RRM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.82558074
2DNA unwinding involved in DNA replication (GO:0006268)5.54244372
3DNA replication initiation (GO:0006270)5.53879860
4DNA strand elongation (GO:0022616)5.52930201
5telomere maintenance via semi-conservative replication (GO:0032201)5.36853695
6DNA replication checkpoint (GO:0000076)5.33318666
7protein localization to kinetochore (GO:0034501)5.23343155
8telomere maintenance via recombination (GO:0000722)4.88749360
9mitotic recombination (GO:0006312)4.77866063
10mitotic metaphase plate congression (GO:0007080)4.71116257
11mitotic sister chromatid cohesion (GO:0007064)4.70742739
12establishment of integrated proviral latency (GO:0075713)4.63307589
13DNA replication-dependent nucleosome organization (GO:0034723)4.58080152
14DNA replication-dependent nucleosome assembly (GO:0006335)4.58080152
15nucleobase biosynthetic process (GO:0046112)4.52604264
16protein localization to chromosome, centromeric region (GO:0071459)4.50425865
17* regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.41695603
18CENP-A containing nucleosome assembly (GO:0034080)4.33585476
19kinetochore organization (GO:0051383)4.32248486
20mitotic chromosome condensation (GO:0007076)4.29766914
21purine nucleobase biosynthetic process (GO:0009113)4.29686387
22mitotic nuclear envelope disassembly (GO:0007077)4.24659486
23chromatin remodeling at centromere (GO:0031055)4.24532543
24mitotic sister chromatid segregation (GO:0000070)4.24151725
25telomere maintenance via telomere lengthening (GO:0010833)4.23800984
26DNA topological change (GO:0006265)4.20100172
27nucleotide-excision repair, DNA gap filling (GO:0006297)4.08780618
28DNA ligation (GO:0006266)4.05189054
29DNA replication-independent nucleosome organization (GO:0034724)4.04242478
30DNA replication-independent nucleosome assembly (GO:0006336)4.04242478
31metaphase plate congression (GO:0051310)4.01962024
32IMP biosynthetic process (GO:0006188)3.99698582
33nuclear pore organization (GO:0006999)3.98418578
34sister chromatid segregation (GO:0000819)3.95432603
35nuclear envelope disassembly (GO:0051081)3.93305595
36membrane disassembly (GO:0030397)3.93305595
37attachment of spindle microtubules to kinetochore (GO:0008608)3.92380422
38regulation of spindle organization (GO:0090224)3.86534779
39formation of translation preinitiation complex (GO:0001731)3.82668158
40regulation of sister chromatid cohesion (GO:0007063)3.82119298
41kinetochore assembly (GO:0051382)3.80946285
42DNA packaging (GO:0006323)3.80282552
43establishment of chromosome localization (GO:0051303)3.78045657
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.76571895
45nuclear pore complex assembly (GO:0051292)3.76271832
46folic acid-containing compound biosynthetic process (GO:0009396)3.68002691
47histone exchange (GO:0043486)3.63426618
48positive regulation of chromosome segregation (GO:0051984)3.63208379
49regulation of DNA endoreduplication (GO:0032875)3.62897861
50establishment of viral latency (GO:0019043)3.58597676
51regulation of double-strand break repair via homologous recombination (GO:0010569)3.54151981
52regulation of centrosome cycle (GO:0046605)3.42006528
53DNA duplex unwinding (GO:0032508)3.41778451
54double-strand break repair via nonhomologous end joining (GO:0006303)3.41447490
55non-recombinational repair (GO:0000726)3.41447490
56ribosome assembly (GO:0042255)3.41171421
57DNA geometric change (GO:0032392)3.40357795
58IMP metabolic process (GO:0046040)3.39906703
59regulation of chromosome segregation (GO:0051983)3.36231882
60microtubule depolymerization (GO:0007019)3.34235883
61spindle checkpoint (GO:0031577)3.33531254
62* G1/S transition of mitotic cell cycle (GO:0000082)3.30179277
63* cell cycle G1/S phase transition (GO:0044843)3.30179277
64deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.29367690
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.27422825
66negative regulation of chromosome segregation (GO:0051985)3.27251747
67maturation of SSU-rRNA (GO:0030490)3.26781190
68telomere organization (GO:0032200)3.26487820
69telomere maintenance (GO:0000723)3.26210263
70chromosome segregation (GO:0007059)3.25332679
71negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.25018016
72negative regulation of sister chromatid segregation (GO:0033046)3.25018016
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.25018016
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.25018016
75protein localization to chromosome (GO:0034502)3.24227305
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.23835805
77chromatin assembly or disassembly (GO:0006333)3.22453784
78regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.22295972
79ribosome biogenesis (GO:0042254)3.21798707
80histone-serine phosphorylation (GO:0035404)3.20801669
81meiotic chromosome segregation (GO:0045132)3.20285668
82postreplication repair (GO:0006301)3.19951347
83regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.19562313
84protein K6-linked ubiquitination (GO:0085020)3.18721313
85translesion synthesis (GO:0019985)3.17476902
86spindle assembly checkpoint (GO:0071173)3.16664677
87* mitotic cell cycle (GO:0000278)3.16484689
88somatic hypermutation of immunoglobulin genes (GO:0016446)3.15431526
89somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15431526
90negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14916318
91regulation of mitotic spindle organization (GO:0060236)3.14389286
92heterochromatin organization (GO:0070828)3.13511196
93spliceosomal snRNP assembly (GO:0000387)3.11542532
94mitotic spindle assembly checkpoint (GO:0007094)3.11513518
95transcription-coupled nucleotide-excision repair (GO:0006283)3.11285527
96DNA synthesis involved in DNA repair (GO:0000731)3.11240621
97protein complex localization (GO:0031503)3.10582949
98mitotic spindle checkpoint (GO:0071174)3.07694883
99nuclear envelope organization (GO:0006998)3.07502323
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06548338
101mismatch repair (GO:0006298)3.05295258
102ATP-dependent chromatin remodeling (GO:0043044)3.04965264
103DNA conformation change (GO:0071103)3.04761517
104chromosome condensation (GO:0030261)3.03693480
105pore complex assembly (GO:0046931)3.01581422
106regulation of mitotic sister chromatid separation (GO:0010965)3.01485506
107regulation of mitotic sister chromatid segregation (GO:0033047)3.01485506
108regulation of sister chromatid segregation (GO:0033045)3.01485506
109negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00990950
110base-excision repair (GO:0006284)2.97913870
111regulation of centriole replication (GO:0046599)2.96696322
112positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95515211
113positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.95215755
114positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.95215755
115positive regulation of mitotic sister chromatid separation (GO:1901970)2.95215755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human4.98826290
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.19569398
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.96080693
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71504803
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.53146445
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06193836
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84525222
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71933939
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.68902768
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66317543
11AR_21909140_ChIP-Seq_LNCAP_Human2.63247402
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59354245
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.46502940
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.45141475
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44162250
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37216533
17* E2F1_21310950_ChIP-Seq_MCF-7_Human2.23447611
18XRN2_22483619_ChIP-Seq_HELA_Human2.22967126
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20206096
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14294475
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06685631
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.01484220
23E2F7_22180533_ChIP-Seq_HELA_Human10.7634776
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99225443
25VDR_23849224_ChIP-Seq_CD4+_Human1.94288439
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92088613
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91677679
28DCP1A_22483619_ChIP-Seq_HELA_Human1.87299162
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83611294
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83600917
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78625245
32FOXP3_21729870_ChIP-Seq_TREG_Human1.78611662
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74069647
34GABP_19822575_ChIP-Seq_HepG2_Human1.69811877
35* TTF2_22483619_ChIP-Seq_HELA_Human1.67703387
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65039523
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64696855
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63332869
39ELK1_19687146_ChIP-ChIP_HELA_Human1.58126713
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51971116
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49050719
42MYC_22102868_ChIP-Seq_BL_Human1.47982478
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46348265
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46292830
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44571450
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42083961
47CIITA_25753668_ChIP-Seq_RAJI_Human1.40358156
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38850286
49* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35232544
50KDM5A_27292631_Chip-Seq_BREAST_Human1.34233848
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33539472
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32942122
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32618810
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32077801
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.29769755
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25197481
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23481033
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23467321
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21624226
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21370284
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.19400489
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17699875
63* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17402859
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17297815
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.15777831
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12943241
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11789828
68* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10464093
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10386478
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10003474
71TFEB_21752829_ChIP-Seq_HELA_Human1.08937922
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08444558
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07316316
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03535930
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02779091
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02723073
77* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00914654
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97058564
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94698330
80ZNF263_19887448_ChIP-Seq_K562_Human0.94486775
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92879441
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92198505
83* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91788707
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89527575
85NANOG_21062744_ChIP-ChIP_HESCs_Human0.89122231
86VDR_21846776_ChIP-Seq_THP-1_Human0.87655444
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87153604
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86914271
89* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86315890
90TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85738530
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85253623
92MYC_18940864_ChIP-ChIP_HL60_Human0.85253282
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.83267054
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82887816
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82683503
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81304638
97SALL1_21062744_ChIP-ChIP_HESCs_Human0.80644193
98CHD1_26751641_Chip-Seq_LNCaP_Human0.80158975
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80006012
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78679527
101* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78303238
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76247788
103* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74217008
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.73821205
105* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73700065
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71987849
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71849250
108SPI1_23547873_ChIP-Seq_NB4_Human0.71726211
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71596686
110* SOX17_20123909_ChIP-Seq_XEN_Mouse0.71563030
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.71258226
112NANOG_16153702_ChIP-ChIP_HESCs_Human0.71173429
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69934016
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.64812701
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.64436169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.48471168
2MP0010094_abnormal_chromosome_stability5.24900355
3MP0003111_abnormal_nucleus_morphology4.93693884
4MP0004957_abnormal_blastocyst_morpholog4.40977519
5MP0003077_abnormal_cell_cycle4.25453674
6MP0008057_abnormal_DNA_replication4.07067538
7MP0008058_abnormal_DNA_repair3.17793530
8MP0008007_abnormal_cellular_replicative2.96369029
9MP0008932_abnormal_embryonic_tissue2.91098520
10MP0001730_embryonic_growth_arrest2.54285861
11MP0000350_abnormal_cell_proliferation2.41702061
12MP0010352_gastrointestinal_tract_polyps2.35796460
13MP0003123_paternal_imprinting2.26097413
14MP0009697_abnormal_copulation2.23144250
15MP0010307_abnormal_tumor_latency2.03141976
16MP0002396_abnormal_hematopoietic_system1.97883103
17MP0001672_abnormal_embryogenesis/_devel1.88986296
18MP0005380_embryogenesis_phenotype1.88986296
19MP0010030_abnormal_orbit_morphology1.84223015
20MP0001697_abnormal_embryo_size1.83352460
21MP0003786_premature_aging1.81452678
22MP0008877_abnormal_DNA_methylation1.74895895
23MP0003984_embryonic_growth_retardation1.69944431
24MP0002080_prenatal_lethality1.67861296
25MP0002088_abnormal_embryonic_growth/wei1.65650423
26MP0000490_abnormal_crypts_of1.61762635
27MP0002085_abnormal_embryonic_tissue1.61279113
28MP0005076_abnormal_cell_differentiation1.53860761
29MP0003718_maternal_effect1.52373966
30MP0003806_abnormal_nucleotide_metabolis1.51759416
31MP0002084_abnormal_developmental_patter1.44849635
32MP0000313_abnormal_cell_death1.43148338
33MP0004197_abnormal_fetal_growth/weight/1.43007615
34MP0002086_abnormal_extraembryonic_tissu1.42928143
35MP0002019_abnormal_tumor_incidence1.42432895
36MP0004808_abnormal_hematopoietic_stem1.41523511
37MP0009053_abnormal_anal_canal1.40998792
38MP0003567_abnormal_fetal_cardiomyocyte1.37150996
39MP0003705_abnormal_hypodermis_morpholog1.29319446
40MP0003121_genomic_imprinting1.23844617
41MP0009333_abnormal_splenocyte_physiolog1.23105462
42MP0003315_abnormal_perineum_morphology1.22570111
43MP0010234_abnormal_vibrissa_follicle1.22458525
44MP0006054_spinal_hemorrhage1.21768904
45MP0001346_abnormal_lacrimal_gland1.18069756
46MP0004185_abnormal_adipocyte_glucose1.18032743
47MP0006035_abnormal_mitochondrial_morpho1.14519955
48MP0003890_abnormal_embryonic-extraembry1.11385744
49MP0001293_anophthalmia1.05239528
50MP0001545_abnormal_hematopoietic_system1.04688104
51MP0005397_hematopoietic_system_phenotyp1.04688104
52MP0005451_abnormal_body_composition1.04579067
53MP0005023_abnormal_wound_healing1.04284163
54MP0002210_abnormal_sex_determination1.03119905
55MP0000537_abnormal_urethra_morphology1.02467946
56MP0004233_abnormal_muscle_weight1.02081007
57MP0002160_abnormal_reproductive_system1.01077427
58MP0000703_abnormal_thymus_morphology0.99179525
59MP0002009_preneoplasia0.98183656
60MP0002697_abnormal_eye_size0.95949681
61MP0003566_abnormal_cell_adhesion0.94292803
62MP0000858_altered_metastatic_potential0.93040408
63MP0001145_abnormal_male_reproductive0.92065979
64MP0005623_abnormal_meninges_morphology0.91837395
65MP0002111_abnormal_tail_morphology0.90638693
66MP0009672_abnormal_birth_weight0.90117642
67MP0003950_abnormal_plasma_membrane0.88729039
68MP0000358_abnormal_cell_content/0.88314079
69MP0005384_cellular_phenotype0.87437262
70MP0003119_abnormal_digestive_system0.86759004
71MP0002722_abnormal_immune_system0.86377831
72MP0003186_abnormal_redox_activity0.86273610
73MP0003937_abnormal_limbs/digits/tail_de0.86219109
74MP0005621_abnormal_cell_physiology0.85895173
75MP0003941_abnormal_skin_development0.85043194
76MP0002796_impaired_skin_barrier0.84162783
77MP0002398_abnormal_bone_marrow0.82922226
78MP0005389_reproductive_system_phenotype0.82412801
79MP0003221_abnormal_cardiomyocyte_apopto0.79723562
80MP0000428_abnormal_craniofacial_morphol0.78615547
81MP0000689_abnormal_spleen_morphology0.78270303
82MP0005408_hypopigmentation0.76827706
83MP0001119_abnormal_female_reproductive0.76684557
84MP0001915_intracranial_hemorrhage0.76416759
85MP0002163_abnormal_gland_morphology0.75892107
86MP0000653_abnormal_sex_gland0.75690412
87MP0001929_abnormal_gametogenesis0.72359195
88MP0002060_abnormal_skin_morphology0.71102400
89MP0003699_abnormal_female_reproductive0.70592627
90MP0003943_abnormal_hepatobiliary_system0.70272555
91MP0001881_abnormal_mammary_gland0.69812595
92MP0002653_abnormal_ependyma_morphology0.69163932
93MP0001661_extended_life_span0.68120948
94MP0006292_abnormal_olfactory_placode0.67906100
95MP0003763_abnormal_thymus_physiology0.67484735
96MP0002429_abnormal_blood_cell0.66153124
97MP0003656_abnormal_erythrocyte_physiolo0.65760350
98MP0009703_decreased_birth_body0.65497152
99MP0000750_abnormal_muscle_regeneration0.63572754
100MP0002092_abnormal_eye_morphology0.62931567
101MP0002006_tumorigenesis0.62391740
102MP0004133_heterotaxia0.61444195
103MP0006036_abnormal_mitochondrial_physio0.60806537
104MP0000733_abnormal_muscle_development0.60693937
105MP0001529_abnormal_vocalization0.60362265
106MP0002161_abnormal_fertility/fecundity0.60301262
107MP0003115_abnormal_respiratory_system0.60231330
108MP0001286_abnormal_eye_development0.59233671
109MP0002970_abnormal_white_adipose0.57998117
110MP0001216_abnormal_epidermal_layer0.56953920
111MP0002132_abnormal_respiratory_system0.56939822
112MP0000432_abnormal_head_morphology0.56910286
113MP0001919_abnormal_reproductive_system0.56518391
114MP0000049_abnormal_middle_ear0.55658730
115MP0001243_abnormal_dermal_layer0.54741136
116MP0004264_abnormal_extraembryonic_tissu0.54710227
117MP0000477_abnormal_intestine_morphology0.54448296
118MP0003448_altered_tumor_morphology0.53427227
119MP0003861_abnormal_nervous_system0.53094040
120MP0005501_abnormal_skin_physiology0.52928696
121MP0005171_absent_coat_pigmentation0.52924771
122MP0005395_other_phenotype0.52479616
123MP0001727_abnormal_embryo_implantation0.52441401
124MP0001849_ear_inflammation0.52046774
125MP0001542_abnormal_bone_strength0.50166896
126MP0004147_increased_porphyrin_level0.50159108
127MP0003755_abnormal_palate_morphology0.49964075
128MP0002877_abnormal_melanocyte_morpholog0.49691431
129MP0000627_abnormal_mammary_gland0.49528815
130MP0000762_abnormal_tongue_morphology0.48657733
131MP0001186_pigmentation_phenotype0.48291410

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.86523545
2Breast hypoplasia (HP:0003187)4.37537572
3Chromsome breakage (HP:0040012)4.10331119
4Patellar aplasia (HP:0006443)4.01000951
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.99061966
6Aplasia/Hypoplasia of the patella (HP:0006498)3.76623237
7Reticulocytopenia (HP:0001896)3.53675317
8Selective tooth agenesis (HP:0001592)3.45134380
9Degeneration of anterior horn cells (HP:0002398)3.37869212
10Abnormality of the anterior horn cell (HP:0006802)3.37869212
11Meckel diverticulum (HP:0002245)3.35902751
12Abnormality of chromosome stability (HP:0003220)3.35406220
13Carpal bone hypoplasia (HP:0001498)3.32356437
14Abnormality of the ileum (HP:0001549)3.19697393
15Oral leukoplakia (HP:0002745)3.14858955
16Absent radius (HP:0003974)3.13286445
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.10046408
18Rough bone trabeculation (HP:0100670)3.06435672
19Abnormality of the preputium (HP:0100587)3.03062754
20Hypoplasia of the capital femoral epiphysis (HP:0003090)3.01932135
21Colon cancer (HP:0003003)2.99542350
22Embryonal renal neoplasm (HP:0011794)2.98301369
23Absent forearm bone (HP:0003953)2.92668984
24Aplasia involving forearm bones (HP:0009822)2.92668984
25Duodenal stenosis (HP:0100867)2.89474551
26Small intestinal stenosis (HP:0012848)2.89474551
27Medulloblastoma (HP:0002885)2.83771922
28Poikiloderma (HP:0001029)2.81988339
29Microvesicular hepatic steatosis (HP:0001414)2.81023399
30Ependymoma (HP:0002888)2.80573949
31Impulsivity (HP:0100710)2.78679503
32Ectopic kidney (HP:0000086)2.76160749
33Cortical dysplasia (HP:0002539)2.66919747
34Abnormality of cells of the erythroid lineage (HP:0012130)2.65309788
35Absent thumb (HP:0009777)2.62265989
36Abnormal number of erythroid precursors (HP:0012131)2.61595210
37Abnormality of the labia minora (HP:0012880)2.55418821
38Premature graying of hair (HP:0002216)2.51171491
39Neoplasm of the pancreas (HP:0002894)2.47626626
40Bone marrow hypocellularity (HP:0005528)2.45983587
41Aplastic anemia (HP:0001915)2.44934983
42Abnormal number of incisors (HP:0011064)2.44916954
43Agnosia (HP:0010524)2.42537906
44Abnormality of the duodenum (HP:0002246)2.42100886
45Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.41574216
46Myelodysplasia (HP:0002863)2.41007717
47Abnormality of glycolysis (HP:0004366)2.40885847
48Abnormal lung lobation (HP:0002101)2.33740404
49Slender long bone (HP:0003100)2.33624401
50Trismus (HP:0000211)2.32786159
51Atresia of the external auditory canal (HP:0000413)2.31855320
52Microretrognathia (HP:0000308)2.29366529
53Abnormal gallbladder physiology (HP:0012438)2.29226076
54Cholecystitis (HP:0001082)2.29226076
55Rhabdomyosarcoma (HP:0002859)2.26438030
56Duplicated collecting system (HP:0000081)2.26367263
57Overlapping toe (HP:0001845)2.26347215
58Horseshoe kidney (HP:0000085)2.25885592
59Proximal placement of thumb (HP:0009623)2.24597905
6011 pairs of ribs (HP:0000878)2.24118080
61Triphalangeal thumb (HP:0001199)2.23976376
62Absent epiphyses (HP:0010577)2.23343044
63Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.23343044
64Tracheoesophageal fistula (HP:0002575)2.23341611
65Sloping forehead (HP:0000340)2.23290890
66Deviation of the thumb (HP:0009603)2.23200665
67Volvulus (HP:0002580)2.22287260
68Increased nuchal translucency (HP:0010880)2.17642476
69Small epiphyses (HP:0010585)2.17484090
70Abnormal trabecular bone morphology (HP:0100671)2.17423317
71Multiple enchondromatosis (HP:0005701)2.15880227
72Progressive muscle weakness (HP:0003323)2.13404875
73High pitched voice (HP:0001620)2.11163266
74Cerebral hypomyelination (HP:0006808)2.10400099
75Macrocytic anemia (HP:0001972)2.10310229
76Abnormal umbilical cord blood vessels (HP:0011403)2.07624965
77Single umbilical artery (HP:0001195)2.07624965
78Abnormality of the fetal cardiovascular system (HP:0010948)2.07624965
79Choanal atresia (HP:0000453)2.07166336
80Abnormality of pyrimidine metabolism (HP:0004353)2.06918837
81Arteriovenous malformation (HP:0100026)2.06275869
82Short thumb (HP:0009778)2.05212599
83Supernumerary spleens (HP:0009799)2.04483654
84Abnormality of the carotid arteries (HP:0005344)2.04462688
85Increased serum pyruvate (HP:0003542)2.04456715
86Ureteral duplication (HP:0000073)2.04337058
87Abnormality of cochlea (HP:0000375)2.03487877
88Short 4th metacarpal (HP:0010044)2.03269118
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03269118
90Cellular immunodeficiency (HP:0005374)2.02934247
91Cafe-au-lait spot (HP:0000957)2.02666494
92Progressive external ophthalmoplegia (HP:0000590)2.02654260
93Abnormality of chromosome segregation (HP:0002916)2.01618928
94Microglossia (HP:0000171)1.99551870
95Abnormality of DNA repair (HP:0003254)1.98704956
96Abnormality of the calcaneus (HP:0008364)1.97641136
97Short middle phalanx of the 5th finger (HP:0004220)1.97619808
98Aplasia/Hypoplasia of the sternum (HP:0006714)1.96068738
99Facial hemangioma (HP:0000329)1.95486180
100Atrophy/Degeneration involving motor neurons (HP:0007373)1.94816270
101Embryonal neoplasm (HP:0002898)1.94416626
102Neoplasm of the colon (HP:0100273)1.91009517
103Breast aplasia (HP:0100783)1.89502013
104Deep philtrum (HP:0002002)1.89483724
105Pallor (HP:0000980)1.89440555
106Abdominal situs inversus (HP:0003363)1.88637191
107Abnormality of abdominal situs (HP:0011620)1.88637191
108Basal cell carcinoma (HP:0002671)1.88436093
109Cleft eyelid (HP:0000625)1.87104327
110Duplication of thumb phalanx (HP:0009942)1.86725775
111Abnormality of the renal collecting system (HP:0004742)1.86616373
112Facial cleft (HP:0002006)1.86156402
113Aplasia/hypoplasia of the humerus (HP:0006507)1.85859722
114Entropion (HP:0000621)1.84652872
115Missing ribs (HP:0000921)1.83586650
116Secondary amenorrhea (HP:0000869)1.82768234
117Aplasia/Hypoplasia of the breasts (HP:0010311)1.82486892
118Abnormality of the umbilical cord (HP:0010881)1.82243014
119Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81998063
120Megaloblastic anemia (HP:0001889)1.81644896
121Insomnia (HP:0100785)1.80542549
122Abnormality of reticulocytes (HP:0004312)1.79614730
123Squamous cell carcinoma (HP:0002860)1.79384259
124Nephroblastoma (Wilms tumor) (HP:0002667)1.77001018
125Lymphoma (HP:0002665)1.76379723
126Irregular epiphyses (HP:0010582)1.76252916
127Glossoptosis (HP:0000162)1.75248835
128Glioma (HP:0009733)1.75237831
129Abnormality of the heme biosynthetic pathway (HP:0010472)1.73959309
130Pancytopenia (HP:0001876)1.72889055
131Prominent nose (HP:0000448)1.72187349
132Clubbing of toes (HP:0100760)1.71105743
133Astrocytoma (HP:0009592)1.69652895
134Abnormality of the astrocytes (HP:0100707)1.69652895
135Orthostatic hypotension (HP:0001278)1.64891799
136Abnormal foot bone ossification (HP:0010675)1.64708669
137Abnormalities of placenta or umbilical cord (HP:0001194)1.59772939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.88504323
2WEE14.78866718
3BUB14.69310468
4EIF2AK13.57197110
5NEK22.83139071
6NEK12.78748694
7TESK22.46140902
8BRSK22.37793610
9VRK22.36588603
10PLK42.35346809
11TTK2.29149729
12SRPK12.26076078
13EIF2AK32.16264681
14SMG12.12996417
15PLK12.12267450
16CCNB11.98147167
17ACVR1B1.97111725
18TSSK61.90599777
19TRIM281.89453464
20BRSK11.88293829
21MKNK11.81588742
22AURKB1.74280509
23PLK31.72852748
24TAF11.68589113
25NME21.66542776
26TESK11.66062344
27CDK71.64151204
28ATR1.60310595
29VRK11.57958691
30MST41.57412323
31MAP3K81.55219557
32STK101.53222230
33RPS6KA41.53070222
34PASK1.48740470
35CHEK21.40709515
36AURKA1.36338195
37TLK11.34797793
38RPS6KB21.25573267
39CDK41.21539107
40DYRK31.19457923
41STK41.19363883
42CHEK11.17368187
43STK161.17104800
44SIK31.12772274
45CDK121.12395478
46SCYL21.12031208
47LIMK11.10609232
48ZAK1.06428737
49MST1R1.03592523
50MKNK21.03551807
51PAK40.98596656
52EPHA20.95363382
53EEF2K0.93749997
54MAP3K100.91422088
55EIF2AK20.88820344
56PIM20.88384890
57BCR0.86480852
58TGFBR10.82786827
59PIM10.81344525
60* CDK20.78537895
61ATM0.78333537
62CDK60.74372047
63MELK0.74041217
64PAK10.71846944
65TAOK20.71381950
66IRAK30.71080290
67LRRK20.70139697
68NME10.68411750
69PBK0.66141436
70ICK0.65223584
71MET0.64891212
72KDR0.64205518
73MAP3K110.63320046
74CDK90.63187661
75ERBB40.62925946
76* CDK10.62303154
77BRAF0.61603481
78LATS20.60372977
79CLK10.60102320
80CSNK2A10.59943794
81STK38L0.57034548
82STK30.56995103
83ALK0.53050296
84CDK80.51104016
85NEK90.50560749
86CSNK2A20.49939285
87MAP2K30.49340221
88ERBB30.48194585
89PRKCI0.43758514
90MAPKAPK30.41973772
91RPS6KA50.41343197
92* CDK180.37908375
93DAPK10.35964529
94BRD40.35756914
95KSR10.35423928
96PRPF4B0.35001105
97PKN20.33544925
98AKT20.33119115
99* CDK150.30457322
100* CDK11A0.30374468
101MAP4K10.29611494
102* CDK140.29163445
103TRIB30.29097634
104DYRK20.28189608
105PRKDC0.26781553
106PAK20.26505436
107MAPK110.25982626
108MTOR0.25244630
109PNCK0.24057309
110ARAF0.23369343
111FGFR10.23035262
112YES10.22960131
113CDK30.22804352
114MAP3K50.22054536
115MAP3K30.21460672
116TRPM70.21388111
117LATS10.21005539
118GRK60.20624521
119MAPKAPK20.19688400
120PTK20.19194658
121CSNK1E0.18790539
122NUAK10.18555869
123ILK0.17995724
124MAPK140.17865749
125AKT10.16445894
126AKT30.14703169
127TTN0.13650816

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.84544843
2Mismatch repair_Homo sapiens_hsa034304.67167813
3Homologous recombination_Homo sapiens_hsa034403.38948785
4Base excision repair_Homo sapiens_hsa034103.31312037
5Cell cycle_Homo sapiens_hsa041103.27565327
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.21464634
7Spliceosome_Homo sapiens_hsa030403.17902506
8Proteasome_Homo sapiens_hsa030503.12512631
9RNA transport_Homo sapiens_hsa030133.05191541
10Nucleotide excision repair_Homo sapiens_hsa034202.98692216
11One carbon pool by folate_Homo sapiens_hsa006702.82363573
12RNA polymerase_Homo sapiens_hsa030202.76352661
13Ribosome_Homo sapiens_hsa030102.49565526
14* Pyrimidine metabolism_Homo sapiens_hsa002402.39424469
15Fanconi anemia pathway_Homo sapiens_hsa034602.36725746
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28868213
17Non-homologous end-joining_Homo sapiens_hsa034502.10671890
18* p53 signaling pathway_Homo sapiens_hsa041151.85624837
19RNA degradation_Homo sapiens_hsa030181.65734537
20Basal transcription factors_Homo sapiens_hsa030221.60168549
21mRNA surveillance pathway_Homo sapiens_hsa030151.59564967
22* Purine metabolism_Homo sapiens_hsa002301.21652376
23Systemic lupus erythematosus_Homo sapiens_hsa053221.21219897
24Epstein-Barr virus infection_Homo sapiens_hsa051691.21111905
25Oocyte meiosis_Homo sapiens_hsa041141.19865029
26Pyruvate metabolism_Homo sapiens_hsa006201.07216780
27Viral carcinogenesis_Homo sapiens_hsa052031.04706279
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00667264
29Biosynthesis of amino acids_Homo sapiens_hsa012300.95195506
30Vitamin B6 metabolism_Homo sapiens_hsa007500.94060656
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90885190
32Pentose phosphate pathway_Homo sapiens_hsa000300.89624718
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88795624
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87947789
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85168114
36HTLV-I infection_Homo sapiens_hsa051660.82243573
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.81735698
38Folate biosynthesis_Homo sapiens_hsa007900.81200902
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.81158363
40Antigen processing and presentation_Homo sapiens_hsa046120.77502939
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.77269170
42Herpes simplex infection_Homo sapiens_hsa051680.77153471
43MicroRNAs in cancer_Homo sapiens_hsa052060.76679615
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74858021
45Small cell lung cancer_Homo sapiens_hsa052220.73627658
46Fatty acid elongation_Homo sapiens_hsa000620.72582645
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72554160
48Selenocompound metabolism_Homo sapiens_hsa004500.71845678
49Steroid biosynthesis_Homo sapiens_hsa001000.64200113
50Carbon metabolism_Homo sapiens_hsa012000.56791238
51Lysine degradation_Homo sapiens_hsa003100.56633821
52Apoptosis_Homo sapiens_hsa042100.52517309
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52414335
54Legionellosis_Homo sapiens_hsa051340.51114470
55Hippo signaling pathway_Homo sapiens_hsa043900.51035421
56Bladder cancer_Homo sapiens_hsa052190.50362017
57Shigellosis_Homo sapiens_hsa051310.49919630
58Thyroid cancer_Homo sapiens_hsa052160.49674438
59* Glutathione metabolism_Homo sapiens_hsa004800.46806221
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44059605
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43622482
62TGF-beta signaling pathway_Homo sapiens_hsa043500.41354691
63Hepatitis B_Homo sapiens_hsa051610.40731214
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40060715
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39667514
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38184526
67Alcoholism_Homo sapiens_hsa050340.37127990
68Basal cell carcinoma_Homo sapiens_hsa052170.35687019
69Colorectal cancer_Homo sapiens_hsa052100.34808586
70Propanoate metabolism_Homo sapiens_hsa006400.34424495
71Chronic myeloid leukemia_Homo sapiens_hsa052200.34285728
72Parkinsons disease_Homo sapiens_hsa050120.34126039
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33900185
74Protein export_Homo sapiens_hsa030600.33174465
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32924910
76Viral myocarditis_Homo sapiens_hsa054160.32675625
77N-Glycan biosynthesis_Homo sapiens_hsa005100.32210936
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30328631
79Primary immunodeficiency_Homo sapiens_hsa053400.30279536
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29604060
81HIF-1 signaling pathway_Homo sapiens_hsa040660.29547481
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29483038
83Measles_Homo sapiens_hsa051620.28446946
84Sulfur relay system_Homo sapiens_hsa041220.28054446
85Fructose and mannose metabolism_Homo sapiens_hsa000510.27304174
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27093144
87Huntingtons disease_Homo sapiens_hsa050160.26821958
88Adherens junction_Homo sapiens_hsa045200.26502474
89Prostate cancer_Homo sapiens_hsa052150.24536757
90Pathways in cancer_Homo sapiens_hsa052000.22150491
91Hedgehog signaling pathway_Homo sapiens_hsa043400.19927592
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18669381
93Wnt signaling pathway_Homo sapiens_hsa043100.18412528
94Galactose metabolism_Homo sapiens_hsa000520.18254383
95Renin-angiotensin system_Homo sapiens_hsa046140.18198277
96Fatty acid metabolism_Homo sapiens_hsa012120.17596385
97Glioma_Homo sapiens_hsa052140.16996753
98Notch signaling pathway_Homo sapiens_hsa043300.16373770
99Arginine and proline metabolism_Homo sapiens_hsa003300.16272740
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.15646057
101Pancreatic cancer_Homo sapiens_hsa052120.15244790
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15220879
103* Metabolic pathways_Homo sapiens_hsa011000.13308152
104Proteoglycans in cancer_Homo sapiens_hsa052050.13171076
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12858923
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12770501
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.12751552
108Influenza A_Homo sapiens_hsa051640.11874490
109Non-small cell lung cancer_Homo sapiens_hsa052230.11462009
110Melanoma_Homo sapiens_hsa052180.10295454
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09948132
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.09796509
113FoxO signaling pathway_Homo sapiens_hsa040680.09227376
114Hematopoietic cell lineage_Homo sapiens_hsa046400.08993158
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.06054100
116Endometrial cancer_Homo sapiens_hsa052130.05455189

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