395226
7ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.74169830
8* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.35877002
9GATA1_22025678_ChIP-Seq_K562_Human2.33578703
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.30266027
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.28234773
12CTCF_27219007_Chip-Seq_Bcells_Human2.21249826
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18545571
14ERG_21242973_ChIP-ChIP_JURKAT_Human2.16401768
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.10155398
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.10155398
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.10155398
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.09866546
19EZH2_22144423_ChIP-Seq_EOC_Human2.09686047
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09153906
21GBX2_23144817_ChIP-Seq_PC3_Human2.03817457
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.02061751
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00069567
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.99790832
25TBX3_20139965_ChIP-Seq_MESCs_Mouse1.97725430
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93007698
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90701013
28TBX3_20139965_ChIP-Seq_ESCs_Mouse1.89756099
29LXR_22292898_ChIP-Seq_THP-1_Human1.87170340
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.86510616
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.85240788
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78537782
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.77641973
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75696004
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.75369091
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.74480649
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73813897
38* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71038891
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.70988609
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67800993
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67002899
42* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66669934
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66498742
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66136640
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62944395
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62851919
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62495223
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.62043339
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.61732026
50VDR_22108803_ChIP-Seq_LS180_Human1.61595324
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.58003107
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56521462
53SMC4_20622854_ChIP-Seq_HELA_Human1.56325167
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54944504
55STAT3_23295773_ChIP-Seq_U87_Human1.54664265
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.53430802
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.51777050
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.51642289
59AHR_22903824_ChIP-Seq_MCF-7_Human1.50985335
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50914126
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.49569004
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49389239
63YAP1_20516196_ChIP-Seq_MESCs_Mouse1.47746384
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47739084
65BCAT_22108803_ChIP-Seq_LS180_Human1.47257935
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46164945
67* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45977844
68P300_19829295_ChIP-Seq_ESCs_Human1.45643835
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43831769
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43423051
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.42809985
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.42721461
73P68_20966046_ChIP-Seq_HELA_Human1.39573051
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.38116937
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38111949
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37518648
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37389089
78KDM2B_26808549_Chip-Seq_K562_Human1.35556312
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34427650
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.33824650
81DROSHA_22980978_ChIP-Seq_HELA_Human1.32967448
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.32750810
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32622472
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.31439220
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30924326
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30924326
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30341301
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30229723
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28160597
90WT1_19549856_ChIP-ChIP_CCG9911_Human1.27952732
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24894586
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24735134
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24231372
94NANOG_21062744_ChIP-ChIP_HESCs_Human1.23359320
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22531248
96NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22051796
97* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20565497
98JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20549803
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.19428062
100TET1_21490601_ChIP-Seq_MESCs_Mouse1.19263799
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.19017144
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.17478015
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16915900
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16764957
105EP300_21415370_ChIP-Seq_HL-1_Mouse1.16102933
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16030619
107POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15654825
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15226176
109SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15104511
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14517199
111IGF1R_20145208_ChIP-Seq_DFB_Human1.13851561
112NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13813944
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13763015
114NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13362177
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13362177
116EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12942198
117SOX2_16153702_ChIP-ChIP_HESCs_Human1.12516488
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12471262
119SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10670371
120SA1_27219007_Chip-Seq_Bcells_Human1.09505741
121CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09194986
122* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08651389
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07977421
124TRIM28_21343339_ChIP-Seq_HEK293_Human1.07875403
125AR_19668381_ChIP-Seq_PC3_Human1.07594413
126RACK7_27058665_Chip-Seq_MCF-7_Human1.07072354
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06909530
128PHF8_20622854_ChIP-Seq_HELA_Human1.06876343
129RXR_22108803_ChIP-Seq_LS180_Human1.06614219
130* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06306518
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05147417
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05147417
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05055221
134NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04688957
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02803178
136TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02478553
137RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02349264
138CTCF_20526341_ChIP-Seq_ESCs_Human1.01795875
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01358322
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01303424
141NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01263909
142FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01107004
143OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01029732
144CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00988821
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00909616
146EGR1_19374776_ChIP-ChIP_THP-1_Human1.00499619
147TCF4_23295773_ChIP-Seq_U87_Human1.00139033
148* RUNX2_22187159_ChIP-Seq_PCA_Human0.99541144
149* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98989674
150FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98210793
151AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97941907
152E2F1_20622854_ChIP-Seq_HELA_Human0.97679307
153ELK3_25401928_ChIP-Seq_HUVEC_Human0.96972305
154CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96762960
155MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96548231
156POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.96185598
157KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95780078
158TP63_22573176_ChIP-Seq_HFKS_Human0.95643121
159AR_21572438_ChIP-Seq_LNCaP_Human0.95103754
160* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94814435
161TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93708939
162TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93673005
163TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92624523
164SMAD3_21741376_ChIP-Seq_ESCs_Human0.91742268
165SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91613296
166SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91418204
167PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91267221
168SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91136754
169RING1B_27294783_Chip-Seq_NPCs_Mouse0.90847279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005187_abnormal_penis_morphology5.48762429
2MP0003878_abnormal_ear_physiology5.12133238
3MP0005377_hearing/vestibular/ear_phenot5.12133238
4MP0001661_extended_life_span4.28235831
5MP0002938_white_spotting3.88327582
6MP0001299_abnormal_eye_distance/3.27243659
7MP0005248_abnormal_Harderian_gland3.16882984
8MP0005503_abnormal_tendon_morphology3.09860035
9MP0001348_abnormal_lacrimal_gland2.93178870
10MP0003283_abnormal_digestive_organ2.92385620
11MP0005220_abnormal_exocrine_pancreas2.90783015
12MP0009780_abnormal_chondrocyte_physiolo2.90649403
13MP0004272_abnormal_basement_membrane2.82723025
14MP0001944_abnormal_pancreas_morphology2.79778163
15MP0002693_abnormal_pancreas_physiology2.77630523
16MP0005410_abnormal_fertilization2.65471147
17MP0005257_abnormal_intraocular_pressure2.65161088
18MP0004858_abnormal_nervous_system2.50847753
19MP0002822_catalepsy2.50583587
20MP0003941_abnormal_skin_development2.45627413
21MP0003705_abnormal_hypodermis_morpholog2.40110474
22MP0000428_abnormal_craniofacial_morphol2.38042820
23MP0005379_endocrine/exocrine_gland_phen2.37103741
24MP0002877_abnormal_melanocyte_morpholog2.36831212
25MP0000566_synostosis2.25745460
26MP0000462_abnormal_digestive_system2.08486526
27MP0002909_abnormal_adrenal_gland2.05930555
28MP0000427_abnormal_hair_cycle1.99752933
29MP0002254_reproductive_system_inflammat1.98598704
30MP0006276_abnormal_autonomic_nervous1.90851829
31MP0004043_abnormal_pH_regulation1.84912980
32MP0003693_abnormal_embryo_hatching1.78005369
33MP0000013_abnormal_adipose_tissue1.75966418
34MP0002896_abnormal_bone_mineralization1.74222994
35MP0000647_abnormal_sebaceous_gland1.66006374
36MP0003122_maternal_imprinting1.65718778
37MP0000049_abnormal_middle_ear1.64528015
38MP0000639_abnormal_adrenal_gland1.64461260
39MP0009053_abnormal_anal_canal1.62701295
40MP0010386_abnormal_urinary_bladder1.60826992
41MP0001293_anophthalmia1.59769096
42MP0000579_abnormal_nail_morphology1.58620176
43MP0002108_abnormal_muscle_morphology1.58389992
44MP0009250_abnormal_appendicular_skeleto1.58350935
45MP0004957_abnormal_blastocyst_morpholog1.55062145
46MP0003183_abnormal_peptide_metabolism1.54921266
47MP0006072_abnormal_retinal_apoptosis1.51394897
48MP0006292_abnormal_olfactory_placode1.49056007
49MP0005367_renal/urinary_system_phenotyp1.47818410
50MP0000516_abnormal_urinary_system1.47818410
51MP0001849_ear_inflammation1.47360706
52MP0002249_abnormal_larynx_morphology1.45642566
53MP0005423_abnormal_somatic_nervous1.44217016
54MP0003959_abnormal_lean_body1.43475371
55MP0000678_abnormal_parathyroid_gland1.43394431
56MP0004134_abnormal_chest_morphology1.42491873
57MP0010030_abnormal_orbit_morphology1.40246253
58MP0003718_maternal_effect1.39673413
59MP0005670_abnormal_white_adipose1.39359687
60MP0010352_gastrointestinal_tract_polyps1.37366197
61MP0000537_abnormal_urethra_morphology1.34922001
62MP0004859_abnormal_synaptic_plasticity1.34895470
63MP0002078_abnormal_glucose_homeostasis1.34782017
64MP0002697_abnormal_eye_size1.34174944
65MP0004133_heterotaxia1.31595796
66MP0000762_abnormal_tongue_morphology1.30274658
67MP0000003_abnormal_adipose_tissue1.29635152
68MP0001502_abnormal_circadian_rhythm1.29426246
69MP0003942_abnormal_urinary_system1.29096286
70MP0003195_calcinosis1.27807452
71MP0003136_yellow_coat_color1.27443366
72MP0003111_abnormal_nucleus_morphology1.24259862
73MP0002085_abnormal_embryonic_tissue1.23593330
74MP0001346_abnormal_lacrimal_gland1.23105835
75MP0010307_abnormal_tumor_latency1.22559655
76MP0003115_abnormal_respiratory_system1.22242349
77MP0002796_impaired_skin_barrier1.19884113
78MP0008932_abnormal_embryonic_tissue1.19535997
79MP0008775_abnormal_heart_ventricle1.19413755
80MP0010368_abnormal_lymphatic_system1.19331951
81MP0003698_abnormal_male_reproductive1.19214047
82MP0003077_abnormal_cell_cycle1.18123783
83MP0002295_abnormal_pulmonary_circulatio1.15419749
84MP0003567_abnormal_fetal_cardiomyocyte1.15135206
85MP0000613_abnormal_salivary_gland1.14757415
86MP0002116_abnormal_craniofacial_bone1.14152419
87MP0003861_abnormal_nervous_system1.13503639
88MP0001730_embryonic_growth_arrest1.13384307
89MP0001485_abnormal_pinna_reflex1.12639858
90MP0003868_abnormal_feces_composition1.11593596
91MP0002177_abnormal_outer_ear1.11023426
92MP0002837_dystrophic_cardiac_calcinosis1.09076697
93MP0005075_abnormal_melanosome_morpholog1.08617414
94MP0004233_abnormal_muscle_weight1.06696935
95MP0005623_abnormal_meninges_morphology1.05132293
96MP0008438_abnormal_cutaneous_collagen1.03880661
97MP0003566_abnormal_cell_adhesion1.03470076
98MP0005508_abnormal_skeleton_morphology1.01661164
99MP0003300_gastrointestinal_ulcer1.01316281
100MP0001188_hyperpigmentation1.00738074
101MP0002084_abnormal_developmental_patter1.00721077
102MP0001984_abnormal_olfaction1.00246873
103MP0000371_diluted_coat_color0.99632725
104MP0000026_abnormal_inner_ear0.99178327
105MP0002098_abnormal_vibrissa_morphology0.98737548
106MP0003755_abnormal_palate_morphology0.98107497
107MP0001501_abnormal_sleep_pattern0.96841996
108MP0001986_abnormal_taste_sensitivity0.94720417
109MP0001756_abnormal_urination0.94521616
110MP0004270_analgesia0.94199981
111MP0003935_abnormal_craniofacial_develop0.94116387
112MP0003119_abnormal_digestive_system0.93415338
113MP0002111_abnormal_tail_morphology0.92792245
114MP0002751_abnormal_autonomic_nervous0.90109025
115MP0003890_abnormal_embryonic-extraembry0.88128334
116MP0002733_abnormal_thermal_nociception0.87423306
117MP0001286_abnormal_eye_development0.87193343
118MP0001765_abnormal_ion_homeostasis0.87178111
119MP0000163_abnormal_cartilage_morphology0.87164105
120MP0000432_abnormal_head_morphology0.86883816
121MP0002109_abnormal_limb_morphology0.86024073
122MP0001905_abnormal_dopamine_level0.85910433
123MP0000534_abnormal_ureter_morphology0.84227319
124MP0001270_distended_abdomen0.83453019
125MP0002735_abnormal_chemical_nociception0.82425992
126MP0005275_abnormal_skin_tensile0.82155812
127MP0002161_abnormal_fertility/fecundity0.81843408
128MP0005645_abnormal_hypothalamus_physiol0.81548342
129MP0005595_abnormal_vascular_smooth0.81464848
130MP0005380_embryogenesis_phenotype0.80906253
131MP0001672_abnormal_embryogenesis/_devel0.80906253
132MP0001440_abnormal_grooming_behavior0.80797169
133MP0001929_abnormal_gametogenesis0.80785696
134MP0001486_abnormal_startle_reflex0.79873341
135MP0002168_other_aberrant_phenotype0.79695477
136MP0003938_abnormal_ear_development0.79544753
137MP0005646_abnormal_pituitary_gland0.79472587
138MP0002282_abnormal_trachea_morphology0.78877406
139MP0009643_abnormal_urine_homeostasis0.78592902
140MP0008961_abnormal_basal_metabolism0.78065255
141MP0002115_abnormal_skeleton_extremities0.77311497
142MP0000751_myopathy0.77041273
143MP0004264_abnormal_extraembryonic_tissu0.76997592
144MP0002081_perinatal_lethality0.76552361
145MP0000733_abnormal_muscle_development0.76487577
146MP0000631_abnormal_neuroendocrine_gland0.75976260
147MP0003385_abnormal_body_wall0.75945985
148MP0002009_preneoplasia0.75172402
149MP0008770_decreased_survivor_rate0.74231197
150MP0003252_abnormal_bile_duct0.73945771
151MP0002080_prenatal_lethality0.73618827
152MP0009046_muscle_twitch0.72972769
153MP0003879_abnormal_hair_cell0.72749764
154MP0004197_abnormal_fetal_growth/weight/0.72701750
155MP0004885_abnormal_endolymph0.72622152
156MP0005535_abnormal_body_temperature0.72515184
157MP0002572_abnormal_emotion/affect_behav0.72308876
158MP0001340_abnormal_eyelid_morphology0.71905223
159MP0009672_abnormal_birth_weight0.70885886
160MP0003635_abnormal_synaptic_transmissio0.70792497
161MP0003943_abnormal_hepatobiliary_system0.70604965
162MP0009703_decreased_birth_body0.70436153
163MP0003953_abnormal_hormone_level0.69423368
164MP0002928_abnormal_bile_duct0.68872877
165MP0000955_abnormal_spinal_cord0.68847046
166MP0002114_abnormal_axial_skeleton0.67964516
167MP0003937_abnormal_limbs/digits/tail_de0.67592305
168MP0001243_abnormal_dermal_layer0.65621560
169MP0002089_abnormal_postnatal_growth/wei0.64995337
170MP0008877_abnormal_DNA_methylation0.62202662

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the parietal bone (HP:0002696)7.19983054
2Midline defect of the nose (HP:0004122)6.35234914
3Neoplasm of the heart (HP:0100544)5.51320431
4Short 4th metacarpal (HP:0010044)5.46090250
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.46090250
6Broad face (HP:0000283)4.92347238
7Abnormality of the diencephalon (HP:0010662)4.82401798
8Toxemia of pregnancy (HP:0100603)4.70246858
9Trigonocephaly (HP:0000243)4.67036158
10Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.51733833
11Nasolacrimal duct obstruction (HP:0000579)4.06422423
12Anteriorly placed anus (HP:0001545)3.99983949
13Abnormality of the nasal septum (HP:0000419)3.98455879
14Alacrima (HP:0000522)3.83409452
15Hyperinsulinemic hypoglycemia (HP:0000825)3.82721484
16Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.77643292
17Hypoglycemic seizures (HP:0002173)3.75569096
18Severe visual impairment (HP:0001141)3.74609794
19Abnormality of the 4th metacarpal (HP:0010012)3.71621448
20Symptomatic seizures (HP:0011145)3.68595666
21Abnormality of the distal phalanx of the thumb (HP:0009617)3.41603375
22Short phalanx of the thumb (HP:0009660)3.37405870
23Selective tooth agenesis (HP:0001592)3.23134625
24Abnormality of the lacrimal duct (HP:0011481)3.22755703
25Aplasia involving bones of the upper limbs (HP:0009823)3.12849968
26Aplasia of the phalanges of the hand (HP:0009802)3.12849968
27Aplasia involving bones of the extremities (HP:0009825)3.12849968
28Exostoses (HP:0100777)3.12353289
29Neoplasm of the oral cavity (HP:0100649)3.10321770
30Hyperglycemia (HP:0003074)3.04585470
31Depressed nasal tip (HP:0000437)3.02202026
32Abnormality of the nasolacrimal system (HP:0000614)3.01820435
33Hypoglycemic coma (HP:0001325)2.99030961
34Hypoplastic labia majora (HP:0000059)2.98768089
35Genetic anticipation (HP:0003743)2.97344856
36Decreased lacrimation (HP:0000633)2.97219002
37Insulin-resistant diabetes mellitus (HP:0000831)2.87274610
38Broad metatarsal (HP:0001783)2.80737356
39Turricephaly (HP:0000262)2.79960916
40Premature rupture of membranes (HP:0001788)2.78275223
41Bell-shaped thorax (HP:0001591)2.73905303
42Dysmetric saccades (HP:0000641)2.72111144
43Abnormal number of incisors (HP:0011064)2.69692620
44Flat capital femoral epiphysis (HP:0003370)2.67506744
45Choanal stenosis (HP:0000452)2.64921498
46Down-sloping shoulders (HP:0200021)2.64179789
47Abnormality of the labia majora (HP:0012881)2.63699217
48Bilateral microphthalmos (HP:0007633)2.61217901
49Abnormality of the incisor (HP:0000676)2.55427218
50Abnormality of dentin (HP:0010299)2.53638307
51Partial duplication of thumb phalanx (HP:0009944)2.53009483
52Abnormality of calcium-phosphate metabolism (HP:0100530)2.52709838
53Partial duplication of the phalanx of hand (HP:0009999)2.47686165
54Large earlobe (HP:0009748)2.46309358
55Hepatoblastoma (HP:0002884)2.41761782
56Ectopia lentis (HP:0001083)2.39045751
57Medulloblastoma (HP:0002885)2.38625045
58Polyphagia (HP:0002591)2.38437158
59Abnormality of incisor morphology (HP:0011063)2.35884766
60Mixed hearing impairment (HP:0000410)2.35844021
61Shallow orbits (HP:0000586)2.34805225
62Abnormality of endocrine pancreas physiology (HP:0012093)2.34560966
63Abnormality of the pancreatic islet cells (HP:0006476)2.34560966
64Maternal diabetes (HP:0009800)2.31443053
65Supernumerary ribs (HP:0005815)2.30950803
66Deformed sella turcica (HP:0002681)2.30917589
67Abnormality of the labia minora (HP:0012880)2.30129036
68Chronic bronchitis (HP:0004469)2.29399464
69Septo-optic dysplasia (HP:0100842)2.26919567
70White forelock (HP:0002211)2.25299507
71Aplasia cutis congenita (HP:0001057)2.25119793
72Recurrent corneal erosions (HP:0000495)2.23800953
73Glioma (HP:0009733)2.22169025
74Rectovaginal fistula (HP:0000143)2.18991802
75Rectal fistula (HP:0100590)2.18991802
76Intestinal fistula (HP:0100819)2.17078411
77Agitation (HP:0000713)2.15938434
78Flat occiput (HP:0005469)2.13258860
79Vitreoretinal degeneration (HP:0000655)2.11451806
80Abnormality of cochlea (HP:0000375)2.10600285
81Pancreatic islet-cell hyperplasia (HP:0004510)2.10083347
82Broad toe (HP:0001837)2.08253304
83Vaginal fistula (HP:0004320)2.07176755
84Narrow palate (HP:0000189)2.06979112
85Abnormal hand bone ossification (HP:0010660)2.05317985
86Supernumerary bones of the axial skeleton (HP:0009144)2.05284661
87Milia (HP:0001056)2.04812799
88Myokymia (HP:0002411)2.04555275
89Arnold-Chiari malformation (HP:0002308)2.04452737
90Vertebral clefting (HP:0008428)2.04340577
91Widely patent fontanelles and sutures (HP:0004492)2.03814115
92Hypoplasia of the maxilla (HP:0000327)2.02431538
93Duplication of thumb phalanx (HP:0009942)2.00617200
94Patchy hypopigmentation of hair (HP:0011365)1.99784685
95Broad hallux (HP:0010055)1.99405834
96Omphalocele (HP:0001539)1.98887923
97Myelomeningocele (HP:0002475)1.98358067
98Hypoventilation (HP:0002791)1.98354182
99Bone cyst (HP:0012062)1.98264832
100Urethral obstruction (HP:0000796)1.97124497
101Facial cleft (HP:0002006)1.96101779
102Narrow nasal bridge (HP:0000446)1.95209545
103Ankle contracture (HP:0006466)1.94710162
104Preaxial foot polydactyly (HP:0001841)1.93593857
105Atrophic scars (HP:0001075)1.93548257
106Abnormality of the lower motor neuron (HP:0002366)1.93460898
107Late onset (HP:0003584)1.93441562
108Microglossia (HP:0000171)1.93268765
109Optic nerve hypoplasia (HP:0000609)1.92585064
110Bronchomalacia (HP:0002780)1.91756118
111Labial hypoplasia (HP:0000066)1.90449309
112Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90352091
113Esophageal atresia (HP:0002032)1.89838670
114Osteomalacia (HP:0002749)1.89725534
115Median cleft lip (HP:0000161)1.89692291
116Retinal dysplasia (HP:0007973)1.87312873
117Progressive cerebellar ataxia (HP:0002073)1.87271598
118Hemivertebrae (HP:0002937)1.86933509
119Synostosis involving the elbow (HP:0003938)1.85999859
120Humeroradial synostosis (HP:0003041)1.85999859
121Pterygium (HP:0001059)1.85765418
122Intestinal polyposis (HP:0200008)1.85607230
123Xerostomia (HP:0000217)1.85265634
124Abnormality of molar morphology (HP:0011070)1.85194687
125Abnormality of molar (HP:0011077)1.85194687
126Abnormality of the salivary glands (HP:0010286)1.84885833
127Abnormality of the sella turcica (HP:0002679)1.84826358
128Intestinal polyp (HP:0005266)1.84671406
129Protrusio acetabuli (HP:0003179)1.82235121
130Coronal craniosynostosis (HP:0004440)1.81347037
131Absent eyelashes (HP:0000561)1.80708248
132Abnormality of permanent molar morphology (HP:0011071)1.79858391
133Abnormality of the dental root (HP:0006486)1.79858391
134Taurodontia (HP:0000679)1.79858391
135Blue irides (HP:0000635)1.79740956
136Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79512100
137Anal stenosis (HP:0002025)1.78907718
138Meningioma (HP:0002858)1.78184709
139Glossoptosis (HP:0000162)1.77944073
140Abnormality of the dental pulp (HP:0006479)1.77679502
141Ventricular tachycardia (HP:0004756)1.76928556
142Hypoplastic ischia (HP:0003175)1.76308438
143Abnormality of the proximal phalanges of the hand (HP:0009834)1.76103091
144Ketoacidosis (HP:0001993)1.74937522
145Broad thumb (HP:0011304)1.73910074
146Renovascular hypertension (HP:0100817)1.73148929
147Cutaneous finger syndactyly (HP:0010554)1.72423555
148Abnormality of the pubic bones (HP:0003172)1.72330083
149Pendular nystagmus (HP:0012043)1.70801862
150Cutaneous syndactyly (HP:0012725)1.70728718
151Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70217007
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69387891
153Male infertility (HP:0003251)1.69191159
154Morphological abnormality of the inner ear (HP:0011390)1.68278623
155Aqueductal stenosis (HP:0002410)1.67723875
156Absent epiphyses (HP:0010577)1.67685724
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67685724
158Abnormality of the ischium (HP:0003174)1.67137565
159Absent septum pellucidum (HP:0001331)1.65249460
160Diplopia (HP:0000651)1.64477090
161Abnormality of binocular vision (HP:0011514)1.64477090
162Proximal tubulopathy (HP:0000114)1.64193575
163Natal tooth (HP:0000695)1.63991144
164Neonatal short-limb short stature (HP:0008921)1.63462121
165Lower limb amyotrophy (HP:0007210)1.62204538
166Abnormality of the middle phalanges of the toes (HP:0010183)1.61953289
167Aplasia/Hypoplasia of the breasts (HP:0010311)1.61799768
168Morphological abnormality of the middle ear (HP:0008609)1.60095473
169Breast aplasia (HP:0100783)1.59446235
170Impulsivity (HP:0100710)1.58746724
171Postural instability (HP:0002172)1.58704325
172Spastic diplegia (HP:0001264)1.56791183
173Abnormal ventriculo-arterial connection (HP:0011563)1.56495880
174Transposition of the great arteries (HP:0001669)1.56495880
175Abnormal connection of the cardiac segments (HP:0011545)1.56495880
176Atresia of the external auditory canal (HP:0000413)1.55667876
177Broad finger (HP:0001500)1.54991948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.63823468
2PLK45.33574772
3PASK3.71601729
4MAPK153.63933467
5FGFR23.60251360
6TESK13.11952218
7PRKD33.07467272
8LATS22.96733419
9MAP3K22.74881932
10LATS12.62575447
11EPHA32.60143571
12HIPK22.59384309
13NLK2.57383555
14BUB12.56466259
15PDGFRA2.55869568
16NTRK12.55113978
17MAP3K92.50244679
18TAOK32.47492324
19CDC72.43373420
20ERN12.23504736
21VRK22.17920125
22FRK2.14545812
23SMG12.14007354
24FLT31.95985901
25ICK1.95308089
26MAP3K101.95171831
27SIK11.88176488
28BRD41.79277307
29WNK41.77128832
30DDR21.73484644
31FER1.71488578
32TYRO31.67248657
33TTK1.57777249
34PIK3CA1.55433483
35PAK41.53324666
36UHMK11.51195940
37NTRK31.50171178
38CDC42BPA1.47329817
39CDK121.47146108
40CDK71.45232760
41MAP3K11.44781831
42MET1.37744691
43PDGFRB1.33478852
44RET1.33038915
45IRAK11.31765847
46EEF2K1.31138146
47PTK21.28945379
48PNCK1.27979115
49FGFR11.27882290
50CAMK1G1.23431836
51NEK21.18697159
52MST1R1.17400852
53TAF11.11914415
54TESK21.11843895
55MAPKAPK51.09977210
56EPHB11.09562516
57AURKA1.07116430
58PRKCH1.05986791
59STK38L1.03102167
60EPHB21.02367038
61MKNK11.01803904
62CHEK21.00668370
63CAMK1D0.99443356
64WNK10.98252744
65PAK30.93409139
66PIK3CG0.90688205
67RIPK10.89596817
68PRKCE0.88752401
69AKT30.88216539
70FGFR40.87043754
71SCYL20.86992825
72STK30.85600155
73CHEK10.84934933
74PRKD20.84388927
75CSNK1G30.79146124
76CDK40.79018198
77EPHA20.78879984
78MTOR0.78235197
79PBK0.76189817
80FGFR30.75397999
81DYRK1B0.73995871
82PLK10.73412104
83KDR0.73409111
84CDK80.72872659
85PRKG20.72762387
86CSNK1A1L0.70591940
87STK380.69695093
88PLK20.69220591
89CDK190.68910671
90CHUK0.67519048
91JAK10.67025874
92WNK30.66953464
93BRSK10.66932636
94PTK60.66306110
95NUAK10.66116268
96SGK20.65395199
97NME10.65325539
98SGK30.64348180
99MARK20.64201887
100GSK3A0.63997029
101JAK20.63615152
102CSNK1G20.63301799
103CDK11A0.62532347
104PRKD10.61834344
105CDK10.58133142
106PLK30.57844422
107CAMKK20.56375776
108LIMK10.55441932
109CDK20.55250845
110SGK2230.54271209
111SGK4940.54271209
112MAP2K20.53101442
113IGF1R0.52010250
114IRAK20.51329877
115TRIB30.50371084
116MARK30.48357986
117PTK2B0.48316499
118RPS6KB20.48175877
119CAMK40.47596620
120CDK150.46150492
121ERBB40.45633355
122CSNK1E0.45190990
123AKT20.44834406
124CAMK2B0.43944079
125DYRK20.43639597
126CDK180.43090866
127JAK30.42246925
128GSK3B0.42060796
129CDK50.41094032
130CDK30.40385385
131BMX0.39029663
132PRKAA10.38374303
133TNK20.37580818
134CDK140.36723005
135MAPK100.36597947
136MAP3K80.36489385
137CAMK2D0.36360667
138PAK20.35749707
139MAP3K40.35295627
140PRKCI0.33830948
141ATR0.33415535
142KSR20.33310892
143CSNK1A10.32748768
144SIK30.32537251
145RPS6KC10.32239046
146RPS6KL10.32239046
147SIK20.30115771
148DYRK1A0.30003627
149DMPK0.29503642
150MYLK0.29072005
151RPS6KA10.28893043
152PRKCG0.28552834
153MAPK140.28005412
154ALK0.27058549
155MAPK10.26463219
156ZAP700.25951323
157MAPK30.23288845
158INSR0.22013355
159SGK10.21362434
160MAP3K30.21225791
161CSNK1G10.20951189
162TEC0.20103703
163BRSK20.20000679
164AKT10.19703683
165CDK90.19598607
166MAP2K40.19374024
167RPS6KA20.19122328
168ITK0.18630109

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.36430329
2Protein export_Homo sapiens_hsa030604.31007016
3Hedgehog signaling pathway_Homo sapiens_hsa043403.14845798
4Basal cell carcinoma_Homo sapiens_hsa052172.86409155
5Insulin secretion_Homo sapiens_hsa049112.84324617
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.82755728
7Type II diabetes mellitus_Homo sapiens_hsa049302.55436648
8Sulfur metabolism_Homo sapiens_hsa009202.27744060
9Nicotine addiction_Homo sapiens_hsa050331.94953826
10mRNA surveillance pathway_Homo sapiens_hsa030151.88324543
11Sulfur relay system_Homo sapiens_hsa041221.75658620
12DNA replication_Homo sapiens_hsa030301.72495673
13RNA transport_Homo sapiens_hsa030131.70053428
14Carbohydrate digestion and absorption_Homo sapiens_hsa049731.69910613
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68436776
16Vibrio cholerae infection_Homo sapiens_hsa051101.64244659
17Cocaine addiction_Homo sapiens_hsa050301.63788417
18Tight junction_Homo sapiens_hsa045301.56275893
19Wnt signaling pathway_Homo sapiens_hsa043101.55474863
20Spliceosome_Homo sapiens_hsa030401.52738809
21Type I diabetes mellitus_Homo sapiens_hsa049401.50544152
22Base excision repair_Homo sapiens_hsa034101.39467374
23Melanoma_Homo sapiens_hsa052181.38404092
24Mismatch repair_Homo sapiens_hsa034301.37475929
25Notch signaling pathway_Homo sapiens_hsa043301.36989675
26Renin-angiotensin system_Homo sapiens_hsa046141.33978022
27Selenocompound metabolism_Homo sapiens_hsa004501.32042001
28Biosynthesis of amino acids_Homo sapiens_hsa012301.30443091
29Cell cycle_Homo sapiens_hsa041101.30300852
30Arginine and proline metabolism_Homo sapiens_hsa003301.24053082
31Prostate cancer_Homo sapiens_hsa052151.22522435
32Amphetamine addiction_Homo sapiens_hsa050311.21652141
33Phenylalanine metabolism_Homo sapiens_hsa003601.21205134
34Folate biosynthesis_Homo sapiens_hsa007901.17962139
35N-Glycan biosynthesis_Homo sapiens_hsa005101.17781782
36Cardiac muscle contraction_Homo sapiens_hsa042601.13762761
37Insulin resistance_Homo sapiens_hsa049311.13676052
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12624972
39Prolactin signaling pathway_Homo sapiens_hsa049171.06981221
40Axon guidance_Homo sapiens_hsa043601.06037943
41Lysosome_Homo sapiens_hsa041421.04839418
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02720647
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.02638471
44Ribosome_Homo sapiens_hsa030101.01148996
45Glucagon signaling pathway_Homo sapiens_hsa049220.99999790
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97779729
47cAMP signaling pathway_Homo sapiens_hsa040240.97556191
48Glutamatergic synapse_Homo sapiens_hsa047240.96255310
49Cholinergic synapse_Homo sapiens_hsa047250.95415661
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93881391
51Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92852608
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92273987
53Olfactory transduction_Homo sapiens_hsa047400.91401882
54Prion diseases_Homo sapiens_hsa050200.90347631
55Circadian rhythm_Homo sapiens_hsa047100.89857435
56Estrogen signaling pathway_Homo sapiens_hsa049150.89432079
57One carbon pool by folate_Homo sapiens_hsa006700.89021606
58Taste transduction_Homo sapiens_hsa047420.89009443
59Thyroid cancer_Homo sapiens_hsa052160.88703251
60Dopaminergic synapse_Homo sapiens_hsa047280.88531673
61Proteasome_Homo sapiens_hsa030500.88466201
62Arginine biosynthesis_Homo sapiens_hsa002200.87732971
63Pathways in cancer_Homo sapiens_hsa052000.87038564
64MicroRNAs in cancer_Homo sapiens_hsa052060.86723925
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85559031
66AMPK signaling pathway_Homo sapiens_hsa041520.85477900
67Adherens junction_Homo sapiens_hsa045200.83751517
68Lysine degradation_Homo sapiens_hsa003100.82120786
69Long-term potentiation_Homo sapiens_hsa047200.81885738
70Nucleotide excision repair_Homo sapiens_hsa034200.80957486
71Thyroid hormone synthesis_Homo sapiens_hsa049180.80211211
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79431100
73Circadian entrainment_Homo sapiens_hsa047130.78423591
74Oocyte meiosis_Homo sapiens_hsa041140.78246847
75ABC transporters_Homo sapiens_hsa020100.78106317
76TGF-beta signaling pathway_Homo sapiens_hsa043500.77808101
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.77589402
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76912184
79RNA polymerase_Homo sapiens_hsa030200.76910999
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.76456840
81Bladder cancer_Homo sapiens_hsa052190.75950947
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75284737
83Insulin signaling pathway_Homo sapiens_hsa049100.75196971
84Dorso-ventral axis formation_Homo sapiens_hsa043200.74673570
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74565683
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74274594
87Renin secretion_Homo sapiens_hsa049240.74169820
88Endometrial cancer_Homo sapiens_hsa052130.72375158
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72055917
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68522380
91Pancreatic secretion_Homo sapiens_hsa049720.66966612
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66766260
93Melanogenesis_Homo sapiens_hsa049160.66309654
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65675031
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65307855
96Colorectal cancer_Homo sapiens_hsa052100.64839755
97Huntingtons disease_Homo sapiens_hsa050160.64159105
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64036538
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63954834
100Protein digestion and absorption_Homo sapiens_hsa049740.63933936
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63848450
102GABAergic synapse_Homo sapiens_hsa047270.63743704
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.62800557
104Synaptic vesicle cycle_Homo sapiens_hsa047210.62679032
105Homologous recombination_Homo sapiens_hsa034400.61526059
106Ras signaling pathway_Homo sapiens_hsa040140.61123110
107ECM-receptor interaction_Homo sapiens_hsa045120.60702579
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60452762
109Glioma_Homo sapiens_hsa052140.58030596
110Gastric acid secretion_Homo sapiens_hsa049710.57654360
111Proteoglycans in cancer_Homo sapiens_hsa052050.57612021
112Tyrosine metabolism_Homo sapiens_hsa003500.57498112
113Calcium signaling pathway_Homo sapiens_hsa040200.57019753
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.56692476
115Sphingolipid metabolism_Homo sapiens_hsa006000.56251369
116Pyrimidine metabolism_Homo sapiens_hsa002400.55526386
117Gap junction_Homo sapiens_hsa045400.55275989
118Small cell lung cancer_Homo sapiens_hsa052220.55218788
119Amoebiasis_Homo sapiens_hsa051460.55209791
120MAPK signaling pathway_Homo sapiens_hsa040100.55150037
121Serotonergic synapse_Homo sapiens_hsa047260.53557221
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53489462
123Ovarian steroidogenesis_Homo sapiens_hsa049130.53422902
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53168412
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51905199
126ErbB signaling pathway_Homo sapiens_hsa040120.51904157
127Purine metabolism_Homo sapiens_hsa002300.51798167
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.50637164
129Dilated cardiomyopathy_Homo sapiens_hsa054140.50401801
130Retinol metabolism_Homo sapiens_hsa008300.49705096
131Focal adhesion_Homo sapiens_hsa045100.49166143
132Regulation of autophagy_Homo sapiens_hsa041400.49074014
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.48937564
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46851256
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46438558
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46043591
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45936708
138Carbon metabolism_Homo sapiens_hsa012000.45347392
139Morphine addiction_Homo sapiens_hsa050320.44799153
140mTOR signaling pathway_Homo sapiens_hsa041500.44718066
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44436141
142Oxytocin signaling pathway_Homo sapiens_hsa049210.43922190
143Hippo signaling pathway_Homo sapiens_hsa043900.43725898
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.43233693
145Vitamin digestion and absorption_Homo sapiens_hsa049770.42384813
146Rap1 signaling pathway_Homo sapiens_hsa040150.41748350
147FoxO signaling pathway_Homo sapiens_hsa040680.40653112
148Starch and sucrose metabolism_Homo sapiens_hsa005000.38518344
149Chronic myeloid leukemia_Homo sapiens_hsa052200.38219165
150Galactose metabolism_Homo sapiens_hsa000520.35774614
151Alcoholism_Homo sapiens_hsa050340.33924526
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33535644
153Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33037802
154GnRH signaling pathway_Homo sapiens_hsa049120.32979407
155Renal cell carcinoma_Homo sapiens_hsa052110.31690433
156Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31038718

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