RRAGD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of glucokinase activity (GO:0033131)4.99844249
2regulation of hexokinase activity (GO:1903299)4.99844249
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.91309235
4membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.59015455
5synaptic vesicle maturation (GO:0016188)4.43254666
6regulation of synapse structural plasticity (GO:0051823)4.32826416
7locomotory exploration behavior (GO:0035641)4.24950791
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.24934842
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.23455503
10positive regulation of glycolytic process (GO:0045821)4.22396658
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.09749288
12vocalization behavior (GO:0071625)4.09720058
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.08422081
14inositol phosphate catabolic process (GO:0071545)3.97403041
15striatum development (GO:0021756)3.93971461
16fatty acid homeostasis (GO:0055089)3.93936958
17insulin secretion (GO:0030073)3.92174539
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.89886239
19synaptic vesicle exocytosis (GO:0016079)3.87021723
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.87017096
21neuronal action potential propagation (GO:0019227)3.83145251
22regulation of glutamate receptor signaling pathway (GO:1900449)3.78760724
23regulation of membrane repolarization (GO:0060306)3.75127309
24ketone body metabolic process (GO:1902224)3.74559354
25cell communication by electrical coupling (GO:0010644)3.74231412
26regulation of relaxation of muscle (GO:1901077)3.74077120
27righting reflex (GO:0060013)3.74029281
28regulation of synaptic vesicle exocytosis (GO:2000300)3.73829498
29negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.67507982
30regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.65666490
31nitric oxide mediated signal transduction (GO:0007263)3.62430309
32sarcoplasmic reticulum calcium ion transport (GO:0070296)3.61517791
33regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.61195507
34negative regulation of protein oligomerization (GO:0032460)3.60468777
35astrocyte differentiation (GO:0048708)3.59951752
36regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.58836754
37layer formation in cerebral cortex (GO:0021819)3.54252107
38regulation of synaptic vesicle transport (GO:1902803)3.54020155
39glutamate secretion (GO:0014047)3.53343592
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.51607732
41regulation of neuronal synaptic plasticity (GO:0048168)3.46478299
42negative regulation of cytosolic calcium ion concentration (GO:0051481)3.46341840
43macroautophagy (GO:0016236)3.45930012
44negative regulation of potassium ion transmembrane transport (GO:1901380)3.44872240
45phosphorylated carbohydrate dephosphorylation (GO:0046838)3.42369748
46inositol phosphate dephosphorylation (GO:0046855)3.42369748
47cell communication involved in cardiac conduction (GO:0086065)3.41648704
48detection of calcium ion (GO:0005513)3.40772098
49negative regulation of acute inflammatory response (GO:0002674)3.38082621
50endocrine pancreas development (GO:0031018)3.37927689
51regulation of type B pancreatic cell apoptotic process (GO:2000674)3.37671235
52cellular ketone body metabolic process (GO:0046950)3.36386349
53regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.34724536
54positive regulation of synapse maturation (GO:0090129)3.29774833
55regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.28972463
56cardiac muscle contraction (GO:0060048)3.28703532
57protein localization to synapse (GO:0035418)3.26387642
58neurotransmitter secretion (GO:0007269)3.26286888
59regulation of energy homeostasis (GO:2000505)3.24963337
60membrane depolarization during action potential (GO:0086010)3.23891756
61cellular potassium ion homeostasis (GO:0030007)3.22729784
62plasma membrane repair (GO:0001778)3.22311178
63prepulse inhibition (GO:0060134)3.20223401
64dendritic spine morphogenesis (GO:0060997)3.19523256
65actin-myosin filament sliding (GO:0033275)3.19511452
66muscle filament sliding (GO:0030049)3.19511452
67startle response (GO:0001964)3.19445415
68regulation of dendritic spine morphogenesis (GO:0061001)3.18207561
69neuromuscular process controlling balance (GO:0050885)3.15824058
70membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.15351315
71activation of protein kinase A activity (GO:0034199)3.14410070
72regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.12553556
73long-term memory (GO:0007616)3.11243958
74auditory behavior (GO:0031223)3.11077133
75neurotransmitter-gated ion channel clustering (GO:0072578)3.10611421
76cardiac conduction (GO:0061337)3.10077969
77positive regulation of protein autophosphorylation (GO:0031954)3.09685953
78presynaptic membrane assembly (GO:0097105)3.09357694
79actin-mediated cell contraction (GO:0070252)3.08036944
80polyol catabolic process (GO:0046174)3.07900193
81cardiac myofibril assembly (GO:0055003)3.07059932
82exploration behavior (GO:0035640)3.07010965
83response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.05409756
84sodium ion export (GO:0071436)3.04862631
85positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04287986
86striated muscle contraction (GO:0006941)3.04149241
87neuron-neuron synaptic transmission (GO:0007270)3.03838993
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03195587
89ionotropic glutamate receptor signaling pathway (GO:0035235)3.02523327
90regulation of cell communication by electrical coupling (GO:0010649)3.00982792
91regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00149134
92synaptic transmission, glutamatergic (GO:0035249)2.99608915
93cardiac muscle cell action potential involved in contraction (GO:0086002)2.98680749
94regulation of calcium ion transmembrane transporter activity (GO:1901019)2.97354790
95regulation of calcium ion transmembrane transport (GO:1903169)2.97354790
96regulation of heart rate by cardiac conduction (GO:0086091)2.97244800
97positive regulation of potassium ion transmembrane transport (GO:1901381)2.96876424
98chemosensory behavior (GO:0007635)2.96026265
99sarcomere organization (GO:0045214)2.94280675
100negative regulation of neurological system process (GO:0031645)2.94227958
101cardiac muscle cell action potential (GO:0086001)2.94069409
102skeletal muscle contraction (GO:0003009)2.92184731
103regulation of skeletal muscle contraction (GO:0014819)2.92041415
104positive regulation of peptide hormone secretion (GO:0090277)2.91985891
105membrane repolarization (GO:0086009)2.90730209
106glycerophospholipid catabolic process (GO:0046475)2.90663778
107neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.89849445
108regulation of excitatory postsynaptic membrane potential (GO:0060079)2.89825401
109positive regulation of potassium ion transport (GO:0043268)2.88856443
110myofibril assembly (GO:0030239)2.88294632
111G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.87069411
112neuromuscular synaptic transmission (GO:0007274)2.85649013
113positive regulation of insulin secretion (GO:0032024)2.84312153
114cerebellar Purkinje cell differentiation (GO:0021702)2.83034966
115positive regulation of membrane potential (GO:0045838)2.82744505
116positive regulation of peptide secretion (GO:0002793)2.82682517
117ventricular cardiac muscle cell action potential (GO:0086005)2.81438379
118regulation of glycolytic process (GO:0006110)2.81325838
119proline transport (GO:0015824)2.80868847
120multicellular organismal signaling (GO:0035637)2.79895703
121presynaptic membrane organization (GO:0097090)2.79092126
122membrane repolarization during action potential (GO:0086011)2.78363724
123response to auditory stimulus (GO:0010996)2.77960307
124lactate metabolic process (GO:0006089)2.76925338
125cornea development in camera-type eye (GO:0061303)2.76456829
126regulation of postsynaptic membrane potential (GO:0060078)2.76297657
127adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.76266576
128regulation of ion transmembrane transporter activity (GO:0032412)2.75911845
129regulation of synaptic plasticity (GO:0048167)2.75744346
130regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.74732658
131regulation of potassium ion transmembrane transporter activity (GO:1901016)2.74411654
132prostate gland growth (GO:0060736)2.74266065
133glutamate receptor signaling pathway (GO:0007215)2.72856674
134regulation of potassium ion transmembrane transport (GO:1901379)2.72843561
135response to inactivity (GO:0014854)2.71585193
136transmission of nerve impulse (GO:0019226)2.70409104
137potassium ion import (GO:0010107)2.70115196
138vesicle transport along microtubule (GO:0047496)2.68937609
139positive regulation of respiratory burst (GO:0060267)2.68473173
140neuron cell-cell adhesion (GO:0007158)2.68421308
141positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.68046242
142negative regulation of dendrite development (GO:2000171)2.65822137
143negative regulation of gluconeogenesis (GO:0045721)2.65012996
144regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.64042647
145positive regulation of glycogen biosynthetic process (GO:0045725)2.59325632
146positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.55501474
147glandular epithelial cell differentiation (GO:0002067)2.53802126
148epithelial cell fate commitment (GO:0072148)2.53694669
149fructose metabolic process (GO:0006000)2.51791245
150brain morphogenesis (GO:0048854)2.51733020
151regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.50785550
152alanine transport (GO:0032328)2.50217865
153regulation of insulin secretion (GO:0050796)2.50061107
154dentate gyrus development (GO:0021542)2.49386137
155regulation of actin filament-based movement (GO:1903115)2.47099145
156water-soluble vitamin biosynthetic process (GO:0042364)2.46831464
157embryonic retina morphogenesis in camera-type eye (GO:0060059)2.46814534
158glycogen catabolic process (GO:0005980)2.46638885
159parental behavior (GO:0060746)2.46253407
160peptide hormone secretion (GO:0030072)2.45937542
161protein localization to cilium (GO:0061512)2.45205169
162response to lipoprotein particle (GO:0055094)2.45081818
163myotube differentiation (GO:0014902)2.44541111
164protein targeting to Golgi (GO:0000042)2.44103407
165negative regulation of hormone biosynthetic process (GO:0032353)2.43891632
166regulation of neurotransmitter uptake (GO:0051580)2.43695600
167lipid particle organization (GO:0034389)2.41286363
168peptide secretion (GO:0002790)2.40041614
169signal peptide processing (GO:0006465)2.39973888
170neuromuscular process controlling posture (GO:0050884)2.39485479
171pigment cell differentiation (GO:0050931)2.39251619
172regulation of protein glycosylation (GO:0060049)2.37359074
173cardiac muscle hypertrophy (GO:0003300)2.37226655
174establishment of protein localization to Golgi (GO:0072600)2.34685051
175negative regulation of glycogen metabolic process (GO:0070874)2.33661003
176regulation of peptide hormone secretion (GO:0090276)2.33143490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.77522806
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.46920541
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.20831801
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.81133165
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.72889582
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69762348
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.67361454
8GBX2_23144817_ChIP-Seq_PC3_Human2.64598633
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57520464
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57473240
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43995839
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43995839
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40591031
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.35823671
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.35293684
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.34924488
17DROSHA_22980978_ChIP-Seq_HELA_Human2.29521842
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29098433
19* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.27344120
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16654214
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13863805
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10635829
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10020007
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08715601
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.05186300
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01848210
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.99194199
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.98772798
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95147236
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94168730
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.92723381
32FUS_26573619_Chip-Seq_HEK293_Human1.86655671
33* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85819794
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.85743290
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.83010605
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.79840921
37IGF1R_20145208_ChIP-Seq_DFB_Human1.79220905
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.78479077
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77970463
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77313657
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74977397
42RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.74228921
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71841595
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63224448
45VDR_22108803_ChIP-Seq_LS180_Human1.60736279
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60047152
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.59978366
48ZNF274_21170338_ChIP-Seq_K562_Hela1.59789758
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.59752186
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.56934433
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.54067814
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52226927
53* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51063605
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49577524
55BCAT_22108803_ChIP-Seq_LS180_Human1.44814749
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44563641
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44350485
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.44317224
59SMAD4_21799915_ChIP-Seq_A2780_Human1.43461885
60HTT_18923047_ChIP-ChIP_STHdh_Human1.42492899
61ER_23166858_ChIP-Seq_MCF-7_Human1.42372032
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41335475
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39390884
64P53_22387025_ChIP-Seq_ESCs_Mouse1.38539346
65EWS_26573619_Chip-Seq_HEK293_Human1.37227166
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.36883408
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.35577986
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.35085005
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.34911928
70OCT4_21477851_ChIP-Seq_ESCs_Mouse1.34248460
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34048095
72CBP_20019798_ChIP-Seq_JUKART_Human1.34048095
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33189529
74AR_19668381_ChIP-Seq_PC3_Human1.30026894
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29145814
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.28886214
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26017973
78* RING1B_27294783_Chip-Seq_ESCs_Mouse1.25964335
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25151956
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23113792
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.23110380
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22863266
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22657613
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21962480
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21830395
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21038192
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20890240
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20870652
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.20372758
90KDM2B_26808549_Chip-Seq_K562_Human1.18881815
91RUNX2_22187159_ChIP-Seq_PCA_Human1.18079124
92* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17602863
93* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17592211
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17235019
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16970059
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16970059
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.16562868
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.15566224
99EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15541497
100AR_21572438_ChIP-Seq_LNCaP_Human1.15116048
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.14700706
102TBL1_22424771_ChIP-Seq_293T_Human1.14690415
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14618070
104NANOG_19829295_ChIP-Seq_ESCs_Human1.14556620
105SOX2_19829295_ChIP-Seq_ESCs_Human1.14556620
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14548214
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14041557
108STAT3_23295773_ChIP-Seq_U87_Human1.13464558
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13198991
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13116170
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.12418955
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12109303
113CDX2_22108803_ChIP-Seq_LS180_Human1.11820807
114P300_18555785_Chip-Seq_ESCs_Mouse1.11432719
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09404505
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09194255
117SOX2_18555785_Chip-Seq_ESCs_Mouse1.08718394
118* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08008706
119YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07771480
120SMAD3_21741376_ChIP-Seq_EPCs_Human1.07662563
121CTCF_27219007_Chip-Seq_Bcells_Human1.07349176
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06642070
123* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06217342
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05860466
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05702611
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05586484
127NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05586484
128RNF2_27304074_Chip-Seq_NSC_Mouse1.05484798
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05312765
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.04130940
131FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04091832
132ZNF263_19887448_ChIP-Seq_K562_Human1.04025129
133TCF4_22108803_ChIP-Seq_LS180_Human1.03492967
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02529185
135GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01910354
136CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00754406
137SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98629494
138TET1_21490601_ChIP-Seq_MESCs_Mouse0.97793076
139CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97196918
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.96761878
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95463102
142TCF4_23295773_ChIP-Seq_U87_Human0.94491906
143ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94263475
144AR_25329375_ChIP-Seq_VCAP_Human0.93452434
145SMAD3_21741376_ChIP-Seq_ESCs_Human0.92956405
146RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92716703
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92366080
148AHR_22903824_ChIP-Seq_MCF-7_Human0.91660274
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90986904
150BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90723535
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.89532026
152ISL1_27105846_Chip-Seq_CPCs_Mouse0.89206129
153TAF15_26573619_Chip-Seq_HEK293_Human0.88686733
154CBX2_27304074_Chip-Seq_ESCs_Mouse0.88458832
155ARNT_22903824_ChIP-Seq_MCF-7_Human0.87226794
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84107352
157IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83945617
158TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82053677
159P300_19829295_ChIP-Seq_ESCs_Human0.81603921
160WDR5_24793694_ChIP-Seq_LNCAP_Human0.81349042
161SOX9_26525672_Chip-Seq_HEART_Mouse0.81347731
162OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79585306
163TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.79322216
164OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79072245
165GATA1_26923725_Chip-Seq_HPCs_Mouse0.78976298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.86483917
2MP0002822_catalepsy4.05393880
3MP0004270_analgesia3.39604761
4MP0003195_calcinosis3.07020439
5MP0003635_abnormal_synaptic_transmissio3.02882017
6MP0003646_muscle_fatigue2.76745894
7MP0004145_abnormal_muscle_electrophysio2.76220048
8MP0003880_abnormal_central_pattern2.67744837
9MP0000751_myopathy2.63787547
10MP0000569_abnormal_digit_pigmentation2.59274562
11MP0002063_abnormal_learning/memory/cond2.51731771
12MP0009745_abnormal_behavioral_response2.50080703
13MP0002837_dystrophic_cardiac_calcinosis2.49255108
14MP0000372_irregular_coat_pigmentation2.34759653
15MP0004036_abnormal_muscle_relaxation2.17267353
16MP0004084_abnormal_cardiac_muscle2.16561005
17MP0009046_muscle_twitch2.14491629
18MP0002064_seizures2.13330105
19MP0000749_muscle_degeneration2.11814866
20MP0004215_abnormal_myocardial_fiber2.09664440
21MP0002734_abnormal_mechanical_nocicepti2.05096877
22MP0002572_abnormal_emotion/affect_behav1.93445234
23MP0002909_abnormal_adrenal_gland1.89659127
24MP0005075_abnormal_melanosome_morpholog1.87347385
25MP0005645_abnormal_hypothalamus_physiol1.84931918
26MP0003172_abnormal_lysosome_physiology1.82396598
27MP0005423_abnormal_somatic_nervous1.82114936
28MP0001968_abnormal_touch/_nociception1.80211307
29MP0001486_abnormal_startle_reflex1.77757499
30MP0002272_abnormal_nervous_system1.76210099
31MP0004510_myositis1.75966421
32MP0002102_abnormal_ear_morphology1.75753576
33MP0004233_abnormal_muscle_weight1.73259823
34MP0005620_abnormal_muscle_contractility1.71728155
35MP0001944_abnormal_pancreas_morphology1.69657137
36MP0005379_endocrine/exocrine_gland_phen1.64243963
37MP0002693_abnormal_pancreas_physiology1.64044460
38MP0000747_muscle_weakness1.61409867
39MP0003137_abnormal_impulse_conducting1.57880621
40MP0002106_abnormal_muscle_physiology1.55170678
41MP0002090_abnormal_vision1.54945506
42MP0009780_abnormal_chondrocyte_physiolo1.53076607
43MP0004924_abnormal_behavior1.53043604
44MP0005386_behavior/neurological_phenoty1.53043604
45MP0002938_white_spotting1.52708476
46MP0004043_abnormal_pH_regulation1.49903567
47MP0003879_abnormal_hair_cell1.49653866
48MP0008569_lethality_at_weaning1.49580231
49MP0001984_abnormal_olfaction1.49477899
50MP0001529_abnormal_vocalization1.48976944
51MP0001440_abnormal_grooming_behavior1.48799816
52MP0005174_abnormal_tail_pigmentation1.48578801
53MP0004087_abnormal_muscle_fiber1.47794072
54MP0004085_abnormal_heartbeat1.46233332
55MP0005171_absent_coat_pigmentation1.45302225
56MP0000015_abnormal_ear_pigmentation1.44941175
57MP0005253_abnormal_eye_physiology1.44935848
58MP0002269_muscular_atrophy1.43521340
59MP0002067_abnormal_sensory_capabilities1.43201019
60MP0002972_abnormal_cardiac_muscle1.40862340
61MP0004858_abnormal_nervous_system1.40492433
62MP0005257_abnormal_intraocular_pressure1.37640495
63MP0004484_altered_response_of1.36659427
64MP0005330_cardiomyopathy1.36354124
65MP0003136_yellow_coat_color1.35765434
66MP0004811_abnormal_neuron_physiology1.34607599
67MP0002163_abnormal_gland_morphology1.34492160
68MP0006072_abnormal_retinal_apoptosis1.34303366
69MP0001970_abnormal_pain_threshold1.34163083
70MP0002184_abnormal_innervation1.33157365
71MP0008877_abnormal_DNA_methylation1.31169465
72MP0002733_abnormal_thermal_nociception1.31156114
73MP0003121_genomic_imprinting1.30785398
74MP0005369_muscle_phenotype1.30424118
75MP0002078_abnormal_glucose_homeostasis1.30161641
76MP0002557_abnormal_social/conspecific_i1.28777566
77MP0002735_abnormal_chemical_nociception1.27889561
78MP0001501_abnormal_sleep_pattern1.26653708
79MP0000778_abnormal_nervous_system1.25423699
80MP0005499_abnormal_olfactory_system1.25260020
81MP0005394_taste/olfaction_phenotype1.25260020
82MP0000759_abnormal_skeletal_muscle1.23396893
83MP0005646_abnormal_pituitary_gland1.22523757
84MP0002234_abnormal_pharynx_morphology1.21028014
85MP0001324_abnormal_eye_pigmentation1.20919367
86MP0003283_abnormal_digestive_organ1.15239463
87MP0002095_abnormal_skin_pigmentation1.14327114
88MP0002736_abnormal_nociception_after1.13630693
89MP0003122_maternal_imprinting1.13540606
90MP0000955_abnormal_spinal_cord1.13442621
91MP0001485_abnormal_pinna_reflex1.12870184
92MP0002066_abnormal_motor_capabilities/c1.12859823
93MP0003011_delayed_dark_adaptation1.09909514
94MP0004142_abnormal_muscle_tone1.09860190
95MP0006036_abnormal_mitochondrial_physio1.09693255
96MP0004885_abnormal_endolymph1.08721492
97MP0003329_amyloid_beta_deposits1.07288983
98MP0005551_abnormal_eye_electrophysiolog1.07042466
99MP0002882_abnormal_neuron_morphology1.05370572
100MP0008961_abnormal_basal_metabolism1.04730947
101MP0004130_abnormal_muscle_cell1.04298019
102MP0005248_abnormal_Harderian_gland1.04276695
103MP0002876_abnormal_thyroid_physiology1.04122744
104MP0000750_abnormal_muscle_regeneration1.00028515
105MP0000371_diluted_coat_color0.99828727
106MP0003690_abnormal_glial_cell0.98726593
107MP0002971_abnormal_brown_adipose0.97644909
108MP0000013_abnormal_adipose_tissue0.96734232
109MP0005187_abnormal_penis_morphology0.92723648
110MP0002152_abnormal_brain_morphology0.92207466
111MP0002928_abnormal_bile_duct0.88735046
112MP0003123_paternal_imprinting0.85783378
113MP0003787_abnormal_imprinting0.85491036
114MP0003656_abnormal_erythrocyte_physiolo0.84973310
115MP0005220_abnormal_exocrine_pancreas0.84368448
116MP0001756_abnormal_urination0.84042697
117MP0005266_abnormal_metabolism0.83360792
118MP0005535_abnormal_body_temperature0.83105151
119MP0008775_abnormal_heart_ventricle0.82902861
120MP0002139_abnormal_hepatobiliary_system0.82252007
121MP0006138_congestive_heart_failure0.81891166
122MP0010386_abnormal_urinary_bladder0.81353837
123MP0001544_abnormal_cardiovascular_syste0.80682579
124MP0005385_cardiovascular_system_phenoty0.80682579
125MP0003119_abnormal_digestive_system0.79117830
126MP0002127_abnormal_cardiovascular_syste0.78016378
127MP0006276_abnormal_autonomic_nervous0.77595863
128MP0008789_abnormal_olfactory_epithelium0.77288483
129MP0003045_fibrosis0.76860244
130MP0003633_abnormal_nervous_system0.76276835
131MP0005367_renal/urinary_system_phenotyp0.75954857
132MP0000516_abnormal_urinary_system0.75954857
133MP0002638_abnormal_pupillary_reflex0.75352856
134MP0002332_abnormal_exercise_endurance0.75343503
135MP0010630_abnormal_cardiac_muscle0.75088315
136MP0006035_abnormal_mitochondrial_morpho0.74471260
137MP0003221_abnormal_cardiomyocyte_apopto0.73174167
138MP0002653_abnormal_ependyma_morphology0.73003136
139MP0001502_abnormal_circadian_rhythm0.71367282
140MP0010234_abnormal_vibrissa_follicle0.70607459
141MP0005377_hearing/vestibular/ear_phenot0.69646032
142MP0003878_abnormal_ear_physiology0.69646032
143MP0002069_abnormal_eating/drinking_beha0.69517150
144MP0008872_abnormal_physiological_respon0.68560153
145MP0002229_neurodegeneration0.68071598
146MP0001177_atelectasis0.65430655

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.45488885
2Focal motor seizures (HP:0011153)5.37394514
3Hypoglycemic coma (HP:0001325)5.34244353
4Hypoglycemic seizures (HP:0002173)5.32891241
5Exercise-induced myalgia (HP:0003738)4.88080820
6Myokymia (HP:0002411)4.54934067
7Exercise-induced muscle cramps (HP:0003710)4.44769276
8Ketoacidosis (HP:0001993)4.09957494
9Sudden death (HP:0001699)3.99674548
10Muscle hypertrophy of the lower extremities (HP:0008968)3.96594246
11Focal seizures (HP:0007359)3.96211174
12Calf muscle hypertrophy (HP:0008981)3.92493244
13Visual hallucinations (HP:0002367)3.85700050
14Hyperglycemia (HP:0003074)3.79017673
15Large for gestational age (HP:0001520)3.69353548
16Frequent falls (HP:0002359)3.58891894
17Bundle branch block (HP:0011710)3.54234467
18Ventricular fibrillation (HP:0001663)3.44146437
19Symptomatic seizures (HP:0011145)3.41108501
20Abnormality of the pancreatic islet cells (HP:0006476)3.32263488
21Abnormality of endocrine pancreas physiology (HP:0012093)3.32263488
22Muscle fiber inclusion bodies (HP:0100299)3.19389041
23Hypoplasia of the fovea (HP:0007750)3.14755652
24Aplasia/Hypoplasia of the fovea (HP:0008060)3.14755652
25Absence seizures (HP:0002121)3.10775314
26Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.09360004
27Prolonged QT interval (HP:0001657)3.04472822
28Abnormality of the calf musculature (HP:0001430)3.00556002
29Hemiparesis (HP:0001269)2.87857852
30Syncope (HP:0001279)2.86621165
31Poor eye contact (HP:0000817)2.85350465
32Myoglobinuria (HP:0002913)2.84610918
33Abnormal EKG (HP:0003115)2.82009778
34Dialeptic seizures (HP:0011146)2.80308448
35Atrial fibrillation (HP:0005110)2.80054906
36Insulin-resistant diabetes mellitus (HP:0000831)2.79752292
37Nemaline bodies (HP:0003798)2.79392196
38Generalized tonic-clonic seizures (HP:0002069)2.78339125
39Broad-based gait (HP:0002136)2.76428004
40Febrile seizures (HP:0002373)2.76377929
41Abnormality of the fovea (HP:0000493)2.75659423
42Subaortic stenosis (HP:0001682)2.74891471
43Abnormality of the left ventricular outflow tract (HP:0011103)2.74891471
44Epileptic encephalopathy (HP:0200134)2.70880756
45Primary atrial arrhythmia (HP:0001692)2.70480560
46Enlarged penis (HP:0000040)2.69233143
47Tongue fasciculations (HP:0001308)2.68475216
48Difficulty running (HP:0009046)2.68343076
49Late onset (HP:0003584)2.66514260
50Ankle clonus (HP:0011448)2.65898852
51Impaired social interactions (HP:0000735)2.64454273
52Abnormal social behavior (HP:0012433)2.64454273
53Hypothermia (HP:0002045)2.64419698
54Myopathic facies (HP:0002058)2.62648935
55Hypomagnesemia (HP:0002917)2.59894188
56Shoulder girdle muscle weakness (HP:0003547)2.59036765
57Muscle fiber splitting (HP:0003555)2.58340287
58Supraventricular tachycardia (HP:0004755)2.55638207
59EMG: myopathic abnormalities (HP:0003458)2.55587947
60Myotonia (HP:0002486)2.53264414
61Atonic seizures (HP:0010819)2.53220940
62Ventricular arrhythmia (HP:0004308)2.49846430
63Heart block (HP:0012722)2.49625768
64Supraventricular arrhythmia (HP:0005115)2.46384876
65Ketosis (HP:0001946)2.45675171
66Muscle fibrillation (HP:0010546)2.45189270
67Action tremor (HP:0002345)2.44245008
68Neoplasm of the adrenal cortex (HP:0100641)2.42797203
69Hyporeflexia of lower limbs (HP:0002600)2.39719500
70Increased circulating renin level (HP:0000848)2.37444300
71Pheochromocytoma (HP:0002666)2.37395225
72Resting tremor (HP:0002322)2.34087049
73Impaired vibration sensation in the lower limbs (HP:0002166)2.33479017
74Aplasia/Hypoplasia of the macula (HP:0008059)2.33244072
75Depression (HP:0000716)2.30809584
76Fetal akinesia sequence (HP:0001989)2.29796897
77Atrioventricular block (HP:0001678)2.28345347
78Abnormality of glycolipid metabolism (HP:0010969)2.27700498
79Abnormality of liposaccharide metabolism (HP:0010968)2.27700498
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.27700498
81Intestinal atresia (HP:0011100)2.26356755
82Dysmetric saccades (HP:0000641)2.24580924
83Abnormal atrioventricular conduction (HP:0005150)2.23613818
84Hamartoma of the eye (HP:0010568)2.22813252
85Anxiety (HP:0000739)2.20846063
86Type 1 muscle fiber predominance (HP:0003803)2.20249859
87Urinary urgency (HP:0000012)2.19311012
88Pelvic girdle muscle weakness (HP:0003749)2.17774744
89Vacuolated lymphocytes (HP:0001922)2.16785835
90Albinism (HP:0001022)2.16216937
91Neoplasm of the adrenal gland (HP:0100631)2.16047012
92Progressive cerebellar ataxia (HP:0002073)2.15858326
93Hepatic necrosis (HP:0002605)2.15841877
94Pancreatic islet-cell hyperplasia (HP:0004510)2.15374426
95Agitation (HP:0000713)2.14189498
96Dysdiadochokinesis (HP:0002075)2.14083750
97Urinary bladder sphincter dysfunction (HP:0002839)2.14038056
98Aplasia/Hypoplasia affecting the retina (HP:0008061)2.13665224
99Hyperkalemia (HP:0002153)2.13325545
100Distal arthrogryposis (HP:0005684)2.12037932
101Abnormality of the hip-girdle musculature (HP:0001445)2.11731238
102Abnormality of the musculature of the pelvis (HP:0001469)2.11731238
103Blue irides (HP:0000635)2.11643076
104Difficulty climbing stairs (HP:0003551)2.10820684
105Rimmed vacuoles (HP:0003805)2.10717652
106Prominent metopic ridge (HP:0005487)2.10511976
107Annular pancreas (HP:0001734)2.09327135
108EMG: neuropathic changes (HP:0003445)2.07999036
109Abnormality of the lower motor neuron (HP:0002366)2.07539907
110Ventricular tachycardia (HP:0004756)2.04562683
111Increased CSF protein (HP:0002922)2.04138376
112Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02693916
113Neuroendocrine neoplasm (HP:0100634)2.02586077
114Progressive macrocephaly (HP:0004481)2.02433419
115Abnormality of the metopic suture (HP:0005556)2.01140048
116Truncal ataxia (HP:0002078)2.01003824
117Hematochezia (HP:0002573)1.99359292
118Left ventricular hypertrophy (HP:0001712)1.97895641
119Gaze-evoked nystagmus (HP:0000640)1.93835473
120Lower limb amyotrophy (HP:0007210)1.92320043
121Truncus arteriosus (HP:0001660)1.90511833
122Unsteady gait (HP:0002317)1.88938131
123Athetosis (HP:0002305)1.84627586
124Papillary thyroid carcinoma (HP:0002895)1.84300579
125Palpitations (HP:0001962)1.83927133
126Abnormal drinking behavior (HP:0030082)1.81670171
127Polydipsia (HP:0001959)1.81670171
128Thyroid carcinoma (HP:0002890)1.81262982
129Hyperventilation (HP:0002883)1.80558809
130Decreased circulating renin level (HP:0003351)1.79884224
131Abnormality of magnesium homeostasis (HP:0004921)1.79255842
132Amblyopia (HP:0000646)1.78728278
133EEG with generalized epileptiform discharges (HP:0011198)1.77600184
134Muscle stiffness (HP:0003552)1.77556076
135Abnormality of the renal cortex (HP:0011035)1.77231895
136Methylmalonic acidemia (HP:0002912)1.77186141
137Epileptiform EEG discharges (HP:0011182)1.76588628
138Postural instability (HP:0002172)1.75501353
139Pointed chin (HP:0000307)1.73203807
140Renal cortical cysts (HP:0000803)1.71402887
141Neoplasm of the peripheral nervous system (HP:0100007)1.71360727
142Stereotypic behavior (HP:0000733)1.70872211
143Hypsarrhythmia (HP:0002521)1.70745776
144Generalized hypopigmentation (HP:0007513)1.70299612
145Testicular neoplasm (HP:0010788)1.70097239
146Hypokinesia (HP:0002375)1.69554075
147Impaired smooth pursuit (HP:0007772)1.69230624
148Megalencephaly (HP:0001355)1.69002669
149Postural tremor (HP:0002174)1.68514796
150Muscular hypotonia of the trunk (HP:0008936)1.68344925
151Conjunctival hamartoma (HP:0100780)1.68248704
152Hypokalemia (HP:0002900)1.66826974
153Iris hypopigmentation (HP:0007730)1.66754690
154Generalized hypopigmentation of hair (HP:0011358)1.65304053
155Proximal amyotrophy (HP:0007126)1.63986889
156Rhabdomyolysis (HP:0003201)1.62958222
157Central scotoma (HP:0000603)1.61958093
158Asymmetric septal hypertrophy (HP:0001670)1.60548522
159Abnormal pancreas size (HP:0012094)1.59854478
160Excessive salivation (HP:0003781)1.59660381
161Drooling (HP:0002307)1.59660381

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.76675729
2EPHA44.22653046
3NTRK33.49094695
4MAP3K93.20850308
5PRKD32.95066147
6NEK12.81927942
7OBSCN2.77101302
8FGFR22.74209448
9MARK12.69132610
10LMTK22.51383844
11PHKG12.47325990
12PHKG22.47325990
13MAP3K42.35338113
14DAPK22.19886855
15MAP4K22.16841648
16MINK12.05889350
17KSR11.90754888
18KSR21.85646603
19PNCK1.83567728
20TRIM281.70457891
21PDK41.69871744
22PDK31.69871744
23PINK11.61356708
24PAK61.60276096
25ACVR1B1.58020952
26TNIK1.57198134
27FGFR31.53804324
28BMPR1B1.53369420
29CAMKK11.52509413
30MAP3K21.47403002
31NTRK21.44489824
32MAP2K41.43901580
33ARAF1.36563287
34MAP2K71.35976132
35NTRK11.35708764
36TAOK11.29211768
37STK381.27194295
38STK31.21971188
39PRKAA21.19413428
40SGK21.16780912
41CAMKK21.13689012
42CDK51.11693909
43TTN1.09763191
44EIF2AK31.09745562
45NME11.08786413
46MAP2K61.08636788
47DAPK11.08163295
48HIPK21.06292930
49ADRBK21.06063048
50PKN21.04706521
51AKT31.03519018
52CSNK1G21.03486194
53RIPK11.02643072
54SGK2231.02379052
55SGK4941.02379052
56PRKCG1.01182625
57NLK1.00786852
58PLK20.98851378
59SGK30.98071760
60PDK20.94798713
61INSRR0.93449693
62DMPK0.90966233
63LATS20.90087319
64PRPF4B0.85048726
65ALK0.84532165
66CDC42BPA0.83238872
67PTK2B0.83107945
68GRK10.83002407
69GRK70.82926673
70STK240.81844808
71ERBB30.81726086
72TRPM70.81262615
73BRSK10.81140651
74CSNK1G10.79454836
75UHMK10.79306033
76PAK30.77746604
77MAPK130.76829121
78RIPK40.76618711
79IRAK10.75255461
80TYRO30.74473651
81YES10.73019099
82MOS0.70613706
83MAP3K120.70571811
84SGK10.69633796
85CAMK2A0.68744881
86GRK50.68717391
87EPHA30.67450849
88ZAK0.66726375
89STK390.66273512
90CAMK10.66064741
91STK110.64640986
92PASK0.63345682
93WNK40.61917269
94CSNK1G30.61490935
95PRKCH0.60980525
96SCYL20.60047859
97TSSK60.59080693
98CDK180.58993568
99CAMK2D0.58233887
100IRAK20.57808386
101BRAF0.57303552
102MAP2K10.56638077
103RAF10.55467803
104OXSR10.55109196
105CDK140.55085328
106BMPR20.55064686
107PRKG10.54700135
108CDK30.53571877
109SIK20.53357534
110CDK150.52817244
111CAMK2B0.51965449
112PRKAA10.51880580
113MAP3K70.51564419
114PLK30.50810029
115TAOK20.50318643
116RPS6KA30.50264529
117STK38L0.49845916
118PIK3CG0.48776595
119MAPK120.48611494
120CCNB10.48110512
121WNK30.47954659
122CAMK40.46862068
123PDPK10.46775570
124RET0.46597064
125WNK10.46373355
126CASK0.46175046
127TNK20.45682527
128MARK30.44797838
129MAPK100.44718461
130MAP3K10.44345918
131DYRK1A0.43881015
132CAMK2G0.43411149
133PRKACA0.43245252
134PKN10.43072205
135SIK30.43026801
136PRKCE0.42830766
137PDK10.42227580
138FER0.41574114
139CDK11A0.41367083
140CAMK1G0.40388099
141MUSK0.40148285
142STK40.39130713
143PDGFRA0.38881880
144NEK90.38367484
145RPS6KA20.37901370
146PRKACB0.34346369
147PRKCZ0.33711301
148MKNK20.33308928
149ROCK10.32450229

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.88464926
2Butanoate metabolism_Homo sapiens_hsa006502.99517547
3Olfactory transduction_Homo sapiens_hsa047402.92276548
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.80429123
5Synaptic vesicle cycle_Homo sapiens_hsa047212.74348639
6Nicotine addiction_Homo sapiens_hsa050332.59270645
7Long-term potentiation_Homo sapiens_hsa047202.48390940
8Circadian entrainment_Homo sapiens_hsa047132.41630197
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37354074
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.25959672
11Amphetamine addiction_Homo sapiens_hsa050312.25716369
12Cardiac muscle contraction_Homo sapiens_hsa042602.22176355
13GABAergic synapse_Homo sapiens_hsa047272.20248078
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18522100
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.16304656
16Morphine addiction_Homo sapiens_hsa050322.12163042
17Insulin secretion_Homo sapiens_hsa049112.11401293
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10890813
19Dopaminergic synapse_Homo sapiens_hsa047282.01806274
20Glutamatergic synapse_Homo sapiens_hsa047241.96163874
21Protein export_Homo sapiens_hsa030601.92868569
22Vitamin B6 metabolism_Homo sapiens_hsa007501.92646810
23Propanoate metabolism_Homo sapiens_hsa006401.85222804
24Gastric acid secretion_Homo sapiens_hsa049711.82533156
25Oxytocin signaling pathway_Homo sapiens_hsa049211.80782988
26Cholinergic synapse_Homo sapiens_hsa047251.80179667
27Dilated cardiomyopathy_Homo sapiens_hsa054141.76222431
28Salivary secretion_Homo sapiens_hsa049701.70609028
29Calcium signaling pathway_Homo sapiens_hsa040201.68924441
30Sulfur metabolism_Homo sapiens_hsa009201.66045213
31Fatty acid elongation_Homo sapiens_hsa000621.63193611
32Taste transduction_Homo sapiens_hsa047421.63150190
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61964869
34Renin secretion_Homo sapiens_hsa049241.59447551
35Cocaine addiction_Homo sapiens_hsa050301.53576450
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51721225
37GnRH signaling pathway_Homo sapiens_hsa049121.40788050
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39672651
39Tryptophan metabolism_Homo sapiens_hsa003801.37977562
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37762542
41Gap junction_Homo sapiens_hsa045401.35892584
42Type II diabetes mellitus_Homo sapiens_hsa049301.35815286
43Fatty acid degradation_Homo sapiens_hsa000711.35683317
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.35198911
45Long-term depression_Homo sapiens_hsa047301.34179411
46Oocyte meiosis_Homo sapiens_hsa041141.34052202
47Fatty acid metabolism_Homo sapiens_hsa012121.33342316
48beta-Alanine metabolism_Homo sapiens_hsa004101.32801435
49Collecting duct acid secretion_Homo sapiens_hsa049661.29863421
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29275093
51Ovarian steroidogenesis_Homo sapiens_hsa049131.26018638
52Serotonergic synapse_Homo sapiens_hsa047261.24636564
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19115800
54Circadian rhythm_Homo sapiens_hsa047101.12461884
55Lysosome_Homo sapiens_hsa041421.12162546
56cAMP signaling pathway_Homo sapiens_hsa040241.11422454
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09061598
58Glucagon signaling pathway_Homo sapiens_hsa049221.08545122
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08271361
60Melanogenesis_Homo sapiens_hsa049161.06856451
61Primary bile acid biosynthesis_Homo sapiens_hsa001201.06845018
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06528050
63Estrogen signaling pathway_Homo sapiens_hsa049151.06201006
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05538542
65Other glycan degradation_Homo sapiens_hsa005110.99470502
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97749921
67Type I diabetes mellitus_Homo sapiens_hsa049400.97508002
68Insulin signaling pathway_Homo sapiens_hsa049100.97027402
69Glioma_Homo sapiens_hsa052140.95822973
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.95009521
71Folate biosynthesis_Homo sapiens_hsa007900.93952313
72Peroxisome_Homo sapiens_hsa041460.91989807
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90326657
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89047612
75Parkinsons disease_Homo sapiens_hsa050120.88993128
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87103588
77ErbB signaling pathway_Homo sapiens_hsa040120.86382828
78Pancreatic secretion_Homo sapiens_hsa049720.85735326
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82995928
80* mTOR signaling pathway_Homo sapiens_hsa041500.82282724
81Tight junction_Homo sapiens_hsa045300.81859899
82ABC transporters_Homo sapiens_hsa020100.81059184
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78314846
84Alzheimers disease_Homo sapiens_hsa050100.77789746
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77458202
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76214786
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75426455
88Vibrio cholerae infection_Homo sapiens_hsa051100.73719925
89Axon guidance_Homo sapiens_hsa043600.72319252
90Endometrial cancer_Homo sapiens_hsa052130.72304760
91Dorso-ventral axis formation_Homo sapiens_hsa043200.71398278
92Sphingolipid metabolism_Homo sapiens_hsa006000.70973044
93Mineral absorption_Homo sapiens_hsa049780.65264710
94Thyroid hormone synthesis_Homo sapiens_hsa049180.64996238
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63993292
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63450062
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63432355
98Regulation of autophagy_Homo sapiens_hsa041400.63168490
99MAPK signaling pathway_Homo sapiens_hsa040100.62123884
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.59599998
101Steroid biosynthesis_Homo sapiens_hsa001000.59435465
102Phototransduction_Homo sapiens_hsa047440.59012478
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.58762617
104Oxidative phosphorylation_Homo sapiens_hsa001900.58427858
105Fructose and mannose metabolism_Homo sapiens_hsa000510.57543003
106Huntingtons disease_Homo sapiens_hsa050160.56972461
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56728287
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56076677
109Inositol phosphate metabolism_Homo sapiens_hsa005620.55329087
110Nitrogen metabolism_Homo sapiens_hsa009100.54753584
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.54691641
112Starch and sucrose metabolism_Homo sapiens_hsa005000.54653598
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54486428
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54210283
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.53062272
116Non-small cell lung cancer_Homo sapiens_hsa052230.51561285
117Choline metabolism in cancer_Homo sapiens_hsa052310.51342266
118AMPK signaling pathway_Homo sapiens_hsa041520.51333806
119Wnt signaling pathway_Homo sapiens_hsa043100.50693078
120VEGF signaling pathway_Homo sapiens_hsa043700.50123191
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50062981
122Bile secretion_Homo sapiens_hsa049760.49945618
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49892400
124Hippo signaling pathway_Homo sapiens_hsa043900.49782030
125Alcoholism_Homo sapiens_hsa050340.49656433
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49456287
127Carbon metabolism_Homo sapiens_hsa012000.49157747
128Renal cell carcinoma_Homo sapiens_hsa052110.47161180
129Ether lipid metabolism_Homo sapiens_hsa005650.45438330
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44876634
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44705544
132Insulin resistance_Homo sapiens_hsa049310.44535210
133FoxO signaling pathway_Homo sapiens_hsa040680.43678421
134Selenocompound metabolism_Homo sapiens_hsa004500.43212121
135Rheumatoid arthritis_Homo sapiens_hsa053230.43047353
136Rap1 signaling pathway_Homo sapiens_hsa040150.42569528
137PPAR signaling pathway_Homo sapiens_hsa033200.42542670
138Galactose metabolism_Homo sapiens_hsa000520.42353176
139HIF-1 signaling pathway_Homo sapiens_hsa040660.38645426
140Hedgehog signaling pathway_Homo sapiens_hsa043400.37621205
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.37376902
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35673262

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