RSC1A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this intronless gene inhibits the expression of the solute carrier family 5 (sodium/glucose cotransporter), member 1 gene (SLC5A1) and downregulates exocytosis of the SLC5A1 protein. The encoded protein is sometimes found coating the trans-Golgi network and other times is localized to the nucleus, depending on the cell cycle stage. This protein also inhibits the expression of solute carrier family 22 (organic cation transporter), member 2 (SLC22A2). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.51714157
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.91581030
3L-phenylalanine catabolic process (GO:0006559)6.91581030
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.58588372
5L-phenylalanine metabolic process (GO:0006558)6.58588372
6aromatic amino acid family catabolic process (GO:0009074)6.38817699
7nuclear pore organization (GO:0006999)6.38271074
8tryptophan catabolic process (GO:0006569)6.00185991
9indole-containing compound catabolic process (GO:0042436)6.00185991
10indolalkylamine catabolic process (GO:0046218)6.00185991
11regulation of RNA export from nucleus (GO:0046831)5.91073471
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.82701280
13kynurenine metabolic process (GO:0070189)5.80377883
14tryptophan metabolic process (GO:0006568)5.69050081
15glyoxylate metabolic process (GO:0046487)5.53551158
16urea metabolic process (GO:0019627)5.50628444
17urea cycle (GO:0000050)5.50628444
18pore complex assembly (GO:0046931)5.50340679
19bile acid biosynthetic process (GO:0006699)5.48899341
20cysteine metabolic process (GO:0006534)5.40575962
21serine family amino acid catabolic process (GO:0009071)5.37009424
22alpha-linolenic acid metabolic process (GO:0036109)5.20178535
23negative regulation of fibrinolysis (GO:0051918)5.14426154
24glycine metabolic process (GO:0006544)5.11466869
25nitrogen cycle metabolic process (GO:0071941)5.06569281
26high-density lipoprotein particle remodeling (GO:0034375)5.03553476
27regulation of protein activation cascade (GO:2000257)5.01625281
28protein carboxylation (GO:0018214)4.98494599
29peptidyl-glutamic acid carboxylation (GO:0017187)4.98494599
30regulation of fibrinolysis (GO:0051917)4.91130421
31sulfur amino acid catabolic process (GO:0000098)4.83706665
32complement activation, alternative pathway (GO:0006957)4.83470656
33regulation of nucleobase-containing compound transport (GO:0032239)4.77354389
34aromatic amino acid family metabolic process (GO:0009072)4.76366139
35mitotic chromosome condensation (GO:0007076)4.76261505
36bile acid metabolic process (GO:0008206)4.73139999
37serine family amino acid biosynthetic process (GO:0009070)4.72131388
38regulation of complement activation (GO:0030449)4.66159256
39serine family amino acid metabolic process (GO:0009069)4.63630918
40amino-acid betaine metabolic process (GO:0006577)4.62982625
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.59313948
42homocysteine metabolic process (GO:0050667)4.52932962
43regulation of triglyceride catabolic process (GO:0010896)4.50842572
44cellular biogenic amine catabolic process (GO:0042402)4.45583058
45amine catabolic process (GO:0009310)4.45583058
46acylglycerol homeostasis (GO:0055090)4.44774865
47triglyceride homeostasis (GO:0070328)4.44774865
48mitotic sister chromatid cohesion (GO:0007064)4.43816468
49alpha-amino acid catabolic process (GO:1901606)4.39598012
50reverse cholesterol transport (GO:0043691)4.35046038
51lysine metabolic process (GO:0006553)4.33151431
52lysine catabolic process (GO:0006554)4.33151431
53tyrosine metabolic process (GO:0006570)4.32227633
54negative regulation of sterol transport (GO:0032372)4.29314630
55negative regulation of cholesterol transport (GO:0032375)4.29314630
56indolalkylamine metabolic process (GO:0006586)4.28373701
57protein-lipid complex remodeling (GO:0034368)4.27233838
58macromolecular complex remodeling (GO:0034367)4.27233838
59plasma lipoprotein particle remodeling (GO:0034369)4.27233838
60imidazole-containing compound metabolic process (GO:0052803)4.24663027
61regulation of cholesterol esterification (GO:0010872)4.21903076
62negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.14857043
63bile acid and bile salt transport (GO:0015721)4.13626408
64phospholipid efflux (GO:0033700)4.10671450
65arginine metabolic process (GO:0006525)4.03473931
66COPII vesicle coating (GO:0048208)4.00097431
67plasma lipoprotein particle clearance (GO:0034381)3.99964801
68cellular amino acid catabolic process (GO:0009063)3.97879422
69cellular ketone body metabolic process (GO:0046950)3.91133625
70L-serine metabolic process (GO:0006563)3.87267189
71cellular glucuronidation (GO:0052695)3.85879098
72coenzyme catabolic process (GO:0009109)3.84846096
73aldehyde catabolic process (GO:0046185)3.82867587
74complement activation, classical pathway (GO:0006958)3.81317110
75one-carbon metabolic process (GO:0006730)3.79929086
76fibrinolysis (GO:0042730)3.79114923
77folic acid metabolic process (GO:0046655)3.77752135
78negative regulation of DNA repair (GO:0045738)3.77507225
79benzene-containing compound metabolic process (GO:0042537)3.76742210
80ethanol oxidation (GO:0006069)3.76675699
81synapsis (GO:0007129)3.76449953
82cholesterol efflux (GO:0033344)3.75888537
83positive regulation of triglyceride lipase activity (GO:0061365)3.68545734
84positive regulation of lipoprotein lipase activity (GO:0051006)3.68545734
85regulation of activation of Janus kinase activity (GO:0010533)3.68065872
86sister chromatid segregation (GO:0000819)3.66832601
87mitotic nuclear envelope disassembly (GO:0007077)3.66557398
88response to UV-C (GO:0010225)3.65878809
89regulation of retinoic acid receptor signaling pathway (GO:0048385)3.65690704
90pyridine nucleotide biosynthetic process (GO:0019363)3.65065313
91nicotinamide nucleotide biosynthetic process (GO:0019359)3.65065313
92complement activation (GO:0006956)3.64326440
93glutamate metabolic process (GO:0006536)3.63750719
94growth hormone receptor signaling pathway (GO:0060396)3.61519931
95regulation of histone H3-K9 methylation (GO:0051570)3.60881861
96cellular modified amino acid catabolic process (GO:0042219)3.59044779
97NAD biosynthetic process (GO:0009435)3.57713186
98regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57409470
99mitotic sister chromatid segregation (GO:0000070)3.56966351
100Golgi transport vesicle coating (GO:0048200)3.55160384
101COPI coating of Golgi vesicle (GO:0048205)3.55160384
102urate metabolic process (GO:0046415)3.53139065
103membrane disassembly (GO:0030397)3.51944061
104nuclear envelope disassembly (GO:0051081)3.51944061
105DNA topological change (GO:0006265)3.51197915
106mitotic G2/M transition checkpoint (GO:0044818)3.50541232
107cofactor catabolic process (GO:0051187)3.50452003
108protein activation cascade (GO:0072376)3.50408805
109drug catabolic process (GO:0042737)3.50117312
110plasma lipoprotein particle assembly (GO:0034377)3.48943967
111regulation of cholesterol homeostasis (GO:2000188)3.48924544
112blood coagulation, intrinsic pathway (GO:0007597)3.47816151
113heme transport (GO:0015886)3.47397240
114cholesterol homeostasis (GO:0042632)3.45538917
115DNA unwinding involved in DNA replication (GO:0006268)3.44517089
116mitotic metaphase plate congression (GO:0007080)3.44475026
117dicarboxylic acid biosynthetic process (GO:0043650)3.42031056
118organic acid catabolic process (GO:0016054)3.41969476
119carboxylic acid catabolic process (GO:0046395)3.41969476
120regulation of bile acid biosynthetic process (GO:0070857)3.41926330
121sterol homeostasis (GO:0055092)3.41461620
122protoporphyrinogen IX metabolic process (GO:0046501)3.41432929
123carnitine metabolic process (GO:0009437)3.41205438
124DNA synthesis involved in DNA repair (GO:0000731)3.40960520
125meiotic chromosome segregation (GO:0045132)3.40060428
126glucuronate metabolic process (GO:0019585)3.38678844
127uronic acid metabolic process (GO:0006063)3.38678844
128low-density lipoprotein particle remodeling (GO:0034374)3.38291555
129ribosome assembly (GO:0042255)3.36988430
130acetyl-CoA metabolic process (GO:0006084)3.35373796
131ketone body metabolic process (GO:1902224)3.33869517
132mitotic G2 DNA damage checkpoint (GO:0007095)3.33188601
133phospholipid homeostasis (GO:0055091)3.31114601
134regulation of DNA endoreduplication (GO:0032875)3.30957788
135DNA methylation involved in gamete generation (GO:0043046)3.28153905
136protein localization to chromosome, centromeric region (GO:0071459)3.26582756
137piRNA metabolic process (GO:0034587)3.21331579
138definitive hemopoiesis (GO:0060216)3.18122462
139cellular response to growth hormone stimulus (GO:0071378)3.17632720
140positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03974967
141positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03974967
142positive regulation of mitotic sister chromatid separation (GO:1901970)3.03974967
143metaphase plate congression (GO:0051310)3.02782722
144monoubiquitinated protein deubiquitination (GO:0035520)3.01038113
145N-terminal protein amino acid acetylation (GO:0006474)3.00403676
146erythrocyte maturation (GO:0043249)2.96544402
147regulation of transforming growth factor beta2 production (GO:0032909)2.96467011
148regulation of histone H3-K27 methylation (GO:0061085)2.96207596
149histone H3-K36 demethylation (GO:0070544)2.95024606
150DNA replication checkpoint (GO:0000076)2.94623802
151resolution of meiotic recombination intermediates (GO:0000712)2.94298545
152regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.91742587
153regulation of histone methylation (GO:0031060)2.91665834
154CENP-A containing nucleosome assembly (GO:0034080)2.84628460
155sister chromatid cohesion (GO:0007062)2.82177255
156male meiosis I (GO:0007141)2.81458953
157regulation of centriole replication (GO:0046599)2.80125481
158intra-S DNA damage checkpoint (GO:0031573)2.79526287
159negative regulation of histone methylation (GO:0031061)2.77552871
160positive regulation of chromosome segregation (GO:0051984)2.76528553
161positive regulation of DNA-dependent DNA replication (GO:2000105)2.74411719
162gene silencing by RNA (GO:0031047)2.74270215
163nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.74221411
164DNA replication initiation (GO:0006270)2.73495927
165chromosome segregation (GO:0007059)2.72642080
166DNA duplex unwinding (GO:0032508)2.71352908
167establishment of chromosome localization (GO:0051303)2.68464040
168protein localization to chromosome (GO:0034502)2.67688762
169folic acid-containing compound biosynthetic process (GO:0009396)2.67636203
170regulation of mitotic spindle organization (GO:0060236)2.66449667
171regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.65148174
172regulation of mitotic metaphase/anaphase transition (GO:0030071)2.65148174
173protein localization to kinetochore (GO:0034501)2.65143310
174regulation of chromosome segregation (GO:0051983)2.62793833
175DNA geometric change (GO:0032392)2.61188375
176positive regulation of mRNA 3-end processing (GO:0031442)2.60633921
177mitotic spindle checkpoint (GO:0071174)2.59044175
178DNA conformation change (GO:0071103)2.58880560
179glucocorticoid receptor signaling pathway (GO:0042921)2.58829816
180DNA packaging (GO:0006323)2.58100159
181regulation of histone H3-K4 methylation (GO:0051569)2.57702323
182regulation of sister chromatid cohesion (GO:0007063)2.57681678
183spliceosomal tri-snRNP complex assembly (GO:0000244)2.57550953
184negative regulation of chromosome segregation (GO:0051985)2.57104675
185regulation of sister chromatid segregation (GO:0033045)2.57009132
186regulation of mitotic sister chromatid separation (GO:0010965)2.57009132
187regulation of mitotic sister chromatid segregation (GO:0033047)2.57009132
188protoporphyrinogen IX biosynthetic process (GO:0006782)2.56674079
189chromosome condensation (GO:0030261)2.55620726
190embryonic process involved in female pregnancy (GO:0060136)2.54941053
191chromatin remodeling at centromere (GO:0031055)2.54921747
192regulation of mRNA 3-end processing (GO:0031440)2.53796539
193sphingomyelin metabolic process (GO:0006684)2.52386484
194histone H3-K9 demethylation (GO:0033169)2.51544862
195spindle checkpoint (GO:0031577)2.51139810
196histone exchange (GO:0043486)2.50144362
197negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.50011811
198negative regulation of mitotic sister chromatid segregation (GO:0033048)2.50011811
199negative regulation of mitotic sister chromatid separation (GO:2000816)2.50011811
200negative regulation of sister chromatid segregation (GO:0033046)2.50011811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse6.99206729
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.13694587
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.87812978
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.16337158
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.72310375
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.12863909
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.07037110
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.01565357
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67190476
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.06612783
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.90816809
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.88174875
13PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.29858904
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28962734
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13555232
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08945951
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.03673317
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0373592
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98569237
20E2F7_22180533_ChIP-Seq_HELA_Human1.96958135
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.87546021
22HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85407977
23TFEB_21752829_ChIP-Seq_HELA_Human1.83688869
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83511220
25PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80419985
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78368092
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73607204
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.67798347
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66928300
30ELK1_19687146_ChIP-ChIP_HELA_Human1.65961616
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65039348
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58800329
33AR_21909140_ChIP-Seq_LNCAP_Human1.58637113
34CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.54758305
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49871752
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49172880
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46951230
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.46915809
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.45202742
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44353710
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39353138
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.39297114
43CLOCK_20551151_ChIP-Seq_293T_Human1.39025936
44GATA1_19941826_ChIP-Seq_K562_Human1.36077226
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34807399
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33649798
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24779888
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.23193748
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.22565897
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22181549
51KAP1_22055183_ChIP-Seq_ESCs_Mouse1.21845713
52HNF4A_19822575_ChIP-Seq_HepG2_Human1.19259450
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18079062
54CIITA_25753668_ChIP-Seq_RAJI_Human1.16410098
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14730047
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14617442
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.13713487
58CHD1_26751641_Chip-Seq_LNCaP_Human1.11923851
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11762791
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09183508
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08446285
62GATA2_19941826_ChIP-Seq_K562_Human1.07734863
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07143855
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05939980
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05867834
66TTF2_22483619_ChIP-Seq_HELA_Human1.05459247
67HTT_18923047_ChIP-ChIP_STHdh_Human1.05133763
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04952067
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04002924
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02602726
71NCOR1_26117541_ChIP-Seq_K562_Human1.01207318
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01071227
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00672994
74EST1_17652178_ChIP-ChIP_JURKAT_Human0.99951529
75MYB_26560356_Chip-Seq_TH2_Human0.96762089
76FOXO3_23340844_ChIP-Seq_DLD1_Human0.96296344
77SMAD_19615063_ChIP-ChIP_OVARY_Human0.96233464
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96224682
79DCP1A_22483619_ChIP-Seq_HELA_Human0.95365322
80SOX17_20123909_ChIP-Seq_XEN_Mouse0.94366784
81* MYB_26560356_Chip-Seq_TH1_Human0.93571133
82FOXA2_19822575_ChIP-Seq_HepG2_Human0.93264963
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92614892
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92246616
85IRF8_22096565_ChIP-ChIP_GC-B_Human0.91413067
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91389470
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91388901
88GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91234153
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90028569
90GABP_19822575_ChIP-Seq_HepG2_Human0.89088841
91EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88904825
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88727410
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87545171
94SRF_21415370_ChIP-Seq_HL-1_Mouse0.87517220
95NELFA_20434984_ChIP-Seq_ESCs_Mouse0.85961418
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85659335
97SCL_19346495_ChIP-Seq_HPC-7_Human0.85254597
98MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85175584
99THAP11_20581084_ChIP-Seq_MESCs_Mouse0.85038713
100GATA4_25053715_ChIP-Seq_YYC3_Human0.84553315
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84461935
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84092016
103GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.84041287
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82809874
105RARA_24833708_ChIP-Seq_LIVER_Mouse0.80710268
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80550515
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80384892
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80384892
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80384892
110POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79762139
111KDM5A_27292631_Chip-Seq_BREAST_Human0.79325307
112ZNF263_19887448_ChIP-Seq_K562_Human0.79305762
113PKCTHETA_26484144_Chip-Seq_BREAST_Human0.78692672
114MYC_19079543_ChIP-ChIP_MESCs_Mouse0.78279576
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.78226884
116ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78182137
117SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77110354
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76850934
119SALL4_22934838_ChIP-ChIP_CD34+_Human0.76378855
120MYC_22102868_ChIP-Seq_BL_Human0.75714694
121NANOG_18555785_ChIP-Seq_MESCs_Mouse0.74845608
122SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74467418
123NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.74251266
124GATA1_22025678_ChIP-Seq_K562_Human0.74177081
125FOXP3_21729870_ChIP-Seq_TREG_Human0.73299760
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73153456
127* CEBPB_22108803_ChIP-Seq_LS180_Human0.69755809
128* RARB_24833708_ChIP-Seq_LIVER_Mouse0.69432372
129ZFX_18555785_ChIP-Seq_MESCs_Mouse0.67987985
130KLF4_18555785_ChIP-Seq_MESCs_Mouse0.67943411
131IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.66961725
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.66124716
133IRF1_19129219_ChIP-ChIP_H3396_Human0.65354609
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.64297115
135VDR_23849224_ChIP-Seq_CD4+_Human0.63995552
136TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.61538066
137THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.61398599
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61338373
139FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.60599540
140OCT4_18692474_ChIP-Seq_MEFs_Mouse0.60458164
141XRN2_22483619_ChIP-Seq_HELA_Human0.60327991
142CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.59832615
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.59744637
144ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.59566727
145MYC_18940864_ChIP-ChIP_HL60_Human0.59365578
146NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.59243392
147BRD4_27068464_Chip-Seq_AML-cells_Mouse0.59043059
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.59037527
149ATF3_27146783_Chip-Seq_COLON_Human0.57768346
150SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.57742021
151IRF8_21731497_ChIP-ChIP_J774_Mouse0.57686133
152ESR1_15608294_ChIP-ChIP_MCF-7_Human0.56412015
153CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.56395316
154SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.55875673
155P300_27268052_Chip-Seq_Bcells_Human0.55013489
156CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.54161740
157PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53695754
158SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.52495789
159PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.52056138
160* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.51945482
161FOXM1_23109430_ChIP-Seq_U2OS_Human0.51873193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.47772502
2MP0005360_urolithiasis7.13548741
3MP0005085_abnormal_gallbladder_physiolo5.83124000
4MP0005365_abnormal_bile_salt5.54635492
5MP0003806_abnormal_nucleotide_metabolis4.62544400
6MP0008875_abnormal_xenobiotic_pharmacok4.58675329
7MP0009840_abnormal_foam_cell3.98687727
8MP0003252_abnormal_bile_duct3.38378352
9MP0010329_abnormal_lipoprotein_level3.26964645
10MP0004147_increased_porphyrin_level2.81916448
11MP0003195_calcinosis2.63821424
12MP0005332_abnormal_amino_acid2.61534154
13MP0005083_abnormal_biliary_tract2.60703343
14MP0003191_abnormal_cellular_cholesterol2.41243160
15MP0010307_abnormal_tumor_latency2.25800707
16MP0000609_abnormal_liver_physiology2.19409299
17MP0003890_abnormal_embryonic-extraembry2.19105004
18* MP0001666_abnormal_nutrient_absorption2.15009956
19MP0008007_abnormal_cellular_replicative2.02215243
20MP0004019_abnormal_vitamin_homeostasis1.95884540
21MP0009697_abnormal_copulation1.90147021
22MP0005076_abnormal_cell_differentiation1.89176636
23* MP0002118_abnormal_lipid_homeostasis1.85259044
24MP0005319_abnormal_enzyme/_coenzyme1.83558543
25MP0003984_embryonic_growth_retardation1.81552780
26MP0001672_abnormal_embryogenesis/_devel1.81218160
27MP0005380_embryogenesis_phenotype1.81218160
28MP0008932_abnormal_embryonic_tissue1.81099215
29MP0002088_abnormal_embryonic_growth/wei1.76230425
30MP0003718_maternal_effect1.75488683
31MP0001697_abnormal_embryo_size1.74916723
32* MP0005451_abnormal_body_composition1.74374418
33MP0000350_abnormal_cell_proliferation1.72652735
34MP0003705_abnormal_hypodermis_morpholog1.72595854
35MP0001764_abnormal_homeostasis1.67826223
36MP0002138_abnormal_hepatobiliary_system1.67630759
37MP0001873_stomach_inflammation1.66473707
38MP0002009_preneoplasia1.65482180
39MP0003186_abnormal_redox_activity1.62148327
40MP0002086_abnormal_extraembryonic_tissu1.61067299
41MP0004233_abnormal_muscle_weight1.53724903
42MP0001545_abnormal_hematopoietic_system1.44916184
43MP0005397_hematopoietic_system_phenotyp1.44916184
44MP0003221_abnormal_cardiomyocyte_apopto1.43876075
45MP0003868_abnormal_feces_composition1.42176287
46MP0008877_abnormal_DNA_methylation1.41315828
47MP0002080_prenatal_lethality1.40773154
48MP0003941_abnormal_skin_development1.39764626
49MP0005584_abnormal_enzyme/coenzyme_acti1.36409081
50MP0003011_delayed_dark_adaptation1.35260402
51MP0003656_abnormal_erythrocyte_physiolo1.34774280
52MP0002877_abnormal_melanocyte_morpholog1.33501440
53MP0000598_abnormal_liver_morphology1.29976974
54MP0002396_abnormal_hematopoietic_system1.27718707
55MP0002084_abnormal_developmental_patter1.26561990
56MP0005670_abnormal_white_adipose1.25827930
57MP0000383_abnormal_hair_follicle1.25452351
58MP0003943_abnormal_hepatobiliary_system1.21946255
59MP0001929_abnormal_gametogenesis1.21612577
60MP0000313_abnormal_cell_death1.21420772
61MP0002166_altered_tumor_susceptibility1.21178220
62MP0010678_abnormal_skin_adnexa1.19699418
63MP0004808_abnormal_hematopoietic_stem1.15044895
64MP0003786_premature_aging1.14322467
65MP0002006_tumorigenesis1.13516300
66MP0010368_abnormal_lymphatic_system1.13254295
67MP0009643_abnormal_urine_homeostasis1.12997765
68MP0009763_increased_sensitivity_to1.10873046
69MP0005647_abnormal_sex_gland1.09417522
70MP0005621_abnormal_cell_physiology1.06434927
71MP0010234_abnormal_vibrissa_follicle1.05164324
72MP0003763_abnormal_thymus_physiology1.04404590
73MP0004185_abnormal_adipocyte_glucose1.03970736
74MP0002210_abnormal_sex_determination1.03942268
75MP0009764_decreased_sensitivity_to1.03005190
76MP0005395_other_phenotype1.02088090
77* MP0009115_abnormal_fat_cell1.01324748
78MP0008469_abnormal_protein_level0.99913955
79MP0005408_hypopigmentation0.99898040
80MP0002254_reproductive_system_inflammat0.99715696
81MP0004197_abnormal_fetal_growth/weight/0.96867668
82MP0002085_abnormal_embryonic_tissue0.95488639
83MP0003693_abnormal_embryo_hatching0.94040573
84MP0003566_abnormal_cell_adhesion0.91946876
85MP0000604_amyloidosis0.91436094
86MP0006036_abnormal_mitochondrial_physio0.90765518
87MP0002398_abnormal_bone_marrow0.88590626
88MP0005384_cellular_phenotype0.85243449
89MP0008995_early_reproductive_senescence0.84660438
90MP0009765_abnormal_xenobiotic_induced0.84628616
91MP0000703_abnormal_thymus_morphology0.83559132
92MP0005266_abnormal_metabolism0.81909881
93MP0002722_abnormal_immune_system0.80565798
94MP0005376_homeostasis/metabolism_phenot0.79693762
95MP0001853_heart_inflammation0.79477899
96MP0001145_abnormal_male_reproductive0.78867505
97MP0000689_abnormal_spleen_morphology0.77948959
98MP0004264_abnormal_extraembryonic_tissu0.77759679
99MP0005501_abnormal_skin_physiology0.77130172
100MP0005636_abnormal_mineral_homeostasis0.77120610
101* MP0009642_abnormal_blood_homeostasis0.76586411
102MP0000653_abnormal_sex_gland0.76131929
103MP0003436_decreased_susceptibility_to0.75713084
104MP0002132_abnormal_respiratory_system0.74859678
105MP0006082_CNS_inflammation0.73752703
106MP0008004_abnormal_stomach_pH0.73399021
107MP0004036_abnormal_muscle_relaxation0.72580679
108MP0001216_abnormal_epidermal_layer0.71218299
109MP0004084_abnormal_cardiac_muscle0.70772142
110MP0000358_abnormal_cell_content/0.69690146
111MP0008961_abnormal_basal_metabolism0.68511355
112MP0000627_abnormal_mammary_gland0.67939712
113MP0008260_abnormal_autophagy0.67366771
114MP0005310_abnormal_salivary_gland0.67162745
115MP0004134_abnormal_chest_morphology0.67122953
116MP0004947_skin_inflammation0.66228957
117MP0001191_abnormal_skin_condition0.64184021
118MP0002970_abnormal_white_adipose0.63915932
119MP0003698_abnormal_male_reproductive0.63892162
120MP0005334_abnormal_fat_pad0.62473058
121MP0001661_extended_life_span0.62257172
122MP0005464_abnormal_platelet_physiology0.61071424
123MP0006035_abnormal_mitochondrial_morpho0.60368619
124MP0002876_abnormal_thyroid_physiology0.58657310
125MP0009672_abnormal_birth_weight0.58076901
126MP0009053_abnormal_anal_canal0.55697385
127MP0008873_increased_physiological_sensi0.55095105
128MP0003111_abnormal_nucleus_morphology0.54549867
129MP0001756_abnormal_urination0.53811641
130MP0002971_abnormal_brown_adipose0.53080503
131MP0004957_abnormal_blastocyst_morpholog0.52820295
132MP0003699_abnormal_female_reproductive0.51872215
133MP0001915_intracranial_hemorrhage0.50981752
134MP0004782_abnormal_surfactant_physiolog0.48765413
135MP0010094_abnormal_chromosome_stability0.47861462
136MP0002078_abnormal_glucose_homeostasis0.47524156
137MP0000639_abnormal_adrenal_gland0.47491611
138MP0005220_abnormal_exocrine_pancreas0.47133301
139MP0002136_abnormal_kidney_physiology0.46243318
140MP0001845_abnormal_inflammatory_respons0.45007401
141MP0009785_altered_susceptibility_to0.44801755
142MP0001119_abnormal_female_reproductive0.44432453
143MP0001730_embryonic_growth_arrest0.43326865
144MP0010352_gastrointestinal_tract_polyps0.42734052
145MP0003453_abnormal_keratinocyte_physiol0.42166153
146MP0005023_abnormal_wound_healing0.41894855
147MP0008058_abnormal_DNA_repair0.41769557
148MP0005166_decreased_susceptibility_to0.40880174
149MP0003950_abnormal_plasma_membrane0.40625785
150MP0002796_impaired_skin_barrier0.39310595
151MP0001881_abnormal_mammary_gland0.38638749
152MP0008057_abnormal_DNA_replication0.38480180
153MP0005666_abnormal_adipose_tissue0.36551305
154MP0003077_abnormal_cell_cycle0.35001521
155MP0002019_abnormal_tumor_incidence0.34112938
156MP0005084_abnormal_gallbladder_morpholo0.34081302
157MP0000427_abnormal_hair_cycle0.33633429
158MP0005535_abnormal_body_temperature0.33168663
159MP0001243_abnormal_dermal_layer0.32732084
160MP0003646_muscle_fatigue0.32497345
161MP0003724_increased_susceptibility_to0.32144989
162MP0003329_amyloid_beta_deposits0.31975422
163MP0004381_abnormal_hair_follicle0.31905664
164MP0000685_abnormal_immune_system0.31904631
165MP0009333_abnormal_splenocyte_physiolog0.31874094

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.26289919
2Intrahepatic cholestasis (HP:0001406)6.97070617
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.71140508
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.62185723
5Hypobetalipoproteinemia (HP:0003563)6.28448563
6Xanthomatosis (HP:0000991)5.92657926
7Prolonged partial thromboplastin time (HP:0003645)5.88605944
8Hyperlipoproteinemia (HP:0010980)5.65257031
9Papillary thyroid carcinoma (HP:0002895)5.19281944
10Complement deficiency (HP:0004431)4.84716416
11Hypolipoproteinemia (HP:0010981)4.66937524
12Hyperglycinemia (HP:0002154)4.62653583
13Chromosomal breakage induced by crosslinking agents (HP:0003221)4.51908883
14Chromsome breakage (HP:0040012)4.51561102
15Hyperammonemia (HP:0001987)4.49461845
16Abnormality of methionine metabolism (HP:0010901)4.36914456
17Abnormality of pyrimidine metabolism (HP:0004353)4.31601680
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.29261325
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.29001996
20Joint hemorrhage (HP:0005261)4.22664273
21Hyperglycinuria (HP:0003108)4.18271346
22Abnormality of the common coagulation pathway (HP:0010990)4.17840579
23Abnormality of glycine metabolism (HP:0010895)4.06047308
24Abnormality of serine family amino acid metabolism (HP:0010894)4.06047308
25Abnormality of aspartate family amino acid metabolism (HP:0010899)4.05978353
26Hypoalphalipoproteinemia (HP:0003233)4.02515991
27Fat malabsorption (HP:0002630)3.94077661
28Epidermoid cyst (HP:0200040)3.86610716
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.71596400
30Thyroid carcinoma (HP:0002890)3.69062774
31Ketosis (HP:0001946)3.63852158
32Abnormality of complement system (HP:0005339)3.60766891
33Nephroblastoma (Wilms tumor) (HP:0002667)3.59035284
34Conjugated hyperbilirubinemia (HP:0002908)3.55450722
35Acute myeloid leukemia (HP:0004808)3.54241343
36Abnormality of the intrinsic pathway (HP:0010989)3.49069873
37Abnormality of serum amino acid levels (HP:0003112)3.42757530
38Spontaneous abortion (HP:0005268)3.40930664
39Hypoglycemic coma (HP:0001325)3.39319275
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39033063
41Embryonal renal neoplasm (HP:0011794)3.38482319
42Myocardial infarction (HP:0001658)3.34315342
43Abnormality of fatty-acid metabolism (HP:0004359)3.32786519
44Hypercholesterolemia (HP:0003124)3.29429126
45Anal stenosis (HP:0002025)3.21933401
46Steatorrhea (HP:0002570)3.16880032
47Abnormality of nucleobase metabolism (HP:0010932)3.12646835
48Hyperbilirubinemia (HP:0002904)3.07744864
49Delayed CNS myelination (HP:0002188)2.86637371
50Abnormality of chromosome stability (HP:0003220)2.82766706
51Rhabdomyosarcoma (HP:0002859)2.77252041
52Prominent nose (HP:0000448)2.76872659
53Cutaneous melanoma (HP:0012056)2.76754633
54Spastic diplegia (HP:0001264)2.75278128
55Autoamputation (HP:0001218)2.69276770
56Hepatocellular carcinoma (HP:0001402)2.68466308
57Systemic lupus erythematosus (HP:0002725)2.68345760
58Lethargy (HP:0001254)2.67015123
59Dicarboxylic aciduria (HP:0003215)2.65922237
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.65922237
61Deep philtrum (HP:0002002)2.63613408
62Abnormality of the heme biosynthetic pathway (HP:0010472)2.63456952
63Recurrent gram-negative bacterial infections (HP:0005420)2.59637857
64Vascular calcification (HP:0004934)2.58354966
65Abnormality of the preputium (HP:0100587)2.57152021
66Hypochromic microcytic anemia (HP:0004840)2.55541277
67Malnutrition (HP:0004395)2.54014265
68Abnormality of purine metabolism (HP:0004352)2.53169412
69Metabolic acidosis (HP:0001942)2.51812960
70Abnormal auditory evoked potentials (HP:0006958)2.42935600
71Skin nodule (HP:0200036)2.41502423
72Curly hair (HP:0002212)2.40382723
73Cholecystitis (HP:0001082)2.38441617
74Abnormal gallbladder physiology (HP:0012438)2.38441617
75Myelodysplasia (HP:0002863)2.37778594
76Birth length less than 3rd percentile (HP:0003561)2.37118312
77Abnormal gallbladder morphology (HP:0012437)2.35824789
78Irritability (HP:0000737)2.34789997
79Heterotopia (HP:0002282)2.34703553
80Cholelithiasis (HP:0001081)2.32465648
81Gout (HP:0001997)2.31259840
82Autoimmune hemolytic anemia (HP:0001890)2.29027058
83Ketoacidosis (HP:0001993)2.28486120
84Insidious onset (HP:0003587)2.27863199
85Termporal pattern (HP:0011008)2.27863199
86Esophageal varix (HP:0002040)2.26561632
87Thrombophlebitis (HP:0004418)2.25825834
88Freckling (HP:0001480)2.25692312
89Premature ovarian failure (HP:0008209)2.22340891
90Embryonal neoplasm (HP:0002898)2.22299995
91Abnormal cartilage morphology (HP:0002763)2.19623767
92Cardiovascular calcification (HP:0011915)2.19063546
93Nausea (HP:0002018)2.17868421
94Cafe-au-lait spot (HP:0000957)2.15740085
95Brushfield spots (HP:0001088)2.14079606
96Abnormality of iron homeostasis (HP:0011031)2.13034868
97Gingival bleeding (HP:0000225)2.12168052
98Small intestinal stenosis (HP:0012848)2.11174190
99Duodenal stenosis (HP:0100867)2.11174190
100Abnormality of endocrine pancreas physiology (HP:0012093)2.10472150
101Abnormality of the pancreatic islet cells (HP:0006476)2.10472150
102Medulloblastoma (HP:0002885)2.09916442
103Homocystinuria (HP:0002156)2.09546532
104Abnormality of homocysteine metabolism (HP:0010919)2.09546532
105Cerebral edema (HP:0002181)2.08745077
106Amyloidosis (HP:0011034)2.05946370
107Septate vagina (HP:0001153)2.05540120
108Glomerulonephritis (HP:0000099)2.05335182
109Acanthocytosis (HP:0001927)2.04849042
110Abnormality of transition element cation homeostasis (HP:0011030)2.04541150
111Subaortic stenosis (HP:0001682)2.04278964
112Abnormality of the left ventricular outflow tract (HP:0011103)2.04278964
113Osteomalacia (HP:0002749)2.03014080
114Pancreatitis (HP:0001733)2.02595319
115Increased nuchal translucency (HP:0010880)2.01605036
116Increased mean platelet volume (HP:0011877)2.01280235
117Aplasia/Hypoplasia of the uvula (HP:0010293)2.00487025
118Ankyloglossia (HP:0010296)2.00119027
119Neonatal onset (HP:0003623)1.99566025
120Abnormality of the fingertips (HP:0001211)1.99098720
121Upper limb muscle weakness (HP:0003484)1.98020420
122Opisthotonus (HP:0002179)1.97710246
123Spastic paraparesis (HP:0002313)1.95804717
124Gonadotropin excess (HP:0000837)1.94118073
125Generalized aminoaciduria (HP:0002909)1.92231453
126Vomiting (HP:0002013)1.91554188
127Late onset (HP:0003584)1.90897407
128Progressive external ophthalmoplegia (HP:0000590)1.88486065
129Poikilocytosis (HP:0004447)1.87436455
130Menorrhagia (HP:0000132)1.87366488
131Abnormality of the ileum (HP:0001549)1.87105827
132Duplicated collecting system (HP:0000081)1.86411253
133Volvulus (HP:0002580)1.85857877
134Abnormality of the gallbladder (HP:0005264)1.84653664
135Meckel diverticulum (HP:0002245)1.84566755
136Abnormal protein glycosylation (HP:0012346)1.84207537
137Abnormal glycosylation (HP:0012345)1.84207537
138Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84207537
139Abnormal protein N-linked glycosylation (HP:0012347)1.84207537
140Pancreatic islet-cell hyperplasia (HP:0004510)1.83729432
141Polycythemia (HP:0001901)1.83724960
142Menstrual irregularities (HP:0000858)1.83452110
143Hyperglycemia (HP:0003074)1.83221072
144Ectropion (HP:0000656)1.83034251
145Abnormal enzyme/coenzyme activity (HP:0012379)1.82767159
146Leiomyosarcoma (HP:0100243)1.82561778
147Uterine leiomyosarcoma (HP:0002891)1.82561778
148Upper motor neuron abnormality (HP:0002127)1.82184069
149Megaloblastic anemia (HP:0001889)1.81787659
150Overlapping toe (HP:0001845)1.80966386
151Increased serum ferritin (HP:0003281)1.80921068
152Rickets (HP:0002748)1.79827031
153Hemorrhage of the eye (HP:0011885)1.79736169
154Mitral stenosis (HP:0001718)1.79022939
155Neoplasm of the thyroid gland (HP:0100031)1.78743373
156Anhidrosis (HP:0000970)1.78341314
157Microvesicular hepatic steatosis (HP:0001414)1.77729348
158Long eyelashes (HP:0000527)1.77290443
159Abnormal pancreas size (HP:0012094)1.76941910
160Entropion (HP:0000621)1.76600792
161Cortical dysplasia (HP:0002539)1.76432728
162Symptomatic seizures (HP:0011145)1.75949571
163Abnormality of the duodenum (HP:0002246)1.74366705
164Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73598279
165Gastrointestinal carcinoma (HP:0002672)1.73487641
166Malignant gastrointestinal tract tumors (HP:0006749)1.73487641
167Squamous cell carcinoma (HP:0002860)1.73236389
168Proximal tubulopathy (HP:0000114)1.72520338
169Abnormality of oral frenula (HP:0000190)1.72467158
170Abnormality of lateral ventricle (HP:0030047)1.72188952
171Hypergonadotropic hypogonadism (HP:0000815)1.71771781
172Elevated hepatic transaminases (HP:0002910)1.71413628
173Hypoglycemic seizures (HP:0002173)1.71130848
174Neoplasm of the adrenal cortex (HP:0100641)1.70763821
175Abnormal umbilical cord blood vessels (HP:0011403)1.70621768
176Single umbilical artery (HP:0001195)1.70621768
177Abnormality of the fetal cardiovascular system (HP:0010948)1.70621768
178Sensorimotor neuropathy (HP:0007141)1.70333676
179B lymphocytopenia (HP:0010976)1.68407709
180Reticulocytosis (HP:0001923)1.67773542
181Subcapsular cataract (HP:0000523)1.67713496
182Renal cortical cysts (HP:0000803)1.65678156
183Hypertriglyceridemia (HP:0002155)1.65332612
184Abnormal platelet volume (HP:0011876)1.64107684
185Gonadal dysgenesis (HP:0000133)1.63544532
186Neoplasm of striated muscle (HP:0009728)1.62550684
187Clubbing of toes (HP:0100760)1.62145704
188Abnormality of small intestinal villus morphology (HP:0011472)1.61243277
189Villous atrophy (HP:0011473)1.61243277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.36369394
2CDK123.88781182
3TAOK33.56341840
4ERN13.51561490
5FGFR43.38220412
6SCYL23.13542143
7CAMK1G2.61917146
8WEE12.52940825
9PNCK2.33161244
10BRD42.32975092
11MKNK22.21325124
12CAMK1D2.19946521
13TSSK62.08902507
14TRIM282.08892184
15MOS2.04233430
16LATS12.00971528
17PKN22.00009343
18TRIB31.94015056
19BMPR21.92363738
20SIK11.91661148
21ERBB41.90534713
22BUB11.89097142
23MAP2K31.88859556
24TYK21.77268164
25NME21.73609795
26MAP3K21.71158756
27CDK81.57951595
28AKT31.53768002
29ABL21.52635367
30EIF2AK11.51108252
31IRAK31.49242673
32CDK41.49156909
33MAP3K111.47613017
34MAP2K41.47062811
35STK38L1.44709597
36WNK11.42131336
37MAP3K31.40898723
38FLT31.37965056
39TEC1.37663549
40RAF11.35015483
41TTK1.34921592
42KDR1.34236832
43SRPK11.34071465
44MAPK111.33366749
45ACVR1B1.33247783
46PBK1.31459278
47PIM11.30555502
48MST41.30196033
49MKNK11.24834168
50NEK21.21633594
51NEK91.20874429
52NLK1.20189919
53PLK31.14203606
54PLK41.14126996
55CHEK11.12867241
56PIK3CG1.12521269
57PTK61.12340371
58STK41.11780595
59KSR21.11421302
60GRK61.10740541
61MAP3K11.09130225
62ATM1.08821524
63EPHA21.07969419
64CDC71.06682960
65TBK11.06059986
66TAOK21.05652528
67MAP4K11.05081213
68ATR1.03347923
69OBSCN1.02178133
70FGFR31.00414430
71YES10.99713450
72CDK60.98828041
73MST1R0.98359848
74STK160.97839109
75KSR10.95538843
76NEK10.95331989
77RIPK40.94142604
78LATS20.93811898
79JAK20.93728852
80PRPF4B0.93314166
81JAK30.92443513
82BLK0.91362937
83BRSK20.90651483
84MTOR0.90383771
85TRPM70.90003547
86CLK10.86680271
87SIK30.86042971
88MAP3K50.85905925
89PLK10.84014150
90CSNK1G10.83499482
91STK100.83462744
92MAP3K100.78812570
93MAP3K80.76076038
94BRAF0.75184051
95MAPKAPK30.75076132
96MAP3K90.73927164
97MAP3K140.72611838
98CCNB10.72374910
99BRSK10.72143705
100DYRK20.71255291
101MAP3K60.69578767
102EIF2AK30.69108872
103CSNK1G30.68733165
104MAPK40.68092145
105CHEK20.66485255
106BMX0.66102384
107MELK0.65596567
108CDK20.65352531
109PASK0.64884524
110RIPK10.64324479
111RPS6KB10.63799328
112RPS6KA40.63624145
113NEK60.63014531
114MAP2K60.62992826
115MAPK120.62686945
116TGFBR10.62203119
117STK30.61781793
118BMPR1B0.59867738
119TAOK10.59307076
120CDK10.59203619
121AURKA0.58987412
122INSRR0.58637958
123CDK70.58336609
124PDK20.54794726
125ZAP700.53491548
126CSF1R0.51381103
127CSNK1A1L0.49814471
128DYRK30.48262563
129AURKB0.48057361
130FGFR10.46338326
131PAK20.44936678
132MAP2K20.44119764
133EIF2AK20.43453189
134NUAK10.42860933
135EPHB10.41821650
136PRKAA20.41591812
137CSNK2A10.41586224
138MET0.41360432
139PDGFRB0.40176072
140TNIK0.39868641
141TIE10.39706050
142EEF2K0.37336487
143PRKAA10.37022063
144BTK0.37009129
145KIT0.36420271
146MAPK100.36064828
147CDK90.35618584
148JAK10.35219789
149CSNK1E0.34842530
150PINK10.34774186
151BCR0.34332142
152CSNK1G20.33497505
153RPS6KB20.33054324
154PRKCZ0.32428393
155MAP3K70.32226920
156MAPK140.32135604
157PAK40.31628448
158GSK3B0.31320619
159CSNK2A20.30831066
160MARK30.30779333
161MAP3K40.30609526
162PIM20.30151711
163TXK0.29683180

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.37364827
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.14874836
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10781020
4Arginine biosynthesis_Homo sapiens_hsa002202.93872699
5Nitrogen metabolism_Homo sapiens_hsa009102.91903453
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.82944455
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68889082
8Complement and coagulation cascades_Homo sapiens_hsa046102.63468543
9Tryptophan metabolism_Homo sapiens_hsa003802.48151369
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48113891
11Fatty acid degradation_Homo sapiens_hsa000712.24049391
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19229856
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18966580
14Homologous recombination_Homo sapiens_hsa034402.12561650
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.03476492
16Peroxisome_Homo sapiens_hsa041462.01325699
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97024655
18Basal transcription factors_Homo sapiens_hsa030221.91383486
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.87937199
20Histidine metabolism_Homo sapiens_hsa003401.84693395
21Butanoate metabolism_Homo sapiens_hsa006501.83981494
22Selenocompound metabolism_Homo sapiens_hsa004501.83470360
23Thyroid cancer_Homo sapiens_hsa052161.83329353
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82744436
25Chemical carcinogenesis_Homo sapiens_hsa052041.79000398
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.78504249
27Staphylococcus aureus infection_Homo sapiens_hsa051501.77488574
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.75043394
29Fanconi anemia pathway_Homo sapiens_hsa034601.72165285
30mRNA surveillance pathway_Homo sapiens_hsa030151.71728082
31Propanoate metabolism_Homo sapiens_hsa006401.69119821
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69049541
33Folate biosynthesis_Homo sapiens_hsa007901.68551349
34Retinol metabolism_Homo sapiens_hsa008301.67199732
35beta-Alanine metabolism_Homo sapiens_hsa004101.65243313
36PPAR signaling pathway_Homo sapiens_hsa033201.64941187
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.64367181
38Chronic myeloid leukemia_Homo sapiens_hsa052201.64136366
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62049731
40Caffeine metabolism_Homo sapiens_hsa002321.59674707
41Fatty acid metabolism_Homo sapiens_hsa012121.57308515
42Pancreatic cancer_Homo sapiens_hsa052121.55838699
43Vitamin B6 metabolism_Homo sapiens_hsa007501.54378281
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54066695
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.50425991
46Biosynthesis of amino acids_Homo sapiens_hsa012301.48985511
47One carbon pool by folate_Homo sapiens_hsa006701.47033457
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44942628
49Phenylalanine metabolism_Homo sapiens_hsa003601.42031360
50Prostate cancer_Homo sapiens_hsa052151.39435618
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37378609
52Oocyte meiosis_Homo sapiens_hsa041141.36579807
53RNA degradation_Homo sapiens_hsa030181.35284329
54Non-small cell lung cancer_Homo sapiens_hsa052231.32409217
55Tyrosine metabolism_Homo sapiens_hsa003501.30895453
56Acute myeloid leukemia_Homo sapiens_hsa052211.28971457
57TGF-beta signaling pathway_Homo sapiens_hsa043501.27940372
58Steroid biosynthesis_Homo sapiens_hsa001001.21564992
59Carbon metabolism_Homo sapiens_hsa012001.20890341
60MicroRNAs in cancer_Homo sapiens_hsa052061.19824779
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.18143322
62Bile secretion_Homo sapiens_hsa049761.18003843
63mTOR signaling pathway_Homo sapiens_hsa041501.15650929
64Pyruvate metabolism_Homo sapiens_hsa006201.15327939
65Sulfur relay system_Homo sapiens_hsa041221.14238826
66Fatty acid elongation_Homo sapiens_hsa000621.12999840
67Arginine and proline metabolism_Homo sapiens_hsa003301.12766924
68Starch and sucrose metabolism_Homo sapiens_hsa005001.11269891
69Fat digestion and absorption_Homo sapiens_hsa049751.09091496
70Viral carcinogenesis_Homo sapiens_hsa052031.08639164
71Renal cell carcinoma_Homo sapiens_hsa052111.08067399
72Adherens junction_Homo sapiens_hsa045201.07596556
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05188701
74Circadian rhythm_Homo sapiens_hsa047101.04672048
75Bladder cancer_Homo sapiens_hsa052191.02417817
76Spliceosome_Homo sapiens_hsa030401.01838809
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99403909
78Measles_Homo sapiens_hsa051620.99139775
79ABC transporters_Homo sapiens_hsa020100.97314700
80N-Glycan biosynthesis_Homo sapiens_hsa005100.96332971
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95223107
82Hepatitis B_Homo sapiens_hsa051610.94888631
83Vitamin digestion and absorption_Homo sapiens_hsa049770.94821015
84Pentose phosphate pathway_Homo sapiens_hsa000300.91132853
85Sphingolipid metabolism_Homo sapiens_hsa006000.90118329
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.89917909
87Endometrial cancer_Homo sapiens_hsa052130.88977952
88Colorectal cancer_Homo sapiens_hsa052100.88969024
89Small cell lung cancer_Homo sapiens_hsa052220.87755324
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86963040
91Sulfur metabolism_Homo sapiens_hsa009200.86406213
92Glutathione metabolism_Homo sapiens_hsa004800.85414421
93Glioma_Homo sapiens_hsa052140.77892100
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.75252782
95Dorso-ventral axis formation_Homo sapiens_hsa043200.74027392
96Epstein-Barr virus infection_Homo sapiens_hsa051690.73923361
97ErbB signaling pathway_Homo sapiens_hsa040120.73314172
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72907513
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72158670
100FoxO signaling pathway_Homo sapiens_hsa040680.71972349
101Lysine degradation_Homo sapiens_hsa003100.69792341
102Insulin signaling pathway_Homo sapiens_hsa049100.68434302
103Herpes simplex infection_Homo sapiens_hsa051680.64311766
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.63857065
105Influenza A_Homo sapiens_hsa051640.62459023
106HTLV-I infection_Homo sapiens_hsa051660.61966309
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58025349
108T cell receptor signaling pathway_Homo sapiens_hsa046600.57500976
109Glycerolipid metabolism_Homo sapiens_hsa005610.56936887
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56403800
111Metabolic pathways_Homo sapiens_hsa011000.54185130
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53835727
113Proteasome_Homo sapiens_hsa030500.53308046
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52498290
115Inositol phosphate metabolism_Homo sapiens_hsa005620.51764487
116Prolactin signaling pathway_Homo sapiens_hsa049170.48716998
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48426426
118Platelet activation_Homo sapiens_hsa046110.47441474
119Linoleic acid metabolism_Homo sapiens_hsa005910.46658135
120Pyrimidine metabolism_Homo sapiens_hsa002400.46606144
121Proteoglycans in cancer_Homo sapiens_hsa052050.45991548
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.45588347
123Fructose and mannose metabolism_Homo sapiens_hsa000510.44968698
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44162757
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43682113
126Regulation of autophagy_Homo sapiens_hsa041400.42795399
127HIF-1 signaling pathway_Homo sapiens_hsa040660.42492830
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42301690
129Protein export_Homo sapiens_hsa030600.41797299
130Hepatitis C_Homo sapiens_hsa051600.41561951
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.38992981
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38523754
133Type II diabetes mellitus_Homo sapiens_hsa049300.38242535
134Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38177226
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36967686
136Apoptosis_Homo sapiens_hsa042100.36886929
137Melanoma_Homo sapiens_hsa052180.35862726
138Shigellosis_Homo sapiens_hsa051310.35673613
139Galactose metabolism_Homo sapiens_hsa000520.33008131
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29781078
141Prion diseases_Homo sapiens_hsa050200.28226882
142Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26849620
143DNA replication_Homo sapiens_hsa030300.22306893
144RNA polymerase_Homo sapiens_hsa030200.20542967
145Fatty acid biosynthesis_Homo sapiens_hsa000610.20378764
146RNA transport_Homo sapiens_hsa030130.17202402
147Insulin resistance_Homo sapiens_hsa049310.14603841
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.12172718
149Ovarian steroidogenesis_Homo sapiens_hsa049130.09486847
150Base excision repair_Homo sapiens_hsa034100.05094331
151Arachidonic acid metabolism_Homo sapiens_hsa005900.04977376
152Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.00411456
153Glucagon signaling pathway_Homo sapiens_hsa04922-0.0936243
154Cell cycle_Homo sapiens_hsa04110-0.0829052
155RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0812627
156AMPK signaling pathway_Homo sapiens_hsa04152-0.0776091
157p53 signaling pathway_Homo sapiens_hsa04115-0.0729222
158Nucleotide excision repair_Homo sapiens_hsa03420-0.0655897
159Mismatch repair_Homo sapiens_hsa03430-0.0509508
160Legionellosis_Homo sapiens_hsa05134-0.0286554
161Non-homologous end-joining_Homo sapiens_hsa03450-0.0145837
162Purine metabolism_Homo sapiens_hsa00230-0.0100339

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