RRAGC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)4.60897836
2positive regulation by symbiont of host defense response (GO:0052509)4.54378990
3modulation by symbiont of host defense response (GO:0052031)4.54378990
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.54378990
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.54378990
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.54378990
7modulation by symbiont of host immune response (GO:0052553)4.54378990
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.30809965
9regulation of cholesterol storage (GO:0010885)4.04390635
10regulation of vitamin D biosynthetic process (GO:0060556)4.01508636
11protein localization to endosome (GO:0036010)3.98712028
12oligosaccharide catabolic process (GO:0009313)3.96630526
13regulation of interferon-beta biosynthetic process (GO:0045357)3.90106824
14virion attachment to host cell (GO:0019062)3.74546628
15adhesion of symbiont to host cell (GO:0044650)3.74546628
16negative regulation of interleukin-12 production (GO:0032695)3.68564539
17positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.58215925
18regulation of T-helper 1 cell differentiation (GO:0045625)3.56348283
19regulation of early endosome to late endosome transport (GO:2000641)3.53634699
20cellular response to type I interferon (GO:0071357)3.51285269
21type I interferon signaling pathway (GO:0060337)3.51285269
22response to type I interferon (GO:0034340)3.46840598
23apoptotic cell clearance (GO:0043277)3.44152205
24positive regulation of interferon-alpha production (GO:0032727)3.36214529
25macrophage activation involved in immune response (GO:0002281)3.34164171
26growth hormone receptor signaling pathway (GO:0060396)3.33646324
27negative regulation of nitric oxide biosynthetic process (GO:0045019)3.29738846
28regulation of sequestering of triglyceride (GO:0010889)3.26475527
29regulation of chronic inflammatory response (GO:0002676)3.21934945
30sphingosine metabolic process (GO:0006670)3.21633475
31regulation of interferon-alpha production (GO:0032647)3.17989354
32negative regulation of lipid storage (GO:0010888)3.13932867
33positive regulation of p38MAPK cascade (GO:1900745)3.13166137
34negative regulation of mast cell activation (GO:0033004)3.12762323
35regulation of mononuclear cell migration (GO:0071675)3.10211128
36cell adhesion mediated by integrin (GO:0033627)3.10034056
37neutrophil activation involved in immune response (GO:0002283)3.09444386
38regulation of chemokine biosynthetic process (GO:0045073)3.07510110
39positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.07498075
40interleukin-6-mediated signaling pathway (GO:0070102)2.99972188
41regulation of membrane protein ectodomain proteolysis (GO:0051043)2.99902739
42regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.99231749
43adhesion of symbiont to host (GO:0044406)2.97767310
44regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.97015993
45regulation of vitamin metabolic process (GO:0030656)2.95340186
46branching involved in labyrinthine layer morphogenesis (GO:0060670)2.89795149
47cellular response to interferon-alpha (GO:0035457)2.86908055
48cellular response to thyroid hormone stimulus (GO:0097067)2.84194119
49diol metabolic process (GO:0034311)2.82396173
50skin morphogenesis (GO:0043589)2.80245185
51cellular response to growth hormone stimulus (GO:0071378)2.80194180
52amino sugar catabolic process (GO:0046348)2.80182169
53negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.79932328
54sphingoid metabolic process (GO:0046519)2.79265753
55regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.78908585
56negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.78462102
57regulation of cytokine secretion involved in immune response (GO:0002739)2.76759284
58JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.75573659
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74120244
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74120244
61regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.71192481
62immunoglobulin mediated immune response (GO:0016064)2.70936372
63T-helper 1 type immune response (GO:0042088)2.70412756
64glycosphingolipid catabolic process (GO:0046479)2.68995715
65positive regulation of lipid storage (GO:0010884)2.68825112
66regulation of interleukin-8 biosynthetic process (GO:0045414)2.68199773
67ovulation from ovarian follicle (GO:0001542)2.68020257
68response to host (GO:0075136)2.63531155
69response to host defenses (GO:0052200)2.63531155
70response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.63531155
71positive regulation of heat generation (GO:0031652)2.63447840
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.62509899
73response to host immune response (GO:0052572)2.62509899
74positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.62126685
75N-acetylneuraminate metabolic process (GO:0006054)2.61331055
76regulation of nitric oxide biosynthetic process (GO:0045428)2.61326627
77regulation of podosome assembly (GO:0071801)2.61128284
78positive regulation of calcium ion import (GO:0090280)2.59762949
79regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.59568121
80regulation of clathrin-mediated endocytosis (GO:2000369)2.59524078
81positive regulation of NF-kappaB import into nucleus (GO:0042346)2.59346214
82positive regulation of interleukin-6 production (GO:0032755)2.58640332
83regulation of macrophage chemotaxis (GO:0010758)2.57156156
84positive regulation of toll-like receptor signaling pathway (GO:0034123)2.56625269
85natural killer cell mediated immunity (GO:0002228)2.54900873
86natural killer cell mediated cytotoxicity (GO:0042267)2.54900873
87defense response to protozoan (GO:0042832)2.54684625
88plasma lipoprotein particle clearance (GO:0034381)2.53649940
89positive regulation of natural killer cell activation (GO:0032816)2.53564337
90positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.52953051
91positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.52567466
92detection of molecule of bacterial origin (GO:0032490)2.52344155
93regulation of interleukin-12 biosynthetic process (GO:0045075)2.51998775
94keratan sulfate catabolic process (GO:0042340)2.51305444
95response to protozoan (GO:0001562)2.51072703
96regulation of fever generation (GO:0031620)2.50207109
97response to lipoprotein particle (GO:0055094)2.49739201
98lipoprotein transport (GO:0042953)2.49601512
99stress fiber assembly (GO:0043149)2.48908787
100negative regulation of protein localization to plasma membrane (GO:1903077)2.48890210
101regulation of interleukin-12 production (GO:0032655)2.48278646
102decidualization (GO:0046697)2.48045080
103L-alpha-amino acid transmembrane transport (GO:1902475)2.48000430
104substrate-dependent cell migration (GO:0006929)2.47636540
105interferon-gamma-mediated signaling pathway (GO:0060333)2.47122998
106antigen processing and presentation of endogenous antigen (GO:0019883)2.46897902
107positive regulation of nitric oxide biosynthetic process (GO:0045429)2.46458137
108negative regulation of fatty acid transport (GO:2000192)2.46211097
109membrane lipid catabolic process (GO:0046466)2.45423387
110positive regulation of chemokine production (GO:0032722)2.44209173
111regulation of fatty acid beta-oxidation (GO:0031998)2.43976950
112regulation of macrophage derived foam cell differentiation (GO:0010743)2.43570929
113regulation of macrophage cytokine production (GO:0010935)2.43413411
114positive regulation of histone deacetylation (GO:0031065)2.42129619
115lipopolysaccharide-mediated signaling pathway (GO:0031663)2.42050095
116sphingolipid catabolic process (GO:0030149)2.40056316
117cellular response to molecule of bacterial origin (GO:0071219)2.39970346
118cellular response to lipopolysaccharide (GO:0071222)2.39240273
119ceramide catabolic process (GO:0046514)2.39073764
120positive regulation of macrophage cytokine production (GO:0060907)2.38756545
121response to peptidoglycan (GO:0032494)2.37726302
122regulation of dendritic cell antigen processing and presentation (GO:0002604)2.37707789
123positive regulation of cellular amide metabolic process (GO:0034250)2.36991053
124positive regulation of type 2 immune response (GO:0002830)2.36007557
125negative regulation of monooxygenase activity (GO:0032769)2.35594583
126regulation of T cell tolerance induction (GO:0002664)2.35487043
127positive regulation of fatty acid beta-oxidation (GO:0032000)2.35258771
128cortical actin cytoskeleton organization (GO:0030866)2.34699583
129glycolipid catabolic process (GO:0019377)2.33992947
130negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.33688005
131JAK-STAT cascade (GO:0007259)2.32823632
132regulation of lipid storage (GO:0010883)2.31995253
133macroautophagy (GO:0016236)2.31574913
134eosinophil chemotaxis (GO:0048245)2.31525539
135positive regulation of interleukin-12 production (GO:0032735)2.31489957
136regulation of inflammatory response to antigenic stimulus (GO:0002861)2.31401855
137regulation of type 2 immune response (GO:0002828)2.30958864
138regulation of interleukin-6 production (GO:0032675)2.30652248
139myeloid dendritic cell differentiation (GO:0043011)2.30445087
140respiratory burst (GO:0045730)2.30111461
141response to laminar fluid shear stress (GO:0034616)2.29814398
142platelet-derived growth factor receptor signaling pathway (GO:0048008)2.29137936
143positive regulation vascular endothelial growth factor production (GO:0010575)2.29007775
144positive regulation of leukocyte degranulation (GO:0043302)2.28445124
145intracellular lipid transport (GO:0032365)2.27891421
146cytoplasmic mRNA processing body assembly (GO:0033962)2.27737323
147protein carboxylation (GO:0018214)2.25299305
148peptidyl-glutamic acid carboxylation (GO:0017187)2.25299305
149positive regulation of chemokine biosynthetic process (GO:0045080)2.24996798
150positive regulation of lipid catabolic process (GO:0050996)2.24797978
151positive regulation of lamellipodium assembly (GO:0010592)2.23591526
152production of molecular mediator involved in inflammatory response (GO:0002532)2.23414560
153pentose-phosphate shunt (GO:0006098)2.22703634
154pinocytosis (GO:0006907)2.19930941
155positive regulation of cellular response to insulin stimulus (GO:1900078)2.18516582
156positive regulation of interferon-beta production (GO:0032728)2.17450508
157endodermal cell differentiation (GO:0035987)2.16743125
158fibroblast migration (GO:0010761)2.14078193
159activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.13751624
160positive regulation of natural killer cell differentiation (GO:0032825)2.13706677
161cellular response to arsenic-containing substance (GO:0071243)2.13481210
162regulation of integrin activation (GO:0033623)2.13179293
163response to muramyl dipeptide (GO:0032495)2.11791730
164positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.10006561
165lipid storage (GO:0019915)2.09614782
166response to interferon-alpha (GO:0035455)2.09522866
167granulocyte activation (GO:0036230)2.08659004
168cellular response to vitamin (GO:0071295)2.07334033
169regulation of integrin-mediated signaling pathway (GO:2001044)2.07290077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.92620498
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.53529053
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.49962298
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.02226061
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.97138971
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.88850354
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84435870
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79494394
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.72365308
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.46930223
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.44747605
12CLOCK_20551151_ChIP-Seq_293T_Human2.43430028
13* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.35245779
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.31341327
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.29914441
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13125974
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10929714
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.10331989
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07016282
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.06168227
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05332698
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.00289425
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99995997
24PPARA_22158963_ChIP-Seq_LIVER_Mouse1.99980267
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.95542474
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.94063762
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.91375186
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.84989824
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83034973
30BRD4_25478319_ChIP-Seq_HGPS_Human1.74043978
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.72722248
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70982311
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63736341
34* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57907638
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56370496
36TCF7_22412390_ChIP-Seq_EML_Mouse1.54745302
37* ELK3_25401928_ChIP-Seq_HUVEC_Human1.53198425
38* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49979569
39ATF3_27146783_Chip-Seq_COLON_Human1.49690772
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49471430
41* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48653658
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.48373183
43* KDM2B_26808549_Chip-Seq_DND41_Human1.46534134
44* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45160566
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44774088
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44492646
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43583742
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40944221
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.39941216
50* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38271104
51TP53_16413492_ChIP-PET_HCT116_Human1.37865247
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37460978
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.37247009
54* VDR_24763502_ChIP-Seq_THP-1_Human1.36994536
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35607045
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33773294
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33736353
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33374395
59SPI1_23127762_ChIP-Seq_K562_Human1.32629988
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32239000
61VDR_21846776_ChIP-Seq_THP-1_Human1.31126942
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30671382
63CJUN_26792858_Chip-Seq_BT549_Human1.30024991
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30009806
65TP63_23658742_ChIP-Seq_EP156T_Human1.29168789
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28810151
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27172329
68PU_27001747_Chip-Seq_BMDM_Mouse1.25920620
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.24367461
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24334712
71* VDR_24787735_ChIP-Seq_THP-1_Human1.23138492
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22874615
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22804667
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22218747
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22210061
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22147821
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22123651
78GATA1_22025678_ChIP-Seq_K562_Human1.21753385
79* MAF_26560356_Chip-Seq_TH1_Human1.21726683
80FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.21277862
81RACK7_27058665_Chip-Seq_MCF-7_Human1.21246202
82MYC_22102868_ChIP-Seq_BL_Human1.21131260
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.21110160
84* GATA1_19941826_ChIP-Seq_K562_Human1.19751947
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18060727
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16783739
87TP53_18474530_ChIP-ChIP_U2OS_Human1.16751395
88CDX2_22108803_ChIP-Seq_LS180_Human1.16014640
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15558826
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13510733
91* TFEB_21752829_ChIP-Seq_HELA_Human1.13042876
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12853299
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12056895
94GATA3_27048872_Chip-Seq_THYMUS_Human1.11602695
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11422638
96RUNX1_22412390_ChIP-Seq_EML_Mouse1.10666666
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10268556
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08495469
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.08348103
100KDM2B_26808549_Chip-Seq_JURKAT_Human1.08003943
101SOX2_20726797_ChIP-Seq_SW620_Human1.06879111
102ZNF263_19887448_ChIP-Seq_K562_Human1.06520611
103* KDM2B_26808549_Chip-Seq_K562_Human1.05951097
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05776251
105NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05776251
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05272071
107MYB_26560356_Chip-Seq_TH2_Human1.04500523
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03779232
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03744148
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03547080
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.02315475
112RUNX_20019798_ChIP-Seq_JUKART_Human1.02089990
113* UTX_26944678_Chip-Seq_JUKART_Human1.01312046
114FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00437105
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00239942
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99172717
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98568600
118GATA6_25053715_ChIP-Seq_YYC3_Human0.97643932
119SMRT_27268052_Chip-Seq_Bcells_Human0.97508554
120CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97402881
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96856967
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96856967
123GATA3_26560356_Chip-Seq_TH2_Human0.95867052
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.95820879
125* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92398903
126EP300_21415370_ChIP-Seq_HL-1_Mouse0.91564562
127SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91515885
128* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90773366
129NANOG_18555785_Chip-Seq_ESCs_Mouse0.89326807
130CMYC_18555785_Chip-Seq_ESCs_Mouse0.87918475
131SPI1_23547873_ChIP-Seq_NB4_Human0.87314842
132SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87128059
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85853588
134ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85330853
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85213873
136AHR_22903824_ChIP-Seq_MCF-7_Human0.84009254
137VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83821431
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80358670
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.80224401
140PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.79718207
141NFE2_27457419_Chip-Seq_LIVER_Mouse0.79168289
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.79028567
143P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78923090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.82310592
2MP0003705_abnormal_hypodermis_morpholog3.70091587
3MP0003303_peritoneal_inflammation3.24315565
4MP0008438_abnormal_cutaneous_collagen3.13602891
5MP0009840_abnormal_foam_cell2.92338720
6MP0003950_abnormal_plasma_membrane2.84663559
7MP0003300_gastrointestinal_ulcer2.71607627
8MP0006054_spinal_hemorrhage2.57691631
9MP0003436_decreased_susceptibility_to2.48532765
10MP0002877_abnormal_melanocyte_morpholog2.44635638
11MP0004185_abnormal_adipocyte_glucose2.42131122
12MP0003191_abnormal_cellular_cholesterol2.23343759
13MP0004510_myositis2.05601974
14MP0006082_CNS_inflammation2.03261694
15MP0003566_abnormal_cell_adhesion2.03206704
16MP0003172_abnormal_lysosome_physiology1.97418829
17MP0005076_abnormal_cell_differentiation1.89412681
18MP0001542_abnormal_bone_strength1.82325795
19MP0001835_abnormal_antigen_presentation1.79025645
20MP0002419_abnormal_innate_immunity1.74233775
21MP0004130_abnormal_muscle_cell1.72700044
22MP0005275_abnormal_skin_tensile1.70031503
23MP0001533_abnormal_skeleton_physiology1.67347137
24MP0008004_abnormal_stomach_pH1.62807057
25MP0010307_abnormal_tumor_latency1.61581879
26MP0003448_altered_tumor_morphology1.60867341
27MP0010352_gastrointestinal_tract_polyps1.60631967
28MP0003091_abnormal_cell_migration1.58582240
29MP0005666_abnormal_adipose_tissue1.56639578
30MP0005257_abnormal_intraocular_pressure1.55895357
31MP0005000_abnormal_immune_tolerance1.54561294
32MP0005464_abnormal_platelet_physiology1.53536794
33MP0010234_abnormal_vibrissa_follicle1.53031483
34MP0002138_abnormal_hepatobiliary_system1.52987880
35MP0004947_skin_inflammation1.47005576
36MP0000604_amyloidosis1.46436788
37MP0003453_abnormal_keratinocyte_physiol1.44619478
38MP0002998_abnormal_bone_remodeling1.42158943
39MP0009785_altered_susceptibility_to1.41228475
40MP0000569_abnormal_digit_pigmentation1.38900336
41MP0005023_abnormal_wound_healing1.35259226
42MP0005387_immune_system_phenotype1.34573735
43MP0001790_abnormal_immune_system1.34573735
44MP0003186_abnormal_redox_activity1.33577884
45MP0003075_altered_response_to1.32925140
46MP0000343_altered_response_to1.32092481
47MP0002139_abnormal_hepatobiliary_system1.31873356
48MP0001958_emphysema1.30686205
49MP0005671_abnormal_response_to1.28559126
50MP0003724_increased_susceptibility_to1.27343738
51MP0005670_abnormal_white_adipose1.27300143
52MP0000858_altered_metastatic_potential1.26681139
53MP0002254_reproductive_system_inflammat1.25554958
54MP0002452_abnormal_antigen_presenting1.25468940
55MP0002971_abnormal_brown_adipose1.23798213
56MP0000733_abnormal_muscle_development1.23308856
57MP0005025_abnormal_response_to1.21701879
58MP0002332_abnormal_exercise_endurance1.21115011
59MP0003690_abnormal_glial_cell1.20967176
60MP0005375_adipose_tissue_phenotype1.19940357
61MP0002006_tumorigenesis1.17625657
62MP0005451_abnormal_body_composition1.17415974
63MP0000685_abnormal_immune_system1.17043157
64MP0004883_abnormal_blood_vessel1.16296273
65MP0005360_urolithiasis1.16295091
66MP0000609_abnormal_liver_physiology1.16058644
67MP0001853_heart_inflammation1.15427888
68MP0000015_abnormal_ear_pigmentation1.13114505
69MP0010329_abnormal_lipoprotein_level1.12984554
70MP0005595_abnormal_vascular_smooth1.12091049
71MP0005167_abnormal_blood-brain_barrier1.10842276
72MP0001845_abnormal_inflammatory_respons1.10686890
73MP0010386_abnormal_urinary_bladder1.09887301
74MP0009278_abnormal_bone_marrow1.09109645
75MP0002148_abnormal_hypersensitivity_rea1.09003731
76MP0002168_other_aberrant_phenotype1.07719646
77MP0002723_abnormal_immune_serum1.06222218
78MP0009115_abnormal_fat_cell1.06081336
79MP0000371_diluted_coat_color1.04740036
80MP0005310_abnormal_salivary_gland1.04724122
81MP0002166_altered_tumor_susceptibility1.03675687
82MP0009764_decreased_sensitivity_to1.03353523
83MP0008469_abnormal_protein_level1.01790246
84MP0003195_calcinosis1.01338230
85MP0003806_abnormal_nucleotide_metabolis1.00624828
86MP0002405_respiratory_system_inflammati1.00585615
87MP0005397_hematopoietic_system_phenotyp0.98874512
88MP0001545_abnormal_hematopoietic_system0.98874512
89MP0001800_abnormal_humoral_immune0.98446553
90MP0005164_abnormal_response_to0.97262447
91MP0002876_abnormal_thyroid_physiology0.96145663
92MP0005390_skeleton_phenotype0.93853887
93MP0001819_abnormal_immune_cell0.92220471
94MP0001216_abnormal_epidermal_layer0.92018382
95MP0001881_abnormal_mammary_gland0.91918517
96MP0001851_eye_inflammation0.91103034
97MP0001849_ear_inflammation0.90684013
98MP0002420_abnormal_adaptive_immunity0.90523611
99MP0005166_decreased_susceptibility_to0.89196355
100MP0002118_abnormal_lipid_homeostasis0.89176117
101MP0010155_abnormal_intestine_physiology0.89010998
102MP0002295_abnormal_pulmonary_circulatio0.88732051
103MP0010368_abnormal_lymphatic_system0.88395891
104MP0005174_abnormal_tail_pigmentation0.88034878
105MP0008260_abnormal_autophagy0.87884247
106MP0001915_intracranial_hemorrhage0.86799789
107MP0001243_abnormal_dermal_layer0.86442369
108MP0003795_abnormal_bone_structure0.85727182
109MP0003045_fibrosis0.85426201
110MP0005408_hypopigmentation0.85388641
111MP0009333_abnormal_splenocyte_physiolog0.84911428
112MP0003279_aneurysm0.84275348
113MP0005165_increased_susceptibility_to0.83958908
114MP0003656_abnormal_erythrocyte_physiolo0.83770136
115MP0005334_abnormal_fat_pad0.83395386
116MP0003828_pulmonary_edema0.81758456
117MP0009763_increased_sensitivity_to0.81032010
118MP0003252_abnormal_bile_duct0.80168685
119MP0002933_joint_inflammation0.79365553
120MP0000003_abnormal_adipose_tissue0.78918284
121MP0002060_abnormal_skin_morphology0.78769691
122MP0005379_endocrine/exocrine_gland_phen0.78499904
123MP0000767_abnormal_smooth_muscle0.78270906
124MP0003183_abnormal_peptide_metabolism0.77963906
125MP0004272_abnormal_basement_membrane0.74336849
126MP0005647_abnormal_sex_gland0.73471246
127MP0002796_impaired_skin_barrier0.72794678
128MP0004043_abnormal_pH_regulation0.71928586
129MP0002896_abnormal_bone_mineralization0.69673624
130MP0010678_abnormal_skin_adnexa0.69598283
131MP0000716_abnormal_immune_system0.67692883

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)4.39328862
2Nuclear cataract (HP:0100018)4.15107743
3Myocardial infarction (HP:0001658)3.73977350
4Dysostosis multiplex (HP:0000943)3.73436899
5Eczematoid dermatitis (HP:0000976)3.63176432
6Vacuolated lymphocytes (HP:0001922)3.57643278
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.51518443
8Albinism (HP:0001022)3.41684822
9Recurrent gram-negative bacterial infections (HP:0005420)3.41403028
10Peritonitis (HP:0002586)3.34553277
11Urinary glycosaminoglycan excretion (HP:0003541)3.28340721
12Mucopolysacchariduria (HP:0008155)3.28340721
13Protrusio acetabuli (HP:0003179)3.25974506
14Recurrent abscess formation (HP:0002722)3.24600427
15Mutism (HP:0002300)3.22908403
16Tetraparesis (HP:0002273)3.20823011
17Abnormality of polysaccharide metabolism (HP:0011012)3.16190557
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.16190557
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.16190557
20Autoimmune thrombocytopenia (HP:0001973)3.10018746
21Cerebral aneurysm (HP:0004944)3.06966658
22Recurrent bacterial skin infections (HP:0005406)3.05417940
23Orchitis (HP:0100796)3.04539006
24Cervical subluxation (HP:0003308)3.02878986
25Axonal loss (HP:0003447)3.01515457
26Optic neuritis (HP:0100653)2.98686118
27Retrobulbar optic neuritis (HP:0100654)2.98686118
28Premature rupture of membranes (HP:0001788)2.94849761
29Abnormality of liposaccharide metabolism (HP:0010968)2.92052865
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.92052865
31Abnormality of glycolipid metabolism (HP:0010969)2.92052865
32Disinhibition (HP:0000734)2.91688825
33Abnormality of macrophages (HP:0004311)2.90446173
34Systemic lupus erythematosus (HP:0002725)2.88140292
35Severe visual impairment (HP:0001141)2.78966675
36Progressive neurologic deterioration (HP:0002344)2.78131639
37Follicular hyperkeratosis (HP:0007502)2.68817365
38Deep venous thrombosis (HP:0002625)2.66833165
39Hematochezia (HP:0002573)2.56473870
40Stomatitis (HP:0010280)2.55978111
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.55651437
42Osteolytic defects of the hand bones (HP:0009699)2.52990008
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.52990008
44Global brain atrophy (HP:0002283)2.51826973
45Parakeratosis (HP:0001036)2.51159246
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.49101965
47Pulmonary infiltrates (HP:0002113)2.44037202
48Loss of speech (HP:0002371)2.43284876
49Neurofibrillary tangles (HP:0002185)2.43039109
50Mitral valve prolapse (HP:0001634)2.41514469
51Aortic dissection (HP:0002647)2.39129682
52Myositis (HP:0100614)2.38100087
53Ankle contracture (HP:0006466)2.35334403
54Male infertility (HP:0003251)2.32888637
55Xanthomatosis (HP:0000991)2.31980790
56Aortic aneurysm (HP:0004942)2.30552147
57Asymmetric septal hypertrophy (HP:0001670)2.29185575
58Vascular tortuosity (HP:0004948)2.27164836
59Spondylolisthesis (HP:0003302)2.26407762
60Complement deficiency (HP:0004431)2.25051088
61Hypokinesia (HP:0002375)2.24914259
62Arterial tortuosity (HP:0005116)2.23134024
63Abnormality of proline metabolism (HP:0010907)2.21610946
64Hydroxyprolinuria (HP:0003080)2.21610946
65Dilatation of the ascending aorta (HP:0005111)2.21219744
66Increased CSF protein (HP:0002922)2.20896012
67Striae distensae (HP:0001065)2.19928578
68Thick nail (HP:0001805)2.18547723
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14285760
70Genu recurvatum (HP:0002816)2.13970935
71Diminished motivation (HP:0000745)2.12834789
72Shallow orbits (HP:0000586)2.11088808
73Aneurysm (HP:0002617)2.10088590
74Keratoconjunctivitis sicca (HP:0001097)2.09895080
75Cerebral inclusion bodies (HP:0100314)2.09441434
76Petechiae (HP:0000967)2.09102399
77Sensorimotor neuropathy (HP:0007141)2.07169825
78Abnormality of complement system (HP:0005339)2.07062817
79Tongue fasciculations (HP:0001308)2.06949563
80Upper limb amyotrophy (HP:0009129)2.06434230
81Distal upper limb amyotrophy (HP:0007149)2.06434230
82Cortical dysplasia (HP:0002539)2.06049017
83Keratoconjunctivitis (HP:0001096)2.04806368
84Cardiomegaly (HP:0001640)2.04372280
85Polycythemia (HP:0001901)2.01279121
86Hand muscle atrophy (HP:0009130)2.01232925
87Hemoptysis (HP:0002105)2.01217270
88Muscle fibrillation (HP:0010546)2.00836326
89Zonular cataract (HP:0010920)1.99768912
90Apathy (HP:0000741)1.99595942
91Inappropriate behavior (HP:0000719)1.99326156
92Erythroderma (HP:0001019)1.97714882
93Autoimmune hemolytic anemia (HP:0001890)1.96443684
94Vertebral compression fractures (HP:0002953)1.95849152
95Interstitial pulmonary disease (HP:0006530)1.95817322
96Mitral stenosis (HP:0001718)1.95794487
97Skin nodule (HP:0200036)1.95620330
98Congenital ichthyosiform erythroderma (HP:0007431)1.95209821
99Subacute progressive viral hepatitis (HP:0006572)1.93961963
100Enlarged penis (HP:0000040)1.93708273
101Abnormality of T cell number (HP:0011839)1.93601294
102Abnormality of the lumbar spine (HP:0100712)1.93157302
103Malnutrition (HP:0004395)1.93067146
104Gastrointestinal infarctions (HP:0005244)1.92446160
105Long toe (HP:0010511)1.92029796
106Recurrent skin infections (HP:0001581)1.91691740
107Gingivitis (HP:0000230)1.89767897
108Exocrine pancreatic insufficiency (HP:0001738)1.89172134
109Abnormality of the pericardium (HP:0001697)1.88564859
110Vasculitis (HP:0002633)1.88199999
111Nephritis (HP:0000123)1.87881021
112Ovoid vertebral bodies (HP:0003300)1.87175583
113Corneal dystrophy (HP:0001131)1.86962249
114Peripheral demyelination (HP:0011096)1.86103787
115Glomerulonephritis (HP:0000099)1.85513896
116Esophageal varix (HP:0002040)1.84625476
117Hypercortisolism (HP:0001578)1.83213980
118Abnormality of B cell number (HP:0010975)1.81749392
119Cellulitis (HP:0100658)1.81547185
120Short nail (HP:0001799)1.80440951
121Alopecia of scalp (HP:0002293)1.80166938
122Nausea (HP:0002018)1.79426072
123Camptodactyly of toe (HP:0001836)1.78900552
124Thoracic kyphosis (HP:0002942)1.78495542
125Abnormality of the common coagulation pathway (HP:0010990)1.78243033
126Multiple lipomas (HP:0001012)1.77364177
127T lymphocytopenia (HP:0005403)1.76734718
128Thin bony cortex (HP:0002753)1.76650250
129Prolonged neonatal jaundice (HP:0006579)1.76515239
130Metaphyseal irregularity (HP:0003025)1.75707946
131Achilles tendon contracture (HP:0001771)1.75044566
132Abnormality of the Achilles tendon (HP:0005109)1.74699252
133Hemorrhage of the eye (HP:0011885)1.74357513
134Eosinophilia (HP:0001880)1.73721631
135Pustule (HP:0200039)1.73374270
136Hypoplasia of the fovea (HP:0007750)1.72690552
137Aplasia/Hypoplasia of the fovea (HP:0008060)1.72690552
138Mediastinal lymphadenopathy (HP:0100721)1.72474044
139Conjunctival telangiectasia (HP:0000524)1.72255947
140Recurrent fungal infections (HP:0002841)1.72041421
141Hypercholesterolemia (HP:0003124)1.71756156
142Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71590179
143Protuberant abdomen (HP:0001538)1.70528979
144Polygenic inheritance (HP:0010982)1.70124821
145Bone cyst (HP:0012062)1.69888740
146Mucosal telangiectasiae (HP:0100579)1.68650351
147Abnormality of glutamine family amino acid metabolism (HP:0010902)1.68090594
148Amyloidosis (HP:0011034)1.67853281
149Progressive visual loss (HP:0000529)1.67656242
150Thyroiditis (HP:0100646)1.66021967
151Coarse hair (HP:0002208)1.65454028
152Gangrene (HP:0100758)1.65067383
153Thoracolumbar scoliosis (HP:0002944)1.64979634
154Exostoses (HP:0100777)1.63781208
155Radial bowing (HP:0002986)1.62835074
156Emphysema (HP:0002097)1.62483560
157Leukocytosis (HP:0001974)1.62445667
158Hypoalphalipoproteinemia (HP:0003233)1.62420575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.49648436
2IRAK33.60741131
3PKN22.97387391
4LATS12.84699719
5ERN12.75492756
6KSR22.73059165
7TAOK32.64701684
8GRK72.61652610
9TAOK22.55793068
10MOS2.50124284
11LATS22.27247694
12ACVR1B2.26416768
13STK242.08814020
14CAMK1D1.92785864
15TBK11.86716278
16MAP3K131.86437441
17RIPK11.80734570
18MAP3K91.80546992
19IRAK41.78368656
20ADRBK21.75772017
21EIF2AK31.69109361
22TYK21.67423087
23SIK31.65776749
24MAP3K61.62212136
25RIPK41.60990689
26BMX1.59903825
27ABL21.59512813
28TTN1.51688417
29PDGFRA1.47947113
30LRRK21.47745646
31JAK11.40834642
32TAOK11.40659360
33MST41.37732029
34NEK91.36682358
35RET1.35578512
36JAK31.34936899
37STK31.34666209
38SCYL21.34253892
39BMPR1B1.33132330
40MYLK1.25945694
41BMPR21.25072683
42STK101.23894552
43JAK21.21675224
44PLK21.21146967
45KSR11.19308925
46EEF2K1.19245762
47PTK61.18084093
48MAP3K11.16960407
49EPHB11.16850773
50TXK1.16078458
51MAP3K21.15666126
52CDC42BPA1.15183569
53TGFBR11.13984751
54CAMK1G1.12817241
55PAK61.10355452
56CDK91.09520898
57PTK21.09225250
58DDR21.08866436
59KIT1.08339731
60MAP4K11.07947876
61MAP2K31.07794851
62PRKD21.07593355
63AKT31.07516949
64PRKD31.04414660
65SIK11.03993195
66CDK61.03981422
67MAP2K61.01055118
68MST1R0.99943217
69MAP3K120.98965547
70IRAK20.98921804
71ERBB40.98881134
72RPS6KA40.98232021
73MATK0.97364634
74PIM20.96610078
75TGFBR20.93377075
76MAP3K140.92246009
77PRPF4B0.88042518
78IRAK10.88029059
79PDGFRB0.87369790
80EPHB20.86713689
81ZAP700.86457989
82FGFR40.84229560
83FGFR30.83526867
84MELK0.81666925
85MAP3K30.80652390
86DMPK0.78624763
87MAP3K100.77929295
88CAMKK10.77583212
89BLK0.76165359
90ARAF0.75107746
91CSK0.74118464
92IKBKB0.73928378
93HCK0.73480894
94MAP3K50.72895129
95MAP3K110.71486863
96ABL10.69468687
97BRAF0.68286532
98TRPM70.67449675
99PDPK10.65951972
100IKBKE0.64001574
101PRKCH0.63835795
102STK390.63748593
103NTRK10.63305760
104MAP2K10.63241237
105EPHA30.63205855
106RAF10.60263942
107CHUK0.58585972
108CAMKK20.58511620
109MAP3K80.57252240
110TYRO30.56851427
111STK380.56644312
112FRK0.56247042
113ALK0.55937632
114HIPK20.55898291
115PKN10.55314571
116PDK10.54270079
117GSK3A0.54078277
118MAP2K40.53626908
119LIMK10.52064316
120PAK30.52063620
121PAK20.51729455
122WNK10.51627800
123FGR0.51285009
124FER0.51113746
125NME20.50006220
126PTK2B0.49638096
127MET0.47890426
128EGFR0.47149772
129ROCK10.46773531
130GRK10.46589491
131EIF2AK10.46543149
132ADRBK10.44326866
133FLT30.43805787
134CSF1R0.43288404
135MAPK70.43146322
136STK38L0.42482859
137CLK10.42461139
138MARK30.41542626
139LYN0.41102403
140SGK30.40387992
141ERBB30.40252605
142PRKD10.39334604
143MTOR0.39138039
144PIM10.37999766
145PRKAA20.37112815
146SYK0.36712542
147CDK120.36609974

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041422.58175218
2Staphylococcus aureus infection_Homo sapiens_hsa051502.34524057
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.31924729
4Nitrogen metabolism_Homo sapiens_hsa009102.21611797
5Leishmaniasis_Homo sapiens_hsa051402.18847761
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06421598
7Osteoclast differentiation_Homo sapiens_hsa043801.90491087
8Allograft rejection_Homo sapiens_hsa053301.71092344
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70594691
10Tuberculosis_Homo sapiens_hsa051521.64391348
11Sphingolipid metabolism_Homo sapiens_hsa006001.60825241
12African trypanosomiasis_Homo sapiens_hsa051431.60381827
13SNARE interactions in vesicular transport_Homo sapiens_hsa041301.54997322
14Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49138550
15Malaria_Homo sapiens_hsa051441.47669244
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46944514
17Pancreatic cancer_Homo sapiens_hsa052121.44598603
18Chronic myeloid leukemia_Homo sapiens_hsa052201.40512890
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40181620
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38692398
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38396045
22Adipocytokine signaling pathway_Homo sapiens_hsa049201.37274901
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.36762425
24Toxoplasmosis_Homo sapiens_hsa051451.35955423
25Pertussis_Homo sapiens_hsa051331.35919586
26Other glycan degradation_Homo sapiens_hsa005111.32736398
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31659122
28Amoebiasis_Homo sapiens_hsa051461.30083344
29TNF signaling pathway_Homo sapiens_hsa046681.29550981
30Asthma_Homo sapiens_hsa053101.29327905
31Autoimmune thyroid disease_Homo sapiens_hsa053201.27844318
32Hematopoietic cell lineage_Homo sapiens_hsa046401.25880582
33Shigellosis_Homo sapiens_hsa051311.25664576
34B cell receptor signaling pathway_Homo sapiens_hsa046621.25513726
35Phagosome_Homo sapiens_hsa041451.25436392
36Complement and coagulation cascades_Homo sapiens_hsa046101.22914454
37Caffeine metabolism_Homo sapiens_hsa002321.22331261
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22300983
39PPAR signaling pathway_Homo sapiens_hsa033201.21860682
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19413691
41Salmonella infection_Homo sapiens_hsa051321.17447009
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16231548
43Prolactin signaling pathway_Homo sapiens_hsa049171.14167580
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13307290
45Insulin resistance_Homo sapiens_hsa049311.12116495
46VEGF signaling pathway_Homo sapiens_hsa043701.10846674
47Dorso-ventral axis formation_Homo sapiens_hsa043201.09649892
48Renal cell carcinoma_Homo sapiens_hsa052111.08935146
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08658374
50Legionellosis_Homo sapiens_hsa051341.06500974
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06147436
52Proteoglycans in cancer_Homo sapiens_hsa052051.05133139
53Vibrio cholerae infection_Homo sapiens_hsa051101.03558691
54Rheumatoid arthritis_Homo sapiens_hsa053231.03040688
55Focal adhesion_Homo sapiens_hsa045101.02716059
56Apoptosis_Homo sapiens_hsa042101.00224177
57Arginine biosynthesis_Homo sapiens_hsa002200.97972137
58Influenza A_Homo sapiens_hsa051640.96859782
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95683515
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.95411061
61Bladder cancer_Homo sapiens_hsa052190.94221663
62Herpes simplex infection_Homo sapiens_hsa051680.94122011
63* mTOR signaling pathway_Homo sapiens_hsa041500.94046598
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.92824876
65Chemokine signaling pathway_Homo sapiens_hsa040620.91635807
66Glioma_Homo sapiens_hsa052140.91165627
67Platelet activation_Homo sapiens_hsa046110.89638739
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85765408
69Hepatitis B_Homo sapiens_hsa051610.85496795
70Small cell lung cancer_Homo sapiens_hsa052220.85203313
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.84830316
72Mineral absorption_Homo sapiens_hsa049780.84024075
73Prion diseases_Homo sapiens_hsa050200.83933731
74Sulfur metabolism_Homo sapiens_hsa009200.79851950
75ECM-receptor interaction_Homo sapiens_hsa045120.78918435
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78088822
77Acute myeloid leukemia_Homo sapiens_hsa052210.75676969
78Measles_Homo sapiens_hsa051620.75596856
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74815785
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.74331180
81Type II diabetes mellitus_Homo sapiens_hsa049300.73724327
82Ovarian steroidogenesis_Homo sapiens_hsa049130.73678272
83Hepatitis C_Homo sapiens_hsa051600.72571765
84Endocytosis_Homo sapiens_hsa041440.71496443
85Antigen processing and presentation_Homo sapiens_hsa046120.70550856
86T cell receptor signaling pathway_Homo sapiens_hsa046600.69119095
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.69043285
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68965399
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68753698
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68731355
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68350552
92Non-small cell lung cancer_Homo sapiens_hsa052230.66698932
93MicroRNAs in cancer_Homo sapiens_hsa052060.65502572
94Adherens junction_Homo sapiens_hsa045200.65470286
95Insulin signaling pathway_Homo sapiens_hsa049100.63314481
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62615642
97HIF-1 signaling pathway_Homo sapiens_hsa040660.61415605
98Fatty acid degradation_Homo sapiens_hsa000710.59877977
99Regulation of autophagy_Homo sapiens_hsa041400.58304367
100FoxO signaling pathway_Homo sapiens_hsa040680.57648891
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57589925
102AMPK signaling pathway_Homo sapiens_hsa041520.57459317
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.56613847
104Prostate cancer_Homo sapiens_hsa052150.56429864
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55784420
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54667795
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.54543846
108Type I diabetes mellitus_Homo sapiens_hsa049400.53704923
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53453230
110Graft-versus-host disease_Homo sapiens_hsa053320.53111430
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.52076666
112MAPK signaling pathway_Homo sapiens_hsa040100.51907863
113Viral myocarditis_Homo sapiens_hsa054160.51852949
114GnRH signaling pathway_Homo sapiens_hsa049120.51690980
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50604384
116Bile secretion_Homo sapiens_hsa049760.49821401
117Estrogen signaling pathway_Homo sapiens_hsa049150.49221554
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47796459
119Fatty acid biosynthesis_Homo sapiens_hsa000610.46547066
120TGF-beta signaling pathway_Homo sapiens_hsa043500.46201231
121Protein export_Homo sapiens_hsa030600.42680977
122Glycerolipid metabolism_Homo sapiens_hsa005610.42336776
123Endometrial cancer_Homo sapiens_hsa052130.42282037
124Collecting duct acid secretion_Homo sapiens_hsa049660.40991512
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37071615
126p53 signaling pathway_Homo sapiens_hsa041150.36828220
127Ras signaling pathway_Homo sapiens_hsa040140.34832571
128Melanoma_Homo sapiens_hsa052180.33583247
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32071815

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