RSAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.48270955
2central nervous system myelination (GO:0022010)6.48270955
3NADH metabolic process (GO:0006734)4.83355283
4presynaptic membrane organization (GO:0097090)4.78215952
5proline biosynthetic process (GO:0006561)4.55027431
6negative regulation of cell size (GO:0045792)4.26038395
7long-chain fatty acid biosynthetic process (GO:0042759)4.24314589
8presynaptic membrane assembly (GO:0097105)4.13545079
9cellular hyperosmotic response (GO:0071474)4.03714109
10Golgi transport vesicle coating (GO:0048200)4.02768414
11COPI coating of Golgi vesicle (GO:0048205)4.02768414
12negative regulation of necrotic cell death (GO:0060547)3.92859200
13tricarboxylic acid metabolic process (GO:0072350)3.92384842
14neutrophil activation involved in immune response (GO:0002283)3.90117721
15proline metabolic process (GO:0006560)3.84792924
16negative regulation of necroptotic process (GO:0060546)3.66301362
17mannose metabolic process (GO:0006013)3.49879698
18valine metabolic process (GO:0006573)3.48887694
19retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.43850824
203-UTR-mediated mRNA stabilization (GO:0070935)3.43165664
21photoreceptor cell differentiation (GO:0046530)3.39763443
22eye photoreceptor cell differentiation (GO:0001754)3.39763443
23neuronal action potential propagation (GO:0019227)3.38886445
24protein retention in ER lumen (GO:0006621)3.37644982
25poly(A)+ mRNA export from nucleus (GO:0016973)3.36732986
26fatty acid elongation (GO:0030497)3.32158970
27regulation of necrotic cell death (GO:0010939)3.30469030
282-oxoglutarate metabolic process (GO:0006103)3.30094079
29response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.27329724
30peptidyl-arginine omega-N-methylation (GO:0035247)3.25955334
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25382256
32neuron cell-cell adhesion (GO:0007158)3.18410913
33mucosal-associated lymphoid tissue development (GO:0048537)3.17868727
34Peyers patch development (GO:0048541)3.17868727
35oxaloacetate metabolic process (GO:0006107)3.15308252
36peptidyl-arginine N-methylation (GO:0035246)3.11935548
37peptidyl-arginine methylation (GO:0018216)3.11935548
38postsynaptic membrane organization (GO:0001941)3.10569749
39L-phenylalanine metabolic process (GO:0006558)3.04359524
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.04359524
41negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.03324830
42GDP-mannose metabolic process (GO:0019673)3.02336469
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99180020
44creatine metabolic process (GO:0006600)2.98232282
45behavioral response to nicotine (GO:0035095)2.95074316
46spliceosomal tri-snRNP complex assembly (GO:0000244)2.95036778
47regulation of relaxation of muscle (GO:1901077)2.94658483
48carnitine shuttle (GO:0006853)2.94465918
49formation of translation preinitiation complex (GO:0001731)2.92712365
50regulation of translational fidelity (GO:0006450)2.92177814
51negative regulation of protein localization to cell surface (GO:2000009)2.91234835
52histone H4 deacetylation (GO:0070933)2.89935700
53pinocytosis (GO:0006907)2.89072813
54regulation of mammary gland epithelial cell proliferation (GO:0033599)2.88401612
55retrograde transport, endosome to Golgi (GO:0042147)2.87461723
56pentose-phosphate shunt (GO:0006098)2.85531593
57cellular response to epinephrine stimulus (GO:0071872)2.84999271
58neutrophil activation (GO:0042119)2.84112372
59regulation of activation of Janus kinase activity (GO:0010533)2.80580885
60purine nucleotide transport (GO:0015865)2.77051077
61G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.76307417
62regulation of necroptotic process (GO:0060544)2.75780476
63UV protection (GO:0009650)2.74819689
64negative regulation of neurotransmitter transport (GO:0051589)2.74447562
65ribosomal small subunit assembly (GO:0000028)2.72993962
66adenine nucleotide transport (GO:0051503)2.72916748
67regulation of cell communication by electrical coupling (GO:0010649)2.70195110
68response to epinephrine (GO:0071871)2.69016421
69cerebral cortex radially oriented cell migration (GO:0021799)2.68602999
70regulation of ARF GTPase activity (GO:0032312)2.67488893
71snRNA metabolic process (GO:0016073)2.67176339
72regulation of cholesterol metabolic process (GO:0090181)2.66955979
73nucleotide transmembrane transport (GO:1901679)2.66169376
74regulation of fatty acid biosynthetic process (GO:0042304)2.66138204
75regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.66126872
76gluconeogenesis (GO:0006094)2.65559856
77startle response (GO:0001964)2.65264690
78nucleoside diphosphate catabolic process (GO:0009134)2.63970728
79monosaccharide biosynthetic process (GO:0046364)2.63969766
80nucleoside diphosphate biosynthetic process (GO:0009133)2.63637051
81negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.63542690
82mitochondrion transport along microtubule (GO:0047497)2.63362893
83establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.63362893
84vocalization behavior (GO:0071625)2.62953892
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61423209
86L-amino acid import (GO:0043092)2.61267294
87negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.61100585
88neurotransmitter uptake (GO:0001504)2.59740634
89iron-sulfur cluster assembly (GO:0016226)2.59733502
90metallo-sulfur cluster assembly (GO:0031163)2.59733502
91histone H3 deacetylation (GO:0070932)2.58883196
92glycogen catabolic process (GO:0005980)2.58752394
93positive thymic T cell selection (GO:0045059)2.58310690
94positive regulation of action potential (GO:0045760)2.58022343
95intracellular estrogen receptor signaling pathway (GO:0030520)2.56998485
96ionotropic glutamate receptor signaling pathway (GO:0035235)2.55847433
97positive regulation of gamma-delta T cell activation (GO:0046645)2.55618686
98cell volume homeostasis (GO:0006884)2.53911782
99thymic T cell selection (GO:0045061)2.53762075
100skeletal muscle contraction (GO:0003009)2.53324857
101apoptotic process involved in morphogenesis (GO:0060561)2.52308166
102purine ribonucleotide transport (GO:0015868)2.51262774
103L-phenylalanine catabolic process (GO:0006559)2.51052511
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.51052511
105mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.50524476
106establishment of mitochondrion localization (GO:0051654)2.50312226
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.49451561
108mitochondrial fusion (GO:0008053)2.48688313
109granulocyte activation (GO:0036230)2.48286774
110carnitine transmembrane transport (GO:1902603)2.48281520
111neurotransmitter-gated ion channel clustering (GO:0072578)2.48191973
112hexose biosynthetic process (GO:0019319)2.47132214
113adult walking behavior (GO:0007628)2.46387841
114mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.46056514
115histone H3-K9 demethylation (GO:0033169)2.45887597
116regulation of ARF protein signal transduction (GO:0032012)2.45800958
117positive regulation of lipoprotein lipase activity (GO:0051006)2.45273078
118positive regulation of triglyceride lipase activity (GO:0061365)2.45273078
119neuronal ion channel clustering (GO:0045161)2.45180190
120snRNA processing (GO:0016180)2.44400219
121positive regulation of fatty acid biosynthetic process (GO:0045723)2.42209723
122glucose catabolic process (GO:0006007)2.40786081
123tricarboxylic acid cycle (GO:0006099)2.40563347
124dosage compensation (GO:0007549)2.39538199
125negative regulation of skeletal muscle tissue development (GO:0048642)2.39508861
126phosphate ion transmembrane transport (GO:0035435)2.39138727
127regulation of cholesterol homeostasis (GO:2000188)2.38733479
128glutamine family amino acid biosynthetic process (GO:0009084)2.38683019
129gamma-aminobutyric acid transport (GO:0015812)2.38571868
130protein complex biogenesis (GO:0070271)2.38224764
131glucan catabolic process (GO:0009251)2.37458506
132purinergic nucleotide receptor signaling pathway (GO:0035590)2.35665468
133cellular polysaccharide catabolic process (GO:0044247)2.35212707
134gamma-aminobutyric acid signaling pathway (GO:0007214)2.34287761
135substrate-independent telencephalic tangential migration (GO:0021826)2.33954295
136substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.33954295
137negative regulation of chemokine production (GO:0032682)2.33932449
138histone H4-K5 acetylation (GO:0043981)2.33165843
139histone H4-K8 acetylation (GO:0043982)2.33165843
140nonmotile primary cilium assembly (GO:0035058)2.32603826
141negative regulation of granulocyte differentiation (GO:0030853)2.31935161
142positive regulation of T cell mediated cytotoxicity (GO:0001916)2.31900912
143succinate metabolic process (GO:0006105)2.31718347
144GPI anchor biosynthetic process (GO:0006506)2.31576724
145histone arginine methylation (GO:0034969)2.31369712
146leukocyte degranulation (GO:0043299)2.30650764
147glycolytic process (GO:0006096)2.30593664
148deoxyribose phosphate biosynthetic process (GO:0046385)2.30335939
1492-deoxyribonucleotide biosynthetic process (GO:0009265)2.30335939
150positive regulation of protein dephosphorylation (GO:0035307)2.28522248
151protein kinase C signaling (GO:0070528)2.27785270
152neuron remodeling (GO:0016322)2.27514150
153GPI anchor metabolic process (GO:0006505)2.27212245
154cyclic nucleotide catabolic process (GO:0009214)2.27088307
155synaptic transmission, glutamatergic (GO:0035249)2.25915524
156amyloid precursor protein catabolic process (GO:0042987)2.25793953
157positive regulation of synapse maturation (GO:0090129)2.24624948
158regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.24342470
159superoxide anion generation (GO:0042554)2.24137339
160myelination (GO:0042552)2.23887165
161positive regulation of natural killer cell differentiation (GO:0032825)2.23056096
162glycine transport (GO:0015816)2.22142860
163neuromuscular process controlling posture (GO:0050884)2.21858299
164regulation of cardiac muscle cell contraction (GO:0086004)2.21856590
165response to redox state (GO:0051775)2.20704246
166cerebellar granule cell differentiation (GO:0021707)2.20594802
167regulation of collateral sprouting (GO:0048670)2.20529854
168regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.20503225
169regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.20328995
170detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.20328716
171regulation of actin filament-based movement (GO:1903115)2.19814346
172axon ensheathment (GO:0008366)2.18706916
173ensheathment of neurons (GO:0007272)2.18706916
174membrane assembly (GO:0071709)2.17634560
175extracellular regulation of signal transduction (GO:1900115)2.17321014
176extracellular negative regulation of signal transduction (GO:1900116)2.17321014
177positive regulation of synapse assembly (GO:0051965)2.17141787
178peptidyl-tyrosine autophosphorylation (GO:0038083)2.15760949
179cAMP catabolic process (GO:0006198)2.15486295
180positive regulation of cellular amine metabolic process (GO:0033240)2.14707942
181regulation of memory T cell differentiation (GO:0043380)2.12123474
182glutamate receptor signaling pathway (GO:0007215)2.11464710
183preassembly of GPI anchor in ER membrane (GO:0016254)2.10259027
184negative regulation of neurotransmitter secretion (GO:0046929)2.10253850
185amyloid precursor protein metabolic process (GO:0042982)2.10175498
186negative regulation of erythrocyte differentiation (GO:0045647)2.09808971
187cell differentiation involved in metanephros development (GO:0072202)2.08594624
188neuron-neuron synaptic transmission (GO:0007270)2.08495155
189regulation of T cell mediated cytotoxicity (GO:0001914)2.08173630
190lymph node development (GO:0048535)2.08037680
191adenosine metabolic process (GO:0046085)2.06874914
192righting reflex (GO:0060013)2.06815375
193import into cell (GO:0098657)2.06657350
194dopamine biosynthetic process (GO:0042416)2.05270303
195regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.04157898
196protein localization to synapse (GO:0035418)2.02350749
197striatum development (GO:0021756)2.02089298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.43321395
2GBX2_23144817_ChIP-Seq_PC3_Human4.42577547
3VDR_21846776_ChIP-Seq_THP-1_Human2.95005561
4MYC_22102868_ChIP-Seq_BL_Human2.84658007
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.54603303
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51902058
7TAF15_26573619_Chip-Seq_HEK293_Human2.50527585
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47378610
9LXR_22292898_ChIP-Seq_THP-1_Human2.46671008
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44695112
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.43140102
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42913821
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42637008
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30905613
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21271577
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20650217
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17972557
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.16600035
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14941740
20KDM2B_26808549_Chip-Seq_SUP-B15_Human2.12167589
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10672298
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09692675
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06690286
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.06659865
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.03823128
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.01626012
27DROSHA_22980978_ChIP-Seq_HELA_Human1.99116825
28KDM2B_26808549_Chip-Seq_DND41_Human1.96900776
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.94201862
30RACK7_27058665_Chip-Seq_MCF-7_Human1.92902959
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90491667
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90491667
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87302932
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87089419
35TCF7_22412390_ChIP-Seq_EML_Mouse1.84404487
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83974563
37P68_20966046_ChIP-Seq_HELA_Human1.83530811
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.83418908
39* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.79828633
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78960096
41P300_19829295_ChIP-Seq_ESCs_Human1.77096995
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76503115
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76449767
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75609916
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.75335301
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.75248203
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73907942
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72433940
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72241815
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71479965
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.69625616
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68896787
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68460878
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.67214496
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64302564
56MAF_26560356_Chip-Seq_TH1_Human1.63472731
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62136322
58CIITA_25753668_ChIP-Seq_RAJI_Human1.61897442
59* MAF_26560356_Chip-Seq_TH2_Human1.61007934
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60229504
61* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.60069867
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.57713523
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56292914
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55667067
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.54943314
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54832443
67GATA1_22025678_ChIP-Seq_K562_Human1.54657379
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.54138982
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53082471
70* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52947941
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52387025
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52293013
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51688444
74AR_21572438_ChIP-Seq_LNCaP_Human1.51552822
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51062664
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50457553
77MYC_18555785_ChIP-Seq_MESCs_Mouse1.50293075
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47091554
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46839892
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46551282
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45350177
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45257464
83SMC4_20622854_ChIP-Seq_HELA_Human1.44882925
84SCL_19346495_ChIP-Seq_HPC-7_Human1.44807502
85UTX_26944678_Chip-Seq_JUKART_Human1.43852762
86IGF1R_20145208_ChIP-Seq_DFB_Human1.43133790
87XRN2_22483619_ChIP-Seq_HELA_Human1.41310379
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.40731823
89ZNF263_19887448_ChIP-Seq_K562_Human1.40181638
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.39796916
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37612827
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.36335290
93P53_22387025_ChIP-Seq_ESCs_Mouse1.36114121
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36038932
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35730014
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.34999119
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34852193
98SMAD4_21799915_ChIP-Seq_A2780_Human1.34334291
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.34032190
100* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34000652
101SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33853127
102THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33827737
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.33621012
104VDR_24763502_ChIP-Seq_THP-1_Human1.33176389
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.32767977
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31787735
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.31586503
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.31537093
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30063810
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.30018898
111ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29663581
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.29489550
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29000509
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28871773
115P300_18555785_Chip-Seq_ESCs_Mouse1.28817812
116BCL6_27268052_Chip-Seq_Bcells_Human1.28812140
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28368994
118* CREB1_26743006_Chip-Seq_LNCaP_Human1.28263550
119REST_21632747_ChIP-Seq_MESCs_Mouse1.27963739
120PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27281671
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.27112675
122GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27090450
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.26931855
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26623808
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26321423
126* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26218631
127E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26213601
128JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26013609
129BCOR_27268052_Chip-Seq_Bcells_Human1.25469988
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25403519
131KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24614568
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24514927
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24371587
134KDM2B_26808549_Chip-Seq_K562_Human1.24319814
135RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24044189
136MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23982934
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23460875
138EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23178194
139KDM2B_26808549_Chip-Seq_JURKAT_Human1.22695643
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22305676
141ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22182011
142* NCOR1_26117541_ChIP-Seq_K562_Human1.20113264
143CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19956096
144UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18816866
145ETS1_21867929_ChIP-Seq_TH2_Mouse1.18561170
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17467694
147BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17303979
148TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17295261
149* RXR_22158963_ChIP-Seq_LIVER_Mouse1.17092097
150ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16297618
151NMYC_18555785_Chip-Seq_ESCs_Mouse1.15772987
152SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15098942
153SOX2_18555785_Chip-Seq_ESCs_Mouse1.14404865
154* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14170448
155* CTCF_26484167_Chip-Seq_Bcells_Mouse1.13275502
156OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12262049
157KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11414255
158* CTCF_21964334_Chip-Seq_Bcells_Human1.11377317
159TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11105933
160CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10899765
161TCF4_23295773_ChIP-Seq_U87_Human1.10267418
162EGR1_19374776_ChIP-ChIP_THP-1_Human1.10139439
163RARB_24833708_ChIP-Seq_LIVER_Mouse1.09866698
164* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09596440
165POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09247209
166GATA2_21666600_ChIP-Seq_HMVEC_Human1.08833200
167SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08450096
168IRF8_22096565_ChIP-ChIP_GC-B_Human1.08447346
169FOXP1_21924763_ChIP-Seq_HESCs_Human1.08190337
170MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08177357
171OCT4_18555785_Chip-Seq_ESCs_Mouse1.07692557
172FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07428027
173MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07275310
174KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07229841
175* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07117872
176ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07049834
177ZFX_18555785_Chip-Seq_ESCs_Mouse1.06948841
178MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06415449
179PU1_27457419_Chip-Seq_LIVER_Mouse1.06354054
180RUNX_20019798_ChIP-Seq_JUKART_Human1.05934233
181AHR_22903824_ChIP-Seq_MCF-7_Human1.04130681
182EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03375687
183IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02198256
184FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01740428
185RNF2_27304074_Chip-Seq_NSC_Mouse1.01438344
186ARNT_22903824_ChIP-Seq_MCF-7_Human1.00428874
187RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00019629
188POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98734614
189TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98734614
190CTCF_18555785_Chip-Seq_ESCs_Mouse0.98617157
191SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98211368
192TAL1_26923725_Chip-Seq_HPCs_Mouse0.98184408
193KLF4_18555785_Chip-Seq_ESCs_Mouse0.97809579
194ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96130738
195EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95988277
196STAT3_23295773_ChIP-Seq_U87_Human0.94859984
197ER_23166858_ChIP-Seq_MCF-7_Human0.94702792
198UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94569898
199TP53_18474530_ChIP-ChIP_U2OS_Human0.94494352
200KDM2B_26808549_Chip-Seq_REH_Human0.94320262

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.90338702
2MP0009278_abnormal_bone_marrow3.77744911
3MP0003880_abnormal_central_pattern3.33118671
4MP0008260_abnormal_autophagy3.13624731
5MP0001188_hyperpigmentation2.75076910
6MP0003172_abnormal_lysosome_physiology2.68697511
7MP0005409_darkened_coat_color2.68135660
8MP0003191_abnormal_cellular_cholesterol2.66975062
9MP0004233_abnormal_muscle_weight2.62259876
10MP0003300_gastrointestinal_ulcer2.61386769
11MP0001486_abnormal_startle_reflex2.55995939
12MP0004185_abnormal_adipocyte_glucose2.44154762
13MP0002272_abnormal_nervous_system2.43532598
14MP0009745_abnormal_behavioral_response2.42127738
15MP0000747_muscle_weakness2.37772420
16MP0009046_muscle_twitch2.34344689
17MP0003763_abnormal_thymus_physiology2.34000221
18MP0002064_seizures2.25309485
19MP0003329_amyloid_beta_deposits2.16905739
20MP0000566_synostosis2.09297672
21MP0000920_abnormal_myelination2.06793711
22MP0001501_abnormal_sleep_pattern2.04010245
23MP0003195_calcinosis2.02935359
24MP0002876_abnormal_thyroid_physiology1.97820696
25MP0005666_abnormal_adipose_tissue1.97321121
26MP0004142_abnormal_muscle_tone1.91309853
27MP0002396_abnormal_hematopoietic_system1.86642224
28MP0003436_decreased_susceptibility_to1.85180662
29MP0005330_cardiomyopathy1.83380916
30MP0004087_abnormal_muscle_fiber1.83066880
31MP0000003_abnormal_adipose_tissue1.80899824
32MP0000759_abnormal_skeletal_muscle1.80495820
33MP0006036_abnormal_mitochondrial_physio1.79897179
34MP0003635_abnormal_synaptic_transmissio1.79389889
35MP0002132_abnormal_respiratory_system1.73202617
36MP0005397_hematopoietic_system_phenotyp1.73168909
37MP0001545_abnormal_hematopoietic_system1.73168909
38MP0005670_abnormal_white_adipose1.72563941
39MP0005423_abnormal_somatic_nervous1.71802969
40MP0001984_abnormal_olfaction1.71277322
41MP0005375_adipose_tissue_phenotype1.70059335
42MP0001968_abnormal_touch/_nociception1.69578501
43MP0002269_muscular_atrophy1.66066710
44MP0004145_abnormal_muscle_electrophysio1.65347764
45MP0000678_abnormal_parathyroid_gland1.64036989
46MP0009840_abnormal_foam_cell1.62072457
47MP0004742_abnormal_vestibular_system1.58051911
48MP0005171_absent_coat_pigmentation1.56890107
49MP0001905_abnormal_dopamine_level1.56664158
50MP0002572_abnormal_emotion/affect_behav1.53983307
51MP0004510_myositis1.53829540
52MP0004859_abnormal_synaptic_plasticity1.52579778
53MP0002735_abnormal_chemical_nociception1.51773870
54MP0001348_abnormal_lacrimal_gland1.49218595
55MP0001529_abnormal_vocalization1.48021086
56MP0002067_abnormal_sensory_capabilities1.45923257
57MP0001661_extended_life_span1.45655428
58MP0001502_abnormal_circadian_rhythm1.44941812
59MP0005551_abnormal_eye_electrophysiolog1.42729458
60MP0002736_abnormal_nociception_after1.42200853
61MP0002638_abnormal_pupillary_reflex1.41961179
62MP0001970_abnormal_pain_threshold1.41478620
63MP0005646_abnormal_pituitary_gland1.40327679
64MP0000465_gastrointestinal_hemorrhage1.40090572
65MP0000013_abnormal_adipose_tissue1.39600118
66MP0010630_abnormal_cardiac_muscle1.39132535
67MP0002734_abnormal_mechanical_nocicepti1.38236603
68MP0010386_abnormal_urinary_bladder1.37151322
69MP0002106_abnormal_muscle_physiology1.36612307
70MP0008569_lethality_at_weaning1.35643490
71MP0002089_abnormal_postnatal_growth/wei1.35641296
72MP0005464_abnormal_platelet_physiology1.35503607
73MP0009333_abnormal_splenocyte_physiolog1.35125883
74MP0004808_abnormal_hematopoietic_stem1.34556518
75MP0005386_behavior/neurological_phenoty1.33525671
76MP0004924_abnormal_behavior1.33525671
77MP0004147_increased_porphyrin_level1.33510774
78MP0002009_preneoplasia1.33145563
79MP0003646_muscle_fatigue1.31768428
80MP0006276_abnormal_autonomic_nervous1.31332551
81MP0005671_abnormal_response_to1.31008855
82MP0004043_abnormal_pH_regulation1.30691128
83MP0003137_abnormal_impulse_conducting1.30441366
84MP0005645_abnormal_hypothalamus_physiol1.29402794
85MP0005365_abnormal_bile_salt1.28788015
86MP0002063_abnormal_learning/memory/cond1.28412990
87MP0001986_abnormal_taste_sensitivity1.26995285
88MP0002877_abnormal_melanocyte_morpholog1.25187409
89MP0000750_abnormal_muscle_regeneration1.23421961
90MP0006292_abnormal_olfactory_placode1.22734651
91MP0002971_abnormal_brown_adipose1.21287885
92MP0003950_abnormal_plasma_membrane1.21041945
93MP0005220_abnormal_exocrine_pancreas1.20652581
94MP0002822_catalepsy1.20165155
95MP0002733_abnormal_thermal_nociception1.19429714
96MP0003806_abnormal_nucleotide_metabolis1.19205283
97MP0008874_decreased_physiological_sensi1.18874502
98MP0001664_abnormal_digestion1.18568276
99MP0001835_abnormal_antigen_presentation1.18307307
100MP0000681_abnormal_thyroid_gland1.18033757
101MP0000703_abnormal_thymus_morphology1.17230970
102MP0000749_muscle_degeneration1.16873480
103MP0001485_abnormal_pinna_reflex1.16608792
104MP0003690_abnormal_glial_cell1.16603465
105MP0002557_abnormal_social/conspecific_i1.16505709
106MP0009785_altered_susceptibility_to1.16487224
107MP0001963_abnormal_hearing_physiology1.14275080
108MP0001849_ear_inflammation1.13086910
109MP0002139_abnormal_hepatobiliary_system1.12725004
110MP0005076_abnormal_cell_differentiation1.12493238
111MP0003705_abnormal_hypodermis_morpholog1.12298309
112MP0003787_abnormal_imprinting1.11979250
113MP0002837_dystrophic_cardiac_calcinosis1.11869749
114MP0009697_abnormal_copulation1.10798562
115MP0001440_abnormal_grooming_behavior1.10249250
116MP0004036_abnormal_muscle_relaxation1.09346678
117MP0004085_abnormal_heartbeat1.09294304
118MP0002138_abnormal_hepatobiliary_system1.08666838
119MP0002184_abnormal_innervation1.07459953
120MP0005369_muscle_phenotype1.07253973
121MP0002229_neurodegeneration1.06400481
122MP0004381_abnormal_hair_follicle1.05479473
123MP0005387_immune_system_phenotype1.05036095
124MP0001790_abnormal_immune_system1.05036095
125MP0005379_endocrine/exocrine_gland_phen1.04871903
126MP0002148_abnormal_hypersensitivity_rea1.04269274
127MP0002254_reproductive_system_inflammat1.02711269
128MP0000604_amyloidosis1.02605268
129MP0001270_distended_abdomen1.02302725
130MP0002398_abnormal_bone_marrow0.95463188
131MP0000462_abnormal_digestive_system0.94327154
132MP0004858_abnormal_nervous_system0.93404108
133MP0003868_abnormal_feces_composition0.93341841
134MP0005621_abnormal_cell_physiology0.92172011
135MP0000778_abnormal_nervous_system0.91882033
136MP0003221_abnormal_cardiomyocyte_apopto0.91777819
137MP0005360_urolithiasis0.91658805
138MP0005084_abnormal_gallbladder_morpholo0.91004867
139MP0003633_abnormal_nervous_system0.90613989
140MP0000015_abnormal_ear_pigmentation0.89930294
141MP0005647_abnormal_sex_gland0.89643481
142MP0000858_altered_metastatic_potential0.88676086
143MP0003123_paternal_imprinting0.87770724
144MP0000598_abnormal_liver_morphology0.87721756
145MP0005451_abnormal_body_composition0.87190369
146MP0004270_analgesia0.86619835
147MP0002277_abnormal_respiratory_mucosa0.86167885
148MP0002722_abnormal_immune_system0.86014994
149MP0001730_embryonic_growth_arrest0.85568870
150MP0003111_abnormal_nucleus_morphology0.85156030
151MP0005310_abnormal_salivary_gland0.83947615
152MP0000230_abnormal_systemic_arterial0.83645857
153MP0003252_abnormal_bile_duct0.83645261
154MP0006035_abnormal_mitochondrial_morpho0.83645139
155MP0000026_abnormal_inner_ear0.83545489
156MP0005535_abnormal_body_temperature0.83275177
157MP0008004_abnormal_stomach_pH0.83039403
158MP0000955_abnormal_spinal_cord0.82724952
159MP0002066_abnormal_motor_capabilities/c0.82558183
160MP0004215_abnormal_myocardial_fiber0.82315005
161MP0003631_nervous_system_phenotype0.80894505
162MP0000609_abnormal_liver_physiology0.79451449
163MP0002970_abnormal_white_adipose0.78220354
164MP0002429_abnormal_blood_cell0.78055781
165MP0005025_abnormal_response_to0.76837693
166MP0004130_abnormal_muscle_cell0.76643287
167MP0002882_abnormal_neuron_morphology0.75560295
168MP0003656_abnormal_erythrocyte_physiolo0.75475069
169MP0001873_stomach_inflammation0.75412389
170MP0000733_abnormal_muscle_development0.74608903
171MP0008872_abnormal_physiological_respon0.74270790
172MP0005384_cellular_phenotype0.74131315
173MP0000751_myopathy0.73767417
174MP0000716_abnormal_immune_system0.73332485
175MP0002127_abnormal_cardiovascular_syste0.72152026
176MP0003866_abnormal_defecation0.72119591
177MP0005584_abnormal_enzyme/coenzyme_acti0.68509381
178MP0002118_abnormal_lipid_homeostasis0.67674163
179MP0006138_congestive_heart_failure0.66812326
180MP0000313_abnormal_cell_death0.66209237
181MP0000689_abnormal_spleen_morphology0.65482245
182MP0002249_abnormal_larynx_morphology0.65004728
183MP0004084_abnormal_cardiac_muscle0.64359405
184MP0001851_eye_inflammation0.64288507
185MP0003183_abnormal_peptide_metabolism0.64017714
186MP0003634_abnormal_glial_cell0.63323962
187MP0002080_prenatal_lethality0.63238996

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.00504510
2Centrally nucleated skeletal muscle fibers (HP:0003687)4.50477072
3Focal motor seizures (HP:0011153)4.34664861
4Myopathic facies (HP:0002058)4.07515064
5Rhabdomyolysis (HP:0003201)3.92247599
6Renal Fanconi syndrome (HP:0001994)3.75996884
7Progressive muscle weakness (HP:0003323)3.75074880
8Myoglobinuria (HP:0002913)3.61345783
9Methylmalonic acidemia (HP:0002912)3.60185907
10Hypothermia (HP:0002045)3.41336021
11Febrile seizures (HP:0002373)3.38861581
12White forelock (HP:0002211)3.37299143
13Duplicated collecting system (HP:0000081)3.36303210
14Increased hepatocellular lipid droplets (HP:0006565)3.35531567
153-Methylglutaconic aciduria (HP:0003535)3.35329572
16Patchy hypopigmentation of hair (HP:0011365)3.23428032
17Epileptic encephalopathy (HP:0200134)3.21243462
18Abnormality of the renal collecting system (HP:0004742)3.15218072
19Muscle fiber inclusion bodies (HP:0100299)3.11436186
20Abnormality of skeletal muscle fiber size (HP:0012084)3.05689574
21Increased connective tissue (HP:0009025)3.00674271
22Abnormal mitochondria in muscle tissue (HP:0008316)2.97620437
23Increased intramyocellular lipid droplets (HP:0012240)2.97271194
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.95930894
25Nemaline bodies (HP:0003798)2.95721762
26Muscle stiffness (HP:0003552)2.95575185
27Hyperventilation (HP:0002883)2.90308360
28Hepatocellular necrosis (HP:0001404)2.89268194
29Increased variability in muscle fiber diameter (HP:0003557)2.85136331
30Acute necrotizing encephalopathy (HP:0006965)2.82739539
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.81553701
32Lipid accumulation in hepatocytes (HP:0006561)2.81287866
33Conjugated hyperbilirubinemia (HP:0002908)2.81051536
34Growth hormone excess (HP:0000845)2.79074884
35Distal lower limb muscle weakness (HP:0009053)2.78187790
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.76860821
37Microvesicular hepatic steatosis (HP:0001414)2.69951352
38Progressive external ophthalmoplegia (HP:0000590)2.68695850
39Mitochondrial inheritance (HP:0001427)2.68354636
40Abnormal hair whorl (HP:0010721)2.67061764
41Vertebral compression fractures (HP:0002953)2.66559741
42Asymmetric septal hypertrophy (HP:0001670)2.63669959
43Thyroid-stimulating hormone excess (HP:0002925)2.63624498
44Chronic otitis media (HP:0000389)2.62850040
45Type 1 muscle fiber predominance (HP:0003803)2.61447965
46Scanning speech (HP:0002168)2.60888395
47Hepatic necrosis (HP:0002605)2.60484800
48Abnormality of renal resorption (HP:0011038)2.47843781
49Atrioventricular block (HP:0001678)2.45734255
50Exertional dyspnea (HP:0002875)2.42298292
51Reticulocytosis (HP:0001923)2.41012258
52Focal seizures (HP:0007359)2.40553351
53Acute encephalopathy (HP:0006846)2.38761924
54Achilles tendon contracture (HP:0001771)2.38520876
55Increased muscle lipid content (HP:0009058)2.35483782
56Increased CSF lactate (HP:0002490)2.34732283
57Ankle clonus (HP:0011448)2.34473760
58Stomach cancer (HP:0012126)2.33794661
59Bulbar palsy (HP:0001283)2.33353671
60Distal lower limb amyotrophy (HP:0008944)2.33230529
61Chronic hepatic failure (HP:0100626)2.32611396
62Blue irides (HP:0000635)2.32452567
63Bundle branch block (HP:0011710)2.32239247
64Progressive macrocephaly (HP:0004481)2.29695033
65Subaortic stenosis (HP:0001682)2.28217459
66Abnormality of the left ventricular outflow tract (HP:0011103)2.28217459
67Neuronal loss in central nervous system (HP:0002529)2.27953771
68Fair hair (HP:0002286)2.27693617
69Cerebral hemorrhage (HP:0001342)2.27281872
70Broad-based gait (HP:0002136)2.26978512
71Round ear (HP:0100830)2.26734147
72Muscle hypertrophy of the lower extremities (HP:0008968)2.26485847
73Abnormality of the Achilles tendon (HP:0005109)2.24706946
74Atrial fibrillation (HP:0005110)2.23857991
75Annular pancreas (HP:0001734)2.21073129
76Neck muscle weakness (HP:0000467)2.19545483
77Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19373231
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19208413
79Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19208413
80Progressive cerebellar ataxia (HP:0002073)2.18516397
81Abnormal atrioventricular conduction (HP:0005150)2.18469071
82Prolonged QT interval (HP:0001657)2.17124467
83Nephrogenic diabetes insipidus (HP:0009806)2.16690330
84Generalized hypopigmentation of hair (HP:0011358)2.16525019
85Deep venous thrombosis (HP:0002625)2.15125633
86EMG: neuropathic changes (HP:0003445)2.14205916
87Upper limb amyotrophy (HP:0009129)2.13476914
88Distal upper limb amyotrophy (HP:0007149)2.13476914
89Abnormality of homocysteine metabolism (HP:0010919)2.12801140
90Homocystinuria (HP:0002156)2.12801140
91Heart block (HP:0012722)2.12558454
92Testicular atrophy (HP:0000029)2.12390211
93Peripheral hypomyelination (HP:0007182)2.12334068
94Optic disc pallor (HP:0000543)2.10022803
95Congenital sensorineural hearing impairment (HP:0008527)2.08526027
96Myokymia (HP:0002411)2.08002662
97Exercise-induced muscle cramps (HP:0003710)2.06388483
98Fatigue (HP:0012378)2.05416704
99Cortical visual impairment (HP:0100704)2.03675286
100Abnormality of the foot musculature (HP:0001436)2.03095355
101Methylmalonic aciduria (HP:0012120)2.02976976
102Primary atrial arrhythmia (HP:0001692)2.02212092
103Rectal prolapse (HP:0002035)2.00029967
104Abnormality of the vitamin B12 metabolism (HP:0004341)1.98040104
105Foot dorsiflexor weakness (HP:0009027)1.98016374
106Hypercortisolism (HP:0001578)1.96986093
107Stridor (HP:0010307)1.96438784
108Pancreatic cysts (HP:0001737)1.96377346
109Hyporeflexia of lower limbs (HP:0002600)1.96345087
110Thoracic kyphosis (HP:0002942)1.95547701
111Panhypogammaglobulinemia (HP:0003139)1.95449028
112Increased serum ferritin (HP:0003281)1.94861948
113Abnormality of vitamin B metabolism (HP:0004340)1.93340972
114Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93321375
115Eczematoid dermatitis (HP:0000976)1.93252126
116Abnormality of methionine metabolism (HP:0010901)1.92125982
117Retrobulbar optic neuritis (HP:0100654)1.91477604
118Optic neuritis (HP:0100653)1.91477604
119Reduced antithrombin III activity (HP:0001976)1.89960285
120Supraventricular tachycardia (HP:0004755)1.89358177
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88730100
122Athetosis (HP:0002305)1.87080935
123Obstructive sleep apnea (HP:0002870)1.85656999
124Abnormality of the thoracic spine (HP:0100711)1.84003923
125Muscle fiber splitting (HP:0003555)1.83307083
126Atonic seizures (HP:0010819)1.82684945
127Vertebral arch anomaly (HP:0008438)1.82253940
128Gait imbalance (HP:0002141)1.82165334
129Nonprogressive disorder (HP:0003680)1.81873674
130Abnormality of DNA repair (HP:0003254)1.81790575
131Respiratory difficulties (HP:0002880)1.81786794
132Inability to walk (HP:0002540)1.81501170
133Lactic acidosis (HP:0003128)1.81247796
134Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81174667
135Calf muscle hypertrophy (HP:0008981)1.80945829
136Biconcave vertebral bodies (HP:0004586)1.80853655
137Mildly elevated creatine phosphokinase (HP:0008180)1.79677857
138Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.79451357
139Neuroendocrine neoplasm (HP:0100634)1.79066278
140Abnormal gallbladder physiology (HP:0012438)1.78833827
141Cholecystitis (HP:0001082)1.78833827
142Rimmed vacuoles (HP:0003805)1.78616304
143Generalized tonic-clonic seizures (HP:0002069)1.78441791
144Cellulitis (HP:0100658)1.78245827
145Prolonged bleeding time (HP:0003010)1.78095280
146Ulnar bowing (HP:0003031)1.77829552
147Hemorrhage of the eye (HP:0011885)1.77768054
148Ulnar deviation of the wrist (HP:0003049)1.77553138
149Protrusio acetabuli (HP:0003179)1.77110428
150External ophthalmoplegia (HP:0000544)1.76520695
151Limb dystonia (HP:0002451)1.76099177
152Supraventricular arrhythmia (HP:0005115)1.75541333
153Papilledema (HP:0001085)1.75170017
154Hand muscle atrophy (HP:0009130)1.75015380
155Elevated erythrocyte sedimentation rate (HP:0003565)1.74440906
156Acute lymphatic leukemia (HP:0006721)1.74375547
157Back pain (HP:0003418)1.73490246
158Syncope (HP:0001279)1.73353912
159Metabolic alkalosis (HP:0200114)1.72954710
160Spinal canal stenosis (HP:0003416)1.72793126
161Cerebral edema (HP:0002181)1.72279638
162Abnormality of the tricuspid valve (HP:0001702)1.72193787
163Ragged-red muscle fibers (HP:0003200)1.71285857
164Renal tubular dysfunction (HP:0000124)1.71125538
165Seborrheic dermatitis (HP:0001051)1.70770471
166Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70671573
167Difficulty climbing stairs (HP:0003551)1.70441706
168Vertigo (HP:0002321)1.70432127
169Chromsome breakage (HP:0040012)1.70332135
170EMG: myopathic abnormalities (HP:0003458)1.69949628
171Abnormality of macrophages (HP:0004311)1.68965523
172Abnormal delayed hypersensitivity skin test (HP:0002963)1.68474515
173Abnormal EKG (HP:0003115)1.68116378
174Pheochromocytoma (HP:0002666)1.67702445
175Polygenic inheritance (HP:0010982)1.67641758
176Diaphragmatic weakness (HP:0009113)1.67411627
177Truncus arteriosus (HP:0001660)1.66843284
178Obstructive lung disease (HP:0006536)1.66196531
179Chronic obstructive pulmonary disease (HP:0006510)1.66196531
180Hepatosplenomegaly (HP:0001433)1.65535215
181Male infertility (HP:0003251)1.65368877
182Petechiae (HP:0000967)1.65238344
183Prolonged partial thromboplastin time (HP:0003645)1.64485049
184J-shaped sella turcica (HP:0002680)1.63671873
185Mitral regurgitation (HP:0001653)1.62331171
186Flat acetabular roof (HP:0003180)1.61945442
187Slow saccadic eye movements (HP:0000514)1.61939346
188Abnormality of fatty-acid metabolism (HP:0004359)1.61754540
189Abnormality of reticulocytes (HP:0004312)1.60737278
190Colitis (HP:0002583)1.60228213
191Hyperacusis (HP:0010780)1.60156824
192Gout (HP:0001997)1.58619169
193Areflexia of lower limbs (HP:0002522)1.57876448
194Lower limb asymmetry (HP:0100559)1.57872231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK23.73549412
2TRIB33.52942150
3PRPF4B3.31637669
4CASK3.30084649
5MUSK3.24384433
6MAP2K73.13229531
7TNIK2.97002528
8ERN12.69427742
9TAOK32.47239602
10SCYL22.45009046
11NEK62.30710250
12INSRR2.16497847
13SMG12.13516683
14MAP2K32.03597042
15STK162.02491382
16MAP3K112.02179035
17EEF2K1.99477158
18TTN1.97811724
19DMPK1.91342633
20PIK3CA1.89037283
21NUAK11.88512429
22MST41.85969168
23TXK1.84039445
24ICK1.83626919
25GRK71.77245619
26MAP3K131.74194961
27MAP3K41.74040238
28CDK31.70434115
29ADRBK21.61429433
30SIK31.59503681
31MAP3K141.56733707
32BCKDK1.52057977
33TIE11.45374863
34FGFR41.45340684
35CAMKK21.44825622
36GRK61.42875486
37RIPK41.42179308
38MAPKAPK51.41023503
39PBK1.39319991
40TEC1.36663672
41TESK21.28756272
42STK391.27843871
43TAOK21.27151266
44ZAK1.24687842
45PKN11.24009723
46KIT1.23223462
47TESK11.22705245
48IRAK31.19902965
49BMPR21.19160946
50PDGFRA1.15558353
51OXSR11.09303767
52MARK11.08766588
53ZAP701.07427751
54BTK1.07222056
55RIPK11.07193485
56MAPK131.07041082
57JAK31.05686233
58KSR21.05513785
59CDK121.05474117
60CAMK2D1.05193975
61PRKD31.05165400
62IKBKE1.04583244
63MAP3K61.04091995
64PDPK11.02707558
65YES10.99639395
66DYRK1B0.99313854
67SYK0.98546844
68PHKG10.97909806
69PHKG20.97909806
70IRAK10.97612827
71MARK20.96835771
72MAP3K10.95818318
73MAP2K20.93036046
74PRKD20.92303457
75SGK2230.92288851
76SGK4940.92288851
77IKBKB0.91838959
78TGFBR20.90853121
79CDK190.90369365
80DAPK10.88232946
81PASK0.87287449
82PINK10.86693598
83LRRK20.86655260
84TRPM70.86458010
85ARAF0.86154179
86IRAK40.84474424
87MAP2K40.83816974
88TNK20.83465031
89CAMK2B0.82638011
90FES0.81049128
91BLK0.80951935
92CAMK10.80687216
93PIM20.79721866
94MAPK110.79462973
95PRKCE0.79110320
96NTRK10.77876602
97CDK40.77636538
98SIK20.77114863
99CAMK2A0.76910667
100CAMKK10.76048175
101TYK20.75901238
102NTRK20.75767165
103PLK20.75012908
104MAP2K60.74743121
105KDR0.74120451
106PDK10.73912158
107GRK50.73567831
108PRKG20.72779292
109MAP3K120.72639684
110EPHB10.72235897
111TBK10.69904196
112CSF1R0.69238221
113PRKCQ0.69027029
114GRK10.68784319
115PKN20.67275987
116CAMK2G0.66899988
117EPHA40.66325671
118STK380.66097492
119RPS6KB20.66066045
120STK240.65831618
121SGK20.65808768
122EPHA20.65507287
123SIK10.64806005
124RPS6KC10.63911260
125RPS6KL10.63911260
126CAMK40.63364911
127MAP3K100.62265641
128CSNK1A1L0.62247939
129WNK10.61917361
130MAPK70.61574914
131PAK60.61287946
132AKT30.60579817
133VRK20.59472047
134UHMK10.58763148
135RAF10.58513106
136NME10.58022412
137MTOR0.58011780
138MAP3K70.57933260
139NTRK30.55936885
140CDK60.55822827
141LYN0.55754417
142OBSCN0.54180276
143HIPK20.52103451
144CAMK1G0.51650079
145PTK60.51531496
146AKT20.50673147
147MAPK120.50362404
148PIK3CG0.49102165
149DYRK1A0.48112117
150MYLK0.47828179
151MAPK100.47739306
152RET0.46910399
153CSNK1G30.45778698
154IRAK20.45667885
155MAP4K10.45550092
156RPS6KA20.45541392
157CDK50.45419538
158MAP3K20.45154539
159RPS6KA50.45098754
160PRKG10.44721385
161RPS6KB10.44471709
162CDK70.44138214
163CDK80.43720522
164ALK0.43315485
165MAPK150.42832359
166BMX0.42118069
167PRKACA0.41989788
168NME20.41342399
169MAPK40.41051136
170JAK20.39687908
171TYRO30.38626710
172RPS6KA60.38577304
173PRKCH0.37955676
174FLT30.36115024
175DAPK20.35585319
176CDK11A0.35223735
177ITK0.33144262
178MAP3K80.32934131
179RPS6KA40.32186129

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.24998278
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.48658679
3Other glycan degradation_Homo sapiens_hsa005113.20797511
4Nicotine addiction_Homo sapiens_hsa050333.12788981
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.69111016
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61199111
7Fructose and mannose metabolism_Homo sapiens_hsa000512.54806690
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.43867194
9Biosynthesis of amino acids_Homo sapiens_hsa012302.38186857
10Pentose phosphate pathway_Homo sapiens_hsa000302.33107664
11Sulfur relay system_Homo sapiens_hsa041222.22819539
12Carbon metabolism_Homo sapiens_hsa012002.16278679
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14758131
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02894188
15Oxidative phosphorylation_Homo sapiens_hsa001901.95875308
16Morphine addiction_Homo sapiens_hsa050321.95133135
17Acute myeloid leukemia_Homo sapiens_hsa052211.92652999
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87708868
19Parkinsons disease_Homo sapiens_hsa050121.86096306
20Glutamatergic synapse_Homo sapiens_hsa047241.77677380
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75761151
22Serotonergic synapse_Homo sapiens_hsa047261.73679169
23Alzheimers disease_Homo sapiens_hsa050101.69807576
24GABAergic synapse_Homo sapiens_hsa047271.69663193
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66713331
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.66201704
27Non-small cell lung cancer_Homo sapiens_hsa052231.65033598
28VEGF signaling pathway_Homo sapiens_hsa043701.64955894
29Insulin signaling pathway_Homo sapiens_hsa049101.62818543
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61944806
31Base excision repair_Homo sapiens_hsa034101.58918131
32Taste transduction_Homo sapiens_hsa047421.56287790
33Galactose metabolism_Homo sapiens_hsa000521.54265006
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53658870
35Chronic myeloid leukemia_Homo sapiens_hsa052201.52707798
36ABC transporters_Homo sapiens_hsa020101.51976756
37Histidine metabolism_Homo sapiens_hsa003401.51037375
38Cardiac muscle contraction_Homo sapiens_hsa042601.49553982
39Circadian entrainment_Homo sapiens_hsa047131.46778510
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45917544
41AMPK signaling pathway_Homo sapiens_hsa041521.44636795
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43638003
43Allograft rejection_Homo sapiens_hsa053301.38722382
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38636770
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.36711842
46mTOR signaling pathway_Homo sapiens_hsa041501.35689135
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34173769
48Sphingolipid metabolism_Homo sapiens_hsa006001.34071977
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33496759
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.31429424
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.27203052
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26887806
53Insulin resistance_Homo sapiens_hsa049311.24962750
54Arginine biosynthesis_Homo sapiens_hsa002201.23526821
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16437330
56B cell receptor signaling pathway_Homo sapiens_hsa046621.14890297
57beta-Alanine metabolism_Homo sapiens_hsa004101.14102261
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.12139643
59Long-term potentiation_Homo sapiens_hsa047201.11861183
60Glucagon signaling pathway_Homo sapiens_hsa049221.10399001
61Primary immunodeficiency_Homo sapiens_hsa053401.10382405
62Calcium signaling pathway_Homo sapiens_hsa040201.10144545
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08710062
64Autoimmune thyroid disease_Homo sapiens_hsa053201.08266773
65Steroid hormone biosynthesis_Homo sapiens_hsa001401.06667911
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05520185
67Cocaine addiction_Homo sapiens_hsa050301.05322514
68Ovarian steroidogenesis_Homo sapiens_hsa049131.04853690
69Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04113269
70Pancreatic cancer_Homo sapiens_hsa052121.02610122
71Tyrosine metabolism_Homo sapiens_hsa003501.02504647
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02157832
73Adipocytokine signaling pathway_Homo sapiens_hsa049201.02060630
74Notch signaling pathway_Homo sapiens_hsa043301.01497502
75Ether lipid metabolism_Homo sapiens_hsa005651.01015336
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98580894
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97816924
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.97316926
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94825542
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94584854
81Graft-versus-host disease_Homo sapiens_hsa053320.93805685
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92626291
83Phenylalanine metabolism_Homo sapiens_hsa003600.92396426
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.92348001
85Butanoate metabolism_Homo sapiens_hsa006500.91553527
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90465298
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90011041
88Cholinergic synapse_Homo sapiens_hsa047250.89973832
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.89000276
90Phototransduction_Homo sapiens_hsa047440.87490612
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86637802
92Insulin secretion_Homo sapiens_hsa049110.86463861
93African trypanosomiasis_Homo sapiens_hsa051430.85683273
94Steroid biosynthesis_Homo sapiens_hsa001000.85526626
95Vitamin digestion and absorption_Homo sapiens_hsa049770.85289697
96Peroxisome_Homo sapiens_hsa041460.85020076
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85018708
98Propanoate metabolism_Homo sapiens_hsa006400.84415614
99Salivary secretion_Homo sapiens_hsa049700.82086150
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81321874
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80347816
102Arginine and proline metabolism_Homo sapiens_hsa003300.78697545
103Circadian rhythm_Homo sapiens_hsa047100.77579270
104Inositol phosphate metabolism_Homo sapiens_hsa005620.76873641
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76780567
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76176580
107Endometrial cancer_Homo sapiens_hsa052130.75765833
108Sulfur metabolism_Homo sapiens_hsa009200.75710295
109Huntingtons disease_Homo sapiens_hsa050160.75149460
110Tryptophan metabolism_Homo sapiens_hsa003800.74790169
111Fatty acid metabolism_Homo sapiens_hsa012120.74789827
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74608673
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74546202
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74339223
115Dilated cardiomyopathy_Homo sapiens_hsa054140.73860973
116Endocytosis_Homo sapiens_hsa041440.73576290
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73160440
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72260033
119Olfactory transduction_Homo sapiens_hsa047400.72162155
120Pyruvate metabolism_Homo sapiens_hsa006200.71792572
121Arachidonic acid metabolism_Homo sapiens_hsa005900.71753787
122ErbB signaling pathway_Homo sapiens_hsa040120.71695546
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70358025
124GnRH signaling pathway_Homo sapiens_hsa049120.69674801
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69633424
126Thyroid cancer_Homo sapiens_hsa052160.68759766
127N-Glycan biosynthesis_Homo sapiens_hsa005100.67960573
128Retinol metabolism_Homo sapiens_hsa008300.67742299
129Linoleic acid metabolism_Homo sapiens_hsa005910.67741976
130Glioma_Homo sapiens_hsa052140.67403189
131Prion diseases_Homo sapiens_hsa050200.67186338
132Rheumatoid arthritis_Homo sapiens_hsa053230.66590337
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66127461
134Choline metabolism in cancer_Homo sapiens_hsa052310.65879827
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.65311365
136Bile secretion_Homo sapiens_hsa049760.64641989
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64180638
138Staphylococcus aureus infection_Homo sapiens_hsa051500.63069072
139Renin secretion_Homo sapiens_hsa049240.62669376
140Amphetamine addiction_Homo sapiens_hsa050310.59543155
141Type I diabetes mellitus_Homo sapiens_hsa049400.58229145
142Hematopoietic cell lineage_Homo sapiens_hsa046400.57208449
143Spliceosome_Homo sapiens_hsa030400.56130958
144mRNA surveillance pathway_Homo sapiens_hsa030150.55427845
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55251980
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.55150833
147Long-term depression_Homo sapiens_hsa047300.54705979
148Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54061957
149Gastric acid secretion_Homo sapiens_hsa049710.53806674
150Regulation of autophagy_Homo sapiens_hsa041400.53720974
151Prolactin signaling pathway_Homo sapiens_hsa049170.53501015
152Synaptic vesicle cycle_Homo sapiens_hsa047210.51833645
153Leukocyte transendothelial migration_Homo sapiens_hsa046700.51764051
154Dopaminergic synapse_Homo sapiens_hsa047280.50664962
155cAMP signaling pathway_Homo sapiens_hsa040240.50329355
156Fatty acid degradation_Homo sapiens_hsa000710.49025494
157Metabolic pathways_Homo sapiens_hsa011000.48550821
158Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48398178
159Asthma_Homo sapiens_hsa053100.47987172
160Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47881610
161Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47852428
162Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47432170
163Vitamin B6 metabolism_Homo sapiens_hsa007500.47126067
164Lysosome_Homo sapiens_hsa041420.45984616
165Bladder cancer_Homo sapiens_hsa052190.45483422
166T cell receptor signaling pathway_Homo sapiens_hsa046600.45481760
167Pancreatic secretion_Homo sapiens_hsa049720.44310239
168Viral myocarditis_Homo sapiens_hsa054160.43661060
169Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43414394
170Osteoclast differentiation_Homo sapiens_hsa043800.42913681
171Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42472570
172Hepatitis C_Homo sapiens_hsa051600.41797595
173Leishmaniasis_Homo sapiens_hsa051400.41084915
174Colorectal cancer_Homo sapiens_hsa052100.39004115
175Shigellosis_Homo sapiens_hsa051310.37266717
176Ribosome_Homo sapiens_hsa030100.36750012
177Platelet activation_Homo sapiens_hsa046110.36392867
178Starch and sucrose metabolism_Homo sapiens_hsa005000.35559402

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