RSPH9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein thought to be a component of the radial spoke head in motile cilia and flagella. Mutations in this gene are associated with primary ciliary dyskinesia 12. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cilium movement (GO:0003341)7.53473221
2axonemal dynein complex assembly (GO:0070286)7.13740435
3epithelial cilium movement (GO:0003351)6.63107461
4cilium or flagellum-dependent cell motility (GO:0001539)6.50327555
5* axoneme assembly (GO:0035082)6.24800375
6GTP biosynthetic process (GO:0006183)5.40751647
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.33897883
8intraciliary transport (GO:0042073)5.29188498
9protein localization to cilium (GO:0061512)5.22952806
10motile cilium assembly (GO:0044458)5.10291107
11nucleoside diphosphate phosphorylation (GO:0006165)4.69114104
12negative regulation of T cell differentiation in thymus (GO:0033085)4.68733864
13ventricular system development (GO:0021591)4.67325972
14regulation of cilium movement (GO:0003352)4.48201581
15UTP biosynthetic process (GO:0006228)4.43741997
16neuron cell-cell adhesion (GO:0007158)4.32901867
17microtubule depolymerization (GO:0007019)4.08345153
18centriole assembly (GO:0098534)4.03315155
19cilium organization (GO:0044782)4.00057787
20cilium assembly (GO:0042384)3.98362652
21primary alcohol catabolic process (GO:0034310)3.97687874
22cilium morphogenesis (GO:0060271)3.90176340
23response to xenobiotic stimulus (GO:0009410)3.88164995
24UTP metabolic process (GO:0046051)3.86308130
25sensory perception of smell (GO:0007608)3.80241873
26guanosine-containing compound biosynthetic process (GO:1901070)3.80193373
27protein neddylation (GO:0045116)3.79037531
28behavioral response to nicotine (GO:0035095)3.72761575
29presynaptic membrane assembly (GO:0097105)3.65853607
30CTP metabolic process (GO:0046036)3.56842061
31CTP biosynthetic process (GO:0006241)3.56842061
32sperm motility (GO:0030317)3.56019983
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55459663
34left/right axis specification (GO:0070986)3.47160522
35centriole replication (GO:0007099)3.44004093
36glutathione derivative biosynthetic process (GO:1901687)3.40022612
37glutathione derivative metabolic process (GO:1901685)3.40022612
38water-soluble vitamin biosynthetic process (GO:0042364)3.39747102
39aldehyde catabolic process (GO:0046185)3.35641061
40protein complex biogenesis (GO:0070271)3.34756559
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31230923
42determination of left/right symmetry (GO:0007368)3.27965076
43detection of calcium ion (GO:0005513)3.26079585
44presynaptic membrane organization (GO:0097090)3.24891799
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.24348124
46positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.20133218
47vocalization behavior (GO:0071625)3.19558112
48acrosome reaction (GO:0007340)3.19000960
49photoreceptor cell maintenance (GO:0045494)3.17630637
50female mating behavior (GO:0060180)3.14624206
51postsynaptic membrane organization (GO:0001941)3.13537620
52microtubule polymerization or depolymerization (GO:0031109)3.13315757
53ATP synthesis coupled proton transport (GO:0015986)3.12902413
54energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12902413
55smoothened signaling pathway (GO:0007224)3.12513653
56* cellular component assembly involved in morphogenesis (GO:0010927)3.08771676
57protein localization to synapse (GO:0035418)3.07257344
58determination of bilateral symmetry (GO:0009855)3.05339731
59mitochondrial respiratory chain complex assembly (GO:0033108)3.00235755
60specification of symmetry (GO:0009799)3.00212748
61neuron recognition (GO:0008038)2.99866758
62nonmotile primary cilium assembly (GO:0035058)2.98591202
63pyrimidine-containing compound transmembrane transport (GO:0072531)2.98427128
64pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.97962290
65sequestering of actin monomers (GO:0042989)2.96501959
66purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.93350819
67response to histamine (GO:0034776)2.91491916
68regulation of microtubule-based movement (GO:0060632)2.91136449
69negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91068885
70vitamin transmembrane transport (GO:0035461)2.89693809
71glutamate receptor signaling pathway (GO:0007215)2.89465800
72negative regulation of inclusion body assembly (GO:0090084)2.89450590
73ionotropic glutamate receptor signaling pathway (GO:0035235)2.88772983
74regulation of glutamate secretion (GO:0014048)2.87713094
75mitochondrial respiratory chain complex I assembly (GO:0032981)2.87529469
76NADH dehydrogenase complex assembly (GO:0010257)2.87529469
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87529469
78transmission of nerve impulse (GO:0019226)2.87310059
79retinal rod cell development (GO:0046548)2.84904624
80regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.84234575
81regulation of inclusion body assembly (GO:0090083)2.83171958
82dopamine biosynthetic process (GO:0042416)2.82124494
83cornea development in camera-type eye (GO:0061303)2.82084375
84sperm capacitation (GO:0048240)2.81347300
85purine nucleoside triphosphate biosynthetic process (GO:0009145)2.81248450
86* microtubule bundle formation (GO:0001578)2.81045753
87protein polyglutamylation (GO:0018095)2.80754581
88regulation of vesicle fusion (GO:0031338)2.80181374
89retinoic acid metabolic process (GO:0042573)2.80079932
90ethanol metabolic process (GO:0006067)2.78438361
91diterpenoid biosynthetic process (GO:0016102)2.77944088
92electron transport chain (GO:0022900)2.76084391
93pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75372405
94energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.75159996
95ATP hydrolysis coupled proton transport (GO:0015991)2.75159996
96regulation of catecholamine metabolic process (GO:0042069)2.74048952
97regulation of dopamine metabolic process (GO:0042053)2.74048952
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.73570709
99respiratory electron transport chain (GO:0022904)2.73309698
100regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.73009621
101negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.72965590
102microtubule severing (GO:0051013)2.71800739
103axonal fasciculation (GO:0007413)2.70422911
104neurotransmitter uptake (GO:0001504)2.70309045
105sensory perception of chemical stimulus (GO:0007606)2.69169962
106platelet dense granule organization (GO:0060155)2.68578765
107positive regulation of synapse assembly (GO:0051965)2.67668148
108calcium ion-dependent exocytosis (GO:0017156)2.67627846
109long-term synaptic potentiation (GO:0060291)2.67408457
110terpenoid biosynthetic process (GO:0016114)2.64545324
111establishment of planar polarity (GO:0001736)2.64142679
112establishment of tissue polarity (GO:0007164)2.64142679
113pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.63998121
114one-carbon compound transport (GO:0019755)2.63645676
115cytoplasmic microtubule organization (GO:0031122)2.63390964
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.62379074
117axon ensheathment in central nervous system (GO:0032291)2.62055328
118central nervous system myelination (GO:0022010)2.62055328
119spinal cord motor neuron differentiation (GO:0021522)2.61311285
120neuron fate determination (GO:0048664)2.61215281
121regulation of autophagic vacuole assembly (GO:2000785)2.60650883
122left/right pattern formation (GO:0060972)2.60412657
123gamma-aminobutyric acid signaling pathway (GO:0007214)2.59073829
124base-excision repair, AP site formation (GO:0006285)2.58973667
125regulation of protein kinase A signaling (GO:0010738)2.58585845
126regulation of inositol phosphate biosynthetic process (GO:0010919)2.58148182
127retinal cone cell development (GO:0046549)2.57891306
128nucleotide transmembrane transport (GO:1901679)2.55989039
129spermatid development (GO:0007286)2.55317312
130* microtubule-based movement (GO:0007018)2.54598180
131calcium-mediated signaling using intracellular calcium source (GO:0035584)2.54451816
132synaptic transmission, glutamatergic (GO:0035249)2.54413084
133startle response (GO:0001964)2.53998478
134regulation of respiratory gaseous exchange (GO:0043576)2.53616352
135neuron-neuron synaptic transmission (GO:0007270)2.52227966
136G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51082923
137regulation of glutamate receptor signaling pathway (GO:1900449)2.50900287
138synaptic vesicle exocytosis (GO:0016079)2.49805215
139tolerance induction (GO:0002507)2.48584712
140pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.47738386
141regulation of interleukin-5 production (GO:0032674)2.47060505
142* cell projection assembly (GO:0030031)2.46503188
143regulation of female receptivity (GO:0045924)2.45891190
144ribonucleoside triphosphate biosynthetic process (GO:0009201)2.45254095
145adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.42764092
146nucleotide phosphorylation (GO:0046939)2.41193860
147pyrimidine nucleobase catabolic process (GO:0006208)2.40888030
148dopamine transport (GO:0015872)2.40312033
149exogenous drug catabolic process (GO:0042738)2.40287832
150pyrimidine nucleotide catabolic process (GO:0006244)2.38963411
151chaperone-mediated protein transport (GO:0072321)2.37404408
152positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.37179862
153phenol-containing compound catabolic process (GO:0019336)2.36680039
154retinol metabolic process (GO:0042572)2.36594688
155organelle assembly (GO:0070925)2.36211635
156intra-S DNA damage checkpoint (GO:0031573)2.33189299
157negative regulation of heart rate (GO:0010459)2.32840633
158negative regulation of response to food (GO:0032096)2.30976734
159negative regulation of appetite (GO:0032099)2.30976734
160lateral ventricle development (GO:0021670)2.30234642
161respiratory chain complex IV assembly (GO:0008535)2.28919835
162GPI anchor metabolic process (GO:0006505)2.28188152
163cytochrome complex assembly (GO:0017004)2.27852059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.43832749
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.66106029
3GBX2_23144817_ChIP-Seq_PC3_Human3.29857253
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.87529290
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59584996
6TAF15_26573619_Chip-Seq_HEK293_Human2.59555657
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.35251160
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35196656
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35010258
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26703318
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25805960
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23871379
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20269034
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18705391
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17710148
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17686470
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17617786
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12723400
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.11171373
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09669918
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09237631
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.08636915
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08514127
24VDR_22108803_ChIP-Seq_LS180_Human2.07863148
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.04389299
26EWS_26573619_Chip-Seq_HEK293_Human1.97434485
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96996543
28REST_21632747_ChIP-Seq_MESCs_Mouse1.95382423
29* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94097423
30P300_19829295_ChIP-Seq_ESCs_Human1.93286810
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89421390
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89108333
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.86051069
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85421057
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.83320727
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82372620
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82372620
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80529240
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80510788
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79520031
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78826873
42RNF2_27304074_Chip-Seq_NSC_Mouse1.76211940
43SMAD4_21799915_ChIP-Seq_A2780_Human1.72924211
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68269389
45FUS_26573619_Chip-Seq_HEK293_Human1.64729279
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.62417913
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.61262910
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53780282
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.51433213
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50627155
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47968839
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47010132
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46837348
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.46837348
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.46475532
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46290714
57ZNF274_21170338_ChIP-Seq_K562_Hela1.43146666
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42579557
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41256540
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40952798
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40220208
62DROSHA_22980978_ChIP-Seq_HELA_Human1.38440400
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37984302
64ER_23166858_ChIP-Seq_MCF-7_Human1.37042694
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36302165
66AR_20517297_ChIP-Seq_VCAP_Human1.35833437
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35741672
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.34574446
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33609527
70MYC_18940864_ChIP-ChIP_HL60_Human1.32265154
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31755791
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.31231430
73* NCOR_22424771_ChIP-Seq_293T_Human1.30853522
74SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30450652
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29939633
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28801072
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.28751225
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.27686151
79RBPJ_21746931_ChIP-Seq_IB4_Human1.27383454
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26367164
81AR_25329375_ChIP-Seq_VCAP_Human1.25929491
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25090914
83PHF8_20622853_ChIP-Seq_HELA_Human1.24843464
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23459460
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23459460
86VDR_23849224_ChIP-Seq_CD4+_Human1.21576713
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20695845
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20642221
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20574916
90IGF1R_20145208_ChIP-Seq_DFB_Human1.20105414
91SOX2_19829295_ChIP-Seq_ESCs_Human1.19911878
92NANOG_19829295_ChIP-Seq_ESCs_Human1.19911878
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.19895580
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19337337
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17808905
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17737539
97* MYC_19829295_ChIP-Seq_ESCs_Human1.17702528
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17608768
99RUNX2_22187159_ChIP-Seq_PCA_Human1.17549225
100AR_21572438_ChIP-Seq_LNCaP_Human1.17279140
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17262589
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16651615
103ETV1_20927104_ChIP-Seq_GIST48_Human1.15526665
104CBP_20019798_ChIP-Seq_JUKART_Human1.14306353
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14306353
106TP53_18474530_ChIP-ChIP_U2OS_Human1.14259045
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13969940
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13367660
109P53_22387025_ChIP-Seq_ESCs_Mouse1.12928923
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12099741
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11879731
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11236245
113STAT3_23295773_ChIP-Seq_U87_Human1.11083621
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10530851
115CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.10352338
116SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10003288
117TP53_22573176_ChIP-Seq_HFKS_Human1.09992618
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09947166
119GATA3_21878914_ChIP-Seq_MCF-7_Human1.09565450
120TCF4_22108803_ChIP-Seq_LS180_Human1.09557952
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08340832
122PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08044816
123GATA6_21074721_ChIP-Seq_CACO-2_Human1.07492108
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.07271060
125SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06792023
126NANOG_20526341_ChIP-Seq_ESCs_Human1.06739401
127HNFA_21074721_ChIP-Seq_CACO-2_Human1.06558261
128ARNT_22903824_ChIP-Seq_MCF-7_Human1.06156938
129EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05962715
130JUN_21703547_ChIP-Seq_K562_Human1.05829032
131KDM2B_26808549_Chip-Seq_REH_Human1.05664489
132YY1_22570637_ChIP-Seq_MALME-3M_Human1.05487285
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.05203940
134TCF4_23295773_ChIP-Seq_U87_Human1.05111708
135BCAT_22108803_ChIP-Seq_LS180_Human1.05057548
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04703573
137STAT3_18555785_Chip-Seq_ESCs_Mouse1.04536947
138NFYB_21822215_ChIP-Seq_K562_Human1.04460602
139SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03875337
140CMYC_18555785_Chip-Seq_ESCs_Mouse1.03807722
141NFYA_21822215_ChIP-Seq_K562_Human1.03476438
142SRF_21415370_ChIP-Seq_HL-1_Mouse1.03221445
143NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01823330
144EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01796880
145SOX2_18555785_Chip-Seq_ESCs_Mouse1.01240721
146STAT1_20625510_ChIP-Seq_HELA_Human1.01169198
147RING1B_27294783_Chip-Seq_ESCs_Mouse1.01078337
148PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00522847
149CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00192694
150ERG_20517297_ChIP-Seq_VCAP_Human0.99586276
151SMAD4_21741376_ChIP-Seq_EPCs_Human0.99497383
152ELK1_19687146_ChIP-ChIP_HELA_Human0.95975205
153TBL1_22424771_ChIP-Seq_293T_Human0.95960258
154ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93587699
155KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93213577
156ETS1_20019798_ChIP-Seq_JURKAT_Human0.92982441
157NFE2_27457419_Chip-Seq_LIVER_Mouse0.92655564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.82693963
2MP0001984_abnormal_olfaction3.69155705
3MP0008875_abnormal_xenobiotic_pharmacok3.24293665
4MP0005645_abnormal_hypothalamus_physiol2.81671678
5MP0005410_abnormal_fertilization2.70323515
6MP0005646_abnormal_pituitary_gland2.62353137
7MP0003635_abnormal_synaptic_transmissio2.58160792
8MP0004859_abnormal_synaptic_plasticity2.50991431
9MP0009745_abnormal_behavioral_response2.49728444
10MP0006276_abnormal_autonomic_nervous2.35338144
11MP0002572_abnormal_emotion/affect_behav2.34856012
12MP0001905_abnormal_dopamine_level2.33179690
13MP0001968_abnormal_touch/_nociception2.32207876
14MP0002736_abnormal_nociception_after2.29389639
15MP0001529_abnormal_vocalization2.28783892
16MP0002063_abnormal_learning/memory/cond2.28400465
17MP0001501_abnormal_sleep_pattern2.28234632
18MP0002277_abnormal_respiratory_mucosa2.27695587
19MP0003136_yellow_coat_color2.26554994
20MP0001440_abnormal_grooming_behavior2.26121308
21MP0004270_analgesia2.22322889
22MP0002064_seizures2.16328824
23MP0002734_abnormal_mechanical_nocicepti2.14054345
24MP0005423_abnormal_somatic_nervous2.11247157
25MP0001486_abnormal_startle_reflex2.10676517
26MP0006292_abnormal_olfactory_placode2.07025631
27MP0009046_muscle_twitch2.03024434
28MP0002272_abnormal_nervous_system2.02171934
29MP0003122_maternal_imprinting1.96701408
30MP0002638_abnormal_pupillary_reflex1.93601236
31MP0002132_abnormal_respiratory_system1.91739495
32MP0000778_abnormal_nervous_system1.89834491
33MP0000566_synostosis1.87089247
34MP0002557_abnormal_social/conspecific_i1.84882255
35MP0002735_abnormal_chemical_nociception1.82079718
36MP0001188_hyperpigmentation1.78079128
37MP0001502_abnormal_circadian_rhythm1.77792361
38MP0002067_abnormal_sensory_capabilities1.69738374
39MP0002184_abnormal_innervation1.61551921
40MP0004742_abnormal_vestibular_system1.55701831
41MP0005379_endocrine/exocrine_gland_phen1.53196727
42MP0004019_abnormal_vitamin_homeostasis1.53143897
43MP0002653_abnormal_ependyma_morphology1.52842656
44MP0001970_abnormal_pain_threshold1.52720223
45MP0001293_anophthalmia1.52640090
46MP0010386_abnormal_urinary_bladder1.48822118
47MP0005084_abnormal_gallbladder_morpholo1.48713307
48MP0002876_abnormal_thyroid_physiology1.47626380
49MP0005394_taste/olfaction_phenotype1.46435023
50MP0005499_abnormal_olfactory_system1.46435023
51MP0000631_abnormal_neuroendocrine_gland1.44529540
52MP0008789_abnormal_olfactory_epithelium1.43815574
53MP0005551_abnormal_eye_electrophysiolog1.38554684
54MP0005083_abnormal_biliary_tract1.37498903
55MP0002733_abnormal_thermal_nociception1.36805707
56MP0003011_delayed_dark_adaptation1.34135060
57MP0008872_abnormal_physiological_respon1.31851049
58MP0003718_maternal_effect1.29102295
59MP0001485_abnormal_pinna_reflex1.28906817
60MP0005386_behavior/neurological_phenoty1.28461831
61MP0004924_abnormal_behavior1.28461831
62MP0006072_abnormal_retinal_apoptosis1.25277039
63MP0006036_abnormal_mitochondrial_physio1.23996957
64MP0004142_abnormal_muscle_tone1.22528543
65MP0002882_abnormal_neuron_morphology1.21323538
66MP0002233_abnormal_nose_morphology1.21212191
67MP0000026_abnormal_inner_ear1.21178296
68MP0001986_abnormal_taste_sensitivity1.20292511
69MP0009780_abnormal_chondrocyte_physiolo1.20203567
70MP0005377_hearing/vestibular/ear_phenot1.19076382
71MP0003878_abnormal_ear_physiology1.19076382
72MP0003186_abnormal_redox_activity1.18808882
73MP0001963_abnormal_hearing_physiology1.17798123
74MP0003698_abnormal_male_reproductive1.17625619
75MP0010030_abnormal_orbit_morphology1.16264423
76MP0003329_amyloid_beta_deposits1.15392374
77MP0005409_darkened_coat_color1.14886144
78MP0002938_white_spotting1.14462564
79MP0008004_abnormal_stomach_pH1.13822970
80MP0001324_abnormal_eye_pigmentation1.13551779
81MP0000383_abnormal_hair_follicle1.13134743
82MP0005389_reproductive_system_phenotype1.09478948
83MP0002752_abnormal_somatic_nervous1.07446601
84MP0004885_abnormal_endolymph1.07194798
85MP0004133_heterotaxia1.05870569
86MP0000049_abnormal_middle_ear1.04421123
87MP0005174_abnormal_tail_pigmentation1.03026797
88MP0004858_abnormal_nervous_system1.02204110
89MP0002152_abnormal_brain_morphology1.00348396
90MP0001765_abnormal_ion_homeostasis1.00130693
91MP0003283_abnormal_digestive_organ0.99926400
92MP0003787_abnormal_imprinting0.99894511
93MP0002066_abnormal_motor_capabilities/c0.99511932
94MP0003634_abnormal_glial_cell0.98483151
95MP0002282_abnormal_trachea_morphology0.97726597
96MP0002163_abnormal_gland_morphology0.97212107
97MP0000955_abnormal_spinal_cord0.96960711
98MP0002822_catalepsy0.94763621
99MP0003806_abnormal_nucleotide_metabolis0.92468161
100MP0005253_abnormal_eye_physiology0.91937632
101MP0002229_neurodegeneration0.91356325
102MP0002160_abnormal_reproductive_system0.91161343
103MP0008569_lethality_at_weaning0.91021411
104MP0005195_abnormal_posterior_eye0.90766423
105MP0002909_abnormal_adrenal_gland0.89853492
106MP0001664_abnormal_digestion0.88845440
107MP0003879_abnormal_hair_cell0.88255245
108MP0005636_abnormal_mineral_homeostasis0.87997086
109MP0009379_abnormal_foot_pigmentation0.87054175
110MP0000013_abnormal_adipose_tissue0.86737907
111MP0003937_abnormal_limbs/digits/tail_de0.86094625
112MP0004043_abnormal_pH_regulation0.85562908
113MP0008877_abnormal_DNA_methylation0.84789303
114MP0003633_abnormal_nervous_system0.83956239
115MP0004811_abnormal_neuron_physiology0.83354802
116MP0005171_absent_coat_pigmentation0.82452845
117MP0002102_abnormal_ear_morphology0.82203845
118MP0003690_abnormal_glial_cell0.80345040
119MP0001756_abnormal_urination0.80321741
120MP0002837_dystrophic_cardiac_calcinosis0.80150120
121MP0000538_abnormal_urinary_bladder0.79926797
122MP0003938_abnormal_ear_development0.79553577
123MP0002928_abnormal_bile_duct0.79031717
124MP0005395_other_phenotype0.78324632
125MP0005464_abnormal_platelet_physiology0.77651424
126MP0008995_early_reproductive_senescence0.75333899
127MP0001929_abnormal_gametogenesis0.75015542
128MP0002069_abnormal_eating/drinking_beha0.74806568
129MP0003631_nervous_system_phenotype0.74662276
130MP0000372_irregular_coat_pigmentation0.74349594
131MP0003890_abnormal_embryonic-extraembry0.72824316
132MP0005391_vision/eye_phenotype0.70670907
133MP0001944_abnormal_pancreas_morphology0.68708237
134MP0008058_abnormal_DNA_repair0.67391933
135MP0005332_abnormal_amino_acid0.66575453

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.44897114
2* Abnormal ciliary motility (HP:0012262)8.12433918
3* Abnormal respiratory motile cilium physiology (HP:0012261)8.05671150
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.80484310
5Absent/shortened dynein arms (HP:0200106)6.80484310
6* Abnormal respiratory epithelium morphology (HP:0012253)6.60090187
7* Abnormal respiratory motile cilium morphology (HP:0005938)6.60090187
8* Rhinitis (HP:0012384)6.34731987
9Chronic bronchitis (HP:0004469)4.39176858
10Medial flaring of the eyebrow (HP:0010747)4.23535490
11Gait imbalance (HP:0002141)4.07754608
12True hermaphroditism (HP:0010459)4.01641556
13Congenital primary aphakia (HP:0007707)3.90866776
14Pancreatic fibrosis (HP:0100732)3.72451975
15Molar tooth sign on MRI (HP:0002419)3.72274815
16Abnormality of midbrain morphology (HP:0002418)3.72274815
17Nephrogenic diabetes insipidus (HP:0009806)3.62578741
18Nephronophthisis (HP:0000090)3.55145463
19Focal motor seizures (HP:0011153)3.35964806
20* Bronchiectasis (HP:0002110)3.35795323
21Tubulointerstitial nephritis (HP:0001970)3.17568885
22Genital tract atresia (HP:0001827)3.05503559
23Vaginal atresia (HP:0000148)3.01736692
24Infertility (HP:0000789)2.83916865
25Abnormality of the renal medulla (HP:0100957)2.81032750
26Median cleft lip (HP:0000161)2.80819496
27Poor coordination (HP:0002370)2.75798843
28Aplasia/Hypoplasia of the lens (HP:0008063)2.71084680
29Acute necrotizing encephalopathy (HP:0006965)2.70582371
30Pancreatic cysts (HP:0001737)2.69947410
31Tubular atrophy (HP:0000092)2.69640341
32Occipital encephalocele (HP:0002085)2.66213823
33Hyperventilation (HP:0002883)2.59910524
34Chronic hepatic failure (HP:0100626)2.58282432
35Recurrent otitis media (HP:0000403)2.56684917
36Male infertility (HP:0003251)2.54583262
37Retinal dysplasia (HP:0007973)2.52454257
38Atonic seizures (HP:0010819)2.43951224
39Hyperactive renin-angiotensin system (HP:0000841)2.43307373
40Progressive macrocephaly (HP:0004481)2.40743227
41Hypothermia (HP:0002045)2.38674524
42Postaxial hand polydactyly (HP:0001162)2.36572184
43Abnormal mitochondria in muscle tissue (HP:0008316)2.33879678
443-Methylglutaconic aciduria (HP:0003535)2.32131225
45Limb dystonia (HP:0002451)2.31376435
46Nasal polyposis (HP:0100582)2.30717423
47Postaxial foot polydactyly (HP:0001830)2.25078115
48Recurrent sinusitis (HP:0011108)2.24651008
49Epileptic encephalopathy (HP:0200134)2.23302100
50Visual hallucinations (HP:0002367)2.21409576
51Increased hepatocellular lipid droplets (HP:0006565)2.20884020
52Mitochondrial inheritance (HP:0001427)2.20796291
53Abnormal hair whorl (HP:0010721)2.20491927
54Congenital hepatic fibrosis (HP:0002612)2.20066611
55Furrowed tongue (HP:0000221)2.20063108
56Chronic otitis media (HP:0000389)2.19315533
57Cystic liver disease (HP:0006706)2.18808884
58Abnormality of dentin (HP:0010299)2.16231517
59Neurofibrillary tangles (HP:0002185)2.13807207
60Aplasia/Hypoplasia of the spleen (HP:0010451)2.13410903
61Asplenia (HP:0001746)2.12979023
62Abnormality of the renal cortex (HP:0011035)2.12744455
63Focal seizures (HP:0007359)2.12530575
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.11840206
65Bifid tongue (HP:0010297)2.10219036
66Male pseudohermaphroditism (HP:0000037)2.08337641
67Febrile seizures (HP:0002373)2.08320342
68Sclerocornea (HP:0000647)2.06799045
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05520099
70Lipid accumulation in hepatocytes (HP:0006561)2.03661972
71Abnormality of permanent molar morphology (HP:0011071)2.01951144
72Abnormality of the dental root (HP:0006486)2.01951144
73Taurodontia (HP:0000679)2.01951144
74Optic disc pallor (HP:0000543)2.00154961
75Polyphagia (HP:0002591)1.98963806
76Abnormality of the dental pulp (HP:0006479)1.96710665
77Specific learning disability (HP:0001328)1.95062280
78Preaxial hand polydactyly (HP:0001177)1.94546602
79Absence seizures (HP:0002121)1.93300095
80Abnormality of molar morphology (HP:0011070)1.93098278
81Abnormality of molar (HP:0011077)1.93098278
82Acute encephalopathy (HP:0006846)1.88570784
83Oculomotor apraxia (HP:0000657)1.88021226
84Bronchitis (HP:0012387)1.87270322
85Abnormality of renal resorption (HP:0011038)1.86330904
86Renal salt wasting (HP:0000127)1.85154218
87Tubulointerstitial abnormality (HP:0001969)1.84599695
88Cerebral inclusion bodies (HP:0100314)1.82559423
89Dialeptic seizures (HP:0011146)1.79266423
90Atelectasis (HP:0100750)1.79006179
91Increased intramyocellular lipid droplets (HP:0012240)1.78663927
92Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76654850
93Decreased circulating renin level (HP:0003351)1.76541315
94Generalized tonic-clonic seizures (HP:0002069)1.76480476
95Hemiparesis (HP:0001269)1.76297983
96Stage 5 chronic kidney disease (HP:0003774)1.76028191
97Retinitis pigmentosa (HP:0000510)1.73825127
98Nephropathy (HP:0000112)1.72838745
99Aganglionic megacolon (HP:0002251)1.72758581
100Myokymia (HP:0002411)1.71443708
101Broad foot (HP:0001769)1.70868883
102Polyuria (HP:0000103)1.70543673
103Anencephaly (HP:0002323)1.69825795
104Bile duct proliferation (HP:0001408)1.68947818
105Abnormal biliary tract physiology (HP:0012439)1.68947818
106Abnormal drinking behavior (HP:0030082)1.67761968
107Polydipsia (HP:0001959)1.67761968
108Progressive cerebellar ataxia (HP:0002073)1.67685556
109Abnormality of the nasal mucosa (HP:0000433)1.67558311
110Supernumerary spleens (HP:0009799)1.66381862
111Decreased activity of mitochondrial respiratory chain (HP:0008972)1.64849247
112Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.64849247
113Abnormal rod and cone electroretinograms (HP:0008323)1.64837405
114Fibular hypoplasia (HP:0003038)1.63617037
115Increased CSF lactate (HP:0002490)1.63485239
116Renal Fanconi syndrome (HP:0001994)1.61345843
117Amblyopia (HP:0000646)1.60841670
118Supranuclear gaze palsy (HP:0000605)1.59933360
119Broad-based gait (HP:0002136)1.59775611
120Methylmalonic acidemia (HP:0002912)1.58164246
121* Chronic sinusitis (HP:0011109)1.57903886
122Decreased central vision (HP:0007663)1.56281713
123Abnormality of macular pigmentation (HP:0008002)1.54906899
124Hypokalemic alkalosis (HP:0001949)1.53841342
125Exertional dyspnea (HP:0002875)1.52904673
126Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.52486020
127Increased muscle lipid content (HP:0009058)1.51246928
128Asthma (HP:0002099)1.50763546
129Hyperaldosteronism (HP:0000859)1.50533210
130Aplasia involving bones of the upper limbs (HP:0009823)1.49243024
131Aplasia of the phalanges of the hand (HP:0009802)1.49243024
132Aplasia involving bones of the extremities (HP:0009825)1.49243024
133Optic nerve coloboma (HP:0000588)1.49042233
134Abnormality of renin-angiotensin system (HP:0000847)1.48644467
135Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.48077332
136Abolished electroretinogram (ERG) (HP:0000550)1.43245370
137Narrow forehead (HP:0000341)1.42694860
138Abnormal number of erythroid precursors (HP:0012131)1.42590090
139Bony spicule pigmentary retinopathy (HP:0007737)1.41804696

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.91212414
2MAPK153.43191794
3TLK13.43182218
4PNCK3.30290308
5EPHA42.76531316
6NTRK32.75510546
7NTRK22.55111034
8MAP3K122.33631283
9TNIK2.30831082
10MAP4K22.29892977
11MAP2K72.29454197
12EIF2AK12.09466394
13ARAF2.06373040
14MARK11.94003639
15BUB11.91107963
16MAP3K41.86918736
17BMPR1B1.84774586
18GRK71.77051373
19PLK21.72110617
20MAPK131.71680021
21TRIM281.65161479
22BMPR21.54990487
23ADRBK21.54940156
24STK161.54471650
25GRK51.54323295
26PHKG21.53843865
27PHKG11.53843865
28STK391.47601320
29MINK11.43043808
30EPHA21.37722923
31WNK41.37100161
32OXSR11.36109434
33NME11.35229482
34NUAK11.26977743
35ERBB31.26438918
36TAOK31.25733654
37PTK2B1.25369416
38SIK31.22841345
39EPHA31.22097383
40MUSK1.21695464
41CAMK2B1.20907050
42CAMK2A1.20093385
43MKNK21.19966633
44AKT31.19952790
45PRKCG1.17720937
46IRAK21.16207199
47BCR1.13038076
48PDK41.11876482
49PDK31.11876482
50MST41.10414921
51IRAK11.09180116
52NEK61.08366999
53BCKDK1.07961036
54SGK2231.07659707
55SGK4941.07659707
56ZAK1.07460743
57DYRK31.06361572
58FGR1.02312611
59MAPKAPK31.00873033
60INSRR0.99558986
61SGK20.98382264
62WNK30.97252171
63CDK30.96544941
64DYRK1A0.94429442
65PRKCE0.92063963
66STK240.90204962
67PAK30.89787354
68RIPK40.88605046
69MYLK0.87735319
70MAPKAPK50.86459742
71CAMK2D0.84425057
72MAP2K40.83700684
73CDK50.83238065
74DAPK20.82741721
75PRPF4B0.80704187
76MAP2K60.79977363
77ADRBK10.79957062
78FRK0.79858737
79PASK0.79577037
80BRAF0.76712466
81CDK190.76390306
82MAP3K90.73643146
83WEE10.73554198
84CSNK1G20.72218431
85NEK90.71377504
86CAMKK20.71344125
87GRK10.70263522
88DAPK10.69936119
89CAMK2G0.69902787
90ERBB20.68673054
91UHMK10.68642866
92MAP2K20.68287644
93CSNK1G30.66925721
94PDK20.65514500
95PRKCI0.64051358
96FGFR20.63788221
97PLK10.62553352
98NLK0.60695444
99TAOK10.59914906
100STK30.59169487
101TEC0.58752599
102AURKA0.58156266
103DYRK20.58054494
104PRKACA0.57509469
105VRK10.57467927
106PLK30.56520422
107TNK20.54949982
108PRKG10.54631424
109YES10.53742147
110TTK0.53625074
111HIPK20.52515891
112ROCK20.52005261
113ACVR1B0.51848672
114TIE10.51379326
115CSNK1G10.48867667
116RPS6KA50.48300270
117FES0.48176840
118TSSK60.47668375
119PKN10.47187738
120MARK30.47132404
121TXK0.46949491
122SIK20.46288575
123CSK0.43983385
124NEK10.43959920
125GRK60.43821711
126PRKD30.43315027
127PINK10.42853032
128LMTK20.42073482
129CAMK1G0.40999227
130CDK180.40759515
131CDK140.40673764
132PRKCQ0.38841095
133MKNK10.37673948
134STK38L0.37248902
135EPHB10.36772160
136NTRK10.36532043
137PRKCA0.36332877
138CSNK1A1L0.35965241
139EPHB20.35943033
140RPS6KA20.35919335
141PRKCZ0.35743252
142TGFBR10.35621076
143PIM20.34497752
144PLK40.34373385
145CSNK1A10.30924299
146STK110.30153540

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.65473283
2Nicotine addiction_Homo sapiens_hsa050333.53972771
3Olfactory transduction_Homo sapiens_hsa047403.11172172
4Ribosome_Homo sapiens_hsa030103.01828266
5Collecting duct acid secretion_Homo sapiens_hsa049662.79087486
6Parkinsons disease_Homo sapiens_hsa050122.77381609
7Chemical carcinogenesis_Homo sapiens_hsa052042.62876999
8Huntingtons disease_Homo sapiens_hsa050162.56587810
9Alzheimers disease_Homo sapiens_hsa050102.53405952
10Taste transduction_Homo sapiens_hsa047422.42810467
11Amphetamine addiction_Homo sapiens_hsa050312.28795594
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.27376314
13Synaptic vesicle cycle_Homo sapiens_hsa047212.16779270
14GABAergic synapse_Homo sapiens_hsa047272.14488807
15Protein export_Homo sapiens_hsa030602.10280056
16Circadian entrainment_Homo sapiens_hsa047132.02733186
17Morphine addiction_Homo sapiens_hsa050322.01785730
18Glutathione metabolism_Homo sapiens_hsa004802.00048190
19Serotonergic synapse_Homo sapiens_hsa047261.95636320
20Glutamatergic synapse_Homo sapiens_hsa047241.93779985
21Insulin secretion_Homo sapiens_hsa049111.92696502
22beta-Alanine metabolism_Homo sapiens_hsa004101.88364068
23Vibrio cholerae infection_Homo sapiens_hsa051101.86711570
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85799886
25Tyrosine metabolism_Homo sapiens_hsa003501.76235907
26Phototransduction_Homo sapiens_hsa047441.70796151
27Cocaine addiction_Homo sapiens_hsa050301.70277256
28RNA polymerase_Homo sapiens_hsa030201.70003414
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69863877
30Phenylalanine metabolism_Homo sapiens_hsa003601.69159130
31Cardiac muscle contraction_Homo sapiens_hsa042601.65226349
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63663449
33Dopaminergic synapse_Homo sapiens_hsa047281.63581160
34Long-term potentiation_Homo sapiens_hsa047201.60056557
35Renin secretion_Homo sapiens_hsa049241.58254590
36Histidine metabolism_Homo sapiens_hsa003401.53380545
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50945715
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49285480
39Retinol metabolism_Homo sapiens_hsa008301.48865531
40Caffeine metabolism_Homo sapiens_hsa002321.47976416
41Gastric acid secretion_Homo sapiens_hsa049711.44023813
42Salivary secretion_Homo sapiens_hsa049701.40424829
43Calcium signaling pathway_Homo sapiens_hsa040201.36715952
44Basal transcription factors_Homo sapiens_hsa030221.32841067
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29955229
46Propanoate metabolism_Homo sapiens_hsa006401.27842905
47Peroxisome_Homo sapiens_hsa041461.23688504
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20480701
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.19271718
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16574822
51Sulfur metabolism_Homo sapiens_hsa009201.13876150
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09502805
53Cholinergic synapse_Homo sapiens_hsa047251.07983142
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06969986
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06278170
56Long-term depression_Homo sapiens_hsa047301.06212121
57Rheumatoid arthritis_Homo sapiens_hsa053231.04891792
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04222237
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97672960
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94862593
61Tryptophan metabolism_Homo sapiens_hsa003800.94387101
62cAMP signaling pathway_Homo sapiens_hsa040240.93496752
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93295623
64Asthma_Homo sapiens_hsa053100.91442422
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90861886
66Ether lipid metabolism_Homo sapiens_hsa005650.90383403
67Axon guidance_Homo sapiens_hsa043600.90183136
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87864918
69Oxytocin signaling pathway_Homo sapiens_hsa049210.79842528
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79709939
71Sphingolipid metabolism_Homo sapiens_hsa006000.79208685
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.78157436
73Fanconi anemia pathway_Homo sapiens_hsa034600.77681179
74Melanogenesis_Homo sapiens_hsa049160.77251233
75Folate biosynthesis_Homo sapiens_hsa007900.76657655
76Pancreatic secretion_Homo sapiens_hsa049720.76186902
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.76036383
78Thyroid hormone synthesis_Homo sapiens_hsa049180.75986538
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74097988
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.72796263
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71521016
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71345051
83Allograft rejection_Homo sapiens_hsa053300.71272915
84Pyrimidine metabolism_Homo sapiens_hsa002400.70755511
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69646686
86Alcoholism_Homo sapiens_hsa050340.67258564
87Homologous recombination_Homo sapiens_hsa034400.67107547
88Arachidonic acid metabolism_Homo sapiens_hsa005900.66252947
89Gap junction_Homo sapiens_hsa045400.64600203
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64437420
91Autoimmune thyroid disease_Homo sapiens_hsa053200.62925004
92GnRH signaling pathway_Homo sapiens_hsa049120.62628879
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62384328
94Circadian rhythm_Homo sapiens_hsa047100.59745496
95Glucagon signaling pathway_Homo sapiens_hsa049220.59734101
96Mineral absorption_Homo sapiens_hsa049780.59202066
97Nitrogen metabolism_Homo sapiens_hsa009100.58943572
98Estrogen signaling pathway_Homo sapiens_hsa049150.58303572
99Graft-versus-host disease_Homo sapiens_hsa053320.57232156
100Butanoate metabolism_Homo sapiens_hsa006500.56338804
101Phagosome_Homo sapiens_hsa041450.55489292
102Fatty acid degradation_Homo sapiens_hsa000710.55417821
103Fatty acid elongation_Homo sapiens_hsa000620.51999738
104African trypanosomiasis_Homo sapiens_hsa051430.51985871
105Ovarian steroidogenesis_Homo sapiens_hsa049130.51624579
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51488066
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49340790
108Nucleotide excision repair_Homo sapiens_hsa034200.48698990
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.48530238
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47895881
111Starch and sucrose metabolism_Homo sapiens_hsa005000.47556723
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47541462
113Linoleic acid metabolism_Homo sapiens_hsa005910.46502867
114Basal cell carcinoma_Homo sapiens_hsa052170.46035923
115Vitamin digestion and absorption_Homo sapiens_hsa049770.46003297
116Type I diabetes mellitus_Homo sapiens_hsa049400.45733367
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45678736
118RNA degradation_Homo sapiens_hsa030180.45027055
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.44536276
120Mismatch repair_Homo sapiens_hsa034300.44145450
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42878738
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41382276
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41040388
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38922733
125Fatty acid biosynthesis_Homo sapiens_hsa000610.38724712
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.38153210
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.38117986
128Purine metabolism_Homo sapiens_hsa002300.38087178
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37845983
130Proteasome_Homo sapiens_hsa030500.37084920
131Pyruvate metabolism_Homo sapiens_hsa006200.36852357
132Vitamin B6 metabolism_Homo sapiens_hsa007500.36502280
133Wnt signaling pathway_Homo sapiens_hsa043100.36454492
134Metabolic pathways_Homo sapiens_hsa011000.35499915
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34696317
136Hedgehog signaling pathway_Homo sapiens_hsa043400.33402113
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32651634
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31862365
139Prion diseases_Homo sapiens_hsa050200.31350830
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30425499
141Steroid biosynthesis_Homo sapiens_hsa001000.30091914
142N-Glycan biosynthesis_Homo sapiens_hsa005100.29058879
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28881054
144Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27425248
145Dorso-ventral axis formation_Homo sapiens_hsa043200.26310855
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23991204
147Regulation of autophagy_Homo sapiens_hsa041400.22535828
148Other glycan degradation_Homo sapiens_hsa005110.20291933
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19935569

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