RRP36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RRP36 functions at an early stage in the processing of 35S preribosomal RNA into the mature 18S species (Gerus et al., 2010 [PubMed 20038530]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.89268171
2nuclear pore complex assembly (GO:0051292)4.82989253
3mitotic chromosome condensation (GO:0007076)4.82963405
4ribosomal small subunit assembly (GO:0000028)4.53181679
5formation of translation preinitiation complex (GO:0001731)4.51663202
6DNA strand elongation involved in DNA replication (GO:0006271)4.35405130
7nucleobase biosynthetic process (GO:0046112)4.28578777
8purine nucleobase biosynthetic process (GO:0009113)4.25071066
9nuclear pore organization (GO:0006999)4.22580578
10regulation of translational fidelity (GO:0006450)4.18414622
11proteasome assembly (GO:0043248)4.16179016
12DNA strand elongation (GO:0022616)4.14012655
13maturation of SSU-rRNA (GO:0030490)4.10304791
14telomere maintenance via semi-conservative replication (GO:0032201)4.08421069
15protein localization to chromosome, centromeric region (GO:0071459)4.05317040
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.03467924
17regulation of translational termination (GO:0006449)4.03381618
18heterochromatin organization (GO:0070828)4.02993256
19ribosome biogenesis (GO:0042254)3.94865817
20DNA replication initiation (GO:0006270)3.87719819
21mitotic sister chromatid segregation (GO:0000070)3.86969908
22nucleobase-containing small molecule interconversion (GO:0015949)3.86338825
23ribosome assembly (GO:0042255)3.76668971
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67413533
25* ribonucleoprotein complex biogenesis (GO:0022613)3.66703022
26IMP biosynthetic process (GO:0006188)3.63701187
27telomere maintenance via recombination (GO:0000722)3.59252881
28protein maturation by protein folding (GO:0022417)3.59160221
29establishment of integrated proviral latency (GO:0075713)3.58035138
30pore complex assembly (GO:0046931)3.57741740
31ribosomal large subunit biogenesis (GO:0042273)3.55070786
32sister chromatid segregation (GO:0000819)3.52218983
33rRNA modification (GO:0000154)3.51901842
34DNA unwinding involved in DNA replication (GO:0006268)3.49887558
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48970031
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48959660
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48153875
38COPI coating of Golgi vesicle (GO:0048205)3.43827232
39Golgi transport vesicle coating (GO:0048200)3.43827232
40regulation of mammary gland epithelial cell proliferation (GO:0033599)3.43065167
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.42679593
42viral transcription (GO:0019083)3.42298976
43DNA replication checkpoint (GO:0000076)3.42168915
44* rRNA processing (GO:0006364)3.41734300
45folic acid-containing compound biosynthetic process (GO:0009396)3.41240210
46pseudouridine synthesis (GO:0001522)3.40210091
47protein complex localization (GO:0031503)3.38683147
48mitotic metaphase plate congression (GO:0007080)3.37527805
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.36500700
50termination of RNA polymerase III transcription (GO:0006386)3.36500700
51intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.36479785
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.36479785
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36086496
54negative regulation of ligase activity (GO:0051352)3.36086496
55signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34814028
56signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34814028
57signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34814028
58translational termination (GO:0006415)3.34419583
59* ribosomal small subunit biogenesis (GO:0042274)3.32919087
60IMP metabolic process (GO:0046040)3.32800097
61* rRNA metabolic process (GO:0016072)3.31247259
62signal transduction involved in DNA integrity checkpoint (GO:0072401)3.29493710
63signal transduction involved in DNA damage checkpoint (GO:0072422)3.29493710
64translational initiation (GO:0006413)3.27229382
65negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.25245903
66mitotic recombination (GO:0006312)3.25197279
67signal transduction involved in cell cycle checkpoint (GO:0072395)3.23447438
68spliceosomal snRNP assembly (GO:0000387)3.19902704
69translational elongation (GO:0006414)3.19199231
70regulation of cellular amino acid metabolic process (GO:0006521)3.18464925
71viral mRNA export from host cell nucleus (GO:0046784)3.18082375
72telomere maintenance via telomere lengthening (GO:0010833)3.17135288
73regulation of mitochondrial translation (GO:0070129)3.17066480
74protein localization to kinetochore (GO:0034501)3.15635285
75L-serine metabolic process (GO:0006563)3.15570385
76folic acid metabolic process (GO:0046655)3.12582357
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.12013335
78CENP-A containing nucleosome assembly (GO:0034080)3.11087431
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.10872603
80transcription-coupled nucleotide-excision repair (GO:0006283)3.10127271
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.10096455
82negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.09502253
83proline biosynthetic process (GO:0006561)3.08990402
84mitotic sister chromatid cohesion (GO:0007064)3.07767223
85cellular protein complex localization (GO:0034629)3.06483231
86establishment of viral latency (GO:0019043)3.06033324
87spliceosomal tri-snRNP complex assembly (GO:0000244)3.04925503
88chromosome condensation (GO:0030261)3.04576850
89mitotic nuclear envelope disassembly (GO:0007077)3.04422225
90cullin deneddylation (GO:0010388)3.03074100
91chromatin remodeling at centromere (GO:0031055)3.01841444
92establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01469551
93positive regulation of ligase activity (GO:0051351)3.01142970
94protein deneddylation (GO:0000338)3.01113066
95cell cycle G1/S phase transition (GO:0044843)3.00843059
96G1/S transition of mitotic cell cycle (GO:0000082)3.00843059
97nucleotide-excision repair, DNA gap filling (GO:0006297)2.99980212
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97072988
99transcription from RNA polymerase I promoter (GO:0006360)2.96903994
100SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.95859240
101cellular protein complex disassembly (GO:0043624)2.95771796
102viral life cycle (GO:0019058)2.95509361
103* cellular component biogenesis (GO:0044085)2.94885477
104regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93515438
105termination of RNA polymerase I transcription (GO:0006363)2.93351608
106maturation of 5.8S rRNA (GO:0000460)2.92909922
107translation (GO:0006412)2.92737213
108antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.91825769
109mitochondrial fusion (GO:0008053)2.91613441
110somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91284248
111somatic hypermutation of immunoglobulin genes (GO:0016446)2.91284248
112rRNA methylation (GO:0031167)2.90021508
1137-methylguanosine mRNA capping (GO:0006370)2.88753440
114cotranslational protein targeting to membrane (GO:0006613)2.87592521
115nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85913190
116protein targeting to ER (GO:0045047)2.85730164
117positive regulation of cell cycle arrest (GO:0071158)2.85483711
118DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.84126597
119DNA replication-dependent nucleosome organization (GO:0034723)2.82046884
120DNA replication-dependent nucleosome assembly (GO:0006335)2.82046884
121metaphase plate congression (GO:0051310)2.79469075
1227-methylguanosine RNA capping (GO:0009452)2.79243880
123RNA capping (GO:0036260)2.79243880
124regulation of ubiquitin-protein transferase activity (GO:0051438)2.78691710
125DNA packaging (GO:0006323)2.75696081
126rRNA transcription (GO:0009303)2.75190101
127protein complex disassembly (GO:0043241)2.74857460
128transcription elongation from RNA polymerase I promoter (GO:0006362)2.73953197
129DNA duplex unwinding (GO:0032508)2.73479057
130protein localization to endoplasmic reticulum (GO:0070972)2.72895867
131kinetochore organization (GO:0051383)2.72855986
132membrane disassembly (GO:0030397)2.72623330
133nuclear envelope disassembly (GO:0051081)2.72623330
134mitotic nuclear envelope reassembly (GO:0007084)2.72569190
135nuclear envelope reassembly (GO:0031468)2.72569190
136regulation of RNA export from nucleus (GO:0046831)2.72535951
137L-methionine salvage (GO:0071267)2.71161976
138L-methionine biosynthetic process (GO:0071265)2.71161976
139amino acid salvage (GO:0043102)2.71161976
140positive regulation of chromosome segregation (GO:0051984)2.69187522
141establishment of chromosome localization (GO:0051303)2.68866954
142positive regulation of DNA-dependent DNA replication (GO:2000105)2.66805709
143regulation of mitotic spindle organization (GO:0060236)2.65539340
144protein export from nucleus (GO:0006611)2.64062632
145regulation of early endosome to late endosome transport (GO:2000641)2.62798993
146histone arginine methylation (GO:0034969)2.62415442
147macromolecular complex disassembly (GO:0032984)2.60620297
148histone H2B ubiquitination (GO:0033523)2.60578255
149chromatin assembly (GO:0031497)2.60055607
150negative regulation of mRNA processing (GO:0050686)2.57394866
151DNA geometric change (GO:0032392)2.56949642
152regulation of spindle organization (GO:0090224)2.56613110
153DNA conformation change (GO:0071103)2.56465436
154positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.56301442
155regulation of translational elongation (GO:0006448)2.54724934
156negative regulation of RNA splicing (GO:0033119)2.54281667
157pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.54159732
158nuclear envelope organization (GO:0006998)2.51288984
159peptidyl-arginine omega-N-methylation (GO:0035247)2.50487713
160chromatin assembly or disassembly (GO:0006333)2.49933280

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.02223035
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.00670685
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74448722
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22508876
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15909309
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.07466784
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.01133583
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88138494
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.87495832
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78947869
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75608559
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71885112
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69669748
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.61022958
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38556717
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34778029
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28067144
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24237189
19XRN2_22483619_ChIP-Seq_HELA_Human2.22942621
20E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19517088
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18748796
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.18388904
23VDR_23849224_ChIP-Seq_CD4+_Human2.17348077
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13495677
25ZNF263_19887448_ChIP-Seq_K562_Human2.13208937
26FOXP3_21729870_ChIP-Seq_TREG_Human1.96823617
27DCP1A_22483619_ChIP-Seq_HELA_Human1.96819386
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93743614
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88844629
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86360307
31GABP_19822575_ChIP-Seq_HepG2_Human1.86224691
32* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85867084
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85260930
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.82819081
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.81764338
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.81080122
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74406378
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70442218
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67779420
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65707385
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65460729
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64428694
43CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56838513
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55211834
45TTF2_22483619_ChIP-Seq_HELA_Human1.55093779
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54841416
47AR_21909140_ChIP-Seq_LNCAP_Human1.53583985
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53158140
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51399920
50ELK1_19687146_ChIP-ChIP_HELA_Human1.50639403
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49971687
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49193020
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48094887
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47372850
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45946528
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44309744
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.43913969
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36755561
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35799941
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34280908
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33828012
62CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33611718
63KDM5A_27292631_Chip-Seq_BREAST_Human1.33485413
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.33047654
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30959181
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30437041
67RACK7_27058665_Chip-Seq_MCF-7_Human1.30394618
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29678357
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29645434
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28967909
71CIITA_25753668_ChIP-Seq_RAJI_Human1.28332520
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27478978
73MYC_22102868_ChIP-Seq_BL_Human1.27048220
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26558684
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25987141
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.24988894
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.24538868
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20551185
79EGR1_19374776_ChIP-ChIP_THP-1_Human1.19560260
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18943784
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18035004
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17867223
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16918120
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16582175
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15819789
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15045094
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12737109
88ATF3_27146783_Chip-Seq_COLON_Human1.11828529
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10471708
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.09504195
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09410928
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.08530604
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07252870
94TFEB_21752829_ChIP-Seq_HELA_Human1.05970399
95LXR_22292898_ChIP-Seq_THP-1_Human1.04456114
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03796614
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03628248
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03454513
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03441225
100SPI1_23547873_ChIP-Seq_NB4_Human1.02905224
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02355600
102CHD1_26751641_Chip-Seq_LNCaP_Human1.01959349
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01636114
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00705660
105TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00501116
106SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99436921
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98424343
108TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98383257
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98098683
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97364238
111OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97149079
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96875431
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96707587
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96307708
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95726903
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95601286
117VDR_21846776_ChIP-Seq_THP-1_Human0.95336924
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95318055
119SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95289728
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95223047
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93635234
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93375152
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93030438
124KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93030438
125KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93030438
126PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92469784
127KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92169081
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91773563
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87796000
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87565835
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87509616

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.67028137
2MP0004957_abnormal_blastocyst_morpholog4.13027685
3MP0003806_abnormal_nucleotide_metabolis3.89311598
4MP0003111_abnormal_nucleus_morphology3.74560293
5MP0010094_abnormal_chromosome_stability3.63768518
6MP0008057_abnormal_DNA_replication3.48824815
7MP0003077_abnormal_cell_cycle3.44120946
8MP0002877_abnormal_melanocyte_morpholog3.18923978
9MP0008058_abnormal_DNA_repair2.78732395
10MP0008007_abnormal_cellular_replicative2.63834139
11MP0004185_abnormal_adipocyte_glucose2.61290582
12MP0005623_abnormal_meninges_morphology2.44239871
13MP0002396_abnormal_hematopoietic_system2.38562297
14MP0004233_abnormal_muscle_weight2.32064384
15MP0008932_abnormal_embryonic_tissue2.24601705
16MP0003186_abnormal_redox_activity2.24449408
17MP0005257_abnormal_intraocular_pressure2.15270227
18MP0010234_abnormal_vibrissa_follicle1.96991289
19MP0001730_embryonic_growth_arrest1.93187692
20MP0003718_maternal_effect1.91742370
21MP0009333_abnormal_splenocyte_physiolog1.86157103
22MP0000350_abnormal_cell_proliferation1.83412741
23MP0000537_abnormal_urethra_morphology1.79973152
24MP0003786_premature_aging1.79621385
25MP0002132_abnormal_respiratory_system1.79405857
26MP0005076_abnormal_cell_differentiation1.74147439
27MP0000490_abnormal_crypts_of1.70118835
28MP0005501_abnormal_skin_physiology1.69495736
29MP0010352_gastrointestinal_tract_polyps1.65585907
30MP0009840_abnormal_foam_cell1.57837738
31MP0001545_abnormal_hematopoietic_system1.54418708
32MP0005397_hematopoietic_system_phenotyp1.54418708
33MP0009379_abnormal_foot_pigmentation1.54192691
34MP0010307_abnormal_tumor_latency1.52574914
35MP0003123_paternal_imprinting1.51898869
36MP0002796_impaired_skin_barrier1.50120041
37MP0003763_abnormal_thymus_physiology1.44267042
38MP0009053_abnormal_anal_canal1.42702335
39MP0004858_abnormal_nervous_system1.40386953
40MP0001697_abnormal_embryo_size1.38339193
41MP0002019_abnormal_tumor_incidence1.38229182
42MP0009672_abnormal_birth_weight1.36808852
43MP0003453_abnormal_keratinocyte_physiol1.36746144
44MP0001835_abnormal_antigen_presentation1.36465165
45MP0001849_ear_inflammation1.35433744
46MP0004272_abnormal_basement_membrane1.34017166
47MP0005380_embryogenesis_phenotype1.33872425
48MP0001672_abnormal_embryogenesis/_devel1.33872425
49MP0000313_abnormal_cell_death1.33286658
50MP0002163_abnormal_gland_morphology1.31934366
51MP0002080_prenatal_lethality1.31341398
52MP0000733_abnormal_muscle_development1.29384095
53MP0000689_abnormal_spleen_morphology1.27610707
54MP0004808_abnormal_hematopoietic_stem1.25931247
55MP0006036_abnormal_mitochondrial_physio1.25688032
56MP0002722_abnormal_immune_system1.23405459
57MP0001853_heart_inflammation1.23045364
58MP0001661_extended_life_span1.21615390
59MP0005058_abnormal_lysosome_morphology1.20562462
60MP0003984_embryonic_growth_retardation1.20365711
61MP0002398_abnormal_bone_marrow1.18153811
62MP0008438_abnormal_cutaneous_collagen1.17740624
63MP0000750_abnormal_muscle_regeneration1.16500576
64MP0002088_abnormal_embryonic_growth/wei1.15722990
65MP0010030_abnormal_orbit_morphology1.15686611
66MP0009785_altered_susceptibility_to1.14863310
67MP0000358_abnormal_cell_content/1.14485452
68MP0000685_abnormal_immune_system1.13627719
69MP0001348_abnormal_lacrimal_gland1.12956318
70MP0000003_abnormal_adipose_tissue1.12309063
71MP0009697_abnormal_copulation1.11388506
72MP0005023_abnormal_wound_healing1.08710113
73MP0002697_abnormal_eye_size1.08646054
74MP0002086_abnormal_extraembryonic_tissu1.07993395
75MP0000858_altered_metastatic_potential1.07496501
76MP0001764_abnormal_homeostasis1.07096253
77MP0002429_abnormal_blood_cell1.06988487
78MP0002085_abnormal_embryonic_tissue1.06543571
79MP0002060_abnormal_skin_morphology1.05305150
80MP0006035_abnormal_mitochondrial_morpho1.04797661
81MP0005075_abnormal_melanosome_morpholog1.04091057
82MP0005266_abnormal_metabolism1.03855746
83MP0002092_abnormal_eye_morphology0.99814232
84MP0003656_abnormal_erythrocyte_physiolo0.97669862
85MP0003566_abnormal_cell_adhesion0.97134591
86MP0000703_abnormal_thymus_morphology0.95877673
87MP0003567_abnormal_fetal_cardiomyocyte0.95112197
88MP0008877_abnormal_DNA_methylation0.95025413
89MP0003221_abnormal_cardiomyocyte_apopto0.94751847
90MP0000428_abnormal_craniofacial_morphol0.94528466
91MP0000716_abnormal_immune_system0.94474715
92MP0000678_abnormal_parathyroid_gland0.93904706
93MP0001800_abnormal_humoral_immune0.93537544
94MP0002405_respiratory_system_inflammati0.91991306
95MP0004133_heterotaxia0.91507884
96MP0001216_abnormal_epidermal_layer0.91135433
97MP0005197_abnormal_uvea_morphology0.90411646
98MP0002089_abnormal_postnatal_growth/wei0.89662273
99MP0000759_abnormal_skeletal_muscle0.89615879
100MP0003385_abnormal_body_wall0.89095994
101MP0004197_abnormal_fetal_growth/weight/0.88799566
102MP0003436_decreased_susceptibility_to0.87996262
103MP0001881_abnormal_mammary_gland0.87950378
104MP0002452_abnormal_antigen_presenting0.86941788
105MP0003950_abnormal_plasma_membrane0.86486429
106MP0000762_abnormal_tongue_morphology0.86466437
107MP0002084_abnormal_developmental_patter0.85865437
108MP0005025_abnormal_response_to0.84849468
109MP0005671_abnormal_response_to0.84397381
110MP0009278_abnormal_bone_marrow0.84333444
111MP0003942_abnormal_urinary_system0.83889169
112MP0005375_adipose_tissue_phenotype0.82964527
113MP0005666_abnormal_adipose_tissue0.82878344
114MP0001819_abnormal_immune_cell0.82824216
115MP0002420_abnormal_adaptive_immunity0.82468680
116MP0001915_intracranial_hemorrhage0.82287404
117MP0000598_abnormal_liver_morphology0.80204091
118MP0003091_abnormal_cell_migration0.79813277
119MP0001727_abnormal_embryo_implantation0.79728663
120MP0000747_muscle_weakness0.78122852
121MP0001293_anophthalmia0.77797663
122MP0005408_hypopigmentation0.77659307
123MP0002269_muscular_atrophy0.76625520
124MP0008260_abnormal_autophagy0.76286092
125MP0003937_abnormal_limbs/digits/tail_de0.76190550
126MP0001346_abnormal_lacrimal_gland0.75690278
127MP0006082_CNS_inflammation0.75199359
128MP0000627_abnormal_mammary_gland0.74539697
129MP0002723_abnormal_immune_serum0.73983607
130MP0003315_abnormal_perineum_morphology0.73630455
131MP0001186_pigmentation_phenotype0.73475796
132MP0005384_cellular_phenotype0.72218290
133MP0003941_abnormal_skin_development0.71857053
134MP0002177_abnormal_outer_ear0.71101748
135MP0002210_abnormal_sex_determination0.70942841
136MP0006292_abnormal_olfactory_placode0.70671910
137MP0001542_abnormal_bone_strength0.69780554
138MP0002111_abnormal_tail_morphology0.68607377
139MP0001145_abnormal_male_reproductive0.67515387
140MP0004264_abnormal_extraembryonic_tissu0.67445280
141MP0001119_abnormal_female_reproductive0.67424180
142MP0005621_abnormal_cell_physiology0.66755403
143MP0010155_abnormal_intestine_physiology0.66535726
144MP0002653_abnormal_ependyma_morphology0.66095555
145MP0005451_abnormal_body_composition0.64603127
146MP0000477_abnormal_intestine_morphology0.64473136
147MP0005376_homeostasis/metabolism_phenot0.63989108
148MP0002148_abnormal_hypersensitivity_rea0.63514353
149MP0003448_altered_tumor_morphology0.62608454
150MP0003705_abnormal_hypodermis_morpholog0.61798307
151MP0005000_abnormal_immune_tolerance0.60773990

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.21036569
2Cerebral hypomyelination (HP:0006808)3.87112723
3Abnormality of cells of the erythroid lineage (HP:0012130)3.75327106
4Breast hypoplasia (HP:0003187)3.61941986
5Aplastic anemia (HP:0001915)3.61548077
6Abnormal number of erythroid precursors (HP:0012131)3.58681951
7Reticulocytopenia (HP:0001896)3.52242201
8Oral leukoplakia (HP:0002745)3.49919933
9Degeneration of anterior horn cells (HP:0002398)3.33232411
10Abnormality of the anterior horn cell (HP:0006802)3.33232411
11Achilles tendon contracture (HP:0001771)3.22440783
12Premature rupture of membranes (HP:0001788)3.16076444
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.14377431
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.14377431
15Multiple enchondromatosis (HP:0005701)3.04664985
16Rough bone trabeculation (HP:0100670)3.04647271
17Hyperacusis (HP:0010780)3.00286985
18Increased serum pyruvate (HP:0003542)2.95972324
19Abnormality of glycolysis (HP:0004366)2.95972324
20Carpal bone hypoplasia (HP:0001498)2.94353633
21Selective tooth agenesis (HP:0001592)2.79696324
22Abnormality of the Achilles tendon (HP:0005109)2.79081585
23Ragged-red muscle fibers (HP:0003200)2.74142669
24Microretrognathia (HP:0000308)2.72285539
25Patellar aplasia (HP:0006443)2.70123422
26Entropion (HP:0000621)2.62377448
27Progressive external ophthalmoplegia (HP:0000590)2.62248826
28Trismus (HP:0000211)2.60672692
29Aplasia/Hypoplasia of the patella (HP:0006498)2.58771864
30Agnosia (HP:0010524)2.53636497
31Increased serum lactate (HP:0002151)2.53202272
32Ulnar bowing (HP:0003031)2.52488552
33Macrocytic anemia (HP:0001972)2.50772751
34Thrombocytosis (HP:0001894)2.43400843
35Amaurosis fugax (HP:0100576)2.41688170
36Insomnia (HP:0100785)2.40126963
37Vertebral compression fractures (HP:0002953)2.38936687
38Type I transferrin isoform profile (HP:0003642)2.34560489
39Abnormality of the fetal cardiovascular system (HP:0010948)2.34183463
40Abnormal umbilical cord blood vessels (HP:0011403)2.34183463
41Single umbilical artery (HP:0001195)2.34183463
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32722860
43Meckel diverticulum (HP:0002245)2.29887151
44Asymmetry of the thorax (HP:0001555)2.29777568
45Premature graying of hair (HP:0002216)2.29673728
46Poikiloderma (HP:0001029)2.28115499
47Short nail (HP:0001799)2.27210154
48Colon cancer (HP:0003003)2.25252625
49Abnormality of the ileum (HP:0001549)2.23637014
50Abnormal trabecular bone morphology (HP:0100671)2.23006022
51Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22974493
52Medulloblastoma (HP:0002885)2.22117250
53Abnormality of pyrimidine metabolism (HP:0004353)2.21662326
54Hepatocellular necrosis (HP:0001404)2.21178380
55Aplasia/Hypoplasia involving the musculature (HP:0001460)2.20796630
56Squamous cell carcinoma (HP:0002860)2.19847421
57Ependymoma (HP:0002888)2.19671874
583-Methylglutaconic aciduria (HP:0003535)2.19265177
59Hepatic necrosis (HP:0002605)2.18850515
60Absent radius (HP:0003974)2.17900782
61Tongue fasciculations (HP:0001308)2.17556691
62Chromsome breakage (HP:0040012)2.15411346
63Septate vagina (HP:0001153)2.15251738
64Muscle fiber atrophy (HP:0100295)2.15202944
65Neoplasm of the pancreas (HP:0002894)2.15165516
66Sparse eyelashes (HP:0000653)2.14339405
67Testicular atrophy (HP:0000029)2.14132514
68Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13583203
69Bone marrow hypocellularity (HP:0005528)2.13535497
70Pallor (HP:0000980)2.11524369
71Cellular immunodeficiency (HP:0005374)2.11429877
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08559518
73Abnormality of the distal phalanges of the toes (HP:0010182)2.08530170
74Abnormality of the preputium (HP:0100587)2.08250137
75Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08171111
76Poor head control (HP:0002421)2.08169915
77Absent thumb (HP:0009777)2.08147536
78Microvesicular hepatic steatosis (HP:0001414)2.08070053
79Deviation of the thumb (HP:0009603)2.07622025
80Syringomyelia (HP:0003396)2.07102908
81Spinal cord lesions (HP:0100561)2.07102908
82Rhabdomyosarcoma (HP:0002859)2.07086477
83Pancytopenia (HP:0001876)2.06720616
84Myelodysplasia (HP:0002863)2.06195207
85Reduced antithrombin III activity (HP:0001976)2.06088263
86Abnormality of the umbilical cord (HP:0010881)2.05338237
87Elbow flexion contracture (HP:0002987)2.04816568
88Increased CSF lactate (HP:0002490)2.03954617
89Increased connective tissue (HP:0009025)2.03124072
90Aplasia involving forearm bones (HP:0009822)2.03122420
91Absent forearm bone (HP:0003953)2.03122420
92Premature ovarian failure (HP:0008209)2.02361322
93CNS hypomyelination (HP:0003429)2.00000774
94Patellar dislocation (HP:0002999)1.98401427
95Ankle contracture (HP:0006466)1.98240911
96IgM deficiency (HP:0002850)1.97976018
97Impulsivity (HP:0100710)1.97853991
98Difficulty climbing stairs (HP:0003551)1.97827896
99Type 2 muscle fiber atrophy (HP:0003554)1.97592729
100Abnormalities of placenta or umbilical cord (HP:0001194)1.97018069
101Lymphoma (HP:0002665)1.96530281
102Secondary amenorrhea (HP:0000869)1.95092734
10311 pairs of ribs (HP:0000878)1.95067827
104Prolonged neonatal jaundice (HP:0006579)1.94048118
105Proximal placement of thumb (HP:0009623)1.93221255
106Abnormality of chromosome stability (HP:0003220)1.93099680
107Petechiae (HP:0000967)1.92912706
108Overlapping toe (HP:0001845)1.92481988
109Renal duplication (HP:0000075)1.92070735
110Distal lower limb amyotrophy (HP:0008944)1.91021443
111Muscle fibrillation (HP:0010546)1.90931605
112Ureteral duplication (HP:0000073)1.90525940
113Patent foramen ovale (HP:0001655)1.90418416
114Long palpebral fissure (HP:0000637)1.89582521
115Generalized amyotrophy (HP:0003700)1.89358494
116Abnormality of the tricuspid valve (HP:0001702)1.87003288
117Abnormality of the phalanges of the hallux (HP:0010057)1.86867079
118CNS demyelination (HP:0007305)1.86046938
119Sparse lateral eyebrow (HP:0005338)1.84318147
120Overriding aorta (HP:0002623)1.83151007
121Missing ribs (HP:0000921)1.82987405
122Basal cell carcinoma (HP:0002671)1.82979888
123Broad distal phalanx of finger (HP:0009836)1.82936657
124Spinal rigidity (HP:0003306)1.82234637
125Deep palmar crease (HP:0006191)1.81529281
126Nausea (HP:0002018)1.81206717
127Progressive muscle weakness (HP:0003323)1.80727284
128Shoulder girdle muscle weakness (HP:0003547)1.80187996
129Abnormality of T cell physiology (HP:0011840)1.79068381
130Elevated erythrocyte sedimentation rate (HP:0003565)1.78047144
131Cortical dysplasia (HP:0002539)1.77240437
132Mitochondrial inheritance (HP:0001427)1.77232478
133Increased nuchal translucency (HP:0010880)1.76827569
134Cutaneous melanoma (HP:0012056)1.75759530
135Calcaneovalgus deformity (HP:0001848)1.75734825
136Spastic diplegia (HP:0001264)1.75694060
137Megaloblastic anemia (HP:0001889)1.74466740
138Increased hepatocellular lipid droplets (HP:0006565)1.74464665
139Glossoptosis (HP:0000162)1.74327517
140Exertional dyspnea (HP:0002875)1.74023526
141Protrusio acetabuli (HP:0003179)1.73746333
142Lipid accumulation in hepatocytes (HP:0006561)1.73536140
143Disproportionate tall stature (HP:0001519)1.73068533
144Cleft eyelid (HP:0000625)1.72458119
145Abnormality of the calcaneus (HP:0008364)1.71826005
146Postnatal microcephaly (HP:0005484)1.71644368
147Deformed tarsal bones (HP:0008119)1.71611749
148Aplasia/Hypoplasia of the uvula (HP:0010293)1.71551815
149Atrophy/Degeneration involving motor neurons (HP:0007373)1.71355576
150Hypoplasia of the radius (HP:0002984)1.70989436
151Pelvic girdle muscle weakness (HP:0003749)1.70553325
152Hyperparathyroidism (HP:0000843)1.69639709
153Slender long bone (HP:0003100)1.67381060
154Natal tooth (HP:0000695)1.66916051
155Fragile skin (HP:0001030)1.66155292
156Hypercalcemia (HP:0003072)1.65798309
157Ankyloglossia (HP:0010296)1.65443151
158Orthostatic hypotension (HP:0001278)1.63493703
159Fatigue (HP:0012378)1.62219580
160Atresia of the external auditory canal (HP:0000413)1.61288501
161Hypokinesia (HP:0002375)1.60972599
162Elfin facies (HP:0004428)1.59368123
163Centrally nucleated skeletal muscle fibers (HP:0003687)1.58117683
164Termporal pattern (HP:0011008)1.57607618
165Insidious onset (HP:0003587)1.57607618
166Back pain (HP:0003418)1.57277396
167Sensory axonal neuropathy (HP:0003390)1.55804584
168Bowed forearm bones (HP:0003956)1.55074775
169Bowing of the arm (HP:0006488)1.55074775
170Nonimmune hydrops fetalis (HP:0001790)1.54540150
171Abnormality of reticulocytes (HP:0004312)1.53851011
172Hypergonadotropic hypogonadism (HP:0000815)1.53596626
173Spinal cord compression (HP:0002176)1.53408894
174Microglossia (HP:0000171)1.53075437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.88709677
2WEE13.70741150
3TRIB33.56765307
4IRAK33.54184457
5STK162.94943982
6NME22.84383817
7EIF2AK12.76903509
8TSSK62.64382555
9PIM22.61112234
10TESK22.53418207
11SMG12.51222382
12ICK2.50267582
13BRSK22.29735677
14NEK12.12585876
15CDC72.07603104
16PLK41.98700546
17EIF2AK31.98669682
18PASK1.85783032
19NEK21.83089054
20SRPK11.78147061
21RPS6KB21.77630650
22ACVR1B1.72416946
23EPHA21.70653957
24BCKDK1.69579071
25PLK11.63755998
26TTN1.57246786
27CDK71.48181566
28PRPF4B1.45387244
29TTK1.43609763
30VRK11.41637496
31MST41.40281168
32SIK11.36519185
33CDK121.36082670
34STK101.32953946
35PAK41.32949120
36FLT31.31835154
37DYRK31.31808422
38TESK11.30238753
39AURKB1.28590375
40LATS21.25626747
41BRSK11.22203678
42MAP4K11.21862315
43MAP3K111.17211663
44ERBB41.16499083
45ATR1.16039854
46CDK41.12822947
47PIM11.11160859
48MAPKAPK31.07720867
49PTK21.07466450
50EEF2K1.05108396
51MAP3K81.03989059
52KDR1.03964880
53PBK1.03516559
54PDGFRA1.01453847
55VRK21.00330186
56PLK30.99473029
57CHEK20.99091147
58AURKA0.98429753
59MST1R0.98382557
60TAOK20.98349810
61ZAK0.95717989
62MAP3K90.95074534
63CDK80.90155743
64PDK20.90108837
65CCNB10.88321699
66STK38L0.87207581
67STK40.86917934
68RPS6KA40.86239058
69TYK20.85668186
70MKNK10.85050696
71TEC0.83778667
72PKN20.83520043
73LIMK10.83353863
74MTOR0.82750177
75PIK3CG0.80011623
76CLK10.79763274
77CHEK10.79542996
78SIK30.79398549
79DMPK0.79355344
80MAP2K30.78482715
81TGFBR10.77089730
82IKBKB0.74763829
83PAK10.74179755
84ARAF0.74034381
85TLK10.72890822
86RIPK10.71274180
87LRRK20.71205453
88PTK60.70583126
89CSNK2A10.69763677
90KIT0.69364328
91MARK30.68505648
92IRAK20.65686116
93TXK0.63047014
94PRKCI0.62908230
95CSNK2A20.62219575
96ALK0.61032489
97CAMK1D0.60734928
98MOS0.60079529
99EIF2AK20.59808659
100BTK0.59627990
101PAK20.59576956
102KSR20.59384564
103MAP3K30.58724039
104ABL20.57168366
105BMX0.56945035
106BRAF0.56390905
107MAP3K140.53481194
108MET0.52964585
109MAPK110.52360205
110DYRK20.50787437
111MELK0.50278662
112CDK20.49831945
113GRK60.49806898
114MYLK0.49330842
115SCYL20.49025724
116MAP2K20.48614576
117TBK10.48224399
118MAP3K100.48120723
119CDK10.47245410
120CSF1R0.45943735
121JAK30.45682125
122DAPK30.45485506
123ZAP700.45263334
124RPS6KA50.44736707
125TAF10.44332955
126IRAK40.42361079
127MATK0.41649423
128CDK60.40678156
129RAF10.39461832
130MAP3K10.39237603
131ILK0.39215247
132ATM0.37581779
133AKT30.37569031
134FGFR40.37220105
135NTRK10.36005862
136CHUK0.35875725
137AKT20.35601983
138CAMK1G0.35167608
139MKNK20.34996818
140PRKG20.34978525
141CDK11A0.34695484

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.11025676
2Proteasome_Homo sapiens_hsa030503.97545499
3Mismatch repair_Homo sapiens_hsa034303.63453565
4RNA polymerase_Homo sapiens_hsa030203.40344747
5Ribosome_Homo sapiens_hsa030103.35522765
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.12306555
7Spliceosome_Homo sapiens_hsa030402.70454296
8Base excision repair_Homo sapiens_hsa034102.57717750
9Homologous recombination_Homo sapiens_hsa034402.44931564
10RNA transport_Homo sapiens_hsa030132.42244512
11Pyrimidine metabolism_Homo sapiens_hsa002402.39160790
12Nucleotide excision repair_Homo sapiens_hsa034202.38520941
13One carbon pool by folate_Homo sapiens_hsa006702.32821187
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14206787
15Cell cycle_Homo sapiens_hsa041101.83633832
16Bladder cancer_Homo sapiens_hsa052191.67130081
17Sulfur relay system_Homo sapiens_hsa041221.60248793
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59426991
19Folate biosynthesis_Homo sapiens_hsa007901.57916677
20Vitamin B6 metabolism_Homo sapiens_hsa007501.49900380
21Fanconi anemia pathway_Homo sapiens_hsa034601.44971418
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44295843
23Non-homologous end-joining_Homo sapiens_hsa034501.42556535
24RNA degradation_Homo sapiens_hsa030181.41584227
25p53 signaling pathway_Homo sapiens_hsa041151.36031235
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35645530
27Basal transcription factors_Homo sapiens_hsa030221.34502883
28Chronic myeloid leukemia_Homo sapiens_hsa052201.33133333
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32023017
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.25381491
31Biosynthesis of amino acids_Homo sapiens_hsa012301.24079678
32Pentose phosphate pathway_Homo sapiens_hsa000301.20922040
33Purine metabolism_Homo sapiens_hsa002301.20439935
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.20425022
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.20043605
36Pancreatic cancer_Homo sapiens_hsa052121.19604546
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06805094
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05585974
39Epstein-Barr virus infection_Homo sapiens_hsa051691.04925779
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02511986
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99019605
42Non-small cell lung cancer_Homo sapiens_hsa052230.98361611
43MicroRNAs in cancer_Homo sapiens_hsa052060.97557746
44Protein export_Homo sapiens_hsa030600.96380672
45Carbon metabolism_Homo sapiens_hsa012000.95316295
46Antigen processing and presentation_Homo sapiens_hsa046120.93868797
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93433654
48Fructose and mannose metabolism_Homo sapiens_hsa000510.93106207
49Glutathione metabolism_Homo sapiens_hsa004800.92243269
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.90234533
51Parkinsons disease_Homo sapiens_hsa050120.90229914
52mRNA surveillance pathway_Homo sapiens_hsa030150.89501718
53Alcoholism_Homo sapiens_hsa050340.88859893
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88791536
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88583604
56N-Glycan biosynthesis_Homo sapiens_hsa005100.86218060
57Selenocompound metabolism_Homo sapiens_hsa004500.84597056
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83233673
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77489481
60Oxidative phosphorylation_Homo sapiens_hsa001900.75040231
61Proteoglycans in cancer_Homo sapiens_hsa052050.74845446
62Legionellosis_Homo sapiens_hsa051340.73090474
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72357240
64Huntingtons disease_Homo sapiens_hsa050160.72319877
65Acute myeloid leukemia_Homo sapiens_hsa052210.72183740
66Hippo signaling pathway_Homo sapiens_hsa043900.70970047
67Prion diseases_Homo sapiens_hsa050200.70754635
68Herpes simplex infection_Homo sapiens_hsa051680.70009848
69Renal cell carcinoma_Homo sapiens_hsa052110.69618175
70VEGF signaling pathway_Homo sapiens_hsa043700.68974586
71Primary immunodeficiency_Homo sapiens_hsa053400.68104594
72Endometrial cancer_Homo sapiens_hsa052130.67222128
73Vibrio cholerae infection_Homo sapiens_hsa051100.66611786
74Colorectal cancer_Homo sapiens_hsa052100.65918380
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64959478
76Arginine and proline metabolism_Homo sapiens_hsa003300.64694426
77Glioma_Homo sapiens_hsa052140.64537042
78Adherens junction_Homo sapiens_hsa045200.64061881
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62867833
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62399755
81Prostate cancer_Homo sapiens_hsa052150.62341615
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61328038
83Melanoma_Homo sapiens_hsa052180.60522419
84Galactose metabolism_Homo sapiens_hsa000520.58670016
85Insulin signaling pathway_Homo sapiens_hsa049100.56627211
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56575568
87Viral carcinogenesis_Homo sapiens_hsa052030.55409854
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55280156
89Metabolic pathways_Homo sapiens_hsa011000.54224831
90Systemic lupus erythematosus_Homo sapiens_hsa053220.53567764
91Hepatitis B_Homo sapiens_hsa051610.52576584
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52130230
93Focal adhesion_Homo sapiens_hsa045100.50697544
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49525531
95Phenylalanine metabolism_Homo sapiens_hsa003600.49264749
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49039639
97Oocyte meiosis_Homo sapiens_hsa041140.47150828
98Sulfur metabolism_Homo sapiens_hsa009200.46680842
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46461742
100mTOR signaling pathway_Homo sapiens_hsa041500.46448431
101Thyroid cancer_Homo sapiens_hsa052160.46383802
102Tyrosine metabolism_Homo sapiens_hsa003500.45550432
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.45475515
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.44800143
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44797976
106Regulation of autophagy_Homo sapiens_hsa041400.44646380
107Apoptosis_Homo sapiens_hsa042100.43596905
108Peroxisome_Homo sapiens_hsa041460.43064993
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42433918
110Chemical carcinogenesis_Homo sapiens_hsa052040.41989141
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41242381
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41108039
113Basal cell carcinoma_Homo sapiens_hsa052170.40785157
114Fatty acid elongation_Homo sapiens_hsa000620.40752921
115Measles_Homo sapiens_hsa051620.40612976
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40309055
117Allograft rejection_Homo sapiens_hsa053300.40200267
118Steroid biosynthesis_Homo sapiens_hsa001000.39998497
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39973808
120Other glycan degradation_Homo sapiens_hsa005110.39582531
121Notch signaling pathway_Homo sapiens_hsa043300.39272835
122beta-Alanine metabolism_Homo sapiens_hsa004100.38698551
123Arachidonic acid metabolism_Homo sapiens_hsa005900.37741679
124Vitamin digestion and absorption_Homo sapiens_hsa049770.36985703
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35944982
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.35630193
127HTLV-I infection_Homo sapiens_hsa051660.35356373
128Shigellosis_Homo sapiens_hsa051310.35199298
129Pyruvate metabolism_Homo sapiens_hsa006200.34353948
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34103076
131Histidine metabolism_Homo sapiens_hsa003400.33975120
132Fatty acid degradation_Homo sapiens_hsa000710.31088279
133Retinol metabolism_Homo sapiens_hsa008300.30184174
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29205481
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21955825
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21136423
137Graft-versus-host disease_Homo sapiens_hsa053320.20008939
138Small cell lung cancer_Homo sapiens_hsa052220.19982331
139Propanoate metabolism_Homo sapiens_hsa006400.19579640
140Linoleic acid metabolism_Homo sapiens_hsa005910.19182586
141Alzheimers disease_Homo sapiens_hsa050100.18680872
142Renin-angiotensin system_Homo sapiens_hsa046140.17933245

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