RRAS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.67822842
2protein complex localization (GO:0031503)4.13426116
3regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.01570078
4cellular protein complex localization (GO:0034629)3.84621762
5regulation of cardioblast differentiation (GO:0051890)3.58937566
6establishment of viral latency (GO:0019043)3.52760686
7anterior/posterior axis specification, embryo (GO:0008595)3.50197137
8nuclear pore organization (GO:0006999)3.45510233
9regulation of posttranscriptional gene silencing (GO:0060147)3.44814951
10regulation of gene silencing by miRNA (GO:0060964)3.44814951
11regulation of gene silencing by RNA (GO:0060966)3.44814951
12nuclear pore complex assembly (GO:0051292)3.42618639
13hippo signaling (GO:0035329)3.40402429
14metaphase plate congression (GO:0051310)3.39506197
15positive regulation of actin filament depolymerization (GO:0030836)3.34718581
16regulation of cell fate specification (GO:0042659)3.34000465
17nucleotide-sugar biosynthetic process (GO:0009226)3.32526698
18histone H2A monoubiquitination (GO:0035518)3.29446008
19pre-miRNA processing (GO:0031054)3.25925205
20folic acid-containing compound biosynthetic process (GO:0009396)3.23301055
21L-serine metabolic process (GO:0006563)3.22364504
22regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.22272432
23regulation of hippo signaling (GO:0035330)3.22134814
24positive regulation of chromosome segregation (GO:0051984)3.21595788
25polarized epithelial cell differentiation (GO:0030859)3.20820712
26CENP-A containing nucleosome assembly (GO:0034080)3.17163589
27chromatin remodeling at centromere (GO:0031055)3.16395323
28notochord development (GO:0030903)3.15599346
29mitotic chromosome condensation (GO:0007076)3.12937976
30regulation of transforming growth factor beta2 production (GO:0032909)3.10215024
31epithelial cell-cell adhesion (GO:0090136)3.09654954
32cell adhesion mediated by integrin (GO:0033627)3.08775339
33protein localization to endosome (GO:0036010)3.06878306
34mitotic nuclear envelope disassembly (GO:0007077)3.05843627
35positive regulation of SMAD protein import into nucleus (GO:0060391)3.04616883
36regulation of SMAD protein import into nucleus (GO:0060390)3.03718755
37heterochromatin organization (GO:0070828)3.01165599
38Rap protein signal transduction (GO:0032486)2.99756094
39negative regulation of fibroblast apoptotic process (GO:2000270)2.98175216
40nuclear envelope disassembly (GO:0051081)2.96295845
41membrane disassembly (GO:0030397)2.96295845
42regulation of spindle organization (GO:0090224)2.96129676
43IMP biosynthetic process (GO:0006188)2.95749375
44establishment of chromosome localization (GO:0051303)2.95083618
45endothelial cell morphogenesis (GO:0001886)2.94868795
46regulation of mitotic spindle organization (GO:0060236)2.90364900
47pore complex assembly (GO:0046931)2.90344759
48protein localization to kinetochore (GO:0034501)2.89076545
49IMP metabolic process (GO:0046040)2.88807608
50chondrocyte proliferation (GO:0035988)2.86939679
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86179622
52negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86179622
53negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86179622
54negative regulation of mitotic sister chromatid separation (GO:2000816)2.86179622
55negative regulation of sister chromatid segregation (GO:0033046)2.86179622
56DNA strand elongation involved in DNA replication (GO:0006271)2.83485048
57negative regulation of chromosome segregation (GO:0051985)2.82771522
58cell fate commitment involved in formation of primary germ layer (GO:0060795)2.81715004
59regulation of tight junction assembly (GO:2000810)2.79784469
60negative regulation of smooth muscle cell differentiation (GO:0051151)2.79713250
61regulation of chromosome segregation (GO:0051983)2.79652977
62mitotic metaphase plate congression (GO:0007080)2.79336497
63adherens junction assembly (GO:0034333)2.78722406
64DNA strand elongation (GO:0022616)2.77336067
65hemidesmosome assembly (GO:0031581)2.76880007
66telomere maintenance via telomerase (GO:0007004)2.76524752
67spindle checkpoint (GO:0031577)2.76154459
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.74251625
69regulation of mitotic metaphase/anaphase transition (GO:0030071)2.74251625
70mitotic sister chromatid cohesion (GO:0007064)2.72553442
71ribosome assembly (GO:0042255)2.71822515
72DNA unwinding involved in DNA replication (GO:0006268)2.71539459
73mitotic sister chromatid segregation (GO:0000070)2.71417597
74mitotic spindle checkpoint (GO:0071174)2.70958048
75protein localization to cell surface (GO:0034394)2.70380788
76histone exchange (GO:0043486)2.68371605
77nuclear envelope organization (GO:0006998)2.68203900
78formation of translation preinitiation complex (GO:0001731)2.67159026
79DNA replication-independent nucleosome assembly (GO:0006336)2.67145523
80DNA replication-independent nucleosome organization (GO:0034724)2.67145523
81negative regulation of DNA repair (GO:0045738)2.66100667
82RNA-dependent DNA replication (GO:0006278)2.65859770
83sarcomere organization (GO:0045214)2.64797432
84establishment of epithelial cell polarity (GO:0090162)2.64587566
85regulation of helicase activity (GO:0051095)2.64120940
86NLS-bearing protein import into nucleus (GO:0006607)2.63401206
87planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63234440
88cell-substrate junction assembly (GO:0007044)2.62246073
89ventricular cardiac muscle cell development (GO:0055015)2.62022733
90paraxial mesoderm development (GO:0048339)2.61327265
91regulation of mitotic sister chromatid separation (GO:0010965)2.60709167
92regulation of mitotic sister chromatid segregation (GO:0033047)2.60709167
93regulation of sister chromatid segregation (GO:0033045)2.60709167
94DNA replication checkpoint (GO:0000076)2.60395641
95skin morphogenesis (GO:0043589)2.59551454
96germ cell migration (GO:0008354)2.58908889
97regulation of translational termination (GO:0006449)2.58493172
98response to X-ray (GO:0010165)2.57849367
99glomerular visceral epithelial cell development (GO:0072015)2.57501329
100focal adhesion assembly (GO:0048041)2.56996676
101cell-substrate adherens junction assembly (GO:0007045)2.56996676
102sister chromatid segregation (GO:0000819)2.56124889
103actin filament depolymerization (GO:0030042)2.55635685
104negative regulation of chondrocyte differentiation (GO:0032331)2.55488908
105gap junction assembly (GO:0016264)2.54466157
106lens fiber cell development (GO:0070307)2.53380146
107regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.52610088
108DNA replication-dependent nucleosome assembly (GO:0006335)2.52100260
109DNA replication-dependent nucleosome organization (GO:0034723)2.52100260
110translational termination (GO:0006415)2.51961474
111mitotic spindle assembly checkpoint (GO:0007094)2.51710542
112wound healing, spreading of cells (GO:0044319)2.51535371
113positive regulation of catenin import into nucleus (GO:0035413)2.51273161
114ruffle organization (GO:0031529)2.51093021
115wound healing, spreading of epidermal cells (GO:0035313)2.50123472
116female gonad development (GO:0008585)2.49381881
117regulation of RNA export from nucleus (GO:0046831)2.49013076
118hepatocyte apoptotic process (GO:0097284)2.48083839
119regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.48051065
120protein heterotrimerization (GO:0070208)2.47990365
121regulation of translational fidelity (GO:0006450)2.47591465
122double-strand break repair via nonhomologous end joining (GO:0006303)2.45567555
123non-recombinational repair (GO:0000726)2.45567555
124spindle assembly checkpoint (GO:0071173)2.45554202
125positive regulation of endothelial cell apoptotic process (GO:2000353)2.45544695
126negative regulation of androgen receptor signaling pathway (GO:0060766)2.45540187
127regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.44057761
128viral transcription (GO:0019083)2.43840008
129spindle assembly involved in mitosis (GO:0090307)2.43751349
130translational initiation (GO:0006413)2.41650427
131regulation of histone H3-K9 methylation (GO:0051570)2.41327128
132positive regulation of protein autophosphorylation (GO:0031954)2.40716008
133cytoplasmic mRNA processing body assembly (GO:0033962)2.40431993
134Arp2/3 complex-mediated actin nucleation (GO:0034314)2.39752629
135endocardial cushion development (GO:0003197)2.39748195
136regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.38900202
137protein localization to chromosome, centromeric region (GO:0071459)2.38337366
138mesodermal cell differentiation (GO:0048333)2.37879259
139histone H2A ubiquitination (GO:0033522)2.35340309
140protein K6-linked ubiquitination (GO:0085020)2.35126609
141establishment of endothelial barrier (GO:0061028)2.34695387
142cell migration involved in sprouting angiogenesis (GO:0002042)2.33879195
143chromatin assembly (GO:0031497)2.33808371
144establishment of apical/basal cell polarity (GO:0035089)2.33557598
145endodermal cell differentiation (GO:0035987)2.31749343
146microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.31515848
147negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.30476201
148regulation of sister chromatid cohesion (GO:0007063)2.30105908
149regulation of early endosome to late endosome transport (GO:2000641)2.29535545
150semaphorin-plexin signaling pathway (GO:0071526)2.29312661
151maturation of SSU-rRNA (GO:0030490)2.28566743
152nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.26411686
153heterotypic cell-cell adhesion (GO:0034113)2.23977342
154regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.22506634
155platelet-derived growth factor receptor signaling pathway (GO:0048008)2.21822232
156plasma membrane repair (GO:0001778)2.21570001
157regulation of cell aging (GO:0090342)2.19943129
158collagen fibril organization (GO:0030199)2.18514337
159ribosomal small subunit biogenesis (GO:0042274)2.17786608
160activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.17696232
161embryonic foregut morphogenesis (GO:0048617)2.17604791
162endothelial tube morphogenesis (GO:0061154)2.16293613
163morphogenesis of an endothelium (GO:0003159)2.16293613
164translational elongation (GO:0006414)2.15672915
165positive regulation of response to tumor cell (GO:0002836)2.15146902
166positive regulation of immune response to tumor cell (GO:0002839)2.15146902
167regulation of immune response to tumor cell (GO:0002837)2.15146902
168regulation of response to tumor cell (GO:0002834)2.15146902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.71899338
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.77576338
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.76669666
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.55631865
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.26008645
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.04942323
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.83629400
8AR_21909140_ChIP-Seq_LNCAP_Human2.81905018
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78854300
10CLOCK_20551151_ChIP-Seq_293T_Human2.67425936
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.64346339
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29612283
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15067731
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08617765
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.07056070
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06415116
17ZNF263_19887448_ChIP-Seq_K562_Human2.04392681
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.01705157
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96767172
20MYC_22102868_ChIP-Seq_BL_Human1.94419190
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.93743526
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93112341
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.92103173
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89379392
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86686660
26NANOG_16153702_ChIP-ChIP_HESCs_Human1.84519153
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.83805776
28NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.83605096
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.83045414
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.81688628
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78694510
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78402800
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.74620148
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74610857
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71223795
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70773130
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70604275
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70604275
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66679579
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65950857
41ATF3_27146783_Chip-Seq_COLON_Human1.64173372
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62126046
43* FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61483187
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.61119807
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55884757
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55202317
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54073787
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52625541
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51994076
50NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51199155
51SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50198229
52TCF3_18692474_ChIP-Seq_MESCs_Mouse1.50002733
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49046281
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47403635
55EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.46956179
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.46835849
57SOX17_20123909_ChIP-Seq_XEN_Mouse1.46172173
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44177714
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42974097
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39308819
61ELK1_19687146_ChIP-ChIP_HELA_Human1.37865361
62* BRD4_25478319_ChIP-Seq_HGPS_Human1.36057701
63XRN2_22483619_ChIP-Seq_HELA_Human1.35718370
64* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35511368
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35498810
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.34992417
67* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34580054
68TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34151389
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32448288
70UBF1/2_26484160_Chip-Seq_HMECs_Human1.32283491
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32236382
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.32228431
73* CHD1_26751641_Chip-Seq_LNCaP_Human1.29866326
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28995643
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28234147
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27117708
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24156287
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23130968
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22916272
80DCP1A_22483619_ChIP-Seq_HELA_Human1.21904800
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21635709
82* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.20231138
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17552378
84NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.17246288
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16855577
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16807961
87TTF2_22483619_ChIP-Seq_HELA_Human1.16610753
88ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15761493
89* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15503866
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14935611
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13491325
92NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13444405
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.12337821
94SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12260252
95GATA6_25053715_ChIP-Seq_YYC3_Human1.11948320
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11510317
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11434779
98NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11146548
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10788140
100* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10647450
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09946479
102MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09233177
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09178014
104* WT1_19549856_ChIP-ChIP_CCG9911_Human1.08692375
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07693092
106* ELK1_22589737_ChIP-Seq_MCF10A_Human1.07401555
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06138181
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05879578
109* KDM2B_26808549_Chip-Seq_DND41_Human1.05351971
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03668952
111RACK7_27058665_Chip-Seq_MCF-7_Human1.03535786
112TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03372798
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03326883
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02988563
115* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02678815
116CJUN_26792858_Chip-Seq_BT549_Human1.02136444
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01863796
118TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01630554
119* EP300_21415370_ChIP-Seq_HL-1_Mouse1.01579395
120CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99691791
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.99470654
122KDM5A_27292631_Chip-Seq_BREAST_Human0.99256664
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98789341
124KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98430575
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98430575
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98430575
127PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98110663
128MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97214909
129NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97094842
130MAF_26560356_Chip-Seq_TH1_Human0.95264272
131TCF7_22412390_ChIP-Seq_EML_Mouse0.93614348
132FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93121370
133EST1_17652178_ChIP-ChIP_JURKAT_Human0.92104886
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91228226
135HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91163720
136TBX20_22328084_ChIP-Seq_HEART_Mouse0.91158266

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.44658223
2MP0010352_gastrointestinal_tract_polyps3.11698240
3MP0005623_abnormal_meninges_morphology2.94689039
4MP0008438_abnormal_cutaneous_collagen2.70181357
5MP0003566_abnormal_cell_adhesion2.39985667
6MP0002254_reproductive_system_inflammat2.37242452
7MP0004185_abnormal_adipocyte_glucose2.35360584
8MP0004957_abnormal_blastocyst_morpholog2.34617680
9MP0003950_abnormal_plasma_membrane2.21969755
10MP0004272_abnormal_basement_membrane2.19161414
11MP0003091_abnormal_cell_migration2.17528424
12MP0003890_abnormal_embryonic-extraembry2.09477116
13MP0000733_abnormal_muscle_development2.07730652
14MP0005257_abnormal_intraocular_pressure1.94141766
15MP0001730_embryonic_growth_arrest1.88058637
16MP0001299_abnormal_eye_distance/1.85357127
17MP0010234_abnormal_vibrissa_follicle1.85211984
18MP0000537_abnormal_urethra_morphology1.83879522
19MP0004084_abnormal_cardiac_muscle1.77402111
20MP0009384_cardiac_valve_regurgitation1.74023673
21MP0003077_abnormal_cell_cycle1.66759320
22MP0009053_abnormal_anal_canal1.65404598
23MP0005076_abnormal_cell_differentiation1.63847352
24MP0009672_abnormal_birth_weight1.61812815
25MP0002877_abnormal_melanocyte_morpholog1.58882359
26MP0000762_abnormal_tongue_morphology1.54255537
27MP0005275_abnormal_skin_tensile1.52014253
28MP0000750_abnormal_muscle_regeneration1.50995897
29MP0005023_abnormal_wound_healing1.50877990
30MP0003984_embryonic_growth_retardation1.48472421
31MP0002088_abnormal_embryonic_growth/wei1.46548684
32MP0002796_impaired_skin_barrier1.45648677
33MP0002060_abnormal_skin_morphology1.45565535
34MP0002697_abnormal_eye_size1.44752174
35MP0001672_abnormal_embryogenesis/_devel1.44103658
36MP0005380_embryogenesis_phenotype1.44103658
37MP0003567_abnormal_fetal_cardiomyocyte1.44069172
38MP0008058_abnormal_DNA_repair1.41483700
39MP0010368_abnormal_lymphatic_system1.39309998
40MP0000350_abnormal_cell_proliferation1.38292257
41MP0002084_abnormal_developmental_patter1.38049008
42MP0002086_abnormal_extraembryonic_tissu1.37369943
43MP0003453_abnormal_keratinocyte_physiol1.36752523
44MP0001293_anophthalmia1.36222339
45MP0004197_abnormal_fetal_growth/weight/1.36020938
46MP0001697_abnormal_embryo_size1.34376774
47MP0004087_abnormal_muscle_fiber1.34120028
48MP0008932_abnormal_embryonic_tissue1.31282160
49MP0002085_abnormal_embryonic_tissue1.30850860
50MP0003221_abnormal_cardiomyocyte_apopto1.30309620
51MP0000751_myopathy1.30168643
52MP0000579_abnormal_nail_morphology1.30055632
53MP0003693_abnormal_embryo_hatching1.28403803
54MP0009697_abnormal_copulation1.28005061
55MP0003937_abnormal_limbs/digits/tail_de1.27015714
56MP0010630_abnormal_cardiac_muscle1.26499722
57MP0003111_abnormal_nucleus_morphology1.24895537
58MP0001348_abnormal_lacrimal_gland1.24389155
59MP0001915_intracranial_hemorrhage1.23551301
60MP0003279_aneurysm1.21335609
61MP0003123_paternal_imprinting1.21196068
62MP0001849_ear_inflammation1.20395977
63MP0001542_abnormal_bone_strength1.19892160
64MP0004510_myositis1.18617288
65MP0003941_abnormal_skin_development1.17235346
66MP0005666_abnormal_adipose_tissue1.16616546
67MP0010094_abnormal_chromosome_stability1.14957463
68MP0003828_pulmonary_edema1.12600216
69MP0000767_abnormal_smooth_muscle1.11321832
70* MP0002080_prenatal_lethality1.11128951
71MP0005330_cardiomyopathy1.08939998
72MP0008007_abnormal_cellular_replicative1.06572419
73MP0006138_congestive_heart_failure1.05212077
74MP0001286_abnormal_eye_development1.04744364
75MP0003300_gastrointestinal_ulcer1.04221116
76MP0001958_emphysema1.03480107
77MP0003755_abnormal_palate_morphology1.01870136
78MP0009703_decreased_birth_body1.01734246
79MP0003119_abnormal_digestive_system0.99382644
80MP0010307_abnormal_tumor_latency0.98138247
81MP0001188_hyperpigmentation0.97222213
82MP0002925_abnormal_cardiovascular_devel0.95882976
83MP0002111_abnormal_tail_morphology0.95810468
84MP0003646_muscle_fatigue0.94918700
85MP0003942_abnormal_urinary_system0.94383717
86MP0002233_abnormal_nose_morphology0.94157868
87MP0000858_altered_metastatic_potential0.93988138
88MP0010030_abnormal_orbit_morphology0.92327993
89MP0003115_abnormal_respiratory_system0.91961626
90MP0003448_altered_tumor_morphology0.91951892
91MP0006054_spinal_hemorrhage0.91863415
92MP0001727_abnormal_embryo_implantation0.89297231
93MP0002282_abnormal_trachea_morphology0.89025079
94MP0003385_abnormal_body_wall0.88876463
95MP0000428_abnormal_craniofacial_morphol0.88747607
96MP0005395_other_phenotype0.87337585
97MP0005375_adipose_tissue_phenotype0.86995029
98MP0009250_abnormal_appendicular_skeleto0.86803751
99MP0002128_abnormal_blood_circulation0.86768000
100MP0000049_abnormal_middle_ear0.86068845
101MP0009333_abnormal_splenocyte_physiolog0.85408555
102MP0003935_abnormal_craniofacial_develop0.85385471
103MP0002138_abnormal_hepatobiliary_system0.85064574
104MP0001614_abnormal_blood_vessel0.85004479
105MP0002168_other_aberrant_phenotype0.84851628
106MP0000749_muscle_degeneration0.84816675
107MP0000462_abnormal_digestive_system0.83898703
108MP0003718_maternal_effect0.83503251
109MP0004808_abnormal_hematopoietic_stem0.82966972
110MP0002108_abnormal_muscle_morphology0.82638267
111MP0001544_abnormal_cardiovascular_syste0.81715577
112MP0005385_cardiovascular_system_phenoty0.81715577
113MP0000490_abnormal_crypts_of0.81065260
114MP0000266_abnormal_heart_morphology0.80549568
115MP0000534_abnormal_ureter_morphology0.80270901
116MP0001661_extended_life_span0.79749971
117MP0002106_abnormal_muscle_physiology0.78277735
118MP0005197_abnormal_uvea_morphology0.77815337
119MP0002019_abnormal_tumor_incidence0.77145437
120MP0008057_abnormal_DNA_replication0.76296766
121MP0005621_abnormal_cell_physiology0.76214573
122MP0000432_abnormal_head_morphology0.75930585
123MP0004233_abnormal_muscle_weight0.75903307
124MP0002269_muscular_atrophy0.75675472
125MP0010678_abnormal_skin_adnexa0.75501571
126MP0005508_abnormal_skeleton_morphology0.74195832
127MP0002092_abnormal_eye_morphology0.73092167
128MP0001243_abnormal_dermal_layer0.72384581
129MP0005501_abnormal_skin_physiology0.71027037
130MP0001784_abnormal_fluid_regulation0.70977672
131MP0005503_abnormal_tendon_morphology0.70873944
132MP0002295_abnormal_pulmonary_circulatio0.70800976
133MP0000759_abnormal_skeletal_muscle0.66695334

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.47659657
2Protrusio acetabuli (HP:0003179)4.01692752
3Multiple enchondromatosis (HP:0005701)3.60945006
4Ankle contracture (HP:0006466)3.09659518
5Shallow orbits (HP:0000586)3.09638263
6Difficulty climbing stairs (HP:0003551)3.01767737
7Broad metatarsal (HP:0001783)2.86254522
8Increased connective tissue (HP:0009025)2.84670554
9Right ventricular cardiomyopathy (HP:0011663)2.83220286
10Cerebral aneurysm (HP:0004944)2.79368915
11Muscle fiber splitting (HP:0003555)2.73765110
12Aortic aneurysm (HP:0004942)2.73305712
13Abnormality of the calcaneus (HP:0008364)2.71491250
14Aortic dissection (HP:0002647)2.65293888
15Coronal craniosynostosis (HP:0004440)2.64219835
16Increased density of long bones (HP:0006392)2.63036116
17Arterial tortuosity (HP:0005116)2.57463831
18Abnormal cartilage morphology (HP:0002763)2.53974654
19Spastic diplegia (HP:0001264)2.53755415
20Scapular winging (HP:0003691)2.52933819
21Short nail (HP:0001799)2.52546711
22Small epiphyses (HP:0010585)2.46199922
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.45184723
24Genu recurvatum (HP:0002816)2.44292868
25Abnormality of dentin (HP:0010299)2.43071966
26Ulnar bowing (HP:0003031)2.42906248
27Osteolytic defects of the phalanges of the hand (HP:0009771)2.41947492
28Osteolytic defects of the hand bones (HP:0009699)2.41947492
29Abnormal hemoglobin (HP:0011902)2.35973965
30Mitral valve prolapse (HP:0001634)2.35155196
31Peritonitis (HP:0002586)2.33842431
32Bladder diverticulum (HP:0000015)2.32087129
33Achilles tendon contracture (HP:0001771)2.28726328
34Wrist flexion contracture (HP:0001239)2.27701735
35Cervical subluxation (HP:0003308)2.23591448
36Metaphyseal cupping (HP:0003021)2.21403720
37Colon cancer (HP:0003003)2.21183897
38Muscle fiber inclusion bodies (HP:0100299)2.20513926
39Subacute progressive viral hepatitis (HP:0006572)2.19061290
40Bowel diverticulosis (HP:0005222)2.18277387
41Dilatation of the ascending aorta (HP:0005111)2.17963780
42Follicular hyperkeratosis (HP:0007502)2.17882252
43Hyporeflexia of lower limbs (HP:0002600)2.17858865
44Embryonal renal neoplasm (HP:0011794)2.15469188
45Fused cervical vertebrae (HP:0002949)2.15084934
46Slender build (HP:0001533)2.14457470
47Nephroblastoma (Wilms tumor) (HP:0002667)2.14277161
48Fragile skin (HP:0001030)2.12203860
49Increased mean platelet volume (HP:0011877)2.12169621
50Overgrowth (HP:0001548)2.10794034
51Trismus (HP:0000211)2.10070063
52Breast hypoplasia (HP:0003187)2.08140431
53Biliary tract neoplasm (HP:0100574)2.07918040
54Nemaline bodies (HP:0003798)2.06918921
55Flat acetabular roof (HP:0003180)2.06561781
56Radial bowing (HP:0002986)2.05063284
57Pelvic girdle muscle weakness (HP:0003749)2.05030319
58Breech presentation (HP:0001623)2.04371616
59Chromsome breakage (HP:0040012)2.04262009
60Deviation of the thumb (HP:0009603)2.04045552
61Limb-girdle muscle weakness (HP:0003325)2.03637593
62Missing ribs (HP:0000921)2.03631382
63Vertebral clefting (HP:0008428)2.03341064
64Wormian bones (HP:0002645)2.02796328
65Abnormality of the Achilles tendon (HP:0005109)2.02732752
66Soft skin (HP:0000977)2.02141957
67Blue sclerae (HP:0000592)2.00815194
68Pterygium (HP:0001059)2.00559182
69Shoulder girdle muscle weakness (HP:0003547)2.00544395
70Glossoptosis (HP:0000162)1.98433174
71Abnormal vertebral ossification (HP:0100569)1.97807994
72Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95536411
73Camptodactyly of toe (HP:0001836)1.94167158
74Tibial bowing (HP:0002982)1.93630900
75Cupped ribs (HP:0000887)1.93536732
76Cortical dysplasia (HP:0002539)1.93063207
77Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92751081
78Natal tooth (HP:0000695)1.91737222
79Neoplasm of the rectum (HP:0100743)1.90772408
80Exostoses (HP:0100777)1.90396480
81Back pain (HP:0003418)1.90392961
82Atrophic scars (HP:0001075)1.90076511
83Abnormality of the labia minora (HP:0012880)1.89596230
84Rectal prolapse (HP:0002035)1.89400101
85Bowed forearm bones (HP:0003956)1.88873756
86Bowing of the arm (HP:0006488)1.88873756
87Increased nuchal translucency (HP:0010880)1.88177273
88Spinal rigidity (HP:0003306)1.87974781
89Abnormality of the umbilical cord (HP:0010881)1.86852498
90Neonatal short-limb short stature (HP:0008921)1.85593348
91Aneurysm (HP:0002617)1.83469902
92Neoplasm of the colon (HP:0100273)1.83310079
93Ependymoma (HP:0002888)1.82640702
94Abnormal lung lobation (HP:0002101)1.82508366
95Stillbirth (HP:0003826)1.82015283
96Limb-girdle muscle atrophy (HP:0003797)1.81205579
97Round ear (HP:0100830)1.81150926
98Abnormality of the peritoneum (HP:0002585)1.81141499
99Elbow flexion contracture (HP:0002987)1.81072960
100Choanal stenosis (HP:0000452)1.81044176
101Type 1 muscle fiber predominance (HP:0003803)1.80310585
102Selective tooth agenesis (HP:0001592)1.79216508
103Chin dimple (HP:0010751)1.79187736
104Abnormal platelet volume (HP:0011876)1.77974265
105Knee flexion contracture (HP:0006380)1.77157143
106Delayed epiphyseal ossification (HP:0002663)1.77115888
107Abnormality of the shoulder girdle musculature (HP:0001435)1.77043153
108Abnormality of the musculature of the pelvis (HP:0001469)1.75217477
109Abnormality of the hip-girdle musculature (HP:0001445)1.75217477
110Lymphangioma (HP:0100764)1.75136481
111Septo-optic dysplasia (HP:0100842)1.75102639
112Mildly elevated creatine phosphokinase (HP:0008180)1.73942460
113Short humerus (HP:0005792)1.73726205
114Epiphyseal dysplasia (HP:0002656)1.73391375
115Gastrointestinal carcinoma (HP:0002672)1.72251624
116Malignant gastrointestinal tract tumors (HP:0006749)1.72251624
117Deformed tarsal bones (HP:0008119)1.71557183
118Thin ribs (HP:0000883)1.71438566
119Stenosis of the external auditory canal (HP:0000402)1.70416075
120Persistence of primary teeth (HP:0006335)1.69549168
121Generalized amyotrophy (HP:0003700)1.69221147
122Arnold-Chiari malformation (HP:0002308)1.68717094
123Thin bony cortex (HP:0002753)1.68271697
124Delayed cranial suture closure (HP:0000270)1.67805420
125Absent eyelashes (HP:0000561)1.65662237
126Cutaneous melanoma (HP:0012056)1.65553114
127Neoplasm of the small intestine (HP:0100833)1.65257394
128Abnormalities of placenta or umbilical cord (HP:0001194)1.65061988
129Focal segmental glomerulosclerosis (HP:0000097)1.63467625
130Hyperextensible skin (HP:0000974)1.63386912
131Aplasia/hypoplasia of the humerus (HP:0006507)1.62897813
132EMG: myopathic abnormalities (HP:0003458)1.62568385
133Sudden death (HP:0001699)1.62002545
134Myelomeningocele (HP:0002475)1.61949046
135Vascular tortuosity (HP:0004948)1.61693222
136Proximal placement of thumb (HP:0009623)1.61237454
137Deep palmar crease (HP:0006191)1.60764456
138Bifid tongue (HP:0010297)1.60755572
139Facial cleft (HP:0002006)1.60724978
140Distal lower limb muscle weakness (HP:0009053)1.60697391
141Biconcave vertebral bodies (HP:0004586)1.60286173
142Popliteal pterygium (HP:0009756)1.59681464
143Microglossia (HP:0000171)1.59508768
144Entropion (HP:0000621)1.58738040
145Vertebral hypoplasia (HP:0008417)1.58690155
146Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.58690155
147Abnormality of the proximal phalanges of the hand (HP:0009834)1.58452317
148Calcaneovalgus deformity (HP:0001848)1.58346449
149Abnormal foot bone ossification (HP:0010675)1.58301082
150Progressive muscle weakness (HP:0003323)1.58144768
151Abnormal delivery (HP:0001787)1.58040205
152Abnormal ossification of hand bones (HP:0005921)1.58011997
153Spinal cord lesions (HP:0100561)1.57370440
154Syringomyelia (HP:0003396)1.57370440
155Rhabdomyosarcoma (HP:0002859)1.56821883
156Joint laxity (HP:0001388)1.56681623
157Abnormality of abdominal situs (HP:0011620)1.56333479
158Abdominal situs inversus (HP:0003363)1.56333479
159Increased variability in muscle fiber diameter (HP:0003557)1.55211757
160Abnormality of the septum pellucidum (HP:0007375)1.54949316
161Abnormality of skeletal muscle fiber size (HP:0012084)1.54763957
162Cardiovascular calcification (HP:0011915)1.54665671
163Short hallux (HP:0010109)1.53369795
164Uterine neoplasm (HP:0010784)1.53173725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.36634026
2PKN23.29977384
3TTN3.22424035
4TRIB33.02825351
5TSSK62.92701651
6EPHA22.87523313
7EEF2K2.65106885
8NME22.44488910
9RPS6KB22.41541353
10LATS22.33805053
11STK102.33522237
12PLK32.08354084
13STK32.08081568
14SRPK12.06880893
15MST41.89682993
16MKNK21.88476071
17MAP3K101.84558710
18MYLK1.79980367
19DMPK1.77827855
20RPS6KA41.73494368
21LRRK21.70115703
22EIF2AK31.69134294
23MKNK11.61340838
24STK38L1.60410979
25TAF11.56315429
26MELK1.52998262
27MAP3K91.50803593
28TYRO31.48469251
29MAP3K81.47711132
30LIMK11.40956637
31NEK21.39822020
32PAK41.33806973
33STK161.33146121
34MOS1.26145209
35PAK21.24873285
36EPHB11.24731735
37SMG11.24621163
38ZAK1.24302368
39STK391.19894188
40NEK91.19104311
41TNIK1.16373593
42CDK121.12655972
43CDC71.12624260
44PTK21.11652601
45VRK21.11241928
46EIF2AK11.08134325
47CDK41.07214693
48MET1.07028637
49DDR21.06664816
50TTK1.05846508
51MAP3K121.05323996
52BMX1.04862905
53NLK1.04327573
54PDGFRA1.04187999
55BRAF1.03604782
56ERBB41.03354922
57NTRK11.02768435
58EPHB21.00592925
59WEE11.00529145
60ILK0.99590783
61TESK10.97749327
62ACVR1B0.97508035
63PAK30.96364225
64STK40.96104287
65PTK60.95151737
66SCYL20.94459546
67ROCK10.89341997
68STK240.89338979
69CDK60.89172076
70MTOR0.88715645
71ALK0.88109545
72TGFBR10.85107183
73BCR0.81894175
74AURKB0.81634849
75CDK190.76970699
76KSR20.75901145
77JAK30.74817930
78TRIM280.74068435
79CDK90.72524469
80FLT30.72360361
81ARAF0.72336242
82PIM10.71894045
83MAP3K30.71853542
84PNCK0.70833457
85FGR0.69476154
86PDGFRB0.67375675
87BUB10.66035253
88ROCK20.64809449
89BRSK10.64729712
90ABL20.64499468
91TRPM70.63215918
92FGFR40.62129048
93CSK0.62038446
94FGFR10.61758288
95FER0.61602406
96PRKG20.61413863
97PAK10.60544129
98TGFBR20.60294317
99NUAK10.60032929
100BRD40.58338331
101EIF2AK20.57867718
102VRK10.55327057
103CHEK20.55148816
104MUSK0.54793426
105FRK0.54319506
106KSR10.54183363
107ATM0.54054829
108CHEK10.53744935
109MAP3K50.53434135
110PLK10.51682632
111TBK10.50166192
112INSR0.49848392
113ICK0.49763198
114PLK40.49596304
115PBK0.48843063
116ATR0.48652010
117RET0.46890851
118MAP2K10.45283445
119DYRK20.45238644
120NEK10.44730317
121DYRK30.43079001
122CDK70.41962964
123MAPKAPK30.41791703
124TIE10.39637178
125MST1R0.39478153
126IKBKB0.39371218
127AKT20.39078239
128BRSK20.38889164
129PASK0.37780088
130CDK10.37710939
131PDK20.37523053
132MAP3K60.36468546
133AURKA0.36396794
134RIPK10.36273554

Predicted pathways (KEGG)

RankGene SetZ-score
1Small cell lung cancer_Homo sapiens_hsa052222.34056670
2Viral myocarditis_Homo sapiens_hsa054162.20298318
3Adherens junction_Homo sapiens_hsa045202.03557978
4Focal adhesion_Homo sapiens_hsa045102.02009461
5ECM-receptor interaction_Homo sapiens_hsa045121.95385567
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90476017
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.90060615
8RNA transport_Homo sapiens_hsa030131.87606779
9MicroRNAs in cancer_Homo sapiens_hsa052061.87424527
10Cysteine and methionine metabolism_Homo sapiens_hsa002701.86905310
11p53 signaling pathway_Homo sapiens_hsa041151.82586871
12Hippo signaling pathway_Homo sapiens_hsa043901.79499738
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.78524472
14Cell cycle_Homo sapiens_hsa041101.78252611
15Selenocompound metabolism_Homo sapiens_hsa004501.77844450
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77169153
17TGF-beta signaling pathway_Homo sapiens_hsa043501.76943447
18Chronic myeloid leukemia_Homo sapiens_hsa052201.64122556
19Shigellosis_Homo sapiens_hsa051311.63831952
20Vitamin B6 metabolism_Homo sapiens_hsa007501.62222760
21Biosynthesis of amino acids_Homo sapiens_hsa012301.61399411
22* Proteoglycans in cancer_Homo sapiens_hsa052051.60013216
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.53015575
24Pancreatic cancer_Homo sapiens_hsa052121.50918671
25Renal cell carcinoma_Homo sapiens_hsa052111.44842319
26Pyruvate metabolism_Homo sapiens_hsa006201.40561721
27* Tight junction_Homo sapiens_hsa045301.39824045
28Ribosome_Homo sapiens_hsa030101.37489521
29Viral carcinogenesis_Homo sapiens_hsa052031.37404543
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33727038
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32467492
32Colorectal cancer_Homo sapiens_hsa052101.31623471
33Bladder cancer_Homo sapiens_hsa052191.26388383
34Prostate cancer_Homo sapiens_hsa052151.25590694
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23639620
36Amoebiasis_Homo sapiens_hsa051461.23248748
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.23088800
38Toxoplasmosis_Homo sapiens_hsa051451.22393203
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21420538
40Apoptosis_Homo sapiens_hsa042101.20798730
41RNA polymerase_Homo sapiens_hsa030201.16903379
42* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15705836
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15133129
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13978947
45Proteasome_Homo sapiens_hsa030501.13470766
46Carbon metabolism_Homo sapiens_hsa012001.10699055
47mTOR signaling pathway_Homo sapiens_hsa041501.10305547
48Thyroid cancer_Homo sapiens_hsa052161.08629905
49* HTLV-I infection_Homo sapiens_hsa051661.08505263
50Acute myeloid leukemia_Homo sapiens_hsa052211.08245184
51One carbon pool by folate_Homo sapiens_hsa006701.07424802
52Epstein-Barr virus infection_Homo sapiens_hsa051691.06224630
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05952299
54Protein export_Homo sapiens_hsa030601.05753242
55mRNA surveillance pathway_Homo sapiens_hsa030151.05300949
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03054414
57Steroid biosynthesis_Homo sapiens_hsa001001.02386888
58Spliceosome_Homo sapiens_hsa030401.01015094
59Galactose metabolism_Homo sapiens_hsa000521.00427475
60Wnt signaling pathway_Homo sapiens_hsa043100.99592669
61B cell receptor signaling pathway_Homo sapiens_hsa046620.96756806
62Endometrial cancer_Homo sapiens_hsa052130.95226941
63Pyrimidine metabolism_Homo sapiens_hsa002400.94443729
64Fanconi anemia pathway_Homo sapiens_hsa034600.93073028
65Dilated cardiomyopathy_Homo sapiens_hsa054140.92890506
66VEGF signaling pathway_Homo sapiens_hsa043700.92668293
67Nucleotide excision repair_Homo sapiens_hsa034200.92257470
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.92127153
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92029229
70DNA replication_Homo sapiens_hsa030300.91826900
71HIF-1 signaling pathway_Homo sapiens_hsa040660.91159642
72Hepatitis B_Homo sapiens_hsa051610.90995734
73Folate biosynthesis_Homo sapiens_hsa007900.90133686
74Hedgehog signaling pathway_Homo sapiens_hsa043400.89274749
75Systemic lupus erythematosus_Homo sapiens_hsa053220.89187360
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88494744
77Platelet activation_Homo sapiens_hsa046110.84696728
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.84231518
79Antigen processing and presentation_Homo sapiens_hsa046120.83173688
80Pentose phosphate pathway_Homo sapiens_hsa000300.82419247
81Pathways in cancer_Homo sapiens_hsa052000.81809523
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81523572
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80494601
84Non-homologous end-joining_Homo sapiens_hsa034500.80478810
85Basal cell carcinoma_Homo sapiens_hsa052170.79803473
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79733075
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.78973247
88T cell receptor signaling pathway_Homo sapiens_hsa046600.77839153
89Axon guidance_Homo sapiens_hsa043600.75322121
90Glutathione metabolism_Homo sapiens_hsa004800.75137878
91Melanoma_Homo sapiens_hsa052180.73860122
92FoxO signaling pathway_Homo sapiens_hsa040680.72962980
93Non-small cell lung cancer_Homo sapiens_hsa052230.72741620
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70790790
95RNA degradation_Homo sapiens_hsa030180.70780513
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70654589
97Basal transcription factors_Homo sapiens_hsa030220.70591440
98Measles_Homo sapiens_hsa051620.69705114
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67517271
100Propanoate metabolism_Homo sapiens_hsa006400.67362550
101TNF signaling pathway_Homo sapiens_hsa046680.67162847
102Vitamin digestion and absorption_Homo sapiens_hsa049770.66606270
103Herpes simplex infection_Homo sapiens_hsa051680.66338792
104Arginine and proline metabolism_Homo sapiens_hsa003300.66224414
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64535309
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64361752
107Salmonella infection_Homo sapiens_hsa051320.64263863
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63844410
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63621106
110Purine metabolism_Homo sapiens_hsa002300.62435776
111Lysine degradation_Homo sapiens_hsa003100.62224531
112AMPK signaling pathway_Homo sapiens_hsa041520.61591904
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60745235
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60212485
115Mismatch repair_Homo sapiens_hsa034300.59952768
116N-Glycan biosynthesis_Homo sapiens_hsa005100.59862756
117Glioma_Homo sapiens_hsa052140.59706298
118Sulfur metabolism_Homo sapiens_hsa009200.58720721
119Starch and sucrose metabolism_Homo sapiens_hsa005000.57133052
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56988859
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56294307
122Renin-angiotensin system_Homo sapiens_hsa046140.55860836
123Primary immunodeficiency_Homo sapiens_hsa053400.54856406
124Malaria_Homo sapiens_hsa051440.54024549
125Legionellosis_Homo sapiens_hsa051340.51813457
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50143738
127Base excision repair_Homo sapiens_hsa034100.49557639
128Arginine biosynthesis_Homo sapiens_hsa002200.49551927
129Osteoclast differentiation_Homo sapiens_hsa043800.49499232
130Endocytosis_Homo sapiens_hsa041440.49179554
131Oocyte meiosis_Homo sapiens_hsa041140.49147343
132Insulin resistance_Homo sapiens_hsa049310.47997632
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46027257
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45810443
135Leishmaniasis_Homo sapiens_hsa051400.45279487
136Protein digestion and absorption_Homo sapiens_hsa049740.45016797
137Homologous recombination_Homo sapiens_hsa034400.44161884
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.43316585
139Rap1 signaling pathway_Homo sapiens_hsa040150.42930808
140Gap junction_Homo sapiens_hsa045400.39900794
141Fatty acid elongation_Homo sapiens_hsa000620.39240876
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38857543
143Caffeine metabolism_Homo sapiens_hsa002320.38077666
144Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37203400

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