RRP7BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.08183506
2base-excision repair, AP site formation (GO:0006285)4.07686621
3iron-sulfur cluster assembly (GO:0016226)3.89912794
4metallo-sulfur cluster assembly (GO:0031163)3.89912794
5DNA deamination (GO:0045006)3.88051688
6pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.78381303
7tRNA modification (GO:0006400)3.70044595
8negative regulation of B cell apoptotic process (GO:0002903)3.66953983
9GDP-mannose metabolic process (GO:0019673)3.50752472
10pyrimidine nucleotide catabolic process (GO:0006244)3.43901242
11dosage compensation (GO:0007549)3.42206732
12protein complex biogenesis (GO:0070271)3.26892505
13phosphatidylglycerol biosynthetic process (GO:0006655)3.24351920
14mitochondrial respiratory chain complex assembly (GO:0033108)3.19401958
15L-fucose catabolic process (GO:0042355)3.16938711
16fucose catabolic process (GO:0019317)3.16938711
17L-fucose metabolic process (GO:0042354)3.16938711
18L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15157908
19positive regulation of granulocyte differentiation (GO:0030854)3.15040406
20pseudouridine synthesis (GO:0001522)3.14781074
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.14771712
22NADH dehydrogenase complex assembly (GO:0010257)3.14771712
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14771712
24meiotic chromosome segregation (GO:0045132)3.09466024
25mannosylation (GO:0097502)3.07972688
26negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.02568924
27misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.02104498
28deoxyribonucleotide catabolic process (GO:0009264)2.99068775
29replication fork processing (GO:0031297)2.98285946
30negative regulation of telomere maintenance (GO:0032205)2.97046379
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96980365
32axoneme assembly (GO:0035082)2.96586287
33purine deoxyribonucleotide catabolic process (GO:0009155)2.93941667
34histone H3-K9 methylation (GO:0051567)2.89069787
35rRNA modification (GO:0000154)2.89008751
36regulation of nuclear cell cycle DNA replication (GO:0033262)2.88404634
37ubiquinone biosynthetic process (GO:0006744)2.84858391
38response to misfolded protein (GO:0051788)2.84670315
39negative regulation of DNA-templated transcription, elongation (GO:0032785)2.83656545
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82856740
41preassembly of GPI anchor in ER membrane (GO:0016254)2.82694752
42maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.82557312
43rRNA catabolic process (GO:0016075)2.81479108
44purinergic nucleotide receptor signaling pathway (GO:0035590)2.79975411
45cilium or flagellum-dependent cell motility (GO:0001539)2.79328258
46cellular response to exogenous dsRNA (GO:0071360)2.77329489
47tRNA processing (GO:0008033)2.73683572
48snRNA processing (GO:0016180)2.73009182
49DNA replication checkpoint (GO:0000076)2.73002358
50cytochrome complex assembly (GO:0017004)2.70083761
51mismatch repair (GO:0006298)2.65843611
52maturation of SSU-rRNA (GO:0030490)2.65613073
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64093083
54deoxyribose phosphate catabolic process (GO:0046386)2.62674861
55peptidyl-histidine modification (GO:0018202)2.61441011
56RNA modification (GO:0009451)2.61364800
57regulation of mitochondrial translation (GO:0070129)2.60820314
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.59779558
59negative regulation of mRNA processing (GO:0050686)2.59104740
60mRNA splice site selection (GO:0006376)2.59048539
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58339026
62establishment of mitochondrion localization (GO:0051654)2.58221445
63positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.58175973
64ribosomal small subunit assembly (GO:0000028)2.58081106
65Peyers patch development (GO:0048541)2.56881239
66mucosal-associated lymphoid tissue development (GO:0048537)2.56881239
67DNA strand renaturation (GO:0000733)2.56031202
68ubiquinone metabolic process (GO:0006743)2.55559859
69nucleosome disassembly (GO:0006337)2.55462747
70protein-DNA complex disassembly (GO:0032986)2.55462747
71pyrimidine dimer repair (GO:0006290)2.54211809
72DNA modification (GO:0006304)2.54157920
73kinetochore assembly (GO:0051382)2.54062601
74negative thymic T cell selection (GO:0045060)2.53817019
75telomere maintenance via semi-conservative replication (GO:0032201)2.52578786
76translesion synthesis (GO:0019985)2.51396946
77nucleotide-excision repair, DNA gap filling (GO:0006297)2.50858656
78respiratory chain complex IV assembly (GO:0008535)2.50646487
79transcription from RNA polymerase III promoter (GO:0006383)2.50184534
80negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.49850104
81purine deoxyribonucleotide metabolic process (GO:0009151)2.48578161
82mast cell activation involved in immune response (GO:0002279)2.48572687
83mast cell degranulation (GO:0043303)2.48572687
84DNA strand elongation involved in DNA replication (GO:0006271)2.46856200
85RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46615255
86amino acid salvage (GO:0043102)2.44804837
87L-methionine salvage (GO:0071267)2.44804837
88L-methionine biosynthetic process (GO:0071265)2.44804837
89reciprocal DNA recombination (GO:0035825)2.44005388
90reciprocal meiotic recombination (GO:0007131)2.44005388
91rRNA methylation (GO:0031167)2.41611319
922-deoxyribonucleotide metabolic process (GO:0009394)2.41400059
93snRNA metabolic process (GO:0016073)2.40962637
94negative regulation of cell aging (GO:0090344)2.40735092
95response to pheromone (GO:0019236)2.40325699
96histone H3-K9 modification (GO:0061647)2.39114068
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.37249398
98somatic diversification of immune receptors via somatic mutation (GO:0002566)2.37249398
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37100480
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37100480

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08609108
2CIITA_25753668_ChIP-Seq_RAJI_Human2.87471949
3CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.86592027
4E2F7_22180533_ChIP-Seq_HELA_Human2.70520561
5ETS1_20019798_ChIP-Seq_JURKAT_Human2.69298330
6VDR_21846776_ChIP-Seq_THP-1_Human2.69038808
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68243207
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57775015
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41423571
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29485566
11XRN2_22483619_ChIP-Seq_HELA_Human2.29464816
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25903641
13VDR_23849224_ChIP-Seq_CD4+_Human2.20976668
14GABP_19822575_ChIP-Seq_HepG2_Human2.07996075
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02573373
16P68_20966046_ChIP-Seq_HELA_Human2.01745438
17FOXP3_21729870_ChIP-Seq_TREG_Human2.01283139
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.98048613
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98021298
20MYC_22102868_ChIP-Seq_BL_Human1.97427058
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.90534361
22KDM5A_27292631_Chip-Seq_BREAST_Human1.89455561
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88043969
24ZNF274_21170338_ChIP-Seq_K562_Hela1.87990104
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86664931
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80812436
27BCL6_27268052_Chip-Seq_Bcells_Human1.79975282
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79327396
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79080790
30ELF1_20517297_ChIP-Seq_JURKAT_Human1.77491498
31IGF1R_20145208_ChIP-Seq_DFB_Human1.77484135
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.74402558
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.72035509
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.71637266
35MAF_26560356_Chip-Seq_TH2_Human1.70714272
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.66703973
37PHF8_20622854_ChIP-Seq_HELA_Human1.64009551
38EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.62751523
39TTF2_22483619_ChIP-Seq_HELA_Human1.61712355
40BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.56849626
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.55062956
42E2F1_20622854_ChIP-Seq_HELA_Human1.53769494
43DCP1A_22483619_ChIP-Seq_HELA_Human1.52243692
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51882656
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50326985
46FOXP1_21924763_ChIP-Seq_HESCs_Human1.50286144
47BCOR_27268052_Chip-Seq_Bcells_Human1.50100294
48ERA_21632823_ChIP-Seq_H3396_Human1.44691863
49MYC_18940864_ChIP-ChIP_HL60_Human1.44043800
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.42237118
51UTX_26944678_Chip-Seq_JUKART_Human1.41534241
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39775982
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.39703111
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38489161
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37278976
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36370630
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34571413
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.34525560
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33573368
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.31035692
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29635645
62IRF1_19129219_ChIP-ChIP_H3396_Human1.29432656
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27578131
64SCL_19346495_ChIP-Seq_HPC-7_Human1.25301283
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23627449
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23209597
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23113871
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23048677
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22647452
70CTCF_20526341_ChIP-Seq_ESCs_Human1.21880978
71RARB_24833708_ChIP-Seq_LIVER_Mouse1.21036236
72MAF_26560356_Chip-Seq_TH1_Human1.20364372
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19863521
74MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19618954
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19214776
76SMC4_20622854_ChIP-Seq_HELA_Human1.18140165
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18042905
78P300_27268052_Chip-Seq_Bcells_Human1.17994763
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.17309853
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15430368
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15138574
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13473805
83CTCF_26484167_Chip-Seq_Bcells_Mouse1.12399450
84CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11102241
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10934580
86LXR_22292898_ChIP-Seq_THP-1_Human1.10884771
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09474119
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07253670
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05311254
90TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04671908
91CTCF_27219007_Chip-Seq_Bcells_Human1.04420772
92DROSHA_22980978_ChIP-Seq_HELA_Human1.04237257
93CTCF_21964334_Chip-Seq_Bcells_Human1.04116839
94RAC3_21632823_ChIP-Seq_H3396_Human1.03533878
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03341725
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02950810
97EZH2_22144423_ChIP-Seq_EOC_Human1.02759790
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01540113
99CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01460109
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01329665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception2.82994895
2MP0001986_abnormal_taste_sensitivity2.81516815
3MP0010094_abnormal_chromosome_stability2.55896080
4MP0005423_abnormal_somatic_nervous2.53479567
5MP0003136_yellow_coat_color2.46104577
6MP0008058_abnormal_DNA_repair2.22147258
7MP0006292_abnormal_olfactory_placode2.21912869
8MP0008995_early_reproductive_senescence2.18280261
9MP0005645_abnormal_hypothalamus_physiol2.13248043
10MP0002736_abnormal_nociception_after1.92454733
11MP0003111_abnormal_nucleus_morphology1.88060585
12MP0002735_abnormal_chemical_nociception1.86122573
13MP0002822_catalepsy1.84437016
14MP0006276_abnormal_autonomic_nervous1.84362448
15MP0002653_abnormal_ependyma_morphology1.80695725
16MP0009278_abnormal_bone_marrow1.78738526
17MP0005174_abnormal_tail_pigmentation1.73190116
18MP0005646_abnormal_pituitary_gland1.71000053
19MP0001188_hyperpigmentation1.69560881
20MP0003693_abnormal_embryo_hatching1.65481344
21MP0003787_abnormal_imprinting1.58005193
22MP0006035_abnormal_mitochondrial_morpho1.57957597
23MP0005551_abnormal_eye_electrophysiolog1.51342422
24MP0003786_premature_aging1.48570799
25MP0005394_taste/olfaction_phenotype1.48182040
26MP0005499_abnormal_olfactory_system1.48182040
27MP0001502_abnormal_circadian_rhythm1.46250206
28MP0003763_abnormal_thymus_physiology1.38938616
29MP0001905_abnormal_dopamine_level1.37359675
30MP0009745_abnormal_behavioral_response1.34519696
31MP0004043_abnormal_pH_regulation1.34309509
32MP0009046_muscle_twitch1.34170656
33MP0004859_abnormal_synaptic_plasticity1.32873231
34MP0003635_abnormal_synaptic_transmissio1.29138980
35MP0005171_absent_coat_pigmentation1.27941810
36MP0008872_abnormal_physiological_respon1.27845937
37MP0004142_abnormal_muscle_tone1.24932771
38MP0001529_abnormal_vocalization1.21155044
39MP0002638_abnormal_pupillary_reflex1.20791037
40MP0001970_abnormal_pain_threshold1.20487888
41MP0005083_abnormal_biliary_tract1.19882072
42MP0003077_abnormal_cell_cycle1.19502767
43MP0004133_heterotaxia1.17770549
44MP0003880_abnormal_central_pattern1.15084223
45MP0002063_abnormal_learning/memory/cond1.14791434
46MP0000631_abnormal_neuroendocrine_gland1.14311288
47MP0002572_abnormal_emotion/affect_behav1.14182516
48MP0001984_abnormal_olfaction1.14035287
49MP0008877_abnormal_DNA_methylation1.13973197
50MP0008057_abnormal_DNA_replication1.12012846
51MP0005075_abnormal_melanosome_morpholog1.12006166
52MP0004381_abnormal_hair_follicle1.11594494
53MP0002733_abnormal_thermal_nociception1.10744642
54MP0002064_seizures1.07529490
55MP0005253_abnormal_eye_physiology1.07451559
56MP0006072_abnormal_retinal_apoptosis1.07296450
57MP0005671_abnormal_response_to1.06652473
58MP0002396_abnormal_hematopoietic_system1.05246190
59MP0000703_abnormal_thymus_morphology1.04597561
60MP0001346_abnormal_lacrimal_gland1.03875223
61MP0002272_abnormal_nervous_system1.03299513
62MP0004147_increased_porphyrin_level1.03177969
63MP0002398_abnormal_bone_marrow1.03037222
64MP0006036_abnormal_mitochondrial_physio1.02217869
65MP0002557_abnormal_social/conspecific_i1.01716801
66MP0001800_abnormal_humoral_immune1.01290437
67MP0002019_abnormal_tumor_incidence0.98807901
68MP0002160_abnormal_reproductive_system0.97518901
69MP0001486_abnormal_startle_reflex0.95817064
70MP0005220_abnormal_exocrine_pancreas0.93990979
71MP0003698_abnormal_male_reproductive0.93969139
72MP0000689_abnormal_spleen_morphology0.91369643
73MP0000015_abnormal_ear_pigmentation0.89262326
74MP0008789_abnormal_olfactory_epithelium0.89157196
75MP0001929_abnormal_gametogenesis0.88771696
76MP0008961_abnormal_basal_metabolism0.88098836
77MP0002067_abnormal_sensory_capabilities0.88066724
78MP0003646_muscle_fatigue0.87626186
79MP0002249_abnormal_larynx_morphology0.83960743
80MP0000716_abnormal_immune_system0.83071890
81MP0008875_abnormal_xenobiotic_pharmacok0.83001040
82MP0004924_abnormal_behavior0.82252755
83MP0005386_behavior/neurological_phenoty0.82252755
84MP0002722_abnormal_immune_system0.81308600
85MP0002420_abnormal_adaptive_immunity0.80968341
86MP0001819_abnormal_immune_cell0.78821039
87MP0001963_abnormal_hearing_physiology0.78337878
88MP0000778_abnormal_nervous_system0.77349383
89MP0002210_abnormal_sex_determination0.77222677
90MP0002752_abnormal_somatic_nervous0.77196455
91MP0001873_stomach_inflammation0.76955912
92MP0002429_abnormal_blood_cell0.75964631
93MP0004742_abnormal_vestibular_system0.74271721
94MP0002723_abnormal_immune_serum0.74154056
95MP0008007_abnormal_cellular_replicative0.73852029
96MP0002102_abnormal_ear_morphology0.73565817
97MP0001145_abnormal_male_reproductive0.73496500
98MP0000026_abnormal_inner_ear0.72814641
99MP0002009_preneoplasia0.72553484
100MP0000358_abnormal_cell_content/0.72531723

Predicted human phenotypes

RankGene SetZ-score
1Microvesicular hepatic steatosis (HP:0001414)3.75312289
2Retinal dysplasia (HP:0007973)3.12637160
3Patellar aplasia (HP:0006443)3.06189208
4Cerebellar dysplasia (HP:0007033)3.03959249
5Abnormal number of erythroid precursors (HP:0012131)3.01248338
6Panhypogammaglobulinemia (HP:0003139)3.01105649
7Aplasia/Hypoplasia of the patella (HP:0006498)2.87837939
8Congenital stationary night blindness (HP:0007642)2.83614684
9Hypoplasia of the pons (HP:0012110)2.79006772
10Type II lissencephaly (HP:0007260)2.75427957
11Attenuation of retinal blood vessels (HP:0007843)2.65008497
12Abnormality of cells of the erythroid lineage (HP:0012130)2.62577628
13Nephronophthisis (HP:0000090)2.61891210
14Absent rod-and cone-mediated responses on ERG (HP:0007688)2.55994868
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.55518492
16Hepatocellular necrosis (HP:0001404)2.54128263
17Abnormality of the pons (HP:0007361)2.53530987
18Rib fusion (HP:0000902)2.52696493
19Progressive microcephaly (HP:0000253)2.51847188
20Chronic hepatic failure (HP:0100626)2.45852728
21Pancreatic cysts (HP:0001737)2.44037356
22Reticulocytopenia (HP:0001896)2.42435397
23Abnormality of midbrain morphology (HP:0002418)2.36077678
24Molar tooth sign on MRI (HP:0002419)2.36077678
25Poikiloderma (HP:0001029)2.35657248
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30648364
27Agammaglobulinemia (HP:0004432)2.30279528
28Absent thumb (HP:0009777)2.30121148
29Abnormality of DNA repair (HP:0003254)2.30046358
30Testicular atrophy (HP:0000029)2.28860061
31Mitochondrial inheritance (HP:0001427)2.26941000
32Severe combined immunodeficiency (HP:0004430)2.23493040
33Increased intramyocellular lipid droplets (HP:0012240)2.21586081
34Lissencephaly (HP:0001339)2.21330356
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17014544
36Abnormality of the renal medulla (HP:0100957)2.15248395
37Bony spicule pigmentary retinopathy (HP:0007737)2.14597820
38Increased CSF lactate (HP:0002490)2.13893502
39Ragged-red muscle fibers (HP:0003200)2.13369116
40Increased muscle lipid content (HP:0009058)2.12104195
41Chromsome breakage (HP:0040012)2.09313406
42Abnormal rod and cone electroretinograms (HP:0008323)2.09123721
43True hermaphroditism (HP:0010459)2.08508399
44Abnormal biliary tract physiology (HP:0012439)2.06200333
45Bile duct proliferation (HP:0001408)2.06200333
46Pancreatic fibrosis (HP:0100732)2.06085085
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04135552
48IgG deficiency (HP:0004315)2.03184097
49Optic nerve coloboma (HP:0000588)2.01664288
503-Methylglutaconic aciduria (HP:0003535)2.01652089
51Abnormality of the renal collecting system (HP:0004742)2.01418049
52Duplicated collecting system (HP:0000081)2.01184980
53Lipid accumulation in hepatocytes (HP:0006561)2.01064230
54Absent speech (HP:0001344)2.00209413
55Abnormality of the columella (HP:0009929)1.99439756
56Abnormal mitochondria in muscle tissue (HP:0008316)1.98429731
57Stomach cancer (HP:0012126)1.95527853
58Squamous cell carcinoma (HP:0002860)1.93617416
59Aplasia/Hypoplasia of the uvula (HP:0010293)1.93487831
60Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93042003
61Dicarboxylic aciduria (HP:0003215)1.93042003
62Hepatic necrosis (HP:0002605)1.92939384
63Short thumb (HP:0009778)1.92866429
64Inability to walk (HP:0002540)1.91923997
65Increased serum lactate (HP:0002151)1.91805771
66Abnormality of B cell number (HP:0010975)1.91316021
67Increased hepatocellular lipid droplets (HP:0006565)1.90195888
68Genetic anticipation (HP:0003743)1.88077960
69Methylmalonic aciduria (HP:0012120)1.87978146
70Tubulointerstitial nephritis (HP:0001970)1.87009633
71Acute lymphatic leukemia (HP:0006721)1.85285593
72Decreased central vision (HP:0007663)1.82419511
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81877380
74Abnormal protein N-linked glycosylation (HP:0012347)1.81877380
75Abnormal protein glycosylation (HP:0012346)1.81877380
76Abnormal glycosylation (HP:0012345)1.81877380
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81187144
78Abnormality of the ileum (HP:0001549)1.79132838
79Intestinal fistula (HP:0100819)1.78335934
80Protruding tongue (HP:0010808)1.78009086
81Sloping forehead (HP:0000340)1.77556941
82Meckel diverticulum (HP:0002245)1.75899183
83Medial flaring of the eyebrow (HP:0010747)1.75665986
84Clumsiness (HP:0002312)1.73282413
85B lymphocytopenia (HP:0010976)1.71209297
86Hypoplasia of the brainstem (HP:0002365)1.69783515
87Aplasia/Hypoplasia of the brainstem (HP:0007362)1.69783515
88Tented upper lip vermilion (HP:0010804)1.69308740
89Impulsivity (HP:0100710)1.69189022
90Polydipsia (HP:0001959)1.67774511
91Abnormal drinking behavior (HP:0030082)1.67774511
92Occipital encephalocele (HP:0002085)1.67467459
93Abnormality of homocysteine metabolism (HP:0010919)1.67458063
94Homocystinuria (HP:0002156)1.67458063
95Opisthotonus (HP:0002179)1.67038248
96Cystic liver disease (HP:0006706)1.66596488
97Absent radius (HP:0003974)1.65854038
98Broad distal phalanx of finger (HP:0009836)1.65827708
99High anterior hairline (HP:0009890)1.65667251
100Progressive inability to walk (HP:0002505)1.64375153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.56169692
2TLK13.22425095
3SIK23.05949787
4MAP4K22.65721251
5BCKDK2.57599517
6MAPK152.50081353
7TAOK32.45006689
8MAP4K12.22079368
9MAP2K72.15179700
10SRPK11.97453139
11TNK21.94358939
12PIM21.85797748
13WNK41.81183532
14VRK21.73448911
15FRK1.67913296
16CSNK1A1L1.61630167
17CDK121.60917531
18STK161.57297430
19ATR1.56881318
20MAP3K41.55428868
21MAPK131.53618242
22TXK1.52796403
23NUAK11.52272015
24GRK61.50086016
25TRIM281.45809657
26CSNK1G31.45232521
27RPS6KA51.41047656
28DYRK21.35408723
29NME11.35160104
30VRK11.34053988
31TESK21.34010391
32CDC71.29364940
33MAP3K111.26055163
34BTK1.18255548
35PINK11.09659095
36KDR1.07153427
37KIT1.05313433
38NTRK21.03996695
39CSNK1G21.01884369
40CSNK1G11.01026808
41CDK40.99088397
42ADRBK20.95402648
43AURKA0.95250732
44BMPR1B0.95194284
45DAPK20.94415396
46PIM10.92006970
47MAPK110.90347751
48EEF2K0.85007371
49MAP2K60.84902980
50CHEK20.84742605
51SYK0.84694458
52IKBKB0.83933391
53NEK20.83780748
54INSRR0.81544765
55MAP2K40.80118175
56CAMKK10.79511461
57CCNB10.79433019
58FES0.79063649
59ITK0.71550829
60WNK30.70444012
61RPS6KA60.69657511
62MAP3K70.69583244
63TEC0.69037855
64MATK0.68699979
65FLT30.67932173
66DAPK10.67925385
67MAPKAPK50.63468054
68IKBKE0.61946496
69PKN10.61876381
70MARK20.61399459
71BRD40.61332624
72CDK20.59229602
73MKNK10.58722296
74BLK0.58481731
75LYN0.58213212
76TBK10.56518308
77PRKAA10.56056214
78PRKCQ0.55158384
79ATM0.54585694
80CHEK10.53050202
81CAMK10.52380360
82RPS6KC10.51846673
83RPS6KL10.51846673
84PLK10.51454971
85LCK0.51140555
86MAPK120.46700859
87CSF1R0.46384478
88MARK10.46206699
89MAPK30.45145789
90MAPK80.43306238
91CAMK1D0.42171594
92PRKCI0.41984567
93CDK70.41942951
94RPS6KA10.41861680
95CAMK40.41831372
96EPHA40.41486030
97CSNK1A10.41183823
98CDK10.40318301
99CDK190.37656593
100CSNK1D0.37512853

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.46811606
2Fanconi anemia pathway_Homo sapiens_hsa034603.43612384
3Base excision repair_Homo sapiens_hsa034103.40451398
4DNA replication_Homo sapiens_hsa030303.19308061
5Homologous recombination_Homo sapiens_hsa034403.10787154
6Primary immunodeficiency_Homo sapiens_hsa053402.77175283
7RNA polymerase_Homo sapiens_hsa030202.73601219
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.59208037
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.40622228
10Ribosome_Homo sapiens_hsa030101.96081816
11Pyrimidine metabolism_Homo sapiens_hsa002401.95167500
12Nicotine addiction_Homo sapiens_hsa050331.92619564
13Spliceosome_Homo sapiens_hsa030401.89031367
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86518703
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.85037398
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83528294
17Mismatch repair_Homo sapiens_hsa034301.82309389
18Phototransduction_Homo sapiens_hsa047441.81814061
19Non-homologous end-joining_Homo sapiens_hsa034501.79510752
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.62653441
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62619341
22RNA degradation_Homo sapiens_hsa030181.58188316
23Systemic lupus erythematosus_Homo sapiens_hsa053221.55811329
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55797522
25Asthma_Homo sapiens_hsa053101.47997656
26Purine metabolism_Homo sapiens_hsa002301.38557282
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36558262
28RNA transport_Homo sapiens_hsa030131.36049768
29Nucleotide excision repair_Homo sapiens_hsa034201.32295295
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31313473
31Taste transduction_Homo sapiens_hsa047421.28434537
32Alcoholism_Homo sapiens_hsa050341.27047174
33Lysine degradation_Homo sapiens_hsa003101.25271614
34mRNA surveillance pathway_Homo sapiens_hsa030151.15572502
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.13593256
36Oxidative phosphorylation_Homo sapiens_hsa001901.13282028
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12067071
38Basal transcription factors_Homo sapiens_hsa030221.08129778
39Parkinsons disease_Homo sapiens_hsa050121.07689283
40Allograft rejection_Homo sapiens_hsa053301.04889422
41Morphine addiction_Homo sapiens_hsa050321.03657126
42One carbon pool by folate_Homo sapiens_hsa006701.02257145
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01947925
44Olfactory transduction_Homo sapiens_hsa047401.00516976
45Autoimmune thyroid disease_Homo sapiens_hsa053200.99298806
46Huntingtons disease_Homo sapiens_hsa050160.98544278
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98475346
48Butanoate metabolism_Homo sapiens_hsa006500.96814610
49Graft-versus-host disease_Homo sapiens_hsa053320.95320686
50Regulation of autophagy_Homo sapiens_hsa041400.93781193
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90799269
52ABC transporters_Homo sapiens_hsa020100.85383729
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83674393
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77755047
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77689702
56Fructose and mannose metabolism_Homo sapiens_hsa000510.74810653
57Peroxisome_Homo sapiens_hsa041460.74554172
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74428300
59Type I diabetes mellitus_Homo sapiens_hsa049400.74268370
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.73154502
61Ether lipid metabolism_Homo sapiens_hsa005650.72949002
62Linoleic acid metabolism_Homo sapiens_hsa005910.70910406
63GABAergic synapse_Homo sapiens_hsa047270.70876615
64Herpes simplex infection_Homo sapiens_hsa051680.69630206
65Selenocompound metabolism_Homo sapiens_hsa004500.63636284
66Epstein-Barr virus infection_Homo sapiens_hsa051690.56536589
67Cell cycle_Homo sapiens_hsa041100.55864745
68Circadian entrainment_Homo sapiens_hsa047130.55378202
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53593990
70Calcium signaling pathway_Homo sapiens_hsa040200.50503818
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49650060
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47793867
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47415096
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47273703
75Metabolic pathways_Homo sapiens_hsa011000.46178248
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44819232
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42414254
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.40633934
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39416035
80Glutamatergic synapse_Homo sapiens_hsa047240.38365955
81Circadian rhythm_Homo sapiens_hsa047100.37609887
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34878838
83Cocaine addiction_Homo sapiens_hsa050300.33833346
84Hedgehog signaling pathway_Homo sapiens_hsa043400.32030773
85Alzheimers disease_Homo sapiens_hsa050100.32013937
86Viral carcinogenesis_Homo sapiens_hsa052030.30945766
87Ovarian steroidogenesis_Homo sapiens_hsa049130.30332090
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.29275560
89Antigen processing and presentation_Homo sapiens_hsa046120.28039794
90Synaptic vesicle cycle_Homo sapiens_hsa047210.27241026
91Dopaminergic synapse_Homo sapiens_hsa047280.26916000
92Cholinergic synapse_Homo sapiens_hsa047250.24369756
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23734729
94Salivary secretion_Homo sapiens_hsa049700.22517214
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21354446
96Nitrogen metabolism_Homo sapiens_hsa009100.20514838
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19301787
98Hematopoietic cell lineage_Homo sapiens_hsa046400.19228015
99Glycerolipid metabolism_Homo sapiens_hsa005610.18601588
100Biosynthesis of amino acids_Homo sapiens_hsa012300.18551214

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