RSPH6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to a sea urchin radial spoke head protein. Radial spoke protein complexes form part of the axoneme of eukaryotic flagella and are located between the axoneme's outer ring of doublet microtubules and central pair of microtubules. In Chlamydomonas, radial spoke proteins are thought to regulate the activity of dynein and the symmetry of flagellar bending patterns. This gene maps to a region of chromosome 19 that is linked to primary ciliary dyskinesia-2 (CILD2). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.99791353
2plasma membrane fusion (GO:0045026)9.66205462
3spermatid development (GO:0007286)9.52445111
4motile cilium assembly (GO:0044458)9.43964205
5piRNA metabolic process (GO:0034587)9.38481266
6reproduction (GO:0000003)8.93766389
7regulation of cilium movement (GO:0003352)8.73987525
8cilium movement (GO:0003341)8.59908300
9male meiosis (GO:0007140)8.48015564
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.20955458
11synaptonemal complex organization (GO:0070193)8.03824325
12synaptonemal complex assembly (GO:0007130)7.78137821
13rRNA methylation (GO:0031167)7.64446799
14sperm capacitation (GO:0048240)7.44521010
15single fertilization (GO:0007338)7.27381356
16negative regulation of inclusion body assembly (GO:0090084)6.70028952
17spermatogenesis (GO:0007283)6.30850261
18fertilization (GO:0009566)6.28646797
19male gamete generation (GO:0048232)6.28549233
20rRNA modification (GO:0000154)6.24443836
21organic cation transport (GO:0015695)5.97901874
22DNA methylation involved in gamete generation (GO:0043046)5.87871463
23cellular response to ATP (GO:0071318)5.86907438
24adenosine receptor signaling pathway (GO:0001973)5.83777875
25male meiosis I (GO:0007141)5.79416925
26gamete generation (GO:0007276)5.77555030
27microtubule depolymerization (GO:0007019)5.65669930
28ventricular system development (GO:0021591)5.62410551
29purinergic nucleotide receptor signaling pathway (GO:0035590)5.55621775
30regulation of inclusion body assembly (GO:0090083)5.49712934
31germ cell development (GO:0007281)5.42022074
32chromosome organization involved in meiosis (GO:0070192)5.40822996
33cellular process involved in reproduction in multicellular organism (GO:0022412)5.39192861
34microtubule severing (GO:0051013)5.14312321
35regulation of microtubule-based movement (GO:0060632)5.13036556
36calcium ion-dependent exocytosis (GO:0017156)5.04631467
37meiotic nuclear division (GO:0007126)4.95675142
38cell recognition (GO:0008037)4.91956053
39seminiferous tubule development (GO:0072520)4.90988217
40regulation of activation of Janus kinase activity (GO:0010533)4.90692684
41regulation of chemokine-mediated signaling pathway (GO:0070099)4.77901562
42DNA strand renaturation (GO:0000733)4.77033386
43meiosis I (GO:0007127)4.68937041
44meiotic chromosome segregation (GO:0045132)4.67137692
45left/right pattern formation (GO:0060972)4.57024593
46multicellular organismal reproductive process (GO:0048609)4.54240007
47G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.53442974
48purinergic receptor signaling pathway (GO:0035587)4.41839613
49phosphatidylethanolamine biosynthetic process (GO:0006646)4.40919767
50phosphatidylethanolamine metabolic process (GO:0046337)4.39753902
51regulation of chronic inflammatory response (GO:0002676)4.33316711
52eosinophil chemotaxis (GO:0048245)4.31002189
53urinary tract smooth muscle contraction (GO:0014848)4.24610444
54protein localization to cilium (GO:0061512)4.21731541
55meiotic cell cycle (GO:0051321)4.21544711
56spermatid nucleus differentiation (GO:0007289)4.19048779
57protein polyglutamylation (GO:0018095)4.10265181
58peristalsis (GO:0030432)4.10115096
59chromosome condensation (GO:0030261)4.09432804
60response to pheromone (GO:0019236)4.05208945
61DNA packaging (GO:0006323)3.97625777
62leukotriene biosynthetic process (GO:0019370)3.96572666
63negative regulation of cell aging (GO:0090344)3.96368880
64sensory perception of taste (GO:0050909)3.95381146
65regulation of skeletal muscle contraction (GO:0014819)3.92276338
66regulation of protein kinase A signaling (GO:0010738)3.83993989
67signal peptide processing (GO:0006465)3.83042115
68negative regulation by host of viral transcription (GO:0043922)3.82970046
69eosinophil migration (GO:0072677)3.82642257
70genitalia morphogenesis (GO:0035112)3.81870575
71monoubiquitinated protein deubiquitination (GO:0035520)3.81728070
72chaperone-mediated protein complex assembly (GO:0051131)3.80048875
73lens fiber cell differentiation (GO:0070306)3.76185451
74glycerol ether metabolic process (GO:0006662)3.75003852
75multicellular organismal development (GO:0007275)3.68199401
76response to acidic pH (GO:0010447)3.63300506
77positive regulation of protein kinase C signaling (GO:0090037)3.61781526
78polyamine biosynthetic process (GO:0006596)3.56590607
79positive regulation of monocyte chemotaxis (GO:0090026)3.53512214
80intraciliary transport (GO:0042073)3.52370472
81response to ATP (GO:0033198)3.52200303
82positive regulation of catecholamine secretion (GO:0033605)3.50856148
83gene silencing by RNA (GO:0031047)3.49957590
84ether metabolic process (GO:0018904)3.45918063
85negative regulation of T cell apoptotic process (GO:0070233)3.45157819
86positive regulation of Rab GTPase activity (GO:0032851)3.41618300
87regulation of Rab GTPase activity (GO:0032313)3.41618300
88regulation of mononuclear cell migration (GO:0071675)3.40616461
89negative regulation of organelle assembly (GO:1902116)3.37372253
90regulation of spindle checkpoint (GO:0090231)3.33561678
91amino-acid betaine transport (GO:0015838)3.32135250
92carnitine transport (GO:0015879)3.32135250
93mitochondrion distribution (GO:0048311)3.29517714
94synapsis (GO:0007129)3.25801393
95RNA destabilization (GO:0050779)3.25693459
96carnitine transmembrane transport (GO:1902603)3.25563137
97meiotic cell cycle process (GO:1903046)3.23993347
98microtubule-based movement (GO:0007018)3.23955635
99regulation of T cell chemotaxis (GO:0010819)3.23548789
100positive regulation of T cell chemotaxis (GO:0010820)3.23548789
101activation of adenylate cyclase activity (GO:0007190)3.23192291
102chromatin silencing (GO:0006342)3.23035506
103G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.21086781
104glutathione metabolic process (GO:0006749)3.20382511
105axoneme assembly (GO:0035082)3.16024550
106protein refolding (GO:0042026)3.12663232
107mRNA cleavage (GO:0006379)3.11059990
108histone mRNA catabolic process (GO:0071044)3.07736484
109cilium organization (GO:0044782)3.04803055
110single strand break repair (GO:0000012)3.04185558
111behavioral response to nicotine (GO:0035095)3.03339809
112regulation of phosphoprotein phosphatase activity (GO:0043666)2.97784108
113spinal cord motor neuron differentiation (GO:0021522)2.97437008
114protein K11-linked deubiquitination (GO:0035871)2.96460396
115mitotic sister chromatid cohesion (GO:0007064)2.95550702
116GDP-mannose metabolic process (GO:0019673)2.94686305
117detection of light stimulus involved in visual perception (GO:0050908)2.93825260
118detection of light stimulus involved in sensory perception (GO:0050962)2.93825260
119regulation of centriole replication (GO:0046599)2.93387728
120regulation of synapse structural plasticity (GO:0051823)2.91010238
121cilium assembly (GO:0042384)2.89496401
122nucleus organization (GO:0006997)2.89396557
123establishment of protein localization to Golgi (GO:0072600)2.89243909
124cilium morphogenesis (GO:0060271)2.89123747
125sex determination (GO:0007530)2.89020363
126lactate metabolic process (GO:0006089)2.87095243
127nucleoside diphosphate phosphorylation (GO:0006165)2.86548110
128alditol metabolic process (GO:0019400)2.85936906
129positive regulation of protein sumoylation (GO:0033235)2.85687286
130peptidyl-glutamic acid modification (GO:0018200)2.85361227
131glycolytic process (GO:0006096)2.84528490
132microtubule polymerization or depolymerization (GO:0031109)2.83107850
133cellular component assembly involved in morphogenesis (GO:0010927)2.83016713
134positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.81898879
135regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.81686959
136regulation of circadian sleep/wake cycle (GO:0042749)2.81686959
137polyol catabolic process (GO:0046174)2.81401663
138centriole replication (GO:0007099)2.79577721
139protein targeting to Golgi (GO:0000042)2.79100620
140positive regulation of translational initiation (GO:0045948)2.77815794
141nuclear pore complex assembly (GO:0051292)2.77133239
142response to misfolded protein (GO:0051788)2.77043418
143gene silencing (GO:0016458)2.70726756
144RNA localization (GO:0006403)2.65177618
145interferon-gamma secretion (GO:0072643)2.64133749
146sexual reproduction (GO:0019953)2.63118150
147sequestering of actin monomers (GO:0042989)2.53771872
148regulation of meiosis I (GO:0060631)2.52192292
149centriole assembly (GO:0098534)2.47246150
150regulation of cilium assembly (GO:1902017)2.46014060
151positive regulation of macrophage activation (GO:0043032)2.43441394
152GTP biosynthetic process (GO:0006183)2.42165541
153sperm motility (GO:0030317)13.1030655
154cilium or flagellum-dependent cell motility (GO:0001539)13.0324414
155fusion of sperm to egg plasma membrane (GO:0007342)12.7149547
156sperm-egg recognition (GO:0035036)11.3876734
157acrosome assembly (GO:0001675)11.3434338
158acrosome reaction (GO:0007340)11.3162158
159multicellular organism reproduction (GO:0032504)10.7395160
160axonemal dynein complex assembly (GO:0070286)10.6628435
161cell wall macromolecule metabolic process (GO:0044036)10.6301459
162cell wall macromolecule catabolic process (GO:0016998)10.6301459
163binding of sperm to zona pellucida (GO:0007339)10.4440003
164cell-cell recognition (GO:0009988)10.1891567

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.25474909
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.74607143
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.00334203
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.17139792
5P68_20966046_ChIP-Seq_HELA_Human3.02682514
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.76986010
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73548860
8BCL6_27268052_Chip-Seq_Bcells_Human2.59058927
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.57822279
10VDR_21846776_ChIP-Seq_THP-1_Human2.53959696
11E2F1_20622854_ChIP-Seq_HELA_Human2.47641567
12BCOR_27268052_Chip-Seq_Bcells_Human2.44906953
13PHF8_20622854_ChIP-Seq_HELA_Human2.44397217
14* MAF_26560356_Chip-Seq_TH2_Human2.42713292
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33095795
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.29543076
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.27396248
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.24899383
19* LXR_22292898_ChIP-Seq_THP-1_Human2.23494457
20VDR_22108803_ChIP-Seq_LS180_Human2.23374234
21EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.22025171
22NANOG_20526341_ChIP-Seq_ESCs_Human2.20082858
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11840152
24* ERA_21632823_ChIP-Seq_H3396_Human2.11633650
25SMC4_20622854_ChIP-Seq_HELA_Human2.11360392
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10622096
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.10495282
28RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.08474278
29ZNF274_21170338_ChIP-Seq_K562_Hela2.07125132
30* CTCF_27219007_Chip-Seq_Bcells_Human2.05430533
31IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02973277
32FLI1_27457419_Chip-Seq_LIVER_Mouse2.02107623
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.6379190
34VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.93120967
35SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.92612173
36OCT4_20526341_ChIP-Seq_ESCs_Human1.92016513
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.84815637
38* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.84712622
39P300_27268052_Chip-Seq_Bcells_Human1.81683856
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81426760
41TAF2_19829295_ChIP-Seq_ESCs_Human1.80355863
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75536334
43MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.65467588
44* CTCF_21964334_Chip-Seq_Bcells_Human1.64960711
45RAC3_21632823_ChIP-Seq_H3396_Human1.64655489
46KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.63540787
47TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.63022674
48STAT1_17558387_ChIP-Seq_HELA_Human1.61633716
49* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61187118
50MYC_19829295_ChIP-Seq_ESCs_Human1.59193825
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57742863
52* UTX_26944678_Chip-Seq_JUKART_Human1.56028095
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54820276
54TAF15_26573619_Chip-Seq_HEK293_Human1.50715148
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.49742968
56SA1_27219007_Chip-Seq_Bcells_Human1.49578849
57GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.48945472
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47164560
59FOXP1_21924763_ChIP-Seq_HESCs_Human1.45603996
60SOX2_22085726_ChIP-Seq_NPCs_Mouse1.45037645
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43015797
62CBP_20019798_ChIP-Seq_JUKART_Human1.42981227
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42981227
64GATA3_21867929_ChIP-Seq_CD8_Mouse1.42231457
65RARB_24833708_ChIP-Seq_LIVER_Mouse1.41636792
66TP63_22573176_ChIP-Seq_HFKS_Human1.40548048
67P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.39793633
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39700667
69* MAF_26560356_Chip-Seq_TH1_Human1.39482910
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38256926
71* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38114641
72PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38028745
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37639205
74KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36480247
75CTCF_21964334_ChIP-Seq_BJAB-B_Human1.36046526
76VDR_24763502_ChIP-Seq_THP-1_Human1.34948267
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33172519
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.32638311
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.32560627
80DROSHA_22980978_ChIP-Seq_HELA_Human1.31471904
81FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29974550
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29788765
83KDM2B_26808549_Chip-Seq_REH_Human1.29549271
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26923379
85IRF8_21731497_ChIP-ChIP_J774_Mouse1.26608508
86LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.26028365
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.25725600
88REST_21632747_ChIP-Seq_MESCs_Mouse1.25227323
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24431381
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.23863231
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23522229
92P53_21459846_ChIP-Seq_SAOS-2_Human1.21224304
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.19965647
94OCT4_19829295_ChIP-Seq_ESCs_Human1.19799361
95SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19744781
96TP53_22127205_ChIP-Seq_IMR90_Human1.19733584
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19495956
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.18861402
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16116917
100RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15787552
101GATA3_21867929_ChIP-Seq_TH1_Mouse1.15517492
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15084774
103SPI1_20517297_ChIP-Seq_HL60_Human1.14335307
104RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14210949
105TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.13692640
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12877653
107GF1_26923725_Chip-Seq_HPCs_Mouse1.12486898
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11549130
109HOXB7_26014856_ChIP-Seq_BT474_Human1.11510475
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11369218
111FUS_26573619_Chip-Seq_HEK293_Human1.11067185
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09144345
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09144345
114CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08502270
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08500950
116CIITA_25753668_ChIP-Seq_RAJI_Human1.08190184
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07878548
118* XRN2_22483619_ChIP-Seq_HELA_Human1.07639623
119PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07128332
120ETS1_21867929_ChIP-Seq_TH2_Mouse1.06176360
121TP53_22573176_ChIP-Seq_HFKS_Human1.05955229
122RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05254641
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.05127455
124SPI1_26923725_Chip-Seq_HPCs_Mouse1.04646064
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04257427
126PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03568412
127CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03542738
128PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03042813
129AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02819702
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02204024
131NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.02147707
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01587412
133YY1_22570637_ChIP-Seq_MALME-3M_Human1.01472475
134RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00759101
135SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00167848
136ERG_21242973_ChIP-ChIP_JURKAT_Human0.99987449
137OCT4_18555785_Chip-Seq_ESCs_Mouse0.99964340
138RNF2_27304074_Chip-Seq_NSC_Mouse0.99869897
139CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99678022
140ERG_20517297_ChIP-Seq_VCAP_Human0.99449307
141RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99162105
142AR_21572438_ChIP-Seq_LNCaP_Human0.99066584
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98693398
144GATA1_19941826_ChIP-Seq_K562_Human0.98173620
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.98119942
146CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98064498
147MYC_27129775_Chip-Seq_CORNEA_Mouse0.97949913
148RARA_24833708_ChIP-Seq_LIVER_Mouse0.97239187
149ESET_19884257_ChIP-Seq_ESCs_Mouse0.97081701
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96932998
151CSB_26484114_Chip-Seq_FIBROBLAST_Human0.96834647
152RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96752803
153EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96166592
154PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95236742
155OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92882636
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92772467
157NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92201781
158ELF1_20517297_ChIP-Seq_JURKAT_Human0.91945500
159P53_22387025_ChIP-Seq_ESCs_Mouse0.90610079
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90527484
161EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90461974
162EZH2_27294783_Chip-Seq_NPCs_Mouse0.90095310
163KLF4_18555785_Chip-Seq_ESCs_Mouse0.89851837
164GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88704930
165ESRRB_18555785_Chip-Seq_ESCs_Mouse0.88395485
166EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88345399
167FLI1_21867929_ChIP-Seq_CD8_Mouse0.88074139
168SOX2_21211035_ChIP-Seq_LN229_Human0.87866246
169RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87853066
170P300_18555785_Chip-Seq_ESCs_Mouse0.86907261
171LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86569063
172TET1_21451524_ChIP-Seq_MESCs_Mouse0.86483669
173SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85842979
174CTCF_20526341_ChIP-Seq_ESCs_Human0.84977530
175MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84129363
176CMYC_18555785_Chip-Seq_ESCs_Mouse0.83100966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.03319693
2MP0005174_abnormal_tail_pigmentation5.67711702
3MP0001929_abnormal_gametogenesis5.52502104
4MP0005171_absent_coat_pigmentation4.83183507
5MP0003136_yellow_coat_color4.78829060
6MP0008877_abnormal_DNA_methylation4.70934251
7MP0001968_abnormal_touch/_nociception3.67412801
8MP0002210_abnormal_sex_determination3.63644408
9MP0002161_abnormal_fertility/fecundity3.27942969
10MP0002653_abnormal_ependyma_morphology3.17905684
11MP0001188_hyperpigmentation3.15270436
12MP0001145_abnormal_male_reproductive3.08595639
13MP0000653_abnormal_sex_gland2.65941466
14MP0000015_abnormal_ear_pigmentation2.48284659
15MP0005671_abnormal_response_to2.34021027
16MP0005670_abnormal_white_adipose2.25214913
17MP0005623_abnormal_meninges_morphology2.22708132
18MP0002735_abnormal_chemical_nociception2.17158536
19MP0005409_darkened_coat_color2.03868577
20MP0005410_abnormal_fertilization15.8375270
21MP0002160_abnormal_reproductive_system1.80743789
22MP0005083_abnormal_biliary_tract1.77345199
23MP0005379_endocrine/exocrine_gland_phen1.75420250
24MP0002638_abnormal_pupillary_reflex1.70542266
25MP0001905_abnormal_dopamine_level1.70503943
26MP0004381_abnormal_hair_follicle1.66915538
27MP0003646_muscle_fatigue1.63722606
28MP0002282_abnormal_trachea_morphology1.49788510
29MP0001756_abnormal_urination1.48252113
30MP0008004_abnormal_stomach_pH1.38063549
31MP0001502_abnormal_circadian_rhythm1.36513933
32MP0000538_abnormal_urinary_bladder1.25256198
33MP0004233_abnormal_muscle_weight1.23571477
34MP0001970_abnormal_pain_threshold1.22651934
35MP0008058_abnormal_DNA_repair1.22369969
36MP0008875_abnormal_xenobiotic_pharmacok1.20493376
37MP0003183_abnormal_peptide_metabolism1.16581285
38MP0005464_abnormal_platelet_physiology1.15488404
39MP0008057_abnormal_DNA_replication1.14926493
40MP0009046_muscle_twitch1.14696757
41MP0005084_abnormal_gallbladder_morpholo1.08963095
42MP0003172_abnormal_lysosome_physiology1.07793680
43MP0001348_abnormal_lacrimal_gland1.07360588
44MP0004043_abnormal_pH_regulation1.07263844
45MP0003718_maternal_effect1.06924937
46MP0004145_abnormal_muscle_electrophysio1.04924072
47MP0006276_abnormal_autonomic_nervous1.02905126
48MP0000470_abnormal_stomach_morphology1.01908228
49MP0000678_abnormal_parathyroid_gland1.00664964
50MP0005647_abnormal_sex_gland0.99700857
51MP0001984_abnormal_olfaction0.99487806
52MP0009764_decreased_sensitivity_to0.99286885
53MP0010386_abnormal_urinary_bladder0.97459192
54MP0001765_abnormal_ion_homeostasis0.94327007
55MP0001664_abnormal_digestion0.93439599
56MP0010094_abnormal_chromosome_stability0.91604356
57MP0005389_reproductive_system_phenotype0.88759203
58MP0000681_abnormal_thyroid_gland0.84176194
59MP0001873_stomach_inflammation0.82818740
60MP0008995_early_reproductive_senescence0.81783248
61MP0003011_delayed_dark_adaptation0.81270535
62MP0000613_abnormal_salivary_gland0.81194433
63MP0002733_abnormal_thermal_nociception0.79553829
64MP0003878_abnormal_ear_physiology0.79033093
65MP0005377_hearing/vestibular/ear_phenot0.79033093
66MP0002723_abnormal_immune_serum0.78393344
67MP0000569_abnormal_digit_pigmentation0.78159497
68MP0000371_diluted_coat_color0.76494146
69MP0003315_abnormal_perineum_morphology0.76207731
70MP0005332_abnormal_amino_acid0.75842899
71MP0005310_abnormal_salivary_gland0.74626714
72MP0005220_abnormal_exocrine_pancreas0.74235164
73MP0000013_abnormal_adipose_tissue0.70669392
74MP0003115_abnormal_respiratory_system0.69983969
75MP0008260_abnormal_autophagy0.69745165
76MP0004130_abnormal_muscle_cell0.69084826
77MP0002234_abnormal_pharynx_morphology0.68178375
78MP0008007_abnormal_cellular_replicative0.66274042
79MP0002398_abnormal_bone_marrow0.66219933
80MP0001800_abnormal_humoral_immune0.65573710
81MP0003137_abnormal_impulse_conducting0.64513627
82MP0000230_abnormal_systemic_arterial0.63160924
83MP0005584_abnormal_enzyme/coenzyme_acti0.63117705
84MP0003448_altered_tumor_morphology0.62274171
85MP0001835_abnormal_antigen_presentation0.62017495
86MP0003111_abnormal_nucleus_morphology0.61798828
87MP0009053_abnormal_anal_canal0.60450649
88MP0002877_abnormal_melanocyte_morpholog0.60410787
89MP0005058_abnormal_lysosome_morphology0.59185886
90MP0001293_anophthalmia0.58067628
91MP0000358_abnormal_cell_content/0.58002000
92MP0001545_abnormal_hematopoietic_system0.56954080
93MP0005397_hematopoietic_system_phenotyp0.56954080
94MP0003786_premature_aging0.56524441
95MP0009643_abnormal_urine_homeostasis0.56162738
96MP0003950_abnormal_plasma_membrane0.55466911
97MP0002163_abnormal_gland_morphology0.54247436
98MP0009278_abnormal_bone_marrow0.53984429
99MP0002822_catalepsy0.53858767
100MP0002452_abnormal_antigen_presenting0.53224192
101MP0003091_abnormal_cell_migration0.52414178
102MP0005166_decreased_susceptibility_to0.51908350
103MP0002067_abnormal_sensory_capabilities0.50703434
104MP0005375_adipose_tissue_phenotype0.50601943
105MP0003699_abnormal_female_reproductive0.50496381
106MP0002928_abnormal_bile_duct0.49293536
107MP0004957_abnormal_blastocyst_morpholog0.49114005
108MP0002722_abnormal_immune_system0.48420471
109MP0005423_abnormal_somatic_nervous0.48383511
110MP0005666_abnormal_adipose_tissue0.46528345
111MP0002136_abnormal_kidney_physiology0.46336002
112MP0002429_abnormal_blood_cell0.45922338
113MP0005636_abnormal_mineral_homeostasis0.45593127
114MP0003329_amyloid_beta_deposits0.42606640
115MP0004036_abnormal_muscle_relaxation0.42253244
116MP0001324_abnormal_eye_pigmentation0.42001502
117MP0001730_embryonic_growth_arrest0.41806926
118MP0004808_abnormal_hematopoietic_stem0.41551751
119MP0004134_abnormal_chest_morphology0.40370616
120MP0004133_heterotaxia0.39657986
121MP0005253_abnormal_eye_physiology0.38088285
122MP0005391_vision/eye_phenotype0.37449308
123MP0002269_muscular_atrophy0.36817903
124MP0005551_abnormal_eye_electrophysiolog0.35370986
125MP0002102_abnormal_ear_morphology0.34552034
126MP0001119_abnormal_female_reproductive0.34340091
127MP0010307_abnormal_tumor_latency0.33145410
128MP0003861_abnormal_nervous_system0.32597452
129MP0001764_abnormal_homeostasis0.30978859
130MP0000534_abnormal_ureter_morphology0.29355453
131MP0006036_abnormal_mitochondrial_physio0.29201308
132MP0009115_abnormal_fat_cell0.28417322
133MP0002092_abnormal_eye_morphology0.28249621
134MP0000313_abnormal_cell_death0.28133390
135MP0002152_abnormal_brain_morphology0.26693481
136MP0002971_abnormal_brown_adipose0.26486725
137MP0003077_abnormal_cell_cycle0.26273689
138MP0003942_abnormal_urinary_system0.26061855
139MP0004811_abnormal_neuron_physiology0.26047626
140MP0003879_abnormal_hair_cell0.25578684
141MP0002084_abnormal_developmental_patter0.25086890
142MP0004019_abnormal_vitamin_homeostasis0.24216789
143MP0003045_fibrosis0.23372731
144MP0001727_abnormal_embryo_implantation0.22956592
145MP0008961_abnormal_basal_metabolism0.22361641
146MP0003633_abnormal_nervous_system0.22062202
147MP0001661_extended_life_span0.20818801
148MP0003948_abnormal_gas_homeostasis0.19218473
149MP0001672_abnormal_embryogenesis/_devel0.19218301
150MP0005380_embryogenesis_phenotype0.19218301
151MP0002736_abnormal_nociception_after0.18812148
152MP0003631_nervous_system_phenotype0.18500280
153MP0002169_no_abnormal_phenotype0.18376216
154MP0000751_myopathy0.18171051
155MP0002873_normal_phenotype0.18099587
156MP0003787_abnormal_imprinting0.17608454
157MP0002295_abnormal_pulmonary_circulatio0.17493629
158MP0001697_abnormal_embryo_size0.16537307
159MP0000604_amyloidosis0.14486882
160MP0004742_abnormal_vestibular_system0.14337402
161MP0001986_abnormal_taste_sensitivity0.13684350
162MP0003984_embryonic_growth_retardation0.13495599
163MP0000432_abnormal_head_morphology0.13053146
164MP0000001_mammalian_phenotype0.12923661
165MP0002229_neurodegeneration0.12858970
166MP0001849_ear_inflammation0.12256811
167MP0003936_abnormal_reproductive_system0.12137113
168MP0002085_abnormal_embryonic_tissue0.11869394
169MP0002132_abnormal_respiratory_system0.11838012

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.30896202
2Abnormal respiratory motile cilium morphology (HP:0005938)8.79755619
3Abnormal respiratory epithelium morphology (HP:0012253)8.79755619
4Rhinitis (HP:0012384)7.88468272
5Abnormal ciliary motility (HP:0012262)7.32328116
6Chronic bronchitis (HP:0004469)7.21692069
7Infertility (HP:0000789)6.65958132
8Nasal polyposis (HP:0100582)6.49211172
9Attenuation of retinal blood vessels (HP:0007843)6.07627298
10Abnormality of the nasal mucosa (HP:0000433)5.33135050
11Bony spicule pigmentary retinopathy (HP:0007737)4.89977244
12Bronchitis (HP:0012387)4.69481524
13Nephronophthisis (HP:0000090)4.65242859
14Bronchiectasis (HP:0002110)4.64379960
15Congenital stationary night blindness (HP:0007642)4.63874509
16Rectal fistula (HP:0100590)4.51459597
17Rectovaginal fistula (HP:0000143)4.51459597
18Intestinal fistula (HP:0100819)4.45810994
19Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.29353727
20Vaginal fistula (HP:0004320)4.06148783
21Male infertility (HP:0003251)3.96908399
22Rib fusion (HP:0000902)3.91858818
23Facial hemangioma (HP:0000329)3.70189178
24Abnormality of the intrinsic pathway (HP:0010989)3.67666108
25Abnormality of the renal medulla (HP:0100957)3.53656346
26Recurrent otitis media (HP:0000403)3.48660145
27Facial diplegia (HP:0001349)3.44551372
28Renal Fanconi syndrome (HP:0001994)3.39593039
29Squamous cell carcinoma (HP:0002860)3.37768970
30Abnormal spermatogenesis (HP:0008669)3.31593888
31Poikiloderma (HP:0001029)3.30271518
32Testicular atrophy (HP:0000029)3.28088105
33Fetal akinesia sequence (HP:0001989)3.26001852
34Popliteal pterygium (HP:0009756)3.22075612
35Recurrent sinusitis (HP:0011108)3.18737877
36Decreased electroretinogram (ERG) amplitude (HP:0000654)3.11743054
37Chorioretinal atrophy (HP:0000533)3.05407336
38Recurrent bronchitis (HP:0002837)3.01341160
39Absent thumb (HP:0009777)2.99918348
40Thin bony cortex (HP:0002753)2.99396505
41Capillary hemangiomas (HP:0005306)2.96434855
42Enlarged epiphyses (HP:0010580)2.93675315
43Annular pancreas (HP:0001734)2.92226035
44Tubulointerstitial nephritis (HP:0001970)2.91349344
45Gonadotropin excess (HP:0000837)2.87171189
46Abnormality of the lower motor neuron (HP:0002366)2.84669556
47Joint hemorrhage (HP:0005261)2.82025838
48Abnormality of the costochondral junction (HP:0000919)2.77645409
49Ulnar bowing (HP:0003031)2.73829162
50Impulsivity (HP:0100710)2.72936764
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71780895
52Prolonged partial thromboplastin time (HP:0003645)2.69721934
53Congenital sensorineural hearing impairment (HP:0008527)2.68555489
54Severe visual impairment (HP:0001141)2.68487640
55Hypophosphatemic rickets (HP:0004912)2.67381469
56Molar tooth sign on MRI (HP:0002419)2.63943907
57Abnormality of midbrain morphology (HP:0002418)2.63943907
58Tubular atrophy (HP:0000092)2.62906264
59Hypoalbuminemia (HP:0003073)2.61707464
60Abnormal albumin level (HP:0012116)2.61707464
61Delayed epiphyseal ossification (HP:0002663)2.60106283
62Aplasia of the musculature (HP:0100854)2.58684669
63Abnormality of dental color (HP:0011073)2.54725462
64Tubulointerstitial abnormality (HP:0001969)2.53497819
65Akinesia (HP:0002304)2.52215456
66Abnormality of T cell number (HP:0011839)2.48507538
67Generalized aminoaciduria (HP:0002909)2.42813902
68T lymphocytopenia (HP:0005403)2.42656496
69Anteriorly placed anus (HP:0001545)2.41404040
70Medial flaring of the eyebrow (HP:0010747)2.35445251
71Widely patent fontanelles and sutures (HP:0004492)2.32254799
72Visual hallucinations (HP:0002367)2.31721429
73Azoospermia (HP:0000027)2.31528697
74Atrioventricular block (HP:0001678)2.30185294
75Amyotrophic lateral sclerosis (HP:0007354)2.29748566
76Lipid accumulation in hepatocytes (HP:0006561)2.28766580
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23903498
78Fibular hypoplasia (HP:0003038)2.20618029
79Pendular nystagmus (HP:0012043)2.19564644
80Abnormality of the hepatic vasculature (HP:0006707)2.18414593
81Postaxial foot polydactyly (HP:0001830)2.15978294
82Abnormality of the common coagulation pathway (HP:0010990)2.15797678
83Increased hepatocellular lipid droplets (HP:0006565)2.14904232
84Resting tremor (HP:0002322)2.14832081
85Turricephaly (HP:0000262)2.12615881
86Short chin (HP:0000331)2.10627535
87Abnormality of renal resorption (HP:0011038)2.09483529
88Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08641242
89Muscle fiber atrophy (HP:0100295)2.08361720
90Tubulointerstitial fibrosis (HP:0005576)2.07309736
91Basal cell carcinoma (HP:0002671)2.06489075
92Amniotic constriction ring (HP:0009775)2.05549561
93Abnormality of placental membranes (HP:0011409)2.05549561
94Polyuria (HP:0000103)2.03609217
95Cholecystitis (HP:0001082)2.00572545
96Abnormal gallbladder physiology (HP:0012438)2.00572545
97Macular degeneration (HP:0000608)2.00178782
98Congenital hepatic fibrosis (HP:0002612)2.00146033
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6828837
100Dynein arm defect of respiratory motile cilia (HP:0012255)12.5976742
101Absent/shortened dynein arms (HP:0200106)12.5976742
102Stage 5 chronic kidney disease (HP:0003774)1.99697693
103Epistaxis (HP:0000421)1.98675240
104Patellar aplasia (HP:0006443)1.97964560
105Short ribs (HP:0000773)1.97240763
106Absent radius (HP:0003974)1.96824707
107Type 2 muscle fiber atrophy (HP:0003554)1.95637663
108Myotonia (HP:0002486)1.93552648
109Tinnitus (HP:0000360)1.91955346
110Cholelithiasis (HP:0001081)1.91879021
111Exertional dyspnea (HP:0002875)1.91521683
112Photophobia (HP:0000613)1.91206254
113Spastic tetraparesis (HP:0001285)1.89654035
114Gonadal dysgenesis (HP:0000133)1.88978368
115Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87649341
116Coronal craniosynostosis (HP:0004440)1.86224831
117Heterotopia (HP:0002282)1.84351376
118Impaired proprioception (HP:0010831)1.83609140
119Abnormality of the renal cortex (HP:0011035)1.82602634
120Flat occiput (HP:0005469)1.82403043
121Aplasia/Hypoplasia of the patella (HP:0006498)1.81820148
122Abnormal drinking behavior (HP:0030082)1.81526400
123Polydipsia (HP:0001959)1.81526400
124Absent frontal sinuses (HP:0002688)1.80763249
125Absent forearm bone (HP:0003953)1.80302850
126Aplasia involving forearm bones (HP:0009822)1.80302850
127Hyponatremia (HP:0002902)1.80105212
128Abnormality of permanent molar morphology (HP:0011071)1.79611736
129Abnormality of the dental root (HP:0006486)1.79611736
130Taurodontia (HP:0000679)1.79611736
131Neonatal respiratory distress (HP:0002643)1.78456728
132Abnormality of binocular vision (HP:0011514)1.77570257
133Diplopia (HP:0000651)1.77570257
134Renal dysplasia (HP:0000110)1.76716406
135Abnormality of dentin (HP:0010299)1.76331709
136Oculomotor apraxia (HP:0000657)1.74554273
137J-shaped sella turcica (HP:0002680)1.73722958
138Dyschromatopsia (HP:0007641)1.72544159
139Facial cleft (HP:0002006)1.69679989
140Microglossia (HP:0000171)1.69479200
141Abnormal biliary tract physiology (HP:0012439)1.68135824
142Bile duct proliferation (HP:0001408)1.68135824
143Bell-shaped thorax (HP:0001591)1.68078563
144Abnormality of molar morphology (HP:0011070)1.66845227
145Abnormality of molar (HP:0011077)1.66845227
146Absent epiphyses (HP:0010577)1.64472791
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64472791
148Abnormality of the dental pulp (HP:0006479)1.63591127
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.61953926
150Abnormality of renal excretion (HP:0011036)1.58556931
151Deformed sella turcica (HP:0002681)1.57165771
152Postaxial hand polydactyly (HP:0001162)1.56418590
153Decreased central vision (HP:0007663)1.55843556
154Short thorax (HP:0010306)1.53506312
155Choroideremia (HP:0001139)1.51373130
156Median cleft lip (HP:0000161)1.49996880
157Upper motor neuron abnormality (HP:0002127)1.49557085
158Cystic liver disease (HP:0006706)1.46686319
159Chronic sinusitis (HP:0011109)1.46596195
160Abnormality of the anterior horn cell (HP:0006802)1.42905449
161Degeneration of anterior horn cells (HP:0002398)1.42905449
162Short femoral neck (HP:0100864)1.41341024
163Broad distal phalanx of finger (HP:0009836)1.40812415
164Supernumerary spleens (HP:0009799)1.39298278
165Nephropathy (HP:0000112)1.37844817
166Pancreatic fibrosis (HP:0100732)1.36247550
167Aplasia/Hypoplasia of the tongue (HP:0010295)1.35024487
168Aplasia/Hypoplasia of the fibula (HP:0006492)1.34844346
169Abnormal urine output (HP:0012590)1.29735432
170Hemorrhage of the eye (HP:0011885)1.27770494
171Abnormality of ocular smooth pursuit (HP:0000617)1.26095643
172Aplasia/Hypoplasia of the lens (HP:0008063)1.25541601
173Pachygyria (HP:0001302)1.23606170
174Neurofibrillary tangles (HP:0002185)1.22866391
175Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.22838823
176Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.20556600
177Cerebellar dysplasia (HP:0007033)1.20174848
178Hemiparesis (HP:0001269)1.18896421
179Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.18768249
180Decreased motor nerve conduction velocity (HP:0003431)1.18727648
181Short nail (HP:0001799)1.18401250
182Bundle branch block (HP:0011710)1.16724922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.31095490
2PDK48.31095490
3TESK15.79107740
4PDK25.35655351
5PRKD34.73638400
6BLK4.47975821
7ICK4.01759472
8TXK3.35957318
9FRK2.61264709
10TLK12.60807824
11PTK2B2.54939925
12ACVR1B2.51549391
13WNK42.49186650
14STK392.40644812
15PNCK2.32884579
16ZAK2.21317419
17NEK22.01201701
18DDR21.97675250
19STK381.77899311
20PIK3CG1.77427246
21MYLK1.63881096
22GRK61.57102078
23PBK1.39521644
24BRD41.34284530
25DYRK1B1.32645143
26MAP4K21.30187485
27RPS6KA51.28959267
28SYK1.19979017
29IKBKB1.18809884
30MATK1.10927545
31MAPK151.09316282
32ADRBK11.08571628
33WNK11.05965618
34MAP3K111.03786693
35KDR1.03148476
36PDK10.99196361
37PLK20.94552281
38FES0.94512432
39TYRO30.92478177
40DYRK30.88953120
41BCKDK0.88827524
42CCNB10.88601850
43GRK10.87420763
44MAP3K120.84720615
45STK30.84671414
46SIK20.84659871
47PIM20.83892902
48PASK0.83017681
49TEC0.82570423
50TTK0.77813532
51ADRBK20.77003634
52OXSR10.72852126
53CDC70.69432489
54ARAF0.69300081
55BTK0.64032453
56WEE10.62909082
57MST1R0.61149489
58INSRR0.61000565
59PINK10.60205877
60PRKD10.60065933
61CAMK1G0.58683119
62CHEK20.58512476
63RPS6KA20.57131139
64EEF2K0.57088042
65CDK80.56109477
66ITK0.55113537
67PKN10.52514708
68IRAK10.52243655
69FGR0.50519483
70CHEK10.50477330
71PDPK10.50372203
72GRK50.49432348
73NTRK10.48680174
74TESK20.48494498
75STK38L0.47698429
76ATR0.46891326
77CDK90.45367452
78LYN0.44395807
79NTRK20.40562045
80CDK70.40493176
81TRPM70.40357979
82LMTK20.40038009
83CDK190.39805086
84GRK70.38909511
85TBK10.38225067
86ROCK10.37963851
87PAK10.36698523
88BUB10.36322553
89BMPR20.35958498
90PAK20.35737666
91MAP2K60.35410235
92ATM0.34996963
93MAPK110.34757267
94MAP2K30.34726884
95RIPK40.33965595
96MTOR0.32896729
97DYRK20.31529866
98MAPKAPK30.31378836
99ILK0.31357449
100BMPR1B0.30362461
101MUSK0.30176203
102RPS6KA60.29660716
103TRIM280.29410507
104PLK10.28672139
105DAPK30.27897286
106FLT30.27408213
107PRKCG0.27017274
108MARK20.25066525
109SGK2230.24252203
110SGK4940.24252203
111PLK40.24195584
112IRAK20.22700997
113MAPKAPK50.22525523
114PRKAA10.21491189
115CAMKK10.21246262
116BRSK20.21061297
117NEK60.19728100
118RPS6KB10.19133735
119PAK40.17303870
120CDK120.16345679
121MAP3K100.14078662
122PRKCZ0.14020391
123ZAP700.11878942
124CDK150.09564844
125BRSK10.08812032
126MAP3K40.08658199
127PRKCQ0.08495447
128CDK10.07923864
129CDK180.07127551
130MARK30.07126617
131GSK3B0.07002455
132CDK20.06964144
133CDK11A0.06812124
134CSNK2A10.06602433
135STK100.05967393
136STK110.05266359
137TAOK10.05227627
138CSNK1D0.05169158
139RPS6KA10.04652569
140PAK60.04472382
141MAPK80.03933342
142BRAF0.03682109
143MAP2K70.03644807
144PRKG10.02696121
145CSNK2A20.02399199
146CDK140.01731582
147PRKACG0.01578369
148CDK40.01438881
149PRKG20.01185104
150PRKDC0.01038563
151PRKACB0.01009924
152WNK30.00856183
153CDK60.00703662
154CSF1R0.00465852
155CDK30.00285359
156PDGFRB0.00264376
157CSK-0.0236860
158RPS6KA3-0.0221236
159MAPK10-0.0098565
160PRKCB-0.0030230
161AURKA-0.0019470
162CAMK2A-0.0003991

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006045.30836326
2Vitamin B6 metabolism_Homo sapiens_hsa007504.26193288
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.24630551
4Autoimmune thyroid disease_Homo sapiens_hsa053203.92819092
5Fatty acid biosynthesis_Homo sapiens_hsa000613.82655893
6Pyruvate metabolism_Homo sapiens_hsa006203.77150678
7Graft-versus-host disease_Homo sapiens_hsa053323.60896082
8Allograft rejection_Homo sapiens_hsa053303.40627771
9Sulfur relay system_Homo sapiens_hsa041223.38106209
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.92335554
11Propanoate metabolism_Homo sapiens_hsa006402.84361125
12Linoleic acid metabolism_Homo sapiens_hsa005912.82269604
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.77923548
14Glucagon signaling pathway_Homo sapiens_hsa049222.77522192
15Basal transcription factors_Homo sapiens_hsa030222.71619929
16Asthma_Homo sapiens_hsa053102.65708667
17Type I diabetes mellitus_Homo sapiens_hsa049402.63551888
18Dorso-ventral axis formation_Homo sapiens_hsa043202.56085727
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.38787513
20Fanconi anemia pathway_Homo sapiens_hsa034602.24642902
21Pentose phosphate pathway_Homo sapiens_hsa000302.24532092
22Selenocompound metabolism_Homo sapiens_hsa004502.23930224
23Intestinal immune network for IgA production_Homo sapiens_hsa046722.17862800
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.02504981
25Carbohydrate digestion and absorption_Homo sapiens_hsa049732.01578562
26Glycerolipid metabolism_Homo sapiens_hsa005611.96448551
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.94516731
28Oocyte meiosis_Homo sapiens_hsa041141.93231116
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.85316709
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82861659
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82119517
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79289221
33Olfactory transduction_Homo sapiens_hsa047401.68278346
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.64689254
35PPAR signaling pathway_Homo sapiens_hsa033201.64562224
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.61281880
37Amphetamine addiction_Homo sapiens_hsa050311.60869787
38Fructose and mannose metabolism_Homo sapiens_hsa000511.57331655
39Huntingtons disease_Homo sapiens_hsa050161.56639000
40Viral myocarditis_Homo sapiens_hsa054161.55065612
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.46474585
42Hematopoietic cell lineage_Homo sapiens_hsa046401.46300723
43mRNA surveillance pathway_Homo sapiens_hsa030151.40017162
44Rheumatoid arthritis_Homo sapiens_hsa053231.37827003
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37178390
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36057075
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32746818
48Carbon metabolism_Homo sapiens_hsa012001.32482735
49Fat digestion and absorption_Homo sapiens_hsa049751.32017527
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.31300064
51Ether lipid metabolism_Homo sapiens_hsa005651.28253748
52Cardiac muscle contraction_Homo sapiens_hsa042601.27327859
53Renin secretion_Homo sapiens_hsa049241.24855576
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.22015470
55RNA transport_Homo sapiens_hsa030131.21575689
56Primary immunodeficiency_Homo sapiens_hsa053401.19076880
57Phototransduction_Homo sapiens_hsa047441.17531256
58Vitamin digestion and absorption_Homo sapiens_hsa049771.16793098
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15297354
60Mineral absorption_Homo sapiens_hsa049781.15239453
61Fatty acid metabolism_Homo sapiens_hsa012121.11901585
62T cell receptor signaling pathway_Homo sapiens_hsa046601.09990787
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09354054
64NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09131276
65Antigen processing and presentation_Homo sapiens_hsa046121.08810272
66Fatty acid degradation_Homo sapiens_hsa000711.04824553
67Nicotine addiction_Homo sapiens_hsa050331.00509174
68Influenza A_Homo sapiens_hsa051641.00074225
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98809713
70Purine metabolism_Homo sapiens_hsa002300.98151968
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93850396
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92486746
73Hedgehog signaling pathway_Homo sapiens_hsa043400.88413851
74Biosynthesis of amino acids_Homo sapiens_hsa012300.86818879
75Staphylococcus aureus infection_Homo sapiens_hsa051500.85178748
76Nitrogen metabolism_Homo sapiens_hsa009100.84386893
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79144387
78Glutathione metabolism_Homo sapiens_hsa004800.78826051
79ABC transporters_Homo sapiens_hsa020100.77506109
80Long-term potentiation_Homo sapiens_hsa047200.77348187
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76420147
82Leishmaniasis_Homo sapiens_hsa051400.76265898
83Herpes simplex infection_Homo sapiens_hsa051680.75015021
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73783029
85Arachidonic acid metabolism_Homo sapiens_hsa005900.73635929
86Estrogen signaling pathway_Homo sapiens_hsa049150.72306385
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71420006
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71320832
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.69301111
90Apoptosis_Homo sapiens_hsa042100.69019062
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69010093
92Gap junction_Homo sapiens_hsa045400.68154063
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68038006
94Renin-angiotensin system_Homo sapiens_hsa046140.66569048
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66369581
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63965002
97Systemic lupus erythematosus_Homo sapiens_hsa053220.63843178
98Sphingolipid metabolism_Homo sapiens_hsa006000.62992567
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.62747356
100Circadian rhythm_Homo sapiens_hsa047100.62531243
101Toxoplasmosis_Homo sapiens_hsa051450.61419913
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60698608
103Chemical carcinogenesis_Homo sapiens_hsa052040.59424386
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.57253763
105Phagosome_Homo sapiens_hsa041450.56207204
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56171828
107Insulin secretion_Homo sapiens_hsa049110.55916684
108Calcium signaling pathway_Homo sapiens_hsa040200.55376717
109Platelet activation_Homo sapiens_hsa046110.55053661
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54607468
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54087718
112Endocytosis_Homo sapiens_hsa041440.53340438
113Regulation of autophagy_Homo sapiens_hsa041400.51705386
114AMPK signaling pathway_Homo sapiens_hsa041520.51662318
115Collecting duct acid secretion_Homo sapiens_hsa049660.51199573
116Thyroid hormone synthesis_Homo sapiens_hsa049180.50743135
117Bile secretion_Homo sapiens_hsa049760.47824327
118Legionellosis_Homo sapiens_hsa051340.45112639
119VEGF signaling pathway_Homo sapiens_hsa043700.42287285
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.42102658
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41443070
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40375832
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40117586
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39246661
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38631337
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38036170
127Morphine addiction_Homo sapiens_hsa050320.36979949
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.36759882
129Taste transduction_Homo sapiens_hsa047420.33135377
130RNA degradation_Homo sapiens_hsa030180.33112525
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32990084
132Inositol phosphate metabolism_Homo sapiens_hsa005620.32800092
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.32453523
134Pancreatic secretion_Homo sapiens_hsa049720.31944428
135Alcoholism_Homo sapiens_hsa050340.31506038
136Metabolic pathways_Homo sapiens_hsa011000.31411654
137Tuberculosis_Homo sapiens_hsa051520.31157909
138Protein digestion and absorption_Homo sapiens_hsa049740.29596624
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28941058
140Salivary secretion_Homo sapiens_hsa049700.27899782
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27731417
142Measles_Homo sapiens_hsa051620.27029564
143Pyrimidine metabolism_Homo sapiens_hsa002400.25961566
144Wnt signaling pathway_Homo sapiens_hsa043100.25526338
145Homologous recombination_Homo sapiens_hsa034400.25265128
146Basal cell carcinoma_Homo sapiens_hsa052170.25219546
147Synaptic vesicle cycle_Homo sapiens_hsa047210.25124556
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24936478
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24636943
150Lysine degradation_Homo sapiens_hsa003100.24382979
151Lysosome_Homo sapiens_hsa041420.24105601
152Chemokine signaling pathway_Homo sapiens_hsa040620.23291155
153Circadian entrainment_Homo sapiens_hsa047130.22651066
154cAMP signaling pathway_Homo sapiens_hsa040240.22592475
155N-Glycan biosynthesis_Homo sapiens_hsa005100.22140898
156Viral carcinogenesis_Homo sapiens_hsa052030.21827274
157Cell cycle_Homo sapiens_hsa041100.21213745
158mTOR signaling pathway_Homo sapiens_hsa041500.20286528
159Gastric acid secretion_Homo sapiens_hsa049710.18975902
160MAPK signaling pathway_Homo sapiens_hsa040100.18264063
161Cocaine addiction_Homo sapiens_hsa050300.17917822
162Cholinergic synapse_Homo sapiens_hsa047250.17379355
163B cell receptor signaling pathway_Homo sapiens_hsa046620.13379282
164Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12804117
165Salmonella infection_Homo sapiens_hsa051320.09848186

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