RSPH10B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.51702677
2cilium movement (GO:0003341)9.45692236
3epithelial cilium movement (GO:0003351)9.20140487
4motile cilium assembly (GO:0044458)8.14960439
5axoneme assembly (GO:0035082)7.18277125
6regulation of cilium movement (GO:0003352)7.06676038
7sperm motility (GO:0030317)6.22701075
8cilium organization (GO:0044782)4.87962513
9protein polyglutamylation (GO:0018095)4.86085267
10regulation of microtubule-based movement (GO:0060632)4.75658787
11response to pheromone (GO:0019236)4.74364017
12cilium assembly (GO:0042384)4.72742506
13multicellular organism reproduction (GO:0032504)4.71336218
14acrosome reaction (GO:0007340)4.64419582
15left/right axis specification (GO:0070986)4.60811416
16left/right pattern formation (GO:0060972)4.41815815
17intraciliary transport (GO:0042073)4.33758341
18spermatid development (GO:0007286)4.32029058
19sperm capacitation (GO:0048240)4.25807602
20behavioral response to nicotine (GO:0035095)4.25452342
21microtubule bundle formation (GO:0001578)4.19114053
22L-fucose catabolic process (GO:0042355)4.15082092
23fucose catabolic process (GO:0019317)4.15082092
24L-fucose metabolic process (GO:0042354)4.15082092
25protein localization to cilium (GO:0061512)4.00995109
26microtubule depolymerization (GO:0007019)3.96306696
27centriole assembly (GO:0098534)3.93693747
28cilium morphogenesis (GO:0060271)3.91169281
29piRNA metabolic process (GO:0034587)3.81659512
30fusion of sperm to egg plasma membrane (GO:0007342)3.79210609
31centriole replication (GO:0007099)3.77923102
32microtubule polymerization or depolymerization (GO:0031109)3.73797714
33phosphatidylethanolamine biosynthetic process (GO:0006646)3.70612455
34cellular ketone body metabolic process (GO:0046950)3.69980062
35cellular component assembly involved in morphogenesis (GO:0010927)3.67859598
36nonmotile primary cilium assembly (GO:0035058)3.66827804
37phosphatidylethanolamine metabolic process (GO:0046337)3.59410132
38reproduction (GO:0000003)3.49645425
39ventricular system development (GO:0021591)3.47859084
40sperm-egg recognition (GO:0035036)3.45364411
41ketone body metabolic process (GO:1902224)3.31082614
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.11054949
43cell projection assembly (GO:0030031)3.07924164
44one-carbon compound transport (GO:0019755)3.06806579
45photoreceptor cell maintenance (GO:0045494)3.06709607
46single fertilization (GO:0007338)3.03057343
47single strand break repair (GO:0000012)3.02830398
48plasma membrane fusion (GO:0045026)3.01129132
49establishment of protein localization to Golgi (GO:0072600)2.98044513
50cell-cell recognition (GO:0009988)2.97990598
51indole-containing compound catabolic process (GO:0042436)2.96449480
52indolalkylamine catabolic process (GO:0046218)2.96449480
53tryptophan catabolic process (GO:0006569)2.96449480
54indolalkylamine metabolic process (GO:0006586)2.94384331
55DNA methylation involved in gamete generation (GO:0043046)2.94122827
56microtubule-based movement (GO:0007018)2.91865745
57negative regulation of T cell differentiation in thymus (GO:0033085)2.89977132
58organic cation transport (GO:0015695)2.89805895
59response to xenobiotic stimulus (GO:0009410)2.88525727
60protein targeting to Golgi (GO:0000042)2.86395104
61spermatogenesis (GO:0007283)2.82073889
62smoothened signaling pathway (GO:0007224)2.81785684
63male gamete generation (GO:0048232)2.81764946
64detection of light stimulus involved in sensory perception (GO:0050962)2.81054483
65detection of light stimulus involved in visual perception (GO:0050908)2.81054483
66exogenous drug catabolic process (GO:0042738)2.77867193
67determination of left/right symmetry (GO:0007368)2.77761547
68retinal cone cell development (GO:0046549)2.77158572
69negative regulation of inclusion body assembly (GO:0090084)2.75178680
70cornea development in camera-type eye (GO:0061303)2.71716838
71male meiosis I (GO:0007141)2.71188537
72tryptophan metabolic process (GO:0006568)2.70935848
73kynurenine metabolic process (GO:0070189)2.70315068
74spinal cord motor neuron differentiation (GO:0021522)2.70216539
75rRNA methylation (GO:0031167)2.69049920
76calcium ion-dependent exocytosis (GO:0017156)2.68750889
77DNA deamination (GO:0045006)2.67833617
78rRNA catabolic process (GO:0016075)2.64016150
79seminiferous tubule development (GO:0072520)2.63607095
80gamete generation (GO:0007276)2.62548485
81protein localization to Golgi apparatus (GO:0034067)2.61472219
82microtubule severing (GO:0051013)2.60010492
83aldehyde catabolic process (GO:0046185)2.59151351
84fertilization (GO:0009566)2.58934444
85determination of bilateral symmetry (GO:0009855)2.58478578
86lateral ventricle development (GO:0021670)2.58383863
87vitamin transmembrane transport (GO:0035461)2.56274553
88preassembly of GPI anchor in ER membrane (GO:0016254)2.55901823
89rRNA modification (GO:0000154)2.51302239
90specification of symmetry (GO:0009799)2.51202426
91primary alcohol catabolic process (GO:0034310)2.49886294
92retrograde transport, vesicle recycling within Golgi (GO:0000301)2.47336321
93regulation of action potential (GO:0098900)2.47256975
94drug catabolic process (GO:0042737)2.46112025
95ubiquinone biosynthetic process (GO:0006744)2.46036499
96negative regulation of telomere maintenance (GO:0032205)2.45936889
97nephron epithelium morphogenesis (GO:0072088)2.43425048
98nephron tubule morphogenesis (GO:0072078)2.43425048
99axonemal dynein complex assembly (GO:0070286)11.8924838
100cilium or flagellum-dependent cell motility (GO:0001539)10.2768092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.37156145
2VDR_22108803_ChIP-Seq_LS180_Human3.27249735
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.81902978
4GBX2_23144817_ChIP-Seq_PC3_Human2.41980500
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38211180
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18941518
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18767060
8EZH2_22144423_ChIP-Seq_EOC_Human2.18241120
9EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.07401528
10FUS_26573619_Chip-Seq_HEK293_Human1.95741123
11ER_23166858_ChIP-Seq_MCF-7_Human1.95324932
12CBP_20019798_ChIP-Seq_JUKART_Human1.85742511
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.85742511
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83114991
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78222419
16TAF15_26573619_Chip-Seq_HEK293_Human1.74611281
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.72804753
18P300_19829295_ChIP-Seq_ESCs_Human1.70606476
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70094011
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69658396
21TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68953305
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.68953305
23DROSHA_22980978_ChIP-Seq_HELA_Human1.68512690
24IGF1R_20145208_ChIP-Seq_DFB_Human1.67768213
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49610038
26SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47924573
27FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47595622
28FOXA1_25329375_ChIP-Seq_VCAP_Human1.47595622
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47010056
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46601648
31GATA3_21878914_ChIP-Seq_MCF-7_Human1.46016400
32AR_25329375_ChIP-Seq_VCAP_Human1.45891465
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.45121326
34BCAT_22108803_ChIP-Seq_LS180_Human1.45016766
35SMAD4_21799915_ChIP-Seq_A2780_Human1.44305567
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.43841989
37STAT3_23295773_ChIP-Seq_U87_Human1.43785899
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43123318
39EWS_26573619_Chip-Seq_HEK293_Human1.41584239
40ERA_21632823_ChIP-Seq_H3396_Human1.41127937
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.40938923
42NCOR_22424771_ChIP-Seq_293T_Human1.39614310
43ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39542016
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38849120
45IRF1_19129219_ChIP-ChIP_H3396_Human1.38267653
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37285273
47TP53_22573176_ChIP-Seq_HFKS_Human1.35709170
48MYC_19829295_ChIP-Seq_ESCs_Human1.32938150
49SOX2_19829295_ChIP-Seq_ESCs_Human1.31788389
50NANOG_19829295_ChIP-Seq_ESCs_Human1.31788389
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.31219825
52NANOG_20526341_ChIP-Seq_ESCs_Human1.30621392
53TCF4_23295773_ChIP-Seq_U87_Human1.30238550
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29888354
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28899517
56TCF4_22108803_ChIP-Seq_LS180_Human1.28418274
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27607321
58ETV1_20927104_ChIP-Seq_GIST48_Human1.26700746
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26383116
60REST_21632747_ChIP-Seq_MESCs_Mouse1.25781093
61RUNX2_22187159_ChIP-Seq_PCA_Human1.23579751
62TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23126277
63TAF2_19829295_ChIP-Seq_ESCs_Human1.22838324
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22715788
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22348678
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21654142
67PHF8_20622853_ChIP-Seq_HELA_Human1.21595206
68HOXB7_26014856_ChIP-Seq_BT474_Human1.21473264
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20041703
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.19536756
71AR_20517297_ChIP-Seq_VCAP_Human1.17793864
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17774482
73RBPJ_21746931_ChIP-Seq_IB4_Human1.17675602
74AR_21572438_ChIP-Seq_LNCaP_Human1.16551646
75OCT4_20526341_ChIP-Seq_ESCs_Human1.15445465
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15208914
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14994593
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14542570
79AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12771543
80SMRT_27268052_Chip-Seq_Bcells_Human1.12468438
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11637846
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11417114
83WDR5_24793694_ChIP-Seq_LNCAP_Human1.10844171
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10604403
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10569152
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10258612
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09812593
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09653478
89CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09161914
90HNFA_21074721_ChIP-Seq_CACO-2_Human1.08477353
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08211865
92NFYB_21822215_ChIP-Seq_K562_Human1.07169329
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.06981888
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06628464
95TBL1_22424771_ChIP-Seq_293T_Human1.06360698
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06322245
97CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05967356
98CDX2_22108803_ChIP-Seq_LS180_Human1.04531554
99MYC_18940864_ChIP-ChIP_HL60_Human1.04264871
100CEBPB_22108803_ChIP-Seq_LS180_Human1.03836646

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.85339412
2MP0008875_abnormal_xenobiotic_pharmacok3.68994276
3MP0002653_abnormal_ependyma_morphology3.47451849
4MP0001984_abnormal_olfaction2.70787879
5MP0003878_abnormal_ear_physiology2.58764383
6MP0005377_hearing/vestibular/ear_phenot2.58764383
7MP0002102_abnormal_ear_morphology2.54720190
8MP0004043_abnormal_pH_regulation2.41845045
9MP0005551_abnormal_eye_electrophysiolog2.27605104
10MP0004133_heterotaxia2.14514130
11MP0002876_abnormal_thyroid_physiology2.10199905
12MP0003011_delayed_dark_adaptation2.09764444
13MP0008877_abnormal_DNA_methylation2.08065548
14MP0001968_abnormal_touch/_nociception2.07629585
15MP0003698_abnormal_male_reproductive2.05956659
16MP0001986_abnormal_taste_sensitivity1.96467410
17MP0005646_abnormal_pituitary_gland1.94876939
18MP0002277_abnormal_respiratory_mucosa1.94673551
19MP0001929_abnormal_gametogenesis1.94598338
20MP0008789_abnormal_olfactory_epithelium1.81195389
21MP0005253_abnormal_eye_physiology1.79397121
22MP0002638_abnormal_pupillary_reflex1.66143241
23MP0003195_calcinosis1.64390543
24MP0001485_abnormal_pinna_reflex1.57134070
25MP0009046_muscle_twitch1.56580327
26MP0009745_abnormal_behavioral_response1.56169982
27MP0003718_maternal_effect1.56161557
28MP0002735_abnormal_chemical_nociception1.55981217
29MP0002282_abnormal_trachea_morphology1.55650458
30MP0001486_abnormal_startle_reflex1.53646481
31MP0008872_abnormal_physiological_respon1.53632875
32MP0003136_yellow_coat_color1.53352936
33MP0006292_abnormal_olfactory_placode1.50252042
34MP0006072_abnormal_retinal_apoptosis1.47846905
35MP0002272_abnormal_nervous_system1.44797112
36MP0003880_abnormal_central_pattern1.43944290
37MP0002736_abnormal_nociception_after1.43078790
38MP0006276_abnormal_autonomic_nervous1.41456273
39MP0001529_abnormal_vocalization1.41126339
40MP0002132_abnormal_respiratory_system1.40257151
41MP0002160_abnormal_reproductive_system1.39267503
42MP0003646_muscle_fatigue1.38117329
43MP0004142_abnormal_muscle_tone1.35955290
44MP0002138_abnormal_hepatobiliary_system1.34063175
45MP0005645_abnormal_hypothalamus_physiol1.33502721
46MP0005084_abnormal_gallbladder_morpholo1.32680155
47MP0009780_abnormal_chondrocyte_physiolo1.30610255
48MP0002928_abnormal_bile_duct1.28083379
49MP0001501_abnormal_sleep_pattern1.28045580
50MP0002734_abnormal_mechanical_nocicepti1.23838211
51MP0001765_abnormal_ion_homeostasis1.20789023
52MP0005499_abnormal_olfactory_system1.18972947
53MP0005394_taste/olfaction_phenotype1.18972947
54MP0002210_abnormal_sex_determination1.17895380
55MP0001970_abnormal_pain_threshold1.16810784
56MP0005423_abnormal_somatic_nervous1.16468412
57MP0002837_dystrophic_cardiac_calcinosis1.16006906
58MP0000427_abnormal_hair_cycle1.15947764
59MP0000372_irregular_coat_pigmentation1.14849104
60MP0000631_abnormal_neuroendocrine_gland1.14684903
61MP0000383_abnormal_hair_follicle1.13345591
62MP0005389_reproductive_system_phenotype1.12271454
63MP0004885_abnormal_endolymph1.11369864
64MP0002557_abnormal_social/conspecific_i1.10901997
65MP0002234_abnormal_pharynx_morphology1.09419411
66MP0002572_abnormal_emotion/affect_behav1.09368466
67MP0001905_abnormal_dopamine_level1.07219578
68MP0001502_abnormal_circadian_rhythm1.05731034
69MP0000026_abnormal_inner_ear1.05652594
70MP0002161_abnormal_fertility/fecundity1.03065292
71MP0000653_abnormal_sex_gland1.00433760
72MP0002229_neurodegeneration1.00079937
73MP0002733_abnormal_thermal_nociception0.99446735
74MP0005379_endocrine/exocrine_gland_phen0.99270540
75MP0008995_early_reproductive_senescence0.98412894
76MP0001963_abnormal_hearing_physiology0.98092874
77MP0010386_abnormal_urinary_bladder0.97538222
78MP0002067_abnormal_sensory_capabilities0.96265451
79MP0005636_abnormal_mineral_homeostasis0.95450428
80MP0001145_abnormal_male_reproductive0.94487949
81MP0004019_abnormal_vitamin_homeostasis0.94095839
82MP0003787_abnormal_imprinting0.93621762
83MP0005195_abnormal_posterior_eye0.91616043
84MP0004742_abnormal_vestibular_system0.87055152
85MP0000613_abnormal_salivary_gland0.85186932
86MP0005395_other_phenotype0.84374743
87MP0004924_abnormal_behavior0.83205215
88MP0005386_behavior/neurological_phenoty0.83205215
89MP0001293_anophthalmia0.83089846
90MP0001324_abnormal_eye_pigmentation0.83010338
91MP0002752_abnormal_somatic_nervous0.80337073
92MP0002064_seizures0.79675100
93MP0005391_vision/eye_phenotype0.78672547
94MP0005083_abnormal_biliary_tract0.78302619
95MP0008775_abnormal_heart_ventricle0.74021506
96MP0002063_abnormal_learning/memory/cond0.70462187
97MP0002693_abnormal_pancreas_physiology0.68451875
98MP0001919_abnormal_reproductive_system0.68391328
99MP0003252_abnormal_bile_duct0.67585932
100MP0004085_abnormal_heartbeat0.67200448

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.44171700
2Absent/shortened dynein arms (HP:0200106)8.44171700
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.15805077
4Abnormal respiratory epithelium morphology (HP:0012253)8.05386247
5Abnormal respiratory motile cilium morphology (HP:0005938)8.05386247
6Abnormal ciliary motility (HP:0012262)7.82959829
7Abnormal respiratory motile cilium physiology (HP:0012261)7.65418776
8Rhinitis (HP:0012384)6.53534493
9Chronic bronchitis (HP:0004469)4.81496728
10Bronchiectasis (HP:0002110)4.73163392
11Pancreatic fibrosis (HP:0100732)4.62493261
12True hermaphroditism (HP:0010459)4.50498120
13Molar tooth sign on MRI (HP:0002419)4.41362186
14Abnormality of midbrain morphology (HP:0002418)4.41362186
15Pancreatic cysts (HP:0001737)4.35069421
16Nephronophthisis (HP:0000090)4.18101790
17Chronic hepatic failure (HP:0100626)4.16845886
18Nasal polyposis (HP:0100582)4.00024581
19Abnormality of the renal medulla (HP:0100957)3.50033382
20Cystic liver disease (HP:0006706)3.35923645
21Infertility (HP:0000789)3.30520675
22Occipital encephalocele (HP:0002085)3.26727818
23Abnormality of the nasal mucosa (HP:0000433)3.11210367
24Medial flaring of the eyebrow (HP:0010747)2.96569568
25Abnormal rod and cone electroretinograms (HP:0008323)2.95920503
26Chronic sinusitis (HP:0011109)2.86159338
27Tubular atrophy (HP:0000092)2.83425409
28Tubulointerstitial nephritis (HP:0001970)2.78747911
29Recurrent sinusitis (HP:0011108)2.71905856
30Abnormality of the renal cortex (HP:0011035)2.70858122
31Attenuation of retinal blood vessels (HP:0007843)2.67776092
32Polydipsia (HP:0001959)2.67369462
33Abnormal drinking behavior (HP:0030082)2.67369462
34Sclerocornea (HP:0000647)2.66184365
35Postaxial foot polydactyly (HP:0001830)2.63557514
36Bronchitis (HP:0012387)2.63217518
37Type II lissencephaly (HP:0007260)2.62092512
38Congenital hepatic fibrosis (HP:0002612)2.55964082
39Decreased central vision (HP:0007663)2.50938318
40Anencephaly (HP:0002323)2.48799651
41Bony spicule pigmentary retinopathy (HP:0007737)2.45187426
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42425743
43Male pseudohermaphroditism (HP:0000037)2.38704170
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.37165880
45Gait imbalance (HP:0002141)2.36748670
46Congenital stationary night blindness (HP:0007642)2.34647569
47Congenital primary aphakia (HP:0007707)2.32363798
48Abnormality of macular pigmentation (HP:0008002)2.31055826
49Male infertility (HP:0003251)2.30232345
50Aplasia/Hypoplasia of the spleen (HP:0010451)2.16269349
51Polyuria (HP:0000103)2.12396077
52Severe visual impairment (HP:0001141)2.09289943
53Decreased circulating renin level (HP:0003351)2.08835607
54Nephrogenic diabetes insipidus (HP:0009806)2.08485605
55Abnormal biliary tract physiology (HP:0012439)2.08156105
56Bile duct proliferation (HP:0001408)2.08156105
57Tubulointerstitial abnormality (HP:0001969)2.03334369
58Pendular nystagmus (HP:0012043)2.02933331
59Asplenia (HP:0001746)2.02769641
60Furrowed tongue (HP:0000221)2.01334745
61Abolished electroretinogram (ERG) (HP:0000550)1.96750027
62Postaxial hand polydactyly (HP:0001162)1.95993139
63Oculomotor apraxia (HP:0000657)1.93764281
64Cerebellar dysplasia (HP:0007033)1.93347361
65Hyperkalemia (HP:0002153)1.92467357
66Recurrent otitis media (HP:0000403)1.92211638
67Abnormal urine output (HP:0012590)1.81791737
68Genital tract atresia (HP:0001827)1.79444585
69Cone-rod dystrophy (HP:0000548)1.79099022
70Vaginal atresia (HP:0000148)1.73358505
71Abnormality of renal excretion (HP:0011036)1.68255854
72Preaxial hand polydactyly (HP:0001177)1.67276284
73Keratoconus (HP:0000563)1.66496030
74Increased corneal curvature (HP:0100692)1.66496030
75Poor coordination (HP:0002370)1.66207020
76Hyperactive renin-angiotensin system (HP:0000841)1.64416477
77Retinitis pigmentosa (HP:0000510)1.64087741
78Chronic otitis media (HP:0000389)1.60918800
79Stage 5 chronic kidney disease (HP:0003774)1.60167381
80Median cleft lip (HP:0000161)1.58014184
81Progressive cerebellar ataxia (HP:0002073)1.57905831
82Nephropathy (HP:0000112)1.53579666
83Renal cortical cysts (HP:0000803)1.52153312
84Tubulointerstitial fibrosis (HP:0005576)1.51812163
85Retinal dysplasia (HP:0007973)1.48844783
86Narrow forehead (HP:0000341)1.47887763
87Supernumerary spleens (HP:0009799)1.43519201
88Renal salt wasting (HP:0000127)1.43381935
89Aganglionic megacolon (HP:0002251)1.43017041
90Absent speech (HP:0001344)1.42236752
91Macular degeneration (HP:0000608)1.42030524
92Multicystic kidney dysplasia (HP:0000003)1.41951983
93Abnormality of renin-angiotensin system (HP:0000847)1.41231727
94Hypomagnesemia (HP:0002917)1.40937401
95Disproportionate short-trunk short stature (HP:0003521)1.38517513
96Lissencephaly (HP:0001339)1.38031560
97Prominent nasal bridge (HP:0000426)1.37889349
98Azoospermia (HP:0000027)1.35582028
99Abnormality of dental color (HP:0011073)1.33759269
100Optic nerve hypoplasia (HP:0000609)1.33400589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.71142837
2FRK3.97136974
3MAP4K23.40486964
4ADRBK22.89859617
5WNK42.79450709
6ZAK2.68757642
7TLK12.46151822
8PNCK2.40660451
9BMPR1B2.32348160
10INSRR2.27608304
11PINK12.23866173
12PLK42.23734424
13GRK12.22368708
14MST42.17559371
15WNK32.11628522
16TAOK32.02398983
17STK161.76751075
18OXSR11.53778991
19PLK21.51943422
20MAPK131.49740609
21NUAK11.44267963
22BCR1.32875685
23STK391.31834875
24MAP3K41.29139469
25MAPKAPK31.25951352
26PTK2B1.25884581
27CASK1.23344370
28STK38L1.21824882
29ACVR1B1.09693378
30TXK1.08079308
31NME11.01115930
32TRIM280.98044014
33TSSK60.97661489
34BRSK20.97630747
35STK380.97460227
36CAMKK20.93158993
37DYRK20.89374303
38TIE10.85634611
39PHKG10.84692026
40PHKG20.84692026
41DAPK20.82710219
42ADRBK10.82100076
43PAK30.82074680
44MUSK0.80126785
45PRKCG0.74932946
46CSNK1G20.71601199
47PRKCQ0.71107395
48PRKCI0.70932351
49VRK10.70355688
50PRKCE0.70011465
51CDK190.66597433
52MKNK20.64699463
53TNIK0.64291077
54FER0.62799585
55ERBB30.62446109
56MAP2K60.61494752
57NTRK30.59908348
58MAP2K70.59324931
59CSNK1G30.57949515
60EPHA40.57791135
61CSNK1G10.56239047
62WNK10.52682461
63MARK10.52593447
64BCKDK0.52146193
65KIT0.51550484
66MAPKAPK50.51030618
67EPHA20.47571949
68TEC0.46761498
69PRKACA0.46026469
70CSNK1A1L0.45888426
71TGFBR10.45421133
72NEK60.43601114
73CDK30.42605044
74PLK30.42580966
75IKBKB0.40268649
76CAMK2A0.40230485
77PRKD30.39764635
78WEE10.39495224
79PRKG10.38359183
80CHUK0.37937096
81EIF2AK30.37711294
82STK240.36897337
83DYRK1B0.36717077
84PRKCA0.36431907
85CAMK1G0.36419785
86CSNK1A10.35985084
87PRKAA20.35839807
88PLK10.35524799
89MAP3K70.35239760
90IRAK10.34720786
91MAP2K20.33891355
92DYRK30.33367903
93PRKCZ0.32765565
94CAMK10.32575773
95PIK3CA0.32172825
96ITK0.31793714
97TRPM70.30031750
98STK110.29203417
99DYRK1A0.28283981
100RPS6KA50.28151318

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.11657751
2Linoleic acid metabolism_Homo sapiens_hsa005912.82365201
3Caffeine metabolism_Homo sapiens_hsa002322.62091032
4Phototransduction_Homo sapiens_hsa047442.54159889
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30147614
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26000777
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24607032
8Butanoate metabolism_Homo sapiens_hsa006502.23615155
9Nitrogen metabolism_Homo sapiens_hsa009102.21892411
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.17941041
11Chemical carcinogenesis_Homo sapiens_hsa052042.13031189
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.06787133
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96163518
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87901116
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.78167335
16Olfactory transduction_Homo sapiens_hsa047401.74792756
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74439652
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73497671
19Huntingtons disease_Homo sapiens_hsa050161.72168058
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67132751
21Nicotine addiction_Homo sapiens_hsa050331.63872932
22Ether lipid metabolism_Homo sapiens_hsa005651.55292397
23Tryptophan metabolism_Homo sapiens_hsa003801.52139340
24Oxidative phosphorylation_Homo sapiens_hsa001901.48864664
25Retinol metabolism_Homo sapiens_hsa008301.48486458
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.45214590
27ABC transporters_Homo sapiens_hsa020101.42061300
28Taste transduction_Homo sapiens_hsa047421.40071335
29Peroxisome_Homo sapiens_hsa041461.38191803
30Basal transcription factors_Homo sapiens_hsa030221.38098159
31Selenocompound metabolism_Homo sapiens_hsa004501.37923695
32beta-Alanine metabolism_Homo sapiens_hsa004101.36387157
33Histidine metabolism_Homo sapiens_hsa003401.36221460
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35939796
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.31986018
36Fatty acid biosynthesis_Homo sapiens_hsa000611.31888351
37Type I diabetes mellitus_Homo sapiens_hsa049401.27463602
38Arachidonic acid metabolism_Homo sapiens_hsa005901.19273863
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19139077
40Tyrosine metabolism_Homo sapiens_hsa003501.18361534
41Allograft rejection_Homo sapiens_hsa053301.17666795
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16607062
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.16336526
44Phenylalanine metabolism_Homo sapiens_hsa003601.15276313
45Asthma_Homo sapiens_hsa053101.14393063
46RNA polymerase_Homo sapiens_hsa030201.13460736
47Fatty acid degradation_Homo sapiens_hsa000711.11241586
48Fanconi anemia pathway_Homo sapiens_hsa034601.10479210
49Autoimmune thyroid disease_Homo sapiens_hsa053201.06906723
50Protein export_Homo sapiens_hsa030601.01376950
51Regulation of autophagy_Homo sapiens_hsa041400.98480488
52Propanoate metabolism_Homo sapiens_hsa006400.96878833
53Cardiac muscle contraction_Homo sapiens_hsa042600.96454782
54Salivary secretion_Homo sapiens_hsa049700.94988274
55Graft-versus-host disease_Homo sapiens_hsa053320.94276467
56Circadian rhythm_Homo sapiens_hsa047100.90406654
57Parkinsons disease_Homo sapiens_hsa050120.89836461
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89579278
59RNA degradation_Homo sapiens_hsa030180.85219746
60Dorso-ventral axis formation_Homo sapiens_hsa043200.83527255
61Serotonergic synapse_Homo sapiens_hsa047260.77304275
62Morphine addiction_Homo sapiens_hsa050320.75464331
63Insulin secretion_Homo sapiens_hsa049110.74240536
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73778741
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.70830131
66Purine metabolism_Homo sapiens_hsa002300.69328282
67Fat digestion and absorption_Homo sapiens_hsa049750.66926668
68Homologous recombination_Homo sapiens_hsa034400.66886983
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65305775
70Collecting duct acid secretion_Homo sapiens_hsa049660.65195898
71Metabolic pathways_Homo sapiens_hsa011000.64498168
72Hedgehog signaling pathway_Homo sapiens_hsa043400.62981866
73Glutathione metabolism_Homo sapiens_hsa004800.60591841
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57336803
75Circadian entrainment_Homo sapiens_hsa047130.56649846
76Glutamatergic synapse_Homo sapiens_hsa047240.56250454
77Alzheimers disease_Homo sapiens_hsa050100.55666446
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54041939
79GABAergic synapse_Homo sapiens_hsa047270.52068629
80Ovarian steroidogenesis_Homo sapiens_hsa049130.50892532
81Calcium signaling pathway_Homo sapiens_hsa040200.49837417
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49106810
83Glycerolipid metabolism_Homo sapiens_hsa005610.49043026
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48658308
85Steroid biosynthesis_Homo sapiens_hsa001000.48523801
86Antigen processing and presentation_Homo sapiens_hsa046120.46749673
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44717352
88Fatty acid metabolism_Homo sapiens_hsa012120.43917582
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41831291
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41607895
91One carbon pool by folate_Homo sapiens_hsa006700.41021786
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40233010
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39599696
94Proteasome_Homo sapiens_hsa030500.39545568
95Arginine and proline metabolism_Homo sapiens_hsa003300.38618161
96Primary immunodeficiency_Homo sapiens_hsa053400.37718374
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35058138
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35053749
99cAMP signaling pathway_Homo sapiens_hsa040240.34016715
100Sphingolipid metabolism_Homo sapiens_hsa006000.33168015

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